keyword
MENU ▼
Read by QxMD icon Read
search

Biological basis of depress*

keyword
https://www.readbyqxmd.com/read/28237672/interleukin-10-a-compelling-therapeutic-target-in-patients-with-irritable-bowel-syndrome
#1
REVIEW
Sunil Kumar, Ratnakar Shukla, Prabhat Ranjan, Awanish Kumar
PURPOSE: Pro- and antiinflammatory cytokines are important modulators of the immune response and play a major role in conditions of intestinal inflammation, such as irritable bowel syndrome (IBS). Cytokine production is regulated genetically, and imbalances in cytokine secretion may affect disease susceptibility and clinical outcomes of various conditions. There is a rapidly growing body of evidence to support an etiologic role for gastrointestinal infection and the associated immune activation in the development of postinfectious IBS...
February 23, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28236764/the-response-of-isidorella-newcombi-to-copper-exposure-using-an-integrated-biological-framework-to-interpret-transcriptomic-responses-from-rna-seq-analysis
#2
Rodney P Ubrihien, Tariq Ezaz, Anne M Taylor, Mark M Stevens, Frank Krikowa, Simon Foster, William A Maher
This study describes the transcriptomic response of the Australian endemic freshwater gastropod Isidorella newcombi exposed to 80±1μg/L of copper for 3days. Analysis of copper tissue concentration, lysosomal membrane destabilisation and RNA-seq were conducted. Copper tissue concentrations confirmed that copper was bioaccumulated by the snails. Increased lysosomal membrane destabilisation in the copper-exposed snails indicated that the snails were stressed as a result of the exposure. Both copper tissue concentrations and lysosomal destabilisation were significantly greater in snails exposed to copper...
April 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28221057/-understanding-the-neural-basis-of-cognitive-bias-modification-as-a-clinical-treatment-for-depression-correction-to-eguchi-et-al-2016
#3
(no author information available yet)
Reports an error in "Understanding the neural basis of cognitive bias modification as a clinical treatment for depression" by Akihiro Eguchi, Daniel Walters, Nele Peerenboom, Hannah Dury, Elaine Fox and Simon Stringer (Journal of Consulting and Clinical Psychology, Advanced Online Publication, Dec 19, 2016, np). In the article, there was an error in the Discussion section's first paragraph for Implications and Future Work. The in-text reference citation for Penton-Voak et al. (2013) was incorrectly listed as "Blumenfeld, Preminger, Sagi, and Tsodyks (2006)"...
March 2017: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/28203105/association-of-fatigue-and-depression-with-circulating-levels-of-proinflammatory-cytokines-and-epidermal-growth-factor-receptor-ligands-a-correlative-study-of-a-placebo-controlled-fatigue-trial
#4
Tyvin Rich, Fengmin Zhao, Ricardo A Cruciani, David Cella, Judith Manola, Michael J Fisch
CONTEXT: The biology of fatigue and depression in cancer patients is poorly understood. Hypotheses regarding cytokines and growth factors related to sickness behavior and disruption of circadian signaling have been proposed. OBJECTIVES: We prospectively examined proinflammatory cytokines (e.g., sickness behavior model) and epidermal growth factor receptor (EGFR) ligands (e.g., circadian disruption model) in the serum of cancer patients enrolled in a clinical trial testing levocarnitine for fatigue...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/28179814/prenatal-stress-immune-programming-of-sex-differences-in-comorbidity-of-depression-and-obesity-metabolic-syndrome
#5
Jill M Goldstein, Laura Holsen, Grace Huang, Bradley D Hammond, Tamarra James-Todd, Sara Cherkerzian, Taben M Hale, Robert J Handa
Major depressive disorder (MDD) is the number one cause of disability worldwide and is comorbid with many chronic diseases, including obesity/metabolic syndrome (MetS). Women have twice as much risk for MDD and comorbidity with obesity/MetS as men, although pathways for understanding this association remain unclear. On the basis of clinical and preclinical studies, we argue that prenatal maternal stress (ie, excess glucocorticoid expression and associated immune responses) that occurs during the sexual differentiation of the fetal brain has sex-dependent effects on brain development within highly sexually dimorphic regions that regulate mood, stress, metabolic function, the autonomic nervous system, and the vasculature...
December 2016: Dialogues in Clinical Neuroscience
https://www.readbyqxmd.com/read/28149649/hepatitis-c-virus-infection-and-neurological-and-psychiatric-disorders-a-review
#6
REVIEW
Lydia Yarlott, Eleanor Heald, Daniel Forton
An association between hepatitis C virus infection and neuropsychiatric symptoms has been proposed for some years. A variety of studies have been undertaken to assess the nature and severity of these symptoms, which range from fatigue and depression to defects in attention and verbal reasoning. There is evidence of mild neurocognitive impairment in some patients with HCV infection, which is not fully attributable to liver dysfunction or psychosocial factors. Further evidence of a biological cerebral effect has arisen from studies using magnetic resonance spectroscopy; metabolic abnormalities correlate with cognitive dysfunction and resemble the patterns of neuroinflammation that have been described in HIV infection...
March 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/27993607/a-biological-perspective-on-differences-and-similarities-between-burnout-and-depression
#7
REVIEW
Ariane Orosz, Andrea Federspiel, Sarie Haisch, Christian Seeher, Thomas Dierks, Katja Cattapan
To compare and contrast burnout and depression is not only a conceptual issue, but may deliver important directions for treatment approaches and stabilize the awareness of disease which is essential for affected individuals. Because of the symptomatic overlap, it is a subject of multidimensional research and discussion to find specific signatures to differentiate between the two phenomena or to present evidence that they are different aspects of the same disorder. Both pathologies are regarded as stress-related disorders...
February 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27991805/understanding-the-neural-basis-of-cognitive-bias-modification-as-a-clinical-treatment-for-depression
#8
Akihiro Eguchi, Daniel Walters, Nele Peerenboom, Hannah Dury, Elaine Fox, Simon Stringer
[Correction Notice: An Erratum for this article was reported in Vol 85(3) of Journal of Consulting and Clinical Psychology (see record 2017-07144-002). In the article, there was an error in the Discussion section's first paragraph for Implications and Future Work. The in-text reference citation for Penton-Voak et al. (2013) was incorrectly listed as "Blumenfeld, Preminger, Sagi, and Tsodyks (2006)". All versions of this article have been corrected.] Objective: Cognitive bias modification (CBM) eliminates cognitive biases toward negative information and is efficacious in reducing depression recurrence, but the mechanisms behind the bias elimination are not fully understood...
December 19, 2016: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/27989405/aberrant-default-mode-network-homogeneity-in-patients-with-first-episode-treatment-naive-melancholic-depression
#9
Xilong Cui, Wenbin Guo, Yi Wang, Tian-Xiao Yang, Xin-Hua Yang, Yefei Wang, Jingbo Gong, Changlian Tan, Guangrong Xie
BACKGROUND: Melancholic depression is a relatively homogenous subtype of major depressive disorders (MDD). The condition has several endogenous symptoms and represents strong biological components. However, its specific neurobiological mechanisms remain unknown. Previous neuroimaging findings indicated that default mode network (DMN) is closely related to MDD. The present study examined the network homogeneity (NH) of the DMN in patients with melancholic MDD. METHODS: A total of 33 first-episode, treatment-naive melancholic MDD patients and 32 healthy controls underwent a resting-state functional magnetic resonance imaging scan...
February 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/27977069/biological-mechanism-of-post-herpetic-neuralgia-evidence-from-multiple-patho-psychophysiological-measures
#10
W W Peng, X L Guo, Q Q Jin, H Wei, X L Xia, Y Zhang, P C Huang, W C Wang, S L Li, J S Wang, J Chen, L Hu
BACKGROUND: Post-herpetic neuralgia (PHN), which develops after the resolution of a herpes zoster eruption, is an exceptionally drug-resistant neuropathic pain. The unsatisfactory management of PHN partly results from the difficulty in dissecting out its contributing factors due to the complexity of PHN mechanism. METHODS: Here, to elaborate our understanding of the PHN mechanism and to establish a basis for effective therapeutic strategies, we comprehensively investigated the contributions of multiple factors to PHN severity...
December 15, 2016: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/27956745/altered-brain-processing-of-decision-making-in-healthy-first-degree-biological-relatives-of-suicide-completers
#11
Y Ding, F Pereira, A Hoehne, M-M Beaulieu, M Lepage, G Turecki, F Jollant
Suicidal behavior is heritable, with the transmission of risk being related to the transmission of vulnerability traits. Previous studies suggest that risky decision-making may be an endophenotype of suicide. Here, we aimed at investigating brain processing of decision-making in relatives of suicide completers in order to shed light on heritable mechanisms of suicidal vulnerability. Seventeen healthy first-degree biological relatives of suicide completers with no personal history of suicidal behavior, 16 relatives of depressed patients without any personal or family history of suicidal behavior, and 19 healthy controls were recruited...
December 13, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27955897/orexins-mediate-sex-differences-in-the-stress-response-and-in-cognitive-flexibility
#12
Laura A Grafe, Amanda Cornfeld, Sandra Luz, Rita Valentino, Seema Bhatnagar
BACKGROUND: Women are twice as likely as men to experience stress-related psychiatric disorders. The biological basis of these sex differences is poorly understood. Orexins are altered in anxious and depressed patients. Using a rat model of repeated stress, we examined whether orexins contribute to sex differences in outcomes relevant to stress-related psychiatric diseases. METHODS: Behavioral, neural, and endocrine habituation to repeated restraint stress and subsequent cognitive flexibility was examined in adult male and female rats...
April 15, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/27717262/abandoning-personalization-to-get-to-precision-in-the-pharmacotherapy-of-depression
#13
Roy H Perlis
Effectiveness studies and analyses of naturalistic cohorts demonstrate that many patients with major depressive disorder do not experience symptomatic remission with antidepressant treatments. In an effort to better match patients with effective treatments, numerous investigations of predictors or moderators of treatment response have been reported over the past five decades, including clinical features as well as biological measures. However, none of these have entered routine clinical practice; instead, clinicians typically personalize treatment on the basis of patient preferences as well as their own...
October 2016: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
https://www.readbyqxmd.com/read/27641441/gut-instincts-microbiota-as-a-key-regulator-of-brain-development-ageing-and-neurodegeneration
#14
Timothy G Dinan, John F Cryan
There is a growing realisation that the gut-brain axis and its regulation by the microbiota may play a key role in the biological and physiological basis of neurodevelopmental, age-related and neurodegenerative disorders. The routes of communication between the microbiota and brain are being unravelled and include the vagus nerve, gut hormone signalling, the immune system, tryptophan metabolism or by way of microbial metabolites such as short chain fatty acids. The importance of early life gut microbiota in shaping future health outcomes is also emerging...
January 15, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/27629369/genome-wide-association-study-of-loneliness-demonstrates-a-role-for-common-variation
#15
Jianjun Gao, Lea K Davis, Amy B Hart, Sandra Sanchez-Roige, Lide Han, John T Cacioppo, Abraham A Palmer
Loneliness is a complex biological trait that has been associated with numerous negative health outcomes. The measurement and environmental determinants of loneliness are well understood, but its genetic basis is not. Previous studies have estimated the heritability of loneliness between 37 and 55% using twins and family-based approaches, and have explored the role of specific candidate genes. We used genotypic and phenotypic data from 10 760 individuals aged ⩾50 years that were collected by the Health and Retirement Study (HRS) to perform the first genome-wide association study of loneliness...
March 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27616990/locus-ceruleus-norepinephrine-release-a-central-regulator-of-cns-spatio-temporal-activation
#16
Marco Atzori, Roberto Cuevas-Olguin, Eric Esquivel-Rendon, Francisco Garcia-Oscos, Roberto C Salgado-Delgado, Nadia Saderi, Marcela Miranda-Morales, Mario Treviño, Juan C Pineda, Humberto Salgado
Norepinephrine (NE) is synthesized in the Locus Coeruleus (LC) of the brainstem, from where it is released by axonal varicosities throughout the brain via volume transmission. A wealth of data from clinics and from animal models indicates that this catecholamine coordinates the activity of the central nervous system (CNS) and of the whole organism by modulating cell function in a vast number of brain areas in a coordinated manner. The ubiquity of NE receptors, the daunting number of cerebral areas regulated by the catecholamine, as well as the variety of cellular effects and of their timescales have contributed so far to defeat the attempts to integrate central adrenergic function into a unitary and coherent framework...
2016: Frontiers in Synaptic Neuroscience
https://www.readbyqxmd.com/read/27612656/systems-biology-integration-of-proteomic-data-in-rodent-models-of-depression-reveals-involvement-of-the-immune-response-and-glutamatergic-signaling
#17
Lucia Carboni, Thanh-Phuong Nguyen, Laura Caberlotto
PURPOSE: The pathophysiological basis of major depression is incompletely understood. Recently, numerous proteomic studies have been performed in rodent models of depression to investigate the molecular underpinnings of depressive-like behaviours with an unbiased approach. The objective of the study is to integrate the results of these proteomic studies in depression models to shed light on the most relevant molecular pathways involved in the disease. EXPERIMENTAL DESIGN: Network analysis is performed integrating preexisting proteomic data from rodent models of depression...
December 2016: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/27609760/previous-motor-activity-affects-the-transition-from-uncertainty-to-decision-making-in-snails
#18
Tatiana A Korshunova, Dmitry D Vorontsov, Varvara E Dyakonova
One of the most widely accepted benefits of enhanced physical activity is an improvement in the symptoms of depression, including the facilitation of decision making. Up until now, these effects have been shown in rodents and humans only. Little is known about their evolutionary origin or biological basis, and the underlying cellular mechanisms also remain relatively elusive. Here, we demonstrate for the first time that preceding motor activity accelerates decision making in an invertebrate, the pond snail Lymnaea stagnalis To investigate decision making in a novel environment, snails, which normally live in water, were placed on a flat dry surface to simulate the potentially threatening consequence of being in an arid environment...
November 15, 2016: Journal of Experimental Biology
https://www.readbyqxmd.com/read/27567807/a-decade-of-cerebrospinal-fluid-biomarkers-for-alzheimer-s-disease-in-belgium
#19
Charisse Somers, Hanne Struyfs, Joery Goossens, Ellis Niemantsverdriet, Jill Luyckx, Naomi De Roeck, Ellen De Roeck, Bart De Vil, Patrick Cras, Jean-Jacques Martin, Peter-Paul De Deyn, Maria Bjerke, Sebastiaan Engelborghs
During the past ten years, over 5,000 cerebrospinal fluid (CSF) samples were analyzed at the Reference Center for Biological Markers of Dementia (BIODEM), UAntwerp, for core Alzheimer's disease (AD) CSF biomarkers: amyloid-β peptide of 42 amino acids (Aβ1-42), total tau protein (T-tau), and tau phosphorylated at threonine 181 (P-tau181P). CSF biomarker analyses were performed using single-analyte ELISA kits. In-house validated cutoff values were applied: Aβ1-42 <638.5 pg/mL, T-tau >296.5 pg/mL, P-tau181P >56...
August 10, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27559167/partial-breakdown-of-input-specificity-of-stdp-at-individual-synapses-promotes-new-learning
#20
Maxim Volgushev, Jen-Yung Chen, Vladimir Ilin, Roman Goz, Marina Chistiakova, Maxim Bazhenov
UNLABELLED: Hebbian-type learning rules, which underlie learning and refinement of neuronal connectivity, postulate input specificity of synaptic changes. However, theoretical analyses have long appreciated that additional mechanisms, not restricted to activated synapses, are needed to counteract positive feedback imposed by Hebbian-type rules on synaptic weight changes and to achieve stable operation of learning systems. The biological basis of such mechanisms has remained elusive. Here we show that, in layer 2/3 pyramidal neurons from slices of visual cortex of rats, synaptic changes induced at individual synapses by spike timing-dependent plasticity do not strictly follow the input specificity rule...
August 24, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
keyword
keyword
113942
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"