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https://www.readbyqxmd.com/read/28817838/pharmacogenetic-determinants-of-outcomes-on-triplet-hepatic-artery-infusion-and-intravenous-cetuximab-for-liver-metastases-from-colorectal-cancer-european-trial-optiliv-nct00852228
#1
Francis Lévi, Abdoulaye Karaboué, Raphaël Saffroy, Christophe Desterke, Valerie Boige, Denis Smith, Mohamed Hebbar, Pasquale Innominato, Julien Taieb, Carlos Carvalho, Rosine Guimbaud, Christian Focan, Mohamed Bouchahda, René Adam, Michel Ducreux, Gérard Milano, Antoinette Lemoine
BACKGROUND: The hepatic artery infusion (HAI) of irinotecan, oxaliplatin and 5-fluorouracil with intravenous cetuximab achieved outstanding efficacy in previously treated patients with initially unresectable liver metastases from colorectal cancer. This planned study aimed at the identification of pharmacogenetic predictors of outcomes. METHODS: Circulating mononuclear cells were analysed for 207 single-nucleotide polymorphisms (SNPs) from 34 pharmacology genes...
August 17, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28809622/suicide-in-pretoria-a-retrospective-review-2007-2010
#2
Cornelia Engelbrecht, Ryan Blumenthal, Neil K Morris, Gert Saayman
BACKGROUND: The World Health Organization has declared suicide a global ealth crisis, predicting that ~1.53 million people will commit suicide annually by 2020. OBJECTIVE: A study from South Africa reviewed 1 018 suicide cases in Pretoria over 4 years (1997 - 2000). Our study was undertaken to establish whether there have been substantial changes in the profile of suicide victims who died in Pretoria a decade later. METHODS: Case records at the Pretoria Medico-Legal Laboratory were reviewed retrospectively from 2007 to 2010...
July 28, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28801267/primum-non-nocere-the-effects-of-sodium-hypochlorite-on-dentin-as-used-in-endodontics
#3
Li-Sha Gu, Xue-Qing Huang, Brandon Griffin, Brian R Bergeron, David H Pashley, Li-Na Niu, Franklin R Tay
The medical literature is replete with the maxim 'primum non nocere', cautioning health care providers to avoid doing any harm to human subjects in their delivery of medical care. Sodium hypochlorite (NaOCl) is a well-established irrigant for root canal treatment because of its antimicrobial and organic tissue remnant dissolution capability. However, little is known about the deleterious effect of this strong oxidizing agent on the integrity of human mineralized dentin. Iatrogenically-induced loss of dentin integrity may precipitate post-treatment root fracture and has potential medico-legal complications...
August 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28800757/anthelminthic-properties-of-methylene-chloride-methanol-1-1-extracts-of-two-cameroonians-medicinal-plants-on-heligmosomoides-bakeri-nematoda-heligmosomatidea
#4
Sergine Errole Ngouateu Teufack, Gertrude NMbogning Tayo, Marc Ngangout Alidou, Jeannette Yondo, Amely Frankline Djiomene, Josué Wabo Poné, Faùily Mpoame Mbida
BACKGROUND: The resistance of some medico-veterinary parasite strains as well as the unavailability and toxicity of synthetic anthelminthics on humans, animals and the impacts of their residues in the environment have pushed scientists to turn to plants with anthelminthic properties. Hence, the aim of this work was to contribute to the fight against helminths of medical and veterinary importance in general, and also to clear the environment of their free living stages. METHODS: Fresh eggs of Heligmosomoides bakeri were obtained from the faeces of experimentally infected mice...
August 11, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28799135/appendiceal-duplication-a-comprehensive-review-of-published-cases-and-clinical-recommendations
#5
H Nageswaran, U Khan, F Hill, A Maw
BACKGROUND: Duplex appendix is very rare (incidence 0.004%) but has clinical relevance given the frequency of appendicectomies performed. Failure to recognise duplication can result in failure of treatment and medico-legal consequences. A review of published cases was undertaken to identify factors that may help in managing this rare condition. METHODS: All English and non-English publications were identified in PubMed, Embase and Cochrane databases. Patient demographics, intraoperative findings, anatomical details and histopathology were analysed...
August 10, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28797531/-prevention-of-the-post-surgical-insatisfactions-and-possible-medico-legal-complications
#6
G Flageul, R Pessis
The purpose of this work is to better understand the reasons for post-surgical instability and what makes up the bed of medico-legal complications. Beyond technical competence, it is essential to observe a very high degree of rigor in listening to the real motivations in order to give the most accurate possible surgical indications and in particular to know to detect and never to operate certain patients who, whatever we do, will always be dissatisfied. The quality of information is one of the essential elements of prevention: information is part of the care and there is no therapeutic success without a successful relationship between a caregiver and a carereceiver...
August 7, 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/28793046/influence-of-the-tilt-angle-of-percutaneous-aortic-prosthesis-on-velocity-and-shear-stress-fields
#7
Bruno Alvares de Azevedo Gomes, Gabriel Cordeiro Camargo, Jorge Roberto Lopes Dos Santos, Luis Fernando Alzuguir Azevedo, Ângela Ourivio Nieckele, Aristarco Gonçalves Siqueira-Filho, Glaucia Maria Moraes de Oliveira
Background: Due to the nature of the percutaneous prosthesis deployment process, a variation in its final position is expected. Prosthetic valve placement will define the spatial location of its effective orifice in relation to the aortic annulus. The blood flow pattern in the ascending aorta is related to the aortic remodeling process, and depends on the spatial location of the effective orifice. The hemodynamic effect of small variations in the angle of inclination of the effective orifice has not been studied in detail...
August 7, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28793045/home-blood-pressure-monitoring-as-an-alternative-to-confirm-diagnoses-of-hypertension-in-adolescents-with-elevated-office-blood-pressure-from-a-brazilian-state-capital
#8
Thaís Inacio Rolim Póvoa, Thiago Veiga Jardim, Carolina de Souza Carneiro, Vanessa Roriz Ferreira, Karla Lorena Mendonça, Polyana Resende Silva de Morais, Flávia Miquetichuc Nogueira Nascente, Weimar Kunz Sebba Barroso de Souza, Ana Luiza Lima Sousa, Paulo César Brandão Veiga Jardim
Background: Regional differences of using home blood pressure monitoring (HBPM) as an alternative to ambulatory blood pressure monitoring (ABPM) in hypertensive adolescents are unknown. Objectives: Define if HBPM is an option to confirm diagnoses of hypertension in adolescents from a Brazilian capital with elevated office blood pressure (BP). Methods: Adolescents (12-18years) from public and private schools with BP > 90th percentile were studied to compare and evaluate the agreement among office BP measurements, HBPM and ambulatory BP monitoring...
August 7, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28781897/a-medicolegal-study-of-domestic-violence-in-south-region-of-jordan
#9
Hasan Al-Hawari, Asmaa El-Banna
BACKGROUND: Domestic violence is a forced pattern of behavior that happened in domestic settings to gain or maintain power and control over an individual. The aim of this work is to study the magnitude of domestic violence in south region of Jordan. METHODS: The retrospective study was retrieved from the medico-legal reports of domestic violence cases referred to the Directorate of Forensic Medicine in south region of Jordan during six years period starting from 1st of January 2010 till the end of December 2015...
2017: Egyptian journal of forensic sciences
https://www.readbyqxmd.com/read/28781784/prevalence-of-silent-breast-cancer-in-autopsy-specimens-as-studied-by-the-disease-being-held-by-image-guided-biopsies-the-pilot-study-and-literature-review
#10
Zacharoula Sidiropoulou, Ana Paula Vasconcelos, Cristiana Couceiro, Carlos Dos Santos, Ana Virginia Araújo, Inês Alegre, Claudia Santos, Filipa Costa, Vanessa Henriques, Carlos Neves, Fátima Cardoso, Pere Gascon
Breast cancer epidemiological patterns vary in European countries, which present different incidence rates. Data have suggested that the reduction in breast cancer mortality is not only due to the early detection of the disease, but is, in almost equal part, due to screening and to the advances that have been made in molecular medicine and the development of novel therapies. The aim of the present study is to quantify the actual number of cases of breast cancer present in both of the sexes by calculating the prevalence of silent breast cancer in corpses...
August 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28776380/is-cholecystectomy-the-treatment-of-choice-for-acute-acalculous-cholecystitis-a-systematic-review-of-the-literature
#11
Víctor Soria Aledo, Lorena Galindo Iñíguez, Diego Flores Funes, Milagros Carrasco Prats, Jose Luis Aguayo Albasini
BACKGROUND AND OBJECTIVES: There is currently no consensus with regard to the use of cholecystectomy or percutaneous cholecystostomy as the therapy of choice for acute acalculous cholecystitis. The goal of this study was to review the scientific evidence on the management of these patients according to clinical and radiographic findings. METHODS: A systematic review of the literature from 2000 to 2016 was performed. The databases of PubMed, Índice Médico Español, Cochrane Library and Embase were searched according to the following inclusion criteria: publication language (English or Spanish), adult patients, acalculous etiology and appropriate study design...
August 4, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28768366/semi-automatic-electronic-stent-register-a-novel-approach-to-preventing-ureteric-stents-lost-to-follow-up
#12
James W H Macneil, Peter Michail, Manish I Patel, Julie Ashbourne, Simon V Bariol, David A Ende, Tania A Hossack, Howard Lau, Audrey C Wang, Andrew J Brooks
BACKGROUND: Ureteric stents are indispensable tools in modern urology; however, the risk of them not being followed-up once inserted poses medical and medico-legal risks. Stent registers are a common solution to mitigate this risk; however, manual registers are logistically challenging, especially for busy units. METHODS: Western Sydney Local Health District developed a novel Semi-Automatic Electronic Stent Register (SAESR) utilizing billing information to track stent insertions...
August 2, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28767928/trends-in-the-prescription-of-clozapine-in-a-psychiatric-hospital-a-5-year-observational-study
#13
Gabriela Danielski Niehues, Alexandre Balestieri Balan, Vinicius Brum Prá, Raphaela Santos Pellizzaro, Paulo Roberto Antunes da Silva, Manuela Danielski Niehues, Ana Paula Costa, Marcelo Liborio Schwarzbold, Alexandre Paim Diaz
Introduction: Clozapine is a well-recognized effective treatment for some patients with treatment-resistant schizophrenia (TRS). Although it has potential benefits and approximately 30% of patients have a clinical indication for clozapine use, prescription rates are low. Objective: To evaluate clozapine prescription trends over a 5-year period in a tertiary psychiatric hospital. Methods: In this observational study, data prospectively collected by the Medical and Statistical File Service (Serviço de Arquivo Médico e Estatístico) and the Pharmacy Division of Instituto de Psiquiatria de Santa Catarina between January 2010 and December 2014 were summarized and analyzed by investigators blinded to data collection...
July 31, 2017: Trends in Psychiatry and Psychotherapy
https://www.readbyqxmd.com/read/28767921/hospitalization-costs-of-severe-bacterial-pneumonia-in-children-comparative-analysis-considering-different-costing-methods
#14
Sheila Elke Araujo Nunes, Ruth Minamisava, Maria Aparecida da Silva Vieira, Alexander Itria, Vicente Porfirio Pessoa, Ana Lúcia Sampaio Sgambatti de Andrade, Cristiana Maria Toscano
Objective: To determine and compare hospitalization costs of bacterial community-acquired pneumonia cases via different costing methods under the Brazilian Public Unified Health System perspective. Methods: Cost-of-illness study based on primary data collected from a sample of 59 children aged between 28 days and 35 months and hospitalized due to bacterial pneumonia. Direct medical and non-medical costs were considered and three costing methods employed: micro-costing based on medical record review, micro-costing based on therapeutic guidelines and gross-costing based on the Brazilian Public Unified Health System reimbursement rates...
April 2017: Einstein
https://www.readbyqxmd.com/read/28767908/work-addiction-and-quality-of-life-a-study-with-physicians
#15
Walter Fernandes de Azevedo, Lígia Andrade da Silva Telles Mathias
Objective: To evaluate the quality of life of physicians and investigate to what extent it is affected by work addiction. Methods: This is an exploratory, descriptive and cross-sectional study, conducted with 1,110 physicians. For data collection, we used a questionnaire with sociodemographic information, the World Health Organization Quality of Life BREF, and the Work Addiction Scale. Results: Most physicians presented high quality of life...
April 2017: Einstein
https://www.readbyqxmd.com/read/28764298/index-ring-finger-ratio-hand-and-foot-index-gender-estimation-tools
#16
Sonia Gupta, Vineeta Gupta, Nutan Tyagi, Ettishree, Sinthia Bhagat, Mohit Dadu, Nishita Anthwal, Tahira Ashraf
INTRODUCTION: Gender estimation from dismembered human body parts and skeletal remains in cases of mass disasters, explosions, and assaults cases is an imperative element of any medico-legal investigations and has been a major challenge for forensic scientists. AIM: The aim of the present study was to estimate the gender by using index and ring finger length ratio, hand and foot index along with the correlation of both the hand and foot index to determine the vital role of all the indices in establishing gender identity...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28763079/-medical-movement-in-mexico-to-50-years-open-file
#17
José Luis Sandoval-Gutiérrez
Gutiérrez-Samperio hace una excelente narrativa del movimiento denominado «blanco» hace medio siglo, encabezado por médicos y otros trabajadores de salud, principalmente enfermeras. Es importante revisar los logros y limitaciones que dicho fenómeno alcanzó. Por ejemplo, actualmente el residente que cursa una especialidad cuenta con un reconocimiento institucional, universitario y de profesiones al término de su formación, además de tener una beca económica (probablemente insuficiente) y días de vacaciones programados...
May 2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/28763077/-national-academy-of-medicine-one-hundred-and-fifty-four-academic-year
#18
Armando Mansilla-Olivares
El incalculable valor que atesora la Academia Nacional de Medicina, su enorme influencia y repercusión sobre la toma de decisiones médico-científico-epidemiológicas, radica única y exclusivamente en el dominio del conocimiento, la mente científica y el talento de todos y cada uno de sus miembros, desde su fundación en 1864 hasta nuestros días.
May 2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/28758801/using-medico-legal-data-to-investigate-fatal-older-road-user-crash-circumstances-and-risk-factors
#19
Sjaan Koppel, Lyndal Bugeja, Daisy Smith, Ashne Lamb, Jeremy Dwyer, Michael Fitzharris, Stuart Newstead, Angelo D'Elia, Judith Charlton
OBJECTIVE: This study used medico-legal data to investigate fatal older road user (ORU, aged 65 years and older) crash circumstances and risk factors relating to four key components of the Safe System approach (e.g., roads and roadsides, vehicles, road users and speeds) to identify areas of priority for targeted prevention activity. METHOD: The Coroners' Court of Victoria (CCOV)'s Surveillance Database was searched to identify and describe the frequency and rate per 100,000 population of fatal ORU crashes in the Australian state of Victoria for 2013-2014...
July 31, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28758063/acquired-systemic-to-pulmonary-venous-shunt-or-persistent-left-superior-vena-cava-a-rare-right-to-left-shunt-case-based-discussion
#20
Alexandre Gamet, Pascale Raud-Raynier, Thomas Kerforne, Stéphane Velasco, Luc Christiaens
Cardiac shunts are often described in congenital or pediatric populations, but systemic-to-pulmonary venous shunts in adult patients are reported in literature in isolated case reports. We present the case of a 70-year-old female with a left superior vena cava (SVC) draining into the left atrium by the left superior pulmonary vein, with a complete right-to-left shunt of the superior venous circulation caused by a former catheter thrombosis in the right SVC. Diagnosis was suspected after a contrast echocardiography showing an exclusive perfusion of left heart after intravenous injection and confirmed by helical computed tomography with three-dimensional reconstruction...
July 2017: Journal of Cardiovascular Echography
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