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https://www.readbyqxmd.com/read/28780304/response-to-the-letter-to-the-editor
#1
Guy Topaz, Yona Kitay-Cohen, Lotan Shilo
No abstract text is available yet for this article.
July 29, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28707447/cto-revascularization-obstacles-and-options-in-balloon-nonpenetrable-lesions
#2
EDITORIAL
On Topaz
CTO lesions resisting balloon crossing are located in moderate/severe tortuous coronary arteries contain more moderate/severe calcification burden and carry a higher J-CTO score as compared with balloon crossable CTO lesions. CTO lesions resisting balloon crossing do not constitute a homogenous group. In 25% of the patients, the resisting CTO was caused by stent restenosis and thrombus is an integral component of CTO in addition to calcium and fibrosis. The excimer laser and rotational/orbital atherectomy are among useful debulking technologies capable of creating a "pilot recanalization channel" in the CTO that enables completion of the revasularization...
July 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28704351/high-risk-for-invasive-meningococcal-disease-among-patients-receiving-eculizumab-soliris-despite-receipt-of-meningococcal-vaccine
#3
Lucy A McNamara, Nadav Topaz, Xin Wang, Susan Hariri, LeAnne Fox, Jessica R MacNeil
Use of eculizumab (Soliris, Alexion Pharmaceuticals), a terminal complement inhibitor, is associated with a 1,000-fold to 2,000-fold increased incidence of meningococcal disease (1). Administration of meningococcal vaccines is recommended for patients receiving eculizumab before beginning treatment (2,3). Sixteen cases of meningococcal disease were identified in eculizumab recipients in the United States during 2008-2016; among these, 11 were caused by nongroupable Neisseria meningitidis. Fourteen patients had documentation of receipt of at least 1 dose of meningococcal vaccine before disease onset...
July 14, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28645805/pre-admission-cha2ds2-vasc-score-and-outcome-of-patients-with-acute-cerebrovascular-events
#4
Guy Topaz, David Pereg, Mony Shuvy, Stefan Mausbach, Itzhak Kimiagar, Gregory Telman, Yona Kitay-Cohen, Dina Vorobeichik, Nir Shlomo, David Tanne
BACKGROUND: The CHA2DS2-VASc score has been recommended for the assessment of thromboembolic risk in patients with atrial fibrillation. Data regarding the association between the pre-admission CHA2DS2-VASc score and the outcome of patients with stroke and TIA are scarce. We aimed to assess the predictive value of pre-admission CHA2DS2-VASc score for early risk stratification of patients with acute cerebrovascular event. METHODS: The study group consisted of 8309 patients (53% males, mean age of 70±13...
June 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28577971/prevalence-of-food-allergies-and-intolerances-documented-in-electronic-health-records
#5
Warren W Acker, Joseph M Plasek, Kimberly G Blumenthal, Kenneth H Lai, Maxim Topaz, Diane L Seger, Foster R Goss, Sarah P Slight, David W Bates, Li Zhou
BACKGROUND: Food allergy prevalence is reported to be increasing, but epidemiological data using patients' electronic health records (EHRs) remain sparse. OBJECTIVE: We sought to determine the prevalence of food allergy and intolerance documented in the EHR allergy module. METHODS: Using allergy data from a large health care organization's EHR between 2000 and 2013, we determined the prevalence of food allergy and intolerance by sex, racial/ethnic group, and allergen group...
May 23, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28554095/the-association-between-red-cell-distribution-width-and-poor-outcomes-in-hospitalized-patients-with-influenza
#6
Guy Topaz, Yona Kitay-Cohen, Lee Peled, Wesal Gharra, Keren Kaminer, Mayan Eitan, Lamis Mahamid, Lotan Shilo
PURPOSE: To examine an association between red blood cell distribution width (RDW) and the prognosis of influenza patients. METHODS: We conducted a retrospective analysis of patients hospitalized with influenza during 2012-2015 in the internal medicine wards of one medical center. RDW measurements during hospitalization were analyzed. Primary outcome was complicated hospitalization (defined as at least one of: length of stay ≥7days, need for mechanical ventilation, septic shock, transfer to intensive-care, or 30-day mortality)...
May 23, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28495412/radiofrequency-microdebridement-versus-surgical-decompression-for-achilles-tendinosis-a-randomized-controlled-trial
#7
Rory J M Morrison, Timothy M Brock, Mike R Reed, Scott D Muller
Achilles tendinosis is primarily managed nonoperatively with activity modification and physiotherapy, although surgery can be required. This has classically involved surgical decompression of the Achilles tendon, although the use of radiofrequency microdebridement has been suggested as a novel minimally invasive alternative. We present a randomized controlled trial comparing radiofrequency microdebridement using the Topaz(®) microdebrider wand and traditional surgical decompression. All patients with Achilles tendinosis referred to a single surgeon and meeting the inclusion criteria were invited to participate in our single-blinded, randomized controlled study...
July 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28479081/identifying-distinct-risk-profiles-to-predict-adverse-events-among-community-dwelling-older-adults
#8
Melissa O'Connor, Alexandra Hanlon, Elizabeth Mauer, Salimah Meghani, Ruth Masterson-Creber, Sherry Marcantonio, Ken Coburn, Janet Van Cleave, Joan Davitt, Barbara Riegel, Kathryn H Bowles, Susan Keim, Sherry A Greenberg, Justine S Sefcik, Maxim Topaz, Dexia Kong, Mary Naylor
Preventing adverse events among chronically ill older adults living in the community is a national health priority. The purpose of this study was to generate distinct risk profiles and compare these profiles in time to: hospitalization, emergency department (ED) visit or death in 371 community-dwelling older adults enrolled in a Medicare demonstration project. Guided by the Behavioral Model of Health Service Use, a secondary analysis was conducted using Latent Class Analysis to generate the risk profiles with Kaplan Meier methodology and log rank statistics to compare risk profiles...
May 4, 2017: Geriatric Nursing
https://www.readbyqxmd.com/read/28460740/comparison-of-30-day-and-long-term-outcomes-and-hospital-complications-among-patients-aged-75-versus-%C3%A2-75%C3%A2-years-with-st-elevation-myocardial-infarction-undergoing-percutaneous-coronary-intervention
#9
COMPARATIVE STUDY
Guy Topaz, Ariel Finkelstein, Nir Flint, Yacov Shacham, Shmuel Banai, Arie Steinvil, Yaron Arbel, Gad Keren, Lior Yankelson
Our aim was to evaluate the mortality rate and occurrence of complications in patients aged <75 versus ≥75 years with ST-elevation myocardial infarction (STEMI). We studied 1,657 consecutive patients with STEMI hospitalized in the cardiac intensive care unit during 2008 to 2014. All patients underwent primary percutaneous intervention, of which 292 (18%) were aged ≥75 years. Patient records were evaluated for in-hospital complications, 30-day mortality, and long-term mortality over a mean period of 3...
June 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28390742/long-term-prognosis-of-atrial-fibrillation-in-st-elevation-myocardial-infarction-patients-undergoing-percutaneous-coronary-intervention
#10
Guy Topaz, Nir Flint, Arie Steinvil, Arik Finkelstein, Shmuel Banai, Gad Keren, Yacov Shacham, Lior Yankelson
BACKGROUND: Atrial fibrillation (AF) is a well-known complication in the setting of ST elevation myocardial infarction (STEMI). Data on the long-term prognostic implications of New-Onset AF (NOAF) complicating STEMI in the era of complete revascularization remains controversial. Our aim therefore was to evaluate the long-term prognosis of prior AF (pAF) and new-onset AF (NOAF) in STEMI patients undergoing percutaneous coronary intervention (PCI). METHODS: We studied 1657 consecutive STEMI patients hospitalized in the cardiac intensive care unit during 2008-2014...
March 16, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28373710/single-cell-imaging-and-quantification-of-tdp-43-and-%C3%AE-synuclein-intercellular-propagation
#11
Sivan Peled, Dorin Sade, Yaron Bram, Ziv Porat, Topaz Kreiser, Michael Mimouni, Alexandra Lichtenstein, Daniel Segal, Ehud Gazit
The intercellular spreading of protein assemblies is a major factor in the progression of neurodegenerative disorders. The quantitative study and visualization of cell-to-cell propagation using tagged-proteins is challenging due to the steric effect of relatively large fluorescence tags and the risk of 'false positive' identification when analyzing these rare transmission events. Here, we established a cell culture model to characterize the cell-to-cell transmission of TAR DNA-binding protein and α-synuclein, involved in amyotrophic lateral sclerosis and Parkinson's disease, respectively, using the small nine amino acid influenza hemagglutinin tag...
March 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28300211/als-along-the-axons-expression-of-coding-and-noncoding-rna-differs-in-axons-of-als-models
#12
Nimrod Rotem, Iddo Magen, Ariel Ionescu, Noga Gershoni-Emek, Topaz Altman, Christopher J Costa, Tal Gradus, Metsada Pasmanik-Chor, Dianna E Willis, Iddo Z Ben-Dov, Eran Hornstein, Eran Perlson
Amyotrophic lateral sclerosis (ALS) is a multifactorial lethal motor neuron disease with no known treatment. Although the basic mechanism of its degenerative pathogenesis remains poorly understood, a subcellular spatial alteration in RNA metabolism is thought to play a key role. The nature of these RNAs remains elusive, and a comprehensive characterization of the axonal RNAs involved in maintaining neuronal health has yet to be described. Here, using cultured spinal cord (SC) neurons grown using a compartmented platform followed by next-generation sequencing (NGS) technology, we find that RNA expression differs between the somatic and axonal compartments of the neuron, for both mRNA and microRNA (miRNA)...
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28295260/hospital-readmission-and-social-risk-factors-identified-from-physician-notes
#13
Amol S Navathe, Feiran Zhong, Victor J Lei, Frank Y Chang, Margarita Sordo, Maxim Topaz, Shamkant B Navathe, Roberto A Rocha, Li Zhou
OBJECTIVE: To evaluate the prevalence of seven social factors using physician notes as compared to claims and structured electronic health records (EHRs) data and the resulting association with 30-day readmissions. STUDY SETTING: A multihospital academic health system in southeastern Massachusetts. STUDY DESIGN: An observational study of 49,319 patients with cardiovascular disease admitted from January 1, 2011, to December 31, 2013, using multivariable logistic regression to adjust for patient characteristics...
March 13, 2017: Health Services Research
https://www.readbyqxmd.com/read/28273615/dispersion-analysis-of-arbitrarily-cut-orthorhombic-crystals
#14
Sonja Höfer, Vladimir Ivanovski, Reinhard Uecker, Albert Kwasniewski, Jürgen Popp, Thomas G Mayerhöfer
We developed a measurement and evaluation scheme to perform dispersion analysis on arbitrarily cut orthorhombic crystals based on the schemes developed for triclinic and uniaxial crystals. As byproduct of dispersion analysis the orientations of the crystal axes are found. In contrast to the spectra of arbitrarily cut uniaxial crystals, where the fit routine has to separate two independent principal spectra, the spectra of arbitrarily cut orthorhombic crystals are a combination of three independent spectra and the evaluation scheme gets more complex...
March 3, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28205765/date-september-19-2016-08-00-10-00-fa01-featured-abstracts-1-minimally-invasive-esophagectomy-malignant-room-topaz-concourse
#15
Jennifer Straatman, Miguel Cuesta, Josep Roig Garcia, Luigi Bonavina, C Rosman, Suzanne Gisbertz, D L Van Der Peet
No abstract text is available yet for this article.
September 1, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28106594/big-data-and-nursing-implications-for-the-future
#16
Maxim Topaz, Lisiane Pruinelli
Big data is becoming increasingly more prevalent and it affects the way nurses learn, practice, conduct research and develop policy. The discipline of nursing needs to maximize the benefits of big data to advance the vision of promoting human health and wellbeing. However, current practicing nurses, educators and nurse scientists often lack the required skills and competencies necessary for meaningful use of big data. Some of the key skills for further development include the ability to mine narrative and structured data for new care or outcome patterns, effective data visualization techniques, and further integration of nursing sensitive data into artificial intelligence systems for better clinical decision support...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28106590/competency-recommendations-for-advancing-nursing-informatics-in-the-next-decade-international-survey-results
#17
Charlene Ronquillo, Maxim Topaz, Lisiane Pruinelli, Laura-Maria Peltonen, Raji Nibber
The IMIA-NIstudents' and emerging professionals' working group conducted a large international survey in 2015 regarding research trends in nursing informatics. The survey was translated into half-a-dozen languages and distributed through 18 international research collaborators' professional connections. The survey focused on the perspectives of nurse informaticians. A total of 272 participants responded to an open ended question concerning recommendations to advance nursing informatics. Five key areas for action were identified through our thematic content analysis: education, research, practice, visibility and collaboration...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/27802063/in-silico-analysis-of-candidate-proteins-sharing-homology-with-streptococcus-agalactiae-proteins-and-their-role-in-male-infertility
#18
Rajeshwari Parida, Luna Samanta
Leukocytospermia is a physiologic condition defined as human semen with a leukocyte count of >1 x 10(6) cells/ml that is often correlated with male infertility. Moreover, bacteriospermia has been associated with leukocytospermia ultimately leading to male infertility. We have found that semen samples with >1 x 10(6)/ml leukocytes and/or bacteriospermia have oxidative predominance as evidenced by augmented protein carbonyl and lipid peroxidation status of the semen which is implicated in sperm dysfunction...
November 1, 2016: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/27729200/towards-improved-drug-allergy-alerts-multidisciplinary-expert-recommendations
#19
EDITORIAL
Maxim Topaz, Foster Goss, Kimberly Blumenthal, Kenneth Lai, Diane L Seger, Sarah P Slight, Paige G Wickner, George A Robinson, Kin Wah Fung, Robert C McClure, Shelly Spiro, Warren W Acker, David W Bates, Li Zhou
No abstract text is available yet for this article.
January 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/27701750/assessment-of-respiratory-distress-by-the-roth-score
#20
Ehud Chorin, Allison Padegimas, Ofer Havakuk, Edo Y Birati, Yacov Shacham, Anat Milman, Guy Topaz, Nir Flint, Gad Keren, Ori Rogowski
INTRODUCTION: Health care demand is increasing due to greater longevity of patients with chronic comorbidities. This increasing demand is occurring in a setting of resource scarcity. To address these changes, high-value care initiatives, such as telemedicine, are valuable resource-preservation strategies. This study introduces the Roth score as a telemedicine tool that uses patient counting times to accurately risk-stratify dyspnea severity in terms of hypoxia. HYPOTHESIS: The Roth score has correlation with dyspnea severity...
November 2016: Clinical Cardiology
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