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Th2- type allergic diseases

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https://www.readbyqxmd.com/read/29331049/prenatal-maternal-psychosocial-stress-and-offspring-s-asthma-and-allergic-disease-a-systematic-review-and-meta-analysis
#1
Catherine Flanigan, Aziz Sheikh, Audrey DunnGalvin, Bronwyn K Brew, Catarina Almqvist, Bright I Nwaru
BACKGROUND: Prenatal maternal stress may influence offspring's atopic risk through sustained cortisol secretion resulting from activation of the hypothalamic-pituitary-axis (HPA), leading to Th2-biased cell differentiation in the fetus. We undertook a systematic review and meta-analysis investigating the relationship between prenatal maternal psychosocial stress and risk of asthma and allergy in the offspring. METHODS: We searched 11 electronic databases from 1960 to 2016, search the grey literature, and contacted experts in the field...
January 13, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29328030/modern-approaches-to-fractional-exhaled-nitric-oxide-as-a-useful-biomarker-for-allergic-asthma-phenotyping-and-management
#2
N Mgaloblishvili, M Gotua
Asthma is a pathologically heterogeneous disease, consisting of several phenotypes. Different types of airway inflammation are the cornerstone feature of this condition. Fraction of nitric oxide in exhaled air (FENO) has been proposed as a noninvasive, specific biomarker for eosinophilic airway inflammation and has been shown to be elevated in patients with allergic asthma phenotype. More recent studies indicate that FeNO identifies T-helper cell type 2 (Th2)-mediated airway inflammation with a high predictive value for identifying inhaled corticosteroid (ICS) responsive airway inflammation...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29313026/transcutaneous-pollinosis-immunotherapy-using-a-solid-in-oil-nanodispersion-system-carrying-t-cell-epitope-peptide-and-r848
#3
Momoko Kitaoka, Ayaka Naritomi, Yoshinori Kawabe, Masamichi Kamihira, Noriho Kamiya, Masahiro Goto
Antigen-specific immunotherapy is the only curative approach for the treatment of allergic diseases such as Japanese cedar pollinosis. Immunotherapy using a T cell epitope vaccine in combination with the adjuvant R848 is of particular interest as a safe and effective approach to treat allergic diseases. Herein, we propose a simple and easy to handle vaccine administration method using the original solid-in-oil (S/O) nanodispersion system that permeates through the skin. The S/O nanodispersion system is composed of nanoparticles of hydrophilic molecules surrounded with hydrophobic surfactants that are dispersed in an oil vehicle...
March 2017: Bioengineering & Translational Medicine
https://www.readbyqxmd.com/read/29302700/immunization-with-an-adenovirus-vectored-tb-vaccine-containing-ag85a-mtb32-effectively-alleviates-allergic-asthma
#4
Yiling Zhang, Ying Feng, Liang Li, Xianmiao Ye, Jinlin Wang, Qian Wang, Pingchao Li, Na Li, Xuehua Zheng, Xiang Gao, Chufang Li, Feng Li, Baoqing Sun, Kefang Lai, Zhong Su, Nanshan Zhong, Ling Chen, Liqiang Feng
Current treatments for allergic asthma primarily ameliorate symptoms rather than inhibit disease progression. Regulating the excessive T helper type 2 (Th2) responses may prevent asthma exacerbation. In this study, we investigated the protective effects of Ad5-gsgAM, an adenovirus vector carrying two mycobacterial antigens Ag85A and Mtb32, against allergic asthma. Using an ovalbumin (OVA)-induced asthmatic mouse model, we found that Ad5-gsgAM elicited much more Th1-biased CD4+T and CD8+T cells than bacillus Calmette-Guérin (BCG)...
January 4, 2018: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/29274414/lrp-1-attenuates-house-dust-mite-induced-eosinophilic-airway-inflammation-by-suppressing-dendritic-cell-mediated-adaptive-immune-responses
#5
Amarjit Mishra, Xianglan Yao, Ankit Saxena, Elizabeth M Gordon, Maryann Kaler, Rosemarie A Cuento, Amisha V Barochia, Pradeep K Dagur, J Philip McCoy, Karen J Keeran, Kenneth R Jeffries, Xuan Qu, Zu-Xi Yu, Stewart J Levine
BACKGROUND: The LDL-receptor related protein 1 (LRP-1) is a scavenger receptor that regulates adaptive immunity and inflammation. LRP-1 is not known to modulate the pathogenesis of allergic asthma. OBJECTIVE: To assess whether LRP-1 expression by dendritic cells (DCs) modulates adaptive immune responses in house dust mite (HDM)-induced airways disease. METHODS: LRP-1 expression on peripheral blood DCs was quantified by flow cytometry. The role of LRP-1 in modulating HDM-induced airways disease was assessed in mice with a deletion of LRP-1 in CD11c+ cells (Lrp1fl/fl; CD11c-Cre) and by the adoptive transfer of HDM-pulsed CD11b+ DCs from Lrp1fl/fl; CD11c-Cre mice to wild-type mice...
December 20, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29273402/an-algorithm-for-the-classification-of-mrna-patters-in-eosinophilic-esophagitis-integration-of-machine-learning
#6
Benjamin F Sallis, Lena Erkert, Sherezade Moñino-Romero, Utkucan Acar, Rina Wu, Liza Konnikova, Willem S Lexmond, Matthew J Hamilton, W Augustine Dunn, Zsolt Szepfalusi, Jon A Vanderhoof, Scott B Snapper, Jerrold R Turner, Jeffrey D Goldsmith, Lisa A Spencer, Samuel Nurko, Edda Fiebiger
BACKGROUND: Diagnostic evaluation of eosinophilic esophagitis (EoE) remains difficult, particularly the assessment of the patient's allergic status. OBJECTIVE: Establish an automated medical algorithm to assist in the evaluation of EoE. METHODS: Machine learning techniques were used to establish a diagnostic probability score for EoE (pEoE) based on esophageal mRNA transcript patterns from biopsies of patients with EoE, gastroesophageal reflux disease, and controls...
December 19, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29272985/the-expression-of-thymic-stromal-lymphopoietin-in-patients-and-animal-models-with-eosinophilic-otitis-media
#7
Tomoya Miura, Atsushi Matsubara, Naomi Kudo, Ryutaro Hara, Junko Takahata, Akira Sasaki
OBJECTIVE: In the present study, we aimed to clarify the expression of thymic stromal lymphopoietin (TSLP), a key trigger of Th2-type allergic disease, in the middle ear mucosa of eosinophilic otitis media (EOM). METHODS: An immunohistological study of TSLP was conducted in patients with EOM and in animal models of EOM constructed by intraperitoneal and intratympanic injection of ovalbumin for 7 and 14 days. In addition, the messenger RNA (mRNA) expression of TSLP in the middle ear mucosa of the animal models was analyzed using real-time PCR, and was compared with that of the control animals...
December 22, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29247993/interleukin-33-il-33-a-nuclear-cytokine-from-the-il-1-family
#8
REVIEW
Corinne Cayrol, Jean-Philippe Girard
Interleukin-33 (IL-33) is a tissue-derived nuclear cytokine from the IL-1 family abundantly expressed in endothelial cells, epithelial cells and fibroblast-like cells, both during homeostasis and inflammation. It functions as an alarm signal (alarmin) released upon cell injury or tissue damage to alert immune cells expressing the ST2 receptor (IL-1RL1). The major targets of IL-33 in vivo are tissue-resident immune cells such as mast cells, group 2 innate lymphoid cells (ILC2s) and regulatory T cells (Tregs)...
January 2018: Immunological Reviews
https://www.readbyqxmd.com/read/29232822/microglia-m2a-polarization-as-potential-link-between-food-allergy-and-autism-spectrum-disorders
#9
REVIEW
Hans O Kalkman, Dominik Feuerbach
Atopic diseases are frequently co-morbid with autism spectrum disorders (ASD). Allergic responses are associated with an activation of mast cells, innate lymphoid cells, and Th2 cells. These cells produce type-2 cytokines (IL4 and IL13), which stimulate microglia and macrophages to adopt a phenotype referred to as 'alternative activation' or 'M2A'. M2A-polarized macrophages and microglia play a physiological role in tissue repair by secreting growth factors such as brain-derived neurotrophic factor (BDNF) and insulin-like growth factor-1...
December 9, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/29221580/mechanisms-of-allergen-immunotherapy-for-inhaled-allergens-and-predictive-biomarkers
#10
REVIEW
Mohamed H Shamji, Stephen R Durham
Allergen immunotherapy is effective in patients with IgE-dependent allergic rhinitis and asthma. When immunotherapy is given continuously for 3 years, there is persistent clinical benefit for several years after its discontinuation. This disease-modifying effect is both antigen-specific and antigen-driven. Clinical improvement is accompanied by decreases in numbers of effector cells in target organs, including mast cells, basophils, eosinophils, and type 2 innate lymphoid cells. Immunotherapy results in the production of blocking IgG/IgG4 antibodies that can inhibit IgE-dependent activation mediated through both high-affinity IgE receptors (FcεRI) on mast cells and basophils and low-affinity IgE receptors (FcεRII) on B cells...
December 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29205464/interleukin-17-family-cytokines-in-protective-immunity-against-infections-role-of-hematopoietic-cell-derived-and-non-hematopoietic-cell-derived-interleukin-17s
#11
REVIEW
Goro Matsuzaki, Masayuki Umemura
Interleukin (IL)-17 family cytokines consisting of six members participate in immune response in infections, autoimmune diseases and inflammatory diseases. The prototype cytokine of the family, IL-17A, was originally identified from CD4+ T cells which are now termed Th17. Later IL-17A-producing cells are expanded to various hematopoietic cells including CD8+ T cells (Tc17), invariant NKT cells, γ δ T cells, non-T non-B lymphocytes termed type 3 innate lymphoid cells (ILC3), and neutrophils. Some members of the IL-17 family cytokines other than IL-17A were also expressed by CD4+ T cells: IL-17E by Th2 cells, and IL-17F by Th17 cells...
December 2, 2017: Microbiology and Immunology
https://www.readbyqxmd.com/read/29178680/t-helper-type-2-cells-direct-antigen-induced-eosinophilic-skin-inflammation-in-mice
#12
Osamu Kaminuma, Tomoe Nishimura, Noriko Kitamura, Mayumi Saeki, Takachika Hiroi, Akio Mori
Eosinophilic inflammation in combination with immunoglobulin E (IgE) production is a characteristic feature of atopic dermatitis. Although activated T-helper type (Th) 2 cells play critical roles in the local accumulation and activation of eosinophils, whether they induce eosinophilic skin inflammation, independent of the IgE-mediated pathway has been unclear. To address the functional role of T cells in allergic skin diseases, we herein transferred Th1/Th2-differentiated or naive DO11.10 T cells into unprimed BALB/c mice...
January 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29171126/coincidence-of-pollen-season-with-the-first-fetal-trimester-together-with-early-pet-exposure-is-associated-with-sensitisation-to-cat-and-dog-allergens-in-early-childhood-a-finnish-population-based-study
#13
Kaisa Pyrhönen, Petri Kulmala, Simo Näyhä
BACKGROUND: Children whose 11th fetal week falls in pollen season (spring) reportedly have an increased risk of sensitisation to food allergens. No such finding has been reported for pet allergens. OBJECTIVE: The aim of the study was to 1) evaluate the incidence of pet (dog and cat) sensitisation according to the season of the 11th fetal week and 2) whether the association between pet exposure and respective sensitisation is modified by the coincidence of the 11th fetal week with pollen season...
November 24, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29150715/interleukin-33-promotes-helper-t-cell-type-2-17-inflammation-in-children-with-allergic-rhinitis
#14
Yuanming Wang, Chuling Li, Xianglin Luo, Deyu Xu, Yaxiong Xu, Guanquan Li, Fang Liao, Shujuan Tan
OBJECTIVES: Interleukin-33 is a recently described cytokine which involved in helper T cell type-2 (Th2) mediated diseases. However, its regulatory effect in the pathogenesis of children allergic rhinitis (AR) needs to be further characterized. This study aims to evaluate the expression and role of IL-33 in children with AR. METHODS: Forty children with AR and twenty normal controls were included. IL-33 and Th cytokine production in serum and nasal lavage was examined by immunosorbent assay (ELISA), respectively...
November 17, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29124321/vaccine-responses-in-newborns
#15
REVIEW
Anja Saso, Beate Kampmann
Immunisation of the newborn represents a key global strategy in overcoming morbidity and mortality due to infection in early life. Potential limitations, however, include poor immunogenicity, safety concerns and the development of tolerogenicity or hypo-responsiveness to either the same antigen and/or concomitant antigens administered at birth or in the subsequent months. Furthermore, the neonatal immunological milieu is polarised towards Th2-type immunity with dampening of Th1-type responses and impaired humoral immunity, resulting in qualitatively and quantitatively poorer antibody responses compared to older infants...
November 9, 2017: Seminars in Immunopathology
https://www.readbyqxmd.com/read/29104649/small-interfering-rna-directed-against-microrna-155-delivered-by-a-lentiviral-vector-attenuates-asthmatic-features-in-a-mouse-model-of-allergic-asthma
#16
Huilong Chen, Xiangqin Xu, Sheng Cheng, Yuzhu Xu, Qi Xuefei, Yong Cao, Jungang Xie, Cong-Yi Wang, Yongjian Xu, Weining Xiong
Asthma is a chronic T helper type 2 (Th2) cell-mediated inflammatory disease characterized by airway hyperresponsiveness (AHR) and airway inflammation. Although the majority of patients with asthma can achieve a good level of control with existing treatments, asthma runs a chronic course and the effectiveness of current treatment is not satisfactory for certain patients. MicroRNAs (miRNAs) are short noncoding RNAs that suppress gene expression at the post-transcriptional level; their role in regulating allergic inflammation remains largely unknown...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29068539/eosinophil-persistence-in-vivo-and-sustained-viability-ex-vivo-in-response-to-respiratory-challenge-with-fungal-allergens
#17
Wendy E Geslewitz, Caroline M Percopo, Helene F Rosenberg
BACKGROUND: Eosinophils are immunomodulatory leukocytes that contribute to the pathogenesis of Th2 driven asthma and allergic lung diseases. OBJECTIVE: Our goal was to identify unique properties of eosinophils recruited to the lungs and airways of mice in response to challenge with asthma-associated fungal allergens. METHODS: Mice were challenged intranasally on days 0, 3 and 6 with a filtrate of Alternaria alternata. Recruited eosinophils were enumerated in bronchoalveolar lavage fluid...
October 25, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29057225/pathogenic-effector-th2-cells-in-allergic-eosinophilic-inflammatory-disease
#18
REVIEW
Alyssa Mitson-Salazar, Calman Prussin
There is an absolute requirement for Th2 cells in the pathogenesis of allergen-driven eosinophil-rich type 2 inflammation. Although Th2 cells are generally regarded as a homogeneous population, in the past decade there has been increasing evidence for a minority subpopulation of IL-5+ Th2 cells that have enhanced effector function. This IL-5+ Th2 subpopulation has been termed pathogenic effector Th2 (peTh2), as it exhibits greater effector function and disease association than conventional Th2 cells. peTh2 cells have a different expression profile, differentially express transcription factors, and preferentially use specific signaling pathways...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29055190/pinocembrin-attenuates-allergic-airway-inflammation-via-inhibition-of-nf-%C3%AE%C2%BAb-pathway-in-mice
#19
Xiaoyan Gu, Qian Zhang, Qiang Du, Hong Shen, Zhenghua Zhu
Pinocembrin, one of the primary flavonoids in propolis, possesses many biological activities, including anti-inflammation, anti-oxidation and immunoregulation. This study aimed to evaluate whether pinocembrin could attenuate ovalbumin (OVA)-induced allergic airway inflammation in mice and to explore the possible mechanism. BALB/c mice sensitized and challenged with OVA were administered intraperitoneally with pinocembrin. Airway inflammation and airway hyperresponsiveness were examined. T-helper type (Th) 2 cytokines in bronchoalveolar lavage fluid (BALF) and OVA-specific immunoglobulin E (IgE) in serum were determined...
October 18, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29038009/advances-in-mechanisms-of-allergic-disease-in-2016
#20
Marc E Rothenberg, Hirohisa Saito, R Stokes Peebles
This review highlights advances in mechanisms of allergic disease, particularly type 2 innate lymphoid cells; TH2 lymphocytes; eicosanoid regulation of inflammation; extracellular vesicles in allergic responses; IL-33; microbiome properties, especially as they relate to mucosal barrier function; and a series of findings concerning the allergic inflammatory cells eosinophils, basophils, and mast cells. During the last year, mechanistic advances occurred in understanding type 2 innate lymphoid cells, particularly related to their response to ozone, involvement with experimental food allergy responses, and regulation by IL-33...
October 13, 2017: Journal of Allergy and Clinical Immunology
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