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Administration in Emergency Medicine

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https://www.readbyqxmd.com/read/29736562/evaluation-of-brain-nuclear-medicine-imaging-tracers-in-a-murine-model-of-sepsis-associated-encephalopathy
#1
Dávid Szöllősi, Nikolett Hegedűs, Dániel S Veres, Ildikó Futó, Ildikó Horváth, Noémi Kovács, Bernadett Martinecz, Ádám Dénes, Daniel Seifert, Ralf Bergmann, Ondřej Lebeda, Zoltán Varga, Zoltán Kaleta, Krisztián Szigeti, Domokos Máthé
PURPOSE: The purpose of this study was to evaluate a set of widely used nuclear medicine imaging agents as possible methods to study the early effects of systemic inflammation on the living brain in a mouse model of sepsis-associated encephalopathy (SAE). The lipopolysaccharide (LPS)-induced murine systemic inflammation model was selected as a model of SAE. PROCEDURES: C57BL/6 mice were used. A multimodal imaging protocol was carried out on each animal 4 h following the intravenous administration of LPS using the following tracers: [99m Tc][2,2-dimethyl-3-[(3E)-3-oxidoiminobutan-2-yl]azanidylpropyl]-[(3E)-3-hydroxyiminobutan-2-yl]azanide ([99m Tc]HMPAO) and ethyl-7-[125 I]iodo-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate ([125 I]iomazenil) to measure brain perfusion and neuronal damage, respectively; 2-deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG) to measure cerebral glucose uptake...
May 7, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29735755/recommended-approaches-for-pharmacokinetic-natural-product-drug-interaction-research-a-napdi-center-commentary
#2
Mary F Paine, Danny D Shen, Jeannine S McCune
Sales of botanical dietary supplements and other purported medicinal natural products (NPs) have escalated over the past ~25 years, increasing the potential for NPs to precipitate clinically significant pharmacokinetic interactions with United States Food and Drug Administration (FDA)-approved medications (NP-drug interactions or NPDIs). Published NPDI studies to date often lack consistency in design, implementation, and documentation, which present difficulties in assessing the clinical significance of the results...
May 7, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29734118/multidose-formulation-of-ready-to-use-177-lu-psma-617-in-a-centralized-radiopharmacy-set-up
#3
Sudipta Chakraborty, K V Vimalnath, Rubel Chakravarty, H D Sarma, Ashutosh Dash
Lutetium-177-labeled PSMA inhibitor has emerged as a promising modality for targeted therapy of prostate carcinoma. A protocol for regular multidose formulation of ready-to-use 177 Lu-PSMA-617 has been developed based on detailed and systematic radiochemical investigations. The formulation meets the requirements of clinical use and can be shipped to nuclear medicine centres for administration up to 4 days from the date of formulation. The reported protocol would be useful toward facilitating widespread clinical utilization of 177 Lu-PSMA-617 in the management of prostate cancer...
April 26, 2018: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29732166/secondary-use-of-electronic-medical-records-for-clinical-research-challenges-and-opportunities
#4
Wen-Wai Yim, Amanda J Wheeler, Catherine Curtin, Todd H Wagner, Tina Hernandez-Boussard
With increasingly ubiquitous electronic medical record (EMR) implementation accelerated by the adoption of the HITECH Act, there is much interest in the secondary use of collected data to improve outcomes and promote personalized medicine. A plethora of research has emerged using EMRs to investigate clinical research questions and assess variations in both treatments and outcomes. However, whether because of genuine complexities of modeling disease physiology or because of practical problems regarding data capture, data accuracy, and data completeness, the state of current EMR research is challenging and gives rise to concerns regarding study accuracy and reproducibility...
March 2018: Convergent Science Physical Oncology
https://www.readbyqxmd.com/read/29718756/healthcare-resource-utilization-and-costs-among-psoriasis-patients-treated-with-biologics-overall-and-by-disease-severity
#5
Mwangi J Murage, Amanda Anderson, Susan A Oliveria, Deborah Casso, Clement K Ojeh, Talia M Muram, Joseph F Merola, Andre B Araujo
AIMS: Describe healthcare resource utilization (HCRU) and costs among biologic-treated psoriasis patients in the US, overall and by disease severity. MATERIALS AND METHODS: IQVIA PharMetrics Plus administrative claims data were linked with Modernizing Medicine Data Services Electronic Health Record data and used to select adult psoriasis patients between 01-Apr-2010 and 31-Dec-2014. Eligible patients were classified by disease severity (mild, moderate, severe) using a hierarchy of available clinical measures...
May 2, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29696101/curriculum-design-and-implementation-of-the-emergency-medicine-chief-resident-incubator
#6
Michael A Gisondi, Adaira Chou, Nikita Joshi, Margaret K Sheehy, Fareen Zaver, Teresa M Chan, Jeffrey Riddell, Derek P Sifford, Michelle Lin
Background Chief residents receive minimal formal training in preparation for their administrative responsibilities. There is a lack of professional development programs specifically designed for chief residents. Objective In 2015, Academic Life in Emergency Medicine designed and implemented an annual, year-long, training program and virtual community of practice for chief residents in emergency medicine (EM). This study describes the curriculum design process and reports measures of learner engagement during the first two cycles of the curriculum...
February 24, 2018: Curēus
https://www.readbyqxmd.com/read/29685065/noninvasive-brain-stimulation-challenges-and-opportunities-for-a-new-clinical-specialty
#7
Aaron D Boes, Michael S Kelly, Nicholas T Trapp, Adam P Stern, Daniel Z Press, Alvaro Pascual-Leone
Noninvasive brain stimulation refers to a set of technologies and techniques with which to modulate the excitability of the brain via transcranial stimulation. Two major modalities of noninvasive brain stimulation are transcranial magnetic stimulation (TMS) and transcranial current stimulation. Six TMS devices now have approved uses by the U.S. Food and Drug Administration and are used in clinical practice: five for treating medication refractory depression and the sixth for presurgical mapping of motor and speech areas...
April 24, 2018: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/29670994/weekend-effects-on-health-outcomes-and-operational-efficiency-in-emergency-admissions-to-general-medicine-services-of-the-central-hospital-of-the-autonomous-province-of-bolzano-italy
#8
C J Wiedermann, M Adami, W Wiedermann
The possibility of higher death rates after admission to hospital during the weekend has been intensively investigated in North America and Northern Europe, while data are almost absent from Southern Europe and other WHOV regions. Increased death rates have not been uniformly confirmed. Differences in hospital care on weekends can vary depending on the reason for hospital admission, place and time. The aim was to verify whether weekend admission from the emergency department to internal medicine services is associated with parameters of operational efficiency in a Northern Italian hospital...
May 2018: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/29666669/-egfr-amplification-induces-sensitivity-to-anti-egfr-therapy-in-pancreatic-acinar-cell-carcinoma
#9
Corentin Richard, Julie Niogret, Romain Boidot, Francois Ghiringhelli
Pancreatic acinar cell carcinoma (PACC) is a rare cancer. When the tumor is metastatic, few therapeutic options are available. Precision medicine using next-generation sequencing is defined by the administration of drugs based on the tumor genetic mutations. The usage of precision medicine for finding new therapeutic options for rare cancers is an emerging field. We have reported here the case of a patient bearing a multitreated metastatic PACC. This patient underwent somatic and constitutional exome analyses...
April 15, 2018: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29623155/emergency-medicine-pharmacist-impact-on-door-to-needle-time-in-patients-with-acute-ischemic-stroke
#10
Joshua S Jacoby, Heather M Draper, Lisa E Dumkow, Muhammad U Farooq, G Robert DeYoung, Kasey L Brandt
Background and Purpose: Decreased door-to-needle (DTN) time with tissue plasminogen activator (tPA) for acute ischemic stroke is associated with improved patient outcomes. Emergency medicine pharmacists (EMPs) can expedite the administration of tPA by assessing patients for contraindications, preparing, and administering tPA. The purpose of this study was to determine the impact of EMPs on DTN times and clinical outcomes in patients with acute ischemic stroke who receive tPA in the emergency department...
April 2018: Neurohospitalist
https://www.readbyqxmd.com/read/29610953/judicial-precedent-based-clinical-practice-guidelines-of-propofol-in-sedative-esthetic-surgery
#11
Duk Hee Lee, Joo Hyun Woo, Seung Eun Hong
BACKGROUND: Propofol is has been widely used for sedation in the field of esthetic surgery because of its favorable pharmacokinetic profile. Propofol sedation-induced side effects are rare. However, when present, they can be serious. The number of malpractice claims associated with propofol sedation has increased in recent years. This study aims to show which procedures lead to the most claims in the field of esthetic surgery through a review of Korean precedents. METHODS: Thirteen precedent cases of propofol sedation in the field of esthetic surgery were collected between 2000 and 2016...
April 2, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29605737/rucaparib-an-emerging-parp-inhibitor-for-treatment-of-recurrent-ovarian-cancer
#12
REVIEW
Angela Musella, Erlisa Bardhi, Claudia Marchetti, Laura Vertechy, Giusy Santangelo, Carolina Sassu, Federica Tomao, Francesco Rech, Renzo D'Amelio, Marco Monti, Innocenza Palaia, Ludovico Muzii, Pierluigi Benedetti Panici
Recently, Poly-ADP-Ribose Polymerase (PARP) inhibitors are one of the most intensively studied group of antiblastic agents for the management of recurrent ovarian cancer. Among this family, Olaparib was the first to be approved by European Medicines Agency as maintenance therapy post-response to platinum-based chemotherapy for recurrent ovarian cancer in women with deleterious BRCA1/2 mutation. Following that, the Food and Drug Administration (FDA) approved Olaparib monotherapy as fourth or later line of treatment in advanced ovarian cancer with deleterious germ-line BRCA1/2 mutation...
March 23, 2018: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29605650/evaluating-the-anti-biofilm-and-antibacterial-effects-of-juglans-regia-l-extracts-against-clinical-isolates-of-pseudomonas-aeruginosa
#13
Samaneh Dolatabadi, Hediyeh Nesari Moghadam, Maasoumeh Mahdavi-Ourtakand
OBJECTIVE: Pseudomonas aeruginosa, an opportunistic pathogen, can cause serious health problems and produces several virulence factors. The most important of these factors is biofilm. Many studies suggest administration of new generation of antibiotics, as P. aeruginosa biofilm has developed high resistance to antimicrobial drugs. Emergence of multidrug resistant (MDR) strains has resulted in screening biofilm inhibitors from natural products or modified from natural compounds. To test this hypothesis, we evaluated the inhibitory effects (antibacterial and antibiofilm) of Juglans regia L...
March 29, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29599397/pharmacology-part-1-introduction-to-pharmaoclogy-and-pharmacodynamics
#14
Geoffrey M Currie
There is an emerging need for greater understanding of pharmacology principles amongst technical staff. Indeed, the responsibility of dose preparation and administration, under any level of supervision, demands foundation understanding of pharmacology. This is true for radiopharmaceuticals, contrast media and pharmaceutical interventions / adjunctive medications. Regulation around the same might suggest a need to embed pharmacology theory in undergraduate education programs and there is a need to disseminate that same foundation understanding to practicing clinicians...
March 29, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/29593190/administration-of-kampo-medicine-through-a-tube-at-an-advanced-critical-care-center
#15
Takahiro Niimura, Yoshito Zamami, Toru Imai, Tsuyoshi Ito, Hidenori Sagara, Hichiya Hiroyuki, Satoru Esumi, Kenshi Takechi, Masaki Imanishi, Toshihiro Koyama, Manabu Amano, Naomi Kurata, Yoshihisa Kitamura, Hironori Nakura, Toshiaki Sendo, Keisuke Ishizawa
n emergency and critical care medical centers, tube administration is employed for patients who have difficulty swallowing oral drugs owing to decreased consciousness or mechanical ventilation. However, tube clogging due to drug injection is a concern. We compared the crushing method with the simple suspension method for the passage of amlodipine, an antihypertensive drug, in combination with rikkunshito, which has been used to treat upper gastrointestinal disorders such as functional dyspepsia and gastroesophageal reflux in emergency and critical care medical centers, to ascertain the effect of Kampo products on the passage of other drugs during tube administration...
2018: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/29576826/the-relative-value-of-education-of-emergency-physicians-in-patient-outcome-a-retrospective-analysis-at-a-single-center-in-developing-india
#16
Shastri Vandana, Singh Shubnum, Kole Tamorish
BACKGROUND: There is a considerable paucity with regards to the research available on the quality and quantity of clinical teaching in the national emergency department (ED) setups. With the onset of the age of modern medicine, the outlook towards to the time worn tradition of triage and detailed medical evaluation must be revoked. Despite the variety of programs being conducted in the country, a comparable entity common to all is patients' clinical outcomes which can be measured using simple parameters which can be easily acquired compiling hospital registry entries...
2018: World Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29568497/progress-and-challenges-in-tb-vaccine-development
#17
REVIEW
Gerald Voss, Danilo Casimiro, Olivier Neyrolles, Ann Williams, Stefan H E Kaufmann, Helen McShane, Mark Hatherill, Helen A Fletcher
The Bacille Calmette Guerin (BCG) vaccine can provide decades of protection against tuberculosis (TB) disease, and although imperfect, BCG is proof that vaccine mediated protection against TB is a possibility. A new TB vaccine is, therefore, an inevitability; the question is how long will it take us to get there? We have made substantial progress in the development of vaccine platforms, in the identification of antigens and of immune correlates of risk of TB disease. We have also standardized animal models to enable head-to-head comparison and selection of candidate TB vaccines for further development...
2018: F1000Research
https://www.readbyqxmd.com/read/29560161/exploring-nurses-experience-about-facilitating-factors-in-medication-administration-based-on-clinical-judgment-of-nurses-a-content-analysis
#18
Jamal Seidi, Fatemeh Alhani, Farasat Ardalan
Background: Clinical judgment of nurses to conduct medication orders is based on patient assessment, medication knowledge, observation, and interpretation of the data collected. This process is influenced by many factors. Objective: This study aims to explore nurses' experience about facilitating factors in medication administration based on clinical judgment of nurses. Methods: This qualitative study was part of an approved project research of the Iranian National Institute of Health Research, which was conducted in Kurdistan University of Medical Sciences in 2015...
December 2017: Electronic Physician
https://www.readbyqxmd.com/read/29559796/rhein-inhibits-malignant-phenotypes-of-human-renal-cell-carcinoma-by-impacting-on-mapk-nf-%C3%AE%C2%BAb-signaling-pathways
#19
Ya-Li Ma, Fang Chen, Jun Shi
Background: Rhein, an anthraquinone derivative of rhubarb, is traditionally used in Chinese herbal medicine. Now emerging studies suggest its antitumor properties in many human cancers. The present study aims to investigate the antitumor role of Rhein and its possible mechanism in human renal cell carcinoma (RCC). Materials and methods: Three RCC cell lines (A489, 786-O and ACHN) were used as the cell models. We applied CCK-8, cell counting, colony formation, wound healing and Transwell assays to assess the antitumor roles of Rhein in RCC cells in vitro...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29557754/arnica-compositum-hekla-lava-and-acidum-nitricum-together-are-superior-to-arnica-compositum-alone-in-the-local-treatment-of-symptomatic-calcific-periarthritis-of-the-shoulder-a-pilot-study
#20
Simone Zanella, Francesco Buccelletti, Francesco Franceschi, Claudio Ramponi, Federica Spagnolli, Gianpaolo Sacchetti, Giovanna Oliva, Franco Lumachi
BACKGROUND: To evaluate the usefulness of Arnica compositum (AC) + Acidum nitricum (AN) + Hekla lava (HL) ointment in Emergency Medicine Department (EMD) as alternative nonpharmacological local treatment of patients with symptomatic calcific periarthritis of the shoulder (CPS) and to compare the effectiveness of this mixture against AC ointment alone. METHODS: A series of 41 consecutive patients (20 women, 19 men, median age 49 years, range 25-80 years) with non-traumatic painful unilateral CPS were randomly assigned to receive local treatment with AC+AN+HL ointment mixture (Group A, cases, N=21) or AC ointment alone (Group B, controls, N=20)...
2018: Reviews on Recent Clinical Trials
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