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https://www.readbyqxmd.com/read/28323757/the-performance-of-human-papillomavirus-biomarkers-in-predicting-anal-high-grade-squamous-intraepithelial-lesions-in-gay-and-bisexual-men
#1
Fengyi Jin, Jennifer M Roberts, Andrew E Grulich, I Mary Poynten, Dorothy A Machalek, Alyssa Cornall, Samuel Phillips, Deborah Ekman, Ross L Mcdonald, Richard J Hillman, David J Templeton, Annabelle Farnsworth, Suzanne M Garland, Christopher K Fairley, Sepehr N Tabrizi
BACKGROUND: We evaluate the performance of human papillomavirus (HPV) biomarkers in prediction of anal histological high-grade squamous intraepithelial lesions (HSIL) in gay and bisexual men (GBM) in Sydney, Australia. DESIGN: Baseline analysis of a three-year cohort study METHODS:: The Study of the Prevention of Anal Cancer (SPANC) is natural history study of anal HPV infection in GBM aged ≥35 years. All participants completed cytological and histological assessments...
March 18, 2017: AIDS
https://www.readbyqxmd.com/read/28319573/vascular-smooth-muscle-cell-maturation-stage-and-ki-67-index-are-diagnostic-biomarkers-for-pathologic-grade-of-ovarian-teratoma
#2
Masako Hongo-Kohama, Atsushi Kurata, Hirotsugu Hashimoto, Koji Fujita, Hajime Horiuchi, Toshitaka Nagao, Masahiko Kuroda
Although immature teratoma of the ovary is a rare disease, its pathologic grading, especially between low-grade (grade 1) and high-grade (grade 2 or 3) immature teratomas, is important for optimal therapy and prognosis. This grading, however, is currently solely dependent on quantitation of neuroepithelial components as judged by subjective assessments. As we have recently successfully studied the maturation of vascular smooth muscle cells (SMCs) in other organs using an h-caldesmon to α-smooth muscle actin (α-SMA) ratio, we decided to use this ratio to investigate a potential link between teratoma grade and SMC maturation, in combination with Ki-67 index...
March 17, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28319069/the-branched-chain-amino-acid-transaminase-1-sustains-growth-of-antiestrogen-resistant-and-er%C3%AE-negative-breast-cancer
#3
V Thewes, R Simon, M Hlevnjak, M Schlotter, P Schroeter, K Schmidt, Y Wu, T Anzeneder, W Wang, P Windisch, M Kirchgäßner, N Melling, N Kneisel, R Büttner, U Deuschle, H P Sinn, A Schneeweiss, S Heck, S Kaulfuss, H Hess-Stumpp, J G Okun, G Sauter, A E Lykkesfeldt, M Zapatka, B Radlwimmer, P Lichter, M Tönjes
Antiestrogen-resistant and triple-negative breast tumors pose a serious clinical challenge because of limited treatment options. We assessed global gene expression changes in antiestrogen-sensitive compared with antiestrogen-resistant (two tamoxifen resistant and two fulvestrant resistant) MCF-7 breast cancer cell lines. The branched-chain amino acid transaminase 1 (BCAT1), which catalyzes the first step in the breakdown of branched-chain amino acids, was among the most upregulated transcripts in antiestrogen-resistant cells...
March 20, 2017: Oncogene
https://www.readbyqxmd.com/read/28316325/silencing-of-the-small-gtpase-diras3-induces-cellular-senescence-in-human-white-adipose-stromal-progenitor-cells
#4
Asim Ejaz, Monika Mattesich, Werner Zwerschke
Inhibition of Akt-mTOR signaling protects from obesity and extends life span in animals. In the present study, we analyse the impact of the small GTPase, GTP-binding RAS-like 3 (DIRAS3), a recently identified weight-loss target gene, on cellular senescence in adipose stromal/progenitor cells (ASCs) derived from human subcutaneous white adipose tissue (sWAT). We demonstrate that DIRAS3 knock-down (KD) in ASCs induces activation of Akt-mTOR signaling and proliferation arrest. DIRAS3 KD ASCs lose the potential to form colonies and are negative for Ki-67...
March 17, 2017: Aging
https://www.readbyqxmd.com/read/28315203/adc-histogram-analysis-of-cervical-cancer-aids-detecting-lymphatic-metastases-a-preliminary-study
#5
Stefan Schob, Hans Jonas Meyer, Nikolaos Pazaitis, Dominik Schramm, Kristina Bremicker, Marc Exner, Anne Kathrin Höhn, Nikita Garnov, Alexey Surov
PURPOSE: Apparent diffusion coefficient (ADC) histogram analysis has been used to some extent in cervical cancer (CC) to distinguish between low-grade and high-grade tumors. Although this differentiation is undoubtedly helpful, it would be even more crucial in the presurgical setting to determine whether a tumor already gained the potential to metastasize via the lymphatic system. So far, no studies investigated the potential of 3T ADC histogram analysis in CC to differentiate between nodal-positive and nodal-negative entities...
March 17, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28304400/evaluation-of-p16-ki-67-dual-stained-cytology-as-triage-test-for-high-risk-human-papillomavirus-positive-women
#6
Renée Mf Ebisch, Judith van der Horst, Meyke Hermsen, L Lucia Rijstenberg, Judith Em Vedder, Johan Bulten, Remko P Bosgraaf, Viola Mj Verhoef, Daniëlle Am Heideman, Peter Jf Snijders, Chris Jlm Meijer, Folkert J van Kemenade, Leon Fag Massuger, Willem Jg Melchers, Ruud Lm Bekkers, Albert G Siebers
The aim of this study was to evaluate the clinical utility of p16/Ki-67 dual staining, for the identification of CIN in high-risk HPV-positive women from a non-responder screening cohort. P16/Ki-67 dual staining, Pap cytology, and HPV16/18 genotyping were performed on physician-taken liquid-based samples from 495 women who tested high-risk HPV positive on self-sampled material (PROHTECT-3B study). Different triage strategies involving p16/Ki-67 dual staining were evaluated for sensitivity, specificity, and predictive value for ≥CIN2 and ≥CIN3, and compared to Pap cytology with a threshold of atypical cells of undetermined significance...
March 17, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28304151/cardiac-cell-proliferation-is-not-necessary-for-exercise-induced-cardiac-growth-but-required-for-its-protection-against-ischaemia-reperfusion-injury
#7
Yihua Bei, Siyi Fu, Xiangming Chen, Mei Chen, Qiulian Zhou, Pujiao Yu, Jianhua Yao, Hongbao Wang, Lin Che, Jiahong Xu, Junjie Xiao
The adult heart retains a limited ability to regenerate in response to injury. Although exercise can reduce cardiac ischaemia/reperfusion (I/R) injury, the relative contribution of cardiac cell proliferation including newly formed cardiomyocytes remains unclear. A 4-week swimming murine model was utilized to induce cardiac physiological growth. Simultaneously, the antineoplastic agent 5-fluorouracil (5-FU), which acts during the S phase of the cell cycle, was given to mice via intraperitoneal injections. Using EdU and Ki-67 immunolabelling, we showed that exercise-induced cardiac cell proliferation was blunted by 5-FU...
March 17, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28302537/mcm2-expression-in-serrated-polyps-demonstrates-aberrant-cellular-proliferation
#8
Danielle Fortuna, Bruce Boman, Raymond O'Neil, Juan Palazzo
In normal colonic epithelium, the proliferative zone is limited to the lower half of the colonic crypt. Evaluating the changes in the colonic epithelial proliferation can be useful in understanding pathophysiology of various diseases. Our aim was to investigate the proliferative compartment of serrated polyps (SPs) using MCM2, a protein involved in DNA replication, and assess for changes along the SP spectrum. Immunohistochemistry was performed on serrated polyps (16 microvesicular-type hyperplastic polyps (HP), 58 sessile serrated adenomas (SSA), seven SSAs with dysplasia) and six sections of normal colon using anti-MCM2 antibody...
March 13, 2017: Human Pathology
https://www.readbyqxmd.com/read/28302457/mucosal-vaccination-with-heterologous-viral-vectored-vaccine-targeting-subdominant-siv-accessory-antigens-strongly-inhibits-early-viral-replication
#9
Huanbin Xu, Anne-Marie Andersson, Emeline Ragonnaud, Ditte Boilesen, Anders Tolver, Benjamin Anderschou Holbech Jensen, James L Blanchard, Alfredo Nicosia, Antonella Folgori, Stefano Colloca, Riccardo Cortese, Allan Randrup Thomsen, Jan Pravsgaard Christensen, Ronald S Veazey, Peter Johannes Holst
Conventional HIV T cell vaccine strategies have not been successful in containing acute peak viremia, nor in providing long-term control. We immunized rhesus macaques intramuscularly and rectally using a heterologous adenovirus vectored SIV vaccine regimen encoding normally weakly immunogenic tat, vif, rev and vpr antigens fused to the MHC class II associated invariant chain. Immunizations induced broad T cell responses in all vaccinees. Following up to 10 repeated low-dose intrarectal challenges, vaccinees suppressed early viral replication (P=0...
March 8, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28300722/effect-of-5-aminolevulinic-acid-photodynamic-therapy-on-keratinocyte-proliferation-and-apoptosis-in-condyloma-acuminatum
#10
Guangwen Yin, Ke Sha, Bingjie Cai, Fangfang Li, Xuyang Li, Xianxian Xia, Xinxin Pan
BACKGROUND: The effect of 5-aminolevulinic acid photodynamic therapy on keratinocyte proliferation and apoptosis in condyloma acuminatum tissues was evaluated. METHODS: An immunohistochemical method and TdT-mediated dUTP nick end labeling were performed to detect the positive expression of the keratinocyte proliferation-related gene Ki-67 and apoptosis, respectively, in condyloma acuminatum tissues. RESULTS: Of 52 cases, 44 showed positive expression of Ki-67 in condyloma acuminatum keratinocytes before the treatment, with a positive expression rate of 84...
March 11, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28300573/concomitant-expression-of-ezrin-and-her2-predicts-distant-metastasis-and-poor-prognosis-of-patients-with-salivary-gland-carcinomas
#11
Kazuki Hashimoto, Ryuichi Hayashi, Takashi Mukaigawa, Manabu Yamazaki, Satoshi Fujii
Salivary gland carcinomas (SGCs) exhibit heterogeneous biological behaviors, including the formation of distant metastases, which is a critical event associated with poor prognosis. Ezrin, which is a member of the ezrin-radixin-moesin family of plasma membrane-cytoskeleton linker proteins, may provide a marker for metastasis and poor survival of patients with cancer. The aim of the present study was to investigate the relationship between ezrin expression and the expression of HER2, p53, and Ki-67 as well as clinicopathological factors in SGCs...
March 11, 2017: Human Pathology
https://www.readbyqxmd.com/read/28299888/the-relationship-of-race-oncotype-dx-and-ki67-in-a-population-highly-screened-for-breast-cancer
#12
Amber A Guth, Jennifer Chun Kim, Shira Schwartz, Jennifer Montes, Rebecca Akiko Snyder, Deborah Axelrod, Freya Schnabel
Oncotype DX recurrence score (ODX) can predict risk of invasive breast cancer recurrence and benefit of chemotherapy. Literature is limited on the relationship of ODX and race in women with hormone receptor positive and node negative/positive disease. Our study examines the relationship between race and clinical characteristics within a population of highly screened women with newly diagnosed breast cancer. The institutional Breast Cancer Database was queried for patients with newly diagnosed breast cancer between January2010 and March2015...
March 2017: Breast Journal
https://www.readbyqxmd.com/read/28299580/the-expression-of-hdac7-in-cancerous-gastric-tissues-is-positively-associated-with-distant-metastasis-and-poor-patient-prognosis
#13
Y Yu, F Cao, X Yu, P Zhou, Q Di, J Lei, Y Tai, H Wu, X Li, X Wang, W Zhang, P Li, Y Li
PURPOSE: To characterize the expression patterns of HDAC7 in patients with gastric cancer and evaluate the prognostic value of HDAC7 in gastric cancer. METHODS: The expression of histone deacetylase 7 (HDAC7) was detected in paraffin-embedded gastric cancer samples from 86 patients by immunohistochemistry, and the differences in the expression of HDAC7 between cancerous and corresponding adjacent noncancerous tissues were compared using the Wilcoxon matched-pairs signed rank test...
March 15, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28298390/clinical-usefulness-of-the-free-web-based-image-analysis-application-immunoratio-for-assessment-of-ki-67-labelling-index-in-breast-cancer
#14
Min-Kyung Yeo, Hee Eun Kim, Sung Hun Kim, Byung Joo Chae, Byung Joo Song, Ahwon Lee
AIMS: Ki-67 is a prognostic marker in breast cancer; however, the use of the Ki-67 labelling index (LI) in clinical practice requires a consistent and easily accessible scoring method. The present study evaluated the use of the free internet-based image analysis program ImmunoRatio to score Ki-67 LI in breast cancer in comparison with manual counting. METHODS: Ki-67 immunohistochemical detection was performed in 577 breast cancer cases, and the Ki-67 LI was determined by ImmunoRatio and manual counting...
March 15, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28297760/-promoting-effect-of-cyclin-d1-overexpression-on-proliferation-and-epithelial-mesenchymal-transition-of-cervical-squamous-cell-carcinoma-siha-cells
#15
P Wang, S Liu, B Cheng, X Z Wu, S S Ding, L Xu, Y Liu, L Duan, S Z Sun
Objective: To study effects of cyclin D1 overexpression on the proliferation and differentiation of cervical squamous cell carcinoma SiHa cells and to investigate related signaling molecules. Methods: Primers were designed to amplify the full length of cyclin D1 gene and cyclin D1 gene was amplified by PCR for constructing pcDNA3.1 plasmid vector. The construct was then transfected into SiHa cells, and the cells with stable overexpression of cyclin D1 were established, cyclin D1 gene and protein expression were detected by RT-PCR and Western blot, respectively...
March 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28297754/-clinicopathologic-characteristics-of-head-and-neck-carcinoma-showing-thymus-like-element
#16
X J Cui, C Y Zhang, P Su, B Lyu, Y B Ren, X S Fan, X F Zhang, Y Wang, Y H Song, Z Y Liu
Objective: To investigate clinicopathological features of carcinoma showing thymus-like elements (CASTLE) in the head and neck regions. Methods: Clinicopathological data of 7 patients with CASTLE in the head and neck regions were retrospectively reviewed.Immunohistochemical staining and in situ hybridization for EBER were performed. BRAF(V600E) mutation was examined by ARMS method in 6 cases. Results: There were 5 females and 2 males with age between 49 and 78 years (average of 65.6 years). All tumors were solitary nodular lesions with an infiltrative border, including 6 intrathyroid tumors and 1 extrathyroid tumor in the laryngeal pharynx...
March 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28297421/characteristics-of-quantitative-perfusion-parameters-on-dynamic-contrast-enhanced-mri-in-mammographically-occult-breast-cancer
#17
Jung Kyu Ryu, Sun Jung Rhee, Jeong Yoon Song, Soo Hyun Cho, Geon-Ho Jahng
The purpose of this study was to compare the characteristics of quantitative perfusion parameters obtained from dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) in patients with mammographically occult (MO) breast cancers and those with mammographically visible (MV) breast cancers. Quantitative parameters (AUC, Ktrans,kep,ve,vp, and wi) from 13 MO breast cancers and 16 MV breast cancers were mapped after the DCE-MRI data were acquired. Various prognostic factors, including axillary nodal status, estrogen receptor (ER), progesterone receptor (PR), Ki-67, p53, E-cadherin, and human epidermal growth factor receptor 2 (HER2) were obtained in each group...
September 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28296778/malignant-solitary-fibrous-tumor-in-retroperitoneum-a-case-report-and-literature-review
#18
Yihong Zhou, Xi Chu, Ye Yi, Liang Tong, Yingbo Dai
RATIONALE: Solitary fibrous tumor (SFT) is a rare mesenchymal tumor occurs in various sites. Malignant SFT in retroperitoneum is extremely rare. PATIENT CONCERNS: We report a case of malignant retroperitoneal SFT in a 59-year-old man presented with right flank pain for 1 month. DIAGNOSES, INTERVENTIONS AND OUTCOMES: A laparotomy and resection of the tumor were performed, the histopathologic and immunohistochemical findings were consistent with malignant retroperitoneal SFT...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28295854/diffusion-kurtosis-imaging-for-differentiating-borderline-from-malignant-epithelial-ovarian-tumors-a-correlation-with-ki-67-expression
#19
Hai Ming Li, Shu Hui Zhao, Jin Wei Qiang, Guo Fu Zhang, Feng Feng, Feng Hua Ma, Yong Ai Li, Wei Yong Gu
PURPOSE: To investigate the use of diffusion kurtosis imaging (DKI) in differentiating borderline from malignant epithelial ovarian tumors (MEOTs) and to correlate DKI parameters with Ki-67 expression. MATERIALS AND METHODS: Fifty-two consecutive patients with epithelial ovarian tumors (17 borderline epithelial ovarian tumors, BEOTs; 35 MEOTs) were prospectively evaluated using DKI with b values of 0, 500, 1000, 1500, 2000, and 2500 s/mm(2) and standard diffusion-weighted imaging (DWI) with b values of 0 and 1000 s/mm(2) using a 1...
March 10, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28295252/meta-analysis-of-biomarkers-predicting-risk-of-malignant-progression-in-barrett-s-oesophagus
#20
REVIEW
K Altaf, J-J Xiong, D De la Iglesia, L Hickey, A Kaul
BACKGROUND: Barrett's oesophagus is a precursor to the development of oesophageal adenocarcinoma. This study sought to clarify the role of genetic, chromosomal and proliferation biomarkers that have been the subjects of multiple studies through meta-analysis. METHODS: MEDLINE, Embase, PubMed and the Cochrane Library were searched for clinical studies assessing the value of p53, p16, Ki-67 and DNA content abnormalities in Barrett's oesophagus. The main outcome measure was the risk of development of high-grade dysplasia (HGD) or oesophageal adenocarcinoma...
April 2017: British Journal of Surgery
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