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https://www.readbyqxmd.com/read/29859376/mcaw-db-a-glycan-profile-database-capturing-the-ambiguity-of-glycan-recognition-patterns
#1
Masae Hosoda, Yushi Takahashi, Masaaki Shiota, Daisuke Shinmachi, Renji Inomoto, Shinichi Higashimoto, Kiyoko F Aoki-Kinoshita
Glycan-binding protein (GBP) interaction experiments, such as glycan microarrays, are often used to understand glycan recognition patterns. However, oftentimes the interpretation of glycan array experimental data makes it difficult to identify discrete GBP binding patterns due to their ambiguity. It is known that lectins, for example, are non-specific in their binding affinities; the same lectin can bind to different monosaccharides or even different glycan structures. In bioinformatics, several tools to mine the data generated from these sorts of experiments have been developed...
May 11, 2018: Carbohydrate Research
https://www.readbyqxmd.com/read/29733063/adrenergic-signaling-molecular-complexes
#2
Rocío Alcántara-Hernández, Aurelio Hernández-Méndez
Adrenaline and noradrenaline bind to membrane receptors of the superfamily of G protein-coupled receptors (GPCR) in target cells, where they modulate physiological responses such as metabolism, vasoconstriction, vasodilation and proliferation. Alteration in their function is associated with conditions such as hypertension, benign prostatic hyperplasia and cardiac hypertrophy. In response to adrenaline, receptors form signaling complexes, which enables adrenergic action to be specific, rapid and efficient. These signaling complexes or signalosomes are composed of kinases, phosphatases, and adapter and scaffold proteins, which together modulate the receptor function...
2018: Gaceta Médica de México
https://www.readbyqxmd.com/read/29719626/identification-of-specific-and-common-diagnostic-antibody-markers-for-gastrointestinal-cancers-by-serex-screening-using-testis-cdna-phage-library
#3
Sohei Kobayashi, Takaki Hiwasa, Takahiro Arasawa, Akiko Kagaya, Sayaka Ishii, Hideaki Shimada, Masaaki Ito, Masae Suzuki, Masayuki Kano, Bahityar Rahmutulla, Kouichi Kitamura, Yuji Sawabe, Hideo Shin, Masaki Takiguchi, Fumio Nomura, Hisahiro Matsubara, Kazuyuki Matsushita
The present study was planned to identify novel serum antibody markers for digestive organ cancers. We have used screening by phage expression cloning and identified novel fourteen antigens in this experiment. The presence of auto-antibodies against these antigens in serum specimens was confirmed by western blotting. As for auto-antibodies against fourteen antigens, AlphaLISA (amplified luminescence proximity homogeneous assay) assay was performed in the sera of gastrointestinal cancers patients to confirm the results...
April 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29571756/a-validated-swallow-screener-for-dysphagia-and-aspiration-in-patients-with-stroke
#4
Anit Behera, Dana Read, Nancy Jackson, Bashar Saour, Dana Alshekhlee, Amy K Mosier
BACKGROUND: Early detection of dysphagia is critical to reducing hospital complications and length of stay in patients with various types of strokes. The aim of this study was to develop and evaluate the DePaul Hospital Swallow Screener (DHSS) tool to assess for dysphagia in patients with stroke. METHODS: This prospective observational study investigated patients admitted to a comprehensive stroke center. The DHSS is composed of a questionnaire containing 8 nonswallow items and a water swallow test...
March 20, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29407077/development-and-external-validation-of-a-post-discharge-bleeding-risk-score-in-patients-with-acute-coronary-syndrome-the-bleemacs-score
#5
Sergio Raposeiras-Roubín, Jonas Faxén, Andrés Íñiguez-Romo, Jose Paulo Simao Henriques, Fabrizio D'Ascenzo, Jorge Saucedo, Karolina Szummer, Tomas Jernberg, Stefan K James, José Ramón González Juanatey, Stephen B Wilton, Wouter J Kikkert, Iván Nuñez-Gil, Albert Ariza-Sole, Xiantao Song, Dimitrios Alexopoulos, Christoph Liebetrau, Tetsuma Kawaji, Claudio Moretti, Zenon Huczek, Shao-Ping Nie, Toshiharu Fujii, Luis Correia, Masa-Aki Kawashiri, Berenice Caneiro-Queija, Rafael Cobas-Paz, José María García Acuña, Danielle Southern, Emilio Alfonso, Belén Terol, Alberto Garay, Dongfeng Zhang, Yalei Chen, Ioanna Xanthopoulou, Neriman Osman, Helge Möllmann, Hiroki Shiomi, Francesca Giordana, Fiorenzo Gaita, Michal Kowara, Krzysztof Filipiak, Xiao Wang, Yan Yan, Jing-Yao Fan, Yuji Ikari, Takuya Nakahayshi, Kenji Sakata, Masakazu Yamagishi, Oliver Kalpak, Sasko Kedev, Daniel Rivera-Asenjo, Emad Abu-Assi
BACKGROUND: Accurate 1-year bleeding risk estimation after hospital discharge for acute coronary syndrome (ACS) may help clinicians guide the type and duration of antithrombotic therapy. Currently there are no predictive models for this purpose. The aim of this study was to derive and validate a simple clinical tool for bedside risk estimation of 1-year post-discharge serious bleeding in ACS patients. METHODS: The risk score was derived and internally validated in the BleeMACS (Bleeding complications in a Multicenter registry of patients discharged with diagnosis of Acute Coronary Syndrome) registry, an observational international registry involving 15,401 patients surviving admission for ACS and undergoing percutaneous coronary intervention (PCI) from 2003 to 2014, engaging 15 hospitals from 10 countries located in America, Europe and Asia...
March 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29259480/efficacy-of-the-endometrial-receptivity-array-for-repeated-implantation-failure-in-japan-a-retrospective-two-centers-study
#6
Tomoko Hashimoto, Masae Koizumi, Masakazu Doshida, Mayumi Toya, Eri Sagara, Nao Oka, Yukiko Nakajo, Nobuya Aono, Hideki Igarashi, Koichi Kyono
Aim: This study aimed to assess the efficacy of the endometrial receptivity array (ERA) as a diagnostic tool and the impact of personalized embryo transfer (pET) for the treatment of patients with recurrent implantation failure (RIF) in Japan. Methods: Fifty patients with a history of RIF with frozen-thawed blastocyst transfers were recruited from July, 2015 to April, 2016. Endometrial sampling for the ERA and histological dating and a pET according to the ERA were performed...
July 2017: Reproductive Medicine and Biology
https://www.readbyqxmd.com/read/29125995/a-human-ips-cell-myogenic-differentiation-system-permitting-high-throughput-drug-screening
#7
Tomoya Uchimura, Jun Otomo, Masae Sato, Hidetoshi Sakurai
Muscular dystrophy is a disease characterized by progressive muscle weakness and degeneration. There are currently no available treatments for most muscular diseases, such as muscular dystrophy. Moreover, current therapeutics are focused on improving the quality of life of patients by relieving the symptoms or stress caused by the disease. Although the causative genes for many muscular diseases have been identified, the mechanisms underlying their pathogenesis remain unclear. Patient-derived induced pluripotent stem cells (iPSCs) have become a powerful tool for understanding the pathogenesis of intractable diseases, as well as for phenotype screening, which can serve as the basis for developing new drugs...
December 2017: Stem Cell Research
https://www.readbyqxmd.com/read/29111135/digital-gene-atlas-of-neonate-common-marmoset-brain
#8
Tomomi Shimogori, Ayumi Abe, Yasuhiro Go, Tsutomu Hashikawa, Noriyuki Kishi, Satomi S Kikuchi, Yoshiaki Kita, Kimie Niimi, Hirozumi Nishibe, Misako Okuno, Kanako Saga, Miyano Sakurai, Masae Sato, Tsuna Serizawa, Sachie Suzuki, Eiki Takahashi, Mami Tanaka, Shoji Tatsumoto, Mitsuhiro Toki, Mami U, Yan Wang, Karl J Windak, Haruhiko Yamagishi, Keiko Yamashita, Tomoko Yoda, Aya C Yoshida, Chihiro Yoshida, Takuro Yoshimoto, Hideyuki Okano
Interest in the common marmoset (Callithrix jacchus) as a primate model animal has grown recently, in part due to the successful demonstration of transgenic marmosets. However, there is some debate as to the suitability of marmosets, compared to more widely used animal models, such as the macaque monkey and mouse. Especially, the usage of marmoset for animal models of human cognition and mental disorders, is still yet to be fully explored. To examine the prospects of the marmoset model for neuroscience research, the Marmoset Gene Atlas (https://gene-atlas...
March 2018: Neuroscience Research
https://www.readbyqxmd.com/read/28944587/finding-the-genetic-mechanisms-of-folate-deficiency-and-neural-tube-defects-leaving-no-stone-unturned
#9
REVIEW
Kit Sing Au, Tina O Findley, Hope Northrup
Neural tube defects (NTDs) occur secondary to failed closure of the neural tube between the third and fourth weeks of gestation. The worldwide incidence ranges from 0.3 to 200 per 10,000 births with the United States of American NTD incidence at around 3-6.3 per 10,000 dependent on race and socioeconomic background. Human NTD incidence has fallen by 35-50% in North America due to mandatory folic acid fortification of enriched cereal grain products since 1998. The US Food and Drug Administration has approved the folic acid fortification of corn masa flour with the goal to further reduce the incidence of NTDs, especially among individuals who are Hispanic...
November 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28840057/evaluation-of-the-mann-assessment-of-swallowing-ability-in-elderly-patients-with-pneumonia
#10
Yasuo Chojin, Tatsuji Kato, Mariko Rikihisa, Masami Omori, Shingo Noguchi, Kentaro Akata, Takaaki Ogoshi, Kazuhiro Yatera, Hiroshi Mukae
Elderly pneumonia patients have various underlying diseases and social backgrounds, and it is difficult to predict their mortality using the current severity assessment tools. However, aspiration is a risk factor for mortality in pneumonia patients. In the evaluation of aspiration, endoscopic and video fluoroscopic methods are reliable but cannot be performed in all pneumonia patients. We evaluated the significance of the Mann Assessment of Swallowing Ability (MASA) in these patients. This study was prospectively performed between December 2014 and June 2015, and all adult hospitalized patients with pneumonia were consecutively enrolled...
July 2017: Aging and Disease
https://www.readbyqxmd.com/read/28601120/measurement-of-breath-ammonia-for-detection-of-patients-with-chronic-kidney-disease
#11
Sebastjan Bevc, Eva Mohorko, Mitja Kolar, Polona Brglez, Andrej Holobar, Daniela Kniepeiss, Matej Podbregar, Nejc Piko, Nina Hojs, Maša Knehtl, Robert Ekart, Radovan Hojs
BACKGROUND: In a healthy individual, ammonia is converted to urea in the liver. Urea is then transported through the bloodstream and then excreted into the urine by the kidneys. In patients with chronic kidney disease (CKD), the accumulated urea is degraded by salivary urease into ammonia, which is then excreted by breathing. Breath ammonia can therefore be used for detecting the increased nitrogen-bearing wastes. In our pilot study, an electrochemical sensor was used to measure and analyze breath ammonia in healthy volunteers and patients with CKD...
2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28374867/dysphagia-screening-in-subacute-care-settings-using-the-italian-version-of-the-royal-brisbane-and-women-s-hospital-i-rbwh-dysphagia-screening-tool
#12
F Mozzanica, L Scarponi, S Pedrali, N Pizzorni, C Pinotti, F Foieni, G Zuccotti, A Schindler
The large majority of the available dysphagia screening tools has been developed for the stroke population. Only few screening tools are suitable for heterogeneous groups of patients admitted to a subacute care unit. The Royal Brisbane and Women's Hospital (RBWH) dysphagia screening tool is a nurse-administered, evidence-based swallow screening tool for generic acute hospital use that demonstrates excellent sensitivity and specificity. No Italian version of this tool is available to date. The aim of this study was to determine the reliability and screening accuracy of the Italian version of the RBWH (I-RBWH) dysphagia screening tool...
February 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28357930/quality-reporting-of-carotid-intima-media-thickness-methodology-current-state-of-the-science-in-the-field-of-spinal-cord-injury
#13
Jordan D Hoskin, Masae Miyatani, B Catharine Craven
OBJECTIVES: Carotid intima-media thickness (cIMT) may be used increasingly as a cardiovascular disease (CVD) screening tool in individuals with spinal cord injury (SCI) as other routine invasive diagnostic tests are often unfeasible. However, variation in cIMT acquisition and analysis methods is an issue in the current published literature. The growth of the field is dependent on cIMT quality acquisition and analysis to ensure accurate reporting of CVD risk. The purpose of this study is to evaluate the quality of the reported methodology used to collect cIMT values in SCI...
March 30, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28247010/pathological-and-molecular-analyses-of-atherosclerotic-lesions-in-apoe-knockout-mice
#14
Masa-Aki Shibata, Eiko Shibata, Kentaro Maemura, Yoichi Kondo, Mariko Harada-Shiba
The establishment of consistent and reliable methods for the analysis of atherosclerosis molecular pathways and for testing the efficiency of new therapeutics is of utmost importance. Here, we fed ApoE-knockout (KO) mice with high-fat diet to for 16 weeks to induce atherosclerosis. Atherosclerotic lesions in mice were methodically investigated using pathologic analyses and molecular biology tools. These lesions were histopathologically classified into three categories: early, progressive, and combined lesions...
September 2017: Medical Molecular Morphology
https://www.readbyqxmd.com/read/28093404/development-and-application-of-an-algorithm-to-compute-weighted-multiple-glycan-alignments
#15
Masae Hosoda, Yukie Akune, Kiyoko F Aoki-Kinoshita
Motivation: A glycan consists of monosaccharides linked by glycosidic bonds, has branches and forms complex molecular structures. Databases have been developed to store large amounts of glycan-binding experiments, including glycan arrays with glycan-binding proteins. However, there are few bioinformatics techniques to analyze large amounts of data for glycans because there are few tools that can handle the complexity of glycan structures. Thus, we have developed the MCAW (Multiple Carbohydrate Alignment with Weights) tool that can align multiple glycan structures, to aid in the understanding of their function as binding recognition molecules...
May 1, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28053973/noninvasive-ventilation-during-the-weaning-process-in-chronically-critically-ill-patients
#16
Jesus Sancho, Emilio Servera, Luis Jara-Palomares, Emilia Barrot, Raquel Sanchez-Oro-Gómez, F Javier Gómez de Terreros, M Jesús Martín-Vicente, Isabel Utrabo, M Belen Núñez, Alicia Binimelis, Ernest Sala, Enrique Zamora, Gonzalo Segrelles, Angel Ortega-Gonzalez, Fernando Masa
Chronically critically ill patients often undergo prolonged mechanical ventilation. The role of noninvasive ventilation (NIV) during weaning of these patients remains unclear. The aim of this study was to determine the value of NIV and whether a parameter can predict the need for NIV in chronically critically ill patients during the weaning process. We conducted a prospective study that included chronically critically ill patients admitted to Spanish respiratory care units. The weaning method used consisted of progressive periods of spontaneous breathing trials...
October 2016: ERJ Open Research
https://www.readbyqxmd.com/read/27904591/brain-regions-involved-in-swallowing-evidence-from-stroke-patients-in-a-cross-sectional-study
#17
Shiva Ebrahimian Dehaghani, Fariba Yadegari, Ali Asgari, Ahmad Chitsaz, Mehdi Karami
BACKGROUND: Limited data available about the mechanisms of dysphagia and areas involving swallow after brain damage; accordingly it is hard to predict which cases are more likely to develop swallowing dysfunction based on the neuroimaging. The aim of this study was to investigate the relationship between brain lesions and dysphagia in a sample of acute conscious stroke patients. MATERIALS AND METHODS: In a cross-sectional study, 113 acute conscious stroke patients (69 male mean [standard deviation (SD)] age 64...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27755873/hydrogen-bonding-induced-fluorescence-water-soluble-and-polarity-independent-solvatochromic-fluorophores
#18
Yohei Okada, Masae Sugai, Kazuhiro Chiba
Fluorophores with emission wavelengths that shift depending on their hydrogen-bonding microenvironment in water would be fascinating tools for the study of biological events. Herein we describe the design and synthesis of a series of water-soluble solvatochromic fluorophores, 2,5-bis(oligoethylene glycol)oxybenzaldehydes (8-11) and 2,5-bis(oligoethylene glycol)oxy-1,4-dibenzaldehydes (14-17), based on a push-pull strategy. Unlike typical examples in this class of fluorophores, the fluorescence properties of these compounds are independent of solvent polarity and become fluorescent upon intermolecular hydrogen-bonding, exhibiting high quantum yields (up to ϕ = 0...
November 18, 2016: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/27598377/sociodemographic-factors-and-health-conditions-associated-with-the-resilience-of-people-with-chronic-diseases-a-cross-sectional-study
#19
Julia Estela Willrich Böell, Denise Maria Guerreiro Vieira da Silva, Kathleen Mary Hegadoren
OBJECTIVE: to investigate the association between resilience and sociodemographic variables and the health of people with chronic kidney disease and / or type 2 diabetes mellitus. METHOD: a cross-sectional observational study performed with 603 people with chronic kidney disease and / or type 2 diabetes mellitus. A tool to collect socio-demographic and health data and the Resilience Scale developed by Connor and Davidson were applied. A descriptive and multivariate analysis was performed...
September 1, 2016: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/27512702/validity-reliability-and-factor-analysis-of-persian-version-of-schizophrenia-quality-of-life-scale
#20
Nasrin Masaeli, Victoria Omranifard, Mohammad Reza Maracy, Gholam Reza Kheirabadi, Anahita Khedri
CONTEXT: Exact measurement of quality of life (QOL) in schizophrenia patients for evaluation of the patient's deterioration and also to assess the efficacy of therapeutic Interventions has become a daily task, which requires accurate assessment tools. AIMS: This study was aimed to assess the psychometric properties of a Persian version of schizophrenia QOL scale (SQLS) as a common transcultural instrument. SETTINGS AND DESIGN: One hundred and fifty schizophrenia patients who referred to Psychiatric Clinic in Noor Hospital (Isfahan, Iran) have been selected using simple sampling method...
2016: Journal of Education and Health Promotion
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