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https://www.readbyqxmd.com/read/29147957/mobilization-of-endothelial-progenitor-cell-in-patients-with-acute-ischemic-stroke
#1
Yushuang Deng, Jian Wang, Guiqiong He, Fei Qu, Min Zheng
Endothelial progenitor cells (EPCs) have important effect in tissue repair in ischemic organs. The present study was conducted to demonstrate the mobilization of EPCs and its possible mechanism after acute ischemic stroke (AIS). A total of 148 individuals were examined, including 106 patients with ischemic stroke and 42 healthy controls. Seventy-one patients with imaging-confirmed AIS were examined at days 1, 7, 14, and 21 after stroke onset. Circulating EPCs were quantified by flow cytometry using CD133 and KDR surface markers...
November 16, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29147735/reduction-of-metallic-artifacts-of-the-post-treatment-intracranial-aneurysms-effects-of-single-energy-metal-artifact-reduction-algorithm
#2
Yu-Ning Pan, Ge Chen, Ai-Jing Li, Zhao-Qian Chen, Xiang Gao, Yi Huang, Bradley Mattson, Shan Li
PURPOSE: This study evaluated the quality of computed tomography (CT) and CT angiography images generated using the single-energy metal artifact reduction (SEMAR) algorithm during perfusion examination in patients who had undergone reconstruction with neurosurgical clipping or endovascular coiling for treatment of aneurysms. METHODS: A total of 55 patients with implanted intracranial clips or coils (24 men and 31 women; mean age 60.15 ± 15.86 years) underwent perfusion studies evaluated by CT and CT angiography with a 320-row CT scanner...
November 16, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/29145824/observations-on-significant-hemodynamic-changes-caused-by-a-high-concentration-of-epidurally-administered-ropivacaine-correlation-and-prediction-study-of-stroke-volume-variation-and-central-venous-pressure-in-thoracic-epidural-anesthesia
#3
Jeong-Min Hong, Hyeon Jeong Lee, Young-Jae Oh, Ah Rhem Cho, Hyae Jin Kim, Do-Won Lee, Wang-Seok Do, Jae-Young Kwon, Haekyu Kim
BACKGROUND: Thoracic epidural anesthesia (TEA) exacerbates hypotension due to peripheral vasodilator effects following the use of general anesthetics. This study aimed to compare the hemodynamic changes caused by three different concentrations of epidural ropivacaine and to evaluate the performance of the stroke-volume variation (SVV) and central venous pressure (CVP) during TEA with general anesthesia. METHODS: A total of 120 patients were administered 8 mL of ropivacaine solution via epidural injection, following randomization into one of three groups based on the concentration of ropivacaine in the study solution: 0...
November 16, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/29145478/electrical-impedance-tomography-amplitudes-of-cardiac-related-impedance-changes-in-the-lung-are-highly-position-dependent
#4
Michael Graf, Thomas Riedel
BACKGROUND: Electrical impedance tomography (EIT) is used on the thorax to measure impedance changes due to the presence of air and blood in the lung. This experimental study was performed to investigate the effect of posture on cardiac and respiratory related impedance changes. METHODS: EIT measurements were performed on 14 healthy subjects in left-, right lateral, prone, supine and upright positions. Simultaneously, tidal volume was recorded with an ultrasonic flowmeter...
2017: PloS One
https://www.readbyqxmd.com/read/29145198/heavy-alcohol-consumption-effects-on-blood-pressure-and-on-kidney-structure-persist-after-long-term-withdrawal
#5
Sandra Leal, Dinis-Oliveira Ricardo Jorge, Barbosa Joana, Silva Susana Maria, Sá Susana Isabel
BACKGROUND/AIMS: Heavy ethanol consumption is a risk factor for hypertension and prompts organ damage. There is no information regarding the impact of long-term heavy ethanol consumption on kidney structure and function linking to their hypertensive effects nor the repercussions after withdrawal. METHODS: Rats were exposed to ethanol for 24 weeks and, afterwards, a group was assigned to withdrawal for 8 weeks. Blood pressure (BP) was measured and serum biochemical parameters were quantified...
November 21, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29144161/use-of-patient-outcome-endpoints-to-identify-the-best-functional-ct-imaging-parameters-in-metastatic-renal-cell-carcinoma-patients
#6
Jill Rachel Mains, Frede Donskov, Erik Morre Petersen, Hans Henrik Torp Madsen, Jesper Thygesen, Kennet Thorup, Finn Rasmussen
OBJECTIVE: To use the patient outcome endpoints overall survival and progression-free survival to evaluate functional parameters derived from dynamic contrast-enhanced computed tomography (DCE-CT). METHODS: 69 patients with metastatic renal cell carcinoma (mRCC) had DCE-CT scans at baseline and after 5 and 10 weeks of treatment. Blood volume, blood flow and standardized perfusion values were calculated using deconvolution (BVdeconv, BFdeconv and SPVdeconv), blood flow and standardized perfusion values using maximum slope (BFmax and SPVmax), and blood volume and permeability surface area product using the Patlak model (BVpatlak and PS)...
November 16, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29141489/non-linear-conversion-of-hx4-uptake-for-automatic-segmentation-of-hypoxic-volumes-and-dose-prescription
#7
Ana Ureba, Emely Lindblom, Alexandru Dasu, Johan Uhrdin, Aniek J G Even, Wouter van Elmpt, Philippe Lambin, Peter Wersäll, Iuliana Toma-Dasu
BACKGROUND: Tumour hypoxia is associated with increased radioresistance and poor response to radiotherapy. Pre-treatment assessment of tumour oxygenation could therefore give the possibility to tailor the treatment by calculating the required boost dose needed to overcome the increased radioresistance in hypoxic tumours. This study concerned the derivation of a non-linear conversion function between the uptake of the hypoxia-PET tracer (18)F-HX4 and oxygen partial pressure (pO2). MATERIAL AND METHODS: Building on previous experience with FMISO including experimental data on tracer uptake and pO2, tracer-specific model parameters were derived for converting the normalised HX4-uptake at the optimal imaging time point to pO2...
November 16, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29139146/effects-of-the-sodium-glucose-cotransporter-2-sglt2-inhibitor-velagliflozin-a-new-drug-with-therapeutic-potential-to-treat-diabetes-in-cats
#8
M Hoenig, M Clark, D J Schaeffer, D Reiche
Sodium-glucose cotransporter 2 (SGLT2) inhibitors are used in the treatment of human diabetics. They increase glucose excretion and correct hyperglycemia. We examined the investigational SGLT2 inhibitor velagliflozin in two groups of six neutered adult obese cats (equal gender distribution). Placebo (Pl) or drug (D; 1 mg/kg) was administered for 35 days. Routine blood examinations, fructosamine, beta-hydroxybutyrate (BHB), nonesterified fatty acids (NEFA), glucagon, adiponectin, and leptin were measured before and after treatment, also water intake, and urinary electrolytes, glucose, and volume...
November 15, 2017: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29138527/longitudinal-analysis-of-mouse-sdoct-volumes
#9
Bhavna J Antony, Aaron Carass, Andrew Lang, Byung-Jin Kim, Donald J Zack, Jerry L Prince
Spectral-domain optical coherence tomography (SDOCT), in addition to its routine clinical use in the diagnosis of ocular diseases, has begun to find increasing use in animal studies. Animal models are frequently used to study disease mechanisms as well as to test drug efficacy. In particular, SDOCT provides the ability to study animals longitudinally and non-invasively over long periods of time. However, the lack of anatomical landmarks makes the longitudinal scan acquisition prone to inconsistencies in orientation...
February 11, 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/29137853/antidiabetic-antihyperlipidemic-activities-and-herb-drug-interaction-of-a-polyherbal-formulation-in-streptozotocin
#10
Vishnu P Choudhari, Ketkee P Gore, Anil T Pawar
BACKGROUND: Ojamin (OJ), a polyherbal antidiabetic formulation, is extensively used as a food supplement to control diabetes alone or along with synthetic antidiabetic agents. However, it's phytochemical and pharmacological investigations are lacking. OBJECTIVE: The present study was undertaken to study antidiabetic and antihyperlipidemic potentials of OJ and its interaction with Metformin in streptozotocin (STZ)-induced diabetic rats. MATERIALS AND METHODS: Diabetes was induced in Wistar rats by single intraperitoneal (i...
November 11, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/29135072/measuring-human-placental-blood-flow-with-multidelay-3d-grase-pseudocontinuous-arterial-spin-labeling-at-3t
#11
Xingfeng Shao, Dapeng Liu, Thomas Martin, Teresa Chanlaw, Sherin U Devaskar, Carla Janzen, Aisling M Murphy, Daniel Margolis, Kyunghyun Sung, Danny J J Wang
BACKGROUND: Placenta influences the health of both a woman and her fetus during pregnancy. Maternal blood supply to placenta can be measured noninvasively using arterial spin labeling (ASL). PURPOSE: To present a multidelay pseudocontinuous arterial spin labeling (pCASL) combined with a fast 3D inner-volume gradient- and spin-echo (GRASE) imaging technique to simultaneously measure placental blood flow (PBF) and arterial transit time (ATT), and to study PBF and ATT evolution with gestational age during the second trimester...
November 14, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29133146/association-of-genetic-polymorphisms-with-erythrocyte-traits-verification-of-snps-reported-in-a-previous-gwas-in-a-japanese-population
#12
Toshio Seiki, Mariko Naito, Asahi Hishida, Sahoko Takagi, Takashi Matsunaga, Tae Sasakabe, Yuta Hattori, Sayo Kawai, Rieko Okada, Guang Yin, Nobuyuki Hamajima, Kenji Wakai
Erythrocyte count and volume are the commonly used hematological indices for anemia that change in various diseases. To date, however, only one study ever exists that addressed erythrocyte trait-associated single nucleotide polymorphisms (SNPs) in a Japanese population. Because that study was performed in patients with various diseases, we confirmed the reported associations in a general population. Participants in the current study were from the Shizuoka component of the Japan Multi-Institutional Collaborative Cohort Study, which included 4971 men and women aged 35 to 69years who were recruited between 2006 and 2007...
November 10, 2017: Gene
https://www.readbyqxmd.com/read/29133109/temporal-gradient-during-famous-face-naming-is-associated-with-lower-cerebral-blood-flow-and-gray-matter-volume-in-aging
#13
Chelsea C Hays, Zvinka Z Zlatar, Laura Campbell, M J Meloy, Christina E Wierenga
OBJECTIVE: Evidence suggests that famous face naming may be a cognitive ability especially sensitive to the early pathological processes of Alzheimer's disease (AD) and that those at risk for AD may demonstrate a Ribot temporal gradient (RTG), characterized by better performance for naming remote famous faces than for naming recent famous faces. Reductions in cerebral blood flow (CBF) and gray matter volume (GMV) have been implicated in the neuropathological cascade of AD and show utility as biomarkers of AD risk...
November 10, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/29132545/nanoformulation-a-useful-therapeutic-strategy-for-improving-neuroprotection-and-the-neurorestorative-potential-in-experimental-models-of-parkinson-s-disease
#14
Jose V Lafuente, Catalina Requejo, Alejandro Carrasco, Harkaitz Bengoetxea
Parkinson's disease (PD) is the second most frequent neurodegenerative disorder, but current therapies are only symptomatic. Experimental models are necessary to go deeper in the comprehension of pathophysiological mechanism and to assess new therapeutic strategies. The unilateral 6-hydroxydopamine (6-OHDA) lesion either in medial forebrain bundle (MFB) or into the striatum in rats affords to study various stages of PD depending on the evolution time lapsed. A promising alternative to address the neurodegenerative process is the use of neurotrophic factors; but its clinical use has been limited due to its short half-life and rapid degradation after in vivo administration, along with difficulties for crossing the blood-brain barrier (BBB)...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/29131826/an-interactive-sports-video-game-as-an-intervention-for-rehabilitation-of-community-living-patients-with-schizophrenia-a-controlled-single-blind-crossover-study
#15
Nobuko Shimizu, Tomohiro Umemura, Masahiro Matsunaga, Takayoshi Hirai
Hypofrontality is a state of decreased cerebral blood flow in the prefrontal cortex during executive function performance; it is commonly observed in patients with schizophrenia. Cognitive dysfunction, as well as the psychological symptoms of schizophrenia, influences the ability of patients to reintegrate into society. The current study investigated the effects of an interactive sports video game (IVG; Nintendo Wii™ Sports Resort) on frontal lobe function of patients with schizophrenia. A sample of eight patients (6 male and 2 female; mean age = 46...
2017: PloS One
https://www.readbyqxmd.com/read/29131520/near-infrared-human-finger-measurements-based-on-self-calibration-point-simulation-and-in-vivo-experiments
#16
Hamootal Duadi, Idit Feder, Dror Fixler
Near-infrared light allows measuring tissue oxygenation. These measurements relay on oxygenation dependent absorption spectral changes. However, the tissue scattering, which is also spectral dependent, introduces an intrinsic error. Most methods focus on the volume reflectance from a semi-infinite sample. We have proposed examining the full scattering profile (FSP), which is the angular intensity distribution. A point was found, i.e. the iso-pathlength (IPL) point, which is not dependent on the tissue scattering, and can serve for self-calibration...
November 13, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/29129925/the-neural-basis-of-homeostatic-and-anticipatory-thirst
#17
REVIEW
Claire Gizowski, Charles W Bourque
Water intake is one of the most basic physiological responses and is essential to sustain life. The perception of thirst has a critical role in controlling body fluid homeostasis and if neglected or dysregulated can lead to life-threatening pathologies. Clear evidence suggests that the perception of thirst occurs in higher-order centres, such as the anterior cingulate cortex (ACC) and insular cortex (IC), which receive information from midline thalamic relay nuclei. Multiple brain regions, notably circumventricular organs such as the organum vasculosum lamina terminalis (OVLT) and subfornical organ (SFO), monitor changes in blood osmolality, solute load and hormone circulation and are thought to orchestrate appropriate responses to maintain extracellular fluid near ideal set points by engaging the medial thalamic-ACC/IC network...
November 13, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29128573/26-week-oral-chronic-toxicity-study-of-geniposide-in-rats
#18
Jingzhuo Tian, Yan Yi, Yong Zhao, Chunying Li, Yushi Zhang, Lianmei Wang, Chen Pan, Jiayin Han, Guiqin Li, Xiaolong Li, Jing Liu, Nuo Deng, Yue Gao, Aihua Liang
ETHNOPHARMACOLOGICAL RELEVANCE: Geniposide, the major active constituent of Fructus Gardeniae (FG), has been widely used to treat the various diseases in China. AIM OF THE STUDY: The chronic toxicity study was conducted to investigate the safety of Geniposide. MATERIALS AND METHODS: Sprague-Dawley (SD) rats of both sexes were administered orally Geniposide 25, 50, 100mg/kg by gavage once daily at volume of 10mL/kg for 26 weeks repeated. Endpoints evaluated included clinical observations, food consumption, body weights, blood biochemistry, hematology, and histomorphological observation...
November 8, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29127619/changes-in-the-lung-bacteriome-in-relation-to-antipseudomonal-therapy-in-children-with-cystic-fibrosis
#19
Lenka Kramná, Pavel Dřevínek, Jake Lin, Michal Kulich, Ondrej Cinek
The lung in cystic fibrosis (CF) is home to numerous pathogens that shorten the lives of patients. The aim of the present study was to assess changes in the lung bacteriome following antibiotic therapy targeting Pseudomonas aeruginosa in children with CF. The study included nine children (9-18 years) with CF who were treated for their chronic or intermittent positivity for Pseudomonas aeruginosa. The bacteriomes were determined in 16 pairs of sputa collected at the beginning and at the end of a course of intravenous antibiotic therapy via deep sequencing of the variable region 4 of the 16S rRNA gene, and the total bacterial load and selected specific pathogens were assessed using quantitative real-time PCR...
November 10, 2017: Folia Microbiologica
https://www.readbyqxmd.com/read/29125704/left-atrial-ejection-force-predicts-the-outcome-after-catheter-ablation-for-paroxysmal-atrial-fibrillation
#20
Hideyuki Kishima, Takanao Mine, Satoshi Takahashi, Kenki Ashida, Masaharu Ishihara, Tohru Masuyama
INTRODUCTION: Left atrium (LA) systolic dysfunction is observed in the early stages of atrial fibrillation (AF) prior to LA anatomical change. We investigated whether LA systolic dysfunction predicts recurrent AF after catheter ablation (CA) in patients with paroxysmal AF. METHODS AND RESULTS: We studied 106 patients who underwent CA for paroxysmal AF. LA systolic function was assessed with the LA emptying volume = Maximum LA volume (LAVmax) - Minimum LA volume (LAVmin), LA emptying fraction = [(LAVmax - LAVmin) / LAVmax] × 100, and LA ejection force calculated with Manning`s method [LA ejection force = (0...
November 10, 2017: Journal of Cardiovascular Electrophysiology
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