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https://www.readbyqxmd.com/read/28627468/a-novel-chalcone-derivative-lqfm064-induces-breast-cancer-cells-death-via-p53-p21-kit-and-pdgfra
#1
Bruna Lannuce Silva Cabral, Artur Christian Garcia da Silva, Renato Ivan de Ávila, Alane Pereira Cortez, Rangel Magalhães Luzin, Luciano Morais Lião, Eric de Souza Gil, Gérman Sanz, Boniek G Vaz, José R Sabino, Ricardo Menegatti, Marize Campos Valadares
This study shows the design, synthesis and antitumoral potential evaluation of a novel chalcone-like compound, (E)-3- (3, 5-di-ter-butyl-4-hydroxyphenyl)-1- (4-hydroxy-3-methoxyphenyl) prop-2-en-1-one [LQFM064) (4)], against human breast adenocarcinoma MCF7 cells. Some toxicological parameters were also investigated. LQFM064) (4) exhibited cytotoxic activity against MCF7 cells (IC50=21μM), in a concentration dependent-manner, and triggered significant changes in cell morphology and biochemical/molecular parameters, which are suggestive of an apoptosis inductor...
June 13, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28622826/gstp1-and-xrcc1-polymorphisms-and-dna-damage-in-agricultural-workers-exposed-to-pesticides
#2
Amal Saad-Hussein, Magda Noshy, Mona Taha, Haidan El-Shorbagy, Eman Shahy, Ebtesam A Abdel-Shafy
Pesticide exposure may be associated with increased risk of genotoxicity and carcinogenesis. These risks may be affected by polymorphisms of genes for glutathione transferase-dependent metabolism of pesticides and for DNA repair. We studied the prevalence of GSTP1 and XRCC1 polymorphisms and their possible correlation with DNA damage following prolonged pesticide exposure. DNA damage was estimated by the comet assay in peripheral blood samples from 51 pesticide-exposed workers and 50 controls. GSTP1 (105) and XRCC1 (399 and 194) genotypes were identified by restriction fragment length analysis...
July 2017: Mutation Research
https://www.readbyqxmd.com/read/28621814/identification-and-characterization-of-the-zebrafish-glutathione-s-transferase-pi-1
#3
Maryam S Abunnaja, Katsuhisa Kurogi, Yasir I Mohammed, Yoichi Sakakibara, Masahito Suiko, Ezdihar A Hassoun, Ming-Cheh Liu
Zebrafish has in recent years emerged as a popular vertebrate model for use in pharmacological and toxicological studies. While there have been sporadic studies on the zebrafish glutathione S-transferases (GSTs), the zebrafish GST gene superfamily still awaits to be fully elucidated. We report here the identification of 15 zebrafish cytosolic GST genes in NCBI GenBank database and the expression, purification, and enzymatic characterization of the zebrafish cytosolic GST Pi-1 (GSTP1). The cDNA encoding the zebrafish GSTP1 was cloned from a 3-month-old female zebrafish, expressed in Eschelichia coli host cells, and purified...
June 16, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28620445/unusual-gastrointestinal-and-cutaneous-toxicities-by-bleomycin-etoposide-and-cisplatin-a-case-report-with-pharmacogenetic-analysis-to-personalize-treatment
#4
Marzia Del Re, Tiziana Latiano, Leonardo Fidilio, Giuliana Restante, Franco Morelli, Evaristo Maiello, Romano Danesi
The standard treatment of testicular germ cell tumors is based on the combination of bleomycin, etoposide, and cisplatin (PEB). However, this treatment may be associated with severe adverse reactions, such as hematological and non-hematological toxicities. Here, we report a case of a patient suffering from severe PEB-related toxicities, to whom pharmacogenetic analyses were performed, comprising a panel of genes involved in PEB metabolism. The analysis revealed the presence of a complex pattern of polymorphisms in GSTP1, UGT1A1 (TA)6/7, UGT1A7, and ABCB1...
March 2017: EPMA Journal
https://www.readbyqxmd.com/read/28615972/single-nucleotide-polymorphisms-and-unacceptable-late-toxicity-in-breast-cancer-adjuvant-radiotherapy-a-case-report
#5
Grazia Lazzari, Maria Iole Natalicchio, Angela Terlizzi, Francesco Perri, Giovanni Silvano
BACKGROUND: There has recently been a strong interest in the inter-individual variation in normal tissue and tumor response to radiotherapy (RT), because tissue radiosensitivity seems to be under genetic control. Evidence is accumulating on the role of polymorphic genetic variants, such as single nucleotide polymorphisms (SNPs) that could influence normal tissue response after radiation. The most studied SNPs include those in genes involved in DNA repair (single- and double-strand breaks, and base excision) and those active in the response to oxidative stress...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28608594/melatonin-ameliorates-anxiety-and-depression-like-behaviors-and-modulates-proteomic-changes-in-triple-transgenic-mice-of-alzheimer-s-disease
#6
Lulin Nie, Gang Wei, Shengming Peng, Zhongsen Qu, Ying Yang, Qian Yang, Xinfeng Huang, Jianjun Liu, Zhixiong Zhuang, Xifei Yang
Alzheimer's disease (AD) is a devastating neurodegenerative disease accompanied by neuropsychiatric symptoms, such as anxiety and depression. The levels of melatonin decrease in brains of AD patients. The potential effect of melatonin on anxiety and depression behaviors in AD and the underlying mechanisms remain unclear. In this study, we treated 10-month-old triple transgenic mice of AD (3xTg-AD) with melatonin (10 mg/kg body weight/day) for 1 month and explored the effects of melatonin on anxiety and depression-like behaviors in 3xTg-AD mice and the protein expression of hippocampal tissues...
June 13, 2017: BioFactors
https://www.readbyqxmd.com/read/28603631/hepatic-expression-profiles-in-retroviral-infection-relevance-to-drug-hypersensitivity-risk
#7
Yat Yee Wong, Brian Johnson, Thomas C Friedrich, Lauren A Trepanier
HIV-infected patients show a markedly increased risk of delayed hypersensitivity (HS) reactions to potentiated sulfonamide antibiotics (trimethoprim/sulfamethoxazole or TMP/SMX). Some studies have suggested altered SMX biotransformation in HIV infection, but hepatic biotransformation pathways have not been evaluated directly. Systemic lupus erythematosus (SLE) is another chronic inflammatory disease with a higher incidence of sulfonamide HS, but it is unclear whether retroviral infection and SLE share risk factors for drug HS...
June 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28585914/glutathione-s-transferase-gene-polymorphisms-and-the-development-of-new-onset-diabetes-after-liver-transplant
#8
Zahra Musavi, Elham Moasser, Neda Zareei, Negar Azarpira, Ali Shamsaeefar
OBJECTIVES: The association between the glutathione S-transferase polymorphisms and the development of new-onset diabetes mellitus after liver transplant was studied. MATERIALS AND METHODS: Peripheral blood samples were collected from 106 liver transplant patients divided into 2 groups: 52 with new-onset diabetes mellitus and 54 without new-onset diabetes mellitus; 169 healthy individuals with no clinical evidence of diabetes mellitus were selected as a control group...
June 5, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28583046/influence-of-roasting-on-the-chemopreventive-potential-of-in-vitro-fermented-almonds-in-lt97-colon-adenoma-cells
#9
Wiebke Schlörmann, Sonja Fischer, Christian Saupe, Tülin Dinc, Stefan Lorkowski, Michael Glei
The consumption of almonds may contribute to the prevention of colon cancer due to their unique composition of health promoting compounds. Since almonds are often consumed roasted, the impact of different roasting (R) conditions (R1 = 139.2 °C/25 min, R2 = 161.5 °C/20 min and R3 = 170.8 °C/15 min) on chemopreventive effects of in vitro-fermented almonds was analysed in LT97 colon adenoma cells. Fermentation supernatants (FS) of raw and roasted almonds had no genotoxic effects. FS obtained from raw or mildly roasted almonds (R1) significantly increased mRNA levels of CAT (4...
June 5, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28581641/clk1-regulated-aerobic-glycolysis-is-involved-in-gliomas-chemoresistance
#10
Li Zhang, Huicui Yang, Wenbin Zhang, Zhongqin Liang, Qiang Huang, Guoqiang Xu, Xuechu Zhen, Long Tai Zheng
Chemoresistance remains a major challenge for the treatment of glioma. In the present study, we investigated the role of Clk1, which encodes an enzyme that is necessary for ubiquinone biosynthesis in glioma chemoresistance in vitro. The results showed that Clk1 was highly expressed in GL261 mouse glioma cells which were most sensitive to BCNU while was expressed in BCNU resistant cells such as glioma cancer stem cells: T98G, U87MG and U251 glioma cells at low levels. Knockdown of Clk1 in GL261 glioma cells significantly reduced BCNU- or cisplatin- induced cell apoptosis whereas the proliferative activity and the expression of multi-drug resistance -related genes including MDR1, MGMT and GSTP1 were not changed...
June 5, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28572675/predictive-assessment-in-pharmacogenetics-of-glutathione-s-transferases-genes-on-efficacy-of-platinum-based-chemotherapy-in-non-small-cell-lung-cancer-patients
#11
Huan Ye, Meiqin Shao, Xiaohong Shi, Lifeng Wu, Bing Xu, Qiang Qu, Jian Qu
The influences of glutathione s-transferase P1, M1, and T1 variants on the efficacy of platinum-based chemotherapy in non-small cell lung cancer (NSCLC) patients were inconsistent in previous studies. Our meta-analysis enrolled 31 publications including 5712 patients and provided more convincing and reliable conclusions. Results showed that GSTP1 IIe105Val IIe/Val and Val/Val Asian patients were more likely to have better response rates compared to IIe/IIe patients (odds ratio (OR) = 1.592, 95% confidence intervals (CIs), 1...
June 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28561194/impact-of-the-ile105val-polymorphism-of-the-glutathione-s-transferase-p1-gstp1-gene-on-obesity-and-markers-of-cardiometabolic-risk-in-young-adult-population
#12
E O Chielle, A Trott, B da Silva Rosa, J N Casarin, P C Fortuna, I B M da Cruz, M B Moretto, R N Moresco
The aim of the study was to investigate the association between Glutathione S-transferase P1 (GSTP1) gene polymorphism with obesity and markers of cardiometabolic risk. A cross-sectional study was carried out in individuals aged≥18 and ≤30 years. The study included 54 normal weight, 27 overweight and 68 obese volunteers. Anthropometric measurements and biochemical parameters were evaluated, the DNA was extracted from blood samples and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to measure GSTP1 Ile(105)Val gene polymorphism of the study participants...
May 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28550240/the-role-of-gst-polymorphism-in-reperfusion-induced-oxidative-stress-inflammatory-responses-and-clinical-complications-after-surgical-and-percutaneous-coronary-intervention
#13
Örs Pintér, Péter Hardi, Tibor Nagy, Balázs Gasz, Viktoria Kovács, Endre Arató, László Sínay, László Lénárd, Gábor Jancsó
BACKGROUND: Patients having coronary artery disease treated by coronary bypass or PCI procedure are exposed to tissue damage because of the phenomenon called reperfusion injury. Reperfusion injury can be characterized/monitored by oxidative stress parameters, inflammatory markers and by post-operative complication rate. OBJECTIVE: Beyond the obvious factors determining its severity (affected myocardial mass, ischaemic time, collateral circulation etc.) we examined the GST enzyme group's most cardio selective member, GSTP1 and its genetic polymorphism if there is any genetically determined preventive effect on the above-mentioned parameters...
May 24, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28527972/genetic-and-epigenetic-alterations-in-meningiomas
#14
REVIEW
Vasiliki Galani, Evangeli Lampri, Anna Varouktsi, George Alexiou, Antigoni Mitselou, Athanasios P Kyritsis
Meningiomas originate from the arachnoid layer of the meninges and divided histologically into three grades: benign (grade I), atypical (grade II), and malignant meningiomas (grade III). Genetic alterations in grade I meningiomas include frequent deletions of chromosomal locus 22q12 and NF2 gene mutations and uncommon somatic SMARCB1 and SMARCE1gene mutations; In grade II meningiomas, chromosomal losses occur on 1p, 22q, 14q, 18q, 10, and 6q, and gains on 20q, 12q, 15q, 1q, 9q, and 17q; In grade III meningiomas, losses have been recognized on 6q, 10, and 14q and alterations of PTEN, CDKN2A and CDKN2B genes...
July 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28524770/detection-of-promoter-dna-methylation-of-apc-dapk-and-gstp1-genes-in-tissue-biopsy-and-matched-serum-of-advanced-stage-lung-cancer-patients
#15
Ashraf Ali, Sachin Kumar, Vinod Kumar Kakaria, Anant Mohan, Kalpana Luthra, Ashish Dutt Upadhyay, Randeep Guleria
Promoter DNA hypermethylation of APC, DAPK, and GSTP1 genes was evaluated in biopsy and matched serum of 160 lung cancer patients and 70 controls. In biopsy, 83.1, 83.1, and 78.1% of lung cancer patients and 72.9, 70, and 70% of controls, while in serum, 52.5, 30.6, and 65.6% of lung cancer patients and 14.3, 18.6, and 30% of controls were positive for APC, DAPK, and GSTP1 hypermethylation respectively. We couldn't find any significant role of DNA hypermethylation in lung cancer. However, long follow-up of methylation positive controls will be required to confirm its role for the prediction of lung cancer...
May 19, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28495910/oxidative-imbalance-and-kidney-damage-in-spontaneously-hypertensive-rats-activation-of-extrinsic-apoptotic-pathway
#16
Daniele La Russa, Elvira Brunelli, Daniela Pellegrino
In both humans and animals, essential hypertension acts as a risk factor for subclinical kidney damage and precedes renal dysfunction. Several lines of evidence indicate that hypertension and oxidative stress are closely related. The increase in vascular oxidative stress plays a key role in the pathophysiological consequences of hypertension, including kidney disease. Our study examined this issue in SHR, a reliable model of essential hypertension. We used SHR 20 weeks-old when hypertension is stably developed, vascular remodeling started, but kidney function is preserved...
May 11, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28495476/studies-on-diagnostic-biomarkers-and-therapeutic-mechanism-of-alzheimer-s-disease-through-metabolomics-and-hippocampal-proteomics
#17
Weiwei Lin, Jianmei Zhang, Yanmeng Liu, Ruijun Wu, Haisong Yang, Xiaobo Hu, Xiaomei Ling
Alzheimer's disease (AD) is the main cause of dementia, but precise diagnosis and treatment are not sufficient so far. The purpose of this study is to develop biomarkers and therapeutic targets for diagnosis and better understanding of AD. As a result, lysophosphatidylcholine and intermediates of sphingolipid metabolism including sphinganine-1-phosphate, sphingosine-1-phosphate, sphingomyelin, and sphingosine in plasma were annotated as potential biomarkers by using UPLC-Q-TOF-MS and UHPLC-Q-Exactive-MS. Besides, glutathione S-transferases (GSTs) including GstA3, Gstm1, Gstm5, Gstm3, Gstk1 and Gstp1 were significantly enhanced in AD hippocampus by using label free nano-LC-MS/MS...
May 8, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28469982/estrogen-inhibits-starvation-induced-apoptosis-in-osteocytes-by-a-redox-independent-process-involving-association-of-jnk-and-glutathione-s-transferase-p1-1
#18
Vladana Domazetovic, Filippo Fontani, Gemma Marcucci, Teresa Iantomasi, Maria Luisa Brandi, Maria Teresa Vincenzini
Estrogen deficiency causes bone loss as a result of microdamage, oxidative stress, and osteocyte apoptosis. A relationship between oxidative stress-induced apoptosis, c-Jun N-terminal kinase (JNK) activation, and expression of factors involved in bone remodeling has been demonstrated in osteocytes. However, the molecular regulation of these events in osteocytes treated with 17β-estradiol (17β-E2) remains unexplored. The MLO-Y4 murine osteocyte-like cell line was used as a model to study starvation-induced apoptosis and ROS production during 17β-E2 treatment...
May 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/28464886/a-lung-cancer-risk-classifier-comprising-genome-maintenance-genes-measured-in-normal-bronchial-epithelial-cells
#19
Jiyoun Yeo, Erin L Crawford, Xiaolu Zhang, Sadik Khuder, Tian Chen, Albert Levin, Thomas M Blomquist, James C Willey
BACKGROUND: Annual low dose CT (LDCT) screening of individuals at high demographic risk reduces lung cancer mortality by more than 20%. However, subjects selected for screening based on demographic criteria typically have less than a 10% lifetime risk for lung cancer. Thus, there is need for a biomarker that better stratifies subjects for LDCT screening. Toward this goal, we previously reported a lung cancer risk test (LCRT) biomarker comprising 14 genome-maintenance (GM) pathway genes measured in normal bronchial epithelial cells (NBEC) that accurately classified cancer (CA) from non-cancer (NC) subjects...
May 2, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28461312/knockdown-of-host-antioxidant-defense-genes-enhances-the-effect-of-glucantime-on-intracellular-leishmania-braziliensis-in-human-macrophages
#20
Jair Téllez, Ibeth Romero, Maurilio José Soares, Mario Steindel, Alvaro José Romanha
Leishmaniasis is a neglected tropical disease affecting millions of people worldwide and represents a major public health problem. Information on protein expression patterns and functional roles within the context of Leishmania-infected human monocyte-derived macrophages (MDMs) under drug treatment conditions are essential to understand the role of these cells in leishmaniasis treatment. We analyzed functional changes in expression of human MDM genes and proteins during in vitro infection by Leishmania braziliensis and treatment with Glucantime (Sb(V)) using quantitative polymerase chain reaction (qPCR) arrays, western blotting, confocal microscopy and short-interfering RNA (siRNA) human gene-inhibition assays...
May 1, 2017: Antimicrobial Agents and Chemotherapy
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