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tissue and organ homologues

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https://www.readbyqxmd.com/read/29017941/novel-ifn%C3%AE-homologue-identified-in-nile-tilapia-oreochromis-niloticus-links-with-immune-response-in-gills-under-different-stimuli
#1
Janet Velázquez, Jannel Acosta, Naylin Herrera, Antonio Morales, Osmany González, Fidel Herrera, Mario Pablo Estrada, Yamila Carpio
Interferon gamma (IFN-γ) has important roles in both innate and adaptive immune responses. This cytokine plays a very important role in defining Th1 immune response in all vertebrates. In the present study, we identified and isolated for the first time the gene coding for Nile tilapia (Oreochromis niloticus) IFNγ from spleen lymphocytes. The isolated tilapia IFNγ has between 23 and 62% of amino acid identity as compared to reported sequences for other teleost fishes. It has close phylogenetic relationships with IFNγ molecules belonging to the group of Perciforms and presents the typical structural characteristics of gamma interferon molecules...
October 7, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28982315/bacterial-protein-mimetic-of-peptide-hormone-as-a-new-class-of-protein-based-drugs
#2
S O Fetissov, Romain Legrand, Nicolas Lucas
Background Specific peptide molecules classified as hormones, neuropeptides and cytokines are involved in intercellular signaling regulating various physiological processes in all organs and tissues. This justifies the peptidergic signaling as an attractive pharmacological target. Recently, a protein mimetic of a peptide hormone has been identified in Escherichia coli suggesting the potential use of specific bacterial proteins as a new type of peptide-like drugs. Objective This paper describes the scientific rational and the technological approach leading to the identification of the E...
October 5, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28973578/identification-and-characterization-of-bmvta1-a-bombyx-mori-lepidoptera-bombycidae-homologue-for-vta1-that-is-up-regulated-in-development
#3
Hengchuan Xia, Dandan Shao, Xiaoyong Liu, Qiang Wang, Yang Zhou, Keping Chen
Vps20-associated 1 (Vta1) positively regulates Vacuolar protein sorting 4 (Vps4) to disassemble endosomal sorting complex required for transport III (ESCRT-III) for repeated uses in multivesicular body (MVB) pathway, virus budding and other processes. Currently, these proteins have mainly been studied in yeast and mammalian cells, while identities of them in insects remain largely unknown. We previously identified BmVps4, a Vps4 homologue from Bombyx mori. Here, we report the identification of a homologue for Vta1, designated as BmVta1...
May 1, 2017: Journal of Insect Science
https://www.readbyqxmd.com/read/28955749/structure-organization-and-tissue-expression-of-the-pig-slc13a1-and-slc13a4-sulfate-transporter-genes
#4
Samuel K Barnes, Yvonne A Eiby, Soohyun Lee, Barbara E Lingwood, Paul A Dawson
Sulfate is an obligate nutrient for fetal growth and development. In mice, the renal Slc13a1 sulfate transporter maintains high maternal circulating levels of sulfate in pregnancy, and the placental Slc13a4 sulfate transporter mediates sulfate supply to the fetus. Both of these genes have been linked to severe embryonal defects and fetal loss in mice. However, the clinical significance of SLC13A1 and SLC13A4 in human gestation is unknown. One approach towards understanding the potential involvement of these genes in human fetal pathologies is to use an animal model, such as the pig, which mimics the developmental trajectory of the human fetus more closely than the previously studied mouse models...
July 2017: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28947654/when-the-lyon-ized-chromosome-roars-ongoing-expression-from-an-inactive-x-chromosome
#5
REVIEW
Laura Carrel, Carolyn J Brown
A tribute to Mary Lyon was held in October 2016. Many remarked about Lyon's foresight regarding many intricacies of the X-chromosome inactivation process. One such example is that a year after her original 1961 hypothesis she proposed that genes with Y homologues should escape from X inactivation to achieve dosage compensation between males and females. Fifty-five years later we have learned many details about these escapees that we attempt to summarize in this review, with a particular focus on recent findings...
November 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28820389/hippo-pathway-brief-overview-of-its-relevance-in-cancer
#6
A L Zygulska, K Krzemieniecki, P Pierzchalski
The Hippo pathway is the major regulator of organ growth and proliferation. Described initially in Drosophila, it is now recognized as one of the most conserved molecular pathways in all metazoan. Recent studies have revealed the Hippo signalling pathway might contribute to tumorigenesis and cancer development. The core components of the Hippo pathway include the mammalian sterile 20-like kinases (MSTs), large tumour suppressor kinases (LATSs), the adaptor proteins Salvador homologue 1 (SAV1, also called WW45) and Mps One Binder kinase activator proteins...
June 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28724905/flowering-time-in-banana-musa-spp-a-day-neutral-plant-is-controlled-by-at-least-three-flowering-locus-t-homologues
#7
Akhilesh K Chaurasia, Hemant B Patil, Bal Krishna, V R Subramaniam, Prafullachandra V Sane, Aniruddha P Sane
Banana is an important day neutral food crop with a long flowering/fruiting cycle that is affected by hot summers or cold winters in different places. Manipulating its life cycle requires an understanding of its flowering time machinery to bypass these stresses. Twelve FLOWERING LOCUS T (FT) and two TWIN SISTER OF FT (TSF) members were isolated from banana and their organization and expression pattern studied during development in two varieties that differ in flowering time namely Grand Nain (AAA genotype) and Hill banana (AAB genotype)...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28666954/1700012b09rik-a-foxj1-effector-gene-active-in-ciliated-tissues-of-the-mouse-but-not-essential-for-motile-ciliogenesis
#8
Michael Stauber, Karsten Boldt, Christoph Wrede, Marina Weidemann, Manuela Kellner, Karin Schuster-Gossler, Mark Philipp Kühnel, Jan Hegermann, Marius Ueffing, Achim Gossler
In humans and mice, motile cilia occur on the surface of the embryonic ventral node, on respiratory and ependymal epithelia and in reproductive organs where they ensure normal left-right asymmetry of the organism, mucociliary clearance of airways, homeostasis of the cerebrospinal fluid and fertility. The genetic programme for the formation of motile cilia, thus critical for normal development and health, is switched on by the key transcription factor FOXJ1. In previous microarray screens for murine FOXJ1 effectors, we identified candidates for novel factors involved in motile ciliogenesis, including both genes that are well conserved throughout metazoa and beyond, like FOXJ1 itself, and genes without overt homologues outside higher vertebrates...
September 1, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28665270/meru-couples-planar-cell-polarity-with-apical-basal-polarity-during-asymmetric-cell-division
#9
Jennifer J Banerjee, Birgit L Aerne, Maxine V Holder, Simon Hauri, Matthias Gstaiger, Nicolas Tapon
Polarity is a shared feature of most cells. In epithelia, apical-basal polarity often coexists, and sometimes intersects with planar cell polarity (PCP), which orients cells in the epithelial plane. From a limited set of core building blocks (e.g. the Par complexes for apical-basal polarity and the Frizzled/Dishevelled complex for PCP), a diverse array of polarized cells and tissues are generated. This suggests the existence of little-studied tissue-specific factors that rewire the core polarity modules to the appropriate conformation...
June 30, 2017: ELife
https://www.readbyqxmd.com/read/28647817/molecular-characterization-of-the-cd79a-and-cd79b-and-its-role-against-aeromonas-hydrophila-infection-in-chinese-sucker-myxocyprinus-asiaticus
#10
Huan Li, Yujin Li, Xiaoping Zhang, Yafeng Wang, Wufeng Zhang, Xia Wu, Zhijian Wang
CD79a and CD79b heterodimers are the important signaling components of B cell receptor (BCR) complex which plays a crucial role in B cell development and antibody production. In the present study, CD79a and CD79b homologues from Chinese sucker (Myxocyprinus asiaticus), namely MaCD79a and MaCD79b, were identified and their expression at early developmental stages and under constitutive and stimulated conditions were investigated. The cDNA sequences for MaCD79a and MaCD79b contained open reading frame of 678 and 636 bp in length for 225 and 211 amino acid residues, respectively...
December 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28607409/functional-characterization-of-aquaporin-like-genes-in-the-human-bed-bug-cimex-lectularius
#11
Hitoshi Tsujimoto, Joyce M Sakamoto, Jason L Rasgon
The bed bug Cimex lectularius is a blood-feeding re-emerging annoyance pest insect that has the ability to transmit Trypanosoma cruzi under experimental laboratory conditions. Aquaporins (AQPs) are water channel proteins that are essential in biological organisms. C. lectularius are constantly exposed to water-related stress, suggesting that AQPs may offer novel control avenues. We identified and cloned four AQPs from C. lectularius, assessed tissue and lifestage-specific expression, and characterized biochemical functions in vitro and in vivo...
June 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28581477/inter-organ-signalling-by-hrg-7-promotes-systemic-haem-homeostasis
#12
Jason Sinclair, Katherine Pinter, Tamika Samuel, Simon Beardsley, Xiaojing Yuan, Jianbing Zhang, Kevin Meng, Sijung Yun, Michael Krause, Iqbal Hamza
Growing evidence in vertebrates predicts that cellular haem levels in animals are maintained not only by a cell's internal capacity for haem synthesis in a cell-autonomous manner, but also by an inter-organ haem trafficking network through cell-non-autonomous regulation. Using Caenorhabditis elegans, a genetically and optically amenable animal model for visualizing haem-dependent signalling, we show that HRG-7, a protein with homology to aspartic proteases, mediates inter-organ signalling between the intestine and extra-intestinal tissues...
July 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28579525/evolutionary-conserved-mechanisms-pervade-structure-and-transcriptional-modulation-of-allograft-inflammatory-factor-1-from-sea-anemone-anemonia-viridis
#13
Angela Cuttitta, Maria Antonietta Ragusa, Salvatore Costa, Carmelo Bennici, Paolo Colombo, Salvatore Mazzola, Fabrizio Gianguzza, Aldo Nicosia
Gene family encoding allograft inflammatory factor-1 (AIF-1) is well conserved among organisms; however, there is limited knowledge in lower organisms. In this study, the first AIF-1 homologue from cnidarians was identified and characterised in the sea anemone Anemonia viridis. The full-length cDNA of AvAIF-1 was of 913 bp with a 5' -untranslated region (UTR) of 148 bp, a 3'-UTR of 315 and an open reading frame (ORF) of 450 bp encoding a polypeptide with149 amino acid residues and predicted molecular weight of about 17 kDa...
August 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28576740/draft-genome-sequence-of-a-kluyvera-intermedia-isolate-from-a-patient-with-a-pancreatic-abscess
#14
Roland Thele, Heidi Gumpert, Louise B Christensen, Peder Worning, Kristian Schønning, Henrik Westh, Thomas A Hansen
The genus Kluyvera comprises potential pathogens that can cause many infections. This study reports a Kluyvera intermedia strain (FOSA7093) from a pancreatic cyst specimen from a long-term hospitalised patient. Whole-genome sequencing (WGS) of the K. intermedia isolate was performed and the strain was reported as sensitive to Danish-registered antibiotics although it had a fosA-like gene in the genome. There were nine contigs that aligned to a plasmid, and these contigs contained several heavy metal resistance gene homologues...
September 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28363992/mtlax2-a-functional-homologue-of-the-arabidopsis-auxin-influx-transporter-aux1-is-required-for-nodule-organogenesis
#15
Sonali Roy, Fran Robson, Jodi Lilley, Cheng-Wu Liu, Xiaofei Cheng, Jiangqi Wen, Simon Walker, Jongho Sun, Donna Cousins, Caitlin Bone, Malcolm J Bennett, J Allan Downie, Ranjan Swarup, Giles Oldroyd, Jeremy D Murray
Most legume plants can form nodules, specialized lateral organs that form on roots, and house nitrogen-fixing bacteria collectively called rhizobia. The uptake of the phytohormone auxin into cells is known to be crucial for development of lateral roots. To test the role of auxin influx in nodulation we used the auxin influx inhibitors 1-naphthoxyacetic acid (1-NOA) and 2-NOA, which we found reduced nodulation of Medicago truncatula. This suggested the possible involvement of the AUX/LAX family of auxin influx transporters in nodulation...
May 2017: Plant Physiology
https://www.readbyqxmd.com/read/28254500/molecular-characterization-and-expression-analysis-during-embryo-development-of-cd4-1-homologue-in-large-yellow-croaker-larimichthys-crocea
#16
Kaiqiong Mao, Wei Chen, Yinnan Mu, Jingqun Ao, Xinhua Chen
CD4(+) helper T (Th) cells are a master component of the adaptive immune response. CD4 is one of the most effective surface markers for identifying Th cells. In the present study, we cloned and characterized a CD4-1 homologue, LycCD4-1, from large yellow croaker Larimichthys crocea. The full-length cDNA of LycCD4-1 is 1695 bp long, encoding a protein of 462 amino acids. The deduced LycCD4-1 protein has a typical domain architecture as found in mammalian CD4 molecules, including a signal peptide, four extracellular immunoglobulin-like (Ig-like) domains, a transmembrane region, and a CXC signaling motif in the cytoplasmic tail...
May 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28231393/effects-of-tissue-culture-and-mycorrhiza-applications-in-organic-farming-on-concentrations-of-phytochemicals-and-antioxidant-capacities-in-ginger-zingiber-officinale-roscoe-rhizomes-and-leaves
#17
Byungrok R Min, Lurline E Marsh, Keegan Brathwaite, Adebola O Daramola
Tissue culture and mycorrhiza applications can provide disease-free seedlings and enhanced nutrient absorption, respectively, for organic farming. Ginger (Zingiber officinale Roscoe) is rich in phytochemicals and has various health-protective potentials. This study was aimed at determining effects of tissue culture and mycorrhiza applications alone or in combinations in organic farming on phytochemical contents (total phenolics and flavonoids [TP and TF, respectively], gingerol and shogaol homologues, phenolic acids, and carotenoids) and antioxidant capacities (DPPH [2,2-diphenyl-1-picrylhydrazyl] radical scavenging, oxygen radical absorbance (ORAC), and iron-chelating capacities [ICC]) in solvent-extractable (Free) and cell-wall-matrix-bound (Bound) fractions of ginger rhizome and Free fraction of the leaves in comparison with non-organics...
April 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28210849/developmental-changes-in-notch1-and-nle1-expression-in-a-genetic-model-of-absence-epilepsy
#18
Fariba Karimzadeh, Sayed Mostafa Modarres Mousavi, Fatemeh Alipour, Hassan Hosseini Ravandi, Stjepana Kovac, Ali Gorji
Childhood absence epilepsy (CAE) is an epilepsy syndrome with seizures occurring in the early childhood, highlighting that seizures susceptibility in CAE is dependent on brain development. The Notch 1 signalling pathway is important in brain development, yet the role of the Notch1 signalling pathway in CAE remains elusive. We here explored Notch1 and its modulator notchless homologue 1 (NLE1) expression in WAG/Rij and control rats using immunohistochemistry. Functional Notch 1 effects were assessed in WAG/Rij rats in vivo...
February 16, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28201995/zoonotic-necrotizing-myositis-caused-by-streptococcus-equi-subsp-zooepidemicus-in-a-farmer
#19
Bård Reiakvam Kittang, Veronika Kuchařová Pettersen, Oddvar Oppegaard, Dag Harald Skutlaberg, Håvard Dale, Harald G Wiker, Steinar Skrede
BACKGROUND: Streptococcus equi subsp. zooepidemicus is a beta-hemolytic group C streptococcus mainly causing infections in domesticated animals. Here we describe the first case of zoonotic necrotizing myositis caused by this bacterium. CASE PRESENTATION: The patient was a 73-year-old, previously healthy farmer with two asymptomatic Shetland ponies in his stable. After close contact with the ponies while feeding them, he rapidly developed erythema of his left thigh and sepsis with multiple organ failure...
February 15, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28188746/context-dependent-epigenetic-regulation-of-nuclear-factor-of-activated-t-cells-1-in-pancreatic-plasticity
#20
Nai-Ming Chen, Albrecht Neesse, Moritz Lino Dyck, Benjamin Steuber, Alexander O Koenig, Clara Lubeseder-Martellato, Thore Winter, Teresa Forster, Hanibal Bohnenberger, Julia Kitz, Kirsten Reuter-Jessen, Heidi Griesmann, Jochen Gaedcke, Marian Grade, Jin-San Zhang, Wan-Chi Tsai, Jens Siveke, Hans-Ulrich Schildhaus, Philipp Ströbel, Steven A Johnsen, Volker Ellenrieder, Elisabeth Hessmann
BACKGROUND & AIMS: The ability of exocrine pancreatic cells to change the cellular phenotype is required for tissue regeneration upon injury, but also contributes to their malignant transformation and tumor progression. We investigated context-dependent signaling and transcription mechanisms that determine pancreatic cell fate decisions toward regeneration and malignancy. In particular, we studied the function and regulation of the inflammatory transcription factor nuclear factor of activated T cells 1 (NFATC1) in pancreatic cell plasticity and tissue adaptation...
May 2017: Gastroenterology
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