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https://www.readbyqxmd.com/read/27805562/acute-kidney-injury-in-leptospirosis-the-kidney-disease-improving-global-outcomes-kdigo-criteria-and-mortality%C3%A2
#1
Flávio Teles, Júlia Vanessa de Mendonça Uchôa, Darina Mirelli Barreto Mendonça, André Falcão Pedrosa Costa
Acute kidney injury (AKI) is one of the most serious complications of leptospirosis. In recent years, studies have evaluated this complication using the risk, injury, failure, loss, and end-stage kidney disease and the acute kidney injury network classification systems. More recently, the kidney disease improving global outcomes (KDIGO) criteria have been developed to increase accuracy in detecting AKI. The aim of the present study was to determine the prevalence and factors associated with AKI and mortality in patients with leptospirosis, using KDIGO criteria...
November 2, 2016: Clinical Nephrology
https://www.readbyqxmd.com/read/27683034/intraglomerular-crosstalk-elaborately-regulates-podocyte-injury-and-repair-in-diabetic-patients-insights-from-a-3d-multiscale-modeling-study
#2
Hua Tan, Hualin Yi, Weiling Zhao, Jian-Xing Ma, Yuanyuan Zhang, Xiaobo Zhou
Podocytes are mainly involved in the regulation of glomerular filtration rate (GFR) under physiological condition. Podocyte depletion is a crucial pathological alteration in diabetic nephropathy (DN) and results in a broad spectrum of clinical syndromes such as protein urine and renal insufficiency. Recent studies indicate that depleted podocytes can be regenerated via differentiation of the parietal epithelial cells (PECs), which serve as the local progenitors of podocytes. However, the podocyte regeneration process is regulated by a complicated mechanism of cell-cell interactions and cytokine stimulations, which has been studied in a piecemeal manner rather than systematically...
September 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/27435002/current-anti-myeloma-therapies-in-renal-manifestations-of-monoclonal-light-chain-associated-fanconi-syndrome-a-retrospective-series-of-49-patients
#3
M Vignon, V Javaugue, M P Alexander, K El-Karoui, A Karras, D Roos-Weil, B Royer, B Asli, B Knebelmann, G Touchard, A Jaccard, B Arnulf, F Bridoux, N Leung, J P Fermand
We retrospectively reviewed 49 patients with light-chain (LC) Fanconi syndrome. Patients presented with chronic kidney disease (median estimated glomerular filtration rate (eGFR) of 33 ml/min/m2) and tubular proteinuria. All patients tested had elevated fractional excretion of phosphate, uric acid, generalized aminoaciduria and/or normoglycemic glycosuria. Thirty-eight patients had monoclonal gammopathy of renal significance and 11 patients had an overt hematological malignancy. The monoclonal LC isotype was kappa in 46/49 cases...
July 20, 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/27297907/large-scale-purification-and-in-vitro-characterization-of-the-assembly-of-mreb-from-leptospira-interrogans
#4
Szilvia Barkó, Dávid Szatmári, Emőke Bódis, Katalin Türmer, Zoltán Ujfalusi, David Popp, Robert C Robinson, Miklós Nyitrai
BACKGROUND: Weil's syndrome is caused by Leptospira interrogans infections, a Gram negative bacterium with a distinct thin corkscrew cell shape. The molecular basis for this unusual morphology is unknown. In many bacteria, cell wall synthesis is orchestrated by the actin homolog, MreB. METHODS: Here we have identified the MreB within the L. interrogans genome and expressed the His-tagged protein product of the synthesized gene (Li-MreB) in Escherichia coli. Li-MreB did not purify under standard nucleotide-free conditions used for MreBs from other species, requiring the continual presence of ATP to remain soluble...
September 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27175311/chronic-physical-stress-does-not-interact-with-epstein-barr-virus-ebv-encoded-dutpase-to-alter-the-sickness-response
#5
Taryn G Aubrecht, Zachary M Weil, Bachir Abi Salloum, Maria Eugenia Ariza, Marshall Williams, Brenda Reader, Ronald Glaser, John Sheridan, Randy J Nelson
Most adult humans have been infected with Epstein-Barr virus (EBV), which is thought to contribute to the development of chronic fatigue syndrome. Stress is known to influence the immune system and can exacerbate the sickness response. Although a role for psychological stress in the sickness response, particularly in combination with EBV-encoded deoxyuridine triphosphate nucleotidohydrolase (dUTPase) has been established, and the role of physical stressors in these interactions remains unspecified. In this study, we seek to determine the interaction of chronic physical (swim) stress and EBV-encoded dUTPase injection...
October 2015: Journal of Behavioral and Brain Science
https://www.readbyqxmd.com/read/27080167/a-large-family-of-dscam-genes-with-tandemly-arrayed-5-cassettes-in-chelicerata
#6
Yuan Yue, Yijun Meng, Hongru Ma, Shouqing Hou, Guozheng Cao, Weiling Hong, Yang Shi, Pengjuan Guo, Baoping Liu, Feng Shi, Yun Yang, Yongfeng Jin
Drosophila Dscam1 (Down Syndrome Cell Adhesion Molecules) and vertebrate clustered protocadherins (Pcdhs) are two classic examples of the extraordinary isoform diversity from a single genomic locus. Dscam1 encodes 38,016 distinct isoforms via mutually exclusive splicing in D. melanogaster, while the vertebrate clustered Pcdhs utilize alternative promoters to generate isoform diversity. Here we reveal a shortened Dscam gene family with tandemly arrayed 5' cassettes in Chelicerata. These cassette repeats generally comprise two or four exons, corresponding to variable Immunoglobulin 7 (Ig7) or Ig7-8 domains of Drosophila Dscam1...
2016: Nature Communications
https://www.readbyqxmd.com/read/27021476/-hepatopulmonary-syndrome
#7
Thierry Thévenot, Delphine Weil, Armand Garioud, Hortensia Lison, Jean-François Cadranel, Bruno Degano
Hepatopulmonary syndrome (HPS) is defined by the association of portal hypertension, increased alveolar-arterial oxygen gradient and intrapulmonary vascular dilations. Pathophysiological mechanisms of hypoxemia are characterized by ventilation-perfusion mismatch, oxygen diffusion limitation between alveolus and the centre of the dilated capillary, and right-to-left shunting. An excess of vasodilator molecules (like nitric monoxide) and proangiogenic factors (like VEGF) play an important role in the occurrence of HPS...
May 2016: La Presse Médicale
https://www.readbyqxmd.com/read/26964740/atypical-leptospirosis-an-overlooked-cause-of-aseptic-meningitis
#8
Ning Wang, Yu-Hsuan Han, Jia-Ying Sung, Wen-Sen Lee, Tsong-Yih Ou
BACKGROUND: Leptospirosis, probably the most common zoonosis in the world, is caused by pathogenic Leptospira species. Clinical presentations range from nonspecific fevers to fulminant diseases such as Weil's syndrome. Neurological forms of leptospirosis (neuroleptospirosis) are usually underestimated, and many cases of leptospirosis are overlooked because of the lack of specificity of signs and symptoms. Diagnosis confirmation is difficult because of the challenges associated with isolating the organism and positive serologic testing...
2016: BMC Research Notes
https://www.readbyqxmd.com/read/26790224/-factors-influencing-acupuncture-for-insomnia
#9
Yaping Hai, Weiling Zhagn, Erjun Liu, Shengqiang Wang, Qiang Liu
By analyzing and summarizing the previous research results regarding acupuncture for insomnia, factors influencing the efficacy of acupuncture on insomnia were discussed, and a summary was made from aspects of age, gender, duration of insomnia, use of medication, types of syndrome differentiation, acupoint selection, acupoint combination, acupuncture timing, etc. With respect to the influencing factors, precautions during the clinical syndrome differentiation were briefly reviewed, and the treatment plan of acupuncture for insomnia was optimized, which could provide new methods and thoughts for clinical and scientific research regarding acupuncture for insomnia...
October 2015: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/26595349/indoleamine-hallucinogens-in-cluster-headache-results-of-the-clusterbusters-medication-use-survey
#10
Emmanuelle A D Schindler, Christopher H Gottschalk, Marsha J Weil, Robert E Shapiro, Douglas A Wright, Richard Andrew Sewell
Cluster headache is one of the most debilitating pain syndromes. A significant number of patients are refractory to conventional therapies. The Clusterbusters.org medication use survey sought to characterize the effects of both conventional and alternative medications used in cluster headache. Participants were recruited from cluster headache websites and headache clinics. The final analysis included responses from 496 participants. The survey was modeled after previously published surveys and was available online...
November 2015: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/26587805/second-nordic-congress-on-obesity-in-gynecology-and-obstetrics-nocogo
#11
Christina A Vinter, Britta Frederiksen-Møller, Louise K Weile, Ronald F Lamont, Bjarne R Kristensen, Jan S Jørgensen
No abstract text is available yet for this article.
January 2016: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/26554032/long-range-rna-pairings-contribute-to-mutually-exclusive-splicing
#12
Yuan Yue, Yun Yang, Lanzhi Dai, Guozheng Cao, Ran Chen, Weiling Hong, Baoping Liu, Yang Shi, Yijun Meng, Feng Shi, Mu Xiao, Yongfeng Jin
Mutually exclusive splicing is an important means of increasing the protein repertoire, by which the Down's syndrome cell adhesion molecule (Dscam) gene potentially generates 38,016 different isoforms in Drosophila melanogaster. However, the regulatory mechanisms remain obscure due to the complexity of the Dscam exon cluster. Here, we reveal a molecular model for the regulation of the mutually exclusive splicing of the serpent pre-mRNA based on competition between upstream and downstream RNA pairings. Such dual RNA pairings confer fine tuning of the inclusion of alternative exons...
January 2016: RNA
https://www.readbyqxmd.com/read/26261162/leptospirosis-among-the-self-supporting-convicts-of-andaman-island-during-the-1920s-the-first-report-on-pulmonary-haemorrhage-in-leptospirosis
#13
REVIEW
P Vijayachari, A P Sugunan, S S Singh, P P Mathur
Several researchers had carried out investigations on the possibility of existence of Weil's disease in Andaman Islands during early 20 th century. The first report of a series of confirmed cases of leptospirosis that occurred during 1929 was published in 1931.There were several reports during 1995 to 2009 that described detailed account of leptospirosis including various clinical syndromes. The possibility of pulmonary involvement in leptospirosis being a manifestation historically overlooked rather than newly emerged during the past two decades is examined in this review in the context of Andaman Islands...
July 2015: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/26256942/management-of-myelodysplastic-syndrome-relapsing-after-allogeneic-hematopoietic-stem-cell-transplantation-a-study-by-the-french-society-of-bone-marrow-transplantation-and-cell%C3%A2-therapies
#14
Romain Guièze, Gandhi Damaj, Bruno Pereira, Marie Robin, Patrice Chevallier, Mauricette Michallet, Stéphane Vigouroux, Yves Beguin, Didier Blaise, Jean El Cheikh, Damien Roos-Weil, Anne Thiebaut, Pierre-Simon Rohrlich, Anne Huynh, Jérôme Cornillon, Nathalie Contentin, Felipe Suarez, Bruno Lioure, Mohamad Mohty, Natacha Maillard, Laurence Clement, Sylvie François, Gaëlle Guillerm, Ibrahim Yakoub-Agha
To find out prognostic factors and to investigate different therapeutic approaches, we report on 147 consecutive patients who relapsed after allogeneic hematopoietic stem cell transplantation (allo-HSCT) for myelodysplastic syndrome (MDS). Sixty-two patients underwent immunotherapy (IT group, second allo-HSCT or donor lymphocyte infusion), 39 received cytoreductive treatment alone (CRT group) and 46 were managed with palliative/supportive cares (PSC group). Two-year rates of overall survival (OS) were 32%, 6%, and 2% in the IT, CRT, and PSC groups, respectively (P < ...
February 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/26121435/pituitary-mri-findings-in-patients-with-pituitary-and-ectopic-acth-dependent-cushing-syndrome-does-a-6-mm-pituitary-tumor-size-cut-off-value-exclude-ectopic-acth-syndrome
#15
Divya Yogi-Morren, Mouhammed Amir Habra, Charles Faiman, James Bena, Betul Hatipoglu, Laurence Kennedy, Robert J Weil, Amir H Hamrahian
OBJECTIVE: Expert opinion and a consensus statement on Cushing syndrome (CS) indicate that in a patient with a clinical presentation and biochemical studies consistent with a pituitary etiology, the presence of a pituitary tumor ≥6 mm is highly suggestive of Cushing disease (CD). The purpose of the present study was to determine the optimal pituitary tumor size that can differentiate between patients with CD and ectopic adrenocorticotrophic hormone (ACTH) secretion (EAS) and obviate the need for inferior petrosal sinus sampling (IPSS)...
October 2015: Endocrine Practice
https://www.readbyqxmd.com/read/26053963/treatment-of-a-cerebral-pial-arteriovenous-fistula-in-a-patient-with-sickle-cell-disease-related-moyamoya-syndrome-case-report
#16
Anna Lo Presti, Alexander G Weil, Aria Fallah, Eric C Peterson, Toba N Niazi, Sanjiv Bhatia
Sickle cell disease (SCD) is an autosomal recessive hematological disorder, characterized by sickling of the red blood cells in response to a hypoxic stress and vaso-occlusive crises. It is associated with moyamoya-like changes on cerebral angiographic imaging in 43% of patients. Cerebral aneurysms, arteriovenous malformations, and dural arteriovenous fistulas (AVFs) have been described in association with SCD and moyamoya disease. However, the description of a pial AVF (pAVF) in a patient with SCD and/or moyamoya formation has not yet been reported...
August 2015: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/25987479/severe-leptospirosis-complicated-by-epstein-barr-virus-reactivation
#17
Matthias Karrasch, Konstantin Herfurth, Monika Kläver, Jenny Miethke, Anne Mayer-Scholl, Enno Luge, Eberhard Straube, Martin Busch
INTRODUCTION: Weil's disease is a severe, potentially fatal illness following Leptospira interrogans infection. The reported case of a patient suffering from acute renal failure, jaundice, thrombocytopenia, rhabdomyolysis and encephalitis syndrome highlights the clinical challenge in reference to Weil syndrome complicated by Epstein-Barr Virus (EBV) reactivation. MATERIALS AND METHODS: The diagnosis of leptospirosis was performed using four different diagnostic methods...
December 2015: Infection
https://www.readbyqxmd.com/read/25971214/pharmacist-collaborative-practice-agreement-for-the-management-of-anemia-in-malignant-disease-with-erythropoiesis-stimulating-agents
#18
MULTICENTER STUDY
Elizabeth Weil, Carolyn Oxencis
PURPOSE: Erythropoiesis-stimulating agents (ESAs) reduce transfusions and increase hemoglobin levels in patients with anemia of malignant disease. A medication guideline and pharmacist collaborative practice agreement (CPA) were developed and implemented to standardize ESA prescribing workflow. The use of ESAs in malignant diseases, in accordance with institutional guidelines, was evaluated to ensure safe and effacious use. METHODS: An observational study was conducted on all ESA doses given throughout a health system's cancer clinics prior to and after implementation of an ESA guideline and pharmacist CPA...
August 2015: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/25883839/herpes-simplex-reactivation-or-postinfectious-inflammatory-response-after-epilepsy-surgery-case-report-and-review-of-the-literature
#19
Anna Lo Presti, Alexander G Weil, Toba N Niazi, Sanjiv Bhatia
BACKGROUND: Herpes simplex virus encephalitis (HSVE) is the most morbid clinical syndrome associated with the human herpes virus. Despite treatment with appropriate dosages of acyclovir, neurologic relapse of HSV infection have been reported after cranial surgery. Rarely, neurological deterioration due to postinfectious inflammatory response without demonstrable HSV reactivation may recur following cranial surgery. CASE DESCRIPTION: We report a case of a 17-year-old girl who presented with a HSVE relapse on the 6(th) postoperative day following resective surgery for medically refractory epilepsy and review the literature...
2015: Surgical Neurology International
https://www.readbyqxmd.com/read/25859986/monitoring-anticoagulant-therapy-with-vitamin-k-antagonists-in-patients-with-antiphospholipid-syndrome
#20
Mecki Isert, Wolfgang Miesbach, Gundolf Schüttfort, Yvonne Weil, Vanessa Tirneci, Alexander Kasper, Adele Weber, Edelgard Lindhoff-Last, Eva Herrmann, Birgit Linnemann
Because of the possible interference of antiphospholipid antibodies (APL) with the phospholipid component of thromboplastin reagents, concerns have been raised about the validity of international normalized ratio (INR) testing to monitor anticoagulant therapy with vitamin K antagonists in patients with antiphospholipid syndrome (APS). To investigate the reliability of the INR, we determined the INR using various prothrombin time (PT) assays and compared the results with those of a chromogenic factor X (CFX) assay...
August 2015: Annals of Hematology
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