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tissue and organ homologues

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https://www.readbyqxmd.com/read/28647817/molecular-characterization-of-the-cd79a-and-cd79b-and-its-role-against-aeromonas-hydrophila-infection-in-chinese-sucker-myxocyprinus-asiaticus
#1
Huan Li, Yujin Li, Xiaoping Zhang, Yafeng Wang, Wufeng Zhang, Xia Wu, Zhijian Wang
CD79a and CD79b heterodimers are the important signaling components of B cell receptor (BCR) complex which plays a crucial role in B cell development and antibody production. In the present study, CD79a and CD79b homologues from Chinese sucker (Myxocyprinus asiaticus), namely MaCD79a and MaCD79b, were identified and their expression at early developmental stages and under constitutive and stimulated conditions were investigated. The cDNA sequences for MaCD79a and MaCD79b contained open reading frame of 678 and 636 bp in length for 225 and 211 amino acid residues, respectively...
June 25, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28607409/functional-characterization-of-aquaporin-like-genes-in-the-human-bed-bug-cimex-lectularius
#2
Hitoshi Tsujimoto, Joyce M Sakamoto, Jason L Rasgon
The bed bug Cimex lectularius is a blood-feeding re-emerging annoyance pest insect that has the ability to transmit Trypanosoma cruzi under experimental laboratory conditions. Aquaporins (AQPs) are water channel proteins that are essential in biological organisms. C. lectularius are constantly exposed to water-related stress, suggesting that AQPs may offer novel control avenues. We identified and cloned four AQPs from C. lectularius, assessed tissue and lifestage-specific expression, and characterized biochemical functions in vitro and in vivo...
June 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28581477/inter-organ-signalling-by-hrg-7-promotes-systemic-haem-homeostasis
#3
Jason Sinclair, Katherine Pinter, Tamika Samuel, Simon Beardsley, Xiaojing Yuan, Jianbing Zhang, Kevin Meng, Sijung Yun, Michael Krause, Iqbal Hamza
Growing evidence in vertebrates predicts that cellular haem levels in animals are maintained not only by a cell's internal capacity for haem synthesis in a cell-autonomous manner, but also by an inter-organ haem trafficking network through cell-non-autonomous regulation. Using Caenorhabditis elegans, a genetically and optically amenable animal model for visualizing haem-dependent signalling, we show that HRG-7, a protein with homology to aspartic proteases, mediates inter-organ signalling between the intestine and extra-intestinal tissues...
June 5, 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28579525/evolutionary-conserved-mechanisms-pervade-structure-and-transcriptional-modulation-of-allograft-inflammatory-factor-1-from-sea-anemone-anemonia-viridis
#4
Angela Cuttitta, Maria Antonietta Ragusa, Salvatore Costa, Carmelo Bennici, Paolo Colombo, Salvatore Mazzola, Fabrizio Gianguzza, Aldo Nicosia
Gene family encoding allograft inflammatory factor-1 (AIF-1) is well conserved among organisms; however, there is limited knowledge in lower organisms. In this study, the first AIF-1 homologue from cnidarians was identified and characterised in the sea anemone Anemonia viridis. The full-length cDNA of AvAIF-1 was of 913 bp with a 5' -untranslated region (UTR) of 148 bp, a 3'-UTR of 315 and an open reading frame (ORF) of 450 bp encoding a polypeptide with149 amino acid residues and predicted molecular weight of about 17 kDa...
June 1, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28576740/draft-genome-sequence-of-a-kluyvera-intermedia-isolate-from-a-patient-with-a-pancreatic-abscess
#5
Roland Thele, Heidi Gumpert, Louise B Christensen, Peder Worning, Kristian Schønning, Henrik Westh, Thomas A Hansen
The genus Kluyvera comprises potential pathogens that can cause many infections. This study reports a Kluyvera intermedia strain (FOSA7093) from a pancreatic cyst specimen from a long-term hospitalised patient. Whole-genome sequencing (WGS) of the K. intermedia isolate was performed and the strain was reported as sensitive to Danish-registered antibiotics although it had a fosA-like gene in the genome. There were nine contigs that aligned to a plasmid, and these contigs contained several heavy metal resistance gene homologues...
May 30, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28363992/mtlax2-a-functional-homologue-of-the-arabidopsis-auxin-influx-transporter-aux1-is-required-for-nodule-organogenesis
#6
Sonali Roy, Fran Robson, Jodi Lilley, Cheng-Wu Liu, Xiaofei Cheng, Jiangqi Wen, Simon Walker, Jongho Sun, Donna Cousins, Caitlin Bone, Malcolm J Bennett, J Allan Downie, Ranjan Swarup, Giles Oldroyd, Jeremy D Murray
Most legume plants can form nodules, specialized lateral organs that form on roots, and house nitrogen-fixing bacteria collectively called rhizobia. The uptake of the phytohormone auxin into cells is known to be crucial for development of lateral roots. To test the role of auxin influx in nodulation we used the auxin influx inhibitors 1-naphthoxyacetic acid (1-NOA) and 2-NOA, which we found reduced nodulation of Medicago truncatula. This suggested the possible involvement of the AUX/LAX family of auxin influx transporters in nodulation...
May 2017: Plant Physiology
https://www.readbyqxmd.com/read/28254500/molecular-characterization-and-expression-analysis-during-embryo-development-of-cd4-1-homologue-in-large-yellow-croaker-larimichthys-crocea
#7
Kaiqiong Mao, Wei Chen, Yinnan Mu, Jingqun Ao, Xinhua Chen
CD4(+) helper T (Th) cells are a master component of the adaptive immune response. CD4 is one of the most effective surface markers for identifying Th cells. In the present study, we cloned and characterized a CD4-1 homologue, LycCD4-1, from large yellow croaker Larimichthys crocea. The full-length cDNA of LycCD4-1 is 1695 bp long, encoding a protein of 462 amino acids. The deduced LycCD4-1 protein has a typical domain architecture as found in mammalian CD4 molecules, including a signal peptide, four extracellular immunoglobulin-like (Ig-like) domains, a transmembrane region, and a CXC signaling motif in the cytoplasmic tail...
May 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28231393/effects-of-tissue-culture-and-mycorrhiza-applications-in-organic-farming-on-concentrations-of-phytochemicals-and-antioxidant-capacities-in-ginger-zingiber-officinale-roscoe-rhizomes-and-leaves
#8
Byungrok R Min, Lurline E Marsh, Keegan Brathwaite, Adebola O Daramola
Tissue culture and mycorrhiza applications can provide disease-free seedlings and enhanced nutrient absorption, respectively, for organic farming. Ginger (Zingiber officinale Roscoe) is rich in phytochemicals and has various health-protective potentials. This study was aimed at determining effects of tissue culture and mycorrhiza applications alone or in combinations in organic farming on phytochemical contents (total phenolics and flavonoids [TP and TF, respectively], gingerol and shogaol homologues, phenolic acids, and carotenoids) and antioxidant capacities (DPPH [2,2-diphenyl-1-picrylhydrazyl] radical scavenging, oxygen radical absorbance (ORAC), and iron-chelating capacities [ICC]) in solvent-extractable (Free) and cell-wall-matrix-bound (Bound) fractions of ginger rhizome and Free fraction of the leaves in comparison with non-organics...
April 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28210849/developmental-changes-in-notch1-and-nle1-expression-in-a-genetic-model-of-absence-epilepsy
#9
Fariba Karimzadeh, Sayed Mostafa Modarres Mousavi, Fatemeh Alipour, Hassan Hosseini Ravandi, Stjepana Kovac, Ali Gorji
Childhood absence epilepsy (CAE) is an epilepsy syndrome with seizures occurring in the early childhood, highlighting that seizures susceptibility in CAE is dependent on brain development. The Notch 1 signalling pathway is important in brain development, yet the role of the Notch1 signalling pathway in CAE remains elusive. We here explored Notch1 and its modulator notchless homologue 1 (NLE1) expression in WAG/Rij and control rats using immunohistochemistry. Functional Notch 1 effects were assessed in WAG/Rij rats in vivo...
February 16, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28201995/zoonotic-necrotizing-myositis-caused-by-streptococcus-equi-subsp-zooepidemicus-in-a-farmer
#10
Bård Reiakvam Kittang, Veronika Kuchařová Pettersen, Oddvar Oppegaard, Dag Harald Skutlaberg, Håvard Dale, Harald G Wiker, Steinar Skrede
BACKGROUND: Streptococcus equi subsp. zooepidemicus is a beta-hemolytic group C streptococcus mainly causing infections in domesticated animals. Here we describe the first case of zoonotic necrotizing myositis caused by this bacterium. CASE PRESENTATION: The patient was a 73-year-old, previously healthy farmer with two asymptomatic Shetland ponies in his stable. After close contact with the ponies while feeding them, he rapidly developed erythema of his left thigh and sepsis with multiple organ failure...
February 15, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28188746/context-dependent-epigenetic-regulation-of-nuclear-factor-of-activated-t-cells-1-in-pancreatic-plasticity
#11
Nai-Ming Chen, Albrecht Neesse, Moritz Lino Dyck, Benjamin Steuber, Alexander O Koenig, Clara Lubeseder-Martellato, Thore Winter, Teresa Forster, Hanibal Bohnenberger, Julia Kitz, Kirsten-Reuter Jessen, Heidi Griesmann, Jochen Gaedcke, Marian Grade, Jin-San Zhang, Wan-Chi Tsai, Jens Siveke, Hans-Ulrich Schildhaus, Philipp Ströbel, Steven A Johnsen, Volker Ellenrieder, Elisabeth Hessmann
BACKGROUND & AIMS: The ability of exocrine pancreatic cells to change the cellular phenotype is required for tissue regeneration upon injury, but also contributes to their malignant transformation and tumor progression. We investigated context-dependent signaling and transcription mechanisms that determine pancreatic cell fate decisions toward regeneration and malignancy. In particular, we studied the function and regulation of the inflammatory transcription factor nuclear factor of activated T cells 1 (NFATC1) in pancreatic cell plasticity and tissue adaptation...
February 8, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28174623/expression-patterns-of-passiflora-edulis-apetala1-fruitfull-homologues-shed-light-onto-tendril-and-corona-identities
#12
Livia C T Scorza, Jose Hernandes-Lopes, Gladys F A Melo-de-Pinna, Marcelo C Dornelas
BACKGROUND: Passiflora (passionflowers) makes an excellent model for studying plant evolutionary development. They are mostly perennial climbers that display axillary tendrils, which are believed to be modifications of the inflorescence. Passionflowers are also recognized by their unique flower features, such as the extra whorls of floral organs composed of corona filaments and membranes enclosing the nectary. Although some work on Passiflora organ ontogeny has been done, the developmental identity of both Passiflora tendrils and the corona is still controversial...
2017: EvoDevo
https://www.readbyqxmd.com/read/28124980/evolutionary-conservation-of-pou5f3-genomic-organization-and-its-dynamic-distribution-during-embryogenesis-and-in-adult-gonads-in-japanese-flounder-paralichthys-olivaceus
#13
Jinning Gao, Xubo Wang, Quanqi Zhang
Octamer-binding transcription factor 4 (Oct4) is a member of POU (Pit-Oct-Unc) transcription factor family Class V that plays a crucial role in maintaining the pluripotency and self-renewal of stem cells. Though it has been deeply investigated in mammals, its lower vertebrate homologue, especially in the marine fish, is poorly studied. In this study, we isolated the full-length sequence of Paralichthys olivaceus pou5f3 (Popou5f3), and we found that it is homologous to mammalian Oct4. We identified two transcript variants with different lengths of 3'-untranslated regions (UTRs) generated by alternative polyadenylation (APA)...
January 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28095410/cardiomyocyte-regulation-of-systemic-lipid-metabolism-by-the-apolipoprotein-b-containing-lipoproteins-in-drosophila
#14
Sunji Lee, Hong Bao, Zachary Ishikawa, Weidong Wang, Hui-Ying Lim
The heart has emerged as an important organ in the regulation of systemic lipid homeostasis; however, the underlying mechanism remains poorly understood. Here, we show that Drosophila cardiomyocytes regulate systemic lipid metabolism by producing apolipoprotein B-containing lipoproteins (apoB-lipoproteins), essential lipid carriers that are so far known to be generated only in the fat body. In a Drosophila genetic screen, we discovered that when haplo-insufficient, microsomal triglyceride transfer protein (mtp), required for the biosynthesis of apoB-lipoproteins, suppressed the development of diet-induced obesity...
January 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28077262/virus-innexins-induce-alterations-in-insect-cell-and-tissue-function
#15
Daniel K Hasegawa, Stephanie L Erickson, Bradley M Hersh, Matthew W Turnbull
Polydnaviruses are dsDNA viruses that induce immune and developmental alterations in their caterpillar hosts. Characterization of polydnavirus gene families and family members is necessary to understand mechanisms of pathology and evolution of these viruses, and may aid to elucidate the role of host homologues if present. For example, the polydnavirus vinnexin gene family encodes homologues of insect gap junction genes (innexins) that are expressed in host immune cells (hemocytes). While the roles of Innexin proteins and gap junctions in insect immunity are largely unclear, we previously demonstrated that Vinnexins form functional gap junctions and alter the junctional characteristics of a host Innexin when co-expressed in paired Xenopus oocytes...
January 7, 2017: Journal of Insect Physiology
https://www.readbyqxmd.com/read/27966893/enhancing-pet-signal-at-target-tissue-in-vivo-dendritic-and-multimeric-tris-hydroxypyridinone-conjugates-for-molecular-imaging-of-%C3%AE-v%C3%AE-3-integrin-expression-with-gallium-68
#16
Cinzia Imberti, Samantha Y A Terry, Carleen Cullinane, Fiona Clarke, Georgina H Cornish, Nisha K Ramakrishnan, Peter Roselt, Andrew P Cope, Rodney J Hicks, Philip J Blower, Michelle T Ma
Tris(hydroxypyridinone) chelators conjugated to peptides can rapidly complex the positron-emitting isotope gallium-68 ((68)Ga) under mild conditions, and the resulting radiotracers can delineate peptide receptor expression at sites of diseased tissue in vivo. We have synthesized a dendritic bifunctional chelator containing nine 1,6-dimethyl-3-hydroxypyridin-4-one groups (SCN-HP9) that can coordinate up to three Ga(3+) ions. This derivative has been conjugated to a trimeric peptide (RGD3) containing three peptide groups that target the αvβ3 integrin receptor...
February 15, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/27927697/absence-of-11-keto-reduction-of-cortisone-and-11-ketotestosterone-in-the-model-organism-zebrafish
#17
Maria Tsachaki, Arne Meyer, Benjamin Weger, Denise V Kratschmar, Janina Tokarz, Jerzy Adamski, Heinz-Georg Belting, Markus Affolter, Thomas Dickmeis, Alex Odermatt
Zebrafish are widely used as model organism. Their suitability for endocrine studies, drug screening and toxicity assessements depends on the extent of conservation of specific genes and biochemical pathways between zebrafish and human. Glucocorticoids consist of inactive 11-keto (cortisone and 11-dehydrocorticosterone) and active 11β-hydroxyl forms (cortisol and corticosterone). In mammals, two 11β-hydroxysteroid dehydrogenases (11β-HSD1 and 11β-HSD2) interconvert active and inactive glucocorticoids, allowing tissue-specific regulation of glucocorticoid action...
February 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/27914912/identification-of-foxj1-effectors-during-ciliogenesis-in-the-foetal-respiratory-epithelium-and-embryonic-left-right-organiser-of-the-mouse
#18
Michael Stauber, Marina Weidemann, Oliver Dittrich-Breiholz, Katharina Lobschat, Leonie Alten, Michaela Mai, Anja Beckers, Michael Kracht, Achim Gossler
Formation of motile cilia in vertebrate embryos is essential for proper development and tissue function. Key regulators of motile ciliogenesis are the transcription factors FOXJ1 and NOTO, which are conserved throughout vertebrates. Downstream target genes of FOXJ1 have been identified in a variety of species, organs and cultured cell lines; in murine embryonic and foetal tissues, however, FOXJ1 and NOTO effectors have not been comprehensively analysed and our knowledge of the downstream genetic programme driving motile ciliogenesis in the mammalian lung and ventral node is fragmentary...
March 15, 2017: Developmental Biology
https://www.readbyqxmd.com/read/27771218/structure-supramolecular-organization-and-phase-behavior-of-n-acyl-%C3%AE-alanines-structural-homologues-of-mammalian-brain-constituents-n-acylglycine-and-n-acyl-gaba
#19
D Sivaramakrishna, Musti J Swamy
N-Acyl-β-alanines (NABAs) are structural homologues of N-acylglycines (NAGs) and N-acyl-γ-aminobutyric acids (NAGABAs), and achiral isomers of N-acylalanines, which are all present in mammalian brain and other tissues and modulate activity of biological receptors with various functions. In the present study, we synthesized and characterized a homologous series of NABAs bearing saturated acyl chains (n=8-20) and investigated their supramolecular organization and thermotropic phase behavior. In differential scanning calorimetric (DSC) studies, most of the NABAs gave one or two minor transitions before the main chain-melting phase transition in the dry state as well as upon hydration with water, but gave only a single transition when hydrated with buffer (pH7...
December 2016: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/27751905/the-conserved-regulation-of-mitochondrial-uncoupling-proteins-from-unicellular-eukaryotes-to-mammals
#20
REVIEW
Andrzej M Woyda-Ploszczyca, Wieslawa Jarmuszkiewicz
Uncoupling proteins (UCPs) belong to the mitochondrial anion carrier protein family and mediate regulated proton leak across the inner mitochondrial membrane. Free fatty acids, aldehydes such as hydroxynonenal, and retinoids activate UCPs. However, there are some controversies about the effective action of retinoids and aldehydes alone; thus, only free fatty acids are commonly accepted positive effectors of UCPs. Purine nucleotides such as GTP inhibit UCP-mediated mitochondrial proton leak. In turn, membranous coenzyme Q may play a role as a redox state-dependent metabolic sensor that modulates the complete activation/inhibition of UCPs...
January 2017: Biochimica et Biophysica Acta
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