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https://www.readbyqxmd.com/read/28340370/validation-of-comet-assay-in-oregon-r-and-wild-type-strains-of-drosophila-melanogaster-exposed-to-a-natural-radioactive-environment-in-brazilian-semiarid-region
#1
Cícero Jorge Verçosa, Aroldo Vieira de Moraes Filho, Ícaro Fillipe de Araújo Castro, Robson Gomes Dos Santos, Kenya Silva Cunha, Daniela de Melo E Silva, Ana Cristina Lauer Garcia, Julio Alejandro Navoni, Viviane Souza do Amaral, Claudia Rohde
Natural radiation of geological origin is a common phenomenon in Brazil, a country where radioactive agents such as uranium may be often found. As an unstable atom, uranium undergoes radioactive decay with the generation of a series of decay by-products, including radon, which may be highly genotoxic and trigger several pathological processes, among which cancer. Because it is a gas, radon may move freely between cracks and gaps in the ground, seeping upwards into the buildings and in the environment. In this study, two Drosophila melanogaster Meigen (Diptera, Drosophilidae) strains called Oregon-R and Wild (collected in a non-radioactive environment) were exposed to atmospheric radiation in the Lajes Pintadas city, in the semiarid zone of northeastern Brazil...
March 21, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28338319/postmetalated-zirconium-metal-organic-frameworks-as-a-highly-potent-bactericide
#2
Boushra Mortada, Tamara Abou Matar, Aya Sakaya, Hala Atallah, Zeinab Kara Ali, Pierre Karam, Mohamad Hmadeh
Metal-organic frameworks (MOFs) have emerged as an important class of hybrid organic-inorganic materials. One of the reasons they have gained remarkable attention is attributed to the possibility of altering them by postsynthetic modification, thereby providing access to new and novel advanced materials. MOFs have been applied in catalysis, gas storage, gas separation, chemical sensing, and drug delivery. However, their bactericidal use has rarely been explored. Herein, we developed a two-step process for the synthesis of zirconium-based MOFs metalated with silver cations as a potent antibacterial agent...
March 24, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28338071/phase-transition-nanodroplets-for-real-time-photoacoustic-ultrasound-dual-modality-imaging-and-photothermal-therapy-of-sentinel-lymph-node-in-breast-cancer
#3
Lu Yang, Juan Cheng, Yuli Chen, Shengjie Yu, Fengqiu Liu, Yang Sun, Yu Chen, Haitao Ran
Pathological status of lymph nodes (LNs) plays a critical role in staging and treatment for the patients with breast cancer. Sentinel lymph node biopsy has become the standard method in determining pathological status of axillary LNs. Therefore, the determination of sentinel lymph nodes (SLNs) and therapy of metastatic LNs are highly desirable in clinic. Herein, an unprecedented carbon nanoparticles (CNs)-incorporated liquid-gas phase-transition nanodroplets (CNPs) with strong near-infrared (NIR) absorption, good biocompatibility, excellent photoacoustic (PA) and ultrasound (US) contrast, and high photothermal-conversion efficiency are reported in this study...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28335888/second-and-third-generation-drugs-for-immuno-oncology-treatment-the-more-the-better
#4
REVIEW
Wolfram C M Dempke, Klaus Fenchel, Peter Uciechowski, Stephen P Dale
Recent success in cancer immunotherapy (anti-CTLA-4, anti-PD1/PD-L1) has confirmed the hypothesis that the immune system can control many cancers across various histologies, in some cases producing durable responses in a way not seen with many small-molecule drugs. However, only less than 25% of all patients do respond to immuno-oncology drugs and several resistance mechanisms have been identified (e.g. T-cell exhaustion, overexpression of caspase-8 and β-catenin, PD-1/PD-L1 gene amplification, MHC-I/II mutations)...
March 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28332756/a-fluorescent-sensing-of-nerve-agent-simulant-with-dual-emissions-at-wide-ph-range-in-aqueous-solution
#5
Youngsam Kim, Yoon Jeong Jang, Sandip V Mulay, Thuy-Tien T Nguyen, David G Churchill
A new 1,8-naphthalimide-based fluorescent probe for the detection of diethyl cyanophosphonate, a very common nerve agent simulant, was designed, synthesized and characterized fully. The probe showed around 50-fold enhancement of fluorescence intensity over other nerve agent simulants. Importantly, the probe is able to work under aqueous conditions at wide pH range. Two reactive groups, the oxime and phenol, allowed a dual emission with different kinetic reaction. The reaction of diethyl cyanophosphonate with the oxime group occurred in advance; the resulting time-response of fluorescence enhancement was observed within ~30 s...
March 23, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28331908/il-1%C3%AE-is-an-innate-immune-sensor-of-microbial-proteolysis
#6
Christopher N LaRock, Jordan Todd, Doris L LaRock, Joshua Olson, Anthony J O'Donoghue, Avril A B Robertson, Matthew A Cooper, Hal M Hoffman, Victor Nizet
Interleukin-1β (IL-1β) is a key proinflammatory cytokine that drives antimicrobial immune responses. IL-1β is aberrantly activated in autoimmune diseases, and IL-1β inhibitors are used as therapeutic agents to treat patients with certain autoimmune disorders. Review of postmarketing surveillance of patients receiving IL-1β inhibitors found a disproportionate reporting of invasive infections by group A Streptococcus (GAS). IL-1β inhibition increased mouse susceptibility to GAS infection, but IL-1β was produced independent of canonical inflammasomes...
August 2016: Science Immunology
https://www.readbyqxmd.com/read/28330500/larvicidal-activity-of-phytosteroid-compounds-from-leaf-extract-of-solanum-nigrum-against-culex-vishnui-group-and-anopheles-subpictus
#7
Anjali Rawani, Anushree Singha Ray, Anupam Ghosh, Mary Sakar, Goutam Chandra
BACKGROUND: Vector control is facing a menace due to the appearance of resistance to synthetic insecticides. Insecticides of plant origin may provide appropriate substitute biocontrol techniques in the future. The present study was carried out to investigate the bio control potentiality of active ingredient isolated from chloroform: methanol (1:1 v/v) extract of mature leaves of Solanum nigrum L. (Solanaceae) against early 3rd instar larvae of Culex vishnui group (comprising of Cx. vishnui Theobald, Cx...
March 23, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28330171/purification-and-characterization-of-endo-%C3%AE-1-4-d-glucanase-from-trichoderma-harzianum-strain-hzn11-and-its-application-in-production-of-bioethanol-from-sweet-sorghum-bagasse
#8
Zabin K Bagewadi, Sikandar I Mulla, Harichandra Z Ninnekar
An acidophilic-solvent-thermostable endo β-1,4-D-glucanase produced from a potential Trichoderma harzianum strain HZN11 was purified to homogeneity by DEAE-Sepharose and Sephadex G-100 chromatography with 33.12 fold purification with specific activity of 66.25 U/mg and molecular mass of ~55 kDa. The optimum temperature and pH were 60 °C and 5.5 retaining 76 and 85 % of activity after 3 h, respectively. It showed stability between pH 4.5-6.0 and temperature between 50-70 °C indicating thermostability...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28328352/identification-isolation-and-phylogenetic-analysis-of-clostridium-perfringens-type-a-and-type-c-from-wild-boar-sus-scrofa-in-the-people-s-republic-of-china
#9
Meng Li, Xu Zhang, Lingwei Zhu, Haifeng Wang, Na Zhao, Jing Luo, Chengmin Wang, Yutian Wang, Yanhua Liu, Wei Zhou, Bikai Zhang, Huancheng Guo, Hongxuan He
Clostridium perfringens is a Gram-positive, anaerobic, spore-forming bacterium that can induces gas gangrene or enteritis in poultry and humans and many other mammalian species. Here, we report an outbreak of C. perfringens type A and type C coinfection in wild boars ( Sus scrofa ). In February 2016, 10 dead wild boars, including two fresh carcasses, were found in Zhaosu County, Xinjiang Province, People's Republic of China. The two fresh carcasses were included in this study. Two strains of C. perfringens were isolated, identified, genotyped, and phylogenetically analyzed...
March 22, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28328033/effects-of-molecular-weight-and-cationization-agent-on-the-sensitivity-of-bi-cluster-secondary-ion-mass-spectrometry
#10
Makiko Fujii, Rie Shishido, Takaya Satoh, Shigeru Suzuki, Jiro Matsuo
RATIONALE: Bi cluster secondary ion mass spectrometry (SIMS) is one of the most promising tools for precise analysis of synthetic polymers. However, the sensitivity in the high-mass region is still insufficient compared with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS). Accordingly, the effects of metal assistance (cationization agents) were investigated in this study. METHODS: To investigate the effects caused by varying the ionization agent, three different polyethylene glycol (PEG) samples were prepared, one with an Ag-deposited film, and two others mixed with Ag and Na, respectively...
July 30, 2016: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28314261/peroxiredoxin-expression-of-human-osteosarcoma-cells-is-influenced-by-cold-atmospheric-plasma-treatment
#11
Denis Gümbel, Nadine Gelbrich, Matthias Napp, Georg Daeschlein, Axel Kramer, Axel Sckell, Martin Burchardt, Axel Ekkernkamp, Matthias B Stope
BACKGROUND/AIM: To evaluate the potential involvement of redox-specific signalling pathways in cold atmospheric plasma (CAP)-induced apoptosis on human osteosarcoma cells. MATERIALS AND METHODS: Osteosarcoma cell lines were treated with CAP with or without antioxidative agents and seeded in cell culture plates. Cell proliferation was determined by counting viable cells. Carrier gas-treated cells served as control. Peroxiredoxin (PRX) 1-3 expression and secretion were assessed...
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28290183/synthesis-of-ultrasound-contrast-agents-characteristics-and-size-distribution-analysis-secondary-publication
#12
Hak Jong Lee, Tae-Jong Yoon, Young Il Yoon
Purpose: The purpose of this study was to establish a method for ultrasound (US) contrast agent synthesis and to evaluate the characteristics of the synthesized US contrast agent. Methods: A US contrast agent, composed of liposome and sulfur hexafluoride (SF6), was synthesized by dissolving 21 μmol 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine (DPPC, C40H80NO8P), 9 μmol cholesterol, and 1.9 μmol of dihexadecylphosphate (DCP, [CH3(CH2)15O]2P(O)OH) in chloroform...
February 14, 2017: Ultrasonography
https://www.readbyqxmd.com/read/28289314/nonlinear-ultrasound-imaging-of-nanoscale-acoustic-biomolecules
#13
David Maresca, Anupama Lakshmanan, Audrey Lee-Gosselin, Johan M Melis, Yu-Li Ni, Raymond W Bourdeau, Dennis M Kochmann, Mikhail G Shapiro
Ultrasound imaging is widely used to probe the mechanical structure of tissues and visualize blood flow. However, the ability of ultrasound to observe specific molecular and cellular signals is limited. Recently, a unique class of gas-filled protein nanostructures called gas vesicles (GVs) was introduced as nanoscale (∼250 nm) contrast agents for ultrasound, accompanied by the possibilities of genetic engineering, imaging of targets outside the vasculature and monitoring of cellular signals such as gene expression...
February 13, 2017: Applied Physics Letters
https://www.readbyqxmd.com/read/28287618/metabolomics-of-the-tick-borrelia-interaction-during-the-nymphal-tick-blood-meal
#14
J Charles Hoxmeier, Amy C Fleshman, Corey D Broeckling, Jessica E Prenni, Marc C Dolan, Kenneth L Gage, Lars Eisen
The causal agents of Lyme disease in North America, Borrelia burgdorferi and Borrelia mayonii, are transmitted primarily by Ixodes scapularis ticks. Due to their limited metabolic capacity, spirochetes rely on the tick blood meal for nutrients and metabolic intermediates while residing in the tick vector, competing with the tick for nutrients in the blood meal. Metabolomics is an effective methodology to explore dynamics of spirochete survival and multiplication in tick vectors before transmission to a vertebrate host via tick saliva...
March 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28286606/aspects-of-carbon-monoxide-in-form-of-co-releasing-molecules-used-in-cancer-treatment-more-light-on-the-way
#15
REVIEW
Malamati Kourti, Wen G Jiang, Jun Cai
Carbon monoxide (CO) has always been recognised as a toxic gas, due to its higher affinity for haemoglobin than oxygen. However, biological studies have revealed an intriguing role for CO as an endogenous signalling molecule, a gasotransmitter. CO is demonstrated to exert many cellular activities including anti-inflammatory, antiapoptotic, and antiproliferative activities. In animal studies, CO gas administration can prevent tissues from hypoxia or ischemic-reperfusion injury. As a result, there are a plethora of reports dealing with the biological applications of CO and CO-releasing molecules (CORMs) in inflammatory and vascular diseases...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28286602/climate-change-allergy-and-asthma-and-the-role-of-tropical-forests
#16
REVIEW
Gennaro D'Amato, Carolina Vitale, Nelson Rosario, Herberto Josè Chong Neto, Deborah Carla Chong-Silva, Francisco Mendonça, Josè Perini, Loraine Landgraf, Dirceu Solé, Mario Sánchez-Borges, Ignacio Ansotegui, Maria D'Amato
BACKGROUND: Tropical forests cover less than 10 per cent of all land area (1.8 × 107 km(2)) and over half of the tropical-forest area (1.1 × 107 Km(2)) is represented by humid tropical forests (also called tropical rainforests). The Amazon basin contains the largest rainforest on Earth, almost 5.8 million km(2), and occupies about 40% of South America; more than 60% of the basin is located in Brazil and the rest in Bolivia, Colombia, Ecuador, French Guiana, Guyana, Peru, Suriname and Venezuela...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28286597/extending-the-lifetime-of-hyperpolarized-propane-gas-through-reversible-dissolution
#17
Dudari B Burueva, Alexey S Romanov, Oleg G Salnikov, Vladimir V Zhivonitko, Yu-Wen Chen, Danila A Barskiy, Eduard Y Chekmenev, Dennis W Hwang, Kirill V Kovtunov, Igor V Koptyug
Hyperpolarized (HP) propane produced by the parahydrogen-induced polarization (PHIP) technique has been recently introduced as a promising contrast agent for functional lung magnetic resonance (MR) imaging. However, its short lifetime due to a spin-lattice relaxation time T1 of less than 1 s in the gas phase is a significant translational challenge for its potential biomedical applications. The previously demonstrated approach for extending the lifetime of the HP propane state through long-lived spin states allows the HP propane lifetime to be increased by a factor of ∼3...
March 2, 2017: Journal of Physical Chemistry. C, Nanomaterials and Interfaces
https://www.readbyqxmd.com/read/28284551/characterization-of-the-reactivity-and-chlorinated-products-of-carbazole-during-aqueous-chlorination
#18
Xiong Xu, Donghong Wang, Chunmei Li, Hongru Feng, Zijian Wang
Carbazole in source water is a potential precursor for toxic chlorocarbazoles in drinking water when chlorine is used as a disinfection agent in drinking water treatment plants. However, the reactivity of carbazole and the specific structures and predominant analogues of chlorocarbazoles produced during aqueous chlorination remain unknown. In this study, the aqueous chlorination of carbazole was performed to characterize its reactivity and the chlorinated products. Chlorocarbazoles generated from carbazole were identified by a comprehensive two-dimensional gas chromatography-mass spectrometry method, and their molecular structures were predicted by the Fukui index of electrophilic attack, f(-1)(r)...
March 9, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28284060/phosphite-shifts-physiological-and-hormonal-profile-of-monterey-pine-and-delays-fusarium-circinatum-progression
#19
Andreia Cerqueira, Artur Alves, Helder Berenguer, Barbara Correia, Aurelio Gómez-Cadenas, Julio Javier Diez, Pedro Monteiro, Glória Pinto
Fusarium circinatum is the causal agent of pitch canker disease affecting Pinus spp. and Pseudotsuga menziesii worldwide. Under strict quarantine measures, alternative approaches for disease control are necessary. Phosphite (Phi) salts are known for their fungicidal activity and as plant resistance elicitors; however, its potential is yet to be acknowledged in the Pinus-F. circinatum model. The main aim of this study was to assess whether the application of a Phi-based commercial formulation would delay the progression of the pitch canker on Pinus radiata plants, and on the in vitro fungal growth...
February 27, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28283327/pharmacokinetics-of-perfluorobutane-after-intra-venous-bolus-injection-of-sonazoid-in-healthy-chinese-volunteers
#20
Pengfei Li, Susan Hoppmann, Ping Du, Huiling Li, Paul M Evans, Siver A Moestue, Weiyue Yu, Fang Dong, Hongchuan Liu, Lihong Liu
Sonazoid is an ultrasound contrast agent based on microbubbles (MB) containing perfluorobutane (PFB) gas. Sonazoid is approved in Japan, Korea and Norway for contrast-enhanced ultrasonography of focal liver lesions and focal breast lesions (Japan only). The objective of this study was to determine the pharmacokinetics (PKs) and safety of Sonazoid in Chinese healthy volunteers (HVs) and to evaluate the potential for ethnic differences in PKs between Chinese and Caucasian HVs. Sonazoid was administered as an intra-venous bolus injection at the clinical dose of 0...
March 7, 2017: Ultrasound in Medicine & Biology
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