Qiwen Jin, Sang Lin, Xixia Chen, Yuetong Xu, Xiaolan Tian, Linrong He, Wei Jiang, Fang Chen, Xiaoming Shu, Xin Lu, Qinglin Peng, Guochun Wang
OBJECTIVE: To depict the clinical panorama of spontaneous pneumomediastinum (SPM) in anti-MDA5 antibody-positive dermatomyositis (anti-MDA5+ DM). METHODS: A total of 1352 patients with idiopathic inflammatory myopathy (IIM), including 384 anti-MDA5+ DM patients were retrospectively enrolled. The clinical profiles of anti-MDA5+ DM-associated SPM were analyzed. RESULTS: We identified that 9.4 % (36/384) of anti-MDA5+ DM patients were complicated with SPM, which was significantly higher than that of non-anti-MDA5+ DM and other IIM subtypes (P all <0...
April 2024: Seminars in Arthritis and Rheumatism