Vidya Chandrasekaran, Sara Wellens, Aurore Bourguignon, Ivo Djidrovski, Leonie Fransen, Sreya Ghosh, Zahra Mazidi, Cormac Murphy, Carolina Nunes, Pranika Singh, Melinda Zana, Lyle Armstrong, András Dinnyés, Johannes Grillari, Regina Grillari-Voglauer, Martin O Leonard, Catherine Verfaillie, Anja Wilmes, Marie-Gabrielle Zurich, Thomas Exner, Paul Jennings, Maxime Culot
Human induced pluripotent stem cells (iPSC) have the potential to produce desired target cell types in vitro and allow for the high-throughput screening of drugs/chemicals at population level thereby minimising the cost of drug discovery and drug withdrawals after clinical trials. There is a substantial need for the characterisation of the iPSC derived models to better understand and utilise them for toxicological relevant applications. In our study, iPSC (SBAD2 or SBAD3 lines obtained from StemBANCC project) were differentiated towards toxicologically relevant cell types: alveolar macrophages, brain capillary endothelial cells, brain cells, endothelial cells, hepatocytes, lung airway epithelium, monocytes, podocytes and renal proximal tubular cells...
April 12, 2024: Toxicology in Vitro: An International Journal Published in Association with BIBRA