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Diet and gout

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https://www.readbyqxmd.com/read/29595284/-treat-to-target-in-gouty-arthritis
#1
Karel Pavelka
Gout is a crystal-induced, metabolically determined inflammatory rheumatic disease with increasing prevalence. In clinical practice, gout causes frequent diagnostic as well as therapeutic problems. The golden diagnostic standard is crystalographic analysis and evidence of monosodium urate crystals in the polarization microscope; if this is not available, the diagnosis can be established through a combination of clinical, laboratory and imaging techniques. The acute gouty attack must be treated by quick administration of anti-inflammatory medicines, with available alternatives being nonsteroidal antirheumatic drugs (NSA), colchicine and glucocorticoids...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29526820/benzbromarone-aggravates-hepatic-steatosis-in-obese-individuals
#2
Peng Sun, Jing-Jie Zhu, Ting Wang, Qi Huang, Yu-Ren Zhou, Bang-Wei Yu, Hua-Liang Jiang, He-Yao Wang
As a widely used anti-gout drug, benzbromarone has been found to induce hepatic toxicity in patients during clinical treatment. Previous studies have reported that benzbromarone is metabolized via cytochrome P450, thus causing mitochondrial toxicity in hepatocytes. In this study, we found that benzbromarone significantly aggravated hepatic steatosis in both obese db/db mice and high fat diet (HFD)-induced obese (DIO) mouse models. However, benzbromarone had less effect on the liver of lean mice. It was found that the expression of mRNAs encoding lipid metabolism and some liver-specific genes were obviously disturbed in benzbromarone-treated DIO mice compared to the control group...
June 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29518206/the-science-of-obesity-management-an-endocrine-society-scientific-statement
#3
George A Bray, William E Heisel, Ashkan Afshin, Michael D Jensen, William H Dietz, Michael Long, Robert F Kushner, Stephen R Daniels, Thomas A Wadden, Adam G Tsai, Frank B Hu, John M Jakicic, Donna H Ryan, Bruce M Wolfe, Thomas H Inge
The prevalence of obesity, measured by body mass index, has risen to unacceptable levels in both men and women in the United States and worldwide with resultant hazardous health implications. Genetic, environmental, and behavioral factors influence the development of obesity, and both the general public and health professionals stigmatize those who suffer from the disease. Obesity is associated with and contributes to a shortened life span, type 2 diabetes mellitus, cardiovascular disease, some cancers, kidney disease, obstructive sleep apnea, gout, osteoarthritis, and hepatobiliary disease, among others...
April 1, 2018: Endocrine Reviews
https://www.readbyqxmd.com/read/29446654/hypouricaemic-effects-of-yoghurt-containing-lactobacillus-gasseri-pa-3-in-patients-with-hyperuricaemia-and-or-gout-a-randomised-double-blind-placebo-controlled-study
#4
Hisashi Yamanaka, Atsuo Taniguchi, Hiroshi Tsuboi, Hiroshi Kano, Yukio Asami
PURPOSE: Lactobacillus gasseri PA-3 (PA-3) has been previously shown to decrease serum uric acid (SUA) levels in subjects with increased SUA. In this study, we investigated whether PA-3 is also capable of decreasing SUA levels in patients with hyperuricaemia and/or gout. METHODS: Twenty-five patients with hyperuricaemia and/or gout completed this study. Urate-lowering drugs were discontinued for 12 weeks (week -4 to week 8). After flushing of urate-lowering drugs for 4 weeks (week 0), patients were randomised equally to receive diets containing yoghurt beverages with PA-3 or without PA-3 for a duration of 8 weeks (week 8)...
March 9, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29425155/markers-of-iron-status-are-associated-with-risk-of-hyperuricemia-among-chinese-adults-nationwide-population-based-study
#5
Xiangping Li, Tingchao He, Kai Yu, Qian Lu, Rashad Alkasir, Guifang Guo, Yong Xue
BACKGROUND: Elevated serum uric acid (SUA) involved in iron metabolism, has been increasingly recognized as a risk factor for gout and cardiovascular diseases. The objective of this study was to examine the associations between markers of iron status with risk of hyperuricemia (HU) in Chinese adult population. METHODS: Data were extracted from the 2009 wave of the China Health and Nutrition Survey, consisting of 7946 apparently healthy adults. Serum ferritin (SF), transferrin, soluble transferrin receptors (sTfR), hemoglobin (Hb), high-sensitivity C-reactive protein (hs-CRP), and SUA were measured...
February 9, 2018: Nutrients
https://www.readbyqxmd.com/read/29410028/mechanistic-insights-into-the-inhibition-of-quercetin-on-xanthine-oxidase
#6
Cen Zhang, Rui Wang, Guowen Zhang, Deming Gong
Quercetin, one of the most abundant flavonoid in the daily diet, was found to reversibly inhibit the generation of uric acid and superoxide radicals (O2 - )catalyzed by xanthine oxidase (XOD) in a mixed-type manner with IC50 values of (2.74±0.04)×10-6 and (2.90±0.03)×10-6 molL-1 , respectively, and the inhibition of quercetin on O2 - generation may be ascribed to the reduced form of XOD by a ping-pong mechanism. XOD had one high affinity binding site for quercetin with a binding constant of 4.28×104 Lmol-1 at 298K, and the binding process was predominately driven by van der Waals forces and hydrogen bonds on account of the negative enthalpy and entropy changes...
June 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29393086/uric-acid-the-unknown-uremic-toxin
#7
Alejandro Treviño-Becerra
This review brings together concepts of uric acid metabolism affecting renal parenchyma and its function and the current therapies to reduce hyperuricemia (HyU) and avoid renal disease progression. High uric acid plays an important role in several chronic diseases including kidney diseases such as lithiasis, gout nephropathy, and preeclampsia. In the last 30 years, it has been shown that reducing HyU with low protein and low purine diets in addition to allopurinol creates physiopathological conditions that produce a slight increase in the glomerular filtration rate (GFR)...
2018: Contributions to Nephrology
https://www.readbyqxmd.com/read/29342506/effects-of-a-dash-diet-intervention-on-serum-uric-acid-in-african-americans-with-hypertension
#8
Stephen P Juraschek, Karen White, Olive Tang, Hsin-Chieh Yeh, Lisa A Cooper, Edgar R Miller
OBJECTIVE: To examine whether partially replacing one's diet with DASH-related foods in the home environment lowered uric acid (SUA). METHODS: We conducted an ancillary study in a randomized trial of African Americans with controlled hypertension from an urban clinic. Participants were assigned to either a control or intervention (DASH-Plus) group. The control group received a DASH brochure and a debit account of $30/week to purchase foods. DASH-Plus participants received coach-directed dietary advice, assistance with purchasing DASH-related foods ($30/week), and home food delivery via a community supermarket...
January 17, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29115981/hyperuricemia-in-type-2-diabetic-model-kk-a-y-ta-mice-a-potent-animal-model-with-positive-correlation-between-insulin-resistance-and-plasma-high-uric-acid-levels
#9
Shin-Ichi Adachi, Fumiaki Yoshizawa, Kazumi Yagasaki
OBJECTIVE: Hyperuricemia is recognized as a main cause of gout. Accumulating clinical evidence suggests that hyperuricemia is strongly associated with insulin resistance and abnormal glucose metabolism. However, there seem no proper animal models for investigating such associations. Ideal animal model is considered to be hyperuricemic as well as diabetic. Selecting the KK-Ay /Ta mouse model, the relationship between hyperuricemia and insulin resistance has been studied to characterize such an animal model...
November 7, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29058239/low-purine-diet-is-more-effective-than-normal-purine-diet-in-reducing-the-risk-of-gouty-attacks-after-sleeve-gastrectomy-in-patients-suffering-of-gout-before-surgery-a-retrospective-study
#10
Luigi Schiavo, Guillaume Favrè, Vincenzo Pilone, Gianluca Rossetti, Gabriele De Sena, Antonio Iannelli, Alfonso Barbarisi
BACKGROUND: Obese patients with preoperative gout often suffer of gouty attacks after bariatric surgery (BS), probably due to the lack of an adequate postoperative diet. OBJECTIVES: The objectives of the study are to assess whether sleeve gastrectomy (SG) is effective in reducing the frequency of gouty attacks and also whether a postoperative low-purine diet (LPD) may further reduce these attacks as compared to a normal-purine diet (NPD) in a series of patients suffering of gout before SG...
October 23, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28975090/chronic-dietary-oxalate-nephropathy-after-intensive-dietary-weight-loss-regimen
#11
Gebran Khneizer, Ahmad Al-Taee, Meher S Mallick, Bahar Bastani
BACKGROUND: Hyperoxaluria has been associated with nephrolithiasis as well as acute and chronic kidney disease. We present a case of end stage renal failure caused by excessive dietary oxalate intake in a dietary weight loss regimen. CASE PRESENTATION: A 51-year-old Caucasian male with the past medical history of type 2 diabetes mellitus, gout, hypertension and morbid obesity was referred to the primary care clinic after being found pale and easily fatigued. The patient had lost 36 kg over a 7-month period by implementing exercise and intense dietary measures that included 6 meals of spinach, kale, berries, and nuts...
July 2017: Journal of Nephropathology
https://www.readbyqxmd.com/read/28915838/gout-and-comorbidity-a-nominal-group-study-of-people-with-gout
#12
Jasvinder A Singh
BACKGROUND: Comorbidities are common in patients with gout, yet qualitative research is lacking. The study objective was to examine the impact of gout on comorbidities. METHODS: Nine nominal groups were conducted. Patients with gout discussed and rank-ordered their concerns in response to the question, "How does gout or its treatment affect your other conditions and their treatment?" RESULTS: Nine nominal groups had 45 gout patients, with mean age 61 years (standard deviation (SD) 10...
September 15, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28866649/weight-loss-for-overweight-and-obese-individuals-with-gout-a-systematic-review-of-longitudinal-studies
#13
REVIEW
Sabrina M Nielsen, Else M Bartels, Marius Henriksen, Eva E Wæhrens, Henrik Gudbergsen, Henning Bliddal, Arne Astrup, Filip K Knop, Loreto Carmona, William J Taylor, Jasvinder A Singh, Fernando Perez-Ruiz, Lars E Kristensen, Robin Christensen
OBJECTIVES: Weight loss is commonly recommended for gout, but the magnitude of the effect has not been evaluated in a systematic review. The aim of this systematic review was to determine benefits and harms associated with weight loss in overweight and obese patients with gout. METHODS: We searched six databases for longitudinal studies, reporting the effect of weight loss in overweight/obese gout patients. Risk of bias was assessed using the tool Risk of Bias in Non-Randomised Studies of Interventions...
November 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28836797/an-illness-by-any-other-name-the-effect-of-renaming-gout-on-illness-and-treatment-perceptions
#14
Keith J Petrie, Kate MacKrill, Christina Derksen, Nicola Dalbeth
OBJECTIVE: Inaccurate lay views of an illness can lead to the adoption of unhelpful coping strategies and treatments. Gout is an example of an illness where the popular view of the condition conflicts with a modern understanding of the illness by overemphasizing the role of diet and alcohol in the development and management of the disease. In this study we investigated the effect of renaming gout as urate crystal arthritis on the perceptions of the illness. METHOD: One-hundred and 89 supermarket shoppers participated in a study examining the perceptions of different types of arthritis...
January 2018: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/28818081/what-makes-gouty-inflammation-so-variable
#15
REVIEW
Robert Terkeltaub
Acute gout arthritis flares contribute dominantly to gout-specific impaired health-related quality of life, representing a progressively increasing public health problem. Flares can be complex and expensive to treat, partly due to the frequent comorbidities. Unmet needs in gout management are more pressing given the markedly increasing gout flare hospital admission rates. In addition, chronic gouty arthritis can cause joint damage and functional impairment. This review addresses new knowledge on the basis for the marked, inherent variability of responses to deposited urate crystals, including the unpredictable and self-limited aspects of many gout flares...
August 18, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28748117/epidemiology-pathophysiology-and-management-of-uric-acid-urolithiasis-a-narrative-review
#16
REVIEW
A Abou-Elela
An in-depth comprehension of the epidemiology as well as pathophysiology of uric acid urolithiasis is important for the identification, treatment, and prophylaxis of calculi in these patients. Persistently low urinary pH, hyperuricosuria, and low urinary volume are the most important factors in pathogenesis of uric acid urolithiasis. Other various causes of calculus formation comprises of chronic diarrhea, renal hyperuricosuria, insulin resistance, primary gout, extra purine in the diet, neoplastic syndromes, and congenital hyperuricemia...
September 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28748116/gout-an-old-disease-in-new-perspective-a-review
#17
REVIEW
Gaafar Ragab, Mohsen Elshahaly, Thomas Bardin
Gout is a picturesque presentation of uric acid disturbance. It is the most well understood and described type of arthritis. Its epidemiology is studied. New insights into the pathophysiology of hyperuricemia and gouty arthritis; acute and chronic allow for an even better understanding of the disease. The role of genetic predisposition is becoming more evident. The clinical picture of gout is divided into asymptomatic hyperuricemia, acute gouty arthritis, intercritical period, and chronic tophaceous gout. Diagnosis is based on laboratory and radiological features...
September 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28745686/-effects-of-keto-amino-acids-and-a-low-protein-diet-on-the-nutritional-status-of-patients-with-stages-3b-4-chronic-kidney-disease
#18
S Yu Milovanova, Yu S Milovanov, M V Taranova, I A Dobrosmyslov
AIM: To evaluate the efficacy of keto/amino acids in maintaining protein balance and preventing mineral metabolic disturbances and the development of uremic hyperparathyroidism in the long-term use of a low-protein diet (LPD) in patients with Stages 3B-4 chronic kidney disease (CKD). SUBJECTS AND METHODS: Ninety patients with CKD caused by chronic latent glomerulonephritis in 65 patients and chronic tubulointerstitial nephritis of various etiologies (gout, drug-induced, and infection) in 25 were examined...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28490548/diet-high-in-vegetables-fruit-and-whole-grains-may-reduce-risk-of-gout
#19
Susan Mayor
No abstract text is available yet for this article.
May 9, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28487277/the-dietary-approaches-to-stop-hypertension-dash-diet-western-diet-and-risk-of-gout-in-men-prospective-cohort-study
#20
Sharan K Rai, Teresa T Fung, Na Lu, Sarah F Keller, Gary C Curhan, Hyon K Choi
Objective To prospectively examine the relation between the Dietary Approaches to Stop Hypertension (DASH) and Western diets and risk of gout (ie, the clinical endpoint of hyperuricemia) in men.Design Prospective cohort study.Setting The Health Professionals Follow-up Study.Participants 44 444 men with no history of gout at baseline. Using validated food frequency questionnaires, each participant was assigned a DASH dietary pattern score (based on high intake of fruits, vegetables, nuts and legumes, low fat dairy products, and whole grains, and low intake of sodium, sweetened beverages, and red and processed meats) and a Western dietary pattern score (based on high intake of red and processed meats, French fries, refined grains, sweets, and desserts)...
May 9, 2017: BMJ: British Medical Journal
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