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Effects of drugs on periodontal health

Xuan Li, Wei Luo, Tsz Wing Ng, Ping Chung Leung, Chengfei Zhang, Ken Cham-Fai Leung, Lijian Jin
Severe gum disease (periodontitis), which is one of the major global oral diseases, results from microbe-host dysbiosis and dysregulated immuno-inflammatory responses. It seriously affects oral health and general wellbeing with significant socio-economic implications. It has been well documented that natural flavonoids such as baicalin (BA) and baicalein (BE) possess potent anti-inflammatory effects. However, their intrinsic poor solubility and low bioavailability severely limit their biomedical applications...
June 26, 2017: Nanoscale
C P Ramôa, T Eissenberg, S E Sahingur
Cigarette smoking increases the risk of developing several systemic conditions including cancer, cardiovascular and pulmonary diseases. Cigarette smoking is also detrimental to oral health as it increases the incidence and severity of oral cancer, periodontal diseases and peri-implantitis, as well as impacting negatively on the dental patients' response to therapy. Therefore, consideration of smoking behavior and recommendation of smoking cessation are important parts of dental treatment planning. However, cigarettes are no longer the most popular form of tobacco use among adolescents in the United States and globally...
April 10, 2017: Journal of Periodontal Research
Jiang Yaling, Feng Mingye, Cheng Lei
Dental caries and periodontal diseases are common chronic infectious diseases that cause serious damage to oral health. Bacteria is the primary factor leading to such conditions. As a dental plaque control method, chemotherapeutic agents face serious challenges in dental care because of the specific physiological and anatomical characteristics of the oral cavity. Nanodrug delivery system is a series of new drug delivery systems at nanoscale, and it can target cells, promote sustainedrelease effects, and enhance biodegradation...
February 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
Fabien Cohen
This article reminds you that, whatever the psychoactive substance in question, it is not one that has repercussions on the oral health of its user. This affects both the tooth, the periodontal and oral mucosa. Drug addicts, especially those engaged in polydrug use, represent the population at the largest risk for oral cancer. Of all the factors, smoking is by far the largest risk. The alcohol has a synergistic effect with the tobacco, so that the combined effect is more than multiplied. Preventing risks of these products is possible through good oral hygiene and lifestyle, preventive care and followed by a regular dentist...
December 2016: La Presse Médicale
Zuhair S Natto, Majdi Aladmawy, Heba K Alshaeri, Mohammed Alasqah, Athena Papas
OBJECTIVE: To investigate possible correlations of clinical attachment level and pocket depth with number of medications in elderly individuals. METHODS: Intra-oral examinations for 139 patients visiting Tufts dental clinic were done. Periodontal assessments were performed with a manual UNC-15 periodontal probe to measure probing depth (PD) and clinical attachment level (CAL) at 6 sites. Complete lists of patients' medications were obtained during the examinations...
March 2016: Ghana Medical Journal
Katia L Costa, Zuila A Taboza, Gisele B Angelino, Virginia R Silveira, Renan Montenegro, Alex N Haas, Rodrigo O Rego
BACKGROUND: Little evidence is available regarding the effects of long-term periodontal infection on diabetes mellitus (DM) control. The aim of this retrospective cohort study is to evaluate influence of periodontal status on changes of glycated hemoglobin (HbA1c) levels of patients with type 2 DM (DMt2). METHODS: Eighty patients (mean age: 56.0 ± 8.9 years) with DMt2 were included. Patients were non-smokers, aged ≥40 years, and using antidiabetic drugs. Demographics, health history, and HbA1c levels were retrieved from medical charts...
January 2017: Journal of Periodontology
Shariq Najeeb, Zohaib Khurshid, Sana Zohaib, Muhammad Sohail Zafar
Melatonin (N-acetyl-5-methoxy tryptamine) is a substance secreted by multiple organs in vertebrates. In addition to playing a part in the circadian cycle of the body, melatonin is known to have antioxidant, antiinflammatory, and antioncotic effects on human tissues. Oral cavity is affected by a number of conditions such as periodontitis, mucositis, cancers, and cytotoxicity from various drugs or biomaterials. Research has suggested that melatonin is effective in treating the aforementioned pathologies. Furthermore, melatonin has been observed to enhance osseointegration and bone regeneration...
August 2016: Kaohsiung Journal of Medical Sciences
Harpreet Singh Grover, Shalini Kapoor, Ajita Singh
OBJECTIVES: The impact of simvastatin (SMV), a cholesterol lowering drug, on bone metabolism appears to involve complex interaction with cholesterol metabolites, hormones, inflammatory mediators and growth factors, thus having direct influence on extent and severity of periodontitis. The present study aims to evaluate the in vivo effect of subgingivally delivered SMV gel (1.2 mg) as a local drug-delivery agent on clinical parameters and on interleukin-6 (IL-6), interleukin-8 (IL-8) and interleukin-10 (IL-10) levels in gingival crevicular fluid (GCF) of chronic periodontitis patients...
May 2016: Journal of Oral Biology and Craniofacial Research
Rania Livada, Wes Shelton, Paul S Bland, Jacob Shiloal
AIM: To illustrate the negative effect of calcium channel blocker (CCB) drugs on the gingival tissues and the reversibility of these lesions. CASE DESCRIPTION: The authors examined a forty-eight year-old male patient with drug-induced gingival enlargement associated with diltiazem, a CCB drug. Prior to initiating the proposed periodontal treatment, the patient was advised to consult his physician, for a possible switch to a different anti-hypertensive drug. The patient returned to the clinic three months later with a significant regression of the gingival overgrowth, which was induced by the patient ceasing the prescribed regimen without medical consultation or periodontal intervention...
October 2015: Journal of the Tennessee Dental Association
Bharat Suneja, Saroj Chopra, Abi M Thomas, Jeyraj Pandian
INTRODUCTION: Gingival overgrowth, a well-known side effect of chronic phenytoin therapy has also been known to be caused by other anti epileptic drugs (AED's). Various factors like plaque, gingival inflammation, and periodontal health have been postulated to effect gingival overgrowth. AIM: To identify the AED having an effect on gingival overgrowth and to study the factors affecting it. MATERIALS AND METHODS: Three groups of 30 children each on monotherapy of phenytoin, sodium valproate, and carbamazepine were longitudinally followed for six months...
January 2016: Journal of Clinical and Diagnostic Research: JCDR
Terry C Simpson, Jo C Weldon, Helen V Worthington, Ian Needleman, Sarah H Wild, David R Moles, Brian Stevenson, Susan Furness, Zipporah Iheozor-Ejiofor
BACKGROUND: Glycaemic control is a key issue in the care of people with diabetes mellitus (DM). Periodontal disease is the inflammation and destruction of the underlying supporting tissues of the teeth. Some studies have suggested a bidirectional relationship between glycaemic control and periodontal disease. This review updates the previous version published in 2010. OBJECTIVES: The objective is to investigate the effect of periodontal therapy on glycaemic control in people with diabetes mellitus...
2015: Cochrane Database of Systematic Reviews
Pitchai Balakumar, Muthu Kavitha, Suresh Nanditha
Oral health is an imperative part of overall human health. Oral disorders are often unreported, but are highly troublesome to human health in a long-standing situation. A strong association exists between cardiovascular drugs and oral adverse effects. Indeed, several cardiovascular drugs employed clinically have been reported to cause oral adverse effects such as xerostomia, oral lichen planus, angioedema, aphthae, dysgeusia, gingival enlargement, scalded mouth syndrome, cheilitis, glossitis and so forth. Oral complications might in turn worsen the cardiovascular disease condition as some reports suggest an adverse correlation between periodontal oral disease pathogenesis and cardiovascular disease...
December 2015: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Byalakere Rudraiah Chandra Shekar, Ramesh Nagarajappa, Shankarappa Suma, Rupesh Thakur
BACKGROUND: Oral diseases are among the major public health problems and the commonest of chronic diseases that affect mankind. The application of natural products for the control of oral diseases is considered as an interesting alternative to synthetic antimicrobials due to their lower negative impact, and for the effort to overcome primary or secondary resistance to the drug during therapy. OBJECTIVE: To review the current evidence on the antimicrobial efficacy of 10 plant extracts on dental caries and plaque microorganisms...
July 2015: Pharmacognosy Reviews
Niklas Rommel, Nils H Rohleder, Stefan Wagenpfeil, Roland Härtel-Petri, Frederic Jacob, Klaus-Dietrich Wolff, Marco R Kesting
OBJECTIVE: The use of methamphetamine (MA), a highly addictive stimulant, is rapidly increasing, with MA being widely abused as the scene drug "Crystal Meth" (CM). CM has been associated with severe oral health effects, resulting in so-called "Meth mouth". This term appeared for the first time in 2005 in the literature and describes the final complex of symptoms including rampant caries, periodontal diseases and excessive tooth wear. The aim of this study was to investigate the effects of chronic CM abuse on teeth and intraoral tissue with respect to potential symptoms of Meth mouth...
April 2016: Clinical Oral Investigations
Hajar Shekarchizadeh, Mohammad R Khami, Simin Z Mohebbi, Hamed Ekhtiari, Jorma I Virtanen
Oral health problems, among the most prevalent comorbidities related to addiction, require more attention by both clinicians and policy-makers. Our aims were to review oral complications associated with drugs, oral health care in addiction rehabilitation, health services available, and barriers against oral health promotion among addicts. Drug abuse is associated with serious oral health problems including generalized dental caries, periodontal diseases, mucosal dysplasia, xerostomia, bruxism, tooth wear, and tooth loss...
September 2013: Iranian Journal of Public Health
Andreas Zenthöfer, Peter Rammelsberg, Tomas Cabrera, Johannes Schröder, Alexander Jochen Hassel
BACKGROUND: Diminished oral health of the institutionalized elderly has frequently been reported. This is not only of significance with regard to nutrition and general health, but it can also affect oral health-related quality of life. This paper evaluates the effects of oral and general conditions on oral health-related quality of life for the institutionalized elderly, as measured by the Geriatric Oral Health Assessment Index (GOHAI). MATERIALS AND METHODS: Ninety-four residents of four long-term care homes in southern Germany agreed to participate in this study, and interviews were conducted using the GOHAI questionnaire...
December 2014: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
Ruchi Banthia, Santosh Gupta, Priyank Banthia, Pallavi Singh, Sapna Raje, Navkiran Kaur
BACKGROUND: Gingival overgrowth is a common side-effect of amlodipine regimen on the oral cavity. There is controversy regarding the cause and effect relationship of periodontal health and drug induced gingival overgrowth. Therefore, this study was conducted to investigate and to assess the relationship between the periodontal health and the onset and severity of gingival overgrowth in hypertensive patients receiving amlodipine. MATERIALS AND METHODS: A total of 99 known hypertensive patients on amlodipine regimen were included in this study...
September 2014: Dental Research Journal
Antônio Augusto Moura da Silva, Vanda Maria Ferreira Simões, Marco Antonio Barbieri, Viviane Cunha Cardoso, Claudia Maria Coelho Alves, Erika Bárbara Abreu Fonseca Thomaz, Rejane Christine de Sousa Queiroz, Ricardo Carvalho Cavalli, Rosângela Fernandes Lucena Batista, Heloísa Bettiol
BACKGROUND: Preterm birth is the main cause of morbidity and mortality during the perinatal period. Classical risk factors are held responsible for only 1/3 of preterm births and no current intervention has produced an appreciable reduction of this event. It is necessary to explore new hypotheses and mechanisms of causality by using an integrated approach, collaboration among research groups and less fragmented theoretical-methodological approaches in order to detect new risk factors and to formulate more effective intervention strategies...
2014: Reproductive Health
Lynn Roosa Friesen, Mary P Walker, Rebecca E Kisling, Ying Liu, Karen B Williams
This study evaluated second-, third-, and fourth-year dental students' ability to identify systemic conditions associated with periodontal disease, risk factors most important for referral, and medications with an effect on the periodontium and their ability to apply this knowledge to make clinical decisions regarding treatment and referral of periodontal patients. A twenty-one question survey was administered at one U.S. dental school in the spring semester of 2012 to elicit the students' knowledge and confidence regarding clinical reasoning...
September 2014: Journal of Dental Education
Michael Wolf, Alexander Wurm, Friedhelm Heinemann, Thomas Gerber, Christoph Reichert, Andreas Jäger, Werner Götz
PURPOSE: Maxillary sinus floor augmentation is a treatment that has been proposed for patients in whom the alveolar bone height is insufficient. This procedure is commonly used in patients aged 40 to 70 years and older. However, little information exists whether the factor of age might influence the outcome of augmentation procedures. The aim of this study was to investigate whether the patient's age has an effect on bone formation and incorporation in maxillary sinus floor augmentation procedures...
July 2014: International Journal of Oral & Maxillofacial Implants
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