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IgG4- related diseases

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https://www.readbyqxmd.com/read/29243036/mediators-of-angiogenesis-and-fibrosis-in-igg4-related-disease
#1
Ilaria Puxeddu, Riccardo Capecchi, Federico Pratesi, Silvana Cianchetti, Antonio Tavoni, Paola Migliorini
IgG4-related disease (IgG4-RD) is a rare fibro-inflammatory condition that can affect almost any organ, characterized by tumefactive lesions and often by eosinophilia and elevated serum IgG4 concentrations. The aim of the study is to analyze in IgG4-RD patients the serum levels of a group of cytokines and growth factors potentially involved in the regulation of fibrotic processes. In the sera of 12 patients affected by IgG4-RD and of 15 normal healthy subjects (NHS), pro-fibrogenic mediators (TGF-β1 and periostin) and pro- (VEGF and angiogenin-1) and anti- (endostatin and thrombospondin-1) angiogenic mediators were measured by sandwich enzyme immunoassay...
December 14, 2017: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/29242501/high-throughput-rna-sequencing-reveals-distinct-gene-signatures-in-active-igg4-related-disease
#2
Brandon W Higgs, Yanying Liu, Jianping Guo, Yinong Sebastian, Chris Morehouse, Wei Zhu, Limin Ren, Mengru Liu, Yan Du, Guangyan Yu, Lingli Dong, Hong Hua, Pan Wei, Yi Wang, Zhengang Wang, Yihong Yao, Zhan-Guo Li
We aimed to characterize the molecular differences and effects from prednisone treatment among IgG4-related disease with salivary gland lesions (RD-SG), without SG lesions (RD-nonSG), and IgG4-related retroperitoneal fibrosis (RF). RNA sequencing was conducted on blood from 25 RD-SG, 11 RD-nonSG, 3 RF and 10 control subjects. Among these, 8 RD-nonSG and 12 RD-SG patients were subjected to treatment with prednisone and/or glucocorticoid-sparing agents. Six RD patients had a longitudinal time point. The mRNA levels of IgG4 and IgE, genes specific for Th2 cells, eosinophils, and neutrophils were over-expressed in RD-SG and RD-nonSG...
December 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29241876/update-in-ethiopathogeny-diagnosis-and-treatment-of-the-igg4-related-disease
#3
REVIEW
Fernando Martínez-Valle, Olimpia Orozco-Gálvez, Andreu Fernández-Codina
IgG4 related disease (IgG4-RD) is probably an autoimmune pathology of unknown etiology. Diverse interactions participate in its pathogen between the adaptive and innate immune systems, activating lymphocytes B and T which trigger the inflammatory cascade, which culminates in fibrosis of the organs and their malfunction. It can affect a multitude of organs simultaneously. The diagnosis is based on the correlation of clinical findings with anatomopathological results (lymphoplasmocitary infiltrate, storiform fibrosis, obliterative phlebitis and IgG4+plasmatic cell count) and with the presence of elevated IgG4 in serum, depending on the criteria used...
December 11, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/29232794/-clinical-evaluation-of-diagnostic-and-treatment-protocol-of-idiopathic-retroperitoneal-fibrosis-incorporating-consideration-of-possible-igg4-related-disease
#4
Takaya Iyoki, Takeshi Maehana, Toshiaki Tanaka, Motohisa Yamamoto, Hiroki Takahashi, Naoya Masumori
About half of idiopathic retroperitoneal fibrosis might be classified as a IgG4-related disease, a newly characterized disease that is especially known to be sensitive to steroid therapy. We developed a new protocol for diagnosis and treatment of retroperitoneal fibrosis, which included aggressive diagnosis of IgG4- related disease. We retrospectively reviewed 22 cases with idiopathic retroperitoneal fibrosis that were diagnosed and treated according to our protocol. Of them, 10 patients (45.5%) had no evidence of IgG4- related disease (non-IgG4RD group), whereas 12 patients (54...
November 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29229107/clinical-characterization-of-52-patients-with-immunoglobulin-g4-related-disease-in-a-single-tertiary-center-in-japan-special-reference-to-lung-disease-in-thoracic-high-resolution-computed-tomography
#5
Takeshi Saraya, Kosuke Ohkuma, Masachika Fujiwara, Chika Miyaoka, Shoko Wada, Takayasu Watanabe, Sunao Mikura, Manami Inoue, Miku Oda, Mitsuru Sada, Yukari Ogawa, Kojiro Honda, Masaki Tamura, Takuma Yokoyama, Daisuke Kurai, Haruyuki Ishii, Hajime Takizawa
BACKGROUND: Immunoglobulin G4-related disease (IgG4-RD) is a rare multi-organ disorder. Physicians rarely encounter patients with IgG4-RD and its range of symptoms. METHODS: To elucidate the clinical characterization of IgG4-RD, along with the clinical significance of lung involvement, we retrospectively reviewed the medical records of patients who satisfied the comprehensive diagnostic criteria for IgG4-RD. RESULTS: We identified 52 patients with IgG4-RD...
November 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29229083/thoracic-involvement-in-igg4-related-disease-in-a-uk-based-patient-cohort
#6
John P Corcoran, Emma L Culver, Rebekah M Anstey, Ambika Talwar, Charis D Manganis, Tamsin N Cargill, Robert J Hallifax, Ioannis Psallidas, Najib M Rahman, Eleanor Barnes
IgG4-related disease (IgG4-RD) is a multi-system fibro-inflammatory disorder with classical histopathological findings, often in the context of elevated serum IgG4 levels. The thoracic manifestations of IgG4-RD are numerous and can mimic several common and better known conditions. The objective of this study was to outline the frequency and nature of thoracic involvement in a prospective cohort of IgG4-RD patients who met defined diagnostic criteria. Over 40% of IgG4-RD patients had clinicoradiological and/or histological evidence of thoracic involvement, predominantly mediastinal lymphadenopathy, the majority associated with multi-system disease outside the chest...
November 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29222587/gastrointestinal-manifestation-of-immunoglobulin-g4-related-disease-clarification-through-a-multicenter-survey
#7
Kenji Notohara, Terumi Kamisawa, Kazushige Uchida, Yoh Zen, Mitsuhiro Kawano, Satomi Kasashima, Yasuharu Sato, Masahiro Shiokawa, Takeshi Uehara, Hajime Yoshifuji, Hiroko Hayashi, Koichi Inoue, Keisuke Iwasaki, Hiroo Kawano, Hiroyuki Matsubayashi, Yukitoshi Moritani, Katsuhiko Murakawa, Yoshio Oka, Masatoshi Tateno, Kazuichi Okazaki, Tsutomu Chiba
BACKGROUND: Several reports on immunoglobulin (Ig)G4-related disease (IgG4-RD) with gastrointestinal involvement (IgG4-related gastrointestinal disease; IgG4-GID) have been published, although this entity has not been fully established clinicopathologically. Thus, we carried out a multicenter survey. METHODS: Patients with possible IgG4-GID who underwent resection were collected. Histologic slides were reevaluated, and eight cases with diffuse lymphoplasmacytic infiltration but without numerous neutrophils, granulations or epithelioid granulomas were further analyzed...
December 8, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29217085/igg4-related-disease-presenting-as-hoarseness-and-postcricoid-ulcer
#8
Syeda Hamadani, Beverly Wang, Sudhir Gupta
No abstract text is available yet for this article.
December 4, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29208730/rituximab-for-corticosteroid-resistant-relapsing-igg4-related-intracranial-pachymeningitis-report-of-two-cases
#9
Arthur Mageau, Natalia Shor, Matthieu Fisselier, Jennifer Aboab, Augustin Lecler, Celeste Rebours, Homa Adle-Biassette, Olivier Gout, Romain Deschamps
IgG4-related disease is now recognised as an important cause of intracranial and spinal hypertrophic pachymeningitis. Treatment with corticosteroids generally leads to significant clinical improvement. We present two cases of IgG4 pachymeningitis unresponsive to corticosteroids who improved with rituximab.
December 5, 2017: Practical Neurology
https://www.readbyqxmd.com/read/29204759/ocular-manifestations-of-igg4-related-disease-in-children-more-common-than-anticipated-review-of-the-literature-and-case-report
#10
REVIEW
Roubini G Smerla, Dimitra Rontogianni, George E Fragoulis
IgG4-related disease (IgG4-RD) is an entity with various clinical manifestations. Histopathologically, it is characterized by lymphoplasmacytic infiltrates enriched in IgG4 (+) plasmacytes and usually fibrosis of the affected tissue. Most of the patients have also increased IgG4 serum levels and they respond to glucocorticosteroids. In children, due to its rare occurrence, IgG4-RD is ill defined. From the published studies, so far, it appears that ocular manifestations are very common in the paediatric population with IgG4-RD...
December 4, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29196804/igg4-related-disease-with-emphasis-on-the-biopsy-diagnosis-of-autoimmune-pancreatitis-and-sclerosing-cholangitis
#11
REVIEW
Sönke Detlefsen, Günter Klöppel
In 2011, chronic fibroinflammatory processes occurring simultaneously or metachronously in various organs and associated with elevated IgG4 serum levels and/or tissue infiltration with IgG4-positive plasma cells have been recognized as manifestations of a systemic disorder called IgG4-related disease (IgG4-RD). The histologic key findings are lymphoplasmacytic infiltration rich in IgG4-positive plasma cells combined with storiform fibrosis and obliterative phlebitis. Among the organs mainly affected by IgG4-RD are the pancreas and the extrahepatic bile ducts...
December 1, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29193952/-transient-central-diabetes-insipidus-associated-with-pregnancy-case-report-and-bibliography-review
#12
Luis Francisco Del Carpio-Orantes, Olga Lidia Vera-Lastra, Lucía Carrazco-Ibarra, Alejandra Carrasco-Gómez, Martín Becerril-Ángeles, Patricia Ramos-Salazar, Jaime Martínez-Solano
IgG4-related disease is an inflammatory condition characterized by high levels of IgG4. It affects salivary and lacrimal glands, pancreas, lymph nodes, lungs or kidney. The diagnosis is based on identifying a histological pattern with a dense lymphocyte and plasmacyte infiltration, focal fibrosis or phlebitis, finding more than 10 IgG4 positive cells per high power field and/or IgG4/IgG ratio in plasma higher than 40%. We present a patient with Mikulicz's disease who meets histological findings required for the diagnosis of IgG4 related disease...
September 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29191210/new-clues-to-the-nature-of-immunoglobulin-g4-related-disease-a-retrospective-japanese-multicenter-study-of-baseline-clinical-features-of-334-cases
#13
Kazunori Yamada, Motohisa Yamamoto, Takako Saeki, Ichiro Mizushima, Shoko Matsui, Yuhei Fujisawa, Satoshi Hara, Hiroki Takahashi, Hideki Nomura, Shigeyuki Kawa, Mitsuhiro Kawano
BACKGROUND: The aim was to further characterize immunoglobulin G4-related disease (IgG4-RD) by a large-scale multicenter study of its clinical and laboratory features conducted by multidisciplinary physicians of IgG4-RD in Japan. METHODS: Various specialists retrospectively evaluated IgG4-RD patients diagnosed between 1996 and 2015 in five hospitals by analyzing their baseline clinical features, laboratory, imaging, and pathological test findings, and treatment...
December 1, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29190875/-igg4-related-disease-a-case-report
#14
Luis Francisco Pineda-Galindo, Olga Lidia Vera-Lastra, Lucía Carrazco-Ibarra, Alejandra Carrasco-Gómez, Martín Becerril-Ángeles, Patricia Ramos-Salazar, Jaime Martínez-Solano
IgG4-related disease is an inflammatory condition characterized by high levels of IgG4. It affects salivary and lacrimal glands, pancreas, lymph nodes, lungs or kidney. The diagnosis is based on identifying a histological pattern with a dense lymphocyte and plasmacyte infiltration, focal fibrosis or phlebitis, finding more than 10 IgG4 positive cells per high power field and/or IgG4/IgG ratio in plasma higher than 40%. We present a patient with Mikulicz's disease who meets histological findings required for the diagnosis of IgG4 related disease...
November 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29188490/igg4-related-disease-of-the-appendix
#15
Fadl H Veerankutty, Suhail Saleem, Sidharth Chacko, Vipin I Sreekumar, Prasad Krishnan, Deepak Varma, Prakash Kurumboor
No abstract text is available yet for this article.
November 29, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29188168/igg4-related-pancreatitis-and-immune-thrombocytopenia-a-case-report-and-literature-review
#16
Claire Sakiyama, Stephen Sullivan
A patient with a prior diagnosis of IgG4-related autoimmune pancreatitis (AIP) presented four years later with severe prednisone resistant immune thrombocytopenia (ITP). Her case is reported and the scant literature of the very unusual possible association of IgG4-related AIP and ITP is reviewed. It is suggested that investigation for IgG4-related disease be part of the work-up of ITP.
September 28, 2017: Curēus
https://www.readbyqxmd.com/read/29171863/schistosoma-mansoni-specific-immune-responses-and-allergy-in-uganda
#17
Gyaviira Nkurunungi, Joyce Kabagenyi, Margaret Nampijja, Richard E Sanya, Bridgious Walusimbi, Jacent Nassuuna, Emily L Webb, Alison M Elliott
Low allergy-related disease (ARD) prevalence in low-income countries may be partly attributed to helminth infections. In the Schistosoma mansoni (Sm)-endemic Lake Victoria islands (Uganda), we recently observed positive helminth-allergy associations, despite low ARD prevalence. To understand how Sm-induced cytokine and antibody profiles might influence allergic response profiles in this population, we assessed Schistosoma worm (SWA)- and egg antigen (SEA)-specific Th1 (IFN-γ), Th2 (IL-5, IL-13) and regulatory (IL-10) cytokine profiles (n=407), and total (n=471), SWA-, SEA- and allergen (house dust mite [HDM] and cockroach)-specific (as)IgE and IgG4 profiles (n=2117) by ELISA...
November 24, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/29164005/study-of-systemic-disease-igg4-usefulness-of-2-18f-fluoro-2-deoxy-d-glucose-positron-emission-tomography-computed-tomography-for-staging-selection-of-biopsy-site-evaluation-of-treatment-response-and-follow-up
#18
Guillermo Martinez-Pimienta, Edel Noriega-Álvarez, Marc Simó-Perdigó
Immunoglobulin G4-related systemic disease (IgG4-RSD) is a recently emerging disorder characterized by swelling lesions with storiform fibrosis and lymphoplasmacytic infiltration enriched with IgG4-positive plasma cells. IgG4-RSD has been found in multiple organs/tissues. The diagnosis requires the integration of clinical, serological, imaging, histopathological, and immunohistological features. The 2-[18F]-fluoro-2-deoxy-D-glucose-positron emission tomography/computed tomography (18F-FDG PET/CT) enables the acquisition of whole-body images and provides functional information about disease activity...
September 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/29157939/lymphadenopathy-associated-with-igg4-related-disease-diagnosis-differential-diagnosis
#19
REVIEW
Mark R Wick, Dennis P O'Malley
IgG4-related sclerosing disease, which now encompasses diverse organ-related disorders with various prior eponymic designations, may also present with solitary or multifocal lymph node enlargement. This review considers the histopathologic features of IgG4 lymphadenopathy (IgG4LAD), which has been subdivided by Cheuk & Chan into 5 microscopic subtypes. Those include variants that are typified by multicentric Castleman disease (MCD)-like changes, follicular hyperplasia, interfollicular lymphoplasmacytic proliferation, progressive transformation of germinal centers, and formation of inflammatory pseudotumor (IPT)-like lesions...
November 11, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29155962/igg4-related-disease-presenting-with-raised-serum-igg2-real-timeline-of-igg4-rd
#20
Lisa Dunkley, Hardeep S Mudhar
No abstract text is available yet for this article.
October 9, 2017: Rheumatology
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