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Postpartum myometritis/ endometritis

R Nadisauskiene, S Bergström
The purpose of this study was to elucidate whether the use of intravenous ampicillin (vs. placebo therapy) in women in early active-phase preterm labor reduces infectious complications postpartum in mothers and their newborns. A randomised, double-blind, placebo-controlled study was carried out on 102 women with gestational age < 37 completed weeks in the active phase of labor (dilatation of cervix > or = 4 cm). Enrolled women received a loading dose of 5 g of ampicillin (n = 44) or placebo (n = 58) in intravenous infusion twice, 4 h apart...
1996: Gynecologic and Obstetric Investigation
L Almeida, A Schmauch, S Bergström
One hundred and six third trimester pregnant women with prelabour rupture of membranes preterm were randomised to either peroral amoxicillin 0.75 g 3 times daily (n = 50) or placebo (n = 56) in a blinded way. The patients were hospitalised in bed for 7 days unless contractions started and delivery ensued. Only 1 patient was discharged after 7 days of treatment, while the remaining ones delivered within 1 week after admission. The average rupture-to-expulsion interval was 68.4 h in the placebo group and 91.7 h in the amoxicillin group, implying a significantly prolonged stay by 43% in the amoxicillin group (p = 0...
1996: Gynecologic and Obstetric Investigation
A Libombo, E Folgosa, S Bergström
Postpartum endometritis-myometritis (PPEM) was identified in 51 women after vaginal delivery, who were compared with 51 healthy referent parturients, matched for age, parity and days postpartum. Socio-economic background data, past and current obstetric history and clinical data from recent delivery were analyzed. Endocervical and intracavitary cultures and blood cultures were performed and serological analyses of syphilis and HIV antibodies were carried out. No socio-economic factor studied discriminated significantly between cases and referents...
1994: Gynecologic and Obstetric Investigation
R Azziz, J Cumming, R Naeye
Postoperative endomyometritis develops in as many as 85% of women undergoing cesarean section, which is 10- to 30-fold higher than after vaginal delivery. The timing and mechanism by which the infecting organisms gain access to the uterine cavity are unclear. One possibility is that the infection may occur postpartum by ascending colonization of the wound. Alternatively, myometritis may be already present at the time the cesarean section is performed in asymptomatic patients. With tissue necrosis, the stage is then set for puerperal endomyometritis...
November 1988: American Journal of Obstetrics and Gynecology
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