Josiane Mann, Eduard Reznik, Melania Santer, Mark A Fongheiser, Nailah Smith, Tal Hirschhorn, Fereshteh Zandkarimi, Rajesh Kumar Soni, Alcir Luiz Dafré, Antonio Miranda-Vizuete, Marcelo Farina, Brent R Stockwell
Iron overload, characterized by accumulation of iron in tissues, induces a multiorgan toxicity whose mechanisms are not fully understood. Using cultured cell lines, Caenorhabditis elegans, and mice, we found that ferroptosis occurs in the context of iron-overload-mediated damage. Exogenous oleic acid protected against iron-overload-toxicity in cell culture and Caenorhabditis elegans by suppressing ferroptosis. In mice, oleic acid protected against FAC-induced liver lipid peroxidation and damage. Oleic acid changed the cellular lipid composition, characterized by decreased levels of polyunsaturated fatty acyl phospholipids and decreased levels of ether-linked phospholipids...
November 1, 2023: Cell Chemical Biology