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Robert P. Hasserjian

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https://www.readbyqxmd.com/read/27727468/molecular-testing-for-jak2-mpl-and-calr-in-myeloproliferative-neoplasms
#1
Daniel Xia, Robert P Hasserjian
Polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) are myeloproliferative neoplasms characterized by recurrent somatic mutations in JAK2, CALR, and MPL. This short review addresses (1) the spectrum of mutations seen in PV, ET, and PMF, (2) the emerging genotype-phenotype correlations, (3) the current role of molecular testing in disease classification and management, and (4) several important considerations for selecting an appropriate molecular test. In our view, sequential testing algorithms and simultaneous assessment of multiple mutations by next-generation sequencing are both valid approaches to testing...
December 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27554207/primary-lymphoma-of-bone-in-the-pediatric-and-young-adult-population
#2
Karen M Chisholm, Robert S Ohgami, Brent Tan, Robert P Hasserjian, Olga K Weinberg
Primary lymphoma of bone (PLB) accounts for 3-7% of primary neoplasms of bone and must be distinguished from more common bone tumors in the pediatric population such as osteosarcoma, Ewing sarcoma, and other small round blue cell tumors. In this study, pathology databases from four institutions were queried for PLB in individuals 1-21 years old. A total of 54 cases of PLB were identified, including 41 diffuse large B cell lymphomas (DLBCL, 76%), 8 B lymphoblastic lymphomas (BLL, 15%), 3 anaplastic large cell lymphomas (ALCL, 6%), and 2 low grade follicular lymphomas (FL, 4%)...
August 20, 2016: Human Pathology
https://www.readbyqxmd.com/read/27443511/acute-erythroid-leukemia-with-20-bone-marrow-blasts-is-clinically-and-biologically-similar-to-myelodysplastic-syndrome-with-excess-blasts
#3
Sa A Wang, Keyur P Patel, Olga Pozdnyakova, Jie Peng, Zhuang Zuo, Paola Dal Cin, David P Steensma, Robert P Hasserjian
In acute erythroleukemia, erythroid/myeloid subtype, blasts usually comprise 5-19% of total bone marrow cells, similar to the myelodysplastic syndrome subtype refractory anemia with excess blasts; recent studies have raised the question if acute erythroleukemia should be considered as a myelodysplastic syndrome subtype. We reviewed 77 de novo acute erythroleukemia and 279 de novo refractory anemia with excess blasts from three large medical centers. Compared to refractory anemia with excess blasts, acute erythroleukemia patients had higher total bone marrow blasts, lower platelets, hemoglobin, and absolute neutrophil counts, with more patients being assigned a very-poor-karyotype risk and very-high Revised International Prognostic Scoring System score...
October 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27419920/the-immunophenotypic-spectrum-of-primary-mediastinal-large-b-cell-lymphoma-reveals-prognostic-biomarkers-associated-with-outcome
#4
Jacob R Bledsoe, Robert A Redd, Robert P Hasserjian, Jacob D Soumerai, Ha T Nishino, Daniel F Boyer, Judith A Ferry, Lawrence R Zukerberg, Nancy Lee Harris, Jeremy S Abramson, Aliyah R Sohani
Primary mediastinal large B-cell lymphoma (PMBL) is a distinct subtype of diffuse large B-cell lymphoma (DLBCL) that shows overlap with classical Hodgkin lymphoma (CHL) and a favorable prognosis compared to mediastinal gray-zone lymphoma (MGZL). We performed immunohistochemistry on initial diagnostic specimens of 49 cases of uniformly treated PMBL to determine the frequency and clinical significance of expression of antigens commonly seen in CHL and MGZL, along with markers previously shown to be prognostic in DLBCL, not otherwise specified...
October 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27389864/clinicopathologic-evaluation-of-cytopenic-patients-with-isolated-trisomy-8-a-detailed-comparison-between-idiopathic-cytopenia-of-unknown-significance-and-low-grade-myelodysplastic-syndrome
#5
Kseniya Petrova-Drus, Robert Hasserjian, Olga Pozdnyakova, Paola Dal Cin, Susan Mathew, Elizabeth Margolskee, Attilio Orazi, Julia T Geyer
The significance of an isolated trisomy 8 (+8) in the diagnosis of myelodysplastic syndrome (MDS) is not well established. It is common in MDS, but is not considered as an MDS-defining abnormality in the absence of morphologic dysplasia. We evaluated two groups of patients with isolated +8 and either low-grade MDS (LG-MDS) or idiopathic cytopenia of undetermined significance (ICUS). At presentation, ICUS patients had a lower platelet count (85.0 vs 163.5 × 10(9) cells/L; p = 0.02), while MDS patients had more frequent incidence of isolated anemia (64% vs 0%, p = 0...
July 7, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27387988/assessment-of-myeloid-and-monocytic-dysplasia-by-flow-cytometry-in-de-novo-aml-helps-define-an-aml-with-myelodysplasia-related-changes-category
#6
Olga K Weinberg, Robert P Hasserjian, Betty Li, Olga Pozdnyakova
AIMS: In recent years, multiparameter flow cytometry has been increasingly recognised as an important tool in diagnosis of myelodysplastic syndrome and acute myeloid leukaemia (AML). Assessment of myeloid and monocytic 'immunophenotypic' dysplasia by flow cytometry in de novo AML has not been evaluated. METHODS: 97 cases of de novo AML cases were identified and reviewed by three hematopathologists. 'Immunophenotypic' dysplasia was assessed on blasts, monocytes and granulocytes by mean fluorescence intensity...
July 7, 2016: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27325104/pediatric-type-nodal-follicular-lymphoma-a-biologically-distinct-lymphoma-with-frequent-mapk-pathway-mutations
#7
Abner Louissaint, Kristian T Schafernak, Julia T Geyer, Alexandra E Kovach, Mahmoud Ghandi, Dita Gratzinger, Christine G Roth, Christian N Paxton, Sunhee Kim, Chungdak Namgyal, Ryan Morin, Elizabeth A Morgan, Donna S Neuberg, Sarah T South, Marian H Harris, Robert P Hasserjian, Ephraim P Hochberg, Levi A Garraway, Nancy Lee Harris, David M Weinstock
Pediatric-type nodal follicular lymphoma (PTNFL) is a variant of follicular lymphoma (FL) characterized by limited-stage presentation and invariably benign behavior despite often high-grade histological appearance. It is important to distinguish PTNFL from typical FL in order to avoid unnecessary treatment; however, this distinction relies solely on clinical and pathological criteria, which may be variably applied. To define the genetic landscape of PTNFL, we performed copy number analysis and exome and/or targeted sequencing of 26 PTNFLs (16 pediatric and 10 adult)...
August 25, 2016: Blood
https://www.readbyqxmd.com/read/27174585/targeted-next-generation-sequencing-identifies-a-subset-of-idiopathic-hypereosinophilic-syndrome-with-features-similar-to-chronic-eosinophilic-leukemia-not-otherwise-specified
#8
Sa A Wang, Wayne Tam, Albert G Tsai, Daniel A Arber, Robert P Hasserjian, Julia T Geyer, Tracy I George, David R Czuchlewski, Kathryn Foucar, Heesun J Rogers, Eric D Hsi, B Bryan Rea, Adam Bagg, Paola Dal Cin, Chong Zhao, Todd W Kelley, Srdan Verstovsek, Carlos Bueso-Ramos, Attilio Orazi
The distinction between chronic eosinophilic leukemia, not otherwise specified and idiopathic hypereosinophilic syndrome largely relies on clonality assessment. Prior to the advent of next-generation sequencing, clonality was usually determined by cytogenetic analysis. We applied targeted next-generation sequencing panels designed for myeloid neoplasms to bone marrow specimens from a cohort of idiopathic hypereosinophilic syndrome patients (n=51), and assessed the significance of mutations in conjunction with clinicopathological features...
August 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27144366/small-cell-predominant-extranodal-nk-t-cell-lymphoma-nasal-type-clinicopathological-analysis-of-a-series-of-cases-diagnosed-in-a-western-population
#9
Penelope A McKelvie, Fina Climent, Gregor Krings, Robert P Hasserjian, Jeremy S Abramson, Ben Z Pilch, Nancy Lee Harris, Judith A Ferry, Lawrence R Zukerberg, Aliyah R Sohani
AIMS: Extranodal NK/T cell lymphoma, nasal type (ENKTCL) is usually composed of medium- to large-sized lymphoid cells showing prominent angiotrophism and tumour cell necrosis. We report 13 cases composed predominantly of small lymphocytes diagnosed in the United States and Western Europe. METHODS AND RESULTS: Patients included seven females and six males aged 17-75 years. Ten presented with sinonasal and three with buccal disease. Nine had stage IE/IIE and four had stage IV disease...
October 2016: Histopathology
https://www.readbyqxmd.com/read/27124944/pure-erythroid-leukemia-and-erythroblastic-sarcoma-evolving-from-chronic-myeloid-neoplasms
#10
Hongmei Li, Robert P Hasserjian, Steven H Kroft, Alexandra M Harrington, Susan E Wheaton, Alex Pildain, Mark D Ewalt, Dita Gratzinger, Paul Hosking, Horatiu Olteanu
OBJECTIVES: Pure erythroid leukemia (PEL) is an extremely rare entity that may, even more rarely, evolve from a preexisting chronic myeloid neoplasm (CMN); there is minimal literature regarding this latter phenomenon. METHODS: We describe 14 patients with PEL that represented progression from a preexisting myelodysplastic syndrome (MDS, n = 8) or myeloproliferative neoplasm (MPN, n = 6), three of which manifested as erythroblastic sarcoma (EBS), a rare entity...
April 2016: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/26940274/genetic-testing-in-acute-myeloid-leukemia-and-myelodysplastic-syndromes
#11
REVIEW
Valentina Nardi, Robert P Hasserjian
Cytogenetic analysis of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) is essential for disease diagnosis, classification, prognostic stratification, and treatment guidance. Molecular genetic analysis of CEBPA, NPM1, and FLT3 is already standard of care in patients with AML, and mutations in several additional genes are assuming increasing importance. Mutational analysis of certain genes, such as SF3B1, is also becoming an important tool to distinguish subsets of MDS that have different biologic behaviors...
March 2016: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/26839191/erythroleukemia-and-its-differential-diagnosis
#12
Robert P Hasserjian
Acute erythroid leukemias encompass 2 main subtypes: acute erythroleukemia (erythroid/myeloid subtype) and pure erythroid leukemia. This article reviews the main clinicopathologic features of the acute erythroid leukemias and the criteria used to diagnose them. In this article, the differential diagnosis between acute erythroid leukemias and their mimics is discussed and helpful morphologic clues and diagnostic tests that help arrive at the correct diagnosis are provided. The appropriate application of diagnostic criteria, including ancillary testing, such as immunophenotyping, cytogenetics, and molecular genetic testing, is essential to categorize bone marrow erythroid proliferations...
December 2013: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/26637736/reclassifying-myelodysplastic-syndromes-what-s-where-in-the-new-who-and-why
#13
REVIEW
Daniel A Arber, Robert P Hasserjian
A revision to the 4th edition of the WHO Classification of myelodysplastic syndromes (MDSs), originally published in 2008, is expected in mid-2016. Based on recommendations of a Clinical Advisory Committee, the revision will aim to incorporate new discoveries in MDS that impact existing disease categories. Although the basic diagnostic principles of the WHO classification remain unchanged, several changes to the classification are proposed. All revisions are considered preliminary until the actual publication of the monograph and online document...
2015: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/26397325/diagnostic-yield-of-ct-guided-percutaneous-transthoracic-needle-biopsy-for-diagnosis-of-anterior-mediastinal-masses
#14
Milena Petranovic, Matthew D Gilman, Ashok Muniappan, Robert P Hasserjian, Subba R Digumarthy, Victorine V Muse, Amita Sharma, Jo-Anne O Shepard, Carol C Wu
OBJECTIVE: The purpose of this study was to evaluate the diagnostic yield and accuracy of CT-guided percutaneous biopsy of anterior mediastinal masses and assess prebiopsy characteristics that may help to select patients with the highest diagnostic yield. MATERIALS AND METHODS: Retrospective review of all CT-guided percutaneous biopsies of the anterior mediastinum conducted at our institution from January 2003 through December 2012 was performed to collect data regarding patient demographics, imaging characteristics of biopsied masses, presence of complications, and subsequent surgical intervention or medical treatment (or both)...
October 2015: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/26331834/detection-of-dual-idh1-and-idh2-mutations-by-targeted-next-generation-sequencing-in-acute-myeloid-leukemia-and-myelodysplastic-syndromes
#15
Mia Y Platt, Amir T Fathi, Darrell R Borger, Andrew M Brunner, Robert P Hasserjian, Leonora Balaj, Amy Lum, Stephen Yip, Dora Dias-Santagata, Zongli Zheng, Long P Le, Timothy A Graubert, A John Iafrate, Valentina Nardi
Studies in myeloid neoplasms have described recurrent IDH1 and IDH2 mutations as primarily mutually exclusive. Over a 6-month period of clinical testing with a targeted next-generation sequencing assay, we evaluated 92 patients with acute myeloid leukemia, myelodysplastic syndrome, and chronic myelomonocytic leukemia and identified a subset of 21 patients (23%) who harbored mutations in either IDH1 or IDH2. Of the 21 patients with IDH mutations, 4 (19%) were found to have single nucleotide variants in both IDH1 and IDH2...
November 2015: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/26293512/myelodysplastic-syndromes-following-therapy-with-hypomethylating-agents-hmas-development-of-acute-erythroleukemia-may-not-influence-assessment-of-treatment-response
#16
Jie Peng, Robert P Hasserjian, Guilin Tang, Keyur P Patel, Maitrayee Goswami, Elias J Jabbour, Guillermo Garcia-Manero, L Jeffrey Medeiros, Sa A Wang
This study followed 28 patients with myelodysplastic syndromes (MDS) who showed a rise of bone marrow (BM) erythroids to ≥ 50% following three cycles (1-60) of hypomethylating agent (HMA) therapy. If BM blasts were calculated as a percentage of non-erythroids, 12 (42.9%) patients met the diagnostic criteria for acute erythroleukemia, erythroid/myeloid (AEL). However, none of the patients showed clonal cytogenetic evolution or new mutations. When compared to 47 de novo AEL patients, these 12 patients were less anemic and thrombocytopenic, had less complex karyotypes (p = 0...
2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/26220865/prior-cytopenia-predicts-worse-clinical-outcome-in-acute-myeloid-leukemia
#17
Amelia Huck, Olga Pozdnyakova, Andrew Brunner, John M Higgins, Amir T Fathi, Robert P Hasserjian
The prognosis of acute myeloid leukemia (AML) is influenced by both disease-intrinsic and patient-related factors. In particular, AML following myelodysplastic syndrome (MDS) (AML with myelodysplasia-related changes, AML-MRC) has a poor prognosis. We hypothesized that patients with cytopenias prior to AML, but no known prior MDS, may share biologic features with AML-MRC. We evaluated 140 AML patients without prior MDS who had complete blood count (CBC) data available 6-36 months prior to their diagnosis. Cytopenia, defined as clinically unexplained thrombocytopenia or macrocytic anemia, was present in 29/140 (21%) patients...
October 2015: Leukemia Research
https://www.readbyqxmd.com/read/26071461/acute-erythroleukemias-acute-megakaryoblastic-leukemias-and-reactive-mimics-a-guide-to-a-number-of-perplexing-entities
#18
REVIEW
Sa A Wang, Robert P Hasserjian
OBJECTIVES: At the 2013 Society for Hematopathology/European Association for Hematopathology Workshop, 36 cases were submitted to the session that covered acute erythroid leukemia (AEL), acute megakaryoblastic leukemia (AMKL), and reactive mimics. METHODS: Cases were reviewed by the session chairs and workshop panel to reach a consensus diagnosis. RESULTS: For acute erythroleukemia, erythroid/myeloid type, discussion acknowledged overlapping features between AEL and myelodysplastic syndromes...
July 2015: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/25975285/reproducibility-and-prognostic-significance-of-morphologic-dysplasia-in-de-novo-acute-myeloid-leukemia
#19
Olga K Weinberg, Olga Pozdnyakova, Federico Campigotto, Daniel J DeAngelo, Richard M Stone, Donna Neuberg, Robert P Hasserjian
The 2008 WHO classification of acute myeloid leukemia includes a category of acute myeloid leukemia with myelodysplasia-related changes; however, the significance of multilineage dysplasia alone is controversial and its reproducibility has not been evaluated in acute myeloid leukemia. We performed an in-depth analysis of morphologic dysplasia in 159 de novo acute myeloid leukemia cases lacking myelodysplasia-related cytogenetic abnormalities. Using the 2008 WHO criteria, there were 89 acute myeloid leukemia-not otherwise specified (56%) and 43 acute myeloid leukemia with myelodysplasia-related changes (27%), while 27 cases were ambiguous as to myelodysplasia-related changes status due to limited maturing cells (acute myeloid leukemia-not evaluable, 17%)...
July 2015: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/25973391/acute-myeloid-leukemia-in-a-patient-with-constitutional-47-xxy-karyotype
#20
Marla M Jalbut, Aliyah R Sohani, Paola Dal Cin, Robert P Hasserjian, Jenna A Moran, Andrew M Brunner, Amir T Fathi
Klinefelter syndrome (KS), a 47,XXY chromosomal abnormality, has been shown to be associated with a number of malignancies, but has not been linked to acute leukemias to date. We present a case of a 54-year-old male diagnosed with acute myeloid leukemia (AML) with monocytic differentiation, whose cytogenetic and subsequent FISH analyses revealed a constitutional 47,XXY karyotype. We also review and discuss relevant prior literature.
2015: Leukemia Research Reports
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