Lorenzo Giosa, Francesco Zadek, Mattia Busana, Giovanna De Simone, Serena Brusatori, Martin Krbec, František Duška, Paolo Brambilla, Alberto Zanella, Alessandra Di Masi, Pietro Caironi, Emanuele Perez, Luciano Gattinoni, Thomas Langer
It is commonly assumed that changes in plasma strong ion difference (SID) result in equal changes in whole-blood base excess (BE). However, at varying pH, albumin ionic-binding and transerythrocyte shifts alter the SID of plasma without affecting that of whole-blood (SIDwb ), i.e. , the BE. We hypothesize that, during acidosis, 1) an expected plasma SID (SIDexp ) reflecting electrolytes redistribution can be predicted from albumin and hemoglobin's charges, and 2) only deviations in SID from SIDexp reflect changes in SIDwb , and therefore, BE...
February 29, 2024: Journal of Applied Physiology