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https://www.readbyqxmd.com/read/29627619/impact-of-prednisone-in-patients-with-repeated-embryo-implantation-failures-beneficial-or-deleterious
#1
REVIEW
Nathalie Lédée, Laura Prat-Ellenberg, Marie Petitbarat, Lucie Chevrier, Cynthia Simon, Elie El Irani, Dominique Vitoux, Armand Bensussan, Gérard Chaouat
INTRODUCTION: Corticotherapy is the leading medication worldwide for patients with history of repeated implantation failures (RIF) after IVF/ICSI. Nevertheless, we still do not know its local mechanism of action, hence its precise indication. Our objective is to document the impact of prednisone on the endometrial expression of immune biomarkers (CD56 cells count, IL-18/TWEAK, IL-15/Fn-14 mRNA ratio) at the time of uterine receptivity in a RIF population. MATERIALS AND METHOD: An endometrial biopsy was realized in the mid luteal phase for immune profiling: IL-15/Fn-14 and IL-18/TWEAK mRNA ratios were determined by quantitative RT-PCR and CD56 mobilization per IHC...
March 26, 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29619283/humanitarian-needs-in-government-controlled-areas-of-syria
#2
Shannon Doocy, Emily Lyles
Background: Five years of conflict in Syria have led to 13.5 million people in need of humanitarian assistance and 6.6 million internally displaced people. Humanitarian needs are ever-increasing as an inability to maintain humanitarian corridors and ceasefires continue. In light of the protracted nature of the conflict, immense needs, and dearth of large-scale data, we undertook this assessment to inform humanitarian response. Methods: A survey of accessible areas, which were largely urban and government controlled, was undertaken from April - June 2016 to identify unmet needs and assistance priorities...
February 15, 2018: PLoS Currents
https://www.readbyqxmd.com/read/29617817/decreased-pecam1-mediated-tgf-%C3%AE-1-expression-in-the-mid-secretory-endometrium-in-women-with-recurrent-implantation-failure
#3
Feng Guo, Chenchen Si, Mingjuan Zhou, Jingwen Wang, Dan Zhang, Peter C K Leung, Bufang Xu, Aijun Zhang
STUDY QUESTION: Is recurrent implantation failure (RIF) associated with decreased expression of platelet and endothelial cell adhesion molecule 1 (PECAM1) and transforming growth factor β1 (TGF-β1) in the endometrium during the implantation window? SUMMARY ANSWER: The present study demonstrates that the expression of PECAM1 and TGF-β1 is significantly decreased in the mid-secretory endometrium in women with RIF, which may account for embryo implantation failure...
March 30, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29589222/development-of-novel-octanoyl-chitosan-nanoparticles-for-improved-rifampicin-pulmonary-delivery-optimization-by-factorial-design
#4
Kailash C Petkar, Sandip Chavhan, N Kunda, I Saleem, S Somavarapu, Kevin M G Taylor, Krutika K Sawant
A novel hydrophobic chitosan derivative, octanoyl chitosan (OC) with improved organic solubility was synthesized, characterized, and employed for the preparation of rifampicin (Rif) encapsulated nanoparticle formulations for pulmonary delivery. OC was characterized to confirm acyl group substitution and cytotoxicity in A549 epithelial lung cells. OC nanoparticles were produced by the double emulsion solvent evaporation technique without cross-linking and characterized for particle size distribution, morphology, crystallinity, thermal stability, aerosol delivery, and drug release rate...
March 27, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29580818/tuberculosis-advances-and-challenges-in-development-of-new-diagnostics-and-biomarkers
#5
REVIEW
Gerhard Walzl, Ruth McNerney, Nelita du Plessis, Matthew Bates, Timothy D McHugh, Novel N Chegou, Alimuddin Zumla
Tuberculosis remains the leading cause of death from an infectious disease worldwide. Early and accurate diagnosis and detection of drug-sensitive and drug-resistant tuberculosis is essential for achieving global tuberculosis control. Despite the introduction of the Xpert MTB/RIF assay as the first-line rapid tuberculosis diagnostic test, the gap between global estimates of incidence and new case notifications is 4·1 million people. More accurate, rapid, and cost-effective screening tests are needed to improve case detection...
March 23, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29516891/enhancing-antimycobacterial-activity-of-isoniazid-and-rifampicin-incorporated-norbornene-nanoparticles
#6
Kalaiselvi Kumarasingam, Mangayarkarasi Vincent, Shivshankar R Mane, Raja Shunmugam, S Sivakumar, K R Uma Devi
Background: Tuberculosis (TB) has been identified in skeletons over 6000 years old and still remains as the most prevalent infectious disease in the world; thus, there is a need for development of new drugs or tuning of old drugs. Nanotechnology, an advanced technology, plays a vital role in research for the diagnosis and treatment of TB, thus preventing adverse effects and drug resistance. The objective of this study was to enhance the antimycobacterial activity of isoniazid- (INH) and rifampicin (RIF)-incorporated norbornene (NOR) nanoparticles in comparison with plain INH and RIF without nanoparticles...
January 2018: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29504735/does-autoimmunity-play-a-role-in-the-risk-of-implantation-failures
#7
Hanna Motak-Pochrzest, Andrzej Malinowski
158 non-pregnant women with recurrent implantation failures after IVF/ET procedures were tested for peripheral blood autoimmune profile. The control group consisted of 76 patients after first successful IVF procedure and pregnancy outcome. The objective of this study was to investigate different autoantibodies peripheral blood profile after excluding anatomical, endocrinological, endometrial and genetic disorders and to estimate the risk of implantation failures. The study's including criteria were 1.indications for IVF/ET determined by male factor and unexplained infertility 2...
February 6, 2018: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29499042/multidisease-testing-for-hiv-and-tb-using-the-genexpert-platform-a-feasibility-study-in-rural-zimbabwe
#8
Zibusiso Ndlovu, Emmanuel Fajardo, Elton Mbofana, Tatenda Maparo, Daniela Garone, Carol Metcalf, Helen Bygrave, Kekeletso Kao, Sekesai Zinyowera
BACKGROUND: HIV Viral Load and Early Infant Diagnosis technologies in many high burden settings are restricted to centralized laboratory testing, leading to long result turnaround times and patient attrition. GeneXpert (Cepheid, CA, USA) is a polyvalent near point-of-care platform and is widely implemented for Xpert MTB/RIF diagnosis. This study sought to evaluate the operational feasibility of integrated HIV VL, EID and MTB/RIF testing in new GeneXpert platforms. METHODS: Whole blood samples were collected from consenting patients due for routine HIV VL testing and DBS samples from infants due for EID testing, at three rural health facilities in Zimbabwe...
2018: PloS One
https://www.readbyqxmd.com/read/29495916/voriconazole-autoinduction-and-saturable-metabolism-after-cessation-of-rifampin-in-a-patient-with-invasive-central-nervous-system-aspergillus-importance-of-therapeutic-drug-monitoring
#9
Salia Farrokh, Edina Avdic
PURPOSE: Optimization of antifungal therapy with voriconazole can be challenging due to inter- and intrapatient variability in voriconazole pharmacokinetics (PK). In this case, we introduce challenges in voriconazole therapy due to drug-drug interactions, autoinduction, and saturable metabolism. SUMMARY: A 32-year-old male on chronic prednisone developed central nervous system (CNS) aspergillosis. He was started on high-dose intravenous (IV) voriconazole 8.5 mg/kg every 12 hours due to concerns for lasting induction effects of recent rifampin therapy...
January 1, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29487256/pyrosequencing-to-resolve-discrepant-xpert-mtb-rif-and-mycobacterial-growth-indicator-tube-960
#10
Kanchan Ajbani, Mubin Kazi, Jeffrey Tornheim, Swapna Naik, Rajeev Soman, Anjali Shetty, Camilla Rodrigues
Delayed diagnosis of drug resistance has been a major obstacle to proper management and control of drug-resistant tuberculosis (TB). Expanded access to rapid molecular diagnostics such as Xpert MTB/RIF has been helpful, but has generated confusion about how to interpret genotype-phenotype discordance. Optimal management is not clearly defined for patients with rifampin resistance by Xpert MTB/RIF but rifampin susceptibility by phenotypic testing. To resolve this discrepancy, we performed pyrosequencing of discordant isolates identified at a reference laboratory over a 6-month period...
March 2018: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29486527/thoracoscopic-pleural-biopsy-improves-yield-of-xpert-mtb-rif-for-diagnosis-of-pleural-tuberculosis
#11
Devasahayam J Christopher, Sridevi Dinakaran, Richa Gupta, Prince James, Barney Isaac, Balamugesh Thangakunam
BACKGROUND AND OBJECTIVE: Extrapulmonary tuberculosis (EPTB) accounts for ~15% of all TB patients, and TB pleural effusion is the second most common site of EPTB. The diagnosis of pleural TB is challenging due to the pauci-bacillary nature of the disease. Histopathology of thoracoscopically obtained pleural biopsy provides the highest diagnostic yield. The Xpert MTB/RIF assay (Xpert) is a PCR test that can identify both Mycobacterium tuberculosis (MTB) and rifampicin resistance. Currently, there is a lack of clarity regarding the value of Xpert on pleural tissue...
February 27, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29452422/asynchronous-and-pathological-windows-of-implantation-two-causes-of-recurrent-implantation-failure
#12
P Sebastian-Leon, N Garrido, J Remohí, A Pellicer, P Diaz-Gimeno
STUDY QUESTION: Is endometrial recurrent implantation failure (RIF) only a matter of an asynchronous (displaced) window of implantation (WOI), or could it also be a pathological (disrupted) WOI? SUMMARY ANSWER: Our predictive results demonstrate that both displaced and disrupted WOIs exist and can present independently or together in the same RIF patient. WHAT IS KNOWN ALREADY: Since 2002, many gene expression signatures associated with endometrial receptivity and RIF have been described...
February 14, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29440179/role-of-c-jun-n-terminal-kinase-in-pregnane-x-receptor-mediated-induction-of-human-cytochrome-p4503a4-in-vitro
#13
Guncha Taneja, Chun Chu, Paramahamsa Maturu, Bhagavatula Moorthy, Romi Ghose
Cytochrome P450 (CYP) 3A4 is the most abundant drug metabolizing enzyme and is responsible for the metabolism of ~50% of clinically available drugs. Induction of CYP3A4 impacts the disposition of its substrates and leads to harmful clinical consequences such as failure of therapy. In order to prevent such undesirable consequences, molecular mechanisms of regulation of CYP3A4 need to be fully understood. CYP3A4 induction is primarily regulated by the xenobiotic nuclear receptor, pregnane-X-receptor (PXR). After ligand binding, PXR is transported to the nucleus, where it binds to the CYP3A4 promoter and induces its gene expression...
February 12, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29434813/association-between-vascular-endothelial-growth-factor-promoter-polymorphisms-and-the-risk-of-recurrent-implantation-failure
#14
Sung Han Shim, Jung Oh Kim, Young Joo Jeon, Hui Jeong An, Hyun Ah Lee, Ji Hyang Kim, Eun Hee Ahn, Woo Sik Lee, Nam Keun Kim
The objective of the present study was to investigate the association between recurrent implantation failure (RIF) and vascular endothelial growth factor (VEGF) gene polymorphisms that are associated with various female infertility disorders. A total of 116 women diagnosed with RIF and 218 control subjects were genotyped for the VEGF -2578C>A, -1154G>A, -634C>G and 936C>T polymorphisms using a polymerase chain reaction-restriction fragment length polymorphism assay. The VEGF -2578AA genotype was associated with an increased prevalence (≥4) of RIF [adjusted odds ratio (AOR)=2...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29422273/automated-broth-based-systems-versus-the-mycotb-plate-for-antimicrobial-susceptibility-testing-of-the-mycobacterium-tuberculosis-complex-challenges-in-interpretation
#15
Isabella W Martin, Kim Dionne, Sharon M Deml, Nancy L Wengenack, Nicole M Parrish
We examined categorical agreement between automated mycobacterial susceptibility testing methods (Mycobacterial Growth Indicator Tube [MGIT] 960 System and the VersaTREK Mycobacteria Detection and Susceptibility System) which are based on single critical concentration (CC) "breakpoints" and a commercial microbroth dilution method (Sensititre Mycobacterium tuberculosis MIC Plate [MYCOTB]) which provides an MIC value. Mycobacterium tuberculosis isolates (n=355) were tested against three first-line antimycobacterial agents (ethambutol [EMB], isoniazid [INH], rifampin [RIF]) using the MYCOTB plate and either the MGIT 960 (site 1, n=142) or VersaTREK (site 2, n=213) systems...
January 6, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29415651/integrative-analysis-of-micrornas-and-mrnas-revealed-regulation-of-composition-and-metabolism-in-nelore-cattle
#16
Gabriella B Oliveira, Luciana C A Regitano, Aline S M Cesar, James M Reecy, Karina Y Degaki, Mirele D Poleti, Andrezza M Felício, James E Koltes, Luiz L Coutinho
BACKGROUND: The amount of intramuscular fat can influence the sensory characteristics and nutritional value of beef, thus the selection of animals with adequate fat deposition is important to the consumer. There is growing knowledge about the genes and pathways that control the biological processes involved in fat deposition in muscle. MicroRNAs (miRNAs) belong to a well-conserved class of non-coding small RNAs that modulate gene expression across a range of biological functions in animal development and physiology...
February 7, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29386067/antibiotic-susceptibilities-of-indicator-bacteria-escherichia-coli-and-enterococci-spp-isolated-from-ducks-in-morogoro-municipality-tanzania
#17
Henry D Kissinga, Festo Mwombeki, Khadija Said, Abdul A S Katakweba, Hezron E Nonga, Amandus P Muhairwa
OBJECTIVE: To estimate the prevalence of antibiotic resistance in indicator bacteria Escherichia coli and Enterococci isolated from duck faeces in Morogoro Municipality, Tanzania. RESULTS: Escherichia coli and Enterococcus isolation rates from ducks faeces were 91 and 100% respectively. The prevalence of antibiotic resistance of E. coli and Enterococcus was 70.3 and 42%, respectively. E. coli resistant to four antibiotics were 28 (30.8%) and showed high resistance to ampicillin (81...
January 31, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29379897/effect-of-growth-hormone-on-uterine-receptivity-in-women-with-repeated-implantation-failure-in-an-oocyte-donation-program-a-randomized-controlled-trial
#18
Signe Altmäe, Raquel Mendoza-Tesarik, Carmen Mendoza, Nicolas Mendoza, Francesco Cucinelli, Jan Tesarik
Background and Objective: Administration of growth hormone (GH) during ovarian stimulation has been shown to improve success rates of in vitro fertilization. GH beneficial effect on oocyte quality is shown in several studies, but GH effect on uterine receptivity is not clear. To assess it, we studied whether GH administration can improve the chance of pregnancy and birth in women who experienced repeated implantation failure (RIF) using donated oocyte programs. Design and Study Population: A total of 105 infertile women were enrolled in the randomized controlled trial: 70 women were with a history of RIF with donated oocytes, and 35 infertile women underwent the first oocyte donation attempt...
January 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29374548/pirfenidone-prevents-radiation-induced-intestinal-fibrosis-in-rats-by-inhibiting-fibroblast-proliferation-and-differentiation-and-suppressing-the-tgf-%C3%AE-1-smad-ctgf-signaling-pathway
#19
Yan-Wu Sun, Yi-Yi Zhang, Xin-Jie Ke, Xue-Jing Wu, Zhi-Fen Chen, Pan Chi
Radiation-induced intestinal fibrosis (RIF) is a chronic toxicity following radiation, and can be very difficult to treat. Pirfenidone is a promising anti-fibrotic agent that inhibits fibrosis progression in various clinical and experimental studies. This study was aimed to explore whether pirfenidone could protect against RIF, and to evaluate the underlying mechanism. An animal model of RIF was induced by exposure of a single dose of 20Gy to the pelvis. Rats were orally administered with pirfenidone (200, 400 md/kg/d) for 12 weeks...
January 25, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29357810/cytochrome-p450-1a2-messenger-rna-is-a-more-reliable-marker-than-cytochrome-p450-1a2-activity-phenacetin-o-deethylation-for-assessment-of-induction-potential-of-drug-metabolizing-enzymes-using-heparg-cells
#20
Akira Ogasawara, Nozomu Kato, Nao Torimoto, Fumika Aohara, Rikiya Ohashi, Yasuhiro Yamada, Hideki Taniguchi
BACKGROUND: The HepaRG cells have key drug metabolism functionalities comparable to those of primary human hepatocytes. Many studies have reported that this cell line can be used as a reliable in vitro model for human drug metabolism studies, including the assessment of cytochrome P450 (CYP) induction. OBJECTIVES: The objective of this study is to determine whether CYP mRNA level measurement is superior to the CYP enzyme activity measurement as a convenient high-throughput method for evaluating CYP induction potential using HepaRG cells...
January 18, 2018: Drug Metabolism Letters
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