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https://www.readbyqxmd.com/read/28436705/pharmacologically-increasing-collateral-perfusion-during-acute-stroke-using-a-carboxyhemoglobin-gas-transfer-agent-sanguinate%C3%A2-in-spontaneously-hypertensive-rats
#1
Marilyn J Cipolla, Italo Linfante, Abe Abuchowski, Ronald Jubin, Siu-Lung Chan
Similar to patients with chronic hypertension, spontaneously hypertensive rats (SHR) develop fast core progression during middle cerebral artery occlusion (MCAO) resulting in large final infarct volumes. We investigated the effect of Sanguinate™ (SG), a PEGylated carboxyhemoglobin (COHb) gas transfer agent, on changes in collateral and reperfusion cerebral blood flow and brain injury in SHR during 2 h of MCAO. SG (8 mL/kg) or vehicle ( n = 6-8/group) was infused i.v. after 30 or 90 min of ischemia with 2 h reperfusion...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28434709/target-analysis-of-tert-butyldimethylsilyl-derivatives-of-nerve-agent-hydrolysis-products-by-selectable-one-dimensional-or-two-dimensional-gas-chromatography-mass-spectrometry
#2
Yasuo Seto, Masumi Tachikawa, Mieko Kanamori-Kataoka, Kikuo Sasamoto, Nobuo Ochiai
A target analysis method for the sensitive and discriminative determination of the nerve agent hydrolysis products alkyl methylphosphonic acids as their tert-butyldimethylsilyl (TBDMS) derivatives was developed using a combination of selectable one- and two-dimensional ((1)D/(2)D) GC-MS, and applied to the analysis of samples with significant interfering matrices. After sample drying, the alkylmethylphosphonic acids and methylphosphonic acid (MPA) were converted to TBDMS derivatives by addition of N-methyl-N-(tert-butyldimethylsilyl)trifluoroacetamide with heating, and subjected to (1)D/(2)D GC-MS...
April 13, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28431330/gas-forming-liposomes-prepared-using-a-liposomal-magnetoporation-method
#3
Jae Min Lee, Dong Sup Kwag, Yu Seok Youn, Eun Seong Lee
In this study, we report a gas-forming drug carrier engineered using the liposomal magnetoporation method. The liposomes that were magnetoporated under a magnetic shear stress possessed an opened lipid bilayer hole. A photosensitizing model drug (chlorin e6: Ce6) and 1H-1H-2H-perfluoro-1-hexene (PFH, as a volatile gas-forming agent) were efficiently loaded into the opened holes of the magnetoporated liposomes. PFH in the liposomes is vaporized at 50°C and can initiate liposome destabilization. The experimental results demonstrated that the liposomes were destabilized at 50°C efficiently released Ce6 and enhanced Ce6-mediated phototoxicity against KB tumor cells...
April 12, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28429165/the-use-of-rapid-test-quikread-go%C3%A2-strep-a-in-bacterial-pharyngotonsillitis-diagnosing-and-therapeutic-decisions
#4
E Stefaniuk, K Bosacka, M Wanke-Rytt, W Hryniewicz
Group A Streptococci (GAS) are the main causative agents of bacterial pharyngitis, which require antibiotic therapy. Rapid diagnostic tests detecting GAS combined with Centor/McIsaac score enable accurate differential diagnosis (viral vs. bacterial) and prompt commencement of targeted treatment. The aim of this study was to assess the specificity, sensitivity, PPV and NPV of QuikRead go® Strep A (Orion Diagnostica Oy, Finland) recommended for the detection of GAS in pharyngeal swabs. Quick diagnostic test results were compared with physical examination findings, Centor/McIsaac score and results of reference testing (conventional microbial cultures)...
April 21, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28420101/the-effect-of-citrus-essential-oils-and-their-constituents-on-growth-of-xanthomonas-citri-subsp-citri
#5
Hossein Mirzaei-Najafgholi, Saeed Tarighi, Morteza Golmohammadi, Parissa Taheri
Citrus bacterial canker (CBC) caused by Xanthomonas citri subsp. citri (Xcc), is the most devastating of the citrus diseases worldwide. During our study, we found that Essential oils (EOs) of some citrus cultivars are effective on Xcc. Therefore, it prompted us to determine the plant metabolites responsible for the antibacterial properties. We obtained EOs from some locally cultivated citrus by using a Clevenger apparatus and their major constituents were identified by gas chromatography/mass spectrometry (GC-MS)...
April 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28418785/metabolomics-analysis-of-the-osteogenic-differentiation-of-umbilical-cord-blood-mesenchymal-stem-cells-reveals-differential-sensitivity-to-osteogenic-agents
#6
Michail E Klontzas, Spyros I Vernardis, Manolis Heliotis, Eleftherios Tsiridis, Athanasios Mantalaris
Mesenchymal stem cells (MSCs) of fetal origin, such as umbilical cord blood MSCs (UCB MSCs), have emerged as a promising cell source for musculoskeletal tissue regeneration because of their higher proliferation potential, lack of donor site morbidity, and their off-the-shelf potential. MSCs differentiated toward the osteogenic lineage exhibit a specific metabolic phenotype characterized by reliance to oxidative phosphorylation for energy production and reduced glycolytic rates. Currently, limited information exists on the metabolic transitions at different stages of the osteogenic process after osteoinduction with different agents...
April 18, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/28418689/an-official-american-thoracic-society-workshop-report-chemical-inhalational-disasters-biology-of-lung-injury-development-of-novel-therapeutics-and-medical-preparedness
#7
Eleanor M Summerhill, Gary W Hoyle, Sven-Eric Jordt, Bronwen J Jugg, James G Martin, Sadis Matalon, Steven E Patterson, David J Prezant, Alfred M Sciuto, Erik R Svendsen, Carl W White, Livia A Veress
This report is based upon the proceedings from the Inhalational Lung Injury Workshop jointly sponsored by the American Thoracic Society (ATS) and the National Institute of Health (NIH)/National Institute of Neurologic Disorders and Stroke (NINDS) Countermeasures Against Chemical Threats (CounterACT) program on May 21, 2013 in Philadelphia, PA. The CounterACT program facilitates research leading to the development of new and improved medical countermeasures for chemical threat agents. The workshop was initiated by the Terrorism and Inhalational Disasters (TID) Section of the Environmental, Occupational, and Population Health Assembly (EOPH) of the ATS...
April 18, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28418289/volatile-organic-compounds-produced-by-a-soil-isolate-bacillus-subtilis-fa26-induce-adverse-ultra-structural-changes-to-the-cells-of-clavibacter-michiganensis-ssp-sepedonicus-the-causal-agent-of-bacterial-ring-rot-of-potato
#8
Faheem Uddin Rajer, Huijun Wu, Yongli Xie, Shanshan Xie, Waseem Raza, Hafiz Abdul Samad Tahir, Xuewen Gao
Rhizobacterial volatile organic compounds (VOCs) play an important role in the suppression of soil-borne phytopathogens. In this study, the VOCs produced by a soil-isolate, Bacillus subtilis FA26, were evaluated in vitro for their antibacterial activity against Clavibacter michiganensis ssp. sepedonicus (Cms), the causal agent of bacterial ring rot of potato. The VOCs emitted by FA26 inhibited the growth of Cms significantly compared with the control. Scanning and transmission electron microscopy analyses revealed distorted colony morphology and a wide range of abnormalities in Cms cells exposed to the VOCs of FA26...
April 18, 2017: Microbiology
https://www.readbyqxmd.com/read/28417577/metal-hydride-nanoparticles-with-ultrahigh-structural-stability-and-hydrogen-storage-activity-derived-from-microencapsulated-nanoconfinement
#9
Jiguang Zhang, Yunfeng Zhu, Huaijun Lin, Yana Liu, Yao Zhang, Shenyang Li, Zhongliang Ma, Liquan Li
Metal hydrides (MHs) have recently been designed for hydrogen sensors, switchable mirrors, rechargeable batteries, and other energy-storage and conversion-related applications. The demands of MHs, particular fast hydrogen absorption/desorption kinetics, have brought their sizes to nanoscale. However, the nanostructured MHs generally suffer from surface passivation and low aggregation-resisting structural stability upon absorption/desorption. This study reports a novel strategy named microencapsulated nanoconfinement to realize local synthesis of nano-MHs, which possess ultrahigh structural stability and superior desorption kinetics...
April 18, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28415001/degradation-of-synthetic-fragrances-by-laccase-mediated-system
#10
Laura Vallecillos, Yumna Sadef, Francesc Borrull, Eva Pocurull, Kai Bester
Laccase mediator systems are important biodegradation agents as the rate of reaction could be enhanced in the presence of redox mediators. In the present study the commercial enzyme laccase from Trametes versicolor and the redox mediator 2,2'-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) were used for the biotransformation of the synthetic fragrances 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8,-tetramethyl-2-naphthyl)ethan-1-one (Iso-E-Super, OTNE), 1,3,4,6,7,8,-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-[g]-2-benzopyran (Galaxolide, HHCB), 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphtalene (Tonalide, AHTN) and the transformation product of HHCB, 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-[g]-2-benzopyran-1-one (Galaxolidone, HHCB-lactone) in water...
April 4, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28414143/the-use-of-hemoglobin-vesicles-for-delivering-medicinal-gas-for-the-treatment-of-intractable-disorders
#11
REVIEW
Kazuaki Taguchi, Keishi Yamasaki, Hiromi Sakai, Toru Maruyama, Masaki Otagiri
Bioactive gaseous molecules, such as oxygen (O2) and carbon monoxide (CO), are essential elements for most living organisms to maintain their homeostasis and biological activities. An accumulating body of evidence suggests that such molecules can be used in clinics as a medical gas in the treatment of various intractable disorders. Recent developments in hemoglobin-encapsulated liposomes, namely, Hemoglobin-vesicles (HbV), possess great potential for retaining O2 and CO, and could lead to strategies for the development of novel pharmacological agents as medical gas donors...
April 13, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28413127/evolution-of-circulating-tumor-dna-profile-from-first-line-to-subsequent-therapy-in-metastatic-renal-cell-carcinoma
#12
Sumanta K Pal, Guru Sonpavde, Neeraj Agarwal, Nicholas J Vogelzang, Sandy Srinivas, Naomi B Haas, Sabina Signoretti, Bradley A McGregor, Jeremy Jones, Richard B Lanman, Kimberly C Banks, Toni K Choueiri
BACKGROUND: Treatment of metastatic renal cell carcinoma (mRCC) typically entails mechanistically distinct agents across the first- and second-line setting. Activity of these agents may be predicated on selective pressure that modulates RCC biology. Circulating tumor DNA (ctDNA) is a platform to noninvasively ascertain temporal changes in genomic profile. OBJECTIVE: To assess the ctDNA profile in a large cohort of mRCC patients, and to assess changes across patients receiving first-line and later lines of therapy...
April 13, 2017: European Urology
https://www.readbyqxmd.com/read/28410484/microalgae-screening-under-co2-stress-growth-and-micro-nutrients-removal-efficiency
#13
Fida Hussain, Syed Zahir Shah, Wenguang Zhou, Munawar Iqbal
Algae are one of the promising agents for greenhouse gas reduction and biofuel production. Different technologies have been developed and introduced in last decades for algae growth. Algae plays a very imperative role in the aquatic ecosystem regarding CO2 reduction and micro-nutrient removal. In present investigation, eight locally isolated (microalgae) strains and two pure strains were studied. The selected microalgae were grown under variable CO2 concentration and CO2 biofixation efficiencies along with micro-nutrient removal were monitored...
March 30, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28405940/assessing-the-interplay-between-the-physicochemical-parameters-of-ion-pairing-reagents-and-the-analyte-sequence-on-the-electrospray-desorption-process-for-oligonucleotides
#14
Babak Basiri, Mandi M Murph, Michael G Bartlett
Alkylamines are widely used as ion-pairing agents during LC-MS of oligonucleotides. In addition to a better chromatographic separation, they also assist with the desorption of oligonucleotide ions into the gas phase, cause charge state reduction, and decrease cation adduction. However, the choice of such ion-pairing agents has considerable influence on the MS signal intensity of oligonucleotides as they can also cause significant ion suppression. Interestingly, optimal ion-pairing agents should be selected on a case by case basis as their choice is strongly influenced by the sequence of the oligonucleotide under investigation...
April 12, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28402665/kinetic-modeling-of-the-thermal-destruction-of-nitrogen-mustard-gas
#15
Juan-Carlos Lizardo-Huerta, Baptiste Sirjean, Laurent Verdier, René Fournet, Pierre-Alexandre Glaude
The destruction of stockpiles or unexploded ammunitions of nitrogen mustard (tris(2-chloroethyl)amine, HN-3) requires the development of safe processes. The thermal destruction of this kind of compound is one of the most efficient method of destruction. Because of the high-level of toxicity of this chemical, there is a considerable lack of knowledge on the chemical kinetics at high temperatures. In this study, a detailed chemical kinetic model for the pyrolysis of nitrogen mustard gas is developed based on a large number of thermokinetic parameters calculated with theoretical chemistry...
April 20, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28393940/directed-adenine-functionalization-for-creating-complex-architectures-for-material-and-biological-applications
#16
Balaram Mohapatra, Pratibha, Sandeep Verma
In this feature article, targeted design strategies are outlined for modified adenine nucleobase derivatives in order to construct metal-mediated discrete complexes, ring-expanded purine skeletons, linear and catenated coordination polymers, shape-selective MOFs, and purine-capped nanoparticles, with a wide range of applications from gas and solvent adsorption to bioimaging agents and anticancer metallodrugs. The success of such design strategies could be ascribed to the rich chemistry of purine and pyrimidine derivatives, versatile coordination behavior, ability to bind a host of metal ions, which could be further tuned by the introduction of additional functionalities, and their inherent propensity to hydrogen bond and exhibit π-π interactions...
April 10, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28392780/biocontrol-potentials-of-antimicrobial-peptide-producing-bacillus-species-multifaceted-antagonists-for-the-management-of-stem-rot-of-carnation-caused-by-sclerotinia-sclerotiorum
#17
S Vinodkumar, S Nakkeeran, P Renukadevi, V G Malathi
Bacillus species are widely exploited as biocontrol agents because of their efficiency in impeding various plant pathogens with multifaceted approach. In this study, Bacillus species were isolated from rhizosphere of various plants viz., carnations, cotton, turmeric, and bananas in Tamil Nadu state of India. Their potential to control the mycelial growth of Sclerotinia sclerotiorum was assessed in vitro by dual plate and partition plate techniques. B. amyloliquefaciens strain VB7 was much effective in inhibiting mycelial growth (45% inhibition of over control) and sclerotial production (100%)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28391680/stoichiometry-morphology-and-size-controlled-electrochemical-fabrication-of-cuxo-x-1-2-at-underpotential
#18
Cemile Kartal, Yeşim Hanedar, Tuba Öznülüer, Ümit Demir
A new one-step electrochemical approach has been developed for the morphology, size, and stoichiometry-controlled synthesis of Cu2O, CuO, and Cu2O/CuO composite structures at room temperature without using surfactants, capping agents, or any other additives. The electrochemical deposition of a Cu monolayer using underpotential deposition (UPD) and the flow rate of oxygen gas bubbled through the deposition solution used for oxidation of the Cu layer are the key parameters for controlling the stoichiometry of the CuxO (x = 1, 2) structures...
April 14, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28391597/contrast-enhanced-ultrasound-imaging-in-vivo-with-laser-activated-nanodroplets
#19
Heechul Yoon, Steven K Yarmoska, Alexander S Hannah, Changhan Yoon, Kristina A Hallam, Stanislav Y Emelianov
PURPOSE: This study introduces a real-time contrast-enhanced ultrasound imaging method with recently developed laser-activated nanodroplets (LANDs), a new class of phase-change nanometer-scale contrast agents that provides perceptible, sustained high-contrast with ultrasound. METHODS: In response to pulsed laser irradiation, the LANDs-, which contain liquid perfluorohexane and optical fuses-blink (vaporize and recondense). That is, they change their state from liquid nanodroplets to gas microbubbles, and then back to liquid nanodroplets...
April 9, 2017: Medical Physics
https://www.readbyqxmd.com/read/28390999/measuring-nitrate-reductase-activity-from-human-and-rodent-tongues
#20
Khandaker A Ahmed, Alexandria L Nichols, Jaideep Honavar, Mark T Dransfield, Sadis Matalon, Rakesh P Patel
Reduction of salivary nitrate to nitrite by oral microbes expressing nitrate-reductase has emerged as a crucial pathway in systemic NO homeostasis in humans and other mammals. Selective depletion of oral microbes prevents dietary nitrate-dependent lowering of blood pressure, inhibition of platelet aggregation and ischemic injury. To date, most studies interrogate enterosalivary nitrate reduction by following changes in saliva or plasma nitrite and NO-signaling (functional) end points. Little is known about whether, and if so how, nitrate-reductase enzymatic activity per se (i...
June 1, 2017: Nitric Oxide: Biology and Chemistry
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