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https://www.readbyqxmd.com/read/28087835/study-of-tio2-p25-nanoparticles-genotoxicity-on-lung-blood-and-liver-cells-in-lung-overload-and-non-overload-conditions-after-repeated-respiratory-exposure-in-rats
#1
Charlène Relier, Marielle Dubreuil, Omar Lozano Garcia, Eugenia Cordelli, Jorge Mejia, Patrizia Eleuteri, Franck Robidel, Thomas Loret, Francesca Pacchierotti, Stéphane Lucas, Ghislaine Lacroix, Bénédicte Trouiller
Inhaled titanium dioxide (TiO2) nanoparticles (NPs) can have negative health effects, and have been shown to cause respiratory tract cancer in rats. Inflammation has been linked to oxidative stress, and both have been described as possible mechanisms for genotoxicity of NPs, but rarely examined side-by-side in animal studies. In the present study, a wide range of complementary endpoints have been performed to study TiO2 P25 NP-induced genotoxicity in lung overload and non-overload conditions. Additionally, lung burden, inflammation, cytotoxicity and oxidative stress have also been evaluated in order to link genotoxicity with these responses...
January 13, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28079876/cardiac-output-decreases-and-systemic-vascular-resistance-increases-in-newborns-placed-in-the-left-lateral-position
#2
G Paviotti, S Todero, S Demarini
OBJECTIVE: The objective of the study was to study the effect of short-term left-lateral position on cardiovascular parameters in hemodynamically stable newborns. STUDY DESIGN: Cardiac output (CO), stroke volume (SV), systemic vascular resistance index (SVRI) and heart rate (HR) were measured by electric velocimetry in hemodynamically stable newborns without respiratory support in the supine, left-lateral and back-to-supine positions, each kept for 10 min. RESULTS: Thirty-two newborns were enrolled, birth weight 2134 (1818 to 2460) g, gestational age 34...
January 12, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28079655/microarchitecture-of-schlemm-canal-before-and-after-selective-laser-trabeculoplasty-in-enhanced-depth-imaging-optical-coherence-tomography
#3
Alon Skaat, Michael S Rosman, Jason L Chien, Mark P Ghassibi, Jeffrey M Liebmann, Robert Ritch, Sung Chul Park
PURPOSE: To characterize the in vivo effect of selective laser trabeculoplasty (SLT) on the Schlemm canal (SC) in eyes with primary open-angle glaucoma (POAG). MATERIALS AND METHODS: Eighty-one serial horizontal enhanced depth imaging optical coherence tomograph B-scans (interval between B-scans, ∼35 μm) of the nasal corneoscleral limbus were obtained before and 4 weeks after SLT. Fifty B-scans in the overlapping regions before and after SLT were selected for analysis based on the structures of aqueous and blood vessels as landmarks...
January 10, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28079628/interleukin-6-is-increased-in-plasma-and-cerebrospinal-fluid-of-community-dwelling-domestic-dogs-with-acute-ischaemic-stroke
#4
Hanne Gredal, Barbara B Thomsen, Antonio Boza-Serrano, Laurent Garosi, Clare Rusbridge, Daniel Anthony, Arne Møller, Bente Finsen, Tomas Deierborg, Kate L Lambertsen, Mette Berendt
Inflammatory cytokines are potential modulators of infarct progression in acute ischaemic stroke, and are therefore possible targets for future treatment strategies. Cytokine studies in animal models of surgically induced stroke may, however, be influenced by the fact that the surgical intervention itself contributes towards the cytokine response. Community-dwelling domestic dogs suffer from spontaneous ischaemic stroke, and therefore, offer the opportunity to study the cytokine response in a noninvasive set-up...
January 10, 2017: Neuroreport
https://www.readbyqxmd.com/read/28079397/mixed-compared-with-single-source-proteins-in-high-protein-diets-affect-kidney-structure-and-function-differentially-in-obese-fa-fa-zucker-rats
#5
Jessay G Devassy, Jennifer L Wojcik, Naser H M Ibrahim, Peter Zahradka, Carla G Taylor, Harold M Aukema
Questions remain regarding the potential negative effects of dietary high protein (HP) on kidney health, particularly in the context of obesity in which the risk for renal disease is already increased. To examine whether some of the variability in HP effects on kidney health may be due to source of protein, obese fa/fa Zucker rats were given HP (35% of energy from protein) diets containing either casein, soy protein, or a mixed source of animal and plant proteins for 12 weeks. Control lean and obese rats were given diets containing casein at normal protein (15% of energy from protein) levels...
October 6, 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28078626/time-course-investigation-of-blood-brain-barrier-permeability-and-tight-junction-protein-changes-in-a-rat-model-of-permanent-focal-ischemia
#6
Peng Liu, Rui Zhang, Danyang Liu, Jinling Wang, Chunling Yuan, Xuemei Zhao, Yinjie Li, Xuefei Ji, Tianyan Chi, Libo Zou
Permanent middle cerebral artery occlusion (pMCAO) is an animal model that is widely used to simulate human ischemic stroke. However, the timing of the changes in the expression of tight junction (TJ) proteins and synaptic proteins associated with pMCAO remain incompletely understood. Therefore, to further explore the characteristics and mechanisms of blood-brain barrier (BBB) damage during cerebral ischemic stroke, we used a pMCAO rat model to define dynamic changes in BBB permeability within 120 h after ischemia in order to examine the expression levels of the TJ proteins claudin-5 and occludin and the synaptic proteins synaptophysin (SYP) and postsynaptic density protein 95 (PSD95)...
January 11, 2017: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/28077530/impact-of-balanced-tetrastarch-raw-material-on-perioperative-blood-loss-a-randomized-double-blind-controlled-trial
#7
A Joosten, R Tircoveanu, S Arend, P Wauthy, P Gottignies, P Van der Linden
BACKGROUND: As 6% hydroxyethyl starch (HES) 130/0.40 or 130/0.42 can originate from different vegetable sources, they might have different clinical effects. The purpose of this prospective, randomized, double-blind controlled trial was to compare two balanced tetrastarch solutions, one maize-derived and one potato-derived, on perioperative blood loss in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). METHODS: We randomly assigned 118 patients undergoing elective cardiac surgery into two groups, to receive either a maize- or a potato-derived HES solution...
October 2016: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28077286/assessment-of-neuroanatomical-and-behavioural-effects-of-in-ovo-methylmercury-exposure-in-zebra-finches-taeniopygia-guttata
#8
Maria S Yu, Margaret L Eng, Tony D Williams, Mélanie F Guigueno, John E Elliott
Methylmercury (MeHg) readily crosses the blood brain barrier and is a known neuro-toxicant. MeHg accumulation in the brain causes histopathological alterations, neurobehavioral changes, and impairments to cognitive motor functions in mammalian models. However, in birds the neurotoxic effects of MeHg on the developing pre-hatching brain and consequent behavioral alterations in adult birds have not received much attention. Moreover, passerine birds are poorly represented in MeHg neurotoxicology studies in comparison to other avian orders...
January 7, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28075489/cough-augmentation-techniques-for-extubation-or-weaning-critically-ill-patients-from-mechanical-ventilation
#9
REVIEW
Louise Rose, Neill Kj Adhikari, David Leasa, Dean A Fergusson, Douglas McKim
BACKGROUND: There are various reasons why weaning and extubation failure occur, but ineffective cough and secretion retention can play a significant role. Cough augmentation techniques, such as lung volume recruitment or manually- and mechanically-assisted cough, are used to prevent and manage respiratory complications associated with chronic conditions, particularly neuromuscular disease, and may improve short- and long-term outcomes for people with acute respiratory failure. However, the role of cough augmentation to facilitate extubation and prevent post-extubation respiratory failure is unclear...
January 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28075072/use-of-erythrocyte-indicators-of-health-and-condition-in-vertebrate-ecophysiology-a-review-and-appraisal
#10
Christopher P Johnstone, Alan Lill, Richard D Reina
We review evidence for and against the use of erythrocyte indicators of health status and condition, parasite infection level and physiological stress in free-living vertebrates. The use of indicators that are measured directly from the blood, such as haemoglobin concentration, haematocrit and erythrocyte sedimentation rate, and parameters that are calculated from multiple measured metrics, such as mean cell volume, mean cell haemoglobin content or mean cell haemoglobin concentration is evaluated. The evidence for or against the use of any given metric is equivocal when the relevant research is considered in total, although there is sometimes strong support for using a particular metric in a particular taxon...
February 2017: Biological Reviews of the Cambridge Philosophical Society
https://www.readbyqxmd.com/read/28074419/deciphering-the-molecular-mechanisms-involved-in-hiv-associated-lipoatrophy-by-transcriptomics-a-pilot-study
#11
Patricia Pérez-Matute, María Iñiguez, Emma Recio-Fernández, José-Antonio Oteo
HIV-associated lipoatrophy (LA) has considerable implications for risk of metabolic diseases, quality of life, and adherence to treatments. Although it has decreased in high-income countries, it is still very common in resource-limited countries. Understanding the pathophysiological mechanisms of LA can open the possibility to explore new ways to treat or prevent this condition. To identify new markers for an accurate and quick diagnosis will be also of interest. Thus, we aimed to examine functional classes of genes implicated in LA and to identify potential new markers for an accurate/quick diagnosis of LA and future complications...
January 10, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28070107/effects-of-reduced-food-intake-for-4-weeks-on-physiological-parameters-in-toxicity-studies-in-dogs
#12
Junya Morita, Tomoko Izumi, Bunichiro Ogawa, Yoshiki Ban, Hironori Takagi, Minoru Sasaki, Shunsuke Tsutsumi
This study sought to clarify the effects of reduced feeding on physiological parameters in dogs to enable appropriate evaluations of the safety and toxicity of test compounds. We measured alkaline phosphatase isozymes and the circulating blood volume, as well as clinical signs, body weight, hematology, blood chemistry, electrocardiography, organ weight, and histopathology, in male beagle dogs fed a diet consisting of 300 g/day or 150 g/day for 4 weeks. There were no abnormal clinical signs in any of the dogs...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/28068238/hematologic-nadirs-during-chemoradiation-for-anal-cancer-temporal-characterization-and-dosimetric-predictors
#13
Andrew Y Lee, Daniel W Golden, Jose G Bazan, Malgorzata Kopec, Charles A Pelizzari, Sonya Aggarwal, Daniel T Chang, Stanley L Liauw
PURPOSE: Pelvic bone marrow (BM) constraints may offer a means to reduce the toxicity commonly associated with chemoradiation for anal cancer. We conducted a bi-institutional analysis of dose-volume metrics in a time-sensitive fashion to devise practical metrics to minimize hematologic toxicity. METHODS AND MATERIALS: Fifty-six anal cancer patients from 2 institutions received definitive radiation therapy (median primary dose of 54 Gy) using intensity modulated radiation therapy (IMRT, n=49) or 3-dimensional (3D) conformal therapy (n=7) with concurrent 5-fluorouracil (5-FU) and mitomycin C...
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28067724/acute-central-serous-chorioretinopathy-factors-influencing-episode-duration
#14
Alejandra Daruich, Alexandre Matet, Laetitia Marchionno, Jean-Dominique De Azevedo, Aude Ambresin, Irmela Mantel, Francine Behar-Cohen
PURPOSE: To evaluate the influence of clinical and multimodal imaging parameters on the duration of acute central serous chorioretinopathy (CSCR) episodes. METHODS: Consecutive patients with first, treatment-naïve central serous chorioretinopathy episodes presenting within 20 days of symptoms onset were prospectively included. They were reevaluated 15 days to 20 days later, followed by monthly evaluation for 6 months. Subfoveal choroidal thickness (SFCT), fluorescein leakage intensity on fluorescein angiography, elevation of retinal pigment epithelium (RPE) lesions at leakage sites, focal/multifocal pattern of indocyanine green angiography (ICGA) at baseline, time-dependent pattern of subretinal fluid (SRF) resorption on OCT using volume segmentation, history of corticosteroid intake and mean blood pressure were evaluated using univariate (Log rank test) and multivariate (Cox proportional hazard regression) survival analysis...
January 6, 2017: Retina
https://www.readbyqxmd.com/read/28065166/the-predictive-capabilities-of-a-novel-cardiovascular-magnetic-resonance-derived-marker-of-cardiopulmonary-reserve-on-established-prognostic-surrogate-markers-in-patients-with-pulmonary-vascular-disease-results-of-a-longitudinal-pilot-study
#15
Timothy J Baillie, Samuel Sidharta, Peter M Steele, Stephen G Worthley, Scott Willoughby, Karen Teo, Prashanthan Sanders, Stephen J Nicholls, Matthew I Worthley
BACKGROUND: No unified method exists to effectively predict and monitor progression of pulmonary arterial hypertension (PAH). We assessed the longitudinal relationship between a novel marker of cardiopulmonary reserve and established prognostic surrogate markers in patients with pulmonary vascular disease. METHODS AND RESULTS: Twenty participants with confirmed (n = 14) or at high risk (n = 6) for PAH underwent cardiovascular magnetic resonance (CMR) at baseline and after ~6 months of guideline-appropriate management...
January 9, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28063459/cardiac-remodeling-following-reperfused-acute-myocardial-infarction-is-linked-to-the-concomitant-evolution-of-vascular-function-as-assessed-by-cardiovascular-magnetic-resonance
#16
Olivier Huttin, Damien Mandry, Romain Eschalier, Lin Zhang, Emilien Micard, Freddy Odille, Marine Beaumont, Renaud Fay, Jacques Felblinger, Edoardo Camenzind, Faïez Zannad, Nicolas Girerd, Pierre Y Marie
BACKGROUND: Left ventricular (LV) remodeling following acute myocardial infarction (MI) is difficult to predict at an individual level although a possible interfering role of vascular function has yet to be considered to date. This study aimed to determine the extent to which this LV remodeling is influenced by the concomitant evolution of vascular function and LV loading conditions, as assessed by phase-contrast Cardiovascular Magnetic Resonance (CMR) of the ascending aorta. METHODS: CMR was performed in 121 patients, 2-4 days after reperfusion of a first ST-segment elevation myocardial infarction and 6 months thereafter...
January 4, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28062134/vascular-expansion-during-worsening-of-heart-failure-effects-on-clinical-features-and-its-determinants
#17
Hajime Kataoka
BACKGROUND: This study investigated the relation of the changes in serum solutes/albumin to the level of vascular expansion and clinical features during worsening HF. METHODS: Data from 47 patients with acute on chronic HF worsening were analyzed. Blood tests included hemoglobin, hematocrit, albumin, solutes (Na/K/Cl/BUN/Cr), and b-type natriuretic peptide (BNP). The relative change in the vascular expansion from stable to worsening HF was estimated based on changes in the plasma volume (%PV)...
December 27, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28059661/intravenous-infusion-of-mesenchymal-stem-cells-inhibits-intracranial-hemorrhage-after-recombinant-tissue-plasminogen-activator-therapy-for-transient-middle-cerebral-artery-occlusion-in-rats
#18
Masahito Nakazaki, Masanori Sasaki, Yuko Kataoka-Sasaki, Shinichi Oka, Takahiro Namioka, Ai Namioka, Rie Onodera, Junpei Suzuki, Yuichi Sasaki, Hiroshi Nagahama, Takeshi Mikami, Masahiko Wanibuchi, Jeffery D Kocsis, Osamu Honmou
OBJECTIVE Reperfusion therapy with intravenous recombinant tissue plasminogen activator (rtPA) is the standard of care for acute ischemic stroke. However, hemorrhagic complications can result. Intravenous infusion of mesenchymal stem cells (MSCs) reduces stroke volume and improves behavioral function in experimental stroke models. One suggested therapeutic mechanism is inhibition of vascular endothelial dysfunction. The objective of this study was to determine whether MSCs suppress hemorrhagic events after rtPA therapy in the acute phase of transient middle cerebral artery occlusion (tMCAO) in rats...
January 6, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28056813/hemodynamic-effects-of-intraoperative-anesthetics-administration-in-photothrombotic-stroke-model-a-study-using-laser-speckle-imaging
#19
Hongyang Lu, Yao Li, Bin Bo, Lu Yuan, Xiaodan Lu, Hangdao Li, Shanbao Tong
BACKGROUND: Previous neuroimaging studies have shown the hemodynamic effect of either preconditioning or postconditioning anesthesia in ischemic stroke model. However, the anesthetic effect in hemodynamics during and immediately after the stroke modeling surgery remains unknown due to the lack of appropriate anesthesia-free stroke model and intraoperative imaging technology. In the present study, we utilized our recently developed photothrombotic model of focal cerebral ischemia in conscious and freely moving rats, and investigated transient hemodynamic changes with or without isoflurane administration...
January 5, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28053820/effects-of-different-concurrent-resistance-and-aerobic-training-frequencies-on-muscle-power-and-muscle-quality-in-trained-elderly-men-a-randomized-clinical-trial
#20
Rodrigo Ferrari, Sandra C Fuchs, Luiz Fernando Martins Kruel, Eduardo Lusa Cadore, Cristine Lima Alberton, Ronei Silveira Pinto, Régis Radaelli, Maira Schoenell, Mikel Izquierdo, Hirofumi Tanaka, Daniel Umpierre
Muscle power is a strong predictor of functional status in the elderly population and is required to perform different daily activities. To compare the effects of different weekly training frequencies on muscle power and muscle quality induced by concurrent training (resistance + aerobic) in previously trained elderly men. Twenty-four trained elderly men (65 ± 4 years), previously engaged in a regular concurrent training program, three times per week, for the previous five months, were randomly allocated to concurrent training programs in which training was performed either twice a week (2·week(-1), n = 12) or three times per week (3·week(-1), n = 12)...
December 2016: Aging and Disease
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