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https://www.readbyqxmd.com/read/27216204/a-preliminary-study-of-the-neuroanatomical-correlates-of-primary-writing-tremor-role-of-cerebellum
#1
Ketan Jhunjhunwala, Lija George, Raviteja Kotikalapudi, Pradeep Kumar Gupta, Abhishek Lenka, Albert Stezin, Rajini M Naduthota, Ravi Yadav, Arun Kumar Gupta, Jitender Saini, Pramod Kumar Pal
INTRODUCTION: To explore the neuroanatomical correlates of primary writing tremor (PWT) and the role of cerebellum, using advanced structural neuroimaging. Till date, there are no studies exploring the gray and white matter changes using voxel-based morphometry (VBM) and diffusion tensor imaging (DTI) in PWT. METHODS: Ten male patients with PWT were evaluated clinically and with magnetic resonance imaging. VBM and DTI images of patients were compared with that of 10 healthy male subjects...
August 2016: Neuroradiology
https://www.readbyqxmd.com/read/26871779/putaminal-diffusivity-correlates-with-disease-progression-in-parkinson-s-disease-prospective-6-year-study
#2
Ling-Ling Chan, Kia-Min Ng, Chooi-Sum Yeoh, H Rumpel, Hui-Hua Li, Eng-King Tan
Diffusion tensor imaging (DTI) is an increasingly used noninvasive imaging tool. However its long-term clinical utility is unclear. Parkinson's disease (PD) is a common neurodegenerative disease.We prospectively examined a cohort of 46 Parkinson's disease (PD) patients who underwent diffusion tensor imaging (DTI) of the brain at baseline and 6 years later on a 1.5 Tesla scanner using a standardized protocol. DTI parameters of mean diffusivity (MD) and fractional anisotrophy (FA) were extracted using regions-of-interest (ROIs) analysis from various brain regions...
February 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26834624/effects-of-long-term-mindfulness-meditation-on-brain-s-white-matter-microstructure-and-its-aging
#3
Davide Laneri, Verena Schuster, Bruno Dietsche, Andreas Jansen, Ulrich Ott, Jens Sommer
Although research on the effects of mindfulness meditation (MM) is increasing, still very little has been done to address its influence on the white matter (WM) of the brain. We hypothesized that the practice of MM might affect the WM microstructure adjacent to five brain regions of interest associated with mindfulness. Diffusion tensor imaging was employed on samples of meditators and non-meditators (n = 64) in order to investigate the effects of MM on group difference and aging. Tract-Based Spatial Statistics was used to estimate the fractional anisotrophy of the WM connected to the thalamus, insula, amygdala, hippocampus, and anterior cingulate cortex...
2015: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/26596730/effectiveness-of-riluzole-as-a-pharmacotherapeutic-treatment-option-for-early-cervical-myelopathy-a-double-blinded-placebo-controlled-randomised-controlled-trial
#4
S Rajasekaran, Siddharth N Aiyer, Ajoy Prasad Shetty, Rishi Mugesh Kanna, Anupama Maheswaran, Janardhan Yerram Shetty
PURPOSE: To evaluate the effectiveness of Riluzole as a pharmacotherapeutic treatment option for early cervical myelopathy using clinical parameters and DTI analysis. METHODS: Early cervical myelopathy cases with MJOA scores ≥13, were recruited for the double-blinded, placebo-controlled randomised control trial. Thirty cases with fifteen cases each in the test and placebo group were studied. Analysis was done using diffusion tensor imaging (DTI) and clinical evaluation, pre- and post-institution of sodium channel blocker Riluzole for a period of 1 month (50 mg twice daily)...
June 2016: European Spine Journal
https://www.readbyqxmd.com/read/26582428/retinal-involvement-in-amyotrophic-lateral-sclerosis-a-study-with-optical-coherence-tomography-and-diffusion-tensor-imaging
#5
Annemarie Hübers, Hans Peter Müller, Jens Dreyhaupt, Kathrin Böhm, Florian Lauda, Hayrettin Tumani, Jan Kassubek, Albert C Ludolph, Elmar H Pinkhardt
Although motor neuron degeneration is the predominant feature in ALS, recent data point to a more widespread pathology also comprising non-motor symptoms. Retinal thinning has been reported in a variety of neurodegenerative conditions. Yet, studies of retinal involvement in ALS are sparse and results are heterogeneous. We studied retinal alterations in ALS using a systematic approach combining Optical Coherence Tomography (OCT), Diffusion Tensor Imaging (DTI) and clinical phenotyping. We hypothesized that selective changes of specific retinal layers may be a reflection of overall neurodegeneration as measured by DTI...
March 2016: Journal of Neural Transmission
https://www.readbyqxmd.com/read/26522275/increased-fractional-anisotropy-in-cerebellum-in-obsessive-compulsive-disorder
#6
Tue Hartmann, Sanne Vandborg, Raben Rosenberg, Leif Sørensen, Poul Videbech
BACKGROUND: Previous morphology and diffusion-imaging studies have suggested that structural changes in white matter is an important part of the pathophysiology of obsessive-compulsive disorder (OCD). However, different methodological approaches and the heterogeneity of patient samples question the validity of the findings. Materials and methods In total, 30 patients were matched for age and sex with 30 healthy controls. All participants underwent T1-weighted magnetic resonance imaging, diffusion tensor imaging and T2 fluid-attenuated inversion recovery...
June 2016: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/25731624/disrupted-functional-connectivity-related-to-differential-degeneration-of-the-cingulum-bundle-in-mild-cognitive-impairment-patients
#7
Ying Liang, Yaojing Chen, He Li, Tengda Zhao, Xuan Sun, Ni Shu, Dantao Peng, Zhanjun Zhang
Previous studies have demonstrated that Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI) exhibited anatomical and functional abnormalities in the anterior cingulate cortex (ACC) and accumulating evidence supported the hypothesis that changes in the ACC predict the progression from aMCI to AD. In this study, we aimed to explore how the two functional and structural heterogeneous sub-regions of ACC, namely the dorsal ACC (dACC) and the ventral ACC (vACC), changed in aMCI and whether the structural connectivity affects the functional connectivity between the two ACC subregions...
2015: Current Alzheimer Research
https://www.readbyqxmd.com/read/25320796/automatic-method-for-thalamus-parcellation-using-multi-modal-feature-classification
#8
Joshua V Stough, Jeffrey Glaister, Chuyang Ye, Sarah H Ying, Jerry L Prince, Aaron Carass
Segmentation and parcellation of the thalamus is an important step in providing volumetric assessment of the impact of disease n brain structures. Conventionally, segmentation is carried out on T1-weighted magnetic resonance (MR) images and nuclear parcellation using diffusion weighted MR images. We present the first fully automatic method that incorporates both tissue contrasts and several derived fea-fractional anisotrophy, fiber orientation from the 5D Knutsson representation of the principal eigenvectors, and connectivity between the thalamus and the cortical lobes, as features...
2014: Medical Image Computing and Computer-assisted Intervention: MICCAI ..
https://www.readbyqxmd.com/read/25219775/microcomputed-tomographic-analysis-of-human-condyles-in-unilateral-condylar-hyperplasia-increased-cortical-porosity-and-trabecular-bone-volume-fraction-with-reduced-mineralisation
#9
L H E Karssemakers, J W Nolte, D B Tuinzing, G E J Langenbach, P G Raijmakers, A G Becking
Unilateral condylar hyperplasia or hyperactivity is a disorder of growth that affects the mandible, and our aim was to visualise the 3-dimensional bony microstructure of resected mandibular condyles of affected patients. We prospectively studied 17 patients with a clinical presentation of progressive mandibular asymmetry and an abnormal single-photon emission computed tomographic (SPECT) scan. All patients were treated by condylectomy to arrest progression. The resected condyles were scanned with micro-CT (18 μm resolution)...
December 2014: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/24903632/characteristics-of-injury-of-the-corticospinal-tract-and-corticoreticular-pathway-in-hemiparetic-patients-with-putaminal-hemorrhage
#10
Jin Sun Yoo, Byung Yeon Choi, Chul Hoon Chang, Young Jin Jung, Seong Ho Kim, Sung Ho Jang
BACKGROUND: No study on the characteristics of injury of the corticospinal tract (CST) or corticoreticular pathway (CRP) in patients with putaminal hemorrhage has been reported. In this study, using diffusion tensor tractography, we attempted to investigate the characteristics of injury of the CST and CRP in hemiparetic patients with putaminal hemorrhage. METHOD: Fifty seven consecutive patients with putaminal hemorrhage and 57 healthy control subjects were recruited for this study...
2014: BMC Neurology
https://www.readbyqxmd.com/read/24059625/secondary-corpus-callosum-abnormalities-associated-with-antiepileptic-drugs-in-temporal-lobe-epilepsy-a-diffusion-tensor-imaging-study
#11
H P Günbey, K Ercan, A S Fındıkoğlu, E Bilir, M Karaoglanoglu, F Komurcu, A Alhan
Epilepsy is more than a grey-matter disorder affecting large white matter connections of the brain with seizure generation and propagation. The mechanism for such changes remains unclear. The purpose of this study was to investigate the microstructural changes in the corpus callosum in temporal lobe epilepsy (TLE) patients and whether these abnormalities are related to antiepileptic drug (AED) therapy. Ten TLE patients receiving AED therapy, ten TLE patients with no therapy and ten controls were included in the study...
May 15, 2011: Neuroradiology Journal
https://www.readbyqxmd.com/read/24002417/analysis-of-high-voltage-electrical-spinal-cord-injury-using-diffusion-tensor-imaging
#12
Suk Hoon Ohn, Deog Young Kim, Ji Cheol Shin, Seung Min Kim, Woo-Kyoung Yoo, Seung-Koo Lee, Chang-Hyun Park, Kwang-Ik Jung, Ki Un Jang, Cheong Hoon Seo, Sung Hye Koh, Bora Jung
The aim of this study was to investigate spinal cord injury (SCI) on the basis of diffusion tensor imaging (DTI) in patients with high-voltage electrical injury. We recruited eight high-voltage electrical injury patients and eight healthy subjects matched for age and sex. DTI and central motor conduction time were acquired in both the patient and control groups. We obtained DTI indices according to the spinal cord levels (from C2 to C7) and cross-section locations (anterior, lateral, and posterior). Fractional anisotrophy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were compared between the two groups; additionally, they were compared in relation to spinal cord level and cross-section location...
November 2013: Journal of Neurology
https://www.readbyqxmd.com/read/23553830/diffusion-tensor-imaging-of-extraocular-muscle-using-two-dimensional-single-shot-interleaved-multiple-inner-volume-imaging-diffusion-weighted-epi-at-3-tesla
#13
COMPARATIVE STUDY
Hyung Suk Seo, Seong-Eun Kim, John Rose, J Rock Hadley, Dennis L Parker, Eun-Kee Jeong
PURPOSE: To evaluate the feasibility of diffusion tensor imaging (DTI) for the medial and lateral rectus extraocular muscle (EOM) evaluation, to investigate the normal DTI parameters of the medial and lateral rectus EOM, and to compare with other skeletal muscle. MATERIALS AND METHODS: Seven multiple sclerosis patients and five normal subjects (M:F = 5:7, mean age = 31.6 ± 9.2) without EOM disorder were included. The orbital DTIs using 2D-ss-IMVI-DWEPI were scanned with b = 500 s/mm(2) and 12 directions...
November 2013: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/23245938/efficacy-of-diffusion-tensor-anisotropy-indices-and-tractography-in-assessing-the-extent-of-severity-of-spinal-cord-injury-an-in%C3%A2-vitro-analytical-study-in-calf-spinal-cords
#14
Shanmughanathan Rajasekaran, Rishi M Kanna, Ajoy P Shetty, Venkatachalam Ilayaraja
BACKGROUND CONTEXT: Signal intensity changes observed in magnetic resonance imaging (MRI) do not reveal the actual severity of axonal damage incurred in spinal cord injuries. Diffusion tensor imaging (DTI) is an imaging technique with a potential to track individual nerve fiber tracts. PURPOSE: We explored the use of DTI in quantifying the extent of spinal cord injury and differentiated areas of injured spinal cord from regions with intact fiber tracts in a cadaveric animal model...
December 2012: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/23160647/effect-of-antenatal-growth-on-brain-white-matter-maturation-in-preterm-infants-at-term-using-tract-based-spatial-statistics
#15
Virva Lepomäki, Jaakko Matomäki, Helena Lapinleimu, Liisa Lehtonen, Leena Haataja, Markku Komu, Riitta Parkkola
BACKGROUND: White matter maturation of infants can be studied using diffusion tensor imaging (DTI). DTI of the white matter of the infant brain provides the best available clinical measures of brain tissue organisation and integrity. OBJECTIVE: The purpose of this study was to compare white matter maturation between preterm infants born small for gestational age (SGA) and preterms with weight appropriate for gestational age (AGA) at birth. MATERIALS AND METHODS: A total of 36 preterm infants were enrolled in the study (SGA, n = 9)...
January 2013: Pediatric Radiology
https://www.readbyqxmd.com/read/23070746/dti-tractography-and-white-matter-fiber-tract-characteristics-in-euthymic-bipolar-i-patients-and-healthy-control-subjects
#16
Carinna M Torgerson, Andrei Irimia, Alex D Leow, George Bartzokis, Teena D Moody, Robin G Jennings, Jeffry R Alger, John Darrell Van Horn, Lori L Altshuler
With the introduction of diffusion tensor imaging (DTI), structural differences in white matter (WM) architecture between psychiatric populations and healthy controls can be systematically observed and measured. In particular, DTI-tractography can be used to assess WM characteristics over the entire extent of WM tracts and aggregated fiber bundles. Using 64-direction DTI scanning in 27 participants with bipolar disorder (BD) and 26 age-and-gender-matched healthy control subjects, we compared relative length, density, and fractional anisotrophy (FA) of WM tracts involved in emotion regulation or theorized to be important neural components in BD neuropathology...
June 2013: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/22825739/relationship-between-apolipoprotein-e4-genotype-and-white-matter-integrity-in-hiv-positive-young-adults-in-south-africa
#17
Jacqueline Hoare, Jenny Westgarth-Taylor, Jean-Paul Fouche, Marc Combrinck, Bruce Spottiswoode, Dan J Stein, John A Joska
HIV-associated dementia (HAD) is a serious neuropsychiatric disorder affecting people with AIDS. Host genotype may affect the pathogenesis of HIV in the central nervous system (CNS). One gene relevant to the individual variation in acquiring HAD may be Apolipoprotein E (ApoE). We aimed to investigate the relationship of ApoE genotype to neuropsychological function and white matter integrity of the corpus callosum in a region of interest a priori analysis of HIV-positive subjects with clade C HIV. Forty-five subjects underwent ApoE genotyping, neuropsychological testing, and diffusion tensor imaging (DTI)...
April 2013: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/22569999/a-diffusion-tensor-imaging-and-neuropsychological-study-of-prospective-memory-impairment-in-south-african-hiv-positive-individuals
#18
RANDOMIZED CONTROLLED TRIAL
Hoare Jacqueline, Westgarth-Taylor Jenny, Fouche Jean-Paul, Spottiswoode Bruce, Paul Robert, Thomas Kevin, Stein Dan, Joska John
HIV-associated prospective memory (ProM) impairment has emerged, in earlier studies as a significant predictor of medication management and independence in activities of daily living. The relationship between ProM and white matter integrity in HIV has not previously been investigated. Participants, including 128 HIV-infected individuals and 32 healthy controls, were assessed using a comprehensive neuropsychological evaluation and both objective and subjective measures of ProM. Diffusion tensor imaging (DTI) was utilized to investigate the relationship of white matter integrity to ProM in a randomly selected subsample of 40 HIV positive subjects, using a whole brain voxel-based approach to define fractional anisotrophy (FA) and mean diffusion (MD)...
September 2012: Metabolic Brain Disease
https://www.readbyqxmd.com/read/22418396/diffusion-tensor-imaging-tractography-of-the-fornix-and-belief-confidence-in-first-episode-psychosis
#19
Lisa Buchy, David Luck, Yvonne Czechowska, Ashok Malla, Ridha Joober, Martin Lepage
Previous studies have demonstrated that patients with psychosis are more confident in beliefs and judgments compared to healthy participants and psychiatric controls with major depression. A recent study conducted by our research group has provided evidence for hippocampal pathology in association with overconfidence in a first-episode psychosis sample. The fornix is the primary efferent neural pathway of the hippocampus and may also play a role in self-certainty pathophysiology. The current investigation applied diffusion tensor imaging tractography to a first-episode psychosis sample to explore whether integrity of the fornix is associated with self-certainty...
May 2012: Schizophrenia Research
https://www.readbyqxmd.com/read/22331645/cortical-plasticity-is-preserved-in-nondemented-older-individuals-with-severe-ischemic-small-vessel-disease
#20
Jonathan List, Thomas Duning, Julia Kürten, Michael Deppe, Eike Wilbers, Agnes Flöel
Ischemic small vessel disease (SVD) is a common finding on routine scans in older people, but cognitive sequelae vary considerably. To improve understanding of mechanisms underlying decline or preservation of cognitive function in this condition, we assessed cognition and cortical plasticity in 20 elderly subjects with severe SVD and 20 age-matched controls without SVD, as rated on conventional MRI. Cognitive status was determined with a neuropsychological test battery, cortical plasticity induced with a paired associative stimulation protocol...
June 2013: Human Brain Mapping
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