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Systemic conditions and periodontal health

Sidónio C Freitas, Alejandra Correa-Uribe, M Cristina L Martins, Alejandro Pelaez-Vargas
Implant-based therapy is a mature approach to recover the health conditions of patients affected by edentulism. Thousands of dental implants are placed each year since their introduction in the 80s. However, implantology faces challenges that require more research strategies such as new support therapies for a world population with a continuous increase of life expectancy, to control periodontal status and new bioactive surfaces for implants. The present review is focused on self-assembled monolayers (SAMs) for dental implant materials as a nanoscale-processing approach to modify titanium surfaces...
2018: International Journal of Dentistry
Ronaldo Lira-Junior, Sigvard Åkerman, Björn Klinge, Elisabeth A Boström, Anders Gustafsson
BACKGROUND: Analysis of saliva is emerging as a promising tool to diagnose and monitor diseases which makes determination of the salivary microbial profile in different scenarios essential. OBJECTIVE: To evaluate the effects of age, periodontal disease, sex, smoking, and medical conditions on the salivary microbial profile. DESIGN: A randomly selected sample of 441 individuals was enrolled (51% women; mean age 48.5±16.8). Participants answered a health questionnaire and underwent an oral examination...
2018: PloS One
James D Beck, Kevin L Moss, Thiago Morelli, Steven Offenbacher
BACKGROUND: This paper focuses on the Periodontal Profile Class (PPC) System that may be more informative and representative of periodontitis phenotypes than current case definitions of periodontitis. This study illustrates the unique aspects of the PPC compared with other periodontal indices for studying associations between periodontal disease and prevalent systemic conditions. METHODS: We computed odds ratios and 95% confidence intervals to compare associations between periodontal disease and prevalent systemic conditions using our new PPC and two traditional indices...
February 2018: Journal of Periodontology
Filippo Graziani, Nicola Discepoli, Stefano Gennai, Dimitra Karapetsa, Marco Nisi, Lea Bianchi, Nanning A Martijn Rosema, Ubele Van der Velden
BACKGROUND: To assess the nutraceutical effects of twice/daily intake of kiwifruit on periodontal parameters and systemic health before and after initial periodontal treatment (IPT). METHODS: At baseline, participants were randomly assigned to test and control group, and either consumed two kiwifruits/day for 5 months or no kiwifruit. In the first 2 months, no periodontal treatment was delivered (2 M). Subsequently, a session of full-mouth IPT within 24 hours was performed...
February 22, 2018: Journal of Periodontology
N Miyoshi, T Tanigawa, S Nishioka, K Maruyama, E Eguchi, K Tanaka, I Saito, K Yamazaki, Y Miyake
BACKGROUND AND OBJECTIVE: Salivary lactate dehydrogenase (LDH) was reported to be a useful parameter for the screening of periodontal disease. We performed a cross-sectional study to verify the usefulness of salivary LDH as a biomarker of periodontitis and to investigate the association of severity of periodontitis with systemic inflammation by measuring salivary LDH and serum high sensitive C-reactive protein (hs-CRP) levels in a community-based middle-aged and elderly population in Japan...
February 15, 2018: Journal of Periodontal Research
T Zhang, J Wu, N Ungvijanpunya, O Jackson-Weaver, Y Gou, J Feng, T V Ho, Y Shen, J Liu, S Richard, J Jin, G Hajishengallis, Y Chai, J Xu
The balance between pro- and anti-inflammatory signals maintains tissue homeostasis and defines the outcome of chronic inflammatory diseases such as periodontitis, a condition that afflicts the tooth-supporting tissues and exerts an impact on systemic health. The induction of tissue inflammation relies heavily on Toll-like receptor (TLR) signaling, which drives a proinflammatory pathway through recruiting myeloid differentiation primary response gene 88 (MyD88) and activating nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB)...
February 1, 2018: Journal of Dental Research
Yvonne Mödinger, Bettina Löffler, Markus Huber-Lang, Anita Ignatius
An integral part of innate immunity is the complement system, a defence system, consisting of fluid-phase and cell surface-bound proteins. Its role to ensure adequate responses to danger factors and thus promoting host defence against pathogens has been well described already for decades. Recently, numerous further reaching functions of complement have been discovered, among these are tissue homeostasis and regeneration, also with respect to the skeletal system. The influence of complement activation on bone was recognised first in pathological conditions of inflamed bone tissue and surrounding areas, observed, for example, in rheumatoid arthritis and osteoarthritis...
January 29, 2018: Seminars in Immunology
Marta Zambon, Chiara Mandò, Alessandra Lissoni, Gaia Maria Anelli, Chiara Novielli, Manuela Cardellicchio, Roberto Leone, Marta Noemi Monari, Maddalena Massari, Irene Cetin, Silvio Abati
BACKGROUND: Maternal obesity is related to immunologic and inflammatory systemic modifications that may worsen the pregnancy inflammatory status. Hormonal changes during pregnancy can adversely affect oral biofilms and oral health initiating or worsening periodontal diseases, with enhanced local and systemic oxidative stress and inflammation. OBJECTIVE: The aim of this study was to examine the relationship between local salivary and systemic parameters of oxidative stress and inflammation in relation to obesity and periodontal diseases...
January 1, 2018: Reproductive Sciences
Salwa A AlSadhan, Asma M Al-Jobair, Mariam Bafaqeeh, Hanadi Abusharifa, Maram Alagla
BACKGROUND: The impact of visual impairment on oral health in the literature is inconclusive, and the available information on the medical and dental health status of visually impaired children is limited. The aim of this study was to evaluate the dental and medical health status, and to assess the oral health knowledge of visually impaired girls aged 6-12 years, and compare them to that of sighted children. METHODS: This analytical cross-sectional study was carried out on 79 visually impaired and 83 age-matched sighted female primary school children...
December 19, 2017: BMC Oral Health
Ina Manuela Schüler, Stefanie Haberstroh, Kristin Dawczynski, Thomas Lehmann, Roswitha Heinrich-Weltzien
AIM: Assessment of dental health in the primary dentition of preterm infants (PTI) including investigation of mother- and infant-related risk factors in a case-control study design. MATERIAL AND METHODS: One hundred twenty-eight infants aged 3-4 years were included. Sixty-four PTI (27 males) were randomly selected from the preterm registry of the Jena University Hospital. As a control group served 64 full-term infants (FTI) recruited from the Department of Paediatric Dentistry, matched for age and sex...
2018: Caries Research
Sheila C Cortelli, Fernando O Costa, Antonio Gargioni-Filho, Davi R Aquino, Luis O M Cota, Alexandre P Scherma, Taís B Miranda, Jose R Cortelli
OBJECTIVES: Patients with diabetes have a poor oral health-related quality of life (OHRQoL). It is not clear if this situation could be changed with effective periodontal treatment. This study examined both patients with diabetes and systemically healthy individuals to discover the impact of a gingivitis treatment protocol on OHRQoL and its relation to objective periodontal parameters. DESIGN: After ultrasonic debridement, patients were randomly assigned to an essential-oils (EO) or placebo mouthwash group...
February 2018: Archives of Oral Biology
Vijendra P Singh, Sunil K Nettemu, Sowmya Nettem, Rajesh Hosadurga, Sangeeta U Nayak
Ample evidence strongly supports the fact that periodontal disease is a major risk factor for various systemic diseases namely cardio-vascular disease, diabetes mellitus, etc. Recently, investigators focussed on exploring the link between chronic periodontitis (CP) and erectile dysfunction (ED) by contributing to the endothelial dysfunction. Both the diseases share common risk factors. Various studies conducted in different parts of the world in recent years reported the evidence linking this relationship as well as improvement in ED with periodontal treatment...
July 2017: Journal of Human Reproductive Sciences
A V Kislitsyna, A G Volkov, N Zh Dikopova, S S Akhmedbaeva, A L Shishmareva
Playing various musical instruments is the cause of an additional load that affects the condition of dentition and of all organs and body systems at large. Each group of instruments is known to exert a specific impact on the health of the musicians including the undesirable influence on the state of thir oral cavity, such as a change of occlusion and irritation of oral mucosa. Taken together, these effects contribute to the development of periodontal disease, one of the most common dental disorders. AIM: The objective of the present study was to evaluate the effectiveness of ozone therapy conducted with the use of the generator producing ozone under effect of ultraviolet radiation for the treatment of periodontitis in musicians-instrumentalists...
2017: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
Anna B Pritchard, StJohn Crean, Ingar Olsen, Sim K Singhrao
As far back as the eighteenth and early nineteenth centuries, microbial infections were responsible for vast numbers of deaths. The trend reversed with the introduction of antibiotics coinciding with longer life. Increased life expectancy however, accompanied the emergence of age related chronic inflammatory states including the sporadic form of Alzheimer's disease (AD). Taken together, the true challenge of retaining health into later years of life now appears to lie in delaying and/or preventing the progression of chronic inflammatory diseases, through identifying and influencing modifiable risk factors...
2017: Frontiers in Aging Neuroscience
Shawn F Kane
The oral cavity is the intersection of medicine and dentistry and the window into the general health of a patient. Hundreds of diseases and medications impact the oral cavity, and pathologic conditions in the mouth have a greater systemic impact than many providers appreciate. It is unclear whether there is true causality or just an association between periodontal disease and certain other systemic conditions, including atherosclerotic vascular disease, pulmonary disease, diabetes, pregnancy-related complications, osteoporosis, and kidney disease...
November 2017: General Dentistry
Yi-Da Wu, Ching-Heng Lin, Wen-Cheng Chao, Tsai-Ling Liao, Der-Yuan Chen, Hsin-Hua Chen
OBJECTIVE: To examine the association between a history of periodontitis (PD) and incident systemic lupus erythematosus (SLE). METHODS: We used 2003-2012 claims data from the Taiwanese National Health Insurance Database to identify 7,204 incident SLE patients during 2007-2012 as the study group, along with randomly selecting 72,040 non-SLE patients matched (1:10) for age, gender, and first diagnosis date (index date) as the control group. The correlation between PD and SLE risk was estimated using conditional logistic regression analysis, after making adjustments for confounders (including a history of diabetes and number of non-PD related dental visits before the index date)...
2017: PloS One
Aishah Alhodhodi, Hanaa Alkharobi, Matthew Humphries, Hasanain Alkhafaji, Reem El-Gendy, Georg Feichtinger, Valerie Speirs, James Beattie
Estradiol (E2 ) has many important actions in the tissues of the oral cavity. Disruption of E2 metabolism or alterations in systemic E2 concentrations have been associated with compromised periodontal health. In many instances such changes occur secondarily to the well characterised effects of E2 on bone physiology -especially maintenance of bone mineral density (BMD). Despite these important epidemiological findings, little is known about the mechanism of action of E2 in oral tissues or the expression and function of oestrogen receptor (ER) isoforms in these tissues...
November 2017: Journal of Steroid Biochemistry and Molecular Biology
Christof Dörfer, Christoph Benz, Jun Aida, Guillaume Campard
Oral health is closely related to systemic health. Periodontitis, a chronic inflammatory disease which is highly prevalent worldwide, interacts with a variety of noncommunicable diseases (NCDs). It is a risk factor in the complex pathogenesis of diabetes mellitus and cardiovascular disease and plays a role in the development of endocarditis and recurrent pneumonia in elderly people. However, the available data may be interpreted in different ways, and more and better-designed studies are still needed to answer relevant questions about the causal role of periodontitis in NCDs...
September 2017: International Dental Journal
Elisa M Chávez, Amruta Hendre
Pathologic changes in the oral cavity can portend the presence of systemic diseases and result in poor oral health and tooth loss, which are commonly symbolic of aging. Systemic diseases can have direct and indirect effects on oral health, and, likewise, poor oral health can impact general health and wellbeing. Negligence in oral care results in the accumulation of dental plaque and calculus, which eventually contributes to the onset of dental caries, periodontal disease, halitosis, tooth loss, and, ultimately, diminished oral function...
October 2017: Compendium of Continuing Education in Dentistry
Noha Gomaa, Belinda Nicolau, Arjumand Siddiqi, Howard Tenenbaum, Michael Glogauer, Carlos Quiñonez
OBJECTIVES: To evaluate the extent of association between systemic inflammation and periodontal disease in American adults, and to assess whether socio-economic position mediated this relationship. METHODS: We used data from the National Health and Nutrition Examination Survey (NHANES IV) (2001-2010). Systemic inflammation was defined by individual and aggregate (cumulative inflammatory load) biomarkers (C-reactive protein, white blood cell counts, neutrophil counts, and neutrophil:lymphocyte ratio)...
September 14, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
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