keyword
MENU ▼
Read by QxMD icon Read
search

Opioid withdrawal

keyword
https://www.readbyqxmd.com/read/29922811/new-relief-for-opioid-withdrawal
#1
Rebecca Voelker
No abstract text is available yet for this article.
June 19, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29922741/linking-opioid-induced-hyperalgesia-and-withdrawal-associated-injury-site-pain-a-case-report
#2
Launette Marie Rieb, Wendy V Norman, Ruth Elwood Martin, Jonathan Berkowitz, Evan Wood, Michael John Milloy, Ryan McNeil
Introduction and objectives: Understanding the details of one individual's experience with pain, opioid use and withdrawal may generate insights into possible relationships between opioid-induced hyperalgesia and withdrawal-associated injury site pain (WISP). Methods: This case study was extracted from a mixed methods study that characterized WISP. In 2014, the individual was recruited from a primary care clinic that prescribes opioid agonist therapy. In an interview, she completed a 35-item survey and elaborated on her own experience...
May 2018: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29922156/ibogaine-detoxification-transitions-opioid-and-cocaine-abusers-between-dependence-and-abstinence-clinical-observations-and-treatment-outcomes
#3
Deborah C Mash, Linda Duque, Bryan Page, Kathleen Allen-Ferdinand
Ibogaine may be effective for transitioning opioid and cocaine dependent individuals to sobriety. American and European self-help groups provided public testimonials that ibogaine alleviated drug craving and opioid withdrawal symptoms after only a single dose administration. Preclinical studies in animal models of addiction have provided proof-of-concept evidence in support of these claims. However, the purported therapeutic benefits of ibogaine are based on anecdotal reports from a small series of case reports that used retrospective recruitment procedures...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29913983/a-6-months-randomised-placebo-controlled-evaluation-of-efficacy-and-tolerability-of-a-low-dose-7-day-buprenorphine-transdermal-patch-in-osteoarthritis-patients-na%C3%A3-ve-to-potent-opioids
#4
Harald Breivik, Tone Marte Ljosaa, Kristian Stengaard-Pedersen, Jan Persson, Hannu Aro, John Villumsen, Dorthe Tvinnemose
Objective Patients with osteoarthritis (OA) pain often have insufficient pain relief from non-opioid analgesics. The aim of this trial was to study efficacy and tolerability of a low dose 7-day buprenorphine transdermal delivery system, added to a NSAID or coxib regimen, in opioid-naïve patients with moderate to severe OA pain. Methods A 6 months randomised, double-blind, parallel-group study at 19 centres in Denmark, Finland, Norway, and Sweden, in which OA patients (>40 years) with at least moderate radiographic OA changes and at least moderate pain in a hip and/or knee while on a NSAID or a coxib were randomised to a 7-day buprenorphine patch (n = 100) or an identical placebo patch (n = 99)...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913911/buprenorphine-clinically-useful-but-often-misunderstood
#5
Stephen Butler
Background There are a number of false myths about buprenorphine based on unconfirmed animal data, even from isolated animal organs, and early clinical research. These myths came into textbooks on pharmacology and pain about 30 years ago and have been difficult to eradicate. Animal models of pain and pain relief are notoriously unreliable as predictors of human clinical effects. The fact is that in clinical practice there is NO bell-shaped dose-response curve, there is NO plateau on the dose-response curve, and there is NO antagonist effect from buprenorphine on other mu-opioid agonists...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29910009/lofexidine-versus-diazepam-for-the-treatment-of-opioid-withdrawal-syndrome-a-double-blind-randomized-clinical-trial-in-singapore
#6
Song Guo, Victoria Manning, Yi Yang, Puay Kee Koh, Edwin Chan, Nurun Nisa de Souza, Pryseley Nkouibert Assam, Rehena Sultana, Ruki Wijesinghe, Julius Pangjaya, Gomathinayagam Kandasami, Christopher Cheok, Kae Meng Lee, Kim Eng Wong
BACKGROUND: Many individuals leave costly inpatient detoxification programs prematurely because of the severity of withdrawal symptoms experienced. In the absence of opioid-assisted detoxification in Singapore, diazepam is used to manage withdrawal. However since diazepam is addictive, there is a need to explore the effectiveness of alternative medications. DESIGN AND PROCEDURES: The study aimed to examine the safety and efficacy of lofexidine, a non-opiate, non-addictive, alpha 2-adrenergic agonist in assisting opioid detoxification in Singapore, using a randomized, double-blind, investigator-initiated placebo-controlled trial comparing lofexidine against diazepam...
August 2018: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29905630/ultrasound-guided-percutaneous-peripheral-nerve-stimulation-neuromodulation-of-the-sciatic-nerve-for-postoperative-analgesia-following-ambulatory-foot-surgery-a-proof-of-concept-study
#7
Brian M Ilfeld, Rodney A Gabriel, Engy T Said, Amanda M Monahan, Jacklynn F Sztain, Wendy B Abramson, Bahareh Khatibi, John J Finneran, Pia T Jaeger, Alexandra K Schwartz, Sonya S Ahmed
BACKGROUND AND OBJECTIVES: Percutaneous peripheral nerve stimulation (PNS) is an analgesic modality involving the insertion of a lead through an introducing needle followed by the delivery of electric current. This modality has been reported to treat chronic pain as well as postoperative pain the day following knee surgery. However, it remains unknown if this analgesic technique may be used in ambulatory subjects following foot procedures beginning within the recovery room immediately following surgery, and with only short series of patients reported to date, the only available data are derived from strictly observational studies...
June 13, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29901032/emotion-recognition-and-its-relation-to-prefrontal-function-and-network-in-heroin-plus-nicotine-dependence-a-pilot-study
#8
Hada Fong-Ha Ieong, Zhen Yuan
Many patients with substance use disorders (SUDs) live in a stressful environment, and comorbidity is not uncommon. Understanding the neural mechanisms underlying heroin and nicotine dependences and their relationships to social cognition could facilitate behavioral therapy efficacy. We aimed to provide a translational approach that leads to identifying potential biomarkers for opioid use disorder (OUD) susceptibility during recovery. We examined the clinical characters and the relationships between theory of mind (ToM) and executive functions in three groups: heroin plus nicotine-dependent (HND) patients who had remained heroin abstinent ( <mml:math xmlns:mml="http://www...
April 2018: Neurophotonics
https://www.readbyqxmd.com/read/29894447/corrected-qt-interval-prolongation-in-hospitalized-pediatric-patients-receiving-methadone
#9
Amy J Schwinghammer, Machelle D Wilson, Brent A Hall
OBJECTIVES: Methadone is often used in pediatric patients to prevent or treat opioid withdrawal after prolonged sedation. Prolonged corrected QT interval is an important adverse effect of methadone because it can progress to torsades de pointes, a potentially fatal dysrhythmia. The prevalence of corrected QT interval prolongation and contributing risk factors are not well defined in hospitalized pediatric patients receiving methadone. The study purpose was to identify the frequency and risk factors of corrected QT interval prolongation in hospitalized pediatric patients receiving methadone...
June 11, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29893624/developmental-disorders-and-medical-complications-among-infants-with-subclinical-intrauterine-opioid-exposures
#10
Eric S Hall, Jennifer M McAllister, Scott L Wexelblatt
The objective was to compare diagnosis rates representing developmental outcomes and medical complications between infants with intrauterine opioid exposures who did not receive pharmacologic treatment for neonatal abstinence syndrome at the time of birth and infants for whom no exposure to substances of abuse were detected. This retrospective, descriptive study included approximately 95% of Hamilton County, Ohio resident births in 2014 and 2015. Universal maternal drug test results, performed at the time of birth, were documented and linked to electronic health records representing pediatric primary and subspecialty follow-up care as well as urgent care, emergency care, and inpatient services provided by Cincinnati Children's Hospital Medical Center through 2017, when all children were at least 24 months old...
June 12, 2018: Population Health Management
https://www.readbyqxmd.com/read/29880438/identification-management-and-transition-of-care-for-patients-with-opioid-use-disorder-in-the-emergency-department
#11
REVIEW
Herbert C Duber, Isabel A Barata, Eric Cioè-Peña, Stephen Y Liang, Eric Ketcham, Wendy Macias-Konstantopoulos, Shawn A Ryan, Mark Stavros, Lauren K Whiteside
Because of a soaring number of opioid-related deaths during the past decade, opioid use disorder has become a prominent issue in both the scientific literature and lay press. Although most of the focus within the emergency medicine community has been on opioid prescribing-specifically, on reducing the incidence of opioid prescribing and examining alternative pain treatment-interest is heightening in identifying and managing patients with opioid use disorder in an effective and evidence-based manner. In this clinical review article, we examine current strategies for identifying patients with opioid use disorder, the treatment of patients with acute opioid withdrawal syndrome, approaches to medication-assisted therapy, and the transition of patients with opioid use disorder from the emergency department to outpatient services...
June 4, 2018: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29869799/mu-opioid-antagonists-for-opioid-induced-bowel-dysfunction-in-people-with-cancer-and-people-receiving-palliative-care
#12
REVIEW
Bridget Candy, Louise Jones, Victoria Vickerstaff, Philip J Larkin, Patrick Stone
BACKGROUND: Opioid-induced bowel dysfunction (OIBD) is characterised by constipation, incomplete evacuation, bloating, and gastric reflux. It is one of the major adverse events of treatment for pain in cancer and in palliative care, resulting in increased morbidity and reduced quality of life.This is an update of two Cochrane reviews. One was published in 2011, Issue 1 on laxatives and methylnaltrexone for the management of constipation in people receiving palliative care; this was updated in 2015 and excluded methylnaltrexone...
June 5, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29867508/inhibition-of-histone-deacetylases-attenuates-morphine-tolerance-and-restores-mor-expression-in-the-drg-of-bcp-rats
#13
Xiao-Tao He, Kai-Xiang Zhou, Wen-Jun Zhao, Chen Zhang, Jian-Ping Deng, Fa-Ming Chen, Ze-Xu Gu, Yun-Qing Li, Yu-Lin Dong
The easily developed morphine tolerance in bone cancer pain (BCP) significantly hindered its clinical use. Increasing evidence suggests that histone deacetylases (HDACs) regulate analgesic tolerance subsequent to continuous opioid exposure. However, whether HDACs contribute to morphine tolerance in the pathogenesis of BCP is still unknown. In the current study, we explored the possible engagement of HDACs in morphine tolerance during the pathogenesis of BCP. After intra-tibia tumor cell inoculation (TCI), we found that the increased expression of HDACs was negatively correlated with the decreased expression of MOR in the DRG following TCI...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29859931/serum-bdnf-levels-in-patients-with-opioid-dependence-during-the-early-withdrawal-period-a-case-control-study
#14
Siddharth Sarkar, Raka Jain, Shanti M Kethawat, Rishi Gupta, Mukesh Kumar
BACKGROUND AND AIMS: Brain-Derived Neurotrophic Factor (BDNF), a neuropeptide important for neural growth and differentiation has been explored in patients with opioid dependence. We aimed to compare the serum BDNF levels in patients with opioid dependence with age and gender matched controls, and to assess change in BDNF levels during initial withdrawal period. METHODS: Thirty cases with a diagnosis of opioid dependence were compared to forty healthy controls. BDNF levels were measured at inclusion for all participants...
May 31, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29859324/treadmill-exercise-attenuates-the-severity-of-physical-dependence-anxiety-depressive-like-behavior-and-voluntary-morphine-consumption-in-morphine-withdrawn-rats-receiving-methadone-maintenance-treatment
#15
Maryam Alizadeh, Mahdi Zahedi-Khorasani, Hossein Miladi-Gorji
This study was designed to examine whether treadmill exercise would attenuate the severity of physical dependence, methadone-induced anxiety, depression and voluntary morphine consumption in morphine withdrawn rats receiving methadone maintenance treatment (MMT). The rats were chronically treated with bi-daily doses (10 mg/kg, at 12 h intervals) of morphine for 14 days. The exercising rats receiving MMT were forced to run on a motorized treadmill for 30 days during morphine withdrawal. Then, rats were tested for the severity of morphine dependence, the elevated plus-maze (EPM), sucrose preference test (SPT) and voluntary morphine consumption using a two-bottle choice (TBC) paradigm...
May 30, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29852138/differential-effects-of-left-and-right-neuropathy-on-opioid-gene-expression-in-lumbar-spinal-cord
#16
Olga Kononenko, Irina Mityakina, Vladimir Galatenko, Hiroyuki Watanabe, Igor Bazov, Anna Gerashchenko, Daniil Sarkisyan, Anna Iatsyshyna, Tatiana Yakovleva, Alex Tonevitsky, Niklas Marklund, Michael H Ossipov, Georgy Bakalkin
The endogenous opioid system (EOS) controls the processing of nociceptive stimuli and is a pharmacological target for opioids. Alterations in expression of the EOS genes under neuropathic pain condition may account for low efficacy of opioid drugs. We here examined whether EOS expression patterns are altered in the lumbar spinal cord of the rats with spinal nerve ligation (SNL) as a neuropathic pain model. Effects of the left- and right-side SNL on expression of EOS genes in the ipsi- and contralateral spinal domains were analysed...
May 28, 2018: Brain Research
https://www.readbyqxmd.com/read/29849948/additive-analgesic-effect-of-dexmedetomidine-and-dezocine-administered-intrathecally-in-a-mouse-pain-model
#17
Ya-Qin Huang, Shao-Hui Guo, Renyu Liu, Sheng-Mei Zhu, Jian-Liang Sun, Yong-Xing Yao
Background: It is known that dexmedetomidine can reduce opioid requirements and that there is a synergistic effect when dexmedetomidine and morphine (a full mu opioid receptor agonist) are administered together. However, it was unclear whether a synergistic or additive effect would be observed when dexmedetomidine was co-administered with a partial mu opioid receptor agonist. The present study was designed to elucidate such effects by intrathecally co-administering dexmedetomidine and dezocine, a partial mu receptor agonist, in a mouse pain model...
May 11, 2018: Oncotarget
https://www.readbyqxmd.com/read/29848240/identifying-and-treating-codeine-dependence-a-systematic-review
#18
Suzanne Nielsen, Tim MacDonald, Jacinta L Johnson
OBJECTIVES: Codeine dependence is a significant public health problem, motivating the recent rescheduling of codeine in Australia (1 February 2018). To provide information for informing clinical responses, we undertook a systematic review of what is known about identifying and treating codeine dependence. STUDY DESIGN: Articles published in English that described people who were codeine-dependent or a clinical approach to treating people who were codeine-dependent, without restriction on year of publication, were reviewed...
June 4, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/29807218/alcohol-use-disorder-and-associated-physical-health-complications-and-treatment-amongst-individuals-with-and-without-opioid-dependence-a-case-control-study
#19
Margaret Pikovsky, Amy Peacock, Sarah Larney, Briony Larance, Elizabeth Conroy, Elliot Nelson, Louisa Degenhardt
BACKGROUND: Dependence upon one substance may increase vulnerability for dependence on other substances. This study aimed to i) examine the association between opioid dependence and alcohol use and dependence; and ii) identify demographic, mental health, substance use, and alcohol-related withdrawal, physical health complications, and treatment correlates of comorbid alcohol and opioid dependence versus the former only. METHODS: In this case-control study, 1475 participants with opioid dependence recruited from opioid substitution therapy (OST) clinics and 516 non-opioid dependent matched participants completed a structured interview covering psychiatric history, substance dependence, child maltreatment, and history of alcohol use...
May 21, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29803784/injectable-nanocomposite-analgesic-delivery-system-for-musculoskeletal-pain-management
#20
Manakamana Khanal, Shalini V Gohil, Emmanuel Kuyinu, Ho-Man Kan, Brittany E Knight, Kyle M Baumbauer, Kevin W-H Lo, Joseph Walker, Cato T Laurencin, Lakshmi S Nair
Musculoskeletal pain is a major health issue which results from surgical procedures (i.e. total knee and/ or hip replacements and rotator cuff repairs), as well as from non-surgical conditions (i.e. sympathetically-mediated pain syndrome and occipital neuralgia). Local anesthetics, opioids or corticosteroids are currently used for the pain management of musculoskeletal conditions. Even though local anesthetics are highly preferred, the need for multiple administration presents significant disadvantages. Development of unique delivery systems that can deliver local anesthetics at the injection site for prolonged time could significantly enhance the therapeutic efficacy and patient comfort...
May 24, 2018: Acta Biomaterialia
keyword
keyword
11393
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"