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IgG4- related diseases

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https://www.readbyqxmd.com/read/29682110/igg4-related-arterial-disease
#1
REVIEW
Fuminori Kasashima, Kengo Kawakami, Yasushi Matsumoto, Masamitsu Endo, Satomi Kasashima, Atsuhiro Kawashima
Immunoglobulin G4-related diseases (IgG4-RD) are systemic inflammatory conditions, characterized by high serum IgG4 concentrations, and pathologically IgG4-positive plasmacytes infiltrations and storiform fibrosis. We described IgG4-related inflammatory abdominal aortic aneurysm in 2008, and revealed the existence of vascular lesions. IgG4-related vascular lesions frequently occur in the aorta and branching medium-sized arteries with or without aneurysmal change. The inflammatory lesion mainly involves in the adventitia, indicating remarkable adventitial fibrous thickening with infiltration of inflammatory cells...
March 25, 2018: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29681634/urological-manifestations-of-the-disease-related-to-immunoglobulin-g4
#2
Luis Daniel Carrillo-Córdova, Carlos Alberto Carrillo-Córdova, Johnatan Vitar-Sandoval, Jorge Jaspersen-Álvarez, Elba Luz Villena-López, Raúl Carrillo-Esper
Immunoglobulin G4 related disease (IgG4-RD) is a fibro-inflammatory disease of unknown etiology, characterized by lesions in the form of tumors, elevated serum IgG4 levels, plasma cells with significant IgG4 infiltration, accompanied by phlebitis obliterans and fibrosis. This disease usually has multiorgan disease, including pancreas, biliary tract, salivary glands, peri orbital tissues, kidneys, lungs, lymph nodes and retro peritoneum. IgG4-RD mainly affects men with a predominance of age by young adults until old age...
2018: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/29675343/immunoglobulin-g4-related-ophthalmic-disease
#3
REVIEW
Wei-Kuang Yu, Chieh-Chih Tsai, Shu-Ching Kao, Catherine Jui-Ling Liu
Immunoglobulin G4-related disease (IgG4-RD) is a recently recognized inflammatory disease of unknown etiology. It characterized by distinctive histopathological appearance of dense IgG4-positive lymphoplasmacytic infiltrates, storiform fibrosis, and obliterative phlebitis in one or more organs, simultaneously or subsequently. In cases of ocular adnexal involvement, unique clinicohistopathological features were delineated by recent studies, and IgG4-related ophthalmic disease (IgG4-ROD) is generally recognized as the disease name...
January 2018: Taiwan Journal of Ophthalmology
https://www.readbyqxmd.com/read/29672582/changes-in-n-glycans-of-igg4-and-its-relationship-with-the-existence-of-hypocomplementemia-and-individual-organ-involvement-in-patients-with-igg4-related-disease
#4
Naoki Konno, Mitsuru Sugimoto, Tadayuki Takagi, Makiko Furuya, Tomoyuki Asano, Shuzo Sato, Hiroko Kobayashi, Kiyoshi Migita, Yoshiaki Miura, Taichi Aihara, Atsushi Komatsuda, Hiromasa Ohira, Hiroshi Watanabe
BACKGROUND: Although increased serum IgG4 level and tissue infiltration of IgG4-positive cells are key events in IgG4-related disease (IgG4RD), and nearly half of IgG4RD patients show hypocomplementemia, the role of IgG4 in the pathogenesis of IgG4RD remains unclear. Many reports show that altered IgG glycosylation, especially IgG with agalactosylated N-linked glycan (G0 N-glycan), have proinflammatory roles including complement activation, implicated in the pathogenesis of various inflammatory diseases...
2018: PloS One
https://www.readbyqxmd.com/read/29672431/case-of-primary-isolated-subconjunctival-igg4-related-disease
#5
Hyo Seok Lee, Won Choi, Ga Eon Kim, Kyung Chul Yoon
PURPOSE: To report a case of isolated subconjunctival ocular adnexal IgG4-related disease that met the diagnostic criteria according to the Japanese Ministry of Health, Labour and Welfare's 2011 guidelines. METHODS: We report a case of a 56-year-old woman with a left subconjunctival mass for 3 months. Excisional biopsy was performed. Postoperatively, the patient underwent systemic and radiologic evaluations for IgG4-related disease. RESULTS: The clinicopathologic study revealed storiform fibrosis and lymphoplasmacytic infiltration, with increased IgG4-positive plasma cells and an IgG4/IgG-positive plasma cell ratio of 40%...
April 18, 2018: Cornea
https://www.readbyqxmd.com/read/29666725/elevated-serum-igg4-levels-in-a-young-patient-with-polyserositis-and-necator-americanus-infection
#6
Giuseppe D Sanna, Roberto Manetti, Valentina de Filippo, Sergio Babudieri
IgG4-related disease is a fibroinflammatory systemic condition characterized by tumefactive lesions, lymphoplasmacytic infiltrate rich in IgG4-positive plasma cells, storiform fibrosis, and elevated serum IgG4 concentrations. It has been described in virtually every organ system. Autoimmunity and infectious agents are potential immunologic triggers in IgG4-related disease. Herein, we describe a peculiar case of effusive-constrictive pericarditis in an 18-year-old boy with polyserositis and concomitant Necator americanus infection...
2018: Case Reports in Immunology
https://www.readbyqxmd.com/read/29657677/immunoglobulin-g4-related-disease-an-update
#7
REVIEW
Abdullah Al-Mujaini, Murtadha Al-Khabori, Kashinatha Shenoy, Upender Wali
Immunoglobulin G4-related disease (IgG4-RD) is an increasingly recognized immune-mediated condition comprised of a collection of disorders that share specific pathological, serological, and clinical features. IgG4-RD is a fibroinflammatory condition with a tendency to form tumors with inflammatory infiltrate with IgG4 rich plasma cells and elevation of serum IgG4, which may affect virtually every organ and tissue. IgG4-related ophthalmic disease may present as dacryoadenitis, myositis, or involvement of other orbital tissue...
March 2018: Oman Medical Journal
https://www.readbyqxmd.com/read/29655493/hepatic-inflammatory-pseudotumor-related-with-igg4
#8
Oleksandr Legkiy, Justyna Wajda, Anna Ćwierz, Joanna Wysocka, Andrzej L Komorowski
BACKGROUND: Hepatic inflammatory pseudotumor (HIP) related to IgG4 is a poorly understood entity. It is a rare finding that can simulate malignant liver tumors. Pathogenesis has been associated with pathological inflammatory response. Corticosteroids are considered standard of care once a firm diagnosis has been established. CASE REPORT: We report a case of a 60-year-old man with chronic pancreatitis who was admitted to our hospital with suspicious liver tumor. Imaging studies were inconclusive...
April 11, 2018: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/29629225/igg4-related-disease-in-the-stomach-which-was-confused-with-gastrointestinal-stromal-tumor-gist-two-case-reports-and-review-of-the-literature
#9
Ho Seok Seo, Yoon Ju Jung, Cho Hyun Park, Kyo Young Song, Eun Sun Jung
Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated fibro-inflammatory disorder characterized by specific pathological findings and elevated serum IgG4 level. IgG4-RD in the stomach is rare, and occasionally diagnosed as gastric subepithelial tumor (SET) by endoscopy or computed tomography scan. Two female patients in the age group of 40-50 years were diagnosed with 4 cm sized gastric SET. One underwent laparoscopic gastric wedge resection. Another one had a history of subtotal gastrectomy for early gastric cancer and idiopathic thrombocytopenic purpura with oral steroids administration...
March 2018: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/29622113/imaging-of-sj%C3%A3-gren-syndrome-and-immunoglobulin-g4-related-disease-of-the-salivary-glands
#10
REVIEW
Akifumi Fujita
The salivary glands are commonly affected in systemic autoimmune disease and diseases of unknown pathogenesis. Sjögren syndrome (SjS) can be affected by other systemic diseases. Immunoglobulin G4-related disease (IgG4-RD) commonly affects salivary glands. Imaging findings are usually nonspecific; however, radiologists should be familiar with the manifestations to avoid diagnostic delay. Findings of early-stage SjS are difficult to identify on routine computed tomography or MR imaging. Chronic SjS can be diagnosed from MR imaging and sialographic findings...
May 2018: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/29619414/hilar-cholangiocarcinoma-associated-with-immunoglobulin-g4-positive-plasma-cells-and-elevated-serum-immunoglobulin-g4-levels
#11
Nabeel Azeem, Veeral Ajmera, Bilal Hameed, Neil Mehta
Immunoglobulin G4 (IgG4)-related disease is a fibroinflammatory systemic disorder with multiorgan involvement. Proximal bile duct involvement results in IgG4-related sclerosing cholangitis, which is characterized by a lymphoplasmacytic infiltrate with abundant IgG4-positive plasma cells and fibrosis. Differentiating between cholangiocarcinoma and IgG4-sclerosing cholangitis can present a diagnostic dilemma. We describe an unusual presentation of a hepatic mass meeting multiple criteria for IgG4-sclerosing cholangitis but was ultimately found to be cholangiocarcinoma...
April 2018: Hepatology Communications
https://www.readbyqxmd.com/read/29607610/recurrent-igg4-related-tubulointerstitial-nephritis-concurrent-with-chronic-active-antibody-mediated-rejection-a-case-report
#12
Rajni Chibbar, Glenda R Wright, Pouneh Dokouhaki, Sandi Dumanski, Bhanu Prasad, Michael Mengel, Lynn D Cornell, Ahmed Shoker
IgG4-related disease is a relatively newly described entity that can affect nearly any organ, including the kidneys, when it usually manifests as tubulointerstitial nephritis (IgG4-TIN). The diagnosis can be suggested by characteristic histological features, including an inflammatory infiltrate with increased IgG4 positive plasma cells associated with "storiform" fibrosis. Serum IgG4 is usually elevated. In the native kidney and other organs, there is typically a brisk response to treatment with immunosuppression...
April 1, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29606119/invasive-meningococcal-disease-due-to-a-non-capsulated-neisseria-meningitidis-strain-in-a-patient-with-igg4-related-disease
#13
Shun Kurose, Kyoko Onozawa, Hiroshi Yoshikawa, Kenichiro Yaita, Hideyuki Takahashi, Nobuyuki Shimono, Yoji Nagasaki
BACKGROUND: Invasive Meningococcal Disease (IMD) is a rare and critical disease in Japan. Most of these cases are caused by capsulated Neisseria meningitidis strains. Non-capsulated (non-typable) strains are considered relatively low-pathogenic and can colonize in the nasopharynx of healthy children and young adults. As far as could be ascertained, only twelve IMD cases due to non-capsulated strains have been reported in the literature. No clear risk factors could be identified in a literature review (unknown or immunocompetent, seven cases; C6 deficiency, three cases)...
April 2, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29584907/comment-on-igg4-related-disease-presenting-with-raised-serum-igg2-real-timeline-of-igg4-rd
#14
Andre Mattman, Luke Y C Chen, Grace van der Gugten, Alex Chin, Mollie Carruthers, Mari L DeMarco, Daniel T Holmes
No abstract text is available yet for this article.
March 23, 2018: Rheumatology
https://www.readbyqxmd.com/read/29584900/comment-on-igg4-related-disease-presenting-with-raised-serum-igg2-real-timeline-of-igg4-rd-reply
#15
Lisa Dunkley, Hardeep S Mudhar
No abstract text is available yet for this article.
March 23, 2018: Rheumatology
https://www.readbyqxmd.com/read/29584535/intracranial-hypertension-related-to-cerebral-venous-thrombosis-and-acute-ischemic-stroke-with-micro-infarcts-associated-with-igg4-related-disease
#16
Esme Ekizoglu, Oguzhan Coban, Cagri Ulukan, Duygu Gezen Ak, Erdinç Dursun, Erdem Tuzun, Betul Baykan
IgG4-related systemic disease (IgG4-RD) is characterized by an inflammatory reaction rich in IgG4-positive plasma cells, affecting multiple organs. This report describes a case who was diagnosed with IgG4-RD, having cerebral venous thrombosis and a subsequent acute ischemic stroke of undetermined cause. The 47-year-old woman presented with headache, visual disturbance and eyelid swelling and two years later she was admitted with acute attacks of mild left lower limb sensory-motor monoparesis. Indirect immunohistochemistry assay showed elevated level of IgG4, labeling neurons of the central nervous system, suggesting an immunological process possibly affecting vascular structures...
March 27, 2018: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29566870/infraorbital-nerve-involvement-on-magnetic-resonance-imaging-in-igg4-related-ophthalmic-disease-a-highly-suggestive-sign
#17
Augustin Lecler, Mathieu Zmuda, Romain Deschamps
No abstract text is available yet for this article.
April 2018: Ophthalmology
https://www.readbyqxmd.com/read/29566093/patterns-of-sensitization-to-inhalant-and-food-allergens-among-pediatric-patients-from-the-moscow-region-russian-federation
#18
Sergei Voloshin, Olga Smoldovskaya, Guzel Feyzkhanova, Alla Arefieva, Lyudmila Pavlushkina, Tatiana Filatova, Veronika Butvilovskaya, Marina Filippova, Yuri Lysov, Sergey Shcherbo, Alexander Makarov, Alla Rubina, Alexander Zasedatelev
The immunological profiles of human specific IgE (sIgE) and specific IgG4 (sIgG4) vary by genetic predisposition, living conditions in different geographical locations and patient's age. The aim of our study was to analyze sIgE and sIgG4 patterns and their age-dependent changes in patients from the Moscow region. For identifying sIgE and sIgG4 profiles the blood samples from 513 patients aged 6 months to 17 years who were showing symptoms of allergic diseases were analyzed using microarrays containing 31 allergens...
2018: PloS One
https://www.readbyqxmd.com/read/29562380/igg4-related-disease-of-the-hepatobiliary-tract-2-case-reports-and-review-of-the-literature
#19
J Spapen, A Reekmans, B Berghmans, S Debeuckelaere, P Buydens, L Trappeniers, B Van den Bossche, I Colle
IgG4-related disease is a rare inflammatory disorder that may mimic many infectious, malignant, and autoimmune conditions. The biliary tract is frequently involved, but hepatic lesions are rarely seen. Diagnosis is often delayed due to the absence of specific clinical and radiological signs, and the lack of an accurate diagnostic marker. Differential diagnosis includes cholangiocarcinoma, primary sclerosing cholangitis and intrinsic or metastatic liver disease. Corticosteroids are the cornerstone of therapy but treatment has not been standardized and relapse is common...
January 2018: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/29562281/an-unusual-manifestation-of-igg4-related-disease
#20
Roberta Priori, Bruno Lucchino, Bruna Cerbelli, Cristiano Alessandri, Valeria Bottaro, Alessio Zodda, Giulia D'Amati, Guido Valesini, Massimo Fusconi
No abstract text is available yet for this article.
March 19, 2018: Rheumatology
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