Diogo Alpuim Costa, Tiago Porfírio Costa, Eduardo Carlinhos Netto, Natércia Joaquim, Isabel Ventura, Ana Cristina Pratas, Patrícia Winckler, Inês Pires Silva, Ana Catarina Pinho, Isabel Goulão Sargento, Francisco Gamito Guerreiro, António Rita Moreira
Over the last decades, several therapeutic options were considered in the treatment of the osteoradionecrosis (ORN) of the mandible, including supportive measures, ultrasound therapy, corticosteroids, hyperbaric oxygen, surgical resection with reconstruction, and, more recently, drugs capable of reversing the fibroatrophic process. Once established, the ORN does not spontaneously disappear and a standard treatment has not yet been defined. The clear clinical effectiveness of hyperbaric oxygen therapy (HBOT) varies according to the literature and there are some economic/logistic issues to be considered; the triplet tocopherol/pentoxifylline/clodronate demands greater evidence from randomized clinical trials and also resilience from the patient, given the long treatment duration and its possible side effects...
November 2016: Head & Neck