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MASA tool

F Mozzanica, L Scarponi, S Pedrali, N Pizzorni, C Pinotti, F Foieni, G Zuccotti, A Schindler
The large majority of the available dysphagia screening tools has been developed for the stroke population. Only few screening tools are suitable for heterogeneous groups of patients admitted to a subacute care unit. The Royal Brisbane and Women's Hospital (RBWH) dysphagia screening tool is a nurse-administered, evidence-based swallow screening tool for generic acute hospital use that demonstrates excellent sensitivity and specificity. No Italian version of this tool is available to date. The aim of this study was to determine the reliability and screening accuracy of the Italian version of the RBWH (I-RBWH) dysphagia screening tool...
February 2017: Acta Otorhinolaryngologica Italica
Jordan D Hoskin, Masae Miyatani, B Catharine Craven
OBJECTIVES: Carotid intima-media thickness (cIMT) may be used increasingly as a cardiovascular disease (CVD) screening tool in individuals with spinal cord injury (SCI) as other routine invasive diagnostic tests are often unfeasible. However, variation in cIMT acquisition and analysis methods is an issue in the current published literature. The growth of the field is dependent on cIMT quality acquisition and analysis to ensure accurate reporting of CVD risk. The purpose of this study is to evaluate the quality of the reported methodology used to collect cIMT values in SCI...
March 30, 2017: Journal of Spinal Cord Medicine
Masa-Aki Shibata, Eiko Shibata, Kentaro Maemura, Yoichi Kondo, Mariko Harada-Shiba
The establishment of consistent and reliable methods for the analysis of atherosclerosis molecular pathways and for testing the efficiency of new therapeutics is of utmost importance. Here, we fed ApoE-knockout (KO) mice with high-fat diet to for 16 weeks to induce atherosclerosis. Atherosclerotic lesions in mice were methodically investigated using pathologic analyses and molecular biology tools. These lesions were histopathologically classified into three categories: early, progressive, and combined lesions...
February 28, 2017: Medical Molecular Morphology
Masae Hosoda, Yukie Akune, Kiyoko F Aoki-Kinoshita
MOTIVATION: A glycan consists of monosaccharides linked by glycosidic bonds, has branches and forms complex molecular structures. Databases have been developed to store large amounts of glycan-binding experiments, including glycan arrays with glycan binding proteins (GBPs). However, there are few bioinformatics techniques to analyze large amounts of data for glycans because there are few tools that can handle the complexity of glycan structures. Thus, we have developed the MCAW (Multiple Carbohydrate Alignment with Weights) tool that can align multiple glycan structures, to aid in the understanding of their function as binding recognition molecules...
January 16, 2017: Bioinformatics
Jesus Sancho, Emilio Servera, Luis Jara-Palomares, Emilia Barrot, Raquel Sanchez-Oro-Gómez, F Javier Gómez de Terreros, M Jesús Martín-Vicente, Isabel Utrabo, M Belen Núñez, Alicia Binimelis, Ernest Sala, Enrique Zamora, Gonzalo Segrelles, Angel Ortega-Gonzalez, Fernando Masa
Chronically critically ill patients often undergo prolonged mechanical ventilation. The role of noninvasive ventilation (NIV) during weaning of these patients remains unclear. The aim of this study was to determine the value of NIV and whether a parameter can predict the need for NIV in chronically critically ill patients during the weaning process. We conducted a prospective study that included chronically critically ill patients admitted to Spanish respiratory care units. The weaning method used consisted of progressive periods of spontaneous breathing trials...
October 2016: ERJ Open Research
Shiva Ebrahimian Dehaghani, Fariba Yadegari, Ali Asgari, Ahmad Chitsaz, Mehdi Karami
BACKGROUND: Limited data available about the mechanisms of dysphagia and areas involving swallow after brain damage; accordingly it is hard to predict which cases are more likely to develop swallowing dysfunction based on the neuroimaging. The aim of this study was to investigate the relationship between brain lesions and dysphagia in a sample of acute conscious stroke patients. MATERIALS AND METHODS: In a cross-sectional study, 113 acute conscious stroke patients (69 male mean [standard deviation (SD)] age 64...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
Yohei Okada, Masae Sugai, Kazuhiro Chiba
Fluorophores with emission wavelengths that shift depending on their hydrogen-bonding microenvironment in water would be fascinating tools for the study of biological events. Herein we describe the design and synthesis of a series of water-soluble solvatochromic fluorophores, 2,5-bis(oligoethylene glycol)oxybenzaldehydes (8-11) and 2,5-bis(oligoethylene glycol)oxy-1,4-dibenzaldehydes (14-17), based on a push-pull strategy. Unlike typical examples in this class of fluorophores, the fluorescence properties of these compounds are independent of solvent polarity and become fluorescent upon intermolecular hydrogen-bonding, exhibiting high quantum yields (up to ϕ = 0...
November 18, 2016: Journal of Organic Chemistry
Julia Estela Willrich Böell, Denise Maria Guerreiro Vieira da Silva, Kathleen Mary Hegadoren
OBJECTIVE: to investigate the association between resilience and sociodemographic variables and the health of people with chronic kidney disease and / or type 2 diabetes mellitus. METHOD: a cross-sectional observational study performed with 603 people with chronic kidney disease and / or type 2 diabetes mellitus. A tool to collect socio-demographic and health data and the Resilience Scale developed by Connor and Davidson were applied. A descriptive and multivariate analysis was performed...
September 1, 2016: Revista Latino-americana de Enfermagem
Nasrin Masaeli, Victoria Omranifard, Mohammad Reza Maracy, Gholam Reza Kheirabadi, Anahita Khedri
CONTEXT: Exact measurement of quality of life (QOL) in schizophrenia patients for evaluation of the patient's deterioration and also to assess the efficacy of therapeutic Interventions has become a daily task, which requires accurate assessment tools. AIMS: This study was aimed to assess the psychometric properties of a Persian version of schizophrenia QOL scale (SQLS) as a common transcultural instrument. SETTINGS AND DESIGN: One hundred and fifty schizophrenia patients who referred to Psychiatric Clinic in Noor Hospital (Isfahan, Iran) have been selected using simple sampling method...
2016: Journal of Education and Health Promotion
Mariko Ohira, Ryo Ishida, Yoshinobu Maki, Mai Ohkubo, Tetsuya Sugiyama, Takaharu Sakayori, Toru Sato
AIM: Dysphagia is common in dependent older adults. Thus, a method of evaluating eating and swallowing functions that can be used to diagnose and manage dysphagia in a simple and robust manner is required. In 2002, the Mann Assessment of Swallowing Ability (MASA) was introduced to identify dysphagia in acute-stage stroke patients. As the MASA enables easy screening, it might also be applicable to dependent older adults if appropriate MASA cut-off values and the most useful assessment items could be determined...
May 16, 2016: Geriatrics & Gerontology International
Hayato Tada, Masa-Aki Kawashiri, Hirofumi Okada, Saori Endo, Yuka Toyoshima, Tetsuo Konno, Atsushi Nohara, Akihiro Inazu, Akira Takao, Hiroshi Mabuchi, Masakazu Yamagishi, Kenshi Hayashi
Whole exome sequencing (WES) technologies have accelerated genetic studies of Mendelian disorders, yielding approximately 30% diagnostic success. We encountered a 13-year-old Japanese female initially diagnosed with familial hypercholesterolemia on the basis of clinical manifestations of severe hypercholesterolemia (initial LDL cholesterol=609 mg/dl at the age of one) and systemic intertriginous xanthomas with histories of recurrent self-limiting episodes of fever and arthritis. Both her phenotypes seemed to co-segregate in a recessive manner...
July 1, 2016: Journal of Atherosclerosis and Thrombosis
Margaret Sleeboom-Faulkner, Choon Key Chekar, Alex Faulkner, Carolyn Heitmeyer, Marina Marouda, Achim Rosemann, Nattaka Chaisinthop, Hung-Chieh Jessica Chang, Adrian Ely, Masae Kato, Prasanna K Patra, Yeyang Su, Suli Sui, Wakana Suzuki, Xinqing Zhang
A very large grey area exists between translational stem cell research and applications that comply with the ideals of randomised control trials and good laboratory and clinical practice and what is often referred to as snake-oil trade. We identify a discrepancy between international research and ethics regulation and the ways in which regulatory instruments in the stem cell field are developed in practice. We examine this discrepancy using the notion of 'national home-keeping', referring to the way governments articulate international standards and regulation with conflicting demands on local players at home...
March 2016: Social Science & Medicine
Amiethab Aiyer, Graham F Dall, Jeffrey Shub, Mark S Myerson
BACKGROUND: The Cotton osteotomy has been used to correct residual forefoot supination in flexible flatfoot deformity reconstruction. The purpose of this study was to delineate the radiographic effects of the Cotton osteotomy by controlling for concomitant procedures used for deformity correction. METHODS: We retrospectively analyzed 67 patients who underwent a Cotton osteotomy as part of a flatfoot reconstructive procedure. We evaluated 12 radiographic parameters including the articular surface angles of the foot, Meary angle, and a newly defined medial arch sag angle (MASA)...
May 2016: Foot & Ankle International
Kenshi Hayashi, Tetsuo Konno, Hayato Tada, Satoyuki Tani, Li Liu, Noboru Fujino, Atsushi Nohara, Akihiko Hodatsu, Toyonobu Tsuda, Yoshihiro Tanaka, Masa-aki Kawashiri, Hidekazu Ino, Naomasa Makita, Masakazu Yamagishi
BACKGROUND: Few rare variants in atrial fibrillation (AF)-associated genes have been functionally characterized to identify a causal relationship between these variants and development of AF. We here sought to determine the clinical effect of rare variants in AF-associated genes in patients with lone AF and characterized these variants electrophysiologically and bioinformatically. METHODS AND RESULTS: We screened all coding regions in 12 AF-associated genes in 90 patients with lone AF, with an onset of 47±11 years (66 men; mean age, 56±13 years) by high-resolution melting curve analysis and DNA sequencing...
October 2015: Circulation. Arrhythmia and Electrophysiology
Huu Hoang, Okito Yamashita, Isao T Tokuda, Masa-Aki Sato, Mitsuo Kawato, Keisuke Toyama
The inverse problem for estimating model parameters from brain spike data is an ill-posed problem because of a huge mismatch in the system complexity between the model and the brain as well as its non-stationary dynamics, and needs a stochastic approach that finds the most likely solution among many possible solutions. In the present study, we developed a segmental Bayesian method to estimate the two parameters of interest, the gap-junctional (gc ) and inhibitory conductance (gi ) from inferior olive spike data...
2015: Frontiers in Computational Neuroscience
Makoto Matsuyama, Yohei Ohashi, Tadashi Tsubota, Masae Yaguchi, Shigeki Kato, Kazuto Kobayashi, Yasushi Miyashita
Pathway-specific gene delivery is requisite for understanding complex neuronal systems in which neurons that project to different target regions are locally intermingled. However, conventional genetic tools cannot achieve simultaneous, independent gene delivery into multiple target cells with high efficiency and low cross-reactivity. In this study, we systematically screened all receptor-envelope pairs resulting from the combination of four avian sarcoma leukosis virus (ASLV) envelopes (EnvA, EnvB, EnvC, and EnvE) and five engineered avian-derived receptors (TVA950, TVB(S3), TVC, TVB(T), and DR-46TVB) in vitro...
June 2, 2015: Proceedings of the National Academy of Sciences of the United States of America
Jiro Fukae, Masa-aki Higuchi, Shosaburo Yanamoto, Kosuke Fukuhara, Jun Tsugawa, Shinji Ouma, Taku Hatano, Asako Yoritaka, Yasuyuki Okuma, Kenichi Kashihara, Nobutaka Hattori, Yoshio Tsuboi
BACKGROUND AND PURPOSE: The 9-item Wearing-off Questionnaire (WOQ-9) is a useful tool for screening of wearing-off. We performed a validation study of the Japanese version of the WOQ-9 (JWOQ-9) using a cross-sectional design in Japanese Parkinson's disease (PD) patients diagnosed with sporadic PD and treated with levodopa. METHODS: Subjects with severe dementia, uncontrolled psychiatric comorbidities, and previous PD neurosurgery were excluded. The wearing-off phenomenon was detected according to the JWOQ-9, and the results were compared with independent evaluations of wearing-off conducted by PD specialists blinded to the JWOQ-9 results...
July 2015: Clinical Neurology and Neurosurgery
Marko Ušaj, Maša Kandušer
The artificially induced cell fusion is a useful experimental tool in biology, biotechnology and medicine. The electrofusion is a physical method for cell fusion that applies high-voltage electric pulses. The use of electric pulses causes cell membrane structural changes which bring the cell membrane in the so-called fusogenic state. When such fusogenic membranes are in close contact cell fusion takes place. Physical contact between fusion partners can be achieved by various methods and one of them is modified adherence method (MAM) described in detail here on B16-F1 cell line...
2015: Methods in Molecular Biology
Hideaki E Kato, Keiichi Inoue, Rei Abe-Yoshizumi, Yoshitaka Kato, Hikaru Ono, Masae Konno, Shoko Hososhima, Toru Ishizuka, Mohammad Razuanul Hoque, Hirofumi Kunitomo, Jumpei Ito, Susumu Yoshizawa, Keitaro Yamashita, Mizuki Takemoto, Tomohiro Nishizawa, Reiya Taniguchi, Kazuhiro Kogure, Andrés D Maturana, Yuichi Iino, Hiromu Yawo, Ryuichiro Ishitani, Hideki Kandori, Osamu Nureki
Krokinobacter eikastus rhodopsin 2 (KR2) is the first light-driven Na(+) pump discovered, and is viewed as a potential next-generation optogenetics tool. Since the positively charged Schiff base proton, located within the ion-conducting pathway of all light-driven ion pumps, was thought to prohibit the transport of a non-proton cation, the discovery of KR2 raised the question of how it achieves Na(+) transport. Here we present crystal structures of KR2 under neutral and acidic conditions, which represent the resting and M-like intermediate states, respectively...
May 7, 2015: Nature
Momir Polenakovic, Zoran Gucev
The Macedonian Academy of Sciences and Arts (MASA), held a scientific workshop for journal editors in biomedicine: "Publishing integrity and good practices in editing in biomedicine" on April 25, 2014 in MASA, Skopje. The meeting looked into old problems and new situations in editing and publishing, with emphasis on the situation in developing countries. This global knowledge-based society is founded on the results obtained from scientific research. The data from basic research in developed countries contribute in a quite substantial manner to the newly added economic value...
2014: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
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