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Diet and gout

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https://www.readbyqxmd.com/read/27906623/orotate-orotic-acid-an-essential-and-versatile-molecule
#1
M Löffler, E A Carrey, E Zameitat
Orotate (OA) is well-known as a precursor in biosynthesis of pyrimidines; in mammals it is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. OA is also a normal part of the diet, being found in milk and dairy products, and it is converted to uridine for use in the pyrimidine salvage pathway predominantly in liver, kidney and erythrocytes. Early research into nutrition identified orotate as "vitamin B13," and its use as a complex with organic cations or metal ions was promulgated in body-building, and in assisting therapies of metabolic syndromes...
December 2016: Nucleosides, Nucleotides & Nucleic Acids
https://www.readbyqxmd.com/read/27825577/efficacy-and-safety-of-febuxostat-in-73-gouty-patients-with-stage-4-5-chronic-kidney-disease-a-retrospective-study-of-10-centers
#2
Pierre-Antoine Juge, Marie-Elise Truchetet, Evangeline Pillebout, Sébastien Ottaviani, Cécile Vigneau, Clotilde Loustau, Divi Cornec, Tristan Pascart, Renaud Snanoudj, Florian Bailly, Emilie Cornec-Le Gall, Thierry Schaeverbeke, Alain Saraux, Philippe Dieudé, René-Marc Flipo, Pascal Richette, Frédéric Lioté, Thomas Bardin, Gérard Chalès, Hang-Korng Ea
OBJECTIVES: The allopurinol dose is limited in chronic kidney disease, particularly stage 4/5 chronic kidney disease. Febuxostat has a hepatic metabolism and has been approved without dose adaptation in gouty patients with stage 1-3 chronic kidney disease. We aimed to study the safety and efficacy of febuxostat for stage 4/5 chronic kidney disease. METHODS: In this retrospective study, we included patients with (1) a diagnosis of gout, (2) febuxostat treatment, (3) estimated glomerular filtration rate≤30mL/min/1...
November 4, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27749216/on-the-history-of-gout-paleopathological-evidences-from-the-medici-family-of-florence
#3
Valentina Giuffra, Simona Minozzi, Angelica Vitiello, Antonio Fornaciari
OBJECTIVES: Throughout history, gout has been referred to as the "disease of the kings", and has been clearly associated with the lifestyle of the aristocratic social classes. According to the written sources, several members of the famous Medici family of Florence suffered from an arthritic disease that contemporary physicians called "gout". A paleopathological study carried out on the skeletal remains of some members of the family, exhumed from their tombs in the Church of San Lorenzo in Florence, offered a unique opportunity to directly investigate the evidence of the arthritic diseases affecting this elite group...
September 7, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27729624/metabolic-syndrome-prevalence-and-risk-factors-in-korean-gout-patients
#4
Jae Hyun Jung, Gwan Gyu Song, Jong Dae Ji, Young Ho Lee, Jae-Hoon Kim, Young Ho Seo, Sung Jae Choi
Background/Aims: We performed this study to investigate associations between metabolic syndrome, chronic kidney disease (CKD), and gout. Methods: We reviewed the medical records of 151 patients with gout at the Department of Rheumatology in Korea University Ansan Hospital. The following measures were examined: waist circumference, blood pressure, alcohol consumption, and levels of triglyceride, high density lipoprotein cholesterol, fasting serum glucose, serum uric acid (SUA), creatinine, insulin, and C-peptide...
October 12, 2016: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/27722972/the-management-of-gout-in-different-clinical-specialties-in-turkey-a-patient-based-survey
#5
Mehmet Akif Öztürk, Rıdvan Mercan, Kevser Gök, Ahmet Mesut Onat, Bünyamin Kısacık, Gezmiş Kimyon, Ayşe Balkarlı, Arif Kaya, Veli Çobankara, Mehmet Ali Balcı, ÖmerNuri Pamuk, Gözde Yıldırım Çetin, Mehmet Sayarlıoğlu, Soner Şenel, Mehmet Engin Tezcan, Adem Küçük, Kemal Üreten, Şafak Şahin, Abdurrahman Tufan
Although gout is potentially curable, the management of this disease is often suboptimal. In this study, we investigated the treatment of gout in Turkey and also compared the management approaches to gout in different clinical specialties. Three hundred and nineteen consecutive patients (mean age 58.60 ± 12.8 years; 44 females, 275 males) were included in this multicenter study. A standardized form was generated to collect data about the patient's first admission to health care, the specialty of the doctor first diagnosed the gout, the treatment options for gout including attack management, patient referral, chronic treatment including medical treatment, and life style modifications...
October 8, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27666904/pathogenesis-and-clinical-management-of-gouty-arthritis
#6
Renu Saigal, Abhishek Agrawal
Gout, the most common of the crystal arthritides is a result of disturbed uric acid metabolism and precipitation of urate crystals in extra cellular space of joints, periarticular tissue, bones and other organs. In the West, gout affects around 1% of adult men over 45 years of age. The estimated incidence being 0.6 to 2.1 per 1000 per year, with a prevalence of 9.5 to 13.5 per 1000 persons of all ages.1 The incidence of gout has been on rise globally; potentially attributable to recent shifts in diet, lifestyle, medical care, and increased longevity...
December 2015: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27577288/a-healthy-diet-may-be-key-to-preventing-gout-flare-ups
#7
(no author information available yet)
Choosing the right foods can help manage gout. Avoiding saturated fats and concentrating on fruit, vegetables and low-fat dairy foods may be the most effective non-pharmacologic way to combat the gout, say researchers.
August 31, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27558643/overview-of-serum-uric-acid-treatment-targets-in-gout-why-less-than-6-mg-dl
#8
Gary Ruoff, N Lawrence Edwards
Gout is a progressive, painful, debilitating form of inflammatory arthritis. It is caused by factors that elevate the concentration of serum uric acid (sUA), leading to hyperuricemia (sUA >6.8 mg/dL). Continued elevated sUA can result in monosodium urate (MSU) crystal deposition in joints and soft tissues, and can cause acute and chronic inflammation. The prevalence of hyperuricemia and gout has increased over the last few decades, likely due to an aging population, changes in lifestyles and diet, and an increase in gout-associated comorbidities...
September 2016: Postgraduate Medicine
https://www.readbyqxmd.com/read/27528713/healthy-diet-could-prevent-gout-flares-study-finds
#9
Susan Mayor
No abstract text is available yet for this article.
2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27523583/effects-of-the-dietary-approaches-to-stop-hypertension-dash-diet-and-sodium-intake-on-serum-uric-acid
#10
Stephen P Juraschek, Allan C Gelber, Hyon K Choi, Lawrence J Appel, Edgar R Miller
OBJECTIVE: Randomized trial data guiding dietary recommendations to lower serum uric acid (SUA), the etiologic precursor of gout, are scarce. We examined the effects of the DASH diet (a well-established diet that lowers blood pressure) and levels of sodium intake, on SUA. METHODS: We conducted an ancillary study of a randomized, crossover feeding trial in 103 adults with pre- or stage 1 hypertension. Participants were randomly assigned to receive either the DASH diet or a control diet (typical of the average American diet) and were further fed low, medium, and high sodium levels for 30 days each in random order...
August 14, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27496979/dietary-fiber-and-the-short-chain-fatty-acid-acetate-promote-resolution-of-neutrophilic-inflammation-in-a-model-of-gout-in-mice
#11
Angélica T Vieira, Izabela Galvão, Laurence M Macia, Érica M Sernaglia, Marco Aurélio R Vinolo, Cristiana C Garcia, Luciana P Tavares, Flávio A Amaral, Lirlândia P Sousa, Flaviano S Martins, Charles R Mackay, Mauro M Teixeira
: Gout is a disease characterized by the deposition of monosodium urate (MSU) crystals in the joints. Continuous gout episodes may lead to unresolved inflammatory responses and tissue damage. We investigated the effects of a high-fiber diet and acetate, a short-chain fatty acid (SCFA) resulting from the metabolism of fiber by gut microbiota, on the inflammatory response in an experimental model of gout in mice. Injection of MSU crystals into the knee joint of mice induced neutrophil influx and inflammatory hypernociception...
August 5, 2016: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/27488444/obesity-and-urolithiasis-evidence-of-regional-influences
#12
Alberto Trinchieri, Emanuele Croppi, Emanuele Montanari
There is evidence that obese patients have an increased risk of renal stone formation, although this relationship could be less evident in some populations. The aim of this study was to evaluate the impact of overweight and obesity on the risk of renal stone formation in a population consuming a Mediterranean diet and to better elucidate the mechanisms underlying the increased risk of urolithiasis observed in obese subjects. We performed a retrospective review of 1698 stone forming patients (mean age 45.9 ± 14...
August 3, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27452679/update-on-importance-of-diet-in-gout
#13
Randall N Beyl, Laura Hughes, Sarah Morgan
Gout is an inflammatory arthritis caused by deposition of monosodium urate crystals within synovial joints. Although it is most well-known for its arthritis, gout has an intimate relationship with many other cardiovascular and metabolic conditions. Current recommendations support aggressive medical therapy to treat gout while dietary counseling has become less emphasized. This article argues for the absolute importance of dietary counseling in gout and proves why this counseling may impact the long term well-being of a patient with gout...
July 21, 2016: American Journal of Medicine
https://www.readbyqxmd.com/read/27324603/patients-with-gout-differ-from-healthy-subjects-in-renal-response-to-changes-in-serum-uric-acid
#14
Sha Liu, Fernando Perez-Ruiz, Jeffrey N Miner
OBJECTIVE: Our objectives were to determine whether a change in serum uric acid (sUA) resulted in a corresponding change in the fractional excretion of uric acid (FEUA) and whether the renal response was different in patients with gout versus healthy subjects. METHODS: FEUA was calculated from previously published studies and four new phase I studies in healthy subjects and/or patients with gout before and after treatment to lower or raise sUA. Treatments included xanthine oxidase inhibitors to lower sUA as well as infusion of uric acid and provision of a high-purine diet to raise sUA...
June 17, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27260408/juniperus-rigida-sieb-extract-inhibits-inflammatory-responses-via-attenuation-of-trif-dependent-signaling-and-inflammasome-activation
#15
Ji-Won Han, Do-Wan Shim, Woo-Young Shin, Myong-Ki Kim, Eun-Jeong Shim, Xiao Sun, Sushruta Koppula, Tack-Joong Kim, Tae-Bong Kang, Kwang-Ho Lee
ETHNOPHARMACOLOGICAL RELEVANCE: Juniperus rigida Sieb. (J. rigida) is used for medicinal purposes in Asian countries to treat inflammation-related disorders, such as neuralgia, dropsy, and gout. AIM OF THE STUDY: The anti-inflammatory effects of J. rigida extract (JR) and its underlying mechanisms were explored both in in vitro cell lines and in vivo metabolic disease models. MATERIAL AND METHODS: Lipopolysaccharide (LPS)-stimulated RAW264...
August 22, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27215179/lifestyle-and-dietary-habits-of-patients-with-gout-followed-in-rheumatology-settings
#16
M Manara, G Carrara, C A Scirè, M A Cimmino, M Govoni, C Montecucco, M Matucci-Cerinic, G Minisola, The King Study Group
Diet and lifestyles modification are core aspects of the non-pharmacological management of gout, but a poor consistency with suggested guidelines is reported. This study aimed to investigate dietary and lifestyle habits of patients with gout followed in rheumatology settings. Data were retrieved from the baseline dataset of the KING study, a multicentre cohort study of patients with gout followed in rheumatology settings. Dietary habits were assessed with the Italian National Institute of Statistics (ISTAT) food-frequency questionnaire and compared with reported data about general population...
2015: Reumatismo
https://www.readbyqxmd.com/read/27080363/determination-of-four-different-purines-and-their-changing-rules-in-seafood-by-high-performance-liquid-chromatography
#17
Xin Qu, Jianxin Sui, Nasha Mi, Hong Lin
BACKGROUND: Seafood is regarded as a high purine food that may induce gout, which has attracted extensive attentions about its safety. Therefore, the aim of this study was to develop a simple and reliable method to determine the purine content in seafood and its changing rules during storage to guide consumers with referenced content at different freshness. RESULTS: Chromatographic separation was carried out using Waters Atlantis dC18 column, and potassium phosphate monobasic solution (0...
April 15, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27008448/-nutritional-therapy-of-gout
#18
REVIEW
Beate Nickolai, Caroline Kiss
Nutrition and nutritional behaviours have been found to play a major role in the development of gout. Studies show that body mass index (BMI), as well as excessive intake of alcoholic beverages, meat, soft drinks and fruit juices increase the risk of developing gout. Similarly, dairy products and coffee have been seen to decrease the risk of hyperuricemia and gout, as they increase the excretion of uric acid. Flares of gout are often caused by large meals and high alcohol consumption. Each additional intake of meat portion per day increases the risk of gout by 21 %...
2016: Therapeutische Umschau. Revue Thérapeutique
https://www.readbyqxmd.com/read/26931313/a-cross-sectional-internet-based-patient-survey-of-the-management-strategies-for-gout
#19
Jasvinder A Singh, Nipam Shah, N Lawrence Edwards
BACKGROUND: Almost half of the patients with gout are not prescribed urate-lowering therapy (ULT) by their health care provider and >50 % use complementary and alternative therapies. Diet modification is popular among gout patients due to known associations of certain foods with gout flares. The interplay of the use of dietary supplements, diet modification, and ULT adherence in gout patients is not known. Despite the recent interest in diet and supplements, there are limited data on their use...
2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/26922820/-the-prevalence-of-hyperuricemia-in-xinjiang-kazaks-in-fuhaii
#20
Lijun Wu, Kuerbanjiang, Xiaoyun Song, Cainan Luo, Mikelayi, Gulina, Xinyan Meng, Muyasaier, Aiping Yuan, Li Zhang, Yufen Teng
OBJECTIVE: to investigate the prevalence of hyperuricemia (HUA) in Kazak population in Fuhai county, Xinjiang Aletai area. METHODS: A randomized cross-sectional cluster sampling was performed in Kazaks in Fuhai. A total of 2 006 inhabitants were investigated by household survey. The questionnaires were completed for general performance, past illness history and family history. Height, weight, body mass index (BMI) and blood pressure were measured and recorded. Fasting blood samples were collected for serum uric acid and other biochemical tests...
November 2015: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
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