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Nanobiosensor

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https://www.readbyqxmd.com/read/29149830/diagnostic-devices-for-circulating-biomarkers-detection-and-quantification
#1
Chiara Bedin, Sara Crotti, Ennio Tasciotti, Marco Agostini
Nowadays, fast and sensitive methods for biomarkers detection exist, but the performance of most of them still rely in centralized laboratory testing. The development of small, fast and simple to use medical device that can help in making diagnosis accurate and with low-invasiveness is now a major challenge for nanotechnology. To develop diagnostic devices for cancer detection, nanomaterials-based systems have significant advantages over current conventional approaches in terms of simplicity, sensitivity, specificity and rapidity...
November 16, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28968262/optical-biomarker-based-biosensors-for-cancer-infectious-disease-medical-diagnoses
#2
Alireza Gharatape, Ahmad Yari Khosroushahi
Thousands of billions of dollars have been disbursed worldwide for the diagnosis and therapy of disease. Nanobioscience combined with sensing technology has facilitated the pathway to diagnosis by introducing a novel, highly sensitive and selective detection system known as the nanobiosensor to reduce the overall cost of treatment. Among the many types of biosensors, optical ones are more easily developed because of their low cost, rapid construction, small size, high performance, high sensitivity and selectivity, high signal-to-noise ratio, flexible geometry, and portability properties...
September 29, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28961120/photothermal-modeling-and-analysis-of-intra-body-terahertz-nanoscale-communication
#3
Hadeel Elayan, Pedram Johari, Raed M Shubair, Josep Miquel Jornet
Wireless communication among implanted nanobiosensors will enable transformative smart health monitoring and diagnosis systems. The state of the art of nano-electronics and nano-photonics points to the Terahertz (THz) band (0.1-10 THz) and the optical frequency bands (infrared, 30-400 THz, and visible, 400-750 THz) as the frequency range for communication among nano-biosensors. Recently, several propagation models have been developed to study and assess the feasibility of intrabody electromagnetic (EM) nanoscale communication...
September 28, 2017: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/28960221/imaging-of-compartmentalised-intracellular-nitric-oxide-induced-during-bacterial-phagocytosis-using-a-metalloprotein-gold-nanoparticle-conjugate
#4
Richard Leggett, Paul Thomas, María J Marín, Jelena Gavrilovic, David A Russell
Nitric oxide (NO) plays an essential role within the immune system since it is involved in the break-down of infectious agents such as viruses and bacteria. The ability to measure the presence of NO in the intracellular environment would provide a greater understanding of the pathophysiological mechanism of this important molecule. Here we report the detection of NO from the intracellular phagolysosome using a fluorescently tagged metalloprotein-gold nanoparticle conjugate. The metalloprotein cytochrome c, fluorescently tagged with an Alexa Fluor dye, was self-assembled onto gold nanoparticles to produce a NO specific nanobiosensor...
October 23, 2017: Analyst
https://www.readbyqxmd.com/read/28957706/shifting-paradigm-of-cancer-diagnoses-in-clinically-relevant-samples-based-on-miniaturized-electrochemical-nanobiosensors-and-microfluidic-devices
#5
REVIEW
Kuldeep Mahato, Ashutosh Kumar, Pawan Kumar Maurya, Pranjal Chandra
Cancer is one of leading causes of death in the world and occurs in more than two hundred types according to the National Cancer Institute. Its early diagnosis has been remained a prime focus amongst scientists and clinicians since long, not only to understand the complications but also to mitigate its chance of further proliferation. Nowadays, tremendous advances in nanotechnology-empowered diagnostics are serving a substantial input to identify biomarkers associated with various cancers. These biomarkers are found in different forms including overexpressed proteins/surface antigens, metabolites, miRNA, and the entire cell as well...
September 5, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28954256/development-of-a-bifunctional-nanobiosensor-for-screening-and-detection-of-chemokine-ligand-in-colorectal-cancer-cell-line
#6
Saeromi Chung, Pranjal Chandra, Jaseok Peter Koo, Yoon-Bo Shim
Highly sensitive detection of chemokines in various biological matrices and its interaction with a natural receptor molecule has tremendous importance in cell signaling, medical diagnostics, and therapeutics. In this direction, we have designed the first bifunctional nanobiosensor for chemokine screening and detection in a single experimental setting. The sensor probe was fabricated by immobilizing CXCR2 on the gold nanoparticles (AuNPs) deposited 2,2':5',2''-terthiophene-3' (p-benzoic acid) (TBA) nanocomposite film...
September 20, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28946108/nanostructured-materials-with-plasmonic-nanobiosensors-for-early-cancer-detection-a-past-and-future-prospect
#7
REVIEW
Sathish Sugumaran, Mohd Faizal Jamlos, Mohd Noor Ahmad, Chandar Shekar Bellan, Dominique Schreurs
Early cancer detection and treatment is an emerging and fascinating field of plasmonic nanobiosensor research. It paves to enrich a life without affecting living cells leading to a possible survival of the patient. This review describes a past and future prospect of an integrated research field on nanostructured metamaterials, microwave transmission, surface plasmonic resonance, nanoantennas, and their manifested versatile properties with nano-biosensors towards early cancer detection to preserve human health...
August 24, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28858858/detection-of-large-deletion-in-human-brca1-gene-in-human-breast-carcinoma-mcf-7-cells-by-using-dna-silver-nanoclusters
#8
Yasaman Sadat Borghei, Morteza Hosseini, Mohammad Reza Ganjali
Here we describe a label-free detection strategy for large deletion mutation in breast cancer related gene BRCA1 based on a DNA-silver Nanocluster Fluorescence upon Recognition-Induced Hybridization. The specific hybridization of DNA templated silver nanoclusters fluorescent probe to target DNAs can act as effective templates for enhancement of AgNCs Fluorescence, which can be used to distinguish the deletion of BRCA1 due to different fluorescent intensities. Under the optimal conditions, the fluorescent intensity of the DNA-AgNCs increased with the increasing deletion type within a dynamic range from 1...
August 31, 2017: Methods and Applications in Fluorescence
https://www.readbyqxmd.com/read/28840718/detection-and-quantification-of-biologically-active-botulinum-neurotoxin-serotypes-a-and-b-using-a-f%C3%A3-rster-resonance-energy-transfer-based-quantum-dot-nanobiosensor
#9
Yun Wang, H Christopher Fry, Guy E Skinner, Kristin M Schill, Timothy V Duncan
Botulinum neurotoxin (BoNT) is the most potent toxin known. The ingestion of food contaminated with biologically active BoNT causes foodborne botulism, which can lead to respiratory paralysis, coma, and death after ingestion of as little as 70 μg for a 70 kg human. Because of its lethality and challenges associated with current detection methods, there is an urgent need for highly sensitive rapid screening techniques capable of detecting biologically active BoNT. Here, we describe a Förster resonance energy transfer-based nanobiosensor that uses quantum dots (QDs) and two specific quencher-labeled peptide probes to detect and differentiate two biologically active forms of BoNT, serotypes A and B, which were responsible for 80% of human foodborne botulism cases in the U...
September 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28814074/multifunctional-yolk-shell-nanostructure-as-a-superquencher-for-fluorescent-analysis-of-potassium-ion-using-guanine-rich-oligonucleotides
#10
Na Lu, Yanli Wen, Gang Liu, Lei Ding, Caixia Zeng, Ali Aldalbahi, Muhammad Naziruddin Khan, Govindasami Periyasami, Mostafizur Rahaman, Abdulaziz Alrohaili, Jiye Shi, Shiping Song, Lihua Wang, Min Zhang
The excellent performance of a biosensor generally depends on the high signal-to-noise ratio, and the superquencher plays a dominant role in fluorescent sensors. Novel nanoquenchers exhibited high quenching efficiency in various fluorescent assays of biological/chemical molecules. Here, we developed a novel nano-biosensor using Fe3O4@C yolk-shell nanoparticles (YSNPs) and studied their quenching effect. We found Fe3O4@C YSNP was a superquencher and exhibited an ultrastrong quenching ability, up to almost 100% quenching efficiency, toward fluorophores...
September 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28724346/biosensing-technologies-for-therapeutic-drug-monitoring
#11
Anna Meneghello, Stefano Tartaggia, Maria Domenica Alvau, Federico Polo, Giuseppe Toffoli
Therapeutic drug monitoring (TDM) is the clinical practice of measuring pharmaceutical drug concentrations in patients' biofluids at designated intervals to allow a close and timely control of their dosage. This practice allows for rapid medical intervention in case of toxicity-related issues and/or adjustment of dosage to better fit the therapeutic demand. Currently, TDM is performed in centralized laboratories employing instruments, such as immunoassay analyzers and mass spectrometers that can be run only by trained personnel...
July 20, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28721039/top-down-nanofabrication-of-silicon-nanoribbon-field-effect-transistor-si-nr-fet-for-carcinoembryonic-antigen-detection
#12
Zengtao Bao, Jialin Sun, Xiaoqian Zhao, Zengyao Li, Songkui Cui, Qingyang Meng, Ye Zhang, Tong Wang, Yanfeng Jiang
Sensitive and quantitative detection of tumor markers is highly required in the clinic for cancer diagnosis and consequent treatment. A field-effect transistor-based (FET-based) nanobiosensor emerges with characteristics of being label-free, real-time, having high sensitivity, and providing direct electrical readout for detection of biomarkers. In this paper, a top-down approach is proposed and implemented to fulfill a novel silicon nano-ribbon FET, which acts as biomarker sensor for future clinical application...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28629010/fabrication-of-dna-nanotubes-with-an-array-of-exterior-magnetic-nanoparticles
#13
Adele Rafati, Ali Zarrabi, Pooria Gill
Described here a methodology for arraying of magnetic nanoparticles (MNPs) on the surface of DNA nanotubes (DNTs). Positioning of magnetic nanoparticles at exterior surface of DNTs were shaped after self-assembling of oligonucleotide staples within an M13mp18 DNA scaffold via an origami process. The staples were partially labeled with biotin to be arrayed at the surface of DNTs. Gel retardation assay of the DNTs carrying magnetic nanoparticles indicated a reversely behavioral electrophoretic movement in comparison to the nanotubes have been demonstrated previously...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28623816/siderophore-coated-magnetic-iron-nanoparticles-rational-designing-of-water-soluble-nanobiosensor-for-visualizing-al-3-in-live-organism
#14
M Raju, Sakshi Srivastava, Ratish R Nair, Ishan H Raval, Soumya Haldar, Pabitra B Chatterjee
This article aims to establish the judicious use of iron-binding chemistry of microbial chelators in order to functionalize the surface of iron nanoparticles to develop non-toxic nanobiosensor. Anchoring a simple siderophore 2,3-dihydroxybenzoylglycine (H3L), which bears catechol and carboxyl functionalities in tandem, on to the surface of Fe3O4 nanoparticles has developed a unique nanobiosensor HL-FeNPs which showed highly selective and sensitive detection of Al(3+) in 100% water at physiological pH. The biosensor HL-FeNPs, with 20nM limit of detection, behaves reversibly and instantly...
June 8, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28585972/plasmonic-nanohole-array-biosensor-for-label-free-and-real-time-analysis-of-live-cell-secretion
#15
Xiaokang Li, Maria Soler, Cenk I Özdemir, Alexander Belushkin, Filiz Yesilköy, Hatice Altug
Cell secretion dynamics plays a central role in physiological and disease processes. Due to its various temporal profiles, it is essential to implement a precise detection scheme for continuous monitoring of secretion in real time. The current fluorescent and colorimetric approaches hinder such applications due to their multiple time-consuming steps, molecular labeling, and especially the 'snapshot' endpoint readouts. Here, we develop a nanoplasmonic biosensor for real-time monitoring of live cell cytokine secretion in a label-free configuration...
June 6, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28576073/zno-nanoflower-based-sensitive-nano-biosensor-for-amyloid-detection
#16
Najim Akhtar, Sanjay Kisan Metkar, Agnishwar Girigoswami, Koyeli Girigoswami
Zinc oxide (ZnO) is a semiconductor metal oxide nanoparticle with inherent optical properties. Among the different zinc oxide nanostructures, nanoflowers have greater surface area. Utilizing this property a reagentless biosensor has been developed for the detection of beta amyloids, a hallmark of neurodegenerative diseases like Alzheimer's disease, Creutzfeldt-Jakob Syndrome, insulin dependent type II diabetes etc. The poor fluorescence quantum yield and photobleaching effect of Thioflavin T (ThT) upon binding to the model insulin amyloid beta sheets in solution can be overcome by the present engineered biosensor where ThT acts as a target as well as a reporter to detect amyloids adsorbed on a solid template based on ZnO nanoflower...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28487527/development-of-frequency-based-taste-receptors-using-bioinspired-glucose-nanobiosensor
#17
Amin TermehYousefi, Katsumi Tateno, Samira Bagheri, Hirofumi Tanaka
A method to fabricate a bioinspired nanobiosensor using electronic-based artificial taste receptors for glucose diagnosis is presented. Fabricated bioinspired glucose nanobiosensor designated based on an artificial taste bud including an amperometric glucose biosensor and taste bud-inspired circuits. In fact, the design of the taste bud-inspired circuits was inspired by the signal-processing mechanism of taste nerves which involves two layers. The first, known as a type II cell, detects the glucose by glucose oxidase and transduces the current signal obtained for the pulse pattern is conducted to the second layer, called type III cell, to induce synchronisation of the neural spiking activity...
May 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28470301/notch-signaling-in-regulating-angiogenesis-in-a-3d-biomimetic-environment
#18
Yi Zheng, Shue Wang, Xufeng Xue, Alan Xu, Wei Liao, Alice Deng, Guohao Dai, Allen P Liu, Jianping Fu
Angiogenesis is a complex cellular process involving highly orchestrated invasion and organization of endothelial cells (ECs) in a three-dimensional (3D) environment. Recent evidence indicates that Notch signaling is critically involved in regulating specialized functions and distinct fates of ECs in newly formed vasculatures during angiogenesis. Here, we demonstrated, for the first time, the application of a microengineered biomimetic system to quantitatively investigate the role of Notch signaling in regulating early angiogenic sprouting and vasculature formation of ECs in a 3D extracellular matrix...
May 31, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28414950/a-nanobiosensor-composed-of-exfoliated-graphene-oxide-and-gold-nano-urchins-for-detection-of-gmo-products
#19
Zahra Aghili, Navid Nasirizadeh, Adeleh Divsalar, Shahram Shoeibi, Parichehreh Yaghmaei
Genetically Modified Organisms, have been entered our food chain and detection of these organisms in market products are still the main challenge for scientists. Among several developed detection/quantification methods for detection of these organisms, the electrochemical nanobiosensors are the most attended which are combining the advantages of using nanomaterials, electrochemical methods and biosensors. In this research, a novel and sensitive electrochemical nanobiosensor for detection/quantification of these organisms have been developed using nanomaterials; Exfoliated Graphene Oxide and Gold Nano-Urchins for modification of the screen-printed carbon electrode, and also applying a specific DNA probe as well as hematoxylin for electrochemical indicator...
September 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28335308/probe-microscopic-studies-of-dna-molecules-on-carbon-nanotubes
#20
REVIEW
Kazuo Umemura, Katsuki Izumi, Shusuke Oura
Hybrids of DNA and carbon nanotubes (CNTs) are promising nanobioconjugates for nanobiosensors, carriers for drug delivery, and other biological applications. In this review, nanoscopic characterization of DNA-CNT hybrids, in particular, characterization by scanning probe microscopy (SPM), is summarized. In many studies, topographical imaging by atomic force microscopy has been performed. However, some researchers have demonstrated advanced SPM operations in order to maximize its unique and valuable functions...
October 8, 2016: Nanomaterials
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