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Gas agents

Dingdong Zhang, ChuHyun Bae, Junghak Lee, Jiho Lee, Zeyu Jin, Myeongmo Kang, Young Suk Cho, Jeong-Han Kim, Weontae Lee, Sung-Kil Lim
Irisin, a recently identified hormone secreted by skeletal muscle in response to exercise, exhibits anabolic effects on the skeleton primarily through the stimulation of bone formation. However, the mechanism underlying the irisin-stimulated anabolic response remains largely unknown. To uncover the underlying mechanism, we biosynthesized recombinant irisin (r-irisin) using an Escherichia coli expression system and used it to treat several osteoblast cell types. Our synthesized r-irisin could promote proliferation and differentiation of osteoblasts as evidenced by enhanced expression of osteoblast-specific transcriptional factors, including Runt-related transcription factor-2 (Runx2), Oster (Osx), as well as early osteoblastic differentiation markers such as alkaline phosphatase (Alp) and collagen type I alpha 1 (Col1a1)...
May 15, 2018: Bone
Ning Wang, Lin Chen, Mingsen Li, Naizhong Jin, Bo Wei
OBJECTIVE: To investigate the risk factors of prolonged postoperative ileus (PPOI) after gastric cancer surgery. METHODS: Definition of PPOI was that gastrointestinal function did not return to normal within 96 hours after operation. Diagnostic criteria of PPOI were as follows: according with over 2 below conditions at postoperative 97-hour: (1) moderate to severe sick (mild: 1-3 points, moderate: 4-7 points, severe: 8-10 points) or vomiting occurred in past 12 hours...
May 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
Giantommaso Scarascia, Scott A Yap, Anna H Kaksonen, Pei-Ying Hong
Pseudomonas aeruginosa is a ubiquitous member of marine biofilm, and reduces thiosulfate to produce toxic hydrogen sulfide gas. In this study, lytic bacteriophages were isolated and applied to inhibit the growth of P. aeruginosa in planktonic mode at different temperature, pH, and salinity. Bacteriophages showed optimal infectivity at a multiplicity of infection of 10 in saline conditions, and demonstrated lytic abilities over all tested temperature (25, 30, 37, and 45°C) and pH 6-9. Planktonic P. aeruginosa exhibited significantly longer lag phase and lower specific growth rates upon exposure to bacteriophages...
2018: Frontiers in Microbiology
Yu Jinsui, Situ Bing, Luo Muhua, Li Yue, Liao Jianyi, Du Meng, Cai Kuan, Yang Chaopin, Zhang Hui, Chen Zhiyi
INTRODUCTION: Although a great many strategies have been proposed for tumor-targeted chemotherapy, current delivery methods of anticancer drugs present limited success with inevitable systemic toxicity. The aim of this study was to develop a new kind of theranostic carrier for targeted tumor therapy. METHODS: Prior to prepare CHC-PFP-DOX, carboxymethyl-hexanoyl chitosan (CHC) was synthesized by acylation of carboxymethyl chitosan. To develop CHC-PFP, perfluoropentane (PFP), an ultrasound gas precursor, were simultaneously encapsulated into the hydrophobic inner cores of pre-formulated CHC micelle in aqueous phase via using the oil in water (O/W) emulsion method...
May 15, 2018: Current Pharmaceutical Design
Navita Sinha, Timothy A Kral
Methanogens have been considered models for life on Mars for many years. In order to survive any exposure at the surface of Mars, methanogens would have to endure Martian UVC radiation. In this research, we irradiated hydrated and desiccated cultures of slightly halophilic Methanococcus maripaludis and non-halophilic Methanobacterium formicicum for various time intervals with UVC (254 nm) radiation. The survivability of the methanogens was determined by measuring methane concentrations in the headspace gas samples of culture tubes after re-inoculation of the methanogens into their growth-supporting media following exposure to UVC radiation...
May 12, 2018: Microorganisms
Koki Maeda, Fumihito Miyatake, Ryoki Asano, Kei-Ichi Nakajima, Takeki Maeda, Kazunori Iwabuchi
Animal manure is a source of the greenhouse gas nitrous oxide (N2 O), therefore understanding the mechanisms underlying its production is essential for developing mitigating strategies and sustainable livestock production system. In this study, microbial communities potentially involved in multiple emission peaks during initial stage of laboratory-scale dairy manure composting with forced aeration system were investigated. Mature compost was used for the bulking agent. Change of overall bacterial community and nitrification-denitrification gene abundance were monitored by using 16S rRNA gene amoA, nirS, nirK or nosZ genes, respectively...
April 30, 2018: Chemosphere
Carlos A Valdez, Mira K Marchioretto, Roald N Leif, Saphon Hok
Trimethyloxonium tetrafluoroborate (TMO·BF4 ) has been used in the simultaneous derivatization of phosphonic and 2-aminoethylsulfonic acids related to nerve agents in different soils for their enhanced detection and identification by electron ionization gas chromatography-mass spectrometry (EI-GC-MS). The panel of acids consisted of five Schedule 2 phosphonic acids (methyl methylphosphonic acid, ethyl methylphosphonic acid, isopropyl methylphosphonic acid, pinacolyl methylphosphonic acid and cyclohexyl methylphosphonic acid) along with two sulfonic acids, N,N-diethyl-2-aminoethylsulfonic acid and N,N-diisopropyl-2-aminoethylsulfonic acid...
April 27, 2018: Forensic Science International
Ran Wei, Xiaoqun Wang, Xu Zhang, Chen Chen, Shanyi Du
To solve the drawbacks of poor dispersion and weak interface in gas barrier nanocomposites, a novel epoxy-diamine adduct (DDA) was synthesized by reacting epoxy monomer DGEBA with curing agent D400 to functionalize montmorillonite (MMT), which could provide complete compatibility and reactivity with a DGEBA/D400 epoxy matrix. Thereafter, sodium type montmorillonite (Na-MMT) and organic-MMTs functionalized by DDA and polyether amines were incorporated with epoxy to manufacture nanocomposites. The effects of MMT functionalization on the morphology and gas barrier property of nanocomposites were evaluated...
May 3, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Xiaoyong Qiang, Ming Hu, Boshuo Zhao, Yue Qin, Ran Yang, Liwei Zhou, Yuxiang Qin
The decoration of noble metal nanoparticles (NPs) on the surface of metal oxide semiconductors to enhance material characteristics and gas-sensing performance has recently attracted increasing attention from researchers worldwide. Here, we have synthesized porous silicon (PS)/WO₃ nanorods (NRs) functionalized with Pd NPs to enhance NO₂ gas-sensing performance. PS was first prepared using electrochemical methods and worked as a substrate. WO₃ NRs were synthesized by thermally oxidizing W film on the PS substrate...
May 10, 2018: Materials
En-Jie Wang, Zhu-Yin Sui, Ya-Nan Sun, Zhuang Ma, Bao-Hang Han
In this work, a series of highly porous sulfur-doped carbons are prepared through physical activation methods by using polythiophene as a precursor. The morphology, structure, and physichochemical properties are revealed by a variety of characterization methods, such as scanning electron microscopy, Raman spectroscopy, X-ray photoelectron spectroscopy, and nitrogen sorption measurement. Their porosity parameters and chemical compositions can be well-tuned by changing the activating agents (steam and carbon dioxide) and reaction temperature...
May 11, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Seong In Chi
The first clinical application of nitrous oxide (N2 O) was in 1844, by an American dentist named Horace Wells who used it to control pain during tooth extraction. Since then, N2 O has shared a 170-year history with modern dental anesthesia. N2 O, an odorless and colorless gas, is very appealing as a sedative owing to its anxiolytic, analgesic, and amnestic properties, rapid onset and recovery, and, in particular, needle-free application. Numerous studies have reported that N2 O can be used safely and effectively as a procedural sedation and analgesia (PSA) agent...
April 2018: Journal of Dental Anesthesia and Pain Medicine
Joycy Francely Sampaio Dos Santos, Janaína Esmeraldo Rocha, Camila Fonseca Bezerra, Maria Karollyna do Nascimento Silva, Yedda Maria Lobo Soares de Matos, Thiago Sampaio de Freitas, Antonia Thassya Lucas Dos Santos, Rafael Pereira da Cruz, Antonio Júdson Targino Machado, Tigressa Helena Soares Rodrigues, Edy Sousa de Brito, Dédora Lima Sales, Waltécio de Oliveira Almeida, José Galberto Martins da Costa, Henrique Douglas Melo Coutinho, Maria Flaviana Bezerra Morais-Braga
The development of fungal resistance to antifungal drugs has been worsening over the years and as a result research on new antifungal agents derived from plants has intensified. Eugenia uniflora L. (pitanga) has been studied for its various biological actions. In this study the chemical composition and antifungal effects of the E. uniflora essential oil (EULEO) were investigated against Candida albicans (CA), Candida krusei (CK) and Candida tropicalis (CT) standard strains. The essential oil obtained through hydro-distillation was analyzed by gas chromatography coupled to mass spectrometry (GC-MS)...
September 30, 2018: Food Chemistry
Samir A Anuj, Harsukh P Gajera, Darshna G Hirpara, Baljibhai A Golakiya
With the threat of the growing number of bacteria resistant to antibiotics, the re-emergence of previously deadly infections and the emergence of new infections, there is an urgent need for novel therapeutic agent. Silver in the nano form, which is being used increasingly as antibacterial agents, may extend its antibacterial application to emerging and re-emerging multidrug-resistant pathogens, the main cause of nosocomial diseases worldwide. In the present study, a completely bottom up method to prepare green nano-silver was used...
April 24, 2018: Journal of Trace Elements in Medicine and Biology
Wen-Dong Wang, Nan-Nan Zhang, Warren Chanda, Min Liu, Syed Riaz Ud Din, Yun-Peng Diao, Lei Liu, Jing Cao, Xiao-Li Wang, Xing-Yun Li, An-Hong Ning, Min Huang, Min-Tao Zhong
The aim of this study is to assess the antibacterial and anti-biofilm properties of the lipid extract from Mantidis ootheca against the gentamycin resistant Pseudomonas aeruginosa. The chemical composition of the lipid extract and its relative proportion were determined using the technique of gas chromatography coupled with mass spectrometry (GC-MS). Antibacterial susceptibility tests were performed using a disc diffusion assay and the minimum inhibition concentration (MIC) was determined by way of the agar dilution method...
May 2018: Journal of Zhejiang University. Science. B
Qian-Ming Qi, Yin-Cun Xue, Jian Lv, Di Sun, Jian-Xin Du, Sheng-Qiang Cai, Yun-He Li, Tian-Cun Gu, Mu-Bing Wang
Ginkgolic acids may induce malignant cell death via the B-cell lymphoma 2 (Bcl-2)-associated X protein (Bax)/Bcl-2 apoptosis pathway. Concurrently, apoptosis, autophagy and mitochondrial dysfunction may also be involved in bringing about this endpoint. The anticancer effect of Ginkgolic acids (GAs) was investigated using the HepG2 cell line. The median lethal dose of the GAs of the HepG2 was measured via an MTT assay, the dose-response curves were evaluated and changes in cell morphology were monitored by microscopy...
May 2018: Oncology Letters
Andrea F G Gargano, Liana S Roca, Ryan T Fellers, Max Bocxe, Elena Domínguez Vega, Govert Willem Somsen
Recent progress in top-down proteomics has driven the demand for chromatographic methods compatible with mass spectrometry (MS) that can separate intact proteins. Hydrophilic interaction liquid chromatography (HILIC) on amide stationary phases has recently shown good potential for the characterization of glycoforms of intact proteins. In the present study, we demonstrate that HILIC can separate a wide range of proteins exhibiting orthogonal selectivity with respect to reversed-phase LC (RPLC). However, the application of HILIC to the analysis of low abundance proteins (as e...
May 3, 2018: Analytical Chemistry
Bing Han, Qinghai Li, Zhen Liu, Zhongchao Tan, Yanguo Zhang
An experimental investigation of operational parameters, including liquid/gas ratio (L/G), inlet nitric oxide (NO) concentration, reaction temperature, and pH value of absorbing agent, on NO removal efficiency with hexamminecobalt(II) solution scrubbing was conducted on a pilot-scale facility to search optimal operation conditions. The experimental results show that NO removal efficiency increased with the pH value of hexamminecobalt solution, while the improving rate dropped gradually. When the reaction temperature increased, the NO removal efficiency increased first and then decreased...
May 1, 2018: Waste Management & Research
Dina Sameh Soliman, Mohamed Yassin
Methemoglobinemia is a rare overlooked differential diagnosis in patients presented with cyanosis and dyspnea unrelated to cardiopulmonary causes. Our patient is 29 year old Indian non-smoker male, his story started 6 months prior to presentation to our center when he had generalized fatigue and discoloration of hands. He presented with persistent polycythemia with elevated hemoglobin level. The patient was misdiagnosed in another center as polycythemia and treated with Imatinib. The diagnosis of PV was revisited and ruled out in view of negative JAK2, normal erythropoietin level and absence of features of panmyelosis...
March 2, 2018: Hematology Reports
Preeti Rawat, Anil Kumar, Tryambak Deo Singh, Mahesh Pal
Background: Streblus asper , family Moraceae is well-known important medicinal plant used in the Indian system of medicine. In Ayurveda, stem bark of S. asper is recommended against elephantiasis for which there is still no any other effective medicine in the modern system of medicine. Objectives: In the present work, methanol extract (SAM) and its fractions of S. asper leave tested for in vitro anticancer activity against cancer cell lines (MCF-7, A-549, Hep-G2, and K-562) which claims its folklore importance in cancer and gas chromatography-mass spectrometry identification of extracts was also performed...
April 2018: Pharmacognosy Magazine
Jason E Ham, Paul Siegel, Howard Maibach
Formaldehyde allergic contact dermatitis (ACD) may be due to products with free formaldehyde or formaldehyde-releasing agents, however, assessment of formaldehyde levels in such products is infrequently conducted. The present study quantifies total releasable formaldehyde from "in-use" products associated with formaldehyde ACD and tests the utility of commercially available formaldehyde spot test kits. Personal care products from 2 patients with ACD to formaldehyde were initially screened at the clinic for formaldehyde using a formaldehyde spot test kit...
May 3, 2018: Cutaneous and Ocular Toxicology
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