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Diet and gout

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https://www.readbyqxmd.com/read/28249154/%C3%AE-hydroxybutyrate-deactivates-neutrophil-nlrp3-inflammasome-to-relieve-gout-flares
#1
Emily L Goldberg, Jennifer L Asher, Ryan D Molony, Albert C Shaw, Caroline J Zeiss, Chao Wang, Ludmilla A Morozova-Roche, Raimund I Herzog, Akiko Iwasaki, Vishwa Deep Dixit
Aging and lipotoxicity are two major risk factors for gout that are linked by the activation of the NLRP3 inflammasome. Neutrophil-mediated production of interleukin-1β (IL-1β) drives gouty flares that cause joint destruction, intense pain, and fever. However, metabolites that impact neutrophil inflammasome remain unknown. Here, we identified that ketogenic diet (KD) increases β-hydroxybutyrate (BHB) and alleviates urate crystal-induced gout without impairing immune defense against bacterial infection. BHB inhibited NLRP3 inflammasome in S100A9 fibril-primed and urate crystal-activated macrophages, which serve to recruit inflammatory neutrophils in joints...
February 28, 2017: Cell Reports
https://www.readbyqxmd.com/read/28238670/association-of-pregnancy-with-stone-formation-among-us-women-a-national-health-and-nutrition-examination-survey-analysis-2007-2012
#2
Lael Reinstatler, Sari Khaleel, Vernon M Pais
PURPOSE: Lithogenic urinary changes occur during pregnancy. Such changes may increase stone proclivity in working and child rearing aged women thereafter. However, such an association has not been previously identified. MATERIALS AND METHODS: We analyzed nationally representative data from 2007-2012 National Health and Nutrition Examination Survey to assess the association between pregnancy and nephrolithiasis. RESULTS: The weighted national prevalence of nephrolithiasis among women ≤50 was 6...
February 23, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28223818/an-evidence-based-review-on-urate-lowering-treatments-implications-for-optimal-treatment-of-chronic-hyperuricemia
#3
REVIEW
Marilisa Bove, Arrigo Francesco Giuseppe Cicero, Maddalena Veronesi, Claudio Borghi
Several studies suggest that chronic hyperuricemia, the main precursor of gout, is involved in the pathogenesis of different systemic disorders that affect cardiovascular and renal systems, such as hypertension, obesity, hypercholesterolemia, atherosclerosis, metabolic syndrome, chronic heart failure, and chronic kidney disease. Recent epidemiological evidence has shown an increasing trend in the prevalence of hyperuricemia and gout in the Western world: a number of population-based studies estimate a prevalence of up to 21% for hyperuricemia and 1%-4% for gout...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28163851/a-systematic-review-of-the-relationship-between-dystemprament-sue-mizaj-and-treatments-and-management-of-diseases-ilaj-and-eslah-e-mizaj
#4
REVIEW
Sepide Miraj, Samira Alesaeidi, Sara Kiani
BACKGROUND: Temperament refers to four different humors differentiating in individuals and, as a result, proposes specific therapy for diseases as well as special types of management (avoidance). OBJECTIVE: The aim of this study was to overview the relationship between dystemprament and treatment and management of diseases. METHODS: A computerized search of published articles was performed using PubMed, Scopus, Web of Science, and Medline databases as well as local sources from 1965 to 2016...
December 2016: Electronic Physician
https://www.readbyqxmd.com/read/28118526/gout-self-management-in-african-american-veterans-a-qualitative-exploration-of-challenges-and-solutions-from-patients-perspectives
#5
Jasvinder A Singh, Ivan Herbey, Aseem Bharat, Janet E Dinnella, Sally Pullman-Mooar, Seth Eisen, Nataliya Ivankova
OBJECTIVE: To explore gout self-management and associated challenges and solutions in African-Americans. METHODS: We conducted semi-structured interviews with 35 African-Americans veterans with gout, who received healthcare at Birmingham or Philadelphia Veterans Affairs (VA) medical centers, had filled urate-lowering therapy (ULT; most commonly allopurinol) for at least 6 months and had ULT a medication possession ratio ≥80%. The interview protocol was constructed to explore key concepts related to gout self-management, including: initial diagnosis of gout, beginning medical care for gout, the course of the gout, ULT medication adherence, dietary strategies, comorbidity and side effects, and social support...
January 24, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/27906623/orotate-orotic-acid-an-essential-and-versatile-molecule
#6
REVIEW
M Löffler, E A Carrey, E Zameitat
Orotate (OA) is well-known as a precursor in biosynthesis of pyrimidines; in mammals it is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. OA is also a normal part of the diet, being found in milk and dairy products, and it is converted to uridine for use in the pyrimidine salvage pathway predominantly in liver, kidney and erythrocytes. Early research into nutrition identified orotate as "vitamin B13," and its use as a complex with organic cations or metal ions was promulgated in body-building, and in assisting therapies of metabolic syndromes...
December 2016: Nucleosides, Nucleotides & Nucleic Acids
https://www.readbyqxmd.com/read/27825577/efficacy-and-safety-of-febuxostat-in-73-gouty-patients-with-stage-4-5-chronic-kidney-disease-a-retrospective-study-of-10-centers
#7
Pierre-Antoine Juge, Marie-Elise Truchetet, Evangeline Pillebout, Sébastien Ottaviani, Cécile Vigneau, Clotilde Loustau, Divi Cornec, Tristan Pascart, Renaud Snanoudj, Florian Bailly, Emilie Cornec-Le Gall, Thierry Schaeverbeke, Alain Saraux, Philippe Dieudé, René-Marc Flipo, Pascal Richette, Frédéric Lioté, Thomas Bardin, Gérard Chalès, Hang-Korng Ea
OBJECTIVES: The allopurinol dose is limited in chronic kidney disease, particularly stage 4/5 chronic kidney disease. Febuxostat has a hepatic metabolism and has been approved without dose adaptation in gouty patients with stage 1-3 chronic kidney disease. We aimed to study the safety and efficacy of febuxostat for stage 4/5 chronic kidney disease. METHODS: In this retrospective study, we included patients with (1) a diagnosis of gout, (2) febuxostat treatment, (3) estimated glomerular filtration rate≤30mL/min/1...
November 4, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27749216/on-the-history-of-gout-paleopathological-evidences-from-the-medici-family-of-florence
#8
Valentina Giuffra, Simona Minozzi, Angelica Vitiello, Antonio Fornaciari
OBJECTIVES: Throughout history, gout has been referred to as the "disease of the kings", and has been clearly associated with the lifestyle of the aristocratic social classes. According to the written sources, several members of the famous Medici family of Florence suffered from an arthritic disease that contemporary physicians called "gout". A paleopathological study carried out on the skeletal remains of some members of the family, exhumed from their tombs in the Church of San Lorenzo in Florence, offered a unique opportunity to directly investigate the evidence of the arthritic diseases affecting this elite group...
September 7, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27729624/metabolic-syndrome-prevalence-and-risk-factors-in-korean-gout-patients
#9
Jae Hyun Jung, Gwan Gyu Song, Jong Dae Ji, Young Ho Lee, Jae-Hoon Kim, Young Ho Seo, Sung Jae Choi
Background/Aims: We performed this study to investigate associations between metabolic syndrome, chronic kidney disease (CKD), and gout. Methods: We reviewed the medical records of 151 patients with gout at the Department of Rheumatology in Korea University Ansan Hospital. The following measures were examined: waist circumference, blood pressure, alcohol consumption, and levels of triglyceride, high density lipoprotein cholesterol, fasting serum glucose, serum uric acid (SUA), creatinine, insulin, and C-peptide...
October 12, 2016: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/27722972/the-management-of-gout-in-different-clinical-specialties-in-turkey-a-patient-based-survey
#10
Mehmet Akif Öztürk, Rıdvan Mercan, Kevser Gök, Ahmet Mesut Onat, Bünyamin Kısacık, Gezmiş Kimyon, Ayşe Balkarlı, Arif Kaya, Veli Çobankara, Mehmet Ali Balcı, ÖmerNuri Pamuk, Gözde Yıldırım Çetin, Mehmet Sayarlıoğlu, Soner Şenel, Mehmet Engin Tezcan, Adem Küçük, Kemal Üreten, Şafak Şahin, Abdurrahman Tufan
Although gout is potentially curable, the management of this disease is often suboptimal. In this study, we investigated the treatment of gout in Turkey and also compared the management approaches to gout in different clinical specialties. Three hundred and nineteen consecutive patients (mean age 58.60 ± 12.8 years; 44 females, 275 males) were included in this multicenter study. A standardized form was generated to collect data about the patient's first admission to health care, the specialty of the doctor first diagnosed the gout, the treatment options for gout including attack management, patient referral, chronic treatment including medical treatment, and life style modifications...
December 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27666904/pathogenesis-and-clinical-management-of-gouty-arthritis
#11
Renu Saigal, Abhishek Agrawal
Gout, the most common of the crystal arthritides is a result of disturbed uric acid metabolism and precipitation of urate crystals in extra cellular space of joints, periarticular tissue, bones and other organs. In the West, gout affects around 1% of adult men over 45 years of age. The estimated incidence being 0.6 to 2.1 per 1000 per year, with a prevalence of 9.5 to 13.5 per 1000 persons of all ages.1 The incidence of gout has been on rise globally; potentially attributable to recent shifts in diet, lifestyle, medical care, and increased longevity...
December 2015: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27577288/a-healthy-diet-may-be-key-to-preventing-gout-flare-ups
#12
(no author information available yet)
Choosing the right foods can help manage gout. Avoiding saturated fats and concentrating on fruit, vegetables and low-fat dairy foods may be the most effective non-pharmacologic way to combat the gout, say researchers.
August 31, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27558643/overview-of-serum-uric-acid-treatment-targets-in-gout-why-less-than-6-mg-dl
#13
REVIEW
Gary Ruoff, N Lawrence Edwards
Gout is a progressive, painful, debilitating form of inflammatory arthritis. It is caused by factors that elevate the concentration of serum uric acid (sUA), leading to hyperuricemia (sUA >6.8 mg/dL). Continued elevated sUA can result in monosodium urate (MSU) crystal deposition in joints and soft tissues, and can cause acute and chronic inflammation. The prevalence of hyperuricemia and gout has increased over the last few decades, likely due to an aging population, changes in lifestyles and diet, and an increase in gout-associated comorbidities...
September 2016: Postgraduate Medicine
https://www.readbyqxmd.com/read/27528713/healthy-diet-could-prevent-gout-flares-study-finds
#14
Susan Mayor
No abstract text is available yet for this article.
August 14, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27523583/effects-of-the-dietary-approaches-to-stop-hypertension-dash-diet-and-sodium-intake-on-serum-uric-acid
#15
Stephen P Juraschek, Allan C Gelber, Hyon K Choi, Lawrence J Appel, Edgar R Miller
OBJECTIVE: Randomized trial data guiding dietary recommendations to lower serum uric acid (UA), the etiologic precursor of gout, are scarce. We undertook this study to examine the effects of the Dietary Approaches to Stop Hypertension (DASH) diet (a well-established diet that lowers blood pressure) and levels of sodium intake on serum UA. METHODS: We conducted an ancillary study of a randomized, crossover feeding trial in 103 adults with prehypertension or stage I hypertension...
December 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27496979/dietary-fiber-and-the-short-chain-fatty-acid-acetate-promote-resolution-of-neutrophilic-inflammation-in-a-model-of-gout-in-mice
#16
Angélica T Vieira, Izabela Galvão, Laurence M Macia, Érica M Sernaglia, Marco Aurélio R Vinolo, Cristiana C Garcia, Luciana P Tavares, Flávio A Amaral, Lirlândia P Sousa, Flaviano S Martins, Charles R Mackay, Mauro M Teixeira
Gout is a disease characterized by the deposition of monosodium urate (MSU) crystals in the joints. Continuous gout episodes may lead to unresolved inflammatory responses and tissue damage. We investigated the effects of a high-fiber diet and acetate, a short-chain fatty acid (SCFA) resulting from the metabolism of fiber by gut microbiota, on the inflammatory response in an experimental model of gout in mice. Injection of MSU crystals into the knee joint of mice induced neutrophil influx and inflammatory hypernociception...
January 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/27488444/obesity-and-urolithiasis-evidence-of-regional-influences
#17
Alberto Trinchieri, Emanuele Croppi, Emanuele Montanari
There is evidence that obese patients have an increased risk of renal stone formation, although this relationship could be less evident in some populations. The aim of this study was to evaluate the impact of overweight and obesity on the risk of renal stone formation in a population consuming a Mediterranean diet and to better elucidate the mechanisms underlying the increased risk of urolithiasis observed in obese subjects. We performed a retrospective review of 1698 stone forming patients (mean age 45.9 ± 14...
August 3, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27452679/update-on-importance-of-diet-in-gout
#18
Randall N Beyl, Laura Hughes, Sarah Morgan
Gout is an inflammatory arthritis caused by deposition of monosodium urate crystals within synovial joints. Although it is most well-known for its arthritis, gout has an intimate relationship with many other cardiovascular and metabolic conditions. Current recommendations support aggressive medical therapy to treat gout while dietary counseling has become less emphasized. This article argues for the absolute importance of dietary counseling in gout and proves why this counseling may impact the long term well-being of a patient with gout...
July 21, 2016: American Journal of Medicine
https://www.readbyqxmd.com/read/27324603/patients-with-gout-differ-from-healthy-subjects-in-renal-response-to-changes-in-serum-uric-acid
#19
Sha Liu, Fernando Perez-Ruiz, Jeffrey N Miner
OBJECTIVE: Our objectives were to determine whether a change in serum uric acid (sUA) resulted in a corresponding change in the fractional excretion of uric acid (FEUA) and whether the renal response was different in patients with gout versus healthy subjects. METHODS: FEUA was calculated from previously published studies and four new phase I studies in healthy subjects and/or patients with gout before and after treatment to lower or raise sUA. Treatments included xanthine oxidase inhibitors to lower sUA as well as infusion of uric acid and provision of a high-purine diet to raise sUA...
June 17, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27260408/juniperus-rigida-sieb-extract-inhibits-inflammatory-responses-via-attenuation-of-trif-dependent-signaling-and-inflammasome-activation
#20
Ji-Won Han, Do-Wan Shim, Woo-Young Shin, Myong-Ki Kim, Eun-Jeong Shim, Xiao Sun, Sushruta Koppula, Tack-Joong Kim, Tae-Bong Kang, Kwang-Ho Lee
ETHNOPHARMACOLOGICAL RELEVANCE: Juniperus rigida Sieb. (J. rigida) is used for medicinal purposes in Asian countries to treat inflammation-related disorders, such as neuralgia, dropsy, and gout. AIM OF THE STUDY: The anti-inflammatory effects of J. rigida extract (JR) and its underlying mechanisms were explored both in in vitro cell lines and in vivo metabolic disease models. MATERIAL AND METHODS: Lipopolysaccharide (LPS)-stimulated RAW264...
August 22, 2016: Journal of Ethnopharmacology
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