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https://www.readbyqxmd.com/read/29452422/asynchronous-and-pathological-windows-of-implantation-two-causes-of-recurrent-implantation-failure
#1
P Sebastian-Leon, N Garrido, J Remohí, A Pellicer, P Diaz-Gimeno
STUDY QUESTION: Is endometrial recurrent implantation failure (RIF) only a matter of an asynchronous (displaced) window of implantation (WOI), or could it also be a pathological (disrupted) WOI? SUMMARY ANSWER: Our predictive results demonstrate that both displaced and disrupted WOIs exist and can present independently or together in the same RIF patient. WHAT IS KNOWN ALREADY: Since 2002, many gene expression signatures associated with endometrial receptivity and RIF have been described...
February 14, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29440179/role-of-c-jun-n-terminal-kinase-in-pregnane-x-receptor-mediated-induction-of-human-cytochrome-p4503a4-in-vitro
#2
Guncha Taneja, Chun Chu, Paramahamsa Maturu, Bhagavatula Moorthy, Romi Ghose
Cytochrome P450 (CYP) 3A4 is the most abundant drug metabolizing enzyme and is responsible for the metabolism of ~50% of clinically available drugs. Induction of CYP3A4 impacts the disposition of its substrates and leads to harmful clinical consequences such as failure of therapy. In order to prevent such undesirable consequences, molecular mechanisms of regulation of CYP3A4 need to be fully understood. CYP3A4 induction is primarily regulated by the xenobiotic nuclear receptor, pregnane-X-receptor (PXR). After ligand binding, PXR is transported to the nucleus, where it binds to the CYP3A4 promoter and induces its gene expression...
February 12, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29434813/association-between-vascular-endothelial-growth-factor-promoter-polymorphisms-and-the-risk-of-recurrent-implantation-failure
#3
Sung Han Shim, Jung Oh Kim, Young Joo Jeon, Hui Jeong An, Hyun Ah Lee, Ji Hyang Kim, Eun Hee Ahn, Woo Sik Lee, Nam Keun Kim
The objective of the present study was to investigate the association between recurrent implantation failure (RIF) and vascular endothelial growth factor (VEGF) gene polymorphisms that are associated with various female infertility disorders. A total of 116 women diagnosed with RIF and 218 control subjects were genotyped for the VEGF -2578C>A, -1154G>A, -634C>G and 936C>T polymorphisms using a polymerase chain reaction-restriction fragment length polymorphism assay. The VEGF -2578AA genotype was associated with an increased prevalence (≥4) of RIF [adjusted odds ratio (AOR)=2...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29422273/automated-broth-based-systems-versus-the-mycotb-plate-for-antimicrobial-susceptibility-testing-of-the-mycobacterium-tuberculosis-complex-challenges-in-interpretation
#4
Isabella W Martin, Kim Dionne, Sharon M Deml, Nancy L Wengenack, Nicole M Parrish
We examined categorical agreement between automated mycobacterial susceptibility testing methods (Mycobacterial Growth Indicator Tube [MGIT] 960 System and the VersaTREK Mycobacteria Detection and Susceptibility System) which are based on single critical concentration (CC) "breakpoints" and a commercial microbroth dilution method (Sensititre Mycobacterium tuberculosis MIC Plate [MYCOTB]) which provides an MIC value. Mycobacterium tuberculosis isolates (n=355) were tested against three first-line antimycobacterial agents (ethambutol [EMB], isoniazid [INH], rifampin [RIF]) using the MYCOTB plate and either the MGIT 960 (site 1, n=142) or VersaTREK (site 2, n=213) systems...
January 6, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29415651/integrative-analysis-of-micrornas-and-mrnas-revealed-regulation-of-composition-and-metabolism-in-nelore-cattle
#5
Gabriella B Oliveira, Luciana C A Regitano, Aline S M Cesar, James M Reecy, Karina Y Degaki, Mirele D Poleti, Andrezza M Felício, James E Koltes, Luiz L Coutinho
BACKGROUND: The amount of intramuscular fat can influence the sensory characteristics and nutritional value of beef, thus the selection of animals with adequate fat deposition is important to the consumer. There is growing knowledge about the genes and pathways that control the biological processes involved in fat deposition in muscle. MicroRNAs (miRNAs) belong to a well-conserved class of non-coding small RNAs that modulate gene expression across a range of biological functions in animal development and physiology...
February 7, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29386067/antibiotic-susceptibilities-of-indicator-bacteria-escherichia-coli-and-enterococci-spp-isolated-from-ducks-in-morogoro-municipality-tanzania
#6
Henry D Kissinga, Festo Mwombeki, Khadija Said, Abdul A S Katakweba, Hezron E Nonga, Amandus P Muhairwa
OBJECTIVE: To estimate the prevalence of antibiotic resistance in indicator bacteria Escherichia coli and Enterococci isolated from duck faeces in Morogoro Municipality, Tanzania. RESULTS: Escherichia coli and Enterococcus isolation rates from ducks faeces were 91 and 100% respectively. The prevalence of antibiotic resistance of E. coli and Enterococcus was 70.3 and 42%, respectively. E. coli resistant to four antibiotics were 28 (30.8%) and showed high resistance to ampicillin (81...
January 31, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29379897/effect-of-growth-hormone-on-uterine-receptivity-in-women-with-repeated-implantation-failure-in-an-oocyte-donation-program-a-randomized-controlled-trial
#7
Signe Altmäe, Raquel Mendoza-Tesarik, Carmen Mendoza, Nicolas Mendoza, Francesco Cucinelli, Jan Tesarik
Background and Objective: Administration of growth hormone (GH) during ovarian stimulation has been shown to improve success rates of in vitro fertilization. GH beneficial effect on oocyte quality is shown in several studies, but GH effect on uterine receptivity is not clear. To assess it, we studied whether GH administration can improve the chance of pregnancy and birth in women who experienced repeated implantation failure (RIF) using donated oocyte programs. Design and Study Population: A total of 105 infertile women were enrolled in the randomized controlled trial: 70 women were with a history of RIF with donated oocytes, and 35 infertile women underwent the first oocyte donation attempt...
January 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29374548/pirfenidone-prevents-radiation-induced-intestinal-fibrosis-in-rats-by-inhibiting-fibroblast-proliferation-and-differentiation-and-suppressing-the-tgf-%C3%AE-1-smad-ctgf-signaling-pathway
#8
Yan-Wu Sun, Yi-Yi Zhang, Xin-Jie Ke, Xue-Jing Wu, Zhi-Fen Chen, Pan Chi
Radiation-induced intestinal fibrosis (RIF) is a chronic toxicity following radiation, and can be very difficult to treat. Pirfenidone is a promising anti-fibrotic agent that inhibits fibrosis progression in various clinical and experimental studies. This study was aimed to explore whether pirfenidone could protect against RIF, and to evaluate the underlying mechanism. An animal model of RIF was induced by exposure of a single dose of 20Gy to the pelvis. Rats were orally administered with pirfenidone (200, 400 md/kg/d) for 12 weeks...
January 25, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29357810/cytochrome-p450-1a2-messenger-rna-is-a-more-reliable-marker-than-cytochrome-p450-1a2-activity-phenacetin-o-deethylation-for-assessment-of-induction-potential-of-drug-metabolizing-enzymes-using-heparg-cells
#9
Akira Ogasawara, Nozomu Kato, Nao Torimoto, Fumika Aohara, Rikiya Ohashi, Yasuhiro Yamada, Hideki Taniguchi
BACKGROUND: The HepaRG cells have key drug metabolism functionalities comparable to those of primary human hepatocytes. Many studies have reported that this cell line can be used as a reliable in vitro model for human drug metabolism studies, including the assessment of cytochrome P450 (CYP) induction. OBJECTIVES: The objective of this study is to determine whether CYP mRNA level measurement is superior to the CYP enzyme activity measurement as a convenient high-throughput method for evaluating CYP induction potential using HepaRG cells...
January 18, 2018: Drug Metabolism Letters
https://www.readbyqxmd.com/read/29343610/cyp2j2-expression-in-adult-ventricular-myocytes-protects-against-external-and-drug-induced-ros-toxicity
#10
Eric A Evangelista, Rozenn Lemaitre, Nona Sotoodehnia, Sina Gharib, Rheem A Totah
CYP2J2 is a drug metabolizing enzyme that is highly expressed in adult ventricular myocytes. It is responsible for the bioactivation of arachidonic acid (AA) into epoxyeicosatrienoic acids (EETs). EETs are biologically active signaling compounds that protect against disease progression, particularly in cardiovascular diseases. As a drug-metabolizing enzyme, CYP2J2 is susceptible to drug interactions that could lead to cardiotoxicity. Previously, CYP2J2 has been shown to be resistant to induction by canonical CYP inducers such as phenytoin and rifampin...
January 17, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29333608/the-synergistic-effect-of-pdt-and-oxacillin-on-clinical-isolates-of-staphylococcus-aureus
#11
Natanel Iluz, Yasmin Maor, Natan Keller, Zvi Malik
BACKGROUND: Staphylococcus aureus is a major pathogen in clinical microbiology. It is known to cause infections at various body sites and can be life-threatening. The development of resistance to many well-established antibiotic treatments and the prevalence of methicillin-resistant S. aureus (MRAS) among hospital patients and the general community pose challenges in treating the pathogen. The antimicrobial effect of photodynamic therapy (PDT) has been a subject of study for a long time and can offer new strategies for dealing with resistant strains...
January 15, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29203137/mucoadhesive-chitosan-coated-solid-lipid-nanoparticles-for-better-management-of-tuberculosis
#12
Alexandre C C Vieira, Luíse L Chaves, Sara Pinheiro, Soraia Pinto, Marina Pinheiro, Sofia Costa Lima, Domingos Ferreira, Bruno Sarmento, Salette Reis
Taking into consideration the potential mucoadhesion properties of systems in lung delivery, this paper describes the preparation and characterization of chitosan-coated solid lipid nanoparticles (C-SLNs) loaded with rifampicin (RIF) as anti-tuberculosis (anti-TB) drug. The process of development and characterization of the NPs in terms of size, surface charge, encapsulation efficiency (EE), morphology, in vitro drug release, differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), in vitro assessment of mucoadhesive property, cell viability and permeability studies are documented...
December 1, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29156409/it-s-in-the-details-the-role-of-selective-discussion-in-forgetting-of-children-s-autobiographical-memories
#13
Ruth Glynn, Karen Salmon, Jason Low
This experiment investigated whether retrieval-induced forgetting (RIF) would be found in children's self-generated autobiographical memory recall. An adapted version of the RIF paradigm for adults' autobiographical memories was administered to 8- and 9-year-old children (N = 65). We hypothesized that RIF would be found in terms of both number of memories recalled and amount of memory detail reported. The relationship between memory detail at the retrieval practice phase and RIF magnitude was also investigated...
November 17, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/29147090/detection-of-antibiotic-resistance-and-resistance-genes-in-enterococci-isolated-from-sucuk-a-traditional-turkish-dry-fermented-sausage
#14
Furkan Demirgül, Yasin Tuncer
The aim of this study was to isolate enterococci in Sucuk, a traditional Turkish dry-fermented sausage and to analyze isolates for their biodiversity, antibiotic resistance patterns and the presence of some antibiotic resistance genes. A total of 60 enterococci strains were isolated from 20 sucuk samples manufactured without using a starter culture and they were identified as E. faecium (73.3%), E. faecalis (11.7%), E. hirae (8.3%), E. durans (3.3%), E. mundtii (1.7%) and E. thailandicus (1.7%). Most of the strains were found resistant to rifampin (51...
2017: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/29118904/inhibiting-post-translational-core-fucosylation-protects-against-albumin-induced-proximal-tubular-epithelial-cell-injury
#15
Dapeng Wang, Ming Fang, Nan Shen, Longkai Li, Weidong Wang, Lingyu Wang, Hongli Lin
Albuminuria is an independent risk factor for renal interstitial fibrosis (RIF). Glomerular-filtered albumin in endocytic and non-endocytic pathways may injure proximal tubular epithelial cells (PTECs) via megalin and TGFβRII, respectively. Since megalin and TGFβRII are both modified by post-translational core fucosylation, which plays a critical role in RIF. Thus, we sought to identify whether core fucosylation is a potential target for reducing albumin-induced injury to PTECs. We constructed a human PTEC-derived cell line (HK-2 cells) and established an in vitro model of bovine serum albumin (BSA) injury...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29109010/a-novel-isothermal-amplification-based-method-to-detect-mycobacterium-tuberculosis-complex
#16
Dongxin Liu, Bing Zhao, Xichao Ou, Huiwen Zheng, Aijing Ma, Wencong He, Shengfen Wang, Yang Zhou, Hui Xia, Yang Zheng, Ping Hou, Guangxue He, Yanlin Zhao
Mycobacterium tuberculosis (MTB) is the causative agent of pulmonary tuberculosis. Rapid and accurate diagnosis is crucial to tuberculosis control and prevention. A series of diagnostic methods has been available for MTB detection; however, new rapid, simple and affordable methods are needed. In this study, a multiple cross displacement amplification (MCDA)-based assay was developed to detect the IS6110 gene of the M. tuberculosis complex. Hydroxy naphthol blue (HNB), a colorimetric indicator, was used to detect amplification products...
November 3, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29108951/automated-time-lapse-microscopy-a-novel-method-for-screening-of-antibiotic-combination-effects-against-multidrug-resistant-gram-negative-bacteria
#17
W Ungphakorn, P Lagerbäck, E I Nielsen, T Tängdén
OBJECTIVES: Antibiotic combinations are often used for carbapenemase-producing Enterobacteriaceae (CPE) but more data are needed on the optimal selection of drugs. This study aimed to evaluate the feasibility of a novel automated method based on time-lapse microscopy (the oCelloScope, Philips BioCell A/S, Allerød, Denmark) to determine in vitro combination effects against CPE and to discuss advantages and limitations of the oCelloScope in relation to standard methods. METHODS: Four Klebsiella pneumoniae and two Escherichia coli were exposed to colistin, meropenem, rifampin and tigecycline, alone and in combination...
November 3, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29096559/retinoic-acid-receptors-%C3%AE-and-%C3%AE-are-involved-in-antioxidative-protection-in-renal-tubular-epithelial-cells-injury-induced-by-hypoxia-reoxygenation
#18
Ling Jiang, Yuanhan Qin, Fengying Lei, Xiuping Chen, Zhiqiang Zhou
Renal interstitial fibrosis (RIF) is a common outcome in various chronic kidney diseases. Injury to renal tubular epithelial cell (RTEC) is major link in RIF. Hypoxia is one of the common factors for RTEC damage. Retinoic acid receptors (RARs), RARα, RARβ and RARγ, are evolutionary conserved and pleiotropic proteins that have been involved in various cellular functions, including proliferation, differentiation, apoptosis, and transcription. Recently, we discovered that aberrant expression of RARs was involved in the development of RIF in rats...
November 3, 2017: Free Radical Research
https://www.readbyqxmd.com/read/29034173/mycobacteria-bovis-osteomyelitis-following-intravesical-bcg-for-bladder-cancer
#19
Karan Seegobin, Satish Maharaj, Cherisse Baldeo, Carmen Isache, Bharatsinh Gharia, Lara Zuberi
Mycobacteria Bovis osteomyelitis is a rare adverse effect after Bacillus Calmette-Guerin (BCG) intravesical therapy. A 62-year-old male presented with acute spinal cord compression three months after completing his second course of therapy for bladder cancer. The first course with intravesical BCG was complicated with an episode of hematuria. He reported intermittent subjective fever for 3 weeks thereafter which resolved with Tylenol. Interferon-α2 B was added to the second cycle of intravesical BCG with the indication here being residual tumor, and was tolerated well...
2017: IDCases
https://www.readbyqxmd.com/read/29026323/diagnostic-accuracy-of-xpert-mtb-rif-assay-for-musculoskeletal-tuberculosis-a-meta-analysis
#20
REVIEW
Hai Wen, Pengzhi Li, Hong Ma, Guohua Lv
OBJECTIVES: Xpert MTB/RIF assay, a rapid and automated real-time nucleic acid amplification test, has been reported for the diagnosis of musculoskeletal tuberculosis (TB) in current years. This meta-analysis aims to determine the diagnostic accuracy of Xpert for the detection of musculoskeletal TB and rifampicin (RIF) resistance. METHODS: We searched PubMed, Embase, China National Knowledge Infrastructure, and Wanfang for original articles published up to 1st June 2017 to identify studies in which the Xpert assay was applied to diagnose musculoskeletal TB...
2017: Infection and Drug Resistance
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