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Megan Nichols, Nadav Topaz, Xiong Wang, Xin Wang, Dave Boxrud
Neisseria is a diverse genus that includes commensal and pathogenic species that pose a public health threat. While the pathogenic species have been studied extensively, many of the commensals have limited genomic information available. Here, we present draft genome sequences for a diverse set of 37 isolates from 10 Neisseria species.
May 17, 2018: Genome Announcements
Cheng Zhou, Dongfang Wang, Francesca Condemi, Guangfeng Zhao, Stephen Topaz, Cherry Ballard-Croft, Joseph B Zwischenberger
The AvalonElite double lumen cannula (DLC) provides total cavopulmonary assist (CPA) in failing Fontan sheep, but recirculation limits reliability. To improve CPA performance, a two-valve extracardiac conduit (ECC) was used to bracket infusion blood toward pulmonary artery (PA). A total cavopulmonary connection with failing Fontan circulation adult sheep model was created with valved ECC (n = 6). The valved ECC was connected to superior/inferior venae cavae (SVC/IVC) and right PA. The AvalonElite DLC was inserted from right jugular vein with infusion opening between the ECC valves...
May 8, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Eitan Erez Zahavi, Noam Steinberg, Topaz Altman, Michael Chein, Yuvraj Joshi, Tal Gradus-Pery, Eran Perlson
Tropomyosin-related tyrosine kinase B (TrkB) is the receptor for brain-derived neurotrophic factor (BDNF) and provides critical signaling that supports the development and function of the mammalian nervous system. Like other receptor tyrosine kinases (RTKs), TrkB is thought to signal as a dimer. Using cell imaging and biochemical assays, we found that TrkB acted as a monomeric receptor at the plasma membrane regardless of its binding to BDNF and initial activation. Dimerization occurred only after the internalization and accumulation of TrkB monomers within BDNF-containing endosomes...
May 8, 2018: Science Signaling
Guy Topaz, Ory Haisraely, Yacov Shacham, Gil Beery, Lotan Shilo, Nuha Kassem, David Pereg, Yona Kitay-Cohen
BACKGROUND: Chest-pain patients deemed safe for discharge from internal medicine wards might still be at risk for adverse outcomes. HYPOTHESIS: CHA2 DS2 -VASc score improves risk stratification of low-risk chest-pain patients discharged after acute coronary syndrome (ACS) rule-out. METHODS: We accessed medical records of patients who were admitted to internal medicine wards at a single medical center during 2010-2016 and discharged following an ACS rule-out...
April 23, 2018: Clinical Cardiology
Guy Topaz, Adi Karas, Nuha Kassem, Yona Kitay-Cohen, David Pereg, Lotan Shilo, Adi Zoref-Lorenz, Alon Y Hershko
BACKGROUND: Iodinated contrast media (ICM) allergy may entail severe adverse events in patients who undergo percutaneous coronary intervention (PCI). Premedication protocols and low-osmolality contrast media have been thought to improve the outcomes of these individuals. OBJECTIVE: To assess the prevalence and severity of allergic reactions during PCI in patients admitted for investigation of chest pain. METHODS: This is a retrospective analysis of 13,652 patients who were hospitalized with chest pain during the years 2010-2016, at the Department of Internal Medicine, Meir Medical Center...
April 12, 2018: Journal of Allergy and Clinical Immunology in Practice
Inbal Maidan, Shiran Shustak, Topaz Sharon, Hagar Bernad-Elazari, Nimrod Geffen, Nir Giladi, Jeffrey M Hausdorff, Anat Mirelman
BACKGROUND: Obstacle negotiation is a daily activity that requires the integration of sensorimotor and cognitive information. Recent studies provide evidence for the important role of prefrontal cortex during obstacle negotiation. We aimed to explore the effects of obstacle height and available response time on prefrontal activation. METHODS: Twenty healthy young adults (age: 30.1 ± 1.0 years; 50% women) walked in an obstacle course while negotiating anticipated and unanticipated obstacles at heights of 50 mm and 100 mm...
April 2018: Brain and Cognition
Guy Topaz, Wesal Gharra, Alon Eisen, Alon Y Hershko, Lotan Shilo, Gil Beeri, Yona Kitay-Cohen, David Pereg
BACKGROUND: Assessment of chest pain is one of the most common reasons for hospital admissions in internal medicine wards. However, little is known regarding predictors for poor prognosis in patients discharged from internal medicine wards after acute coronary syndrome (ACS) rule-out. OBJECTIVE: To assess the association of kidney function with mortality and hospital admissions due to ACS in patients with chest pain who were discharged from internal medicine wards following ACS rule-out...
February 5, 2018: European Journal of Internal Medicine
Sumudu Tennakoon, Ye Peng, Mainak Mookherjee, Sergio Speziale, Geeth Manthilake, Tiglet Besara, Luis Andreu, Fernando Rivera
Topaz is an aluminosilicate mineral phase stable in the hydrothermally altered pegmatitic rocks and also in subducted sedimentary lithologies. In nature, topaz often exhibits solid solution between fluorine and hydrous end members. We investigated elasticity of naturally occurring single crystal topaz (Al2 SiO4 F1.42 (OH)0.58 ) using Resonant Ultrasound Spectroscopy. We also explored the temperature dependence of the full elastic constant tensor. We find that among the various minerals stable in the Al2 O3 -SiO2 -H2 O ternary system, topaz exhibits moderate elastic anisotropy...
January 22, 2018: Scientific Reports
Tom Topaz, Roey Egozi, Gil Eshel, Benny Chefetz
Cultivated land is a major source of pesticides, which are transported with the runoff water and eroded soil during rainfall events and pollute riverine and estuarine environments. Common ecotoxicological assessments of riverine systems are mainly based on water sampling and analysis of only the dissolved phase, and address a single pesticide's toxicological impact under laboratory conditions. A clear overview of mixtures of pesticides in the adsorbed and dissolved phases is missing, and therefore the full ecotoxicological impact is not fully addressed...
June 1, 2018: Science of the Total Environment
On Topaz
The benefits of nitroglycerin are numerous, from ensuring accurate interpretation of diagnostic angiograms to treatment of coronary spasm and support of PCIs in simple or complex lesion types. The founders of the field were convinced that no coronary arteriography should be considered complete unless a vasodilator is used at some point during the study. This recommendation is valid. The guidelines should change to include administration of intracoronary nitroglycerin.
December 1, 2017: Catheterization and Cardiovascular Interventions
Golan Shahar, Sheera F Lerman, Maayan Topaz, Silviu Brill, Hadar Shalev, Zvia Rudich
OBJECTIVE: Chronic physical pain is one of modern medicine's principal challenges. Recently, there has been a keen research interest in the role of depressive personality vulnerability (DPV) in the course of chronic pain. This is the first attempt to examine the role of three leading DPV dimensions-sociotropy, autonomy, and self-criticism-in chronic pain. METHOD: Chronic pain patients (N = 428) were assessed four times as to their pain, disability, anxious depression, and pain-based catastrophizing...
December 9, 2017: Journal of Personality
Nadav Topaz, Nazia Mojib, Aroon T Chande, Julia Kubanek, I King Jordan
January 1, 2017: Database: the Journal of Biological Databases and Curation
Bo-Ye Fu, Li-Yun Fu
Stress-induced velocity variations for porous rocks are generally characterized by a strong nonlinear dependence on stress associated with complex deformations under loading. The classical theory of poro-acoustoelasticity with high-order elastic constants is based on the Taylor expansion of the strain energy function, encountering problems of divergence and limitless elastic wave velocities in describing stress-associated velocity variations, especially for high effective stresses. The extension of the theory beyond the high-order elastic constants based on the Padé approximation to the strain energy function is addressed in this article...
November 2017: Journal of the Acoustical Society of America
Rona Katzengold, Moris Topaz, Amit Gefen
Regulated negative pressure-assisted wound therapy (RNPT) is one of the most important wound treatment technologies developed and applied over the last two decades. To-date RNPT has been proven to be clinically effective in treating chronic wounds, however, the effects of different specific pressure delivery protocols on the progress and quality of tissue repair are not adequately understood yet. Here, we suggest a viscoelastic, three-dimensional finite element modeling framework of RNPT, with several realistic features such as a non-symmetrically configured multi-layered tissue structure...
October 28, 2017: Journal of Tissue Viability
Yoshihiro Imai, Takehiro Yamashita, On Topaz
RATIONALE: Thin-cap fibroatheroma (TCFA) and red thrombus are suggested as a high-risk of embolic complications during percutaneous coronary intervention (PCI). Intracoronary aspiration procedures occasionally result in either an insufficient thrombus removal or provide no significant effects on TCFA. PATIENT CONCERNS: A 76-year-old male underwent coronary angiography for chest pain. DIAGNOSES: Coronary angiography revealed a tight stenosis at the right coronary artery which resulted in treatment by PCI...
October 2017: Medicine (Baltimore)
Maxim Topaz, Katherine Gaddes, Margret McDonald, Kathryn Bowles
No abstract text is available yet for this article.
2017: Studies in Health Technology and Informatics
Maxim Topaz, Adam Schaffer, Warren Acker, Ken Lai, Tom Korah Zfania, Jonathan Einbinder, Li Zhou
No abstract text is available yet for this article.
2017: Studies in Health Technology and Informatics
Ivana Yeow, Gillian Howard, Jessica Chadwick, Carolina Mendoza-Topaz, Carsten G Hansen, Benjamin J Nichols, Elena Shvets
Caveolae introduce flask-shaped convolutions into the plasma membrane and help to protect the plasma membrane from damage under stretch forces. The protein components that form the bulb of caveolae are increasingly well characterized, but less is known about the contribution of proteins that localize to the constricted neck. Here we make extensive use of multiple CRISPR/Cas9-generated gene knockout and knockin cell lines to investigate the role of Eps15 Homology Domain (EHD) proteins at the neck of caveolae...
October 9, 2017: Current Biology: CB
Sebastian Weingärtner, Chetan Shenoy, Benedikt Rieger, Lothar R Schad, Jeanette Schulz-Menger, Mehmet Akçakaya
PURPOSE: To develop and evaluate a cardiac phase-resolved myocardial T1 mapping sequence. METHODS: The proposed method for temporally resolved parametric assessment of Z-magnetization recovery (TOPAZ) is based on contiguous fast low-angle shot imaging readout after magnetization inversion from the pulsed steady state. Thereby, segmented k-space data are acquired over multiple heartbeats, before reaching steady state. This results in sampling of the inversion-recovery curve for each heart phase at multiple points separated by an R-R interval...
April 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
L A McNamara, N Topaz, X Wang, S Hariri, L Fox, J R MacNeil
No abstract text is available yet for this article.
September 2017: American Journal of Transplantation
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