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https://www.readbyqxmd.com/read/29689381/on-the-use-of-superparamagnetic-hydroxyapatite-nanoparticles-as-an-agent-for-magnetic-and-nuclear-in-vivo-imaging
#1
Alessio Adamiano, Michele Iafisco, Monica Sandri, Martina Basini, Paolo Arosio, Tamara Canu, Giovanni Sitia, Antonio Esposito, Vincenzo Iannotti, Giovanni Ausanio, Eirini Fragogeorgi, Maritina Rouchota, George Loudos, Alessandro Lascialfari, Anna Tampieri
The identification of alternative biocompatible magnetic NPs for advanced clinical application is becoming an important need due to raising concerns about iron accumulation in soft issues associated to the administration of superparamagnetic iron oxide nanoparticles (NPs). Here, we report on the performance of previously synthetized iron-doped hydroxyapatite (FeHA) NPs as contrast agent for magnetic resonance imaging (MRI). The MRI contrast abilities of FeHA and Endorem® (dextran coated iron oxide NPs) were assessed by 1 H nuclear magnetic resonance relaxometry and their performance in healthy mice was monitored by a 7 Tesla scanner...
April 21, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29667600/is-eye-lens-dosimetry-needed-in-nuclear-medicine
#2
Malgorzata Wrzesien, Leszek Krolicki, Lukasz Albiniak, Jerzy Olszewski
INTRODUCTION: The specificity of personnel exposure, which distinguishes nuclear medicine, is associated with the form of the radiation source used, and this often requires performing manual procedures while using radioactive isotopes. The variety of radionuclides and medical procedures, and the yearly increase in the number of patients, as well as the change of the individual dose limit for the lens of the eye from a value of 150 mSv per year to a level of 20 mSv, means that issues of eye lens routine dosimetry become interesting from the radiation protection point of view...
April 18, 2018: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29659390/combined-18f-fluoroethylcholine-pet-ct-and-99mtc-macroaggregated-albumin-spect-ct-predict-survival-in-patients-with-intermediate-stage-hepatocellular-carcinoma
#3
Markus Hartenbach, Stefan Weber, Magdalena Pilz, Sabrina Hartenbach, Mathias J Zacherl, Philipp M Paprottka, Reinhold Tiling, Peter Bartenstein, Marcus Hacker, Alexander R Haug, Nathalie L Albert
AIM: The aim of this study was to retrospectively analyze the prognostic value of combined Tc-macroaggregated albumin (MAA) SPECT/CT and [F]-fluoroethylcholine (FEC) PET/CT before radioembolization for survival of patients with intermediate-stage hepatocellular carcinoma. METHODS: Twenty-four patients with known hepatocellular carcinoma Barcelona Clinic Liver Cancer stage B were eligible for this analysis. All patients were scheduled for radioembolization and received a pretherapeutic [F]FEC PET/CT scan as well as Tc-MAA SPECT/CT for hepatopulmonary shunting...
April 13, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29659389/fdg-pet-ct-focal-uptake-on-an-ocular-prosthesis
#4
Alessandra Repetto, Carolina Igua, Pablo Sopena, Pilar Bello
We present a case of an unexpected focally increased radiotracer uptake in an artificial eye in an FDG-PET/CT scan that was performed on a woman with a history of choroidal melanoma. It is crucial to know the type of prosthesis used and the timing of replacement for a correct interpretation of the findings. Recently, an FDG PET/CT was proposed to monitor the vascularity of the prosthesis instead of gadolinium MRI or of Tc bone scintigraphy.
April 13, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29625755/-99m-technetium-based-prostate-specific-membrane-antigen-radioguided-surgery-in-recurrent-prostate-cancer
#5
Tobias Maurer, Stephanie Robu, Margret Schottelius, Kristina Schwamborn, Isabel Rauscher, Nynke S van den Berg, Fijs W B van Leeuwen, Bernhard Haller, Thomas Horn, Matthias M Heck, Jürgen E Gschwend, Markus Schwaiger, Hans-Jürgen Wester, Matthias Eiber
BACKGROUND: Prostate-specific membrane antigen (PSMA)-targeted positron emission tomography (PET) can visualize metastatic lesions in recurrent prostate cancer (PC). However, reliable identification of small and/or atypically localized lesions during salvage surgery procedures is challenging. OBJECTIVE: To describe the technique, feasibility, and short-term outcomes of99m Technetium (99m Tc)-based PSMA-radioguided surgery (99m Tc-PSMA-RGS) for removal of recurrent PC lesions...
April 3, 2018: European Urology
https://www.readbyqxmd.com/read/29592976/localisation-of-ectopic-mediastinal-parathyroid-adenoma-by-18f-fluorocholine-pet-ct
#6
Maria Triantafyllidou, Klaus Strobel, Alfred Leiser, Stefan Fischli
We report the case of two patients with newly diagnosed primary hyperparathyroidism: a 40-year-old woman during pregnancy and a 60-year-old man with initial hypercalcaemic crisis. In the first case, a bilateral neck exploration with parathyroidectomy during the second trimester of pregnancy was unsuccessful and the patient remained hypercalcaemic. Postpartum imaging assessment with technetium (99m Tc)-sestamibi scintigraphy could not supply conclusive diagnostic results. The use of18 F-fluorocholine (FCH) positron emission tomography (PET)/CT provided the accurate localisation of an ectopic parathyroid adenoma in the anterior mediastinum which was successfully resected by a thoracoscopic approach...
March 28, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29589208/significance-of-11-c-pib-pet-ct-in-cardiac-amyloidosis-compared-with-99m-tc-aprotinin-scintigraphy-a-pilot-study
#7
Ryogo Minamimoto, Toru Awaya, Kentaro Iwama, Masatoshi Hotta, Kazuhiko Nakajima, Risen Hirai, Osamu Okazaki, Yukio Hiroi
BACKGROUND: This study was to investigate the significance of 11 C-Pittsburgh B (PIB) PET/CT in patients with suspected cardiac amyloidosis compared with 99m Tc-aprotinin scintigraphy. METHODS: Thirteen consecutive patients with suspected cardiac amyloidosis were considered for enrolment in this prospective pilot study. Participants were scheduled to undergo a series of 11 C-PIB PET/CT and 99m Tc-aprotinin within a 2-month period. Finally, we evaluated nine cases who underwent both imaging modalities, and compared imaging results with clinical and pathological results and prognosis...
March 27, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29555989/prospective-evaluation-of-plasma-epstein-barr-virus-dna-clearance-and-fluorodeoxyglucose-positron-emission-scan-in-assessing-early-response-to-chemotherapy-in-patients-with-advanced-or-recurrent-nasopharyngeal-carcinoma
#8
Brigette Ma, Edwin P Hui, Ann King, Sing F Leung, Michael Km Kam, Frankie Mo, Leung Li, Ki Wang, Herbert Loong, Ashley Wong, Charles Ml Chan, K C Allen Chan, S C Cesar Wong, Y M Dennis Lo, Anthony Tc Chan
BACKGROUND: Plasma Epstein-Barr virus (pEBV) DNA and fluorodeoxyglucose positron emission (PET) reflect tumour burden in advanced NPC. This study hypothesised that a dual endpoint based on assessing pEBV DNA clearance and PET response could predict early drug response. METHODS: Eligible patients underwent a computed tomography (CT) scan and dual PET-CT at baseline, a PET-CT at 4 weeks, and then a CT scan at 10 weeks after starting palliative or induction chemotherapy...
March 20, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29550844/is-there-an-association-between-hibernating-myocardium-and-left-ventricular-mechanical-dyssynchrony-in-patients-with-myocardial-infarction
#9
Feifei Zhang, Wei Yang, Yuetao Wang, Haipeng Tang, Jianfeng Wang, Xiaoliang Shao, Ziyi Wang, Xiaoying Zhang, Ling Yang, Xiaosong Wang, Weihua Zhou
OBJECTIVE: Left ventricular mechanical dyssynchrony (LVMD) is an important factor in the prognosis of patients with myocardial infarction (MI). The aim of this study is to identify the influencing factors of LVMD in MI patients by radionuclide myocardial imaging. SUBJECTS AND METHODS: This study consisted of 91 patients who had a history of definite prior MI and underwent both technetium-99m methoxyisobutylisonitrile (99m Tc-MIBI) gated single photon emission tomography (SPET) myocardial perfusion imaging (MPI) and18 F-FDG positron emission tomography (PET) myocardial metabolic imaging...
March 20, 2018: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29545380/retrospective-voxel-based-dosimetry-for-assessing-the-body-surface-area-model-ability-to-predict-delivered-dose-and-radioembolization-outcome
#10
Marilyne Kafrouni, Carole Allimant, Marjolaine Fourcade, Sébastien Vauclin, Julien Delicque, Alina-Diana Ilonca, Boris Guiu, Federico Manna, Nicolas Molinari, Denis Mariano-Goulart, Fayçal Ben Bouallègue
The aim of this study was to quantitatively evaluate the body surface area (BSA) model ability to predict tumor absorbed dose and treatment outcome through retrospective voxel-based dosimetry. Methods: Data from thirty-five hepatocellular carcinoma patients with a total of forty-two resin microsphere radioembolization treatments were included. Injected activity was planned with the BSA model. Voxel dosimetry based on99m Tc-labeled macroaggregated albumin SPECT and90 Y-microsphere PET was retrospectively performed using a dedicated treatment planning system (PLANET® Dose, DOSIsoft SA, Cachan, France)...
March 15, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29538025/false-positive-results-in-18f-fluorocholine-pet-ct-for-a-thymoma-in-workup-of-a-hereditary-primary-hyperparathyroidism
#11
Léopoldine Bricaire, Capucine Richard, Mathieu Gauthé, Béatrix Cochand-Priollet, Sébastien Gaujoux
We present the case of a severe familial primary hyperparathyroidism related to a germline deletion in the HRPT2 (CDC73) gene. Morphological explorations revealed 2 potential hyperfunctioning parathyroid glands: a left cervical lesion on the neck ultrasound, and an ectopic mediastinal lesion on the parathyroid scintigraphy using Tc-methoxyisobutylisonitrile and on F-fluorocholine PET/CT. Surgery removal and histopathological examination determined that the mediastinal mass corresponded to a thymoma and the cervical lesion to a parathyroid adenoma...
March 13, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29517540/99mtc-methionine-hybrid-spect-ct-for-detection-of-recurrent-glioma-comparison-with-18f-fdg-pet-ct-and-contrast-enhanced-mri
#12
Geetanjali Arora, Punit Sharma, Anshul Sharma, Anil Kumar Mishra, Puja Panwar Hazari, Ahitagni Biswas, Ajay Garg, Deepak Aheer, Rakesh Kumar
OBJECTIVES: Posttherapy changes in treated glioma patients cannot be reliably differentiated from tumor recurrence. We evaluated the role of Tc-methionine SPECT/CT for the detection of recurrent glioma and compared the same with F-FDG PET/CT and contrast-enhanced MRI (CeMRI). METHODS: Forty-four patients with histologically proven, previously treated glioma and clinical suspicion of recurrence were prospectively enrolled in the study. Of these 44 patients, 39 (28 male and 11 female subjects; age, 38...
March 7, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29516131/-18-f-fluorocholine-pet-ct-in-the-assessment-of-primary-hyperparathyroidism-compared-with-99m-tc-mibi-or-99m-tc-tetrofosmin-spect-ct-a-prospective-dual-centre-study-in-100-patients
#13
Mohsen Beheshti, Lukas Hehenwarter, Zeinab Paymani, Gundula Rendl, Larisa Imamovic, Rupert Rettenbacher, Oleksiy Tsybrovskyy, Werner Langsteger, Christian Pirich
PURPOSE: In this prospective study we compared the accuracy of18 F-fluorocholine PET/CT with that of99m Tc-MIBI or99m Tc-tetrofosmin SPECT/CT in the preoperative detection of parathyroid adenoma in patients with primary hyperparathyroidism. We also assessed the value of semiquantitative parameters in differentiating between parathyroid hyperplasia and adenoma. METHODS: Both18 F-fluorocholine PET/CT and99m Tc-MIBI/tetrofosmin SPECT/CT were performed in 100 consecutive patients with biochemical evidence of primary hyperparathyroidism...
March 8, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29497956/comparison-of-99m-tc-3prgd-2-imaging-and-18-f-fdg-pet-ct-in-breast-cancer-and-expression-of-integrin-%C3%AE-v-%C3%AE-3-in-breast-cancer-vascular-endothelial-cells
#14
Zhenying Chen, Fangmeng Fu, Fang Li, Zhaohui Zhu, Yinghong Yang, Xiangjin Chen, Bing Jia, Shan Zheng, Chao Huang, Weibing Miao
PURPOSE: This study aimed to investigate the value of99m technetium-three polyethylene glycol spacers-arginine-glycine-aspartic acid ([99m Tc]3PRGD2 ) imaging in diagnosis and staging of breast cancer compared with 2-deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG) imaging, and to explore the expression of integrin αv β3 in tumor vascular endothelial cells. PROCEDURES: Forty-two women with suspected breast cancer underwent both [99m Tc]3PRGD2 imaging and [18 F]FDG imaging...
March 1, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29497801/first-validation-of-myocardial-flow-reserve-assessed-by-dynamic-99m-tc-sestamibi-czt-spect-camera-head-to-head-comparison-with-15-o-water-pet-and-fractional-flow-reserve-in-patients-with-suspected-coronary-artery-disease-the-waterday-study
#15
Denis Agostini, Vincent Roule, Catherine Nganoa, Nathaniel Roth, Raphael Baavour, Jean-Jacques Parienti, Farzin Beygui, Alain Manrique
PURPOSE: We assessed the feasibility of myocardial blood flow (MBF) and flow reserve (MFR) estimation using dynamic SPECT with a novel CZT camera in patients with stable CAD, in comparison with15 O-water PET and fractional flow reserve (FFR). METHODS: Thirty patients were prospectively included and underwent FFR measurements in the main coronary arteries (LAD, LCx, RCA). A stenosis ≥50% was considered obstructive and a FFR abnormal if ≤0.8. All patients underwent a dynamic rest/stress99m Tc-sestamibi CZT-SPECT and15 O-water PET for MBF and MFR calculation...
March 1, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29496402/methodology-of-the-18-f-fdg-pet-tc-cardiac-for-the-diagnosis-of-prosthetic-endocarditis-and-intracardiac-devices
#16
S Aguadé Bruix, A Roque Pérez, H Cuéllar Calabria, M N Pizzi
Infective endocarditis (IE) is a serious pathology with a poor prognosis, whose mortality has not changed significantly despite advances in its diagnosis and treatment in the last 30years. The diagnostic capacity of the modified Duke criteria in prosthetic endocarditis and/or devices does not exceed 50%, so new tools are necessary for the diagnosis of this entity in this context. The18 F-FDG PET/CTA combines a highly sensitive technique to detect inflammatory-infectious activity and a technique with high anatomical resolution to assess the structural lesions associated with endocarditis...
February 26, 2018: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/29447047/prospective-comparative-study-of-18-f-sodium-fluoride-pet-ct-and-planar-bone-scintigraphy-for-treatment-response-assessment-of-bone-metastases-in-patients-with-prostate-cancer
#17
Randi Fuglsang Fonager, Helle Damgaard Zacho, Niels Christian Langkilde, Joan Fledelius, June Anita Ejlersen, Helle Westergreen Hendel, Christian Haarmark, Mette Moe, Jesper Carl Mortensen, Mads Ryø Jochumsen, Lars Jelstrup Petersen
AIM: To compare18 F-sodium fluoride positron emission tomography/computed tomography (NaF PET/CT) and99m Tc-labelled diphosphonate bone scan (BS) for the monitoring of bone metastases in patients with prostate cancer undergoing anti-cancer treatment. MATERIAL AND METHODS: Data from 64 patients with prostate cancer were included. The patients received androgen-deprivation therapy (ADT), next-generation hormonal therapy (NGH) or chemotherapy. The patients had a baseline scan and 1-3 subsequent scans during six months of treatment...
February 15, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29371410/intra-individual-comparison-of-tc-99m-mdp-bone-scan-and-the-psma-ligand-tc-99m-mip-1427-in-patients-with-osseous-metastasized-prostate-cancer
#18
Hendrik Rathke, Ali Afshar-Oromieh, Frederik L Giesel, Christophe Kremer, Paul Flechsig, Sabine Haufe, Walter Mier, Tim Holland-Letz, Maximilian de Bucourt, Thomas Armor, John Babich, Uwe Haberkorn, Clemens Kratochwil
To evaluate the detection rate of bone metastases obtained with the PSMA targeting tracer 99m Tc-MIP-1427 as opposed to the conventional bone scan with 99m Tc-MDP in a collective of advanced stage patients with known osseous metastasized prostate cancer. Methods: 21 Patients with known metastatic disease were staged with both, conventional bone scan and PSMA-ligand scintigraphy, within a time-frame of <10 days. Imaging included planar whole-body scans and SPECT or SPECT/CT with two bed positions 3 h after injection of either 500-750 MBq 99m Tc-MIP-1427 or 600-750 MBq 99m Tc-MDP...
January 25, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29356735/flare-on-serial-prostate-specific-membrane-antigen-targeted-18f-dcfpyl-pet-ct-examinations-in-castration-resistant-prostate-cancer-first-observations
#19
Katherine A Zukotynski, John Valliant, François Bénard, Steven P Rowe, Chun K Kim, Martin G Pomper, Steve Y Cho
A 71-year-old man with castration-resistant prostate cancer demonstrated a flare phenomenon on Tc-MDP and CT after 10 weeks of enzalutamide. Prostate-specific membrane antigen-targeted F-DCFPyL PET/CT demonstrated minimal uptake at sites of baseline bone and lymph node disease with increasing uptake at sites of osseous disease following therapy. Although this is likely related in part to decreased androgen receptor activity and a consequent increase in prostate-specific membrane antigen expression, other mechanisms (neovascularization, cell infiltration from the bone repair process, osteoblastic turnover, or minimal radiotracer impurity) may also be involved in causing the increased F-DCFPyL uptake at sites of osseous flare...
March 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29340158/follicular-thyroid-cancer-avid-on-c-11-methionine-pet-ct
#20
Mads Ryø Jochumsen, Peter Iversen, Anne Kirstine Arveschoug
A case of follicular thyroid cancer with intense focal Methionine uptake on 11C-Methionine PET/CT is reported here. The use of 11C-Methionine PET in differentiated thyroid cancer is currently being investigated as a surrogate tracer compared to the more widely used 18F-FDG PET. This case illustrates the potential incremental value of this modality, not only in the localizing of parathyroid adenoma, but also indicating that 11C-Methionine PET might have a potential of increasing the pretest likelihood of thyroid malignancy in a cold nodule with highly increased Sestamibi uptake...
2018: Endocrinology, Diabetes & Metabolism Case Reports
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