Jakob Wasserthal, Klaus H Maier-Hein, Peter F Neher, Robert C Wolf, Georg Northoff, John L Waddington, Katharina M Kubera, Stefan Fritze, Anais Harneit, Lena S Geiger, Heike Tost, Dusan Hirjak
The specific role of white matter (WM) microstructure in parkinsonism among patients with schizophrenia spectrum disorders (SSD) is largely unknown. To determine whether topographical alterations of WM microstructure contribute to parkinsonism in SSD patients, we examined healthy controls (HC, n=16) and SSD patients with and without parkinsonism, as defined by Simpson-Angus Scale total score of ≥4 (SSD-P, n=33) or <4 (SSD-nonP, n=62). We used whole brain tract-based spatial statistics (TBSS), tractometry (along tract statistics using TractSeg) and graph analytics (clustering coefficient (CCO), local betweenness centrality (BC)) to provide a framework of specific WM microstructural changes underlying parkinsonism in SSD...
September 2021: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology