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angioimmunoblastic lymhoma

Yee Soo Choe, Jong Gwang Kim, Sang Kyun Sohn, Dong Hwan Kim, Jin Ho Baek, Kyu Bo Lee, Young Rok Do, Ki Young Kwon, Hong Suk Song, Myung Hoon Lee, Tae In Park
The present study evaluated the expression and mutations of c-kit in peripheral T-cell lymphomas (PTCLs), except for extra-nodal NK/T cell lymphomas, as a potential target for treatment with imatinib mesylate. Fifty-two patients diagnosed with PTCLs (peripheral T-cell lymhoma, unspecified, 38 cases; angioimmunoblastic T-cell, 7 cases; anaplastic large cell, 7 cases) were enrolled. The immunohistochemistry was performed using standard procedures with anti-c-kit monoclonal IgG, while the c-kit mutations were analysed on paraffin-embedded specimens using PCR-single-stranded conformational polymorphism followed by direct DNA sequencing...
February 2006: Leukemia & Lymphoma
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