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https://www.readbyqxmd.com/read/29149176/a-simple-way-for-targeted-delivery-of-an-antibiotic-in-vitro-evaluation-of-a-nanoclay-based-composite
#1
Leslie Valdés, Irela Pérez, Louis Charles de Ménorval, Ernesto Altshuler, Jon Otto Fossum, Aramis Rivera
The sodium-modified form of fluorohectorite nanoclay (NaFh) is introduced as a potential drug carrier, demonstrating its ability for the controlled release of the broad-spectrum antibiotic Ciprofloxacin through in vitro tests. The new clay-drug composite is designed to target the local infections in the large intestine, where it delivers most of the incorporated drug thanks to its pH-sensitive behavior. The composite has been conceived to avoid the use of coating technology and to decrease the side-effects commonly associated to the burst-release of the ciprofloxacin at the stomach level...
2017: PloS One
https://www.readbyqxmd.com/read/29144182/plasma-lyte-148-vs-hartmann-s-solution-for-cardiopulmonary-bypass-pump-prime-a-prospective-double-blind-randomized-trial
#2
Laurence Weinberg, Elizabeth Chiam, James Hooper, Frank Liskaser, Angela Kim Hawkins, Denise Massie, Andrew Ellis, Chong O Tan, David Story, Rinaldo Bellomo
BACKGROUND: The mechanisms of acid-base changes during cardiopulmonary bypass (CPB) remain unclear. We tested the hypothesis that, when used as CPB pump prime solutions, Plasma-Lyte 148 (PL) and Hartmann's solution (HS) have differential mechanisms of action in their contribution to acid-base changes. METHODS: We performed a prospective, double-blind, randomized trial in adult patients undergoing elective cardiac surgery with CPB. Participants received a CPB prime solution of 2000 mL, with either PL or HS...
November 1, 2017: Perfusion
https://www.readbyqxmd.com/read/29125390/responsiveness-of-voltage-gated-calcium-channels-in-sh-sy5y-human-neuroblastoma-cells-on-micropillar-substrates
#3
Wenxu Wang, Donghuo Zhong, Yu Lin, Rong Fan, Zhengjun Hou, Xiumei Cao, Yubin Ren
In this study, poly-L-lactic acid (PLLA) micropillar substrates were fabricated to evaluate the influence of topographic substrates on cell morphological and functional characteristics, such as spreading area, voltage-gated calcium channels (VGCCs) and membrane potential. The proliferation, spreading area, perimeter and circularity of SH-SY5Y cells interfaced with different substrates were first investigated. In addition, the cytoskeleton and focal adhesion of a cell as important manifestations of cell morphology were analyzed by immunofluorescence...
November 10, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29112104/cardiogenic-shock-due-to-end-stage-heart-failure-and-acute-myocardial-infarction-characteristics-and-outcome-of-temporary-mechanical-circulatory-support
#4
Hoong Sern Lim, Neil Howell
BACKGROUND: Mechanical circulatory support (MCS) is increasingly used in cardiogenic shock, but outcomes may differ between patients with acute myocardial infarction (AMI) or end-stage heart failure (ESHF). This study aimed to describe the characteristics of patients with cardiogenic shock due to AMI and ESHF. METHODS: Single centre study of consecutive patients with cardiogenic shock due to AMI (n = 26) and ESHF (n = 42) who underwent MCS (extracorporeal life support, Impella or temporary ventricular assist devices)...
November 3, 2017: Shock
https://www.readbyqxmd.com/read/29109389/overlooked-short-toxin-like-proteins-a-shortcut-to-drug-design
#5
Michal Linial, Nadav Rappoport, Dan Ofer
Short stable peptides have huge potential for novel therapies and biosimilars. Cysteine-rich short proteins are characterized by multiple disulfide bridges in a compact structure. Many of these metazoan proteins are processed, folded, and secreted as soluble stable folds. These properties are shared by both marine and terrestrial animal toxins. These stable short proteins are promising sources for new drug development. We developed ClanTox (classifier of animal toxins) to identify toxin-like proteins (TOLIPs) using machine learning models trained on a large-scale proteomic database...
October 29, 2017: Toxins
https://www.readbyqxmd.com/read/29105220/correlative-mass-spectrometry-imaging-applying-tof-sims-and-ap-maldi-to-a-single-tissue-section
#6
N Desbenoit, A Walch, B Spengler, A Brunelle, A Römpp
RATIONALE: Mass spectrometry imaging (MSI) is a powerful tool for mapping the surface of a sample. Time-of-Flight Secondary Ion Mass Spectrometry (TOF-SIMS) and Atmospheric Pressure Matrix-Assisted Laser Desorption/Ionization (AP-MALDI) offer complementary capabilities. Here, we present a workflow to apply both techniques to a single tissue section and combine the resulting data on the example of human colon cancer tissue. METHODS: Following cryo-sectioning, images were acquired using the high spatial resolution (1 μm pixel size) provided by TOF-SIMS...
November 3, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29103597/determination-of-reversed-phase-high-performance-liquid-chromatography-based-octanol-water-partition-coefficients-for-neutral-and-ionizable-compounds-methodology-evaluation
#7
Chao Liang, Jun-Qin Qiao, Hong-Zhen Lian
Reversed-phase liquid chromatography (RPLC) based octanol-water partition coefficient (logP) or distribution coefficient (logD) determination methods were revisited and assessed comprehensively. Classic isocratic and some gradient RPLC methods were conducted and evaluated for neutral, weak acid and basic compounds. Different lipophilicity indexes in logP or logD determination were discussed in detail, including the retention factor logkw corresponding to neat water as mobile phase extrapolated via linear solvent strength (LSS) model from isocratic runs and calculated with software from gradient runs, the chromatographic hydrophobicity index (CHI), apparent gradient capacity factor (kg') and gradient retention time (tg)...
October 27, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29103491/new-quaternized-cellulose-based-on-hydroxyethyl-cellulose-hec-grafted-edta-synthesis-characterization-and-application-for-pb-ii-and-cu-ii-removal
#8
Issam Jilal, Soufian El Barkany, Zahra Bahari, Ola Sundman, Abderahmane El Idrissi, Mohamed Abou-Salama, Abderrahmane Romane, Chahid Zannagui, Hassan Amhamdi
In this paper, new quaternized cellulose derivative based on Ethylenediaminetetraacetic acid (EDTA) and hydroxyethyl cellulose (HEC) is successfully prepared in homogeneous medium. The resulted product is characterized using spectroscopy techniques (FTIR, (1)H NMR and (13)C NMR). At the supramolecular level, the x-ray patterns show that a high hydrogen bond density occurs by grafting EDTA on the HEC fibers. The new adsorbent (HEC-EDTA) shows a high adsorption capacity of heavy metals (Pb (II) and Cu (II)) from aqueous metals solutions...
January 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29094140/multi-metal-dependent-nucleic-acid-enzymes
#9
REVIEW
Wenhu Zhou, Juewen Liu
Nucleic acid enzymes (NAEs) are catalytically active RNA and DNA molecules. NAEs with RNA-cleaving activity are most extensively studied for applications in analytical chemistry, gene therapy and nanotechnology. Most NAEs require metal ions for activity. From a biochemical standpoint, these NAEs are reminiscent of metalloprotein enzymes with metal binding sites. While most NAEs require a single metal for the reaction, more and more recent examples have emerged that use two or even three metals for the reaction...
November 2, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29090696/defect-free-network-formation-and-swelling-behavior-in-ionic-liquid-based-electrolytes-of-tetra-arm-polymers-synthesized-using-a-michael-addition-reaction
#10
Mari Yoshitake, Yuji Kamiyama, Kengo Nishi, Nobuko Yoshimoto, Masayuki Morita, Takamasa Sakai, Kenta Fujii
The gelation mechanism of tetra-arm poly(ethylene glycol) (TetraPEG) prepolymers via a Michael addition reaction was investigated from the viewpoint of chemical reaction kinetics. The polymer network was formed by mixing two different TetraPEGs functionalized with maleimide and thiol terminal groups (TetraPEG-MA and TetraPEG-SH) in aqueous solutions, and the gelation rate was strongly dependent on the solution pH. We found that the gelation reaction can be a second-order reaction when the acid-base equilibrium of the terminal SH groups (-SH ⇆ -S(-) + H(+)) was taken into account, resulting in a quantitative estimation of the rate constant (kgel) in the current polymer solution system...
November 1, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29076343/interfacial-connection-mechanisms-in-calcium-silicate-hydrates-polymer-nanocomposites-a-molecular-dynamics-study
#11
Yang Zhou, Dongshuai Hou, Hegoi Manzano, Carlos A Orozco, Guoqing Geng, Paulo J M Monteiro, Jiaping Liu
Properties of organic/inorganic composites can be highly dependent on the interfacial connections. In this work, molecular dynamics, using pair-potential-based force fields, was employed to investigate the structure, dynamics, and stability of interfacial connections between calcium-silicate-hydrates (C-S-H) and organic functional groups of three different polymer species. The calculation results suggest that the affinity between C-S-H and polymers is influenced by the polarity of the functional groups and the diffusivity and aggregation tendency of the polymers...
November 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29058095/potentiation-and-block-of-asic1a-by-memantine
#12
Vasiliy Y Shteinikov, Tatiana B Tikhonova, Vyacheslav S Korkosh, Denis B Tikhonov
Acid-sensing ion channels (ASICs) are modulated by various classes of ligands, including the recently described hydrophobic monoamines, which inhibit and potentiate ASICs in a subunit-specific manner. In particular, memantine inhibits ASIC1a and potentiates ASIC2a homomers. The aim of the present work was to characterize action mechanism of memantine on recombinant ASIC1a expressed in CHO (Chinese hamster ovary) cells. We have demonstrated that effect of memantine on ASIC1a strongly depends on membrane voltage, conditioning pH value and application protocol...
October 20, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/29043590/adsorption-and-desorption-for-dynamics-transport-of-hexavalent-chromium-cr-vi-in-soil-column
#13
Xiaowei Zhang, Juxiu Tong, Bill X Hu, Wenshuo Wei
Batch experiments have been carried out to study the adsorption of heavy metals in soils, and the migration and transformation of hexavalent chromium (Cr(VI)) in the soil of a vegetable base were studied by dynamic adsorption and desorption soil column experiments. The aim of this study was to investigate the effect of initial concentration and pH value on the adsorption process of Cr(VI). Breakthrough curve were used to evaluate the capacity of Cr(VI) adsorption in soil columns. The results show that the higher the initial concentration, the worse the adsorption capacity of Cr(VI)...
October 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29034950/spectroscopic-characteristics-of-rubricoccus-marinus-xenorhodopsin-rmxer-and-a-putative-model-for-its-inward-h-transport-mechanism
#14
Saki Inoue, Susumu Yoshizawa, Yu Nakajima, Keiichi Kojima, Takashi Tsukamoto, Takashi Kikukawa, Yuki Sudo
A new group of microbial rhodopsins named xenorhodopsins (XeR), which are closely related to the cyanobacterial Anabaena sensory rhodopsin, show a light-driven "inward" proton transport activity, as reported for one representative of this group from Parvularcula oceani (PoXeR). In this study, we functionally and spectroscopically characterized a new member of the XeR clade from a marine bacterium Rubricoccus marinus SG-29(T) (RmXeR). Escherichia coli cells expressing recombinant RmXeR showed a light-induced alkalization of the cell suspension, which was strongly impaired by a protonophore, suggesting that RmXeR is a light-driven "inward" proton pump as is PoXeR...
October 16, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29028294/carbon-dots-g-c3n4-nanoheterostructures-based-signal-generation-tags-for-photoelectrochemical-immunoassay-of-cancer-biomarkers-coupling-with-copper-nanoclusters
#15
Shuzhen Lv, Yi Li, Kangyao Zhang, Zhenzhen Lin, Dianping Tang
A class of 0-dimensional/2-dimensional (0D/2D) nanoheterostructures based on carbon quantum dots (CQDs) and graphitic carbon nitride (g-C3N4) was designed as the signal-generation tags for the sensitive photoelectrochemical (PEC) immunoassay of prostate-specific antigen (PSA) coupling with the copper nanoclusters (CuNCs). Combination of CQDs with g-C3N4 promoted the photoexcited electron/hole separation and largely increased the photocurrents of the nanoheterostructures. Initially, a sandwich-type immunoreaction was carried out on monoclonal anti-PSA antibody-coated microplate by using PSA aptamer linked with CuNCs as the tracer...
November 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29024100/an-all-integrated-anode-via-interlinked-chemical-bonding-between-double-shelled-yolk-structured-silicon-and-binder-for-lithium-ion-batteries
#16
Yajie Liu, Zhixin Tai, Tengfei Zhou, Vitor Sencadas, Jian Zhang, Lei Zhang, Konstantin Konstantinov, Zaiping Guo, Hua Kun Liu
The concept of an all-integrated design with multifunctionalization is widely employed in optoelectronic devices, sensors, resonator systems, and microfluidic devices, resulting in benefits for many ongoing research projects. Here, maintaining structural/electrode stability against large volume change by means of an all-integrated design is realized for silicon anodes. An all-integrated silicon anode is achieved via multicomponent interlinking among carbon@void@silica@silicon (CVSS) nanospheres and cross-linked carboxymethyl cellulose and citric acid polymer binder (c-CMC-CA)...
October 12, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28989810/carbon-support-surface-effects-in-the-gold-catalyzed-oxidation-of-5-hydroxymethylfurfural
#17
Baira Donoeva, Nazila Masoud, Petra E de Jongh
Oxidation of 5-hydroxymethylfurfural into 2,5-furandicarboxylic acid is an important transformation for the production of bio-based polymers. Carbon-supported gold catalysts hold great promise for this transformation. Here we demonstrate that the activity, selectivity, and stability of the carbon-supported gold nanoparticles in the oxidation of 5-hydroxymethylfurfural strongly depend on the surface properties of the carbon support. Gold nanoparticles supported on basic carbon materials with a low density of functional groups demonstrate higher activity in 5-hydroxymethylfurfural oxidation (TOFAu up to 1195 h(-1)), higher selectivity to 2,5-furandicarboxylic acid, and better stability in comparison to gold nanoparticles supported on carbon materials with acidic surface groups...
July 7, 2017: ACS Catalysis
https://www.readbyqxmd.com/read/28978326/tracking-of-pigment-accumulation-and-secretion-in-extractive-fermentation-of-monascus-anka-gim-3-592
#18
Gong Chen, Qi Bei, Tao Huang, Zhenqiang Wu
BACKGROUND: Monascus pigments are promising sources for food and medicine due to their natural food-coloring functions and pharmaceutical values. The innovative technology of extractive fermentation is used to promote pigment productivity, but reports of pigment trans-membrane secretion mechanism are rare. In this study, tracking of pigment accumulation and secretion in extractive fermentation of Monascus anka GIM 3.592 was investigated. RESULTS: The increased vacuole size in mycelia correlated with fluorescence intensity (r > 0...
October 4, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28975058/effect-of-the-environment-on-horizontal-gene-transfer-between-bacteria-and-archaea
#19
Clara A Fuchsman, Roy Eric Collins, Gabrielle Rocap, William J Brazelton
BACKGROUND: Horizontal gene transfer, the transfer and incorporation of genetic material between different species of organisms, has an important but poorly quantified role in the adaptation of microbes to their environment. Previous work has shown that genome size and the number of horizontally transferred genes are strongly correlated. Here we consider how genome size confuses the quantification of horizontal gene transfer because the number of genes an organism accumulates over time depends on its evolutionary history and ecological context (e...
2017: PeerJ
https://www.readbyqxmd.com/read/28973475/influence-of-nucleotide-modifications-at-the-c2-position-on-the-hoogsteen-base-paired-parallel-stranded-duplex-of-poly-a-rna
#20
William Copp, Alexey Y Denisov, Jingwei Xie, Anne M Noronha, Christopher Liczner, Nozhat Safaee, Christopher J Wilds, Kalle Gehring
Polyadenylate (poly(A)) has the ability to form a parallel duplex with Hoogsteen adenine:adenine base pairs at low pH or in the presence of ammonium ions. In order to evaluate the potential of this structural motif for nucleic acid-based nanodevices, we characterized the effects on duplex stability of substitutions of the ribose sugar with 2'-deoxyribose, 2'-O-methyl-ribose, 2'-deoxy-2'-fluoro-ribose, arabinose and 2'-deoxy-2'-fluoro-arabinose. Deoxyribose substitutions destabilized the poly(A) duplex both at low pH and in the presence of ammonium ions: no duplex formation could be detected with poly(A) DNA oligomers...
September 29, 2017: Nucleic Acids Research
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