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https://www.readbyqxmd.com/read/28637170/neuroprotective-effect-of-pressure-oriented-flow-regulation-and-ph-stat-management-in-selective-antegrade-brain-perfusion-during-total-aortic-arch-repair
#1
Hisato Ito, Toru Mizumoto, Yasuhiro Sawada, Kazuya Fujinaga, Hironori Tempaku, Yasunori Yamamoto, Katsuhiro Tsutsui, Hideto Shimpo
OBJECTIVES: The aim of this study was to assess the safety and effectiveness of our selective antegrade brain perfusion (SABP) strategy, which is characterized by moderate hypothermic and low-pressure management under pH-stat using a completely closed cardiopulmonary bypass circuit with a single centrifugal pump. METHODS: Forty-nine consecutive patients (median age, 74) underwent total aortic arch replacement using a 4-branched graft. SABP was conducted with individual cannulation in all arch vessels...
June 20, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28634492/effectiveness-of-different-preventive-programs-in-cariogram-parameters-of-young-adults-at-high-caries-risk
#2
Said Karabekiroğlu, Nimet Ünlü
OBJECTIVE: To evaluate the effectiveness of different preventive programs in young adults at high caries risk using Cariogram software. METHODS: Sixty-six young adults with high caries risk were evaluated. Dental caries risk for all subjects was determined according to WHO criteria. Subjects were divided into three different preventive groups (control: OH, fluoride varnish: FV, and chlorhexidine varnish: CV). They were followed for 12 weeks (baseline: T0, 1 week: T1, 4 weeks: T2, and 12 weeks: T3)...
2017: International Journal of Dentistry
https://www.readbyqxmd.com/read/28632958/decreased-portal-vein-velocity-is-predictive-of-the-development-of-portal-vein-thrombosis-a-matched-case-control-study
#3
Jonathan G Stine, Jennifer Wang, Puja M Shah, Curtis K Argo, Nicolas Intagliata, Andre Uflacker, Stephen H Caldwell, Patrick G Northup
BACKGROUND & AIMS: Portal vein thrombosis (PVT) in cirrhosis may lead to hepatic decompensation and increased mortality. We aimed to investigate if decreased portal vein (PV) velocity is associated with future PVT. METHODS: Data on adult patients with cirrhosis and PVT between January 1, 2005 and July 30, 2015 were obtained. Cases with PVT were matched by age, gender and Model for End stage Liver Disease (MELD) score to corresponding controls without PVT. Cox proportional hazards models, receiver operator curves and Kaplan Meier curves were constructed...
June 20, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28629636/nasal-high-flow-oxygen-therapy-in-the-ward-setting-a-prospective-observational-study
#4
Alison M Pirret, Susan F Takerei, Claire L Matheson, Meghan Kelly, Wharewaina Strickland, Joanne Harford, Nicola E Jepsen, Lisa J Welsh, Chloe P A Allan
BACKGROUND: Whilst research demonstrates the benefits of nasal high flow oxygen in the intensive care setting, limited literature exists on its benefits in ward patients. OBJECTIVES: This study evaluated the use of nasal high flow oxygen in adult ward patients with respiratory failure or at risk of respiratory deterioration. Primary outcome was an improvement in pulmonary function as indicated by decreases in respiratory and heart rates and an increase in arterial oxygen saturation via pulse oximetry...
June 16, 2017: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/28628045/cardio-respiratory-effects-of-air-pollution-in-a-panel-study-of-outdoor-physical-activity-and-health-in-rural-older-adults
#5
David M Stieb, Robin Shutt, Lisa Kauri, Sarah Mason, Li Chen, Mieczyslaw Szyszkowicz, Nina A Dobbin, Marc Rigden, Branka Jovic, Marie Mulholland, Martin S Green, Ling Liu, Guillaume Pelletier, Scott A Weichenthal, Robert E Dales, Isaac Luginaah
OBJECTIVE: To examine cardio-respiratory effects of air pollution in rural older adults exercising outdoors. METHODS: Adults 55 and over completed measurements of blood pressure, peak expiratory flow and oximetry daily, and of heart rate variability, endothelial function, spirometry, fraction of exhaled nitric oxide and urinary oxidative stress markers weekly, before and after outdoor exercise, for 10 weeks. Data were analyzed using linear mixed effect models. RESULTS: Pooled estimates combining 2013 (n = 36 participants) and 2014 (n = 41) indicated that an interquartile increase in the air quality health index (AQHI) was associated with a significant (P < 0...
April 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28624422/endovascular-proximal-forearm-arteriovenous-fistula-for-hemodialysis-access-results-of-the-prospective-multicenter-novel-endovascular-access-trial-neat
#6
Charmaine E Lok, Dheeraj K Rajan, Jason Clement, Mercedeh Kiaii, Ravi Sidhu, Ken Thomson, George Buldo, Christine Dipchand, Louise Moist, Joanna Sasal
BACKGROUND: Hemodialysis arteriovenous fistulas (AVFs) are suboptimally used primarily due to problems with maturation, early thrombosis, and patient nonacceptance. An endovascular approach to fistula creation without open surgery offers another hemodialysis vascular access option. STUDY DESIGN: Prospective, single-arm, multicenter study (Novel Endovascular Access Trial [NEAT]). SETTINGS & PARTICIPANTS: Consecutive adult non-dialysis-dependent and dialysis-dependent patients referred for vascular access creation at 9 centers in Canada, Australia, and New Zealand...
June 9, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28614775/changes-in-viability-of-rat-adipose-derived-stem-cells-isolated-from-abdominal-perinuclear-adipose-tissue-stimulated-with-pulsed-electromagnetic-field
#7
A Baranowska, B Skowron, B Nowak, K Ciesielczyk, P Guzdek, K Gil, J Kaszuba-Zwoinska
Previous experiments demonstrated that low-frequency electromagnetic field (LF-EMF) may activate cellular death pathways in proliferating cells. Therefore, we hypothesized that LF-EMF may also influence viability of highly proliferating undifferentiated adipose-derived stem cells. Obesity is classified as a civilization disease; its etiopathogenesis is presumed to include both genetic predisposition and influence of modified environmental factors, such as unbalanced diet with excess calories and/or too low physical activity...
April 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28612098/measurement-of-the-maximum-frequency-of-electroglottographic-fluctuations-in-the-expiration-phase-of-volitional-cough-as-a-functional-test-for-cough-efficiency
#8
Toshihiko Iwahashi, Makoto Ogawa, Kiyohito Hosokawa, Chieri Kato, Hidenori Inohara
The hypotheses of the present study were that the maximum frequency of fluctuation of electroglottographic (EGG) signals in the expiration phase of volitional cough (VC) reflects the cough efficiency and that this EGG parameter is affected by impaired laryngeal closure, expiratory effort strength, and gender. For 20 normal healthy adults and 20 patients diagnosed with unilateral vocal fold paralysis (UVFP), each participant was fitted with EGG electrodes on the neck, had a transnasal laryngo-fiberscope inserted, and was asked to perform weak/strong VC tasks while EGG signals and a high-speed digital image of the larynx were recorded...
June 13, 2017: Dysphagia
https://www.readbyqxmd.com/read/28607341/thrombolysis-for-non-traumatic-intra-ventricular-hemorrhage-in-adults-a-critical-reappraisal
#9
Daniele Starnoni, Mauro Oddo, Rodolfo Maduri, Mahmoud Messerer, Roy T Daniel
Intra-ventricular hemorrhage (IVH) is a critical condition with high rate of morbidity and mortality due to acute hydrocephalus and secondary brain injury. Mechanisms underlining the clinical deterioration are not only related to the appearance of an acute hydrocephalus but also to blood- clot mass effect and the inflammatory effects of blood break-down products which impede local blood flow and exert a direct toxic effect on the peri-ventricular structures leading to chronic hydrocephalus. An effective treatment strategy should aim at IVH fast removal and reduction of blood-clot mass effect...
June 12, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28607114/varicella-zoster-virus-specific-cellular-immune-responses-to-the-live-attenuated-zoster-vaccine-in-young-and-older-adults
#10
Adriana Weinberg, Jennifer Canniff, Nadine Rouphael, Aneesh Mehta, Mark Mulligan, Jennifer A Whitaker, Myron J Levin
The incidence and severity of herpes zoster (HZ) increases with age. The live attenuated zoster vaccine generates immune responses similar to HZ. We compared the immune responses to zoster vaccine in young and older to adults to increase our understanding of the immune characteristics that may contribute to the increased susceptibility to HZ in older adults. Young (25-40 y; n = 25) and older (60-80 y; n = 33) adults had similar magnitude memory responses to varicella-zoster virus (VZV) ex vivo restimulation measured by responder cell-frequency and flow cytometry, but the responses were delayed in older compared with young adults...
June 12, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28606846/agreement-between-home-based-measurement-of-stool-calprotectin-and-elisa-results-for-monitoring-inflammatory-bowel-disease-activity
#11
Anke Heida, Mariska Knol, Anneke Muller Kobold, Josette Bootsman, Gerard Dijkstra, Patrick F van Rheenen
BACKGROUND AND AIMS: An increasing number of physicians use repeated measurements of stool calprotectin to monitor intestinal inflammation in patients with inflammatory bowel diseases (IBD). A lateral flow-based rapid test allows patients to measure their own stool calprotectin values at home. The test comes with a software application (IBDoc) that turns a smartphone camera into a results reader. We compared results from this method with those from the hospital-based reader (Quantum Blue) and ELISA analysis...
June 9, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28603374/the-effectiveness-of-short-term-high-intensity-exercise-on-ventilatory-function-in-adults-with-a-high-risk-of-chronic-obstructive-pulmonary-disease
#12
Omar Farouk Helal, Mansour Abdullah Alshehri, Mohamed Salaheldien Alayat, Hammad Alhasan, Abdullah Tobaigy
[Purpose] This study sets out to investigate whether a short-term high-intensity arm ergometer exercise plan can be of benefit to adults whose poor ventilatory function places them at risk of developing chronic obstructive pulmonary disease. [Subjects and Methods] A pre-experimental design with a convenience sample was employed. The study enrolled 30 adult smokers, aged between 18-25 years old, all of whom were at a high risk of chronic obstructive pulmonary disease. The participants did a daily 20-minute high-intensity arm ergometer exercise, at 75% target heart rate, at the same time over a period of three days...
May 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28600950/histamine-promotes-the-differentiation-of-macrophages-from-cd11b-myeloid-cells-and-formation-of-foam-cells-through-a-stat6-dependent-pathway
#13
Lili Xu, Dengfeng Cheng, Zheyong Huang, Suling Ding, Weiwei Zhang, Hui Tan, Hongcheng Shi, Ruizhen Chen, Yunzeng Zou, Timothy C Wang, Xiangdong Yang, Junbo Ge
BACKGROUND AND AIMS: The enzyme histidine decarboxylase (Hdc), which generates histamine, is highly expressed in CD11b(+)Gr-1(+) myeloid cells that play a critical role in infection, inflammation and tumorigenesis. The aim of this study was to explore the role of Hdc-expressing CD11b(+) myeloid cells or histamine in atherogenesis. METHODS: Hdc-EGFP bacterial artificial chromosome (BAC) transgenic reporter mice (Hdc-EGFP) were used to track Hdc expression during the development of atherosclerosis...
May 23, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28598073/-effects-of-fgf-21-on-osteogenic-differentiation-of-human-bone-marrow-mesenchymal-stem-cells-in-high-glucose-environment
#14
Xi Li, Cheng Chen, Zhen-Mei An, Yu-Jue Li, Mei Zhang, He He, Shuang-Qing Li
OBJECTIVES: To determine the effect of fibroblast growth factor-21(FGF-21)on the osteogenic differention of human bone mesenchymal stem cells (hBMSCs) exposed to a hyperglycemia condition in vitro. METHODS: hBMSCs were isolated from adult bone marrows, and identified by Alizarin red and oil red O staining. The expressions of immunophenotype were analysed using flow cytometry (CD105, CD90, CD73, CD44).HBMSCs were divided into control group[glucose (Glu) concentration of 5...
September 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28597991/lack-of-linear-correlation-between-dynamic-and-steady-state-cerebral-autoregulation
#15
Daan L K de Jong, Takashi Tarumi, Jie Liu, Rong Zhang, Jurgen A H R Claassen
The purpose of this study was to investigate the relationship between dynamic (dCA) and steady-state cerebral autoregulation (sCA). In 28 healthy older adults, sCA was quantified by a linear regression slope of proportionate (%) changes in cerebrovascular resistance (CVR) in response to proportionate (%) changes in mean blood pressure (BP) induced by stepwise sodium nitroprusside (SNP) and phenylephrine (PhE) infusion. Cerebral blood flow (CBF) was measured at the internal carotid (ICA) and vertebral (VA) artery and cerebral blood flow velocity (CBFV) at the middle cerebral artery (MCA)...
June 9, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28588575/gut-associated-lymphoid-tissue-a-key-tissue-inside-the-mucosal-immune-system-of-hens-immunized-with-escherichia-coli-f4
#16
Maria F Peralta, Alejandra Magnoli, Fabrisio Alustiza, Armando Nilson, Raúl Miazzo, Adriana Vivas
Immunoglobulin Y (IgY) is the predominant antibody found in hen's (Gallus domesticus) egg yolk. This antibody, developed against several microorganisms in hen egg yolk, has been successfully used as an alternative to immunoglobulins from mammals for use in immunodiagnostics and immunotherapy. Enteropathogenic Escherichia coli (E.coli) F4 is the main etiological agent associated with swine neonatal diarrhea, and it causes notable economic losses in swine production. The aim of the present study was to evaluate the relationship between humoral immune response and the activation of gut-associated lymphoid tissue (GALT) in laying hens intramuscularly immunized with E...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28588117/aerosol-delivery-through-adult-high-flow-nasal-cannula-with-heliox-and-oxygen
#17
Patricia A Dailey, Robert Harwood, Kyle Walsh, James B Fink, Tina Thayer, Greg Gagnon, Arzu Ari
BACKGROUND: Heliox (helium-oxygen mixture) has been shown to reduce turbulence and improve aerosol delivery in a range of clinical settings. We questioned whether heliox as compared with oxygen via high-flow nasal cannula (HFNC) would affect aerosol delivery. We hypothesized that heliox would have a significant effect on aerosol delivery as compared with oxygen with both quiet and distressed breathing patterns. METHODS: A vibrating mesh nebulizer was placed at the inlet of a humidifier via HFNC with small adult cannula distal to the heated-wire circuit with prongs placed into simulated nares with a T-shaped trap and absolute filter connected to a breath simulator set to adult quiet and distressed breathing parameters...
June 6, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28586614/frequency-indications-and-complications-of-pulmonary-artery-catheter-insertion-in-adult-open-heart-surgery-patients-of-a-tertiary-care-hospital
#18
Syed Shabbir Ahmed, Mohammad Irfan Akhtar, Rehana Kamal
OBJECTIVE: Patients presenting for cardiac surgery have unstable cardiovascular disease and haemodynamics with multiple coexisting diseases. Optimal monitoring in the perioperative period is very important for best perioperative outcome. The introduction of the flow-directed pulmonary artery catheter (PAC) into clinical practice is one of the most important and popular advances in the field of cardiac anaesthesia. The objective of the study was to determine the frequency, indications and complications of pulmonary artery catheter insertion in adult open-heart surgery patients...
October 2016: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28585699/impact-of-aging-on-postsynaptic-neuronal-nicotinic-neurotransmission-in-auditory-thalamus
#19
Sarah Y Sottile, Lynne Ling, Brandon C Cox, Donald M Caspary
The flow of auditory information through the medial geniculate body (MGB) is regulated, in part, by cholinergic projections from the pontomesencephalic tegmentum (PMT). The functional significance of these projections is not fully established, but they have been strongly implicated in the allocation of auditory attention. Using in vitro slice recordings, we have analysed postsynaptic function and pharmacology of neuronal nicotinic acetylcholine receptors (nAChRs) in young adult and aged rat MGB. We find that acetylcholine produces significant excitatory postsynaptic actions on young MGB neurons, likely mediated by β2-containing heteromeric nAChRs...
June 6, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28583889/a-diet-rich-in-omega-3-fatty-acids-enhances-expression-of-soluble-epoxide-hydrolase-in-murine-brain
#20
Annika Irmgard Ostermann, Martina Reutzel, Nicole Hartung, Nicole Franke, Laura Kutzner, Kirsten Schoenfeld, Karsten-Henrich Weylandt, Gunter Peter Eckert, Nils Helge Schebb
Several studies suggest that intake of omega-3 polyunsaturated fatty acids (n3-PUFA) beneficially influences cognitive function. However, effects on the adult brain are not clear. Little is known about the impact of dietary intervention on the fatty acid profile in adult brain, the modulation in the expression of enzymes involved in fatty acid biosynthesis and metabolism as well as changes in resulting oxylipins. These questions were addressed in the present study in two independent n3-PUFA feeding experiments in mice...
June 2, 2017: Prostaglandins & Other Lipid Mediators
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