keyword
https://read.qxmd.com/read/36868927/genetic-risk-score-for-common-obesity-and-anthropometry-in-spanish-schoolchildren
#21
JOURNAL ARTICLE
Andrea Calderón García, Ana Alaminos-Torres, Roberto Pedrero Tomé, Consuelo Prado Martínez, Jesús Román Martínez Álvarez, Antonio Villarino Marín, Noemí López Ejeda, María Dolores Marrodán Serrano
IntroductionCommon or non-syndromic obesity is a complex polygenic trait conditioned by biallelic or single-base polymorphisms called SNPs (Single-Nucleotide Polymorphisms) that present an additive effect and act synergistically. Most genotype-obese phenotype association studies include body mass index (BMI) or waist-to-height ratio (WtHR), and very few introduce a broad anthropometric profile. ObjectiveTo verify whether a genetic risk score (GRS) developed from 10 SNPs is associated with the obesity phenotype assessed from anthropometric measures indicative of excess weight, adiposity and fat distribution...
March 1, 2023: Endocrinología, diabetes y nutrición
https://read.qxmd.com/read/36669582/towards-the-development-of-a-biorelevant-in-vitro-method-for-the-prediction-of-nanoemulsion-stability-on-the-ocular-surface
#22
JOURNAL ARTICLE
Bisera Jurišić Dukovski, Josip Ljubica, Petra Kocbek, Maša Safundžić Kučuk, Iva Krtalić, Anita Hafner, Ivan Pepić, Jasmina Lovrić
Ophthalmic oil-in-water nanoemulsions (NEs) are a complex technological platform, representing an advancement in the treatment of dry eye disease. In addition to enabling the incorporation of poorly soluble active pharmaceutical ingredients (APIs), NEs provide prolonged residence time of APIs and other formulation components and consequent replenishment and stabilization of the compromised tear film. Ophthalmic NEs have been on the market for over 20 years, but considering their complexity, as well as the complex nature of the ocular surface, they are still a poorly understood advanced dosage form...
January 17, 2023: International Journal of Pharmaceutics
https://read.qxmd.com/read/36449570/high-resolution-analysis-of-the-cytosolic-ca-2-events-in-beta-cell-collectives-in-situ
#23
JOURNAL ARTICLE
Sandra Postić, Srdjan Sarikas, Johannes Pfabe, Viljem Pohorec, Lidija Križančić Bombek, Nastja Sluga, Maša Skelin Klemen, Jurij Dolenšek, Dean Korošak, Andraž Stozer, Carmella Evans-Molina, James D Johnson, Marjan Slak Rupnik
The release of peptide hormones is predominantly regulated by a transient increase in cytosolic Ca2+ concentration ([Ca2+ ]c ). To trigger exocytosis, Ca2+ ions enter the cytosol from intracellular Ca2+ stores or from the extracellular space. The molecular events of late stages of exocytosis, and their dependence on [Ca2+ ]c , were extensively described in isolated single cells from various endocrine glands. Notably less work has been done on endocrine cells in situ to address the heterogeneity of [Ca2+ ]c events contributing to a collective functional response of a gland...
November 30, 2022: American Journal of Physiology. Endocrinology and Metabolism
https://read.qxmd.com/read/36329388/serum-zinc-values-ankle-brachial-index-and-mortality-in-hemodialysis-patients
#24
JOURNAL ARTICLE
Maša Knehtl, Nejc Piko, Robert Ekart, Radovan Hojs, Sebastjan Bevc
INTRODUCTION: The atherosclerotic state of haemodialysis (HD) patients may be influenced by heavy metals. The purpose of our study was to assess the relationship between serum zinc (Zn) ankle brachial index (ABI) as a non-invasive diagnostic tool for atherosclerosis, and mortality in chronic haemodialysis (HD) patients. METHODS: Sixty one HD patients were included (mean age 61.2 ± 13.8 years). The ABI was measured with an automated measuring device (ABPI MD, MESI®, Slovenia)...
November 4, 2022: BMC Nephrology
https://read.qxmd.com/read/36327114/percentiles-of-body-mass-index-and-waist-circumference-for-costa-rican-children-and-adolescents
#25
JOURNAL ARTICLE
Hilda Patricia Núñez-Rivas, Ileana Holst-Schumacher, Natalia Campos-Saborío, Erasmo López-López
INTRODUCTION: body mass index (BMI) and waist circumference (WC) are anthropometric indicators used to define overweight/obesity and to predict the risk of cardiovascular disease, respectively, in adolescents and children. OBJECTIVES: to describe and provide estimations of BMI and WC distribution according to percentiles in a sample of Costa Rican students, and to test group differences at the 50th percentile with the international references by the National Center for Health Statistics of the United States of America in 2012, 2016 and 2021...
November 3, 2022: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://read.qxmd.com/read/36211494/validation-of-the-food-frequency-questionnaire-for-the-assessment-of-dietary-vitamin-d-intake
#26
JOURNAL ARTICLE
Maša Hribar, Katarina Žlavs, Igor Pravst, Katja Žmitek
Vitamin D and its adequate status are related to many aspects of human health; therefore, an appropriate tool is needed for the valid assessment of vitamin D status. The main contributor to vitamin D status is endogenous synthesis after cutaneous exposure to ultraviolet B light (UVB), but in the absence of UVB radiation, vitamin D intake becomes an important source of vitamin D. Various tools are available for vitamin D intake assessments, with the Food Frequency Questionnaire (FFQ) being among the fastest, cheapest, and most convenient; however, until now, these tools have not been adapted for the Slovenia (SI)...
2022: Frontiers in Nutrition
https://read.qxmd.com/read/36167837/development-of-a-remote-examination-of-deglutition-based-on-consensus-surveys-of-clinicians-part-ii-reliability-and-validity-in-healthy-elderly-individuals-and-oral-cancer-patients
#27
JOURNAL ARTICLE
Fumitaka Omori, Masako Fujiu-Kurachi, Kaori Wada, Takafumi Yamano
In our prior published study, we extracted evaluation items suitable for remote administration, and made a relatively simple Remote Examination of Deglutition (RED). This study aimed at verifying the reliability and validity of RED. The participants were 21 healthy elderly individuals and 72 postoperative oral cancer (OC) patients. OC patients underwent videofluoroscopic dysphagia examination, and severity was judged on the dysphagia severity scale (DSS). Reliability and validity of RED were examined in all participants under face-to-face conditions, in comparison with the Mann Assessment of Swallowing Ability (MASA)...
September 27, 2022: Dysphagia
https://read.qxmd.com/read/36155522/inflammation-related-micrornas-146a-and-155-are-upregulated-in-mild-cognitive-impairment-subjects-among-older-age-population-in-montenegro
#28
JOURNAL ARTICLE
Isidora Rovčanin Dragović, Nataša Popović, Maša Ždralević, Ljiljana Radulović, Miodrag Radunović
BACKGROUND: Pathological and clinical features of Alzheimer's disease (AD) are in temporal discrepancy and currently accepted clinical tests provide the diagnosis decades after the initial pathophysiological events. In order to enable a more timely detection of AD, research efforts are directed to identification of biomarkers of the early symptomatic stage. Neuroinflammatory signaling pathways and inflammation-related microRNAs (miRNAs) could possibly have a crucial role in AD, making them promising potential biomarkers...
September 19, 2022: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/36134593/sensitivity-and-specificity-of-body-mass-index-and-main-risk-factors-for-cardiovascular-disease-in-middle-income-urban-participants-in-guanajuato-mexico
#29
JOURNAL ARTICLE
Susana Del Refugio Ruiz González, Rebeca Monroy Torres, Juan Manuel Malacara, Rodolfo Guardado-Mendoza
INTRODUCTION: several studies have questioned body mass index (BMI) as an accurate diagnostic tool for obesity and therefore a predictor of cardiovascular risk. But BMI is widely used currently. OBJECTIVE: we analyzed the sensitivity and specificity of BMI and compared cardiovascular risk factors in middle-income urban participants in Guanajuato, Mexico, at different ages. DESIGN: an analytical and cross-sectional study was carried out in 385 apparently healthy subjects, stratified by age ranges (20 to 59 years old)...
September 20, 2022: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://read.qxmd.com/read/36065640/proton-transporting-heliorhodopsins-from-marine-giant-viruses
#30
JOURNAL ARTICLE
Shoko Hososhima, Ritsu Mizutori, Rei Abe-Yoshizumi, Andrey Rozenberg, Shunta Shigemura, Alina Pushkarev, Masae Konno, Kota Katayama, Keiichi Inoue, Satoshi P Tsunoda, Oded Béjà, Hideki Kandori
Rhodopsins convert light into signals and energy in animals and microbes. Heliorhodopsins (HeRs), a recently discovered new rhodopsin family, are widely present in archaea, bacteria, unicellular eukaryotes, and giant viruses, but their function remains unknown. Here, we report that a viral HeR from Emiliania huxleyi virus 202 (V2HeR3) is a light-activated proton transporter. V2HeR3 absorbs blue-green light, and the active intermediate contains the deprotonated retinal Schiff base. Site-directed mutagenesis study revealed that E191 in TM6 constitutes the gate together with the retinal Schiff base...
September 6, 2022: ELife
https://read.qxmd.com/read/36058400/dysphagia-in-solid-tumors-outside-the-head-neck-or-upper-gi-tract-clinical-characteristics
#31
JOURNAL ARTICLE
Ciarán Kenny, Julie Regan, Lucy Balding, Stephen Higgins, Norma O'Leary, Fergal Kelleher, Ray McDermott, John Armstrong, Alina Mihai, Eoin Tiernan, Jennifer Westrup, Pierre Thirion, Declan Walsh
CONTEXT: Dysphagia is common in cancer, but underlying pathophysiology and manifestations within patients are unknown. OBJECTIVES: To examine dysphagia characteristics in those with solid malignancies outside the head, neck and upper gastrointestinal tract. METHODS: Seventy-three individuals with dysphagia (46 male, 27 female, aged 37-91) were recruited from a parent trial conducted in two acute hospitals and one hospice. Cranial nerve function, Oral Health Assessment Tool (OHAT), Mann Assessment of Swallowing Ability (MASA) and Functional Oral Intake Scale (FOIS) evaluated swallow profile...
September 1, 2022: Journal of Pain and Symptom Management
https://read.qxmd.com/read/36011376/genetics-of-pediatric-epilepsy-next-generation-sequencing-in-clinical-practice
#32
JOURNAL ARTICLE
Antonela Blazekovic, Kristina Gotovac Jercic, Sarah Meglaj, Vlasta Duranovic, Igor Prpic, Bernarda Lozic, Masa Malenica, Silvana Markovic, Lucija Lujic, Zeljka Petelin Gadze, Romana Gjergja Juraski, Nina Barišic, Ivo Baric, Fran Borovecki
Epilepsy is one of the most common neurological disorders with diverse phenotypic characteristics and high genetic heterogeneity. Epilepsy often occurs in childhood, so timely diagnosis and adequate therapy are crucial for preserving quality of life and unhindered development of a child. Next-generation-sequencing (NGS)-based tools have shown potential in increasing diagnostic yield. The primary objective of this study was to evaluate the impact of genetic testing and to investigate the diagnostic utility of targeted gene panel sequencing...
August 17, 2022: Genes
https://read.qxmd.com/read/36004044/successful-treatment-of-recurrent-cardiac-sarcoidosis-with-the-combination-of-corticosteroid-and-methotrexate-monitored-by-18-f-fluoro-2-deoxyglucose-positron-emission-tomography-case-series
#33
Masato Ishizuka, Masae Uehara, Mikako Katagiri, Junichi Ishida, Toshiya Kojima, Eisuke Amiya, Issei Komuro
Background: The standard treatment for cardiac sarcoidosis (CS) is corticosteroids, including prednisolone (PSL). Previous studies have shown that the addition of methotrexate (MTX) to PSL is effective for steroid-refractory and recurrent cases. 18 F-fluoro-2-deoxyglucose positron emission tomography (FDG-PET) is an essential tool for the diagnosis of CS. However, it is unclear whether FDG-PET is useful for detecting recurrence of CS and monitoring the effectiveness of PSL and MTX combination therapy...
August 2022: European Heart Journal. Case Reports
https://read.qxmd.com/read/35071700/3d-dataset-of-binary-images-a-collection-of-synthetically-created-digital-rock-images-of-complex-media
#34
JOURNAL ARTICLE
Javier E Santos, Michael J Pyrcz, Maša Prodanović
Digital rock images are computational representations that capture the geometrical complexity of systems present ubiquitously in nature. In recent years, their use has become widespread due to the increasing availability of repositories, and open-source physics simulators and analysis tools. Here, we present a dataset of 3D binary geometries in a standardized format that represent a wide variety of geological and engineering systems. Our data is freely available at [1].
February 2022: Data in Brief
https://read.qxmd.com/read/34723069/advanced-machine-learning-tools-to-monitor-biomarkers-of-dysphagia-a-wearable-sensor-proof-of-concept-study
#35
JOURNAL ARTICLE
Megan K O'Brien, Olivia K Botonis, Elissa Larkin, Julia Carpenter, Bonnie Martin-Harris, Rachel Maronati, KunHyuck Lee, Leora R Cherney, Brianna Hutchison, Shuai Xu, John A Rogers, Arun Jayaraman
Introduction: Difficulty swallowing (dysphagia) occurs frequently in patients with neurological disorders and can lead to aspiration, choking, and malnutrition. Dysphagia is typically diagnosed using costly, invasive imaging procedures or subjective, qualitative bedside examinations. Wearable sensors are a promising alternative to noninvasively and objectively measure physiological signals relevant to swallowing. An ongoing challenge with this approach is consolidating these complex signals into sensitive, clinically meaningful metrics of swallowing performance...
May 2021: Digital Biomarkers
https://read.qxmd.com/read/34661279/screening-for-aspiration-risk-associated-with-dysphagia-in-acute-stroke
#36
REVIEW
Elizabeth Boaden, Jane Burnell, Lucy Hives, Paola Dey, Andrew Clegg, Mary W Lyons, C Elizabeth Lightbody, Margaret A Hurley, Hazel Roddam, Elizabeth McInnes, Anne Alexandrov, Caroline L Watkins
BACKGROUND: Stroke can affect people's ability to swallow, resulting in passage of some food and drink into the airway. This can cause choking, chest infection, malnutrition and dehydration, reduced rehabilitation, increased risk of anxiety and depression, longer hospital stay, increased likelihood of discharge to a care home, and increased risk of death. Early identification and management of disordered swallowing reduces risk of these difficulties. OBJECTIVES: Primary objective • To determine the diagnostic accuracy and the sensitivity and specificity of bedside screening tests for detecting risk of aspiration associated with dysphagia in people with acute stroke Secondary objectives • To assess the influence of the following sources of heterogeneity on the diagnostic accuracy of bedside screening tools for dysphagia - Patient demographics (e...
October 18, 2021: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/34623394/inucs-inter-nucleosome-interactions
#37
JOURNAL ARTICLE
Mehrdad Oveisi, Manu Shukla, Nogayhan Seymen, Masae Ohno, Yuichi Taniguchi, Sunil Nahata, Remco Loos, Ghulam J Mufti, Robin C Allshire, Stefan Dimitrov, Mohammad M Karimi
MOTIVATION: Deciphering nucleosome-nucleosome interactions is an important step towards mesoscale description of chromatin organization but computational tools to perform such analyses are not publicly available. RESULTS: We developed iNucs, a user-friendly and efficient Python-based bioinformatics tool to compute and visualize nucleosome resolved interactions using standard pairs format input generated from pairtools. AVAILABILITY: https://github...
October 8, 2021: Bioinformatics
https://read.qxmd.com/read/34621174/effects-of-bisphenols-on-rack1-expression-and-their-immunological-implications-in-thp-1-cells
#38
JOURNAL ARTICLE
Erica Buoso, Maša Kenda, Mirco Masi, Pasquale Linciano, Valentina Galbiati, Marco Racchi, Marija Sollner Dolenc, Emanuela Corsini
Receptor for activated C kinase 1 (RACK1) has an important role in immune activation, and is regulated through a balance between glucocorticoid and androgen levels. We have previously demonstrated that RACK1 expression can serve as a marker for evaluation of immunotoxic profiles of hormone-active substances, such as endocrine-disrupting chemicals (EDCs). In this study, we investigated the effects of three bisphenols (BPA, BPAF, BPS) on RACK1 expression and on the innate immune responses in the THP-1 human promyelocytic cell line, a validated model for this investigation...
2021: Frontiers in Pharmacology
https://read.qxmd.com/read/34524936/primary-vs-specialist-care-for-obstructive-sleep-apnea-a-systematic-review-and-individual-participant-data-level-meta-analysis
#39
JOURNAL ARTICLE
Emer M Van Ryswyk, Iván D Benítez, Alexander M Sweetman, Nuria Nadal, Ching Li Chai-Coetzer, Juan Fernando Masa, Francisco Javier Gómez de Terreros, Robert J Adams, Manuel Sánchez-de-la-Torre, Nigel Stocks, Billingsley Kaambwa, R Doug McEvoy, Ferran Barbé
RATIONALE: Primary care clinicians may be well placed to play a greater role in obstructive sleep apnea management. OBJECTIVES: To evaluate the outcomes and cost-effectiveness of sleep apnea management in primary versus specialist care, using an individual-participant data meta-analysis to determine whether age, gender, severity of OSA and daytime sleepiness impacted outcomes. METHODS: Data sources were CINAHL, CENTRAL, MEDLINE Ovid SP, Scopus, ProQuest, US NIH Ongoing Trials Register, ISRCTN registry [inception until 09-25-2019]...
September 15, 2021: Annals of the American Thoracic Society
https://read.qxmd.com/read/34496542/-chinese-version-of-the-mann-assessment-of-swallowing-ability-oral-cancer-revision-and-evaluation-of-reliability-and-validity
#40
JOURNAL ARTICLE
Q Li, J Zhang, H Y Wu, X F Shan, Y He, Y Yang
Objective: To translate and revise the Mann assessment of swallowing ability-cancer (MASA-C) into Chinese according to postoperative patients with oral cancer and to evaluate the reliability and validity of Mann assessment of swallowing ability-oral cancer (MASA-OC) in postoperative patients with oral cancer. Methods: The MASA-C was translated into Chinese through pre-translation, reconciliation and back translation, then the Chinese MASA-C was revised to MASA-OC according to postoperative patients with oral cancer by expert panel and pre-investigation...
September 9, 2021: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
keyword
keyword
113944
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.