keyword
MENU ▼
Read by QxMD icon Read
search

Voltaren gel

keyword
https://www.readbyqxmd.com/read/27887033/skin-irritation-and-sensitization-potential-of-fixed-dose-combination-of-diclofenac-1-and-menthol-3-topical-gel-results-of-two-phase-i-patch-studies
#1
D Jeffery Liu, A Collaku, J S Dosik
Phase I, randomized, controlled patch studies were conducted to evaluate skin sensitization and irritation potential of a new gel formulation containing 1% diclofenac and 3% menthol as a fixed-combination product.In study A, healthy volunteers were exposed to 4 test patches containing 1% diclofenac+3% menthol, diclofenac, menthol, or placebo gels during an induction (nine 48 to 72-h applications) and challenge phase (one 48-h application). Some subjects were re-challenged to evaluate suspected sensitization...
November 25, 2016: Drug Research
https://www.readbyqxmd.com/read/27789369/gellan-gum-fluid-gels-for-topical-administration-of-diclofenac
#2
Mohammed H Mahdi, Barbara R Conway, Thomas Mills, Alan M Smith
Diclofenac topical formulations are often preferred for drug administration to patients who experience serious GIT problems. Absorption of the drug through the skin, however, can be challenging due to the natural protective feature of the stratum corneum (SC). In this article, fluid gels prepared from gellan gum were explored as a topical drug delivery vehicle. Rheological analysis of the formulations showed that it was possible to produce a topical gel with a viscosity and the mechanical strength similar to that of the commercially available Voltaren(®) gel using 1% w/w of a 50:50 low acyl/high acyl (LA/HA) gellan blend...
December 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27593184/self-assembling-organogels-based-on-pluronic-and-lethicin-for-sustained-release-of-etodolac-in-vitro-and-in-vivo-correlation
#3
Ahmed M Mohammed, W Faisal, Khaled I Saleh, Shaaban K Osman
Etodolac, a member of non steroidal anti-inflammatory drugs (NSAIDs), has a poor aqueous solubility. Long term administration of etodolac causes severe gastrointestinal disturbances such as peptic ulcer and bleeding. These disturbances could be overcome by alternative routes such as a topical administration. In the present study, pluronic lecithin organogels (PLOs) were prepared by simple mixing of pluronic solution with lecithin solution. Etodolac was loaded into the prepared gels or added during the gel formation...
September 2, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/26827543/-the-antalgic-and-antiphiogistic-function-and-mechanism-of-rgdt-plaster
#4
Xiao-Xia Liu, Zhi-wang Wang, Xiao-pin Chien, Cai-min Liu, Hai-yan Tuo
OBJECTIVE: To study the antalgic and antiphlogistic functions and mechanism of ronggudingtong (RGDT) plaster (traditional Chinese medicine). METHODS: The painful models were established with hot plate test or acetic acid writhing and the inflammatory models were established with daubing dimethylbenzene on auricle or injecting formaldehyde in toe or synovial envelope to study the antalgic and antiphlogistic functions of RGDT Plaster. The total protein and leukotriene B4(LTB4) in inflammatory exudate were detected to investigate the antalgic and antiphlogistic mechanism of RGDT plaster...
September 2015: Chinese Journal of Applied Physiology
https://www.readbyqxmd.com/read/26352120/retrospective-evaluation-on-the-analgesic-activities-of-2-compounded-topical-creams-and-voltaren-gel-in-chronic-noncancer-pain
#5
John C Somberg, Janos Molnar
Pharmacologic treatment of chronic pain is challenging. Oral therapy may require multiple medications; each has side effects, dose limitations, and limited efficacy. Compounded topical formulations have evolved as potential treatment options. The objective of this study was to evaluate the efficacy of 2 compounded topical creams, "Cream I" and "Cream II," in patients with chronic extremity, joint, musculoskeletal, neuropathic, or other chronic topical pain conditions and compare their efficacy with Voltaren gel...
September 2015: American Journal of Therapeutics
https://www.readbyqxmd.com/read/25758411/effect-of-microporation-on-passive-and-iontophoretic-delivery-of-diclofenac-sodium
#6
Hiren Patel, Abhay Joshi, Amit Joshi, Grazia Stagni
Skin pretreatment with a microneedle roller (microporation (MP)) appears a simple and inexpensive technique to increase transdermal delivery of topically applied drug products. This study investigates the effect of MP on the passive and iontophoretic delivery of diclofenac (DCF) by quantifying dermis and plasma levels of DCF in a rabbit model. New Zealand albino female rabbits received either: (i) a topical application of 4 g of Voltaren® 1% gel with or without pretreatment with a microroller (0.5 mm needle length; density 23 microneedles per cm(2) area) or (ii) a DCF solution (40 mg/2...
2015: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/25415787/development-of-an-effective-topical-liposomal-formulation-for-localized-analgesia-and-anti-inflammatory-actions-in-the-complete-freund-s-adjuvant-rodent-model-of-acute-inflammatory-pain
#7
RANDOMIZED CONTROLLED TRIAL
Katerina S Iwaszkiewicz, Susan Hua
BACKGROUND: Peripheral opioid receptor targeting has been well established as a novel target in clinical pain management for acute and chronic peripheral inflammatory pain. The physiochemical properties of the peripheral mu-opioid receptor agonist, loperamide HCl, limit the use of the free drug as an analgesic or anti-inflammatory agent, particularly for dermal delivery across intact skin. OBJECTIVE: Our objective was to manufacture an effective topical formulation containing loperamide using liposomal delivery that would allow loperamide to produce analgesia and anti-inflammatory effects, by penetrating the epidermis to reach peripheral opioid receptors within the dermis of intact skin...
November 2014: Pain Physician
https://www.readbyqxmd.com/read/24601219/comparison-of-skin-permeability-for-three-diclofenac-topical-formulations-an-in-vitro-study
#8
COMPARATIVE STUDY
E Folzer, D Gonzalez, R Singh, H Derendorf
Diclofenac is a hydrophilic non-steroidal anti-inflammatory drug (NSAID) widely used in humans and animals. There are limited published studies evaluating diclofenac's skin permeation following topical administration. The aim of our study was to evaluate and compare the in vitro permeation of three different diclofenac-containing formulations (patch, gel, solution) over 24 hours. These formulations were applied (n = 6 per formulation) to pig skin sandwiched between the two chambers in a static Franz diffusion cell and aliquots from the receptor medium were sampled at pre-defined time points...
January 2014: Die Pharmazie
https://www.readbyqxmd.com/read/24373109/topical-nsaid-formulations
#9
REVIEW
Mary Lynn McPherson, Nina M Cimino
OBJECTIVE: This article reviews topical nonsteroidal anti-inflammatory drug (NSAID) formulations available in the United States, including advantages and disadvantages, therapeutic usefulness, adverse effects, and formulation considerations. RESULTS: In the United States, several topical NSAID products are approved to treat painful conditions including diclofenac sodium 1% gel (Voltaren Gel®; Endo Pharmaceuticals), diclofenac sodium topical solution 1.5% w/w in 45...
December 2013: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/24011150/-therapeutic-effect-and-hepatotoxicity-of-tripterygium-wilfordii-compound-recipe-gel-on-adjuvant-induced-arthritis-rat
#10
Jie Zhou, Yuefeng Liu, Kai He
OBJECTIVE: To investigate the therapeutic effect and the impact on liver function of different-dose Tripterygium wilfordii compound recipe gel (TWCG) for external use on adjuvant-induced arthritis (AA) rats. METHODS: Freund's adjuvant-induced arthritis rats were dressed with different doses of TWCG, voltaren as positive control and blank gel as blank control. The ankle swelling degrees were evaluated; the serum levels of tumor necrosis factor-α (TNF-α) and interleukin-4 (IL-4) were detected by ELISA; the levels of matrix metalloproteinase-3 (MMP-3) in ankle cartilage were determined by immunohistochemical method; the serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were tested with the automatic biochemical analyzer...
September 2013: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/22092669/skin-hydration-and-cooling-effect-produced-by-the-voltaren%C3%A2-vehicle-gel
#11
Agnes M Hug, Thomas Schmidts, Jens Kuhlmann, Dörte Segger, Grigorios Fotopoulos, Johanna Heinzerling
BACKGROUND: Voltaren vehicle gel is the carrier substance of the topical Voltaren products. This vehicle gel is especially formulated to be easily applied on the skin, while providing some sensory benefits. The present study aims to substantiate the widely perceived hydrating and cooling effect of Voltaren vehicle gel. METHODS: Volar forearm skin hydration and transepidermal water loss (TEWL) were measured and user satisfaction was evaluated by questionnaires, after application in 31 healthy, female volunteers...
May 2012: Skin Research and Technology
https://www.readbyqxmd.com/read/21241352/a-new-topical-formulation-enhances-relative-diclofenac-bioavailability-in-healthy-male-subjects
#12
RANDOMIZED CONTROLLED TRIAL
Martin Brunner, David Davies, Wolfgang Martin, Chiara Leuratti, Edith Lackner, Markus Müller
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT: • Therapy with topical non-steroidal anti-inflammatory drugs (NSAIDs) relies on the ability of the active drug to penetrate the skin in sufficiently high amounts to exert a clinical effect, which is linked to the specific galenic properties of the formulation. WHAT THIS STUDY ADDS: • This phase 1 study characterizes the transdermal penetration and plasma exposure of different dose levels with galenic differences of a novel topical diclofenac formulation under development and indicates greater diclofenac penetration through the skin when compared with a commercially available formulation...
June 2011: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/20854305/a-comparative-subjective-assessment-study-of-pennsaid%C3%A2-and-voltaren-gel%C3%A2-two-topical-formulations-of-diclofenac-sodium
#13
RANDOMIZED CONTROLLED TRIAL
Bradley S Galer
Osteoarthritis (OA) is a chronic degenerative joint disease that is debilitating for many individuals. While oral nonsteroidal anti-inflammatory drugs (NSAIDs) remain a common and effective treatment approach to managing OA, concerns over cardiovascular and gastrointestinal adverse events can potentially limit their use. Various formulations of topical NSAIDs have been shown to provide effective localized treatment with minimal adverse events. A patient perception study was conducted to evaluate patient preference between topical diclofenac sodium gel and that of diclofenac sodium topical solution with the penetration enhancer dimethyl sulfoxide (DMSO)...
May 2011: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/19648310/diclofenac-sodium-gel-in-patients-with-primary-hand-osteoarthritis-a-randomized-double-blind-placebo-controlled-trial
#14
RANDOMIZED CONTROLLED TRIAL
Roy D Altman, Renée-Liliane Dreiser, Chester L Fisher, Walter F Chase, Donatus S Dreher, Josef Zacher
OBJECTIVE: To measure the efficacy and safety of diclofenac sodium gel in patients with primary hand osteoarthritis (OA). METHODS: In a randomized, double-blind, placebo-controlled trial, men and women aged > or = 40 years diagnosed with primary OA in the dominant hand were randomly assigned to self-apply topical 1% diclofenac sodium gel (Voltaren Gel) (n = 198) or vehicle (n = 187) to both hands 4 times daily for 8 weeks. Primary outcome measures included OA pain intensity (100-mm visual analog scale), total Australian/Canadian Osteoarthritis Hand Index (AUSCAN) score, and global rating of disease activity at 4 and 6 weeks...
September 2009: Journal of Rheumatology
https://www.readbyqxmd.com/read/19418961/effect-of-vehicle-on-diclofenac-sodium-permeation-from-new-topical-formulations-in-vitro-and-in-vivo-studies
#15
Vanna Sanna, Alessandra T Peana, Mario D L Moretti
In this study the effect of vehicle on in vitro diffusion of diclofenac sodium (DS) from new different formulations such as Carbopol gel (A), Sodium lauryl sulphate cream (B) and Carbopol cream (C) was evaluated with Franz diffusion cells using hydrophilic and hydrophobic synthetic membranes. The commercial formulation Voltaren Emulgel was used as reference. Furthermore, the in vivo efficacy of topical formulations was studied in the carrageenan-induced edema and hyperalgesia, whereas the antinociceptive effect was evaluated on thermal pain threshold in rat paw...
January 2009: Current Drug Delivery
https://www.readbyqxmd.com/read/19332972/topical-therapy-for-osteoarthritis-clinical-and-pharmacologic-perspectives
#16
REVIEW
Roy Altman, Robert L Barkin
Nonsteroidal anti-inflammatory drugs (NSAIDs) have shown efficacy in patients with osteoarthritis (OA) pain but are also associated with a dose-dependent risk of gastrointestinal, cardiovascular, hematologic, hepatic, and renal adverse events (AEs). Topical NSAIDs were developed to provide analgesia similar to their oral counterparts with less systemic exposure and fewer serious AEs. Topical NSAIDs have long been available in Europe for the management of OA, and guidelines of the European League Against Rheumatism and the Osteoarthritis Research Society International specify that topical NSAIDs are preferred over oral NSAIDs for patients with knee or hand OA of mild-to-moderate severity, few affected joints, and/or a history of sensitivity to oral NSAIDs...
March 2009: Postgraduate Medicine
https://www.readbyqxmd.com/read/19207508/treating-osteoarthritis-topically-voltaren-gel-for-pain-relief
#17
Sue A Woodson
No abstract text is available yet for this article.
February 2009: Nursing for Women's Health
https://www.readbyqxmd.com/read/18814824/review-of-the-pharmaceutical-properties-and-clinical-effects-of-the-topical-nsaid-formulation-diclofenac-epolamine
#18
REVIEW
K D Rainsford, W F Kean, G E Ehrlich
BACKGROUND: Topical formulations of non-steroidal anti-inflammatory drugs (NSAIDs), in particular diclofenac (DI), have become popular for treating various acute and chronic painful inflammatory conditions. OBJECTIVE: To perform a literature review of (1) the use of topical NSAIDs; (2) the pharmaceutical, pharmacokinetic and pharmacodynamic properties of a medicated plaster (patch) containing diclofenac epolamine (DI-EP, Flector Tissugel, Flector patch) compared with other formulations of topical NSAIDs; and (3) evaluation of the clinical findings from studies with this novel DI-EP patch...
October 2008: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/16431047/transdermal-drug-delivery-using-microemulsion-and-aqueous-systems-influence-of-skin-storage-conditions-on-the-in-vitro-permeability-of-diclofenac-from-aqueous-vehicle-systems
#19
COMPARATIVE STUDY
Amnon C Sintov, Shafir Botner
The objective of this study was to evaluate the transdermal delivery potential of diclofenac-containing microemulsion system in vivo and in vitro. It was found that the transdermal administration of the microemulsion to rats resulted in 8-fold higher drug plasma levels than those obtained after application of Voltaren Emulgel. After s.c. administration (3.5 mg/kg), the plasma levels of diclofenac reached a peak of 0.94 microg/ml at t=1 h and decreased rapidly to 0.19 microg/ml at t=6 h, while transdermal administration of the drug in microemulsion maintained constant levels of 0...
March 27, 2006: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/16236050/favourable-dermal-penetration-of-diclofenac-after-administration-to-the-skin-using-a-novel-spray-gel-formulation
#20
COMPARATIVE STUDY
Martin Brunner, Pejman Dehghanyar, Bernd Seigfried, Wolfgang Martin, Georg Menke, Markus Müller
AIMS: The study was designed to evaluate the relative bioavailability of diclofenac in plasma, subcutaneous adipose and skeletal muscle tissue after repeated topical administration using MIKA Diclofenac Spray Gel (4%), a novel formulation, and after oral dosing using VOLTAREN 50 mg enteric coated tablets. METHODS: Diclofenac (48 mg) was administered topically three times daily for 3 days onto a defined area of the thigh of 12 healthy males. After a 14-day wash out period, subjects were orally treated with 50 mg diclofenac three times daily for 3 days...
November 2005: British Journal of Clinical Pharmacology
keyword
keyword
114022
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"