Read by QxMD icon Read

Inflammatory Arthritis ANA Positive

José Miguel Tricás-Moreno, María Orosia Lucha-López, Ana Carmen Lucha-López, Carlos Salavera-Bordás, Concepción Vidal-Peracho
[Purpose] Ankylosing spondylitis is prevalent in men. Modern and expert consensus documents include physical therapy among the strategies for the treatment of ankylosing spondylitis. This study aimed to describe the physical therapy approach in an athlete with ankylosing spondylitis. [Subject and Methods] The patient, refractory to treatment with anti-inflammatory medication, showed pelvic and lumbar pain and joint, muscle, and functional disorders, which were treated with orthopedic joint mobilization, dry needling, exercise, and whole-body hyperthermia...
April 2016: Journal of Physical Therapy Science
Hana Jedlickova, Veronika Durčanská, Vladimír Vašků
Dear Editor, Scleroderma associated with neoplasia is rare, with only a small number of cases reported. We describe 4 patients with paraneoplastic scleroderma who were treated at the I. Department of Dermatovenereology, St. Anna Hospital, during the period between 2004 and 2014. The patients were diagnosed with cholangiogenic carcinoma, endometrial carcinoma, prostatic adenocarcinoma, and adenoma of the suprarenal gland. In the case of concurrent scleroderma and tumor, four situations may occur: they can develop independently of each other; scleroderma may be induced by the tumor; the tumor can develop in the scleroderma; or the tumor can be induced by immunosuppressive therapy...
April 2016: Acta Dermatovenerologica Croatica: ADC
M Wahle, E Kling
Immunodiagnostics play an important role in the differential diagnostics of arthritis but the test results must be interpreted with respect to the clinical context. The detection of antibodies against citrullinated proteins has significantly improved the immunodiagnostics of arthritis, whereas the importance of testing for rheumatoid factor has decreased due to the low specificity. Antibodies against carbamylated or oxidized proteins will expand the immunodiagnostics of arthritis (especially rheumatoid arthritis) in the future...
May 2016: Zeitschrift Für Rheumatologie
João Luiz Pereira Vaz, Vander Fernandes, Felipe Nogueira, Adriano Arnóbio, Roger A Levy
The purpose of this study was to assess autoantibody incidence in patients treated with infliximab for various diseases, and the development of autoimmune diseases using a multicenter, longitudinal, open-label, phase IV observational study. All patients received anti-tumor necrosis factor (anti-TNF) according to local treatment guidelines. The autoantibodies assessed before and after infliximab treatment were ANA, anti-Sm, anti-dsDNA, anticardiolipin IgM/IgG, anti-Scl70, anti-centromere B, anti-chromatin, anti-ribosomal P, anti-Sm-RNP, anti-RNP A, anti-RNP 68 kD, anti-La/SSB, anti-Ro/SSA 52 kD and 60 kD, and anti-Jo1...
February 2016: Clinical Rheumatology
Viera Kalinina Ayuso, Marijke R van Dijk, Joke H de Boer
PURPOSE: We investigated inflammatory cell infiltrates in iris biopsies in uveitis associated with juvenile idiopathic arthritis (JIA) in comparison with other pediatric uveitis entities and noninflammatory pediatric controls. METHODS: Iridectomy specimens were obtained during elective trabeculectomy from 31 eyes of 25 patients: 12 eyes with JIA-associated uveitis, 13 eyes with other uveitis entities, and 6 eyes with open angle nonuveitic juvenile glaucoma. Histopathologic and immunohistochemical analyses were performed...
October 2015: Investigative Ophthalmology & Visual Science
C Tappeiner, J Klotsche, S Schenck, M Niewerth, K Minden, A Heiligenhaus
OBJECTIVES: To analyse the nationwide prevalence of uveitis in JIA and its complications over a whole decade. METHODS: We conducted a prospective, observational and cross-sectional study including all JIA patients from a National Paediatric Rheumatological Database (NPRD) with a uveitis add-on module in Germany (2002-2013). Temporal changes in uveitis prevalence, related secondary complications and anti-inflammatory medication were evaluated. RESULTS: A total of 60 centres including 18,555 JIA patients (mean 3,863 patients/year, SD=837) were documented in the NPRD between 2002 and 2013...
November 2015: Clinical and Experimental Rheumatology
Erin Nevius, Ana Cordeiro Gomes, João P Pereira
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that primarily affects the joints. Self-reactive B and T lymphocytes cooperate to promote antibody responses against self proteins and are major drivers of disease. T lymphocytes also promote RA independently of B lymphocytes mainly through the production of key inflammatory cytokines, such as IL-17, that promote pathology. While the innate signals that initiate self-reactive adaptive immune responses are poorly understood, the disease is predominantly caused by inflammatory cellular infiltration and accumulation in articular tissues, and by bone erosions driven by bone-resorbing osteoclasts...
August 2016: Clinical Reviews in Allergy & Immunology
Paz Zuberbuhler, Pablo Young, Luciana V León Cejas, Bárbara C Finn, Julio E Bruetman, Cristian R Calandra, Ernesto Fulgenzi, Manuel Pérez Akly, Alejandro Rodríguez, Ana Pardal, Ricardo Reisin
Sensory neuronopathies or ganglionopathies, or dorsal root ganglion disorders, represent a subgroup of peripheral nervous system diseases, frequently associated with dysinmune or neoplastic disorders and with toxic agents. A degeneration of both central and peripheral sensory proyections is present. Patients typically show early ataxia, loss of deep tendon reflexes and positive sensory symptoms present both in proximal and distal sites of the body. We retrospectively studied 10 cases with a final diagnosis of sensory neuronopathy...
2015: Medicina
Ariane Carla Horiuchi, Luiz Henrique Cardoso Pereira, Bárbara Stadler Kahlow, Marilia Barreto Silva, Thelma L Skare
BACKGROUND: The age of onset of rheumatoid arthritis (RA) appears to be a determining factor in differences in disease presentation. OBJECTIVE: To study the clinical, demographic and treatment characteristics of patients with elderly onset rheumatoid arthritis (Eora) and to compare them to those with younger onset rheumatoid arthritis (Yora) patients. METHODS: We studied 62 patients with Eora and 111 with Yora for gender, presence of rheumatoid nodules, interstitial pneumonitis, tobacco exposure, rheumatoid factor (RF) and antinuclear antibodies (ANA), medications, functional index measured by Health Assessment Questionnaire (HAQ) and inflammatory activity measured by DAS (Disease Activity Score) 28...
September 14, 2015: Revista Brasileira de Reumatologia
Ana Urruticoechea-Arana, María A Martín-Martínez, Santos Castañeda, Carlos A Sanchez Piedra, Carlos González-Juanatey, Javier Llorca, Federico Díaz-Gonzalez, Miguel A González-Gay
INTRODUCTION: The aim was to study the association between 25-hydroxyvitamin D (25(OH)D) levels and the clinical characteristics of patients with chronic inflammatory rheumatic diseases (CIRD). METHODS: We studied a cross-section from the baseline visit of the CARMA project (CARdiovascular in rheuMAtology), a 10-year prospective study evaluating the risk of cardiovascular events in rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) patients, and non-CIRD patients who attended rheumatology outpatient clinics from 67 hospitals in Spain...
2015: Arthritis Research & Therapy
Juliane Scholz, Kai Grossmann, Ilka Knütter, Rico Hiemann, Mandy Sowa, Nadja Röber, Stefan Rödiger, Peter Schierack, Dirk Reinhold, Dimitrios P Bogdanos, Pier Luigi Meroni, Antonella Radice, Karsten Conrad, Dirk Roggenbuck
BACKGROUND: For the serological diagnosis of systemic autoimmune rheumatic diseases, a two-tier approach starting with sensitive antinuclear antibody (ANA) detection by indirect immunofluorescence (IIF) on HEp-2 cells followed by characterization of positive findings with different immunoassays is recommended. To overcome drawbacks of this approach, we developed a novel technique allowing the combination of screening and simultaneous confirmatory testing. For the first time, this creates the basis for second generation ANA testing...
November 2015: Clinical Chemistry and Laboratory Medicine: CCLM
Alicia Santos Savio, Ana Cecilia Machado Diaz, Araceli Chico Capote, Jamilet Miranda Navarro, Yunier Rodríguez Alvarez, Ricardo Bringas Pérez, Miguel Estévez del Toro, Gerardo E Guillen Nieto
BACKGROUND: Pro-inflammatory cytokines are directly implicated in the pathogenesis of Rheumatoid arthritis (RA). Variable clinical response to cytokine targeted therapies as TNFalpha and IL-6, strongly highlights the heterogeneity of inflammatory process in RA. Another cytokine, IL-15 has also been related to the inflammatory process in RA. Recently we described for the first time, the presence of its specific receptor, IL-15Ralpha, in synovial fluid (SF). The aim of this work was to compare the expression profile of IL-15Ralpha, its ligand IL-15, TNFalpha and IL-6 and how these cytokines are correlated in SF from RA patients taking as a reference Osteoarthritis (OA), an articular but not autoimmune disease...
2015: BMC Musculoskeletal Disorders
Senol Kobak, Hatice Yilmaz, Fidan Sever, Arzu Duran, Nazime Sen, Ahmet Karaarslan
Introduction. Sarcoidosis, which is a chronic inflammatory granulomatous disease, can mimic different rheumatologic diseases including connective tissue diseases. Antinuclear antibodies are the markers used for connective tissue diseases. Aim. To determine antinuclear antibody frequency and any possible correlation with clinical and laboratory data in sarcoidosis patients. Material and Method. Forty-two sarcoidosis patients, 45 rheumatoid arthritis patients, and 45 healthy volunteers who were followed up in rheumatology outpatient clinic were included in this study...
2014: Autoimmune Diseases
Shakeel Ahmed, Syed Rehan Ali, Sidra Ishaque, Nabil Sami
OBJECTIVE: To determine the clinical and biochemical characteristics of children with Juvenile Idiopathic Arthritis (JIA) at a tertiary care centre in Karachi, Pakistan. STUDY DESIGN: A descriptive study. PLACE AND DURATION OF STUDY: Paediatric Rheumatology Clinic of The Aga Khan University Hospital (AKUH), Karachi, from January 2008 to December 2011. METHODOLOGY: Clinical and laboratory profile and outcome of children less than 15 years of age attending the Paediatric Rheumatology Clinic of the Aga Khan University, Karachi with the diagnosis of Juvenile Idiopathic Arthritis according to International League against Rheumatism were studied...
July 2014: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Goitybell Martínez Téllez, Bárbara Torres Rives, Suchiquil Rangel Velázquez, Vicky Sánchez Rodríguez, María Antonia Ramos Ríos, Lisset Evelyn Fuentes Smith
OBJECTIVE: To determine positivity and clinical correlation of anti-neutrophil cytoplasmic antibodies (ANCA), taking into account the interference of antinuclear antibodies (ANA). MATERIAL AND METHODS: A prospective study was conducted in the Laboratory of Immunology of the National Cuban Center of Medical Genetic during one year. Two hounded sixty-seven patients with indication for ANCA determination were included. ANCA and ANA determinations with different cut off points and assays were determined by indirect immunofluorescense...
January 2015: Reumatología Clinica
Karoline Walscheid, Maren Hennig, Carsten Heinz, Susanne Wasmuth, Martin Busch, Dirk Bauer, Martha Dietzel, Cornelia A Deeg, Arnd Heiligenhaus
PURPOSE: The pathogenesis of juvenile idiopathic arthritis-associated uveitis (JIAU) is undefined. This study intended to analyze the presence of antiocular autoantibodies in serum and their correlation with disease course. METHODS: Serum samples from children with JIAU (n = 47); JIA without uveitis (n = 67); idiopathic anterior uveitis (IAU; n = 12); and healthy controls (n = 52) were collected. The binding patterns of serum antibodies to ocular cryosections from swine eyes were analyzed by indirect immunohistochemistry, and were correlated to epidemiological, clinical, and laboratory test results...
June 2014: Investigative Ophthalmology & Visual Science
Jonathan A Motts, Devon L Shirley, Ellen K Silbergeld, Jennifer F Nyland
Mercury is a ubiquitous environmental contaminant, causing both neurotoxicity and immunotoxicity. Given its ability to amalgamate gold, mercury is frequently used in small-scale artisanal gold mining. We have previously reported that elevated serum titers of antinuclear autoantibodies (ANA) are associated with mercury exposures of miners in gold mining. The goal of this project was to identify novel serum biomarkers of mercury-induced immunotoxicity and autoimmune dysregulation. We conducted an analysis of serum samples from a cross-sectional epidemiological study on miners working in Amazonian Brazil...
July 2014: Environmental Research
Mohammed Mustafa Moued, Hussain Mohsin Al-Saggaf, Hamed Said Habib, Mohammed Ahmed Muzaffer
BACKGROUND AND OBJECTIVES: Oligoarticular juvenile idiopathic arthritis (JIA) is the most frequent chronic inflammatory rheumatic condition in children. We aimed to describe the clinical and serological profile of Saudi patients with oligoarticular JIA. DESIGN AND SETTINGS: Hospital-based retrospective chart review of all children diagnosed with oligoarticular JIA and followed up at King Abdulaziz University Hospital between 1998 and 2012. PATIENTS AND METHODS: We reviewed the medical files of children with oligoarticular JIA and recorded the gender, age at presentation and diagnosis, clinical presentation, laboratory and radiological investigations, treatment administered, and disease complications...
November 2013: Annals of Saudi Medicine
Ariana Barberá, Noraylis Lorenzo, Greta Garrido, Yuliet Mazola, Viviana Falcón, Ana María Torres, María Isabel Hernández, María Victoria Hernández, Bram Margry, A Marit de Groot, Joel van Roon, Ruurd van der Zee, Femke Broere, Willem van Eden, Gabriel Padrón, María del Carmen Domínguez
Rheumatoid arthritis (RA) is a chronic T-cell mediated autoimmune disease that affects primarily the joints. The induction of immune tolerance through antigen-specific therapies for the blockade of pathogenic CD4+ T cells constitutes a current focus of research. In this focus it is attempted to simultaneously activate multiple regulatory mechanisms, such as: apoptosis and regulatory T cells (Tregs). APL-1 is an altered peptide ligand derived from a novel CD4+ T-cell epitope of human heat-shock protein of 60kDa, an autoantigen involved in the pathogenesis of RA...
December 2013: International Immunopharmacology
Antonio Vannini, Marco Fusconi, Anna Chiara Dall'Aglio, Francesco Tovoli, Magda Frisoni, Daniela Zauli
OBJECTIVES: erosive hand osteoarthritis (EHOA) is an inflammatory disorder involving joints of the hands, which may be accompanied by acute phase reactants. The relationship between EHOA and classical osteoarthritis (OA) is still controversial, since some authors consider EHOA as a distinct disease, other as a subset of OA, and some as a border entity between OA and rheumatoid arthritis (RA). Scarce data are available about the seroimmunological profile of the disease, which could aid to identify a possible role of the immune system in EHOA pathogenesis, and could also allow to better differentiate EHOA both from OA and RA...
January 2013: Acta Reumatológica Portuguesa
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"