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https://www.readbyqxmd.com/read/27904591/brain-regions-involved-in-swallowing-evidence-from-stroke-patients-in-a-cross-sectional-study
#1
Shiva Ebrahimian Dehaghani, Fariba Yadegari, Ali Asgari, Ahmad Chitsaz, Mehdi Karami
BACKGROUND: Limited data available about the mechanisms of dysphagia and areas involving swallow after brain damage; accordingly it is hard to predict which cases are more likely to develop swallowing dysfunction based on the neuroimaging. The aim of this study was to investigate the relationship between brain lesions and dysphagia in a sample of acute conscious stroke patients. MATERIALS AND METHODS: In a cross-sectional study, 113 acute conscious stroke patients (69 male mean [standard deviation (SD)] age 64...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27755873/hydrogen-bonding-induced-fluorescence-water-soluble-and-polarity-independent-solvatochromic-fluorophores
#2
Yohei Okada, Masae Sugai, Kazuhiro Chiba
Fluorophores with emission wavelengths that shift depending on their hydrogen-bonding microenvironment in water would be fascinating tools for the study of biological events. Herein, we describe the design and synthesis of a series of water-soluble solvatochromic fluorophores, 2,5-bis(oligoethylene glycol)oxybenzaldehydes (8-11) and 2,5-bis(oligoethylene glycol)oxy-1,4-dibenzaldehydes (14-17), based on a push-pull strategy. Unlike typical examples in this class of fluorophores, the fluorescence properties of these compounds are independent of solvent polarity and become fluorescent upon intermolecular hydrogen-bonding, exhibiting high quantum yields (up to φ = 0...
October 18, 2016: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/27598377/sociodemographic-factors-and-health-conditions-associated-with-the-resilience-of-people-with-chronic-diseases-a-cross-sectional-study
#3
Julia Estela Willrich Böell, Denise Maria Guerreiro Vieira da Silva, Kathleen Mary Hegadoren
OBJECTIVE: to investigate the association between resilience and sociodemographic variables and the health of people with chronic kidney disease and / or type 2 diabetes mellitus. METHOD: a cross-sectional observational study performed with 603 people with chronic kidney disease and / or type 2 diabetes mellitus. A tool to collect socio-demographic and health data and the Resilience Scale developed by Connor and Davidson were applied. A descriptive and multivariate analysis was performed...
2016: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/27512702/validity-reliability-and-factor-analysis-of-persian-version-of-schizophrenia-quality-of-life-scale
#4
Nasrin Masaeli, Victoria Omranifard, Mohammad Reza Maracy, Gholam Reza Kheirabadi, Anahita Khedri
CONTEXT: Exact measurement of quality of life (QOL) in schizophrenia patients for evaluation of the patient's deterioration and also to assess the efficacy of therapeutic Interventions has become a daily task, which requires accurate assessment tools. AIMS: This study was aimed to assess the psychometric properties of a Persian version of schizophrenia QOL scale (SQLS) as a common transcultural instrument. SETTINGS AND DESIGN: One hundred and fifty schizophrenia patients who referred to Psychiatric Clinic in Noor Hospital (Isfahan, Iran) have been selected using simple sampling method...
2016: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/27195778/evaluation-of-a-dysphagia-screening-system-based-on-the-mann-assessment-of-swallowing-ability-for-use-in-dependent-older-adults
#5
Mariko Ohira, Ryo Ishida, Yoshinobu Maki, Mai Ohkubo, Tetsuya Sugiyama, Takaharu Sakayori, Toru Sato
AIM: Dysphagia is common in dependent older adults. Thus, a method of evaluating eating and swallowing functions that can be used to diagnose and manage dysphagia in a simple and robust manner is required. In 2002, the Mann Assessment of Swallowing Ability (MASA) was introduced to identify dysphagia in acute-stage stroke patients. As the MASA enables easy screening, it might also be applicable to dependent older adults if appropriate MASA cut-off values and the most useful assessment items could be determined...
May 16, 2016: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/27170062/a-rare-coincidence-of-sitosterolemia-and-familial-mediterranean-fever-identified-by-whole-exome-sequencing
#6
Hayato Tada, Masa-Aki Kawashiri, Hirofumi Okada, Saori Endo, Yuka Toyoshima, Tetsuo Konno, Atsushi Nohara, Akihiro Inazu, Akira Takao, Hiroshi Mabuchi, Masakazu Yamagishi, Kenshi Hayashi
Whole exome sequencing (WES) technologies have accelerated genetic studies of Mendelian disorders, yielding approximately 30% diagnostic success. We encountered a 13-year-old Japanese female initially diagnosed with familial hypercholesterolemia on the basis of clinical manifestations of severe hypercholesterolemia (initial LDL cholesterol=609 mg/dl at the age of one) and systemic intertriginous xanthomas with histories of recurrent self-limiting episodes of fever and arthritis. Both her phenotypes seemed to co-segregate in a recessive manner...
July 1, 2016: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/26921839/comparing-national-home-keeping-and-the-regulation-of-translational-stem-cell-applications-an-international-perspective
#7
Margaret Sleeboom-Faulkner, Choon Key Chekar, Alex Faulkner, Carolyn Heitmeyer, Marina Marouda, Achim Rosemann, Nattaka Chaisinthop, Hung-Chieh Jessica Chang, Adrian Ely, Masae Kato, Prasanna K Patra, Yeyang Su, Suli Sui, Wakana Suzuki, Xinqing Zhang
A very large grey area exists between translational stem cell research and applications that comply with the ideals of randomised control trials and good laboratory and clinical practice and what is often referred to as snake-oil trade. We identify a discrepancy between international research and ethics regulation and the ways in which regulatory instruments in the stem cell field are developed in practice. We examine this discrepancy using the notion of 'national home-keeping', referring to the way governments articulate international standards and regulation with conflicting demands on local players at home...
March 2016: Social Science & Medicine
https://www.readbyqxmd.com/read/26666677/radiographic-correction-following-reconstruction-of-adult-acquired-flat-foot-deformity-using-the-cotton-medial-cuneiform-osteotomy
#8
Amiethab Aiyer, Graham F Dall, Jeffrey Shub, Mark S Myerson
BACKGROUND: The Cotton osteotomy has been used to correct residual forefoot supination in flexible flatfoot deformity reconstruction. The purpose of this study was to delineate the radiographic effects of the Cotton osteotomy by controlling for concomitant procedures used for deformity correction. METHODS: We retrospectively analyzed 67 patients who underwent a Cotton osteotomy as part of a flatfoot reconstructive procedure. We evaluated 12 radiographic parameters including the articular surface angles of the foot, Meary angle, and a newly defined medial arch sag angle (MASA)...
May 2016: Foot & Ankle International
https://www.readbyqxmd.com/read/26129877/functional-characterization-of-rare-variants-implicated-in-susceptibility-to-lone-atrial-fibrillation
#9
Kenshi Hayashi, Tetsuo Konno, Hayato Tada, Satoyuki Tani, Li Liu, Noboru Fujino, Atsushi Nohara, Akihiko Hodatsu, Toyonobu Tsuda, Yoshihiro Tanaka, Masa-aki Kawashiri, Hidekazu Ino, Naomasa Makita, Masakazu Yamagishi
BACKGROUND: Few rare variants in atrial fibrillation (AF)-associated genes have been functionally characterized to identify a causal relationship between these variants and development of AF. We here sought to determine the clinical effect of rare variants in AF-associated genes in patients with lone AF and characterized these variants electrophysiologically and bioinformatically. METHODS AND RESULTS: We screened all coding regions in 12 AF-associated genes in 90 patients with lone AF, with an onset of 47±11 years (66 men; mean age, 56±13 years) by high-resolution melting curve analysis and DNA sequencing...
October 2015: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/26052280/segmental-bayesian-estimation-of-gap-junctional-and-inhibitory-conductance-of-inferior-olive-neurons-from-spike-trains-with-complicated-dynamics
#10
Huu Hoang, Okito Yamashita, Isao T Tokuda, Masa-Aki Sato, Mitsuo Kawato, Keisuke Toyama
The inverse problem for estimating model parameters from brain spike data is an ill-posed problem because of a huge mismatch in the system complexity between the model and the brain as well as its non-stationary dynamics, and needs a stochastic approach that finds the most likely solution among many possible solutions. In the present study, we developed a segmental Bayesian method to estimate the two parameters of interest, the gap-junctional (gc ) and inhibitory conductance (gi ) from inferior olive spike data...
2015: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/25991858/avian-sarcoma-leukosis-virus-receptor-envelope-system-for-simultaneous-dissection-of-multiple-neural-circuits-in-mammalian-brain
#11
Makoto Matsuyama, Yohei Ohashi, Tadashi Tsubota, Masae Yaguchi, Shigeki Kato, Kazuto Kobayashi, Yasushi Miyashita
Pathway-specific gene delivery is requisite for understanding complex neuronal systems in which neurons that project to different target regions are locally intermingled. However, conventional genetic tools cannot achieve simultaneous, independent gene delivery into multiple target cells with high efficiency and low cross-reactivity. In this study, we systematically screened all receptor-envelope pairs resulting from the combination of four avian sarcoma leukosis virus (ASLV) envelopes (EnvA, EnvB, EnvC, and EnvE) and five engineered avian-derived receptors (TVA950, TVB(S3), TVC, TVB(T), and DR-46TVB) in vitro...
June 2, 2015: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/25985062/utility-of-the-japanese-version-of-the-9-item-wearing-off-questionnaire
#12
Jiro Fukae, Masa-aki Higuchi, Shosaburo Yanamoto, Kosuke Fukuhara, Jun Tsugawa, Shinji Ouma, Taku Hatano, Asako Yoritaka, Yasuyuki Okuma, Kenichi Kashihara, Nobutaka Hattori, Yoshio Tsuboi
BACKGROUND AND PURPOSE: The 9-item Wearing-off Questionnaire (WOQ-9) is a useful tool for screening of wearing-off. We performed a validation study of the Japanese version of the WOQ-9 (JWOQ-9) using a cross-sectional design in Japanese Parkinson's disease (PD) patients diagnosed with sporadic PD and treated with levodopa. METHODS: Subjects with severe dementia, uncontrolled psychiatric comorbidities, and previous PD neurosurgery were excluded. The wearing-off phenomenon was detected according to the JWOQ-9, and the results were compared with independent evaluations of wearing-off conducted by PD specialists blinded to the JWOQ-9 results...
July 2015: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/25947667/modified-adherence-method-mam-for-electrofusion-of-anchorage-dependent-cells
#13
Marko Ušaj, Maša Kandušer
The artificially induced cell fusion is a useful experimental tool in biology, biotechnology and medicine. The electrofusion is a physical method for cell fusion that applies high-voltage electric pulses. The use of electric pulses causes cell membrane structural changes which bring the cell membrane in the so-called fusogenic state. When such fusogenic membranes are in close contact cell fusion takes place. Physical contact between fusion partners can be achieved by various methods and one of them is modified adherence method (MAM) described in detail here on B16-F1 cell line...
2015: Methods in Molecular Biology
https://www.readbyqxmd.com/read/25849775/structural-basis-for-na-transport-mechanism-by-a-light-driven-na-pump
#14
Hideaki E Kato, Keiichi Inoue, Rei Abe-Yoshizumi, Yoshitaka Kato, Hikaru Ono, Masae Konno, Shoko Hososhima, Toru Ishizuka, Mohammad Razuanul Hoque, Hirofumi Kunitomo, Jumpei Ito, Susumu Yoshizawa, Keitaro Yamashita, Mizuki Takemoto, Tomohiro Nishizawa, Reiya Taniguchi, Kazuhiro Kogure, Andrés D Maturana, Yuichi Iino, Hiromu Yawo, Ryuichiro Ishitani, Hideki Kandori, Osamu Nureki
Krokinobacter eikastus rhodopsin 2 (KR2) is the first light-driven Na(+) pump discovered, and is viewed as a potential next-generation optogenetics tool. Since the positively charged Schiff base proton, located within the ion-conducting pathway of all light-driven ion pumps, was thought to prohibit the transport of a non-proton cation, the discovery of KR2 raised the question of how it achieves Na(+) transport. Here we present crystal structures of KR2 under neutral and acidic conditions, which represent the resting and M-like intermediate states, respectively...
May 7, 2015: Nature
https://www.readbyqxmd.com/read/25711216/publishing-integrity-and-good-practices-in-editing-in-biomedicine
#15
Momir Polenakovic, Zoran Gucev
The Macedonian Academy of Sciences and Arts (MASA), held a scientific workshop for journal editors in biomedicine: "Publishing integrity and good practices in editing in biomedicine" on April 25, 2014 in MASA, Skopje. The meeting looked into old problems and new situations in editing and publishing, with emphasis on the situation in developing countries. This global knowledge-based society is founded on the results obtained from scientific research. The data from basic research in developed countries contribute in a quite substantial manner to the newly added economic value...
2014: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/25634284/yeast-as-a-tool-to-study-mitochondrial-retrograde-pathway-en-route-to-cell-stress-response
#16
Maša Ždralević, Nicoletta Guaragnella, Sergio Giannattasio
Mitochondrial retrograde signaling is a mitochondria-to-nucleus communication pathway, conserved from yeast to humans, by which dysfunctional mitochondria relay signals that lead to cell stress adaptation in physiopathological conditions by changes in nuclear gene expression. The best comprehension of components and regulation of retrograde signaling have been obtained in Saccharomyces cerevisiae, where retrograde target gene expression is regulated by RTG genes. In this chapter, we describe the methods to measure mitochondrial retrograde pathway activation in yeast cells by monitoring the mRNA levels of RTG target genes, such as those encoding for peroxisomal citrate synthase, aconitase, and NAD(+)-specific isocitrate dehydrogenase subunit 1, as well as the phosphorylation status of Rtg1/3p transcriptional factor which controls RTG target gene transcription...
2015: Methods in Molecular Biology
https://www.readbyqxmd.com/read/25632026/exome-sequencing-in-suspected-monogenic-dyslipidemias
#17
Nathan O Stitziel, Gina M Peloso, Marianne Abifadel, Angelo B Cefalu, Sigrid Fouchier, M Mahdi Motazacker, Hayato Tada, Daniel B Larach, Zuhier Awan, Jorge F Haller, Clive R Pullinger, Mathilde Varret, Jean-Pierre Rabès, Davide Noto, Patrizia Tarugi, Masa-Aki Kawashiri, Atsushi Nohara, Masakazu Yamagishi, Marjorie Risman, Rahul Deo, Isabelle Ruel, Jay Shendure, Deborah A Nickerson, James G Wilson, Stephen S Rich, Namrata Gupta, Deborah N Farlow, Benjamin M Neale, Mark J Daly, John P Kane, Mason W Freeman, Jacques Genest, Daniel J Rader, Hiroshi Mabuchi, John J P Kastelein, G Kees Hovingh, Maurizio R Averna, Stacey Gabriel, Catherine Boileau, Sekar Kathiresan
BACKGROUND: Exome sequencing is a promising tool for gene mapping in Mendelian disorders. We used this technique in an attempt to identify novel genes underlying monogenic dyslipidemias. METHODS AND RESULTS: We performed exome sequencing on 213 selected family members from 41 kindreds with suspected Mendelian inheritance of extreme levels of low-density lipoprotein cholesterol (after candidate gene sequencing excluded known genetic causes for high low-density lipoprotein cholesterol families) or high-density lipoprotein cholesterol...
April 2015: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/25481238/good-mates-retain-us-right-investigating-the-relationship-between-mate-retention-strategies-mate-value-and-relationship-satisfaction
#18
Svjetlana Salkicevic, Ajana L Stanic, Masa T Grabovac
Mate retention strategies are an important tool in keeping a partner, and their use is determined by the mate value (MV) of the partner one is trying to keep. The type of strategy used is also dependent on one's own MV: mates of lower MV are more prone to exhibiting strategies that are cost-inflicting for their partners, whereas partner-benefiting strategies are used by mates of higher value. The type of strategies used affects relationship satisfaction (RS), and is also affected by the perceived difference in MVs...
2014: Evolutionary Psychology: An International Journal of Evolutionary Approaches to Psychology and Behavior
https://www.readbyqxmd.com/read/25457695/-intraobserver-reliability-and-internal-consistency-of-the-behavioral-pain-scale-in-mechanically-ventilated-patients
#19
M Navarro-Colom, M A Sendra-Lluis, A M Castillo-Masa, G Robleda
BACKGROUND: The Behavioral Pain Scale (BPS) is a tool of pain assessment that often gives contradictory results when used by different raters. OBJECTIVE: To assess internal consistency and interrater reliability of BPS scale in the pain assessment performed by intensives care nurses. METHODS: A prospective observational study in 34 mechanically-ventilated patients, carried out in an Intensive Care Unit from April to June 2012. Variables analyzed included demographic characteristics, diagnosis of referral, clinical status, pain and sedation level...
January 2015: Enfermería Intensiva
https://www.readbyqxmd.com/read/25431514/hiv-risk-among-young-ghanaians-in-high-school-validation-of-a-multidimensional-attitude-towards-condom-use-scale
#20
Rainier D Masa, Gina A Chowa
Condom use remains low among sexually active youth in sub-Saharan Africa. Theoretical and empirical evidence suggests that attitudes towards condom use are important predictors of actual condom use. However, few attempts have been made to systematically develop a valid scale that measures attitudes towards condom use among youth, particularly high school students in sub-Saharan Africa. Using the health belief model, we developed an instrument that measures such attitudes. We analysed survey data collected from 6252 Ghanaian junior high school students...
October 2, 2014: International Journal of Adolescence and Youth
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