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https://www.readbyqxmd.com/read/29769561/transcriptome-analysis-of-circulating-pbmcs-to-understand-mechanism-of-high-altitude-adaptation-in-native-cattle-of-ladakh-region
#1
Preeti Verma, Ankita Sharma, Monika Sodhi, Kiran Thakur, Ranjit S Kataria, Saket K Niranjan, Vijay K Bharti, Prabhat Kumar, Arup Giri, Sahil Kalia, Manishi Mukesh
Ladakhi cattle is native population of Leh and Ladakh region and constantly exposed to hypobaric hypoxia over many generations. In present study, transcriptome signatures of cattle from Ladakh region (~5500 m) and Sahiwal cattle from tropical regions were evaluated using Agilent 44 K microarray chip. The top up-regulated genes in Ladakhi cows were INHBC, ITPRI, HECA, ABI3, GPR171, and HIF-1α involved in hypoxia and stress response. In Sahiwal cows, the top up-regulated genes eEF1A1, GRO1, CXCL2, DEFB3 and BOLA-DQA3 were associated with immune function and inflammatory response indicating their strong immune potential to combat the pathogens prevalent in the tropical conditions...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29765322/therapeutic-potential-of-ginsenosides-as-an-adjuvant-treatment-for-diabetes
#2
REVIEW
Litao Bai, Jialiang Gao, Fan Wei, Jing Zhao, Danwei Wang, Junping Wei
Ginseng, one of the oldest traditional Chinese medicinal herbs, has been used widely in China and Asia for thousands of years. Ginsenosides extracted from ginseng, which is derived from the roots and rhizomes of Panax ginseng C. A. Meyer, have been used in China as an adjuvant in the treatment of diabetes mellitus. Owing to the technical complexity of ginsenoside production, the total ginsenosides are generally extracted. Accumulating evidence has shown that ginsenosides exert antidiabetic effects. In vivo and in vitro tests revealed the potential of ginsenoside Rg1, Rg3, Rg5, Rb1, Rb2, Rb3, compound K, Rk1, Re, ginseng total saponins, malonyl ginsenosides, Rd, Rh2, F2, protopanaxadiol (PPD) and protopanaxatriol (PPT)-type saponins to treat diabetes and its complications, including type 1 diabetes mellitus, type 2 diabetes mellitus, diabetic nephropathy, diabetic cognitive dysfunction, type 2 diabetes mellitus with fatty liver disease, diabetic cerebral infarction, diabetic cardiomyopathy, and diabetic erectile dysfunction...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29762853/caffeine-induces-metformin-anticancer-effect-on-fibrosarcoma-in-hamsters
#3
D J Popović, D Lalošević, D Miljković, K J Popović, I Čapo, J K Popović
OBJECTIVE: We investigated the effect of metformin and caffeine on fibrosarcoma in hamsters. MATERIALS AND METHODS: 32 Syrian golden hamsters of both sexes, weighing approximately 100 g, were randomly allocated to 3 experimental and 2 control groups, with a minimum of 6 animals per group. 2 x 106 BHK-21/C13 cells in 1 ml were injected subcutaneously into the animals' back in 4 groups. The first experimental group started peroral treatment with metformin 500 mg/kg daily, the second with caffeine 100 mg/kg daily and the third with a combination of metformin 500 mg/kg and caffeine 100 mg/kg daily, via a gastric probe 3 days before tumor inoculation...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29751049/increased-butyrate-priming-in-the-gut-stalls-microbiome-associated-gastrointestinal-inflammation-and-hepatic-metabolic-reprogramming-in-a-mouse-model-of-gulf-war-illness
#4
Ratanesh Kumar Seth, Diana Kimono, Firas Alhasson, Sutapa Sarkar, Muayad Albadrani, Stephen K Lasley, Ronnie Horner, Patricia Janulecewicz, Mitzi Nagarkatti, Prakash Nagarkatti, Kimberly Sullivan, Saurabh Chatterjee
Most of the associated pathologies in Gulf War Illness (GWI) have been ascribed to chemical and pharmaceutical exposures during the war. Since an increased number of veterans complain of gastrointestinal (GI), neuroinflammatory and metabolic complications as they age and there are limited options for a cure, the present study was focused to assess the role of butyrate, a short chain fatty acid for attenuating GWI-associated GI and metabolic complications. Results in a GWI-mouse model of permethrin and pyridostigmine bromide (PB) exposure showed that oral butyrate restored gut homeostasis and increased GPR109A receptor copies in the small intestine (SI)...
May 8, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29749561/use-of-carbon-steel-ball-bearings-to-determine-the-effect-of-biocides-and-corrosion-inhibitors-on-microbiologically-influenced-corrosion-under-flow-conditions
#5
Tijan Pinnock, Johanna Voordouw, Gerrit Voordouw
A consortium of sulfate-reducing bacteria consisting mostly of Desulfovibrio, Desulfomicrobium, and Desulfocurvus from oil field produced water was cultivated in a chemostat, receiving medium with 20 mM formate and 10 mM sulfate as the energy and 1 mM acetate as the carbon source. The chemostat effluent, containing 5 mM sulfide and 0.5 mM of residual acetate, was passed through 1-ml syringe columns with 60 carbon steel ball bearings (BBs) of 53.6 ± 0.1 mg each at a flow rate of 0.8 ml/h per column...
May 10, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29747061/serrated-epithelial-colorectal-polyps-hyperplastic-polyps-sessile-serrated-adenomas-with-perineurial-stroma-clinicopathological-and-molecular-analysis-of-a-new-series
#6
Katharina Erlenbach-Wünsch, Michel Bihl, Arndt Hartmann, Gabriel M Groisman, Michael Vieth, Abbas Agaimy
Serrated colorectal fibroblastic polyps (FPs) are rare benign mucosal lesions composed of serrated epithelial crypts separated and distorted by intimately associated bland spindle cell proliferations with perineurial-like phenotype. We herein describe 21 new FPs affecting 10 females and 9 males aged 45 to 80 yrs. (mean, 62 yrs). Lesions originated in the sigmoid colon/rectosigmoid junction (n = 16), rectum (n = 2), and other parts of the colon (n = 3). Most patients had additional synchronous or metachronous polyps: classical adenomas (12 patients), sessile serrated adenoma/SSA (1 patient), hyperplastic polyps/HPs (7 patients), both HPs and adenomas (6 patients) and colorectal cancer (2 patients)...
May 4, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29746779/energy-metabolism-drugs-block-triple-negative-breast-metastatic-cancer-cell-phenotype
#7
Silvia Cecilia Pacheco-Velazquez, Diana Xochiquetzal Robledo-Cadena, Ileana Hernández-Reséndiz, Juan Carlos Gallardo-Pérez, Rafael Moreno-Sánchez, Sara Rodríguez-Enríquez
To establish alternative targeted therapies against triple negative (TN) breast cancer, (1) the energy metabolism and (2) the sensitivity of cell growth, migration and invasiveness towards metabolic, canonical and NSAID inhibitors was analyzed in MDA-MB-231 and MDA-MB-468, two TN metastatic breast cancer cell lines, under both normoxia (21% O2) and hypoxia (0.1% O2). For comparative purposes, analysis was also carried out in the less-metastatic breast MCF-7 cancer cells. Under normoxia, oxidative phosphorylation (OxPhos) was significantly higher (2-times) in MDA-MB-468 than in MDA-MB-231 and MCF-7 whereas their glycolytic fluxes and OxPhos and glycolytic protein contents were all similar...
May 10, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29737040/marked-accumulation-of-fdg-and-inflammatory-cells-expressing-glucose-transporter-3-in-igg4-related-autoimmune-hepatitis
#8
Toshihiro Araki, Teruko Arinaga-Hino, Hironori Koga, Jun Akiba, Tatsuya Ide, Yoshinobu Okabe, Reiichiro Kuwahara, Keisuke Amano, Makiko Yasumoto, Toshihiro Kawaguchi, Tomoya Sano, Reiichiro Kondou, Seiji Kurata, Keiichi Mitsuyama, Takuji Torimura
Immunoglobulin G (IgG) 4 related-autoimmune hepatitis (AIH) is a recently proposed subtype that responds well to steroid treatment; however, its pathogenesis remains unclear. We report here a 65-year-old Japanese female with skin itching and lip swelling. She had liver injury with jaundice, which persisted despite stopping of anti-allergic agents. Blood chemistry revealed highly elevated serum IgG and IgG4 (535 mg/dL) levels, and positive anti-nuclear antibody. The diagnosis of AIH was based on liver biopsy...
May 7, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29707805/intestinal-absorption-of-glucose-in-mice-as-determined-by-positron-emission-tomography
#9
Monica Sala-Rabanal, Chiara Ghezzi, Bruce A Hirayama, Vladimir Kepe, Jie Liu, Jorge R Barrio, Ernest M Wright
KEY POINTS: The goal was to determine the importance of the sodium glucose cotransporter SGLT1 and the glucose uniporter GLUT2 in intestinal glucose absorption during oral glucose tolerance tests (OGTTs) in mice. Glucose absorption was determined in mice using positron emission tomography and three non-metabolizable glucose probes: one specific for SGLTs, one specific for GLUTs, and one a substrate for both SGLTs and GLUTs. Absorption was determined in wild-type, Sglt1-/- , and Glut2-/- mice...
April 29, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29691457/metabolic-and-cardiac-adaptation-to-chronic-pharmacologic-blockade-of-facilitative-glucose-transport-in-murine-dilated-cardiomyopathy-and-myocardial-ischemia
#10
Monique R Heitmeier, Maria A Payne, Carla Weinheimer, Attila Kovacs, Richard C Hresko, Patrick Y Jay, Paul W Hruz
GLUT transgenic and knockout mice have provided valuable insight into the role of facilitative glucose transporters (GLUTs) in cardiovascular and metabolic disease, but compensatory physiological changes can hinder interpretation of these models. To determine whether adaptations occur in response to GLUT inhibition in the failing adult heart, we chronically treated TG9 mice, a transgenic model of dilated cardiomyopathy and heart failure, with the GLUT inhibitor ritonavir. Glucose tolerance was significantly improved with chronic treatment and correlated with decreased adipose tissue retinol binding protein 4 (RBP4) and resistin...
April 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29686650/glucose-transporters-in-diabetic-kidney-disease-friends-or-foes
#11
REVIEW
Anita A Wasik, Sanna Lehtonen
Diabetic kidney disease (DKD) is a major microvascular complication of diabetes and a common cause of end-stage renal disease worldwide. DKD manifests as an increased urinary protein excretion (albuminuria). Multiple studies have shown that insulin resistance correlates with the development of albuminuria in non-diabetic and diabetic patients. There is also accumulating evidence that glomerular epithelial cells or podocytes are insulin sensitive and that insulin signaling in podocytes is essential for maintaining normal kidney function...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29684818/glut1-protects-prostate-cancer-cells-from-glucose-deprivation-induced-oxidative-stress
#12
Pedro Gonzalez-Menendez, David Hevia, Rebeca Alonso-Arias, Alejandro Alvarez-Artime, Aida Rodriguez-Garcia, Sandrina Kinet, Ivan Gonzalez-Pola, Naomi Taylor, Juan C Mayo, Rosa M Sainz
Glucose, chief metabolic support for cancer cell survival and growth, is mainly imported into cells by facilitated glucose transporters (GLUTs). The increase in glucose uptake along with tumor progression is due to an increment of facilitative glucose transporters as GLUT1. GLUT1 prevents cell death of cancer cells caused by growth factors deprivation, but there is scarce information about its role on the damage caused by glucose deprivation, which usually occurs within the core of a growing tumor. In prostate cancer (PCa), GLUT1 is found in the most aggressive tumors, and it is regulated by androgens...
April 12, 2018: Redox Biology
https://www.readbyqxmd.com/read/29680740/moringa-concanensis-nimmo-ameliorates-hyperglycemia-in-3t3-l1-adipocytes-by-upregulating-ppar-%C3%AE-c-ebp-%C3%AE-via-akt-signaling-pathway-and-stz-induced-diabetic-rats
#13
Brindha Banu Balakrishnan, Kalaivani Krishnasamy, Ki Choon Choi
Moringa concanensis Nimmo is a medicinal plant for treating various human illnesses including menstrual pain, high blood pressure, jaundice, inflammation, pain, fever, sore eyes, and cholesterol in Indian folk medicine. Despite its versatility, its antihyperglycemic mechanism of action (in vitro and in vivo) remains unclear. Therefore, in this study we developed the possible antihyperglycemic mechanism of action in 3T3-L1 cells by evaluating mRNA and protein expression, which are associated with adipogenesis and lipogenesis (insulin sensitizer)...
April 19, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29680068/impact-of-lactobacillus-plantarum-on-thiol-precursor-biotransformation-leading-to-production-of-3-sulfanylhexan-1-ol
#14
Hideki Takase, Kanako Sasaki, Daiki Kiyomichi, Hironori Kobayashi, Hironori Matsuo, Ryoji Takata
3-Sulfanylhexan-1-ol (3SH) is an important contributor to the fruity notes of wine. 3SH exists as odorless precursors in grape and its release from the precursors is generally mediated by yeast during alcoholic fermentation. Here, the impact of lactic acid bacteria on 3SH production was investigated. Among the species tested, only Lactobacillus plantarum released 3SH from S-3-(hexan-1-ol)-l-cysteine (3SH-S-cys) and S-3-(hexan-1-ol)-l-cysteinylglycine (3SH-S-cysgly) in the whole-cell biotransformation assay...
September 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29676955/mitochondrial-genome-modulates-myocardial-akt-glut-hk-salvage-pathway-in-spontaneously-hypertensive-rats-adapted-to-chronic-hypoxia
#15
Iveta Nedvedova, David Kolar, Barbara Elsnicova, Daniela Hornikova, Jiri Novotny, Martin Kalous, Michal Pravenec, Jan Neckar, Frantisek Kolar, Jitka M Zurmanova
Recently we have shown that adaptation to continuous normobaric hypoxia (CNH) decreases myocardial ischemia/reperfusion injury in spontaneously hypertensive rats (SHR) and in conplastic strain (SHR-mtBN ). The protective effect was stronger in the latter group characterized by a selective replacement of SHR mitochondrial genome with that of a more ischemia-resistant Brown Norway strain. The aim of the present study was to examine the possible involvement of the hypoxia inducible factor (HIF)-dependent pathway of the protein kinase B/glucose transporters/hexokinase (Akt/GLUT/HK) in this mitochondrial genome-related difference of the cardioprotective phenotype...
April 20, 2018: Physiological Genomics
https://www.readbyqxmd.com/read/29676131/-jatrorrhizine-regulates-gluts-with-multiple-manners-for-hypoglycemic-effect-in-insulin-resistance-3t3-l1-adipocytes
#16
Shui-Lan Zhu, Ting Lei, Xu Gao, Jun Tu
This paper aimed to investigate the hypoglycemic effect and relative mechanism of jatrorrhizine in insulin-resistance (IR)-3T3-L1 adipocytes. The 3T3-L1 preadipocytes were used to induce mature adipocytes, then the stable IR model was established with 1 μmol·L⁻¹ dexamethasone. The adipocytes were divided into normal group, IR model group, rosiglitazone positive group and jatrorrhizine group (0.5, 1, 5, 10, 20 μmol·L⁻¹). After different time points (12, 24, 30, 36, 48 h) treatment, glucose content of 3T3-L1 adipocytes was detected by the glucose oxidase peroxidase method and TG content was measured by glycerol phosphate oxidase method, whereas cell viability was detected by CCK-8 assay...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29674524/insulin-receptor-plasma-membrane-levels-increased-by-the-progesterone-receptor-membrane-component-1
#17
Kaia K Hampton, Hilaree Frazier, Katie Anderson, Olivier Thibault, Rolf J Craven
The Insulin Receptor (IR) is a ligand-activated receptor tyrosine kinase that has a key role in metabolism, cellular survival and proliferation. Progesterone receptor membrane component 1 (PGRMC1) promotes cellular signaling via receptor trafficking, and is essential for some elements of tumor growth and metastasis. In the present study, we demonstrate that PGRMC1 co-precipitates with IR. Furthermore, we show that PGRMC1 increases plasma membrane IR levels in multiple cell lines and decreases insulin binding at the cell surface...
April 19, 2018: Molecular Pharmacology
https://www.readbyqxmd.com/read/29674266/effects-of-high-protein-diet-containing-isolated-whey-protein-in-rats-submitted-to-resistance-training-of-aquatic-jumps
#18
Eudes Thiago Pereira Avila, Thiago da Rosa Lima, Ramires Alsamir Tibana, Paula Caroline de Almeida, Géssica Alves Fraga, Mariana de Souza Sena, Luiz Felipe Petusk Corona, James Wilfred Navalta, Sajjad Rezaei, Morteza Ghayomzadeh, Amílcar Sabino Damazo, Jonato Prestes, Fabrício Azevedo Voltarelli
OBJECTIVES: Isolated whey protein (IWP) can decrease body fat compared with other protein sources. The present study verified the effects of high protein diet (HD) containing IWP on several parameters of rats subjected to resistance training (RT). METHODS: Thirty-two male Wistar rats (60 days of age) were separated into four groups (n = 8/group): sedentary normoproteic (IWP 14%; SN); sedentary hyperproteic (IWP 35%; SH); trained normoproteic (IWP 14%; TN), and trained hyperproteic (WPI 35%; TH)...
February 13, 2018: Nutrition
https://www.readbyqxmd.com/read/29660430/the-protective-effect-of-hif3a-rna-interference-and-hif-prolyl-hydroxylase-inhibition-on-cardiomyocytes-under-anoxia-reoxygenation
#19
T Drevytska, E Gonchar, I Okhai, O Linnyk, I Mankovska, D Klionsky, V Dosenko
The aim of this study was to investigate the molecular mechanisms underlying the protective effects of hypoxia-inducible factor (HIF) signaling pathway activation in cardiomyocytes under anoxia-reoxygenation (A/R) injury. In this study, rat neonatal cardiomyocytes were pretreated with anti-Hif3A/Hif-3α siRNA or HIF-prolyl hydroxylase inhibitor prior to A/R injury. Our results showed that both HIF3A silencing and HIF-prolyl hydroxylase inhibition effectively increased the cell viability during A/R, led to changes in mRNA expression of HIF1-target genes, and reduced the loss of mitochondrial membrane potential (Δψm )...
April 13, 2018: Life Sciences
https://www.readbyqxmd.com/read/29658475/-aerobic-glycolysis-activation-through-canonical-wnt-%C3%AE-catenin-pathway-in-als
#20
Alexandre Vallée
Energy is the major determinant of neuronal viability. We focus our synthesis on the hypothesis of the development of aerobic glycolysis by the stimulation of the canonical WNT/β-catenin pathway in amyotrophic lateral sclerosis (ALS). The stimulation of the canonical WNT/β-catenin pathway induces the activation of aerobic glycolysis, also called Warburg effect, via the stimulation of glycolytic enzymes such as Glut (glucose transporter), PKM2 (pyruvate kinase M2), PDK1 (pyruvate dehydrogenase kinase 1), LDH-A (lactate dehydrogenase A) and MCT-1 (monocarboxylate transporter 1)...
April 2018: Médecine Sciences: M/S
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