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https://www.readbyqxmd.com/read/29656941/submucosal-gland-myoepithelial-cells-are-reserve-stem-cells-that-can-regenerate-mouse-tracheal-epithelium
#1
Thomas J Lynch, Preston J Anderson, Pavana G Rotti, Scott R Tyler, Adrianne K Crooke, Soon H Choi, Daniel T Montoro, Carolyn L Silverman, Weam Shahin, Rui Zhao, Chandler W Jensen-Cody, Andrea Adamcakova-Dodd, T Idil Apak Evans, Weiliang Xie, Yulong Zhang, Hongmei Mou, B Paul Herring, Peter S Thorne, Jayaraj Rajagopal, Charles Yeaman, Kalpaj R Parekh, John F Engelhardt
The mouse trachea is thought to contain two distinct stem cell compartments that contribute to airway repair-basal cells in the surface airway epithelium (SAE) and an unknown submucosal gland (SMG) cell type. Whether a lineage relationship exists between these two stem cell compartments remains unclear. Using lineage tracing of glandular myoepithelial cells (MECs), we demonstrate that MECs can give rise to seven cell types of the SAE and SMGs following severe airway injury. MECs progressively adopted a basal cell phenotype on the SAE and established lasting progenitors capable of further regeneration following reinjury...
April 6, 2018: Cell Stem Cell
https://www.readbyqxmd.com/read/29649032/airway-management-practice-in-adults-with-an-unstable-cervical-spine-the-harborview-medical-center-experience
#2
Michael G Holmes, Armagan Dagal, Bryan A Feinstein, Aaron M Joffe
BACKGROUND: Airway management in the presence of acute cervical spine injury (CSI) is challenging. Because it limits cervical spine motion during tracheal intubation and allows for neurological examination after the procedure, awake fiberoptic bronchoscopy (FOB) has traditionally been recommended. However, with the widespread availability of video laryngoscopy (VL), its use has declined dramatically. Our aim was to describe the frequency of airway management techniques used in patients with CSI at our level I trauma center and report the incidence of neurological injury attributable to airway management...
April 11, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29644893/activation-of-the-nfkb-pathway-alters-the-phenotype-of-mscs-in-the-tracheal-aspirates-of-preterm-infants-with-severe-bpd
#3
Tobias Reicherzer, Susanne Häffner, Tayyab Shahzad, Judith Gronbach, Josef Mysliwietz, Christoph Huebener, Uwe Hasbargen, Jan Gertheiss, Andreas Schulze, Saverio Bellusci, Rory E Morty, Anne Hilgendorff, Harald Ehrhardt
Mesenchymal stromal cells (MSCs) are released into the airways of preterm infants following lung injury. These cells display a pro-inflammatory phenotype and are associated with development of severe bronchopulmonary dysplasia (BPD). We aimed to characterize the functional properties of MSCs obtained from tracheal aspirates of 50 preterm infants who required invasive ventilation. Samples were separated by disease severity. The increased proliferative capacity of MSCs was associated with longer duration of mechanical ventilation and higher severity of BPD...
April 12, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29644295/successful-management-of-suicidal-cut-throat-injury-with-internal-jugular-tracheal-and-esophageal-transection-a-case-report
#4
E H Naqvi Sayyed, Akhtar Sadik, M H Beg, Haseen Azam, Raza Nadeem, Ali Eram
No abstract text is available yet for this article.
February 2018: Trauma case reports
https://www.readbyqxmd.com/read/29627046/tracheal-injuries-complicating-prolonged-intubation-and-tracheostomy
#5
REVIEW
Joel D Cooper
Respiratory care advances such as the introduction of ventilatory assistance have been associated with postintubation airway stenosis resulting from tracheal injury at the site of the inflatable cuff on endotracheal or tracheostomy tubes. Low-pressure cuffs have significantly reduced this occurrence. Loss of airway stability at the site of a tracheostomy stoma may result in tracheal stenosis. Subglottic stenosis may result from a high tracheostomy site at, or just inferior to, the cricoid arch, or to malposition of an endotracheal tube cuff...
May 2018: Thoracic Surgery Clinics
https://www.readbyqxmd.com/read/29627043/birth-of-airway-surgery-and-evolution-over-the-past-fifty-years
#6
REVIEW
Jean Deslauriers
Significant developments in airway surgery occurred following the introduction of mechanical ventilators and intubation with cuffed endotracheal tubes during the poliomyelitis epidemic of the 1950s. The resulting plethora of postintubation injuries provided extensive experience with resection and reconstruction of stenotic tracheal lesions. In the early 1960s, it was thought that no more 2 cm of trachea could be removed. By the late 1960s, this was challenged owing to better knowledge of airway anatomy and blood supply, tension-releasing maneuvers, and improved anesthetic techniques...
May 2018: Thoracic Surgery Clinics
https://www.readbyqxmd.com/read/29617417/role-of-protein-kinase-c-delta-in-regulating-platelet-activation-and-platelet-leukocyte-interaction-during-sepsis
#7
Elisabetta Liverani, Mark J Mondrinos, Shuang Sun, Satya P Kunapuli, Laurie E Kilpatrick
Sepsis is characterized by an intense systemic inflammatory response activating a cascade of proinflammatory events resulting in leukocyte dysregulation and host tissue damage. The lung is particularly susceptible to systemic inflammation, leading to acute lung injury. Key to inflammation-induced lung damage is the excessive migration of neutrophils across the vascular endothelium. The mechanisms which regulate neutrophil activation and migration in sepsis are not well defined but there is growing evidence that platelets are actively involved and play a key role in microvascular permeability and neutrophil-mediated organ damage...
2018: PloS One
https://www.readbyqxmd.com/read/29605358/surgical-management-of-children-presenting-with-surgical-needed-tracheal-stenosis
#8
Marie-Eva Rossi, Eric Moreddu, Loïc Macé, Jean-Michel Triglia, Richard Nicollas
OBJECTIVES: The purpose of this work was to assess epidemiological aspects, surgical approach, morbidity and mortality rates of patients presenting with tracheal stenosis requiring surgery, and the evolution of surgical techniques over the last years. METHODS: We performed a retrospective observational study from 1990 to 2017 in a pediatric tertiary-care center with needing surgery for tracheal stenosis. We analyzed clinical patients' characteristics, type of stenosis, type of surgery and follow-up...
May 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29595879/capturing-the-multifactorial-nature-of-ards-two-hit-approach-to-model-murine-acute-lung-injury
#9
Sandra Hoegl, Nana Burns, Martín Angulo, Daniel Francis, Christopher M Osborne, Tingting W Mills, Michael R Blackburn, Holger K Eltzschig, Christine U Vohwinkel
Severe acute respiratory distress syndrome (ARDS) presents typically with an initializing event, followed by the need for mechanical ventilation. Most animal models of ALI are limited by the fact that they focus on a singular cause of acute lung injury (ALI) and therefore fail to mimic the complex, multifactorial pathobiology of ARDS. To better capture this scenario, we provide a comprehensive characterization of models of ALI combining two injuries: intra tracheal (i.t.) instillation of LPS or hypochloric acid (HCl) followed by ventilator-induced lung injury (VILI)...
March 2018: Physiological Reports
https://www.readbyqxmd.com/read/29588652/what-is-the-treatment-of-tracheal-lesions-associated-with-traditional-thyroidectomy-case-report-and-systematic-review
#10
REVIEW
Nicola Tartaglia, Roberta Iadarola, Alessandra Di Lascia, Pasquale Cianci, Alberto Fersini, Antonio Ambrosi
Aim: The aim of this study is to review the literature focusing on various treatments based on time of tracheal injury and on different surgeons' personal experience. Methods: We retrospectively reviewed all cases of total thyroidectomy performed at the University Surgical Department of Ospedali Riuniti of Foggia from 2006 to 2017. Only a single case of tracheal lesion due to traditional total thyroidectomy was found. An extensive search of the relevant literature was carried out using MEDLINE (PubMed)...
2018: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/29587145/spatial-temporal-lineage-restrictions-of-embryonic-p63-progenitors-establish-distinct-stem-cell-pools-in-adult-airways
#11
Ying Yang, Paul Riccio, Michael Schotsaert, Munemasa Mori, Jining Lu, Dong-Kee Lee, Adolfo García-Sastre, Jianming Xu, Wellington V Cardoso
Basal cells (BCs) are p63-expressing multipotent progenitors of skin, tracheoesophageal and urinary tracts. p63 is abundant in developing airways; however, it remains largely unclear how embryonic p63+ cells contribute to the developing and postnatal respiratory tract epithelium, and ultimately how they relate to adult BCs. Using lineage-tracing and functional approaches in vivo, we show that p63+ cells arising from the lung primordium are initially multipotent progenitors of airway and alveolar lineages but later become restricted proximally to generate the tracheal adult stem cell pool...
March 26, 2018: Developmental Cell
https://www.readbyqxmd.com/read/29575278/severe-postintubation-tracheobronchial-rupture
#12
Sergio Vedovati, Francesco Consonni, Mirco Nacoti, Ezio Bonanomi
Tracheal injury is a rare complication after pediatric intubation. The choice of treatment depends on the size of the lesion and on the underlying disease. We present a complex case of severe tracheal injury treated with success with tracheal stent positioning.
March 25, 2018: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29561395/suffocation-from-balloon-bronchoplasty
#13
Jorge L Morales-Estrella, Michael Machuzak, Bohdan Pichurko, Hanine Inaty, Atul C Mehta
Negative pressure pulmonary edema is a well-described complication of upper airway obstruction. However, the simultaneous occurrence of blood-stained secretions and petechial tracheobronchial hemorrhage are rarely recognized and a potential complication of transient intentional occlusion of the airways. We described a case of "hemorrhagic bronchial mucosa syndrome" and asymptomatic blood-tinged pulmonary edema after balloon bronchoplasty for a concentric tracheal stenosis using a flexible bronchoscopy...
April 2018: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/29536276/to-reduce-routine-computed-tomographic-angiography-for-thoracic-aortic-injury-assessment-in-level-ii-blunt-trauma-patients-using-three-mediastinal-signs-on-the-initial-chest-radiograph-a-preliminary-report
#14
John H Harris, William H Harris, Sanjay Jain, A Y Ferguson, David A Hill, Amy M Trahan
PURPOSE: CTA is routinely ordered on level II blunt thoraco-abdominally injured patients for assessment of injury to the thoracic aorta. The vast majority of such assessments are negative. The question being asked is, Does the accurate interpretation of the three mediastinal signs permit reliable determination of which patients need CTA for aortic assessment? The purpose of this investigation was to evaluate the role of three specifically selected mediastinal anatomic signs on the initial supine chest radiograph (CXR) of adult level II blunt thoraco-abdominally injured patients for the presence or absence of a mediastinal hematoma...
March 13, 2018: Emergency Radiology
https://www.readbyqxmd.com/read/29536186/nebulization-of-cyclic-arginine-glycine-d-aspartic-acid-peptide-grafted-and-drug-encapsulated-liposomes-for-inhibition-of-acute-lung-injury
#15
Hari R Desu, Laura A Thoma, George C Wood
PURPOSE: Acute lung injury (ALI) is a fatal syndrome in critically ill patients. It is characterized by lung edema and inflammation. Numerous pro-inflammatory mediators are released into alveoli. Among them, interleukin-1beta (IL-1β) causes an increase in solute permeability across the alveolar-capillary barrier leading to edema. It activates key effector cells (alveolar epithelial and endothelial cells) releasing inflammatory chemokines and cytokines. The purpose of the study was to demonstrate that nebulized liposomes inhibit ALI in vivo...
March 13, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29532142/medial-approach-for-the-resection-of-goiters-with-suprahyoid-retropharyngeal-or-substernal-extension
#16
Harry H Ching, Jacob B Kahane, Megan J Foggia, Annabel E Barber, Robert C Wang
BACKGROUND: Resection of massive goiters with suprahyoid, retropharyngeal, and substernal extension may not be amenable to standard approaches. This study evaluates a surgical approach allowing resection of massive goiters with minimal substernal and deep neck dissection. METHODS: Cases of thyroidectomy for goiters with substernal, retropharyngeal, or suprahyoid extension at a single institution from 2006 to 2017 were reviewed. The technique involves initial complete division of the medial thyroid tracheal attachments after identification of the RLN medial-inferiorly or superiorly...
March 12, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29521676/another-strategy-for-the-treatment-of-thyroglossal-duct-cyst-totally-endoscopic-surgery-by-breast-approach
#17
Rui Qu, Cunchuan Wang, Zhiyong Dong, Jinyi Li, Daosheng Liu
OBJECTIVE: Open surgery is the most common treatment of thyroglossal duct cyst (TGDC), but it leaves obvious neck scarring. This study aimed to explore the feasibility and strategy of total endoscopic procedure by breast approach to avoid such scarring on the neck. MATERIALS AND METHODS: This study reviewed 13 patients who underwent endoscopic resection of TGDC and 15 patients who underwent open resection of TGDC. We compared and analyzed factors including operative time, estimated blood loss, postoperative hospitalization, complications, and cosmetic effect...
March 7, 2018: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/29507415/mechanical-complications-and-outcomes-following-invasive-emergency-procedures-in-severely-injured-trauma-patients
#18
Manuel F Struck, Johannes K M Fakler, Michael Bernhard, Thilo Busch, Patrick Stumpp, Gunther Hempel, André Beilicke, Sebastian N Stehr, Christoph Josten, Hermann Wrigge
This study aimes to determine the complication rates, possible risk factors and outcomes of emergency procedures performed during resuscitation of severely injured patients. The medical records of patients with an injury severity score (ISS) >15 admitted to the University Hospital Leipzig from 2010 to 2015 were reviewed. Within the first 24 hours of treatment, 526 patients had an overall mechanical complication rate of 26.2%. Multivariate analysis revealed out-of-hospital airway management (OR 3.140; 95% CI 1...
March 5, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29483471/-tracheal-injury-successfully-treated-without-surgery-report-of-a-case
#19
Toshihiro Ikeda, Jun Nakano, Hiroyasu Yokomise
A 73-year-old man was injured after crashing his automobile into a concrete wall, and was admitted to our hospital with breathing difficulties. Chest computed tomography showed extensive mediastinal emphysema, right traumatic pneumothorax, and a suspected tracheal injury at the membranous region. Because of the associated tracheomalacia, the site of the tracheal injury was difficult to find by bronchoscopy. In addition, as the patient's respiratory condition was stable, surgical treatment was not chosen. Due to the continuous air leakage from the right lung, the patient underwent surgery after mediastinal and subcutaneous emphysema improved...
February 2018: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/29482594/tracheal-injury-detected-immediately-after-median-sternotomy-by-inexperienced-surgeons-two-case-reports
#20
Jun Takeshita, Kei Nishiyama, Atsushi Fukumoto, Suguru Ohira, Satoru Beppu, Nozomu Sasahashi, Nobuaki Shime
BACKGROUND: Although median sternotomy is standard during cardiac surgery, the procedure is associated with a risk of injury to mediastinal organs. Here, we discuss two cases of tracheal injury following median sternotomy during cardiac surgery. CASE PRESENTATION: Ventilation failure occurred in a 78-year-old Japanese man and a 71-year-old Japanese man after median sternotomy, and tracheal injury was identified. The sites of injury were directly repaired and covered with mediastinal fat tissue, following which ventilation was successful...
February 27, 2018: Journal of Medical Case Reports
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