keyword
https://read.qxmd.com/read/38189684/low-cost-biosensor-technologies-for-rapid-detection-of-covid-19-and-future-pandemics
#21
REVIEW
William Reis de Araujo, Heather Lukas, Marcelo D T Torres, Wei Gao, Cesar de la Fuente-Nunez
Many systems have been designed for the detection of SARS-CoV-2, which is the virus that causes COVID-19. SARS-CoV-2 is readily transmitted, resulting in the rapid spread of disease in human populations. Frequent testing at the point of care (POC) is a key aspect for controlling outbreaks caused by SARS-CoV-2 and other emerging pathogens, as the early identification of infected individuals can then be followed by appropriate measures of isolation or treatment, maximizing the chances of recovery and preventing infectious spread...
January 8, 2024: ACS Nano
https://read.qxmd.com/read/38182954/smart-carbon-based-sensors-for-the-detection-of-non-coding-rnas-associated-with-exposure-to-micro-nano-plastics-an-artificial-intelligence-perspective
#22
REVIEW
Pooja Ratre, Nazim Nazeer, Nikita Soni, Prasan Kaur, Rajnarayan Tiwari, Pradyumna Kumar Mishra
Micro(nano)plastics (MNPs) are pervasive environmental pollutants that individuals eventually consume. Despite this, little is known about MNP's impact on public health. In this article, we assess the evidence for potentially harmful consequences of MNPs in the human body, concentrating on molecular toxicity and exposure routes. Since MNPs are present in various consumer products, foodstuffs, and the air we breathe, exposure can occur through ingestion, inhalation, and skin contact. MNPs exposure can cause mitochondrial oxidative stress, inflammatory lesions, and epigenetic modifications, releasing specific non-coding RNAs in circulation, which can be detected to diagnose non-communicable diseases...
January 5, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38167964/introducing-a-portable-electrochemical-biosensor-for-mycobacterium-avium-subsp-paratuberculosis-detection-using-graphene-oxide-and-chitosan
#23
JOURNAL ARTICLE
Nahid Naghshgar, Saied Hosseinzadeh, Abdollah Derakhshandeh, Ruhollah Shaali, Mohammad Mahdi Doroodmand
In this contribution, a novel, low-cost, high throughput, and ultra-selective electrochemical DNA nanobiosensor was developed for accurate on-site detection of Mycobacterium avium subspecies paratuberculosis (MAP) in real media for practical diagnosis of Johne's disease (JD). The method was designed based on the immobilization of graphene oxide and chitosan biopolymer on the surface of a glassy carbon electrode, modified by electrochemical immobilization of graphene oxide and chitosan biopolymer, followed by activation of biopolymer via 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride and N-hydroxy succinimide (EDC/NHS) coupling system...
January 2, 2024: Scientific Reports
https://read.qxmd.com/read/38160432/impedance-nanobiosensor-based-on-enzyme-conjugated-biosynthesized-gold-nanoparticles-for-the-detection-of-gram-positive-bacteria
#24
JOURNAL ARTICLE
Sarani Sen, Priyabrata Sarkar
In this report, gold nanoparticles (GNPS) were synthesized using cell-free extracts of seven different isolates, namely, Pseudomonas aerogenosa CEBP2, Pseudomonas sp. CEBP1, Pseudomonas pseudoalcaligenes CEB1G, Acinetobactor baumani CEBS1, Cuprividus sp. CEB3, Micrococcus luteus CUB12, and Pandoraea sp. CUB2S. The spectroscopic (UV-vis, FTIR, DLS, XRD, EDS) and microscopic (FESEM, TEM) results confirm the reduction of Au3+ to Au0 in the presence of biomolecules having reducing as well as self-stabilizing activity...
December 31, 2023: Biotechnology Progress
https://read.qxmd.com/read/38151088/goat-anti-mouse-immunoglobulin-as-crosslinker-assisted-signal-tracer-assemble-with-intensive-antibody-utilization-efficiency-for-sensitive-paper-based-strip-nanobiosensors
#25
JOURNAL ARTICLE
Sijie Liu, Rui Shu, Mingrui Zhang, Cong Zhao, Kexin Wang, Jiayi Zhang, Jing Sun, Leina Dou, Daohong Zhang, Jianlong Wang
Engineered collaborative biochemical techniques and regulated nanomaterials (NMs) offer extraordinary opportunities for improving the analysis performance of lateral flow immunoassay (LFIA). Herein, inspired by the ability of macromolecules (e.g., proteins) to assemble into new functional units and the remarkable optical performance of engineered regulated NMs, goat anti-mouse immunoglobulin (GAMI) serves as the "crosslinker" to integrate gold‑manganese oxide (Au-MnOx ) to assemble the "signal tracers (STs)-crosslinker-antibody (mAb)" for elevating the mAb utilization efficiency...
December 25, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38146466/sensitization-strategies-of-lateral-flow-immunochromatography-for-gold-modified-nanomaterials-in-biosensor-development
#26
REVIEW
Xingyue He, Tianjiao Hao, Hongxu Geng, Shengzhou Li, Chuanjiang Ran, Meirong Huo, Yan Shen
Gold nanomaterials have become very attractive nanomaterials for biomedical research due to their unique physical and chemical properties, including size dependent optical, magnetic and catalytic properties, surface plasmon resonance (SPR), biological affinity and structural suitability. The performance of biosensing and biodiagnosis can be significantly improved in sensitivity, specificity, speed, contrast, resolution and so on by utilizing multiple optical properties of different gold nanostructures. Lateral flow immunochromatographic assay (LFIA) based on gold nanoparticles (GNPs) has the advantages of simple, fast operation, stable technology, and low cost, making it one of the most widely used in vitro diagnostics (IVDs)...
2023: International Journal of Nanomedicine
https://read.qxmd.com/read/38128552/localized-measurements-of-water-potential-reveal-large-loss-of-conductance-in-living-tissues-of-maize-leaves
#27
JOURNAL ARTICLE
Piyush Jain, Annika E Huber, Fulton E Rockwell, Sabyasachi Sen, Noel Michele Holbrook, Abraham D Stroock
The water status of the living tissue in leaves between the xylem and stomata (outside xylem zone - OXZ) plays a critical role for plant function and global mass and energy balance but has remained largely inaccessible. We resolve the local water relations of OXZ tissue using a nanogel reporter of water potential (ψ), AquaDust, that enables an in-situ, non-destructive measurement of both ψ of xylem and highly localized ψ at the terminus of transpiration in the OXZ. Working in maize (Zea mays L...
December 21, 2023: Plant Physiology
https://read.qxmd.com/read/38094845/retracted-construction-and-signal-feature-processing-of-gold-nanobiosensors-based-on-the-internet-of-things
#28
Journal Of Healthcare Engineering
[This retracts the article DOI: 10.1155/2022/1432266.].
2023: Journal of Healthcare Engineering
https://read.qxmd.com/read/38063784/electrochemical-paper-based-nanobiosensor-for-rapid-and-sensitive-detection-of-monkeypox-virus
#29
JOURNAL ARTICLE
Lucas F de Lima, Priscilla P Barbosa, Camila L Simeoni, Rosemeire F de O de Paula, José Luiz Proenca-Modena, William R de Araujo
Monkeypox virus (MPXV) infection was classified as a public health emergency of international concern by the World Health Organization (WHO) in 2022, being transmitted between humans by large respiratory droplets, in contact with skin lesions, fomites, and sexually. Currently, there are no available accessible and simple-to-use diagnostic tests that accurately detect MPXV antigens for decentralized and frequent testing. Here, we report an electrochemical biosensor to detect MPXV antigens in saliva and plasma samples within 15 min using accessible materials...
December 8, 2023: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38024747/nanotechnology-based-strategies-in-parasitic-disease-management-from-prevention-to-diagnosis-and-treatment
#30
REVIEW
Rahul Tiwari, Rohit P Gupta, Vishal K Singh, Awnish Kumar, Rajneesh, Prasoon Madhukar, Shyam Sundar, Vibhav Gautam, Rajiv Kumar
Parasitic infections are a major global health issue causing significant mortality and morbidity. Despite substantial advances in the diagnostics and treatment of these diseases, the currently available options fall far short of expectations. From diagnosis and treatment to prevention and control, nanotechnology-based techniques show promise as an alternative approach. Nanoparticles can be designed with specific properties to target parasites and deliver antiparasitic medications and vaccines. Nanoparticles such as liposomes, nanosuspensions, polymer-based nanoparticles, and solid lipid nanoparticles have been shown to overcome limitations such as limited bioavailability, poor cellular permeability, nonspecific distribution, and rapid drug elimination from the body...
November 14, 2023: ACS Omega
https://read.qxmd.com/read/38007056/microrna-biosensors-in-lung-cancer
#31
REVIEW
Donya Shaterabadi, Maryam Zamani Sani, Fereshteh Rahdan, Mohammad Taghizadeh, Maedeh Rafiee, Nafiseh Dorosti, Aria Dianatinasab, Mortaza Taheri-Anganeh, Peyman Asadi, Seyyed Hossein Khatami, Ahmad Movahedpour
Lung cancer has been one of the leading causes of death over the past century. Unfortunately, the reliance on conventional methods to diagnose the phenotypic properties of tumors hinders early-stage cancer diagnosis. However, recent advancements in identifying disease-specific nucleotide biomarkers, particularly microRNAs, have brought us closer to early-stage detection. The roles of miR-155, miR-197, and miR-182 have been established in stage I lung cancer. Recent progress in synthesizing nanomaterials with higher conductivity has enhanced the diagnostic sensitivity of electrochemical biosensors, which can detect low concentrations of targeted biomarkers...
November 23, 2023: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://read.qxmd.com/read/38005191/recent-advances-in-dietary-sources-health-benefits-emerging-encapsulation-methods-food-fortification-and-new-sensor-based-monitoring-of-vitamin-b-12-a-critical-review
#32
REVIEW
Seyed Mohammad Taghi Gharibzahedi, Maryam Moghadam, Jonas Amft, Aysu Tolun, Gauri Hasabnis, Zeynep Altintas
In this overview, the latest achievements in dietary origins, absorption mechanism, bioavailability assay, health advantages, cutting-edge encapsulation techniques, fortification approaches, and innovative highly sensitive sensor-based detection methods of vitamin B12 (VB12 ) were addressed. The cobalt-centered vitamin B is mainly found in animal products, posing challenges for strict vegetarians and vegans. Its bioavailability is highly influenced by intrinsic factor, absorption in the ileum, and liver reabsorption...
November 7, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/37999613/challenges-and-prospective-of-enhancing-hydatid-cyst-chemotherapy-by-nanotechnology-and-the-future-of-nanobiosensors-for-diagnosis
#33
REVIEW
Soheil Sadr, Narges Lotfalizadeh, Amir Mohammad Abbasi, Nooshinmehr Soleymani, Ashkan Hajjafari, Elahe Roohbaksh Amooli Moghadam, Hassan Borji
Hydatid cysts have been widely recognized for decades as a common medical problem that affects millions of people. A revolution in medical treatment may be on the prospect of nanotechnology enhancing chemotherapy against hydatid cysts. An overview of nanotechnology's impact on chemotherapeutics is presented in the current review. It discusses some of the challenges as well as some of the opportunities. The application of nanotechnology to enhance chemotherapy against hydatid cysts is what this review will explore...
November 6, 2023: Tropical Medicine and Infectious Disease
https://read.qxmd.com/read/37953834/design-and-fabrication-of-a-nanobiosensor-for-the-detection-of-cell-free-circulating-mirnas-lncrnas-mrnas-triad-grid
#34
JOURNAL ARTICLE
Pooja Ratre, Nazim Nazeer, Arpit Bhargava, Suresh Thareja, Rajnarayan Tiwari, Vinay Singh Raghuwanshi, Pradyumna Kumar Mishra
The increased understanding of the competitive endogenous RNA (ceRNA) network in the onset and development of breast cancers has suggested their use as promising disease biomarkers. Keeping these RNAs as molecular targets, we designed and developed an optical nanobiosensor for specific detection of the miRNAs-LncRNAs-mRNAs triad grid in circulation. The sensor was formulated using three quantum dots (QDs), i.e., QD-705, QD-525, and GQDs. These QDs were surface-activated and modified with a target-specific probe...
October 31, 2023: ACS Omega
https://read.qxmd.com/read/37937546/long-non-coding-rna-lncrna-malat1-in-regulating-osteogenic-and-adipogenic-differentiation-using-a-double-stranded-gapmer-locked-nucleic-acid-nanobiosensor
#35
JOURNAL ARTICLE
Samantha Fasciano, Shuai Luo, Shue Wang
Long non-coding RNAs (lncRNA) are non-protein coding RNA molecules that are longer than 200 nucleotides. The lncRNA molecule plays diverse roles in gene regulation, chromatin remodeling, and cellular processes, influencing various biological pathways. However, probing the complex dynamics of lncRNA in live cells is a challenging task. In this study, a double-stranded gapmer locked nucleic acid (ds-GapM-LNA) nanobiosensor is designed for visualizing the abundance and expression of lncRNA in live human bone-marrow-derived mesenchymal stem cells (hMSCs)...
November 8, 2023: Analyst
https://read.qxmd.com/read/37921102/nanobiosensors-and-nanoformulations-in-agriculture-new-advances-and-challenges-for-sustainable-agriculture
#36
JOURNAL ARTICLE
Cristina Miguel-Rojas, Alejandro Pérez-de-Luque
In the current scenario of climate change, global agricultural systems are facing remarkable challenges in order to increase production, while reducing the negative environmental impact. Nano-enabled technologies have the potential to revolutionise farming practices by increasing the efficiency of inputs and minimising losses, as well as contributing to sustainable agriculture. Two promising applications of nanotechnology in agriculture are nanobiosensors and nanoformulations (NFs). Nanobiosensors can help detect biotic and abiotic stresses in plants before they affect plant production, while NFs can make agrochemicals, more efficient and less polluting...
November 3, 2023: Emerging Topics in Life Sciences
https://read.qxmd.com/read/37887115/emerging-applications-of-nanobiosensors-in-pathogen-detection-in-water-and-food
#37
REVIEW
Hiram Martin Valenzuela-Amaro, Alberto Aguayo-Acosta, Edgar Ricardo Meléndez-Sánchez, Orlando de la Rosa, Perla Guadalupe Vázquez-Ortega, Mariel Araceli Oyervides-Muñoz, Juan Eduardo Sosa-Hernández, Roberto Parra-Saldívar
Food and waterborne illnesses are still a major concern in health and food safety areas. Every year, almost 0.42 million and 2.2 million deaths related to food and waterborne illness are reported worldwide, respectively. In foodborne pathogens, bacteria such as Salmonella , Shiga-toxin producer Escherichia coli , Campylobacter , and Listeria monocytogenes are considered to be high-concern pathogens. High-concern waterborne pathogens are Vibrio cholerae , leptospirosis, Schistosoma mansoni, and Schistosima japonicum , among others...
October 11, 2023: Biosensors
https://read.qxmd.com/read/37857587/layered-architectural-fabrication-of-a-novel-sulfite-nanobiosensor-by-encapsulation-of-sulfite-oxidase-on-a-polypyrrole-multiwalled-carbon-nanotubes-composite-decorated-with-platinum-nanoparticles
#38
JOURNAL ARTICLE
Shahid Hussain, Samuel B Adeloju
The fabrication of a highly selective and ultrasensitive sulfite nanobiosensor based on a layered architectural fabrication aided by the encapsulation of sulfite oxidase (SOx) in Nafion (Naf) matrix on a multiwalled carbon nanotubes-polypyrrole (MWCNTs-PPy) composite decorated with platinum nanoparticles (PtNPs) is described. The MWCNTs are deposited in the inner layer on a Pt electrode during electropolymerization of pyrrole (Py), followed by decoration with a PtNPs layer and subsequent encapsulation of SOx with Naf in the third layer capped with a fourth thin PtNPs layer...
October 19, 2023: Small
https://read.qxmd.com/read/37770648/a-wearable-aptamer-nanobiosensor-for-non-invasive-female-hormone-monitoring
#39
JOURNAL ARTICLE
Cui Ye, Minqiang Wang, Jihong Min, Roland Yingjie Tay, Heather Lukas, Juliane R Sempionatto, Jiahong Li, Changhao Xu, Wei Gao
Personalized monitoring of female hormones (for example, oestradiol) is of great interest in fertility and women's health. However, existing approaches usually require invasive blood draws and/or bulky analytical laboratory equipment, making them hard to implement at home. Here we report a skin-interfaced wearable aptamer nanobiosensor based on target-induced strand displacement for automatic and non-invasive monitoring of oestradiol via in situ sweat analysis. The reagentless, amplification-free and 'signal-on' detection approach coupled with a gold nanoparticle-MXene-based detection electrode offers extraordinary sensitivity with an ultra-low limit of detection of 0...
September 28, 2023: Nature Nanotechnology
https://read.qxmd.com/read/37754131/novel-cytochrome-p450-3a4-enzymatic-nanobiosensor-for-lapatinib-a-breast-cancer-drug-developed-on-a-poly-anilino-co-4-aminobenzoic-acid-green-synthesised-indium-nanoparticle-platform
#40
JOURNAL ARTICLE
Jaymi Leigh January, Ziyanda Zamaswazi Tshobeni, Nokwanda Precious Pearl Ngema, Abongile Nwabisa Jijana, Emmanuel Iheanyichukwu Iwuoha, Takalani Mulaudzi, Samantha Fiona Douman, Rachel Fanelwa Ajayi
Breast cancer (BC) is one of the most common types of cancer disease worldwide and it accounts for thousands of deaths annually. Lapatinib is among the preferred drugs for the treatment of breast cancer. Possible drug toxicity effects of lapatinib can be controlled by real-time determination of the appropriate dose for a patient at the point of care. In this study, a novel highly sensitive polymeric nanobiosensor for lapatinib is presented. A composite of poly(anilino-co-4-aminobenzoic acid) co-polymer {poly(ANI-co-4-ABA)} and coffee extract-based green-synthesized indium nanoparticles (InNPs) was used to develop the sensor platform on a screen-printed carbon electrode (SPCE), i...
September 21, 2023: Biosensors
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