Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
Emily R Littman, Kathleen Mccabe, Shazia Beg
Breast implants, whether silicone or saline-filled, have a silicone shell and have been used for decades. Studies have shown an association between silicon with systemic lupus erythematosus, rheumatoid arthritis, progressive systemic sclerosis, and vasculitis. However, controversy and inconsistency have been pervasive in the literature with respect to the role of breast implants in the development of autoimmune diseases. A 39-year-old female with a past medical history of breast cancer and a family history of Sjogren's syndrome was referred to rheumatology for positive antinuclear antibodies (ANA) and polyarthralgia...
February 2024: Curēus
#2
JOURNAL ARTICLE
Carolina Mazeda, Natacha Oliveira, Catarina Abreu, Vanessa Fraga, Isabel Maduro, André Saraiva, Luís Inês, Carla Ferreira, Ana Margarida Correia, Rafaela Nicolau, Filipa Farinha, Ingrid Villanueva, Diogo Jesus, Pedro Abreu, Agna Neto, Joana Silva Dinis, Anabela Barcelos
OBJECTIVES: Anti-SSA autoantibodies can be differentiated according to their antigenic target proteins as anti-Ro60 (60 kDa) or anti-Ro52 (52 kDa). Anti-SSA(Ro60) antibodies are clearly associated with connective tissue diseases (CTD), but the clinical significance of anti-SSA(Ro52) antibodies remains unclear. The aim of the present study was to analyse the disease phenotype of patients with anti-Ro52 and/or anti-Ro60 antibodies. METHODS: A multicentre, cross-sectional study was carried out of positive anti-Ro52 and/or Ro60 antibodies patients followed at 10 Rheumatology centres from January 2018 until December 2021...
March 26, 2024: Clinical and Experimental Rheumatology
#3
JOURNAL ARTICLE
Nada Shaker, Omar P Sangueza, Nuha Shaker, Megan Arthur, Dinesh Pradhan
Background. Fixed drug eruption and Rowell syndrome stand as intriguing entities with overlapping clinical and pathological features. Case Presentation . A 32-year-old female patient presented with a tender and pruritic rash on the left upper chest for 3 days. Clinical examination revealed a flaring rash on the chest, under her left eye, tongue, and lips. The patient had a significant past medical history of systemic lupus erythematous with positive (ANA, Sm, dsDNA, ribosomalP, RNP) antibodies, hypocomplementemia, inflammatory arthritis, discoid lupus, leukopenia, thrombocytopenia, and immune thrombocytopenic purpura, and avascular necrosis affecting both hips and her right knee...
March 18, 2024: International Journal of Surgical Pathology
#4
JOURNAL ARTICLE
Zhixiang Huang, Lixin Huang, Jiali Ding, Yukai Huang, Xuechan Huang, Tianwang Li
BACKGROUND: Osteophyte development is a common characteristic of inflammatory skeletal diseases. Elevated osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) participates in pathological osteogenesis. Integrin-linked kinase (ILK) positively regulates the osteoblastic differentiation of osteoprogenitors, but whether the ILK blockage prevents osteophytes and its potential mechanism is still unknown. Furthermore, the low-dose tumor necrosis factor-α (TNF-α) promotes osteogenic differentiation, but a lack of study reports on the relationship between this cytokine and ILK...
March 14, 2024: Molecular Biology Reports
#5
JOURNAL ARTICLE
Huimin Yang, Chao Sun, Xin Wang, Tao Wang, Changhao Xie, Zhijun Li
BACKGROUND: The labial salivary glands (LSGs) are important for the diagnosis, evaluation of therapeutic efficacy, and genetic analyses of primary Sjögren's syndrome (pSS). In autoimmune diseases, the recognition of self nucleic acids and viral RNA and DNA through endogenous Toll-like receptor(TLR) triggers the production of type I IFN and pro-inflammatory cytokines, leading to the occurrence and progression of the disease. Here, we detected the expression of TLR7 in LSGs and analyse its correlation with clinical features and serum cytokines in pSS patients...
March 4, 2024: Advances in Rheumatology
#6
JOURNAL ARTICLE
Beatriz Frade-Sosa, Andrés Ponce, Estíbaliz Ruiz-Ortiz, Noemí De Moner, María J Gómara, Ana Belén Azuaga, Juan C Sarmiento-Monroy, Rosa Morlà, Virginia Ruiz-Esquide, Laura Macías, Nuria Sapena, Lola Tobalina, Julio Ramirez, Juan D Cañete, Jordi Yague, Josep M Auge, José A Gomez-Puerta, Odette Viñas, Isabel Haro, Raimon Sanmarti
INTRODUCTION: This study assesses the accuracy of neutrophil activation markers, including neutrophil extracellular traps (NETs) and calprotectin, as biomarkers of disease activity in patients with established rheumatoid arthritis (RA). We also analyse the relationship between NETs and various types of therapies as well as their association with autoimmunity. METHODS: Observational cross-sectional study of patients with RA receiving treatment with biological disease-modifying antirheumatic drugs or Janus kinase inhibitors (JAK-inhibitors) for at least 3 months...
March 2, 2024: Rheumatology and Therapy
#7
JOURNAL ARTICLE
Hayde Guadalupe Hernández-Huirache, Dagoberto Armenta-Medina, Edel Rafael Rodea-Montero
INTRODUCTION: Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in childhood, affecting one to four of every 1000 children worldwide. It is characterized by joint inflammation lasting more than six weeks in children under 16 years. The aim of this study was to estimate the frequency of JIA subtypes in the Mexican patient population; compare clinical, immunological and inflammation markers by JIA subtype; and examine the correlation between these variables...
February 7, 2024: Pediatric Reports
#8
JOURNAL ARTICLE
Ana Valle, Sonali Narain, Maria-Louise Barilla-Labarca, Galina Marder
OBJECTIVE: In idiopathic inflammatory myopathies, anti-SSa/SSb and anti-Ro52 are associated with interstitial lung disease (ILD), yet few studies have compared their prognostic utility. Our study analyzes clinical phenotypes associated with anti-SSa/SSb and anti-Ro52 positivity in IIM and their association with ILD. METHODS: We performed a retrospective analysis of IIM patients >18-years-old, seen at Northwell Myositis Center 2007- 2018 who met 2017 EULAR/ACR criteria with available anti-SSa/SSb data...
February 8, 2024: Seminars in Arthritis and Rheumatism
#9
JOURNAL ARTICLE
Andrés Pazos-Pérez, María Piñeiro-Ramil, Eloi Franco-Trepat, Ana Alonso-Pérez, María Guillán-Fresco, Antía Crespo-Golmar, Miriam López-Fagúndez, Javier Conde Aranda, Susana Belen Bravo, Alberto Jorge-Mora, Rodolfo Gómez
OBJECTIVES: This study investigates the role of retinol binding protein 4 (RBP4) in an articular context. RBP4, a vitamin A transporter, is linked to various metabolic diseases. METHODS: Synovial fluid RBP4 levels were assessed in crystalline arthritis (CA) patients using ELISA. RBP4's impact on articular cell types was analysed in vitro through RT-PCR and flow cytometry. Proteomic analysis was conducted on primary human osteoarthritis chondrocytes (hOACs). RESULTS: Synovial fluid RBP4 concentrations in CA patients correlated positively with glucose levels and negatively with synovial leukocyte count and were elevated in hypertensive patients...
January 19, 2024: Antioxidants (Basel, Switzerland)
#10
JOURNAL ARTICLE
Carmen Álvarez-Reguera, Diana Prieto-Peña, Alba Herrero-Morant, Lara Sánchez-Bilbao, Ana Batlle-López, Sara Fernández-López, Nerea Paz-Gandiaga, Ricardo Blanco
OBJECTIVE: The Janus Kinase (JAK) 2 (V617F) mutation is the most frequently detected in myeloproliferative neoplasms (MPN). JAK2(V617F) mutation displays a pro-inflammatory phenotype that may be associated to a higher risk of immune mediated diseases (IMIDs), thromboembolic complications or other cancers. We aimed to evaluate the prevalence and main features of both rheumatic and non-rheumatic IMIDs in a cohort of MPNs patients with JAK2 (V617F) mutation. METHODS: Study of all patients diagnosed with MPNs and JAK2 (V617F) mutation at a tertiary hospital in Northern Spain from 2004 to 2022...
December 2, 2023: European Journal of Internal Medicine
#11
JOURNAL ARTICLE
Di Zhang, Huijing Wang, Xinpeng Zhou, Jianguo Yang, Yuan Liu, Wenjing Wang, Ping Jiang, Bing Fan
OBJECTIVES: To identify the differences of clinical characteristics, laboratory findings, and the long-term outcomes in patients with anti-synthetase syndrome (ASS) of different anti-aminoacyl-transfer RNA synthetase antibodies. METHODS: We retrospectively enrolled 119 patients with ASS, and the clinical characteristics and laboratory findings were collected. Additionally, multivariate COX regression analysis was performed to estimate the risk factors of prognosis in patients with ASS...
November 2023: Immunity, Inflammation and Disease
#12
JOURNAL ARTICLE
Pedro Ávila-Ribeiro, Ana Rita Lopes, Joana Martins-Martinho, Estela Nogueira, Joana Antunes, José Carlos Romeu, Ana Rita Cruz-Machado, Elsa Vieira-Sousa
CASE REPORT: A 68-year-old male treated with secukinumab for psoriatic arthritis suspended treatment for three months due to COVID pandemic. Upon secukinumab reintroduction, anorexia and weight loss ensued and four months later he had an abrupt onset of low-grade fever, fatigue, flu-like symptoms, dyspnoea and widespread inflammatory arthralgias. Laboratory investigations showed de novo anaemia, leukopenia, lymphopenia, cytocholestasis, elevated acute phase reactants, C3 complement consumption, proteinuria (1630mg/24h), active urine sediment, positive antinuclear (1:1280) and anti-double-stranded DNA (212...
2023: ARP Rheumatol
#13
JOURNAL ARTICLE
Emma Reesor, Sankalp Virendrakumar Bhavsar
The overlap of rheumatoid arthritis and systemic lupus erythematosus is well described, with a syndrome known as 'rhupus'. ANCA-associated vasculitis, however, is uncommonly associated with other autoimmune conditions. Here we present a case of lupus, rheumatoid arthritis, and ANCA-associated vasculitis, with significant time elapsed between presentations, resulting in an accumulation of the three diagnoses over the course of 35 years. The patient was diagnosed with lupus at age 45, presenting with inflammatory polyarthritis, thrombocytopenia, leukopenia, positive ANA, positive anti-DNA, and hypocomplementemia...
October 7, 2023: Modern rheumatology case reports
#14
JOURNAL ARTICLE
Mounib M Sabounji, Hilaire Lissimo, Amina Deme
BACKGROUND: Childhood-onset rheumatoid arthritis (CORA), known as rheumatoid factor (RF)-positive juvenile idiopathic arthritis is a type of juvenile idiopathic arthritis that shares the same genetic factors and clinical features as adult-onset rheumatoid arthritis. In Africa, CORA hasn't been the subject of a specific study. OBJECTIVES: The aim of this study is to describe the clinical features, disease activity, functional disability, and treatment of CORA at diagnosis in Senegal and compare the findings to other CORA populations...
September 12, 2023: Pediatric Rheumatology Online Journal
#15
JOURNAL ARTICLE
Jose Manuel Mascaro, Ignasi Rodriguez-Pinto, Gabriela Poza, Anna Mensa-Vilaro, Julian Fernandez-Martin, Luis Caminal-Montero, Gerard Espinosa, Jose Hernández-Rodríguez, Marina Diaz, Joana Rita-Marques, Raimon Sanmarti, Santos Castañeda, Dolores Colunga, Rubén Coto-Hernández, Patricia Fanlo, Jose Ignacio Elejalde, Segundo Bujan, Ignasi Figueras, Francisco Manuel Marco, Mariano Andrés, Silvia Suárez, Andres Gonzalez-Garcia, Xavier Fustà-Novell, Clara Garcia-Belando, Ana Granados, Maria Teresa Fernandez-Figueras, Neus Quilis, Maria Orriols-Caba, Ricardo Gómez de la Torre, Maria Cinta Cid, Georgina Espígol-Frigolé, Alba Alvarez-Abella, Eztizen Labrador, Maria Rozman, Monica Lopez-Guerra, Paola Castillo, Jose R Alamo-Moreno, Eva Gonzalez-Roca, Susana Plaza, Virginia Fabregat, Rocio Lara, Esther F Vicente-Rabaneda, Sonia Tejedor-Vaquero, Giuliana Magri, Nuria Bonet, Manuel Solis-Moruno, Andrea Cerutti, Oscar Fornas, Ferran Casals, Jordi Yagüe, Juan I Aróstegui
BACKGROUND: The vacuoles, E1-enzyme, X linked, autoinflammatory and somatic (VEXAS) syndrome is an adult-onset autoinflammatory disease (AID) due to postzygotic UBA1 variants. OBJECTIVES: To investigate the presence of VEXAS syndrome among patients with adult-onset undiagnosed AID. Additional studies evaluated the mosaicism distribution and the circulating cytokines. METHODS: Gene analyses were performed by both Sanger and amplicon-based deep sequencing...
December 2023: Annals of the Rheumatic Diseases
#16
REVIEW
Ana T Rufino, Marisa Freitas, Carina Proença, José M P Ferreira de Oliveira, Eduarda Fernandes, Daniela Ribeiro
Rheumatoid arthritis (RA) is a progressive, chronic, autoimmune, inflammatory, and systemic condition that primarily affects the synovial joints and adjacent tissues, including bone, muscle, and tendons. The World Health Organization recognizes RA as one of the most prevalent chronic inflammatory diseases. In the last decade, there was an expansion on the available RA therapeutic options which aimed to improve patient's quality of life. Despite the extensive research and the emergence of new therapeutic approaches and drugs, there are still significant unwanted side effects associated to these drugs and still a vast number of patients that do not respond positively to the existing therapeutic strategies...
August 21, 2023: Medicinal Research Reviews
#17
JOURNAL ARTICLE
Chamaida Plasencia-Rodríguez, Ana Martínez-Feito, Marta Hernández, Lucia Del Pino-Molina, Marta Novella-Navarro, Yolanda Serrano, Miguel González-Muñoz, Diana Peiteado, Gema Bonilla, Irene Monjo, Laura Nuño, Carolina Tornero, Eduardo López-Granados, Alejandro Balsa, Pilar Nozal
BACKGROUND: Real world data on the response to the SARS-CoV-2 vaccine in patients with immunomediated diseases (IMIDs) treated with immunesuppressants is of great interest because vaccine response may be impaired. The main aim was to study the humoral and cellular immune response after SARS-CoV-2 vaccination in patients with IMIDs treated with immunosuppressants. The secondary aim was to describe the frequency of SARS-CoV-2 infections after vaccination in these patients. MATERIAL AND METHODS: This is an observational study including 86 patients with IMIDs...
August 19, 2023: Allergy, Asthma, and Clinical Immunology
#18
JOURNAL ARTICLE
Stephanie C Osinchuk, Bruce H Grahn, Tracy D Wilson, Brooke N Thompson, David A Hart, Kim D Harrison, David Ml Cooper, Arash Panahifar, Alan M Rosenberg
Chronic asymptomatic and acute symptomatic anterior uveitis are forms of ocular inflammation associated with juvenileidiopathic arthritis (JIA) Chronic JIA-associated uveitis is characterized by young age of onset, female predilection, oligoarthritis,and antinuclear antibody (ANA) positivity. Acute JIA-associated uveitis predominantly affects older male juvenileswho also develop enthesitis. A type I collagen-derived peptide (melanin-associated antigen [MAA]) induces anterior uveitisin rodents. In this study, we evaluated MAA-induced uveitis in rats as a potential model for JIA-uveitis...
August 7, 2023: Comparative Medicine
#19
REVIEW
Chiara Alfia Ferrara, Gaetano La Rocca, Giuseppe Ielo, Alessandro Libra, Gianluca Sambataro
Mixed Connective Tissue Disease (MCTD) is an autoimmune disease first described by Sharp et al in 1972, characterized by the presence of anti-Ribonucleoprotein antibodies directed against the U1 complex (anti-U1RNP). The condition shares clinical characteristics with Systemic Lupus Erythematosus, Rheumatoid Arthritis, and Systemic Sclerosis. Diagnosis is quite difficult due to its rarity, the lack of validated classification criteria, and its heterogeneous clinical presentation. While in the early stages its nuanced clinical features might lead to it being incorrectly classified as other Connective Tissue Diseases (CTDs) or even not recognized, in cases of longstanding disease its classification as a CTD is clear but challenging to discriminate from overlap syndromes...
2023: ImmunoTargets and Therapy
#20
JOURNAL ARTICLE
Karina Rossi Bonfiglioli, Ana Cristina de Medeiros Ribeiro, Ana Paula Carnieletto, Ivânio Pereira, Diogo Souza Domiciano, Henrique Carriço da Silva, Alisson Pugliesi, Leticia Rocha Pereira, Maria Fernanda Resende Guimarães, Rina Dalva Neubarth Giorgi, Ana Paula Monteiro Gomides Reis, Claiton Viegas Brenol, Paulo Louzada-Júnior, Maria de Fátima Lobato da Cunha Sauma, Sebastião Cezar Radominski, Licia Maria Henrique da Mota, Geraldo da Rocha Castelar-Pinheiro
INTRODUCTION: Although Rheumatoid Arthritis (RA) extra-articular manifestations (ExtRA) occurrence has been decreasing over time, they are still a major mortality risk factor for patients. OBJECTIVE: To determine the prevalence of ExtRA in a large cohort, and its association with demographic and clinical variables. METHOD: Cross-sectional and observational study, based on a multi-centric database from a prospective cohort, in which 11 public rheumatology centres enrolled RA patients (1987 ARA or 2010 ACR-EULAR)...
July 26, 2023: Advances in Rheumatology
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
