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https://www.readbyqxmd.com/read/27802063/in-silico-analysis-of-candidate-proteins-sharing-homology-with-streptococcus-agalactiae-proteins-and-their-role-in-male-infertility
#1
Rajeshwari Parida, Luna Samanta
: Leukocytospermia is a physiologic condition defined as human semen with a leukocyte count of >1 x 10(6) cells/ml that is often correlated with male infertility. Moreover, bacteriospermia has been associated with leukocytospermia ultimately leading to male infertility. We have found that semen samples with >1 x 10(6)/ml leukocytes and/or bacteriospermia have oxidative predominance as evidenced by augmented protein carbonyl and lipid peroxidation status of the semen which is implicated in sperm dysfunction...
November 1, 2016: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/27729200/towards-improved-drug-allergy-alerts-multidisciplinary-expert-recommendations
#2
EDITORIAL
Maxim Topaz, Foster Goss, Kimberly Blumenthal, Kenneth Lai, Diane L Seger, Sarah P Slight, Paige G Wickner, George A Robinson, Kin Wah Fung, Robert C McClure, Shelly Spiro, Warren W Acker, David W Bates, Li Zhou
No abstract text is available yet for this article.
January 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/27701750/assessment-of-respiratory-distress-by-the-roth-score
#3
Ehud Chorin, Allison Padegimas, Ofer Havakuk, Edo Y Birati, Yacov Shacham, Anat Milman, Guy Topaz, Nir Flint, Gad Keren, Ori Rogowski
INTRODUCTION: Health care demand is increasing due to greater longevity of patients with chronic comorbidities. This increasing demand is occurring in a setting of resource scarcity. To address these changes, high-value care initiatives, such as telemedicine, are valuable resource-preservation strategies. This study introduces the Roth score as a telemedicine tool that uses patient counting times to accurately risk-stratify dyspnea severity in terms of hypoxia. HYPOTHESIS: The Roth score has correlation with dyspnea severity...
October 4, 2016: Clinical Cardiology
https://www.readbyqxmd.com/read/27692763/a-transapical-to-aorta-double-lumen-cannula-based-neonate-left-ventricular-assist-device-efficiently-unloads-the-left-ventricle-in-neonate-lambs
#4
Cheng Zhou, Dongfang Wang, Cherry Ballard-Croft, Guangfeng Zhao, Hassan K Reda, Stephen Topaz, Joseph Zwischenberger
OBJECTIVE: We are developing a transapical-to-aorta double lumen cannula (TAA DLC) for a less-invasive/more dependable neonatal left ventricular assist device. METHODS: The 18-Fr TAA DLC prototypes were bench tested and evaluated for 6 hours in neonate lambs (n = 6, 7.7-10 kg). The cardiac apex was exposed through a left anterolateral thoracotomy through the sixth intercostal space. The TAA DLC was inserted through a mattress stitch on apex, passing LV-aortic valve, into the ascending aorta with insertion/deployment guided by pressure waveform...
August 31, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27668855/automated-identification-of-wound-information-in-clinical-notes-of-patients-with-heart-diseases-developing-and-validating-a-natural-language-processing-application
#5
Maxim Topaz, Kenneth Lai, Dawn Dowding, Victor J Lei, Anna Zisberg, Kathryn H Bowles, Li Zhou
BACKGROUND: Electronic health records are being increasingly used by nurses with up to 80% of the health data recorded as free text. However, only a few studies have developed nursing-relevant tools that help busy clinicians to identify information they need at the point of care. OBJECTIVE: This study developed and validated one of the first automated natural language processing applications to extract wound information (wound type, pressure ulcer stage, wound size, anatomic location, and wound treatment) from free text clinical notes...
September 19, 2016: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/27628125/studying-associations-between-heart-failure-self-management-and-rehospitalizations-using-natural-language-processing
#6
Maxim Topaz, Kavita Radhakrishnan, Suzanne Blackley, Victor Lei, Kenneth Lai, Li Zhou
This study developed an innovative natural language processing algorithm to automatically identify heart failure (HF) patients with ineffective self-management status (in the domains of diet, physical activity, medication adherence, and adherence to clinician appointments) from narrative discharge summary notes. We also analyzed the association between self-management status and preventable 30-day hospital readmissions. Our natural language system achieved relatively high accuracy (F-measure = 86.3%; precision = 95%; recall = 79...
September 14, 2016: Western Journal of Nursing Research
https://www.readbyqxmd.com/read/27536970/gender-representation-on-journal-editorial-boards-in-the-mathematical-sciences
#7
Chad M Topaz, Shilad Sen
We study gender representation on the editorial boards of 435 journals in the mathematical sciences. Women are known to comprise approximately 15% of tenure-stream faculty positions in doctoral-granting mathematical sciences departments in the United States. Compared to this group, we find that 8.9% of the 13067 editorships in our study are held by women. We describe group variations within the editorships by identifying specific journals, subfields, publishers, and countries that significantly exceed or fall short of this average...
2016: PloS One
https://www.readbyqxmd.com/read/27437047/using-electronic-case-summaries-to-elicit-multi-disciplinary-expert-knowledge-about-referrals-to-post-acute-care
#8
Kathryn H Bowles, Sarah Ratcliffe, Sheryl Potashnik, Maxim Topaz, John Holmes, Nai-Wei Shih, Mary D Naylor
BACKGROUND: Eliciting knowledge from geographically dispersed experts given their time and scheduling constraints, while maintaining anonymity among them, presents multiple challenges. OBJECTIVES: Describe an innovative, Internet based method to acquire knowledge from experts regarding patients who need post-acute referrals. Compare, 1) the percentage of patients referred by experts to percentage of patients actually referred by hospital clinicians, 2) experts' referral decisions by disciplines and geographic regions, and 3) most common factors deemed important by discipline...
2016: Applied Clinical Informatics
https://www.readbyqxmd.com/read/27355527/urinary-tissue-inhibitor-of-metalloproteinase-2-and-insulin-like-growth-factor-binding-protein-7-for-risk-stratification-of-acute-kidney-injury-in-patients-with-sepsis
#9
Patrick M Honore, H Bryant Nguyen, Michelle Gong, Lakhmir S Chawla, Sean M Bagshaw, Antonio Artigas, Jing Shi, Olivier Joannes-Boyau, Jean-Louis Vincent, John A Kellum
OBJECTIVES: To examine the performance of the urinary biomarker panel tissue inhibitor of metalloproteinase-2 and insulin-like growth factor-binding protein 7 in patients with sepsis at ICU admission. To investigate the effect of nonrenal organ dysfunction on tissue inhibitor of metalloproteinase-2 and insulin-like growth factor-binding protein 7 in this population. METHOD: In this ancillary analysis, we included patients with sepsis who were enrolled in either of two trials including 39 ICUs across Europe and North America...
October 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27342582/common-chronic-conditions-do-not-affect-performance-of-cell-cycle-arrest-biomarkers-for-risk-stratification-of-acute-kidney-injury
#10
Michael Heung, Luis M Ortega, Lakhmir S Chawla, Richard G Wunderink, Wesley H Self, Jay L Koyner, Jing Shi, John A Kellum
BACKGROUND: Identification of acute kidney injury (AKI) can be challenging in patients with underlying chronic disease, and biomarkers often perform poorly in this population. In this study we examined the performance characteristics of the novel biomarker panel of urinary tissue inhibitor of metalloproteinases-2 (TIMP2) and insulin-like growth factor-binding protein 7 ([IGFBP7]) in patients with a variety of comorbid conditions. METHODS: We analyzed data from two multicenter studies of critically ill patients in which [TIMP2]•[IGFBP7] was validated for prediction of Kidney Disease: Improving Global Outcomes (KDIGO) Stage 2 or 3 AKI within 12 h...
October 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/27332419/current-trends-in-nursing-informatics-results-of-an-international-survey
#11
Laura-Maria Peltonen, Dari Alhuwail, Samira Ali, Martha K Badger, Gabrielle Jacklin Eler, Mattias Georgsson, Tasneem Islam, Eunjoo Jeon, Hyunggu Jung, Chiu-Hsiang Kuo, Adrienne Lewis, Lisiane Pruinelli, Charlene Ronquillo, Raymond Francis Sarmiento, Janine Sommer, Jude L Tayaben, Maxim Topaz
Nursing informatics (NI) can help provide effective and safe healthcare. This study aimed to describe current research trends in NI. In the summer 2015, the IMIA-NI Students Working Group created and distributed an online international survey of the current NI trends. A total of 402 responses were submitted from 44 countries. We identified a top five NI research areas: standardized terminologies, mobile health, clinical decision support, patient safety and big data research. NI research funding was considered to be difficult to acquire by the respondents...
2016: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/27332377/mining-clinicians-electronic-documentation-to-identify-heart-failure-patients-with-ineffective-self-management-a-pilot-text-mining-study
#12
Maxim Topaz, Kavita Radhakrishnan, Victor Lei, Li Zhou
Effective self-management can decrease up to 50% of heart failure hospitalizations. Unfortunately, self-management by patients with heart failure remains poor. This pilot study aimed to explore the use of text-mining to identify heart failure patients with ineffective self-management. We first built a comprehensive self-management vocabulary based on the literature and clinical notes review. We then randomly selected 545 heart failure patients treated within Partners Healthcare hospitals (Boston, MA, USA) and conducted a regular expression search with the compiled vocabulary within 43,107 interdisciplinary clinical notes of these patients...
2016: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/27332195/nursing-informatics-research-priorities-for-the-future-recommendations-from-an-international-survey
#13
Laura-Maria Peltonen, Maxim Topaz, Charlene Ronquillo, Lisiane Pruinelli, Raymond Francis Sarmiento, Martha K Badger, Samira Ali, Adrienne Lewis, Mattias Georgsson, Eunjoo Jeon, Jude L Tayaben, Chiu-Hsiang Kuo, Tasneem Islam, Janine Sommer, Hyunggu Jung, Gabrielle Jacklin Eler, Dari Alhuwail
We present one part of the results of an international survey exploring current and future nursing informatics (NI) research trends. The study was conducted by the International Medical Informatics Association Nursing Informatics Special Interest Group (IMIA-NISIG) Student Working Group. Based on findings from this cross-sectional study, we identified future NI research priorities. We used snowball sampling technique to reach respondents from academia and practice. Data were collected between August and September 2015...
2016: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/27332175/advancing-nursing-informatics-in-the-next-decade-recommendations-from-an-international-survey
#14
Maxim Topaz, Charlene Ronquillo, Laura-Maria Peltonen, Lisiane Pruinelli, Raymond Francis Sarmiento, Martha K Badger, Samira Ali, Adrienne Lewis, Mattias Georgsson, Eunjoo Jeon, Jude L Tayaben, Chiu-Hsiang Kuo, Tasneem Islam, Janine Sommer, Hyunggu Jung, Gabrielle Jacklin Eler, Dari Alhuwail
In the summer of 2015, the International Medical Informatics Association Nursing Informatics Special Interest Group (IMIA NISIG) Student Working Group developed and distributed an international survey of current and future trends in nursing informatics. The survey was developed based on current literature on nursing informatics trends and translated into six languages. Respondents were from 31 different countries in Asia, Africa, North and Central America, South America, Europe, and Australia. This paper presents the results of responses to the survey question: "What should be done (at a country or organizational level) to advance nursing informatics in the next 5-10 years?" (n responders = 272)...
2016: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/27183846/cardiovascular-risk-in-patients-with-alopecia-areata-aa-a-propensity-matched-retrospective-analysis
#15
Kathie P Huang, Cara J Joyce, Maxim Topaz, Ye Guo, Arash Mostaghimi
BACKGROUND: The cardiovascular risk of patients with alopecia areata (AA) is not well characterized, with limited studies evaluating the risk of acute myocardial infarction (AMI) and ischemic stroke. OBJECTIVE: We sought to determine the risk for patients with AA to develop subsequent stroke and AMI. METHODS: We conducted propensity-matched retrospective analysis between January 1, 2000, and January 1, 2010, from Brigham and Women's Hospital and Massachusetts General Hospital in Boston, MA...
July 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27162283/percutaneous-ultrasound-guided-topaz-radiofrequency-coblation-a-novel-coaxial-technique-for-the-treatment-of-recalcitrant-plantar-fasciitis-our-experience
#16
Amit Shah, Alistair J Best, Winston J Rennie
Various therapeutic options are available for treatment of recalcitrant plantar fasciitis. Studies using TOPAZ coblation (ArthroCare, Sunnyvale, CA) have had good early results. The current coblation technique involves a surgical incision or breach of the highly specialized plantar fat pad, which can be associated with risks. We describe a novel technique of ultrasound-guided percutaneous coblation with a lateral heel approach. Advantages include precise targeting of the plantar fascia by direct dynamic visualization of the coblation tip, a true percutaneous approach with a needle skin puncture (<5 mm), and preservation of the plantar fat pad by using a lateral heel approach...
June 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/27131070/drug-induced-brugada-syndrome-clinical-characteristics-and-risk-factors
#17
Maayan Konigstein, Raphael Rosso, Guy Topaz, Pieter G Postema, Limor Friedensohn, Karin Heller, David Zeltser, Bernard Belhassen, Arnon Adler, Sami Viskin
BACKGROUND: Cardiac arrest may result from seemingly innocuous medications that do not necessarily have cardiac indications. The best-known example is the drug-induced long QT syndrome. A less known but not necessarily less important form of drug-induced proarrhythmia is the drug-induced Brugada syndrome. OBJECTIVE: The purpose of this study was to identify clinical and ECG risk markers for drug-induced Brugada syndrome. METHODS: Reports of drug-induced Brugada syndrome recounted by an international database (http://www...
May 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27047306/expanding-lorentz-and-spectrum-corrections-to-large-volumes-of-reciprocal-space-for-single-crystal-time-of-flight-neutron-diffraction
#18
Tara M Michels-Clark, Andrei T Savici, Vickie E Lynch, Xiaoping Wang, Christina M Hoffmann
Evidence is mounting that potentially exploitable properties of technologically and chemically interesting crystalline materials are often attributable to local structure effects, which can be observed as modulated diffuse scattering (mDS) next to Bragg diffraction (BD). BD forms a regular sparse grid of intense discrete points in reciprocal space. Traditionally, the intensity of each Bragg peak is extracted by integration of each individual reflection first, followed by application of the required corrections...
April 1, 2016: Journal of Applied Crystallography
https://www.readbyqxmd.com/read/26970431/drug-allergies-documented-in-electronic-health-records-of-a-large-healthcare-system
#19
L Zhou, N Dhopeshwarkar, K G Blumenthal, F Goss, M Topaz, S P Slight, D W Bates
BACKGROUND: The prevalence of drug allergies documented in electronic health records (EHRs) of large patient populations is understudied. OBJECTIVE: We aimed to describe the prevalence of common drug allergies and patient characteristics documented in EHRs of a large healthcare network over the last two decades. METHODS: Drug allergy data were obtained from EHRs of patients who visited two large tertiary care hospitals in Boston from 1990 to 2013...
September 2016: Allergy
https://www.readbyqxmd.com/read/26948593/isotopic-and-elemental-characterisation-of-slovenian-apple-juice-according-to-geographical-origin-preliminary-results
#20
Karmen Bizjak Bat, Klemen Eler, Darja Mazej, Branka Mozetič Vodopivec, Ines Mulič, Peter Kump, Nives Ogrinc
This study examined the applicability of stable isotope and multi-element data for determining the geographical origin of fresh apple juices. Samples included three apple cultivars (Idared, Golden Delicious and Topaz) harvested in 2011 and 2012 from five different geographical regions of Slovenia. Regional discrimination of the juice samples was most successful when using linear discriminant analysis (LDA) and taking into account the following parameters: δ(2)H and δ(18)O content of juice water; δ(15)N and δ(13)C content of the pulp, (D/H)I and (D/H)II in ethanol and the concentration of S, Cl, Fe, Cu, Zn and Sr...
July 15, 2016: Food Chemistry
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