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Kyneurenine

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https://www.readbyqxmd.com/read/18929841/induction-of-indoleamine-2-3-dioxygenase-in-livers-following-hepatectomy-prolongs-survival-of-allogeneic-hepatocytes-after-transplantation
#1
Y C Lin, S Goto, C Tateno, T Nakano, Y F Cheng, B Jawan, Y H Kao, L W Hsu, C Y Lai, K Yoshizato, C L Chen
OBJECTIVES: Indoleamine 2,3-dioxygenase (IDO), which catalyzes the breakdown of tryptophan into kyneurenine, has immunologic significance for the induction of maternal tolerance and liver allograft tolerance by inhibiting T-cell activation. In the present study, we compared survival of syngeneic or allogeneic hepatocytes in livers with or without hepatectomy. Subsequently, we investigated gene expression and localization of IDO in the recipient liver. METHODS: DA and Fisher 344 rats were used in the following experimental groups: group 1, DA hepatocytes transplanted into hepatectomized Fisher 344 rats; group 2, Fisher 344 hepatocytes transplanted into hepatectomized Fisher 344 rats; group 3, DA hepatocytes transplanted into nonhepatectomized Fisher 344 rats; and group 4, Fisher 344 hepatocytes transplanted into nonhepatectomized Fisher 344 rats...
October 2008: Transplantation Proceedings
https://www.readbyqxmd.com/read/11812742/indoleamine-2-3-dioxygenase-expression-in-transplanted-nod-islets-prolongs-graft-survival-after-adoptive-transfer-of-diabetogenic-splenocytes
#2
Angela M Alexander, Megan Crawford, Suzanne Bertera, William A Rudert, Osamu Takikawa, Paul D Robbins, Massimo Trucco
Indoleamine 2,3-dioxygenase (IDO) catalyzes the breakdown of the amino acid tryptophan into kyneurenine. It has been shown that IDO production by placental trophoblasts prevents the attack of maternal T-cells activated in response to the paternal HLA alleles expressed by the tissues of the fetus. In this article, we show that adenoviral gene transfer of IDO to pancreatic islets can sufficiently deplete culture media of tryptophan and consequently inhibit the proliferation of T-cells in vitro. Experiments in vivo have also demonstrated that transplantation of IDO-expressing islets from prediabetic NOD mouse donors into NODscid recipient mice is associated with a prolongation in islet graft survival after adoptive transfer of NOD diabetogenic T-cells...
February 2002: Diabetes
https://www.readbyqxmd.com/read/7883047/molecular-cloning-and-expression-of-a-cdna-for-human-kidney-cysteine-conjugate-beta-lyase
#3
S Perry, H Harries, C Scholfield, T Lock, L King, G Gibson, P Goldfarb
Kidney cysteine conjugate beta-lyase (glutamine transaminase K, kyneurenine aminotransferase, EC 2.6.1.64) metabolises the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites which can produce nephrotoxicity and neurotoxicity in experimental animals and man. Using a combination of hybridisation screening and PCR techniques we have isolated a full-length cDNA for human kidney cysteine conjugate beta-lyase. Comparison of the deduced amino acid sequence with that of the rat enzyme indicated an 82% overall similarity, with 90% similarity around the pyridoxal phosphate binding site, many of the changes being conservative in nature...
March 6, 1995: FEBS Letters
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