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https://www.readbyqxmd.com/read/24595923/intranasal-submucosal-bevacizumab-for-epistaxis-in-hereditary-hemorrhagic-telangiectasia-a-double-blind-randomized-placebo-controlled-trial
#1
RANDOMIZED CONTROLLED TRIAL
Dominik Riss, Martin Burian, Axel Wolf, Veronika Kranebitter, Alexandra Kaider, Christoph Arnoldner
BACKGROUND: The purpose of this study was to investigate the efficacy of bevacizumab ("Avastin") for the treatment of epistaxis in hereditary hemorrhagic telangiectasia (HHT). METHODS: In this double blind, placebo controlled trial, 15 adult patients with HHT with a minimum of 2 epistaxis episodes per week were randomized. A history of thromboembolic events or recent or planned surgery led to exclusion. Patients received a single intranasal submucosal injection (10 mL) of 100 mg bevacizumab or placebo...
June 2015: Head & Neck
https://www.readbyqxmd.com/read/23164683/bevacizumab-as-rescue-treatment-for-severe-recurrent-gastrointestinal-bleeding-in-hereditary-hemorrhagic-telangiectasia
#2
Alexandru Lupu, Carmen Stefanescu, Xavier Treton, Alain Attar, Olivier Corcos, Yoram Bouhnik
Hereditary hemorrhagic telangiectasia (HHT) also known as Rendu Osler syndrome is a vascular hereditary autosomal dominant disease, leading to a dysfunction in the development of arteriovenous capillaries, usually resulting in epistaxis, gastrointestinal (GI) bleeding, and iron deficiency anemia. It is believed that by interfering and stopping angiogenesis, anti-vascular endothelial growth factor molecules could be an option for HHT patients. Indeed, an intranasal treatment regime of diluted Avastin (bevacizumab; recombinant humanized antivascular epithelial growth factor immunoglobin G1) has proven clinically efficacious in patients with HHT1...
March 2013: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/22565282/bevacizumab-in-hereditary-hemorrhagic-telangiectasia-associated-epistaxis-effectiveness-of-an-injection-protocol-based-on-the-vascular-anatomy-of-the-nose
#3
Sinan Dheyauldeen, Amy Østertun Geirdal, Terje Osnes, Liv Sofie Vartdal, Ralph Dollner
OBJECTIVE/HYPOTHESIS: To evaluate the effectiveness of a standardized intranasal bevacizumab injection in treating hereditary hemorrhagic telangiectasia (HHT)-associated epistaxis. STUDY DESIGN: Prospective pilot study. METHODS: A total dose of 100 mg bevacizumab (25 mg/mL Avastin) was injected submucosally, 50 mg on each side. A total of 0.5 mL was injected in the sphenopalatine area, upper part of bony septum, upper part of the later nasal wall, and the anterior part of nasal floor...
June 2012: Laryngoscope
https://www.readbyqxmd.com/read/22185482/individualized-therapy-of-hht-driven-by-network-analysis-of-metabolomic-profiles
#4
Neema Jamshidi, Franklin J Miller, Jess Mandel, Timothy Evans, Michael D Kuo
BACKGROUND: Hereditary Hemorrhagic Telangiectasia (HHT) is an autosomal dominant disease with a varying range of phenotypes involving abnormal vasculature primarily manifested as arteriovenous malformations in various organs, including the nose, brain, liver, and lungs. The varied presentation and involvement of different organ systems makes the choice of potential treatment medications difficult. RESULTS: A patient with a mixed-clinical presentation and presumed diagnosis of HHT, severe exertional dyspnea, and diffuse pulmonary shunting at the microscopic level presented for treatment...
2011: BMC Systems Biology
https://www.readbyqxmd.com/read/22129679/effects-of-dilution-and-prolonged-storage-with-preservative-in-a-polyethylene-container-on-bevacizumab-avastin%C3%A2-for-topical-delivery-as-a-nasal-spray-in-anti-hereditary-hemorrhagic-telangiectasia-and-related-therapies
#5
Simon Kaja, Jill D Hilgenberg, Eric Everett, Scott E Olitsky, Jim Gossage, Peter Koulen
BACKGROUND: Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant vascular dysplasia and severe, recurrent epistaxis is a common clinical phenotype associated with HHT. An intranasal treatment regime of diluted Avastin™ (Bevacizumab; recombinant humanized anti-vascular epithelial growth factor immunoglobin G1) using apulsatile nasal irrigator has proven efficacious in clinical practice. However, concerns regarding the stability of Avastin™ following dilution and prolonged storage in standard containers used for drug delivery, such as polyethylene bottles, have so far prevented a more widespread clinical use...
2011: Human Antibodies
https://www.readbyqxmd.com/read/21805356/a-retrospective-analysis-of-low-dose-intranasal-injected-bevacizumab-avastin-in-hereditary-haemorrhagic-telangiectasia
#6
C Rohrmeier, H G Sachs, T S Kuehnel
The constantly recurring epistaxis means a great reduction of quality of life for patients with hereditary haemorrhagic telangiectasia (HHT). As yet, an ideal treatment has not been found. Vascular endothelial growth factor (VEGF) has been described as a possible new therapy. In particular, the success of submucosal doses <100 mg has not been analysed before. We injected bevacizumab (Avastin) submucosally in addition to Nd:YAG laser therapy. Doses <7.5 mg were used. To investigate the effect of these additional injections in comparison to laser therapy alone, a retrospective analysis was done...
February 2012: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/21344447/safety-of-intranasal-bevacizumab-avastin-treatment-in-patients-with-hereditary-hemorrhagic-telangiectasia-associated-epistaxis
#7
Sonia Chen, Tom Karnezis, Terence M Davidson
OBJECTIVES/HYPOTHESIS: Assess for complications of intranasal Bevacizumab application in patients with hereditary hemorrhagic telangiectasia (HHT)-associated epistaxis. STUDY DESIGN: Retrospective chart review. METHODS: In 58 patients presenting with recurrent HHT epistaxis, Bevacizumab was applied intranasally either as a submucosal injection or as a topical spray between October 2006 and June 2010. In many of the injected patients, the potassium titanyl phosphate (KTP) laser was used adjunctively for vessel photocoagulation...
March 2011: Laryngoscope
https://www.readbyqxmd.com/read/21344445/efficacy-of-intranasal-bevacizumab-avastin-treatment-in-patients-with-hereditary-hemorrhagic-telangiectasia-associated-epistaxis
#8
Tom T Karnezis, Terence M Davidson
OBJECTIVES/ HYPOTHESIS: Intranasal Bevacizumab is an effective therapy for epistaxis in patients with hereditary hemorrhagic telangiectasia (HHT). STUDY DESIGN: Retrospective chart review. METHODS: In 32 successive patients presenting with recurrent HHT epistaxis 25-100 mg of Bevacizumab was applied intranasally either as a submucosal injection or as a topical spray between November 2008 and May 2010. In many of the injected patients, the Potassium Titanyl Phosphate (KTP) laser was used adjunctively for vessel photocoagulation...
March 2011: Laryngoscope
https://www.readbyqxmd.com/read/21165966/efficacy-of-intranasal-bevacizumab-avastin-treatment-in-patients-with-hereditary-hemorrhagic-telangiectasia-associated-epistaxis
#9
Tom T Karnezis, Terence M Davidson
OBJECTIVES/ HYPOTHESIS:: Intranasal Bevacizumab is an effective therapy for epistaxis in patients with hereditary hemorrhagic telangiectasia (HHT). STUDY DESIGN:: Retrospective chart review. METHODS:: In 32 successive patients presenting with recurrent HHT epistaxis 25-100 mg of Bevacizumab was applied intranasally either as a submucosal injection or as a topical spray between November 2008 and May 2010. In many of the injected patients, the Potassium Titanyl Phosphate (KTP) laser was used adjunctively for vessel photocoagulation...
December 16, 2010: Laryngoscope
https://www.readbyqxmd.com/read/21072846/safety-of-intranasal-bevacizumab-avastin-treatment-in-patients-with-hereditary-hemorrhagic-telangiectasia-associated-epistaxis
#10
Sonia Chen, Tom Karnezis, Terence M Davidson
OBJECTIVES/HYPOTHESIS:: Assess for complications of intranasal Bevacizumab application in patients with hereditary hemorrhagic telangiectasia (HHT)-associated epistaxis. STUDY DESIGN:: Retrospective chart review. METHODS:: In 58 patients presenting with recurrent HHT epistaxis, Bevacizumab was applied intranasally either as a submucosal injection or as a topical spray between October 2006 and June 2010. In many of the injected patients, the potassium titanyl phosphate (KTP) laser was used adjunctively for vessel photocoagulation...
November 11, 2010: Laryngoscope
https://www.readbyqxmd.com/read/19998344/hereditary-hemorrhagic-telangiectasia-avastin
#11
Terence M Davidson, Scott E Olitsky, Julie L Wei
This is the first scientific report of hereditary hemorrhagic telangiectasia (HHT) epistaxis treatment by intranasal spraying of the vascular endothelial growth factor (VEGF) inhibitor bevacizumab (Avastin). Epistaxis in patients with HHT is a morbid, mortal condition that is difficult and unpleasant to manage. Nasal telangiectasia growth is modulated by VEGF, which is elevated in HHT patients. Bevacizumab is a VEGF inhibitor that diminishes epistaxis when administered intravenously or injected locally, or as reported here when sprayed topically onto the nasal mucosa...
February 2010: Laryngoscope
https://www.readbyqxmd.com/read/19194865/the-effect-of-bevacizumab-avastin-treatment-on-epistaxis-in-hereditary-hemorrhagic-telangiectasia
#12
Jana Simonds, Frank Miller, Jess Mandel, Terence M Davidson
OBJECTIVES/HYPOTHESIS: Determine the effectiveness of treating epistaxis in hereditary hemorrhagic telangiectasia (HHT) with potassium titanyl phosphate (KTP) laser cautery combined with submucosal injection of 100 mg of bevacizumab. STUDY DESIGN: Retrospective pilot study. METHODS: Bevacizumab was injected throughout the nasal cavity following KTP laser treatment in 10 patients (bevacizumab/KTP group) and compared to nine patients previously treated with KTP laser alone (KTP group)...
May 2009: Laryngoscope
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