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Q Wang, N Ma, H Si, Y M Ma, N Li, Y G Nie, D Y Sun, Z Wang
Objective: To investigate the status of survival and related risk factors among HIV-exposed children in Henan province from 2002 to 2014. Methods: A follow-up program was set up when infants as 1, 3, 6, 9, 12, 18 month olds. Data regarding the HIV-exposed children and their mothers were collected, including service of PMTCT, antiviral therapy, incidence of infectious disease and survival status of infants. Univariate and multivariate logistic regression models were used to explore the risk factors. Results: A total number of 1 705 HIV-infected infants were reported from 2002 to 2014...
December 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
Jia Sun, Heling Chen, Yirui Xie, Junwei Su, Ying Huang, Lijun Xu, Michael Yin, Qihui Zhou, Biao Zhu
Background. The etiology of immune reconstitution inflammatory syndrome (IRIS) in AIDS patients after the initiation of HAART remains unknown. Several researches indicated that the development of IRIS is associated with the production and variation of cytokines, whose gene expression are closely related to the Ca2(+)/CN-nuclear factor of activated T cells (NFAT) pathway. Methods. We studied the expression of NFAT isoforms and their major target cytokines genes in peripheral blood CD3(+) T cells of subjects through fluorescence quantitative PCR and explored the expression changes of these genes before and after HAART...
2017: Mediators of Inflammation
Dingyong Sun, Wenjie Yang, Yanmin Ma, Qi Wang, Jia Liu, Panying Fan, Ning Li, Qian Zhu, Zhe Wang
OBJECTIVE: To analyze the survival status and influencing factors of the AIDS patients under 14 years of age and receiving antiretroviral treatment in Henan Province. METHODS: Database of children AIDS patients receiving ART were download from China information system for disease preventioin and control-AIDS, AIDS cases from January, 2003 to June, 2014 were selected to be analyzed. Demographic characteristics baseline laboratory inclusion criteria: F First time receive national free ART during study; aged 14 years or below; and with relatively complete baseline information and follow-up information...
August 2015: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
Bryant Nguyen, Michelle Fennessy, Ferdinand Leya, Wojciech Nowak, Michael Ryan, Sheldon Freeberg, Jasrai Gill, Robert S Dieter, Lowell Steen, Bruce Lewis, Mark Cichon, Beatrice Probst, Michael Jarotkiewicz, David Wilber, John J Lopez
BACKGROUND: Over the last decade, significant advances in ST-elevation myocardial infarction (STEMI) workflow have resulted in most hospitals reporting door-to-balloon (D2B) times within the 90 min standard. Few programs have been enacted to systematically attempt to achieve routine D2B within 60 min. We sought to determine whether 24-hr in-house catheterization laboratory coverage via an In-House Interventional Team Program (IHIT) could achieve D2B times below 60 min for STEMI and to compare the results to the standard primary percutaneous coronary intervention (PCI) approach...
August 2015: Catheterization and Cardiovascular Interventions
Geling Li, Robert D Lewis, Nidhi Mishra, Constantine A Axiotis
The impact of highly active anti-retroviral therapy (HAART) in multiple myeloma (MM) is unknown. Ten HIV+ and 28 HIV-negative patients were retrospectively identified out of 262 cases of MM diagnosed at Kings County Hospital Center since the introduction of HAART in 1996. The HIV+ MM patients on HAART had superior overall survival (OS) (Fisher exact, p=0.008; log-rank, p=0.012) and progression free survival (PFS) (Fisher exact, p=0.007; log-rank, p=0.009) than the HIV-negative MM patients. HAART alone blocked the production of serum M-protein...
September 2014: Leukemia Research
Takao Watanabe, Yoshio Tokumoto, Masashi Hirooka, Yohei Koizumi, Fujimasa Tada, Hironori Ochi, Masanori Abe, Teru Kumagi, Yoshio Ikeda, Bunzo Matsuura, Kiyonori Takada, Yoichi Hiasa
The present report describes a case of a patient with hepatitis B virus (HBV)-human immunodeficiency virus (HIV) co-infection who was treated with tenofovir disoproxil (TDF)-based highly active antiretroviral therapy (HAART) and who achieved HBs antigen (Ag)/antibody (Ab) seroconversion. An 18-year-old Japanese man with HIV and HBV co-infection presented to our hospital. His CD4 count was decreased, and TDF-based HARRT was started. At 30 months after initiation of therapy, HBsAg was not detected. At 36 months after initiation of therapy, HBsAb was detected...
2014: Internal Medicine
Li-juan Wu, Chang-zhong Jin, Shi Bai, Yong Liang, Nan-ping Wu
OBJECTIVE: To assess changes of liver function in HIV-positive children with/without HBV/ HCV co-infection after 1 year of highly active antiretroviral therapy (HARRT). METHODS: Seventy-eight pediatric AIDS patients with HBV/HCV co-infection,19 pediatric AIDS patients with HBV co-infection and 44 pediatric AIDS patients without HBV/HCV co-infection who received HAART at least for 1 year were enrolled. HIV-1 viral load was quantitatively detected using a standardized reverse transcriptase-polymerase chain reaction assay, and blood cells were determined by three-color flow cytometry...
March 2014: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
Gaoli Fang, Luo Zhang, Chengshuo Wang, Jiang Xiao, Qian Fu, Hongxin Zhao
OBJECTIVE: To understand the high incidence of pharyngeal ulcer in patients with acquired immune deficiency syndrome (AIDS). By analyzing the clinical features in AIDS patients with pharyngeal ulcer, this study provided reference for clinicians. METHODS: Twenty AIDS patients with pharyngeal ulcer were retrospectively analysed to explore its clinical features and mechanism, and to explore the feasible therapeutic methods. RESULTS: The patients generally had severe sore throat and dysphagia for 7 days to 8 months, resulting in significant weight loss...
February 2014: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
Wen-Fang Xu, Yong Wu, Guo-Shao Pan, Jian-Ping Zhong, Shao-Bo Lan, Xue-Fang Chen, Qiu-Qiong Lu
OBJECTIVE: To explore the effect of Qiling Decoction (QD) combined highly active antiretroviral treatment (HAART) on expression levels of peripheral blood Th17 and Treg cells in HIV/AIDS patients. METHODS: Totally 55 HIV/AIDS patients were randomly assigned to the treatment group (28 cases) and the combination group (27 cases). Besides, 21 HIV negative patients were recruited as the healthy control group. Those in the treatment group received HARRT alone, while those in the combination group received HAART combined QD...
February 2014: Chinese Journal of Integrated Traditional and Western Medicine
Sh Osiya, F Binesh, F Ferdosian, M Shakiba
BACKGROUND: Immune deficiency in human might be primary or secondary and could be seen with a wide variety of manifestations. In the following, we presented a Child with various complains that diagnosed to have HIV infection. CASE REPORT: A 2/5 y/o child was admitted to the hospital for FUO with prolonged cough, FTT, cervical lymphadenopathy, hepatosplenomegaly and bilateral optic neuritis. . He was hospitalized for fever, cytopenia and hepatosplenomegaly one year ago, and three months later in an outpatient visit, these signs improved, except thrombocytopenia...
2012: Iranian Journal of Pediatric Hematology and Oncology
Xiqian Lan, Kang Cheng, Nirupama Chandel, Rivka Lederman, Aakash Jhaveri, Mohammad Husain, Ashwani Malhotra, Pravin C Singhal
It is well known that patients with HIV are prone to diabetes mellitus because of the side effects of HARRT. However, whether high glucose affects the HIV infection of T cells is not clear. Recent studies have shown that upregulation of GLUT-1 renders T cells susceptible to HIV infection. We hypothesized that hyperglycemia has the potential to increase HIV infection by enhancing its entry into immune cells. The effect of high glucose on HIV entry into T cells (Jurkat cells and PBMCs) and the mechanisms involved were investigated...
October 2013: Journal of Leukocyte Biology
Li-fen Huang, Xiao-ping Tang, Wei-ping Cai, Chun-liang Lei, Fu-chun Zheng, Wei-lie Chen, Xiao-xin Ye
OBJECTIVE: To analyze the death causes of 345 cases with HIV/AIDS in Guangdong area. METHODS: The situations of 345 hospitalized death cases with HIV/AIDS were conducted by retrospective analysis. RESULTS: (1)There were total 3406 hospitalized cases with HIV/AIDS in a hospital from January 2001 to December 2011 and 345 cases died, the fatality rate was 10. 13%. Since 2005 the introduction of free anti-viral treatment, the fatality rate of HIV/AIDS declined...
February 2013: Chinese Journal of Experimental and Clinical Virology
Yu-Ye Li, Wen-Ying Chen, Xia Li, Hong-Bin Li, Hui-Qin Li, Li Wang, Li He, Xin-Ping Yang, Xi-Cheng Wang, Yun-Li Huang, Yong-Gang Yao
BACKGROUND: Oral Candida colonization and its relation with predisposing factors in HIV-infected patients have received wide concerns during recent decades. In this study, we investigated asymptomatic oral Candida carriage rate, species distribution and antifungal susceptibility of 604 HIV-infected patients and 851 healthy individuals in Kunming, Yunnan Province of China. METHODS: Mucosal swab sampling was taken from each subject and CHROMagar Candida agar medium and API 20C AUX system were used to identify yeast isolates...
2013: BMC Infectious Diseases
Umadevi Krishna Mohan Rao, Kannan Ranganathan, Nagalingeswaran Kumarasamy
INTRODUCTION: In India, it is estimated that 2.5 million people are currently living with Human Immunodeficiency virus infection (HIV) of which one million are women. Given the occurrence of oral lesions in our population, we studied the patter of these lesions with respect to the role played by gender. MATERIALS AND METHODS: 3729 consecutive patients seen over a period of 10 years (from 1998 to 2008) attending the YRG CARE (Center for AIDS Research and Education), at Chennai, India constituted the study group...
September 2012: Journal of Oral and Maxillofacial Pathology: JOMFP
Fei-Fei Guo, Guo-Min Chen, Yi Zeng
OBJECTIVE: To analyze the genome mutations of HIV-1 gag, pol and env genes from HIV-infected paid blood donors in rural central China. METHODS: DNA was extracted from peripheral blood mononuclear cells, gag (p17-p24), pol (PR-RT), env (C2-V5) genes were amplified by nested polymerase chain reaction (PCR), purified products were sequenced, and sequence data was analyzed by MEGA5.0 soft wares. RESULTS: Twenty-three samples were subtype B, two samples were recombinant of subtype B and subtype C, one sample was recombinant of subtype CRF01_AE and subtype B...
February 2012: Chinese Journal of Experimental and Clinical Virology
Y Traore, F Dicko Traore, I Teguete, N Mounkoro, A Thera, A Sissoko, A Diallo, T Dolo, M Bagayogo, Y M Djire, D Kone, D Doumbia, O Kone, L Tinfa, A Sofara, M Sylla, M Traore, A B Diop, O Diop, A Dolo
AIM: Pregnant women HIV infection has main risk the contamination of newborn. MTCT actions permit to reduce that risk. MATERIAL AND METHODS: Our survey has been realized in Gabriel Touré teaching hospital gynecology and obstetrics and pediatric departments. It is about an observational prospective and descriptive survey that spreads on a period from January 2005 to December 2008. Has been included in the study all the HIV positive pregnant women followed in our service and their babies that had received ARV prophylaxis and 18 months of life serology...
2011: Le Mali Médical
Go Kanzaki, Nobuo Tsuboi, Yoichi Miyazaki, Takashi Yokoo, Yasunori Utsunomiya, Tatsuo Hosoya
This report presents a human immunodeficiency virus (HIV) patient that developed a slowly progressive renal impairment over years under highly active antiretroviral therapy (HAART). The renal biopsy showed diffuse tubulointerstitial nephritis accompanied by crystal formations that were surrounded by multinuclear giant cells. Furthermore, rod-like crystals were detected in the urinary sediments. Tenofovir and Atazanavir were thought to be the causative drugs for the renal injury. Therefore, the possibility of HARRT-induced nephrotoxicity should be considered in HIV-infected patients, even though the activity of HIV is controlled by such therapies...
2012: Internal Medicine
Ding-yong Sun, Qi Wang, Wen-jie Yang, Qian Zhu, Zhe Wang
OBJECTIVE: To study the effect of a government-provided-free highly active antiretroviral treatment (HAART) program, on the reduction of mortality and relevant risk factors among adult (AIDS) patients in Henan province. METHODS: Data on the survival and deaths of AIDS patients were collected from the National HAART reporting system between 2003 and 2009. Cox proportional hazards model was applied to analyze those factors that affecting the survival time of the patients...
February 2012: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
Li Huang, Phong Ho, Jie Yu, Lei Zhu, Kuo-Hsiung Lee, Chin-Ho Chen
Highly active antiretroviral therapy (HAART) has offered a promising approach for controlling HIV-1 replication in infected individuals. However, with HARRT, HIV-1 is suppressed rather than eradicated due to persistence of HIV-1 in latent viral reservoirs. Thus, purging the virus from latent reservoirs is an important strategy toward eradicating HIV-1 infection. In this study, we discovered that the daphnane diterpene gnidimacrin, which was previously reported to have potent anti-cancer cell activity, activated HIV-1 replication and killed persistently-infected cells at picomolar concentrations...
2011: PloS One
Weijun Zhu, Yanmei Jiao, Rongyue Lei, Wei Hua, Rui Wang, Yunxia Ji, Zhiying Liu, Feili Wei, Tong Zhang, Xuanlin Shi, Hao Wu, Linqi Zhang
BACKGROUND: Despite prolonged treatment with highly active antiretroviral therapy (HAART), the infectious HIV-1 continues to replicate and resides latently in the resting memory CD4+ T lymphocytes, which blocks the eradication of HIV-1. The viral persistence of HIV-1 is mainly caused by its proviral DNA being either linear nonintegrated, circular nonintegrated, or integrated. Previous reports have largely focused on the dynamics of HIV-1 DNA from the samples collected with relatively long time intervals during the process of disease and HAART treatment, which may have missed the intricate changes during the intervals in early treatment...
2011: PloS One
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