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https://www.readbyqxmd.com/read/28628631/computational-explanation-for-bioactivation-mechanism-of-targeted-anticancer-agents-mediated-by-cytochrome-p450s-a-case-of-erlotinib
#1
Chun-Zhi Ai, Yong Liu, Wei Li, De-Meng Chen, Xin-Xing Zhu, Ya-Wei Yan, Du-Chu Chen, Yi-Zhou Jiang
EGFR inhibitors, even with therapeutics superiorities in anticancer, can cause idiosyncratic pulmonary and hepatic toxicities that are associated with the reactive electrophile bioactivated by Cytochrome P450s (P450s). Until now, neither has the electrophilic intermediate been caught experimentally, nor has the subtle mechanism been declared. Herein, the underlying mechanism of bioactivation mediated by P450s was explored by DFT calculations for a case of EGFR inhibitor, Erlotinib. Based on the calculation and analysis, we suggest that with other metabolites, reactive electrophiles of Erlotinib: epoxide and quinine-imine, can be generated by several steps along the oxidative reaction pathway...
2017: PloS One
https://www.readbyqxmd.com/read/28624728/nitrite-production-from-urine-for-sulfide-control-in-sewers
#2
Min Zheng, Zhiqiang Zuo, Yizhen Zhang, Yujia Cui, Qian Dong, Yanchen Liu, Xia Huang, Zhiguo Yuan
Most commonly used methods for sewer sulfide control involves dosing chemical agents to wastewater, which incurs high operational costs. Here, we propose and demonstrate a cost-effective and environmentally attractive approach to sewer sulfide control through urine separation and its subsequent conversion to nitrite prior to intermittent dosage to sewers. Urine collected from a male toilet urinal was fed to laboratory-scale sequencing batch reactors. The reactors stably converted roughly 50% of the nitrogen in urine to nitrite, with high abundance (at 17...
May 23, 2017: Water Research
https://www.readbyqxmd.com/read/28620396/identification-of-a-potential-isr-determinant-from-pseudomonas-aeruginosa-pm12-against-fusarium-wilt-in-tomato
#3
Sabin Fatima, Tehmina Anjum
Biocontrol of plant diseases through induction of systemic resistance is an environmental friendly substitute to chemicals in crop protection measures. Different biotic and abiotic elicitors can trigger the plant for induced resistance. Present study was designed to explore the potential of Pseudomonas aeruginosa PM12 in inducing systemic resistance in tomato against Fusarium wilt. Initially the bioactive compound, responsible for ISR, was separated and identified from extracellular filtrate of P. aeruginosa PM12...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28603759/experimental-data-on-compressive-strength-and-durability-of-sulfur-concrete-modified-by-styrene-and-bitumen
#4
M Dehestani, E Teimortashlu, M Molaei, M Ghomian, S Firoozi, S Aghili
In this data article experimental data on the compressive strength, and the durability of styrene and bitumen modified sulfur concrete against acidic water and ignition are presented. The percent of the sulfur cement and the gradation of the aggregates used are according to the ACI 548.2R-93 and ASTM 3515 respectively. For the styrene modified sulfur concrete different percentages of styrene are used. Also for the bitumen modified sulfur concrete, different percentages of bitumen and the emulsifying agent (triton X-100) are utilized...
August 2017: Data in Brief
https://www.readbyqxmd.com/read/28603579/in-situ-optical-reflectance-difference-observations-of-co-oxidation-over-pd-100
#5
Willem G Onderwaater, Andriy Taranovskyy, Gertjan C van Baarle, Joost W M Frenken, Irene M N Groot
Using a home-built reflectometer, we have investigated the changes in the optical reflectivity of a Pd(100) model catalyst during CO oxidation under high-pressure, high-temperature conditions. We observe changes in optical contrast when exposing the surface to CO oxidation conditions at 200 mbar from room temperature up to 400 °C. These changes in reflectivity are a result both of the formation of a surface oxide layer and of a change in surface roughness because of gas exposure. However, the reflectivity is more sensitive to the presence of a thin, flat oxide layer than to surface roughness...
June 1, 2017: Journal of Physical Chemistry. C, Nanomaterials and Interfaces
https://www.readbyqxmd.com/read/28602305/identification-of-non-intentionally-added-substances-in-food-packaging-nano-films-by-gas-and-liquid-chromatography-coupled-to-orbitrap-mass-spectrometry
#6
M J Martínez-Bueno, M D Hernando, S Uclés, L Rajski, S Cimmino, A R Fernández-Alba
The control of chemical migration from new functionalized food contact materials (FCMs) is a challenge for meeting food safety requirements. The non-intentionally added substances (NIAS) constitute a group of chemicals that are not applied, but may be introduced or formed during the production process of FCMs. This study describes a multi-analytical approach for the evaluation of unknown substances that migrate from FCMs. A case study is presented using a developed polymer consisting of a monolayer film with polylactic acid (PLA), polylimonene (PL) and zinc oxide nanoparticles (ZnO NPs)...
September 1, 2017: Talanta
https://www.readbyqxmd.com/read/28600908/a-rapid-qualitative-assay-for-detection-of-clostridium-perfringens-in-canned-food-products
#7
Gayatri Ashwinkumar Dave
Clostridium perfringens (MTCC 1349) is a Gram-positive, anaerobic, endospore forming, and rod-shaped bacterium. This bacterium produces a variety of toxins under strict anaerobic environment. C. perfringens can grow at temperatures ranging between 20°C and 50°C. It is the major causetive agent for gas gangrene, cellulitis, septicemia, necrotic enteritis and food poisoning, which are common toxin induced conditions noted in human and animals. C. perfringens can produce produce four major types of toxins that are used for the classification of strains, classified under type A-E...
2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/28600624/desflurane-usage-during-anesthesia-with-and-without-n2o-using-flow-i-automatic-gas-control-with-three-different-wash-in-speeds
#8
Robrecht De Medts, Rik Carette, Andre M De Wolf, Jan F A Hendrickx
AGC(®) (Automatic Gas Control) is the FLOW-i's automated low flow tool (Maquet, Solna, Sweden) that target controls the inspired O2 (FIO2) and end-expired desflurane concentration (FAdes) while (by design) exponentially decreasing fresh gas flow (FGF) during wash-in to a maintenance default FGF of 300 mL min(-1). It also offers a choice of wash-in speeds for the inhaled agents. We examined AGC performance and hypothesized that the use of lower wash-in speeds and N2O both reduce desflurane usage (Vdes). After obtaining IRB approval and patient consent, 78 ASA I-II patients undergoing abdominal surgery were randomly assigned to 1 of 6 groups (n = 13 each), depending on carrier gas (O2/air or O2/N2O) and wash-in speed (AGC speed 2, 4, or 6) of desflurane, resulting in groups air/2, air/4, air/6, N2O/2, N2O/4, and N2O/6...
June 9, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/28596949/new-methodologies-for-the-preparation-of-carbon-11-labeled-radiopharmaceuticals
#9
REVIEW
Kenneth Dahl, Christer Halldin, Magnus Schou
PURPOSE: This short review aims to cover the more recent and promising developments of carbon-11 ((11)C) labeling radiochemistry and its utility in the production of novel radiopharmaceuticals, with special emphasis on methods that have the greatest potential to be translated for clinical positron emission tomography (PET) imaging. METHODS: A survey of the literature was undertaken to identify articles focusing on methodological development in (11)C chemistry and their use within novel radiopharmaceutical preparation...
2017: Clinical and Translational Imaging: Reviews in Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28594358/activation-of-magnesium-lignosulfonate-and-kraft-lignin-influence-on-the-properties-of-phenolic-resin-based-composites-for-potential-applications-in-abrasive-materials
#10
Lukasz Klapiszewski, Artur Jamrozik, Beata Strzemiecka, Danuta Matykiewicz, Adam Voelkel, Teofil Jesionowski
Magnesium lignosulfonate and kraft lignin were activated by different oxidizing agents for use in phenolic resin composites used for the production of abrasive components. The physicochemical properties of the oxidized materials were analyzed by Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), dynamic mechanical-thermal analysis (DMTA) and inverse gas chromatography (IGC). The homogeneity of the model abrasive composites containing the studied products was assessed based on observations obtained using a scanning electron microscope (SEM)...
June 8, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28589070/agranulocytosis-sequelae-of-chronic-cocaine-use-case-series-and-literature-review
#11
Roma Srivastava, Maira Rizwan, Muhammad Omer Jamil, Palaniandy Kogulan, Donna Salzman
Agranulocytosis is a rare condition with a reported incidence ranging from one to five cases per million population per year. Most commonly, agranulocytosis is secondary to chemotherapeutic agents, however, other medications have also been associated with it. An immune mediated destruction of circulating granulocytes and/or granulocyte precursors secondary to drug-dependent or drug-induced antibodies is the postulated mechanism. Agranulocytosis has also been reported secondary to recreational drug use...
May 3, 2017: Curēus
https://www.readbyqxmd.com/read/28588629/in-vitro-and-in-vivo-activity-of-artemisia-sieberi-against-trichomonas-gallinae
#12
M R Youssefi, M Abouhosseini Tabari, A A Moghadamnia
In Iranian folk medicine Artemisia sieberi has been used for treatment of parasite infections in human and animals. The present study was designed to evaluate the in vitro and in vivo effects of A. sieberi essential oil (EO) against Trichomonas gallinae. Trichomonas gallinae were recovered by wet mount method from infected native pigeons. The in vitro assays were accomplished in multi-well plates containing metronidazole (MTZ) as a standard antitrichomonal and EO in final concentrations of 2.5, 5, 10, 20, 50, and 100 μg/ml of culture medium containing 10(4) parasites...
2017: Iranian journal of veterinary research
https://www.readbyqxmd.com/read/28587401/antioxidant-properties-of-the-red-alga-asparagopsis-taxiformis-collected-on-the-north-west-algerian-coast
#13
Zoheir Mellouk, Ilhem Benammar, Djamil Krouf, Makhlouf Goudjil, Meriem Okbi, Willy Malaisse
The aim of the present study was to evaluate the total phenolic and lipid content, fatty acids profiles and in vitro antioxidant activities of aqueous and solvent extracts of the red seaweed Asparagopsis taxiformis, through six different investigations. The present study demonstrated that phenol contents (mg gallic acid/g dry weight) were highest in the aqueous and methanolic extracts, followed by the ethanolic, hydroethanolic and hydromethanolic extracts. The lowest phenol contents were identified in the three remaining extracts: Butanolic, petroleum ether and acetone extracts...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28584318/albumin-adducts-and-urinary-metabolites-resulting-from-occupational-exposure-to-1-5-naphthalene-diisocyanate
#14
Ovnair Sepai, Gabriele Sabbioni
OBJECTIVES: 1,5-Naphthalene diisocyanate (NDI) is used in the plastic industry as a curing agent. 1,5-Naphthalene diisocyanate is classified as a sensitizing agent. The objective of this study has been to develop biomonitoring methods for the evaluation of exposure to NDI. MATERIAL AND METHODS: We obtained blood and urine samples from a group of 20 male workers exposed to NDI. The workers answered a questionnaire about their exposure history, job description, the number of years with the company and the time spent working with NDI over the 10 days of the study...
April 20, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/28584285/oxygen-atoms-are-critical-in-rendering-thp-1-leukaemia-cells-susceptible-to-cold-physical-plasma-induced-apoptosis
#15
Sander Bekeschus, Kristian Wende, Mohamed Mokhtar Hefny, Katrin Rödder, Helena Jablonowski, Anke Schmidt, Thomas von Woedtke, Klaus-Dieter Weltmann, Jan Benedikt
Cold physical plasma has been suggested as a powerful new tool in oncology. However, some cancer cells such as THP-1 leukaemia cells have been shown to be resistant towards plasma-induced cell death, thereby serving as a good model for optimizing plasmas in order to foster pro-apoptotic anticancer effects. A helium/oxygen radio frequency driven atmospheric plasma profoundly induced apoptosis in THP-1 cells whereas helium, humidified helium, and humidified helium/oxygen plasmas were inefficient. Hydrogen peroxide - previously shown as central plasma-derived agent - did not participate in the killing reaction but our results suggest hypochlorous acid to be responsible for the effect observed...
June 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28583773/anesthetic-synergy-between-two-n-alkanes
#16
Robert J Brosnan, Fabíola B Fukushima, Trung L Pham
OBJECTIVE: N-butane and n-pentane can both produce general anesthesia. Both compounds potentiate γ-aminobutyric acid type A (GABAA) receptor function, but only butane inhibits N-methyl-d-aspartate (NMDA) receptors. It was hypothesized that butane and pentane would exhibit anesthetic synergy due to their different actions on ligand-gated ion channels. STUDY DESIGN: Prospective experimental study. ANIMALS: A total of four Xenopus laevis frogs and 43 Sprague-Dawley rats...
January 11, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28581734/nitrosamine-formation-in-amine-based-co2-capture-in-the-absence-of-no2-molecular-modeling-and-experimental-validation
#17
Huancong Shi, Teeradet Supap, Raphael O Idem, Don Gelowitz, Colin Campbell, Max Ball
In this nitrosamine study, a computational chemistry approach was used to elucidate and/or verify different nitrosamine formation mechanisms and pathways. These included nitrosamine formation under acid or basic environments in the presence of NO, O2, SO2, and CO2 without NO2. The results clearly showed the circumstances by which nitrosamine could be formed without NO2 via 2 different types of mechanisms namely, addition and elimination forming N-N bond before proton transfer and proton transfer before N-N bond formation, respectively...
June 5, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28576138/changes-in-pancreatic-histology-insulin-secretion-and-oxidative-status-in-diabetic-rats-following-treatment-with-ficus-deltoidea-and-vitexin
#18
Samsulrizal Nurdiana, Yong Meng Goh, Hafandi Ahmad, Sulaiman Md Dom, Nur Syimal'ain Azmi, Noor Syaffinaz Noor Mohamad Zin, Mahdi Ebrahimi
BACKGROUND: The potential application of Ficus deltoidea and vitexin for the management of symptomatologies associated with diabetes mellitus (DM) has gained much attention. However, less firm evidence comes from data to augment our understanding of the role of F. deltoidea and vitexin in protecting pancreatic β-cells. The aim of this study was to assess histological and oxidative stress changes in the pancreas of streptozotocin (STZ)-induced diabetic rats following F. deltoidea extract and vitexin treatment...
June 2, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28572754/functional-amplification-and-preservation-of-human-gut-microbiota
#19
Nadia Gaci, Prem Prashant Chaudhary, William Tottey, Monique Alric, Jean-François Brugère
Background: The availability of fresh stool samples is a prerequisite in most gut microbiota functional studies. Objective: Strategies for amplification and long-term gut microbiota preservation from fecal samples would favor sample sharing, help comparisons and reproducibility over time and between laboratories, and improve the safety and ethical issues surrounding fecal microbiota transplantations. Design: Taking advantage of in vitro gut-simulating systems, we amplified the microbial repertoire of a fresh fecal sample and assessed the viability and resuscitation of microbes after preservation with some common intracellular and extracellular acting cryoprotective agents (CPAs), alone and in different combinations...
2017: Microbial Ecology in Health and Disease
https://www.readbyqxmd.com/read/28567612/uncontrolled-delivery-of-liquid-volatile-anaesthetic-when-using-the-anaesthetic-conserving-device
#20
Igor Karnjuš, Dušan Mekiš, Miljenko Križmarić
During patient sedation with liquid volatile anaesthetic, some problems may occur through a process called auto-pumping, defined as an expansion of bubbles inside the syringe, which can lead to uncontrolled anaesthetic delivery. The study examined how the temperature of liquid volatile anaesthetics (sevoflurane and isoflurane) and the presence of gas bubbles in the syringe affect the occurrence of auto-pumping when using the anaesthetic conserving device (ACD, AnaConDa™, Sedana Medical, Uppsala, Sweden). Four different circumstances for each volatile anaesthetic were tested with a bench study: volatile anaesthetic at room temperature or precooled with and without the presence of gas bubbles in the syringe...
May 31, 2017: Journal of Clinical Monitoring and Computing
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