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IgG4- related diseases

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https://www.readbyqxmd.com/read/29025159/igg4-related-disease-and-anca-positivity-an-overlap-syndrome
#1
J Bravais, M Pogliaghi, M Polivka, D Sène, M Roriz
No abstract text is available yet for this article.
July 11, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29023932/xanthogranulomatous-cholecystitis-exhibits-overlapping-histologic-features-with-igg4-related-cholecystitis
#2
Soon Auck Hong, You Na Sung, Hyoung Jung Kim, Sang Soo Lee, Jae Hoon Lee, Chul-Soo Ahn, Shin Hwang, Eunsil Yu, Yoh Zen, Myung-Hwan Kim, Seung-Mo Hong
AIMS: Xanthogranulomatous cholecystitis (XGC), an unusual histologic variant of chronic cholecystitis, is characterized by mixed foamy histiocytic and lymphoplasmocytic infiltration and fibrosis. Radiologically, the poorly defined nodular growth pattern often leads to the misinterpretation of XGC as gallbladder cancer. In this study, we aimed to identify the relationship of XGC with IgG4-related cholecystitis, METHODS AND RESULTS: We re-evaluated 57 surgically resected XGCs and 104 conventional chronic cholecystitis cases, according to the histologic features observed in IgG4-related disease, including lymphoplasmocytic infiltration, storiform fibrosis, obliterative phlebitis, and IgG4-positive plasma cells...
October 11, 2017: Histopathology
https://www.readbyqxmd.com/read/29021429/sclerosing-esophagitis-with-igg4-positive-plasma-cell-infiltration-a-case-report
#3
Shigeo Mori, Yoshiya Tahashi, Kazushige Uchida, Tsukasa Ikeura, Naoyuki Danbara, Takahiro Wakamatsu, Takeo Kusuda, Yu Takahashi, Masato Yanagawa, Mitsunobu Matsushita, Chisato Ohe, Taku Michiura, Kentaro Inoue, Masanori Kon, Kazuichi Okazaki
The patient was a 76-year-old woman who had noticed slight difficulty in swallowing in the 3 years prior to this presentation. Her dysphagia progressed while she was hospitalized following cervical cancer surgery. Esophagogastroduodenoscopy and an esophagram showed circumferential erosion and a stricture of the thoracic esophagus. Esophageal resection was performed; the resected specimens showed a stricture and wall thickening. Histologically, transmural hyperplasia, which consisted of inflammatory granulation tissue with the abundant infiltration of IgG4-positive plasma cells and lymphocytes, was observed...
October 11, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28993052/nivolumab-in-patients-with-advanced-gastric-or-gastro-oesophageal-junction-cancer-refractory-to-or-intolerant-of-at-least-two-previous-chemotherapy-regimens-ono-4538-12-attraction-2-a-randomised-double-blind-placebo-controlled-phase-3-trial
#4
Yoon-Koo Kang, Narikazu Boku, Taroh Satoh, Min-Hee Ryu, Yee Chao, Ken Kato, Hyun Cheol Chung, Jen-Shi Chen, Kei Muro, Won Ki Kang, Kun-Huei Yeh, Takaki Yoshikawa, Sang Cheul Oh, Li-Yuan Bai, Takao Tamura, Keun-Wook Lee, Yasuo Hamamoto, Jong Gwang Kim, Keisho Chin, Do-Youn Oh, Keiko Minashi, Jae Yong Cho, Masahiro Tsuda, Li-Tzong Chen
BACKGROUND: Patients with advanced gastric or gastro-oesophageal junction cancer refractory to, or intolerant of, two or more previous regimens of chemotherapy have a poor prognosis, and current guidelines do not recommend any specific treatments for these patients. We assessed the efficacy and safety of nivolumab, a fully human IgG4 monoclonal antibody inhibitor of programmed death-1 (PD-1), in patients with advanced gastric or gastro-oesophageal junction cancer who had been previously been treated with two or more chemotherapy regimens...
October 5, 2017: Lancet
https://www.readbyqxmd.com/read/28988418/clinical-utility-of-18-f-fluorodeoxyglucose-positron-emission-tomography-in-diagnosis-of-immunoglobulin-g4-related-sclerosing-sialadenitis
#5
Kenichi Takano, Ryoto Yajima, Ryuta Kamekura, Motohisa Yamamoto, Hiroki Takahashi, Naoya Yama, Masamitsu Hatakenaka, Tetsuo Himi
OBJECTIVES/HYPOTHESIS: The aim of this study was to evaluate the utility of (18) F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for accurately diagnosing immunoglobulin G4-related sclerosing sialadenitis (IgG4-SS). STUDY DESIGN: Retrospective cohort study. METHODS: We reviewed the records of 64 patients with IgG4-SS (35 male and 29 female patients) and 10 patients with clinically suspected IgG4-SS. Pathological diagnoses of patients clinically suspected with IgG4-SS included four cases of malignant lymphoma, one case of multicentric Castleman disease, one case of Sjögren's syndrome, and four cases of sialadenitis...
October 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28987847/mikulicz-s-disease-mimicking-intraorbital-tumors
#6
Satoshi Murai, Mitsuo Kuriyama, Kaoru Terasaka
We report a case of Mikulicz's disease (MD), an immunoglobulin G4 (IgG4)-related disease that affects the lacrimal and salivary glands. IgG4-related disease is a relatively new clinical entity, and not commonly encountered by neurosurgeons. MD sometimes mimics intraorbital tumors such as malignant lymphoma, but responds well to corticosteroid treatment. Thus, it is important to recognize the clinical and radiographic features of MD.
October 5, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28987046/-igg4-related-disease-a-case-report
#7
Justyna Milczarek-Banach, Kinga Brodzińska, Anna Jankowska, Urszula Ambroziak, Benedykt Szczepankiewicz, Jolanta Nałęcz-Janik, Piotr Miśkiewicz
Immunoglobulin G4-related disease (IgG4-RD) is a comparatively new condition that may involve more than one organ. The lack of characteristic, pathognomonic clinical symptoms may delay the diagnosis of this disease. The diagnosis is based upon clinical manifestation, elevated serum levels of IgG4 and histopathologic examination with immunohistochemical staining to reveal infiltration of IgG4-positive plasma cells. The first line treatment is oral glucocorticoids. A CASE REPORT: 38-year-old woman with Hashimoto disease, chronic sinusitis and chronic hepatitis of unknown etiology was admitted to the Department of Endocrinology because of moderate eyelids swelling accompanied by redness for 3 years...
September 29, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28984432/igg4-related-disease-presenting-as-a-temporal-lobe-tumor
#8
Benjamin W Chan, Richard C Chan, James Cupples
No abstract text is available yet for this article.
December 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28980311/frequent-immunoglobulin-g4-expression-in-a-common-variant-of-primary-cutaneous-marginal-zone-b-cell-lymphoma
#9
Jing Ru Sun, Lin Nong, Xiao Qing Liu, Ping Tu, Yang Wang
Immunoglobulin (Ig)G4 expression was recently observed in a proportion of primary cutaneous marginal zone B-cell lymphoma (PCMZL) with plasmacytic differentiation. IgG4-related disease is characterised by polyclonal lymphoplasmacytic infiltration with IgG4 expression, storiform fibrosis and obliterative phlebitis in histopathology. Here we report three cases of common variants of PCMZL with predominant and varied IgG4 expression, suggesting there is an underlying clonal progression between these two entities...
October 4, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28978347/clinical-features-of-igg4-related-periaortitis-periarteritis-based-on-the-analysis-of-179-patients-with-igg4-related-disease-a-case-control-study
#10
Makiko Ozawa, Yasunari Fujinaga, Junpei Asano, Akira Nakamura, Takayuki Watanabe, Tetsuya Ito, Takashi Muraki, Hideaki Hamano, Shigeyuki Kawa
BACKGROUND: Immunoglobulin G4-related disease (IgG4-RD) is a newly recognized systemic condition characterized by high serum immunoglobulin G4 (IgG4) concentration and IgG4-bearing plasma cell infiltration in affected organs. Although it has become evident that IgG4-RD also involves the systemic aortic/arterial system, the precise details of this condition remain unclear. The present study sought to clarify the clinical features of IgG4-related periaortitis/periarteritis. METHODS: Among 223 patients with IgG4-RD, 179 (131 male, median onset age 67 years) were recruited for this study...
October 4, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28977663/quantitative-measurement-of-18f-fdg-pet-ct-uptake-reflects-the-expansion-of-circulating-plasmablasts-in-igg4-related-disease
#11
Alvise Berti, Emanuel Della-Torre, Francesca Gallivanone, Carla Canevari, Raffaella Milani, Marco Lanzillotta, Corrado Campochiaro, Giuseppe Alvise Ramirez, Emanuele Bozzalla Cassione, Enrica Bozzolo, Federica Pedica, Isabella Castiglioni, Paolo Giorgio Arcidiacono, Gianpaolo Balzano, Massimo Falconi, Luigi Gianolli, Lorenzo Dagna
Objective: [ 18 F]Fluorodeoxyglucose ( 18 F-FDG) PET/CT is increasingly used to assess organ involvement and response to treatment in IgG4-related disease (IgG4-RD), but clear correlations between 18 F-FDG uptake and disease activity have not been established yet. We aimed to correlate the intensity and distribution of 18 F-FDG uptake with validated clinical, serological and immunological parameters of IgG4-RD activity. Methods: Twenty patients with active IgG4-RD underwent a baseline 18 F-FDG PET/CT...
July 7, 2017: Rheumatology
https://www.readbyqxmd.com/read/28972022/risk-factors-for-extraophthalmic-involvement-and-treatment-outcomes-in-patients-with-igg4-related-ophthalmic-disease
#12
Jinku Park, Min Joung Lee, Namju Kim, Ji Eun Kim, Sun-Won Park, Ho-Kyung Choung, Sang In Khwarg
BACKGROUND/AIM: To analyse the clinical risk factors for extraophthalmic involvement and treatment outcomes in patients with IgG4-related ophthalmic disease (IgG4-ROD) in Korea. METHODS: We retrospectively reviewed medical records of 42 patients diagnosed with IgG4-ROD confirmed by a surgical biopsy during the 7-year period, between January 2009 and March 2015, at three tertiary referral centres in Korea. Data regarding patients' demographics, clinical characteristics and radiological findings were obtained...
September 28, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28968906/letter-to-the-editor-case-report-to-distinguish-igg4-related-disease-from-seronegative-granulomatosis-with-polyangiitis
#13
A Faiz Karim, Rob M Verdijk, A Paul Nagtegaal, Rakesh Bansie, Dion Paridaens, P Martin van Hagen, Jan A M van Laar
No abstract text is available yet for this article.
September 5, 2017: Rheumatology
https://www.readbyqxmd.com/read/28960118/repeat-biopsy-of-igg4-related-ophthalmic-disease-identifies-superimposed-herpes-simplex-virus-infection-a-case-report
#14
Abhimanyu Amarnani, Maksim Agaronov, David Ozeri
No abstract text is available yet for this article.
September 29, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28959455/distinct-features-distinguishing-igg4-related-disease-from-multicentric-castleman-s-disease
#15
Takanori Sasaki, Mitsuhiro Akiyama, Yuko Kaneko, Takehiko Mori, Hidekata Yasuoka, Katsuya Suzuki, Kunihiro Yamaoka, Shinichiro Okamoto, Tsutomu Takeuchi
OBJECTIVES: Differentiating IgG4-related disease (IgG4-RD) from multicentric Castleman's disease (MCD) is challenging because both diseases present high serum IgG4. The objective of this study is to clarify the differences in characteristics and identify a clinically useful approach to differentiate these two diseases. METHODS: Forty-five consecutive patients with untreated active IgG4-RD and 33 patients with MCD were included in this study, who visited our institution from January 2000 to August 2016...
2017: RMD Open
https://www.readbyqxmd.com/read/28958166/igg4-related-disease-presenting-as-intradural-extramedullary-lesion-a-case-report-and-review-of-the-literature
#16
Kelly J Bridges, Caitlin H DeDeaux, Khoi D Than
OBJECT: IgG4-related disease (IgG4-RD) is a fibro-inflammatory disorder affecting various anatomical sites, and only recently was identified to affect the dura of the spine. The authors present the second reported case of an intradural extramedullary lesion consistent with IgG4-related spinal disease. METHODS: A literature review was performed that identified 15 other cases of spinal disease, and common features of all known reported spinal IgG4-RD are discussed...
September 28, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28951947/cholangiocarcinoma-and-its-mimickers-in-primary-sclerosing-cholangitis
#17
REVIEW
Jonghun John Lee, Sebastian T Schindera, Hyun-Jung Jang, Scott Fung, Tae Kyoung Kim
Cholangiocarcinoma (CCA) is the most common malignancy in primary sclerosing cholangitis (PSC). Approximately half of CCA are diagnosed within two years of initial diagnosis and often have a poor prognosis because of advanced tumor stage at the time of diagnosis. Thus, rigorous initial imaging evaluation for detecting CCA is important. CCA in PSC usually manifests as intrahepatic mass-forming or perihilar periductal-infiltrating type. Imaging diagnosis is often challenging due to pre-existing biliary strictures and heterogeneous liver...
September 26, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28950319/igg4-related-disease-of-the-lung-a-rare-differential-diagnosis-to-lung-cancer-after-positive-positron-emission-tomography-and-biopsy
#18
Adrian Zehnder, Gregor J Kocher, Michael Seitz, Ralph A Schmid
Immunoglobulin G4-related disease is a rare immune-mediated condition that often causes serious diagnostic problems. Symptoms are unspecific, and several organs can be involved. To date, IgG4-related lung disease has seldom been reported in literature. Nevertheless, a variety of pulmonary involvement has been described, which can mimic malignancy. The gold standard for the diagnosis is the identification of typical histopathological features, even if diagnostic biomarker such as serum IgG4 concentration can be an indicator for a more aggressive course of the disease...
July 25, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28934889/clinical-outcomes-after-endovascular-repair-and-open-surgery-to-treat-immunoglobulin-g4-related-and-nonrelated-inflammatory-abdominal-aortic-aneurysms
#19
Satomi Kasashima, Fuminori Kasashima, Atsuhiro Kawashima, Masamitsu Endo, Yasushi Matsumoto, Kengo Kawakami
PURPOSE: To compare the follow-up results of endovascular aneurysm repair (EVAR) vs open surgery (OS) for inflammatory abdominal aortic aneurysms (IAAAs) with regard to immunoglobulin G4-related diseases (IgG4-RD), which are fibrous inflammatory conditions characterized by elevated serum IgG4 concentrations and numerous infiltrations of IgG4(+) plasmacytes. METHODS: Between January 2005 and December 2015, 91 patients were treated with EVAR (begun in 2008) and 166 patients underwent OS for AAA...
September 1, 2017: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/28928271/the-value-of-18-f-fdg-pet-ct-in-identifying-the-cause-of-fever-of-unknown-origin-fuo-and-inflammation-of-unknown-origin-iuo-data-from-a-prospective-study
#20
Verena Schönau, Kristin Vogel, Matthias Englbrecht, Jochen Wacker, Daniela Schmidt, Bernhard Manger, Torsten Kuwert, Georg Schett
BACKGROUND: Fever of unknown origin (FUO) and inflammation of unknown origin (IUO) are diagnostically challenging conditions. Diagnosis of underlying disease may be improved by (18)F-fluorodesoxyglucose positron emission tomography ((18)F-FDG-PET). METHODS: Prospective study to test diagnostic utility of (18)F-FDG-PET/CT in a large cohort of patients with FUO or IUO and to define parameters that increase the likelihood of diagnostic (18)F-FDG-PET/CT. Patients with FUO or IUO received (18)F-FDG-PET/CT scanning in addition to standard diagnostic work-up...
September 19, 2017: Annals of the Rheumatic Diseases
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