Yingda L Xie, Christie Eichberg, Nchimunya Hapeela, Elizabeth Nakabugo, Irene Anyango, Kiranjot Arora, Jeffrey E Korte, Ronald Odero, Judi van Heerden, Widaad Zemanay, Samuel Kennedy, Pamela Nabeta, Mahmud Hanif, Camilla Rodrigues, Alena Skrahina, Wendy Stevens, Reynaldo Dietze, Xin Liu, Jerrold J Ellner, David Alland, Moses L Joloba, Samuel G Schumacher, Kimberly D McCarthy, Lydia Nakiyingi, Susan E Dorman
BACKGROUND: Xpert MTB/RIF Ultra (Ultra) is an automated molecular test for the detection of Mycobacterium tuberculosis in sputum. We compared the sensitivity of Ultra to that of mycobacterial growth indicator tube (MGIT) liquid culture, considered the most sensitive assay in routine clinical use. METHODS: In this prospective, multicentre, cross-sectional diagnostic accuracy study, we used a non-inferiority design to assess whether the sensitivity of a single Ultra test was non-inferior to that of a single liquid culture for detection of M tuberculosis in sputum...
April 9, 2024: The Lancet. Microbe