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Adam Ali Ghotbi, Andreas Kjaer, Lars Nepper-Christensen, Kiril Aleksov Ahtarovski, Jacob Thomsen Lønborg, Niels Vejlstrup, Kasper Kyhl, Thomas Emil Christensen, Thomas Engstrøm, Henning Kelbæk, Lene Holmvang, Lia E Bang, Rasmus Sejersten Ripa, Philip Hasbak
BACKGROUND: Determining infarct size and myocardial salvage in patients with ST-segment elevation myocardial infarction (STEMI) is important when assessing the efficacy of new reperfusion strategies. We investigated whether rest (82)Rb-PET myocardial perfusion imaging can estimate area at risk, final infarct size, and myocardial salvage index when compared to cardiac SPECT and magnetic resonance (CMR). METHODS: Twelve STEMI patients were injected with (99m)Tc-Sestamibi intravenously immediate prior to reperfusion...
October 14, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Mélanie Gahier Penhoat, Delphine Drui, Catherine Ansquer, Eric Mirallie, Yves Maugars, Pascale Guillot
We report the case of a patient who presented with multiple brown tumors as the inaugural manifestation of primary hyperparathyroidism. Tc-99m hexakis methoxyisobutylisonitrile (99mTc-MIBI) scintigraphy demonstrated increased radiotracer uptake by the bone lesions. The patient was a 65-year-old male who sought advice for a swelling on his right shin. An osteolytic lesion was visible on the radiograph. A bone biopsy showed a benign tumor containing abundant osteoclastic cells. Laboratory abnormalities included hypercalcemia (3...
October 7, 2016: Joint, Bone, Spine: Revue du Rhumatisme
Ali Afshar-Oromieh, John W Babich, Clemens Kratochwil, Frederik L Giesel, Michael Eisenhut, Klaus Kopka, Uwe Haberkorn
The prostate-specific membrane antigen (PSMA) has received increased consideration during the past few years as an excellent target for both imaging and therapy of prostate cancer. After many years of outstanding preclinical research, the first significant step forward in clinical use was achieved in 2008 with the first human experience with the small-molecule PSMA inhibitors (123)I-MIP-1972 and (123)I-MIP-1095. A clinical breakthrough followed in 2011 with (68)Ga-PSMA-11 for PET imaging and (131)I-MIP-1095 for endoradiotherapy of metastatic prostate cancer...
October 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Jang Yoo, Hai-Jeon Yoon, Bom Sahn Kim
OBJECTIVE: This study aimed to evaluate the prognostic value of F-18 FDG PET/CT in comparison with Tc-99m sestamibi breast-specific gamma imaging (BSGI) and previously established clinical prognostic parameters of invasive ductal breast carcinoma (IDC). METHODS: We retrospectively included 157 female IDC patients (mean age 49.2 years, range 29.9-78.9) who underwent PET/CT and BSGI. The maximum standardized uptake value (SUVmax) and tumor to normal background ratios (TNRs) of their primary tumors were measured on PET/CT and BSGI, respectively...
September 19, 2016: Annals of Nuclear Medicine
Fleur M van der Valk, Simone L Verweij, Koos A H Zwinderman, Aart C Strang, Yannick Kaiser, Henk A Marquering, Aart J Nederveen, Erik S G Stroes, Hein J Verberne, James H F Rudd
OBJECTIVES: This study assessed 5 frequently applied arterial (18)fluorodeoxyglucose ((18)F-FDG) uptake metrics in healthy control subjects, those with risk factors and patients with cardiovascular disease (CVD), to derive uptake thresholds in each subject group. Additionally, we tested the reproducibility of these measures and produced recommended sample sizes for interventional drug studies. BACKGROUND: (18)F-FDG positron emission tomography (PET) can identify plaque inflammation as a surrogate endpoint for vascular interventional drug trials...
October 2016: JACC. Cardiovascular Imaging
Stephanie Robu, Margret Schottelius, Matthias Eiber, Tobias Maurer, Jürgen Gschwend, Markus Schwaiger, Hans-Jürgen Wester
: Initial studies in patients have demonstrated the suitability of (111)In-PSMA-I&T ((111)In-DOTAGA-(3-iodo-y)-f-k-Sub(KuE)) for radioguided surgery (RGS) of small metastatic prostate cancer (PCa) soft tissue lesions. To meet the clinical need for a more cost-effective alternative, the PSMA-I&T-based tracer concept was adapted to (99m)Tc-labeling chemistry. Two PSMA-I&T-derived inhibitors with all-L-serine- (MAS3) and all-D-serine- (mas3) chelating moieties were evaluated in parallel, and a kit procedure for routine (99m)Tc-labeling was developed...
September 15, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Ian S Negus, Robin B Holmes, Kirsty C Jordan, David A Nash, Gareth C Thorne, Margaret Saunders
PURPOSE: To make an adaptable, head shaped radionuclide phantom to simulate molecular imaging of the brain using clinical acquisition and reconstruction protocols. This will allow the characterization and correction of scanner characteristics, and improve the accuracy of clinical image analysis, including the application of databases of normal subjects. METHODS: A fused deposition modeling 3D printer was used to create a head shaped phantom made up of transaxial slabs, derived from a simulated MRI dataset...
September 2016: Medical Physics
Bailing Hsu, Lien-Hsin Hu, Bang-Hung Yang, Lung-Ching Chen, Yen-Kung Chen, Chien-Hsin Ting, Guang-Uei Hung, Wen-Sheng Huang, Tao-Cheng Wu
OBJECTIVES: The aim of this study was to evaluate the accuracy of myocardial blood flow (MBF) quantitation of (99m)Tc-Sestamibi (MIBI) single photon emission computed tomography (SPECT) compared with (13)N-Ammonia (NH3) position emission tomography (PET) on the same cohorts. BACKGROUND: Recent advances of SPECT technologies have been applied to develop MBF quantitation as a promising tool to diagnose coronary artery disease (CAD) for areas where PET MBF quantitation is not available...
September 1, 2016: European Journal of Nuclear Medicine and Molecular Imaging
Pierpaolo Alongi, Federico Caobelli, Roberta Gentile, Alessandro Stefano, Giorgio Russo, Domenico Albano, Sergio Baldari, Maria Carla Gilardi, Massimo Midiri
AIM: A small number of studies evaluated the detection rate of lesions from bladder carcinoma (BC) of 18 F-FDG PET/CT in the restaging process. However, the prognostic role of FDG PET/CT still remains unclear. The aim of the present study was to evaluate the accuracy, the effect upon treatment decision, and the prognostic value of FDG PET/CT in patients with suspected recurrent BC. MATERIALS AND METHODS: Forty-one patients affected by BC underwent FDG PET/CT for restaging purpose...
August 26, 2016: European Journal of Nuclear Medicine and Molecular Imaging
Yu-Ren Chen, Yu-Cheng Kuo, Cheng-Nan Hsu, Te-Chun Hsieh, Chia-Hung Kao
A 68-year-old man underwent serial F-FDG PET/CT scan follow-up for lung cancer. Then 5.5 years after the initial F-FDG PET/CT scan, the presumed benign bone tumor in the left clavicle showed markedly increased FDG uptake during follow-up; in contrast, the Tc-MDP bone scan paradoxically exhibited no apparent interval change since last bone scan 5.5 years earlier. He underwent a CT-guided biopsy, and the pathological diagnosis was benign fibrous histiocytoma. The result was consistent with the lack of progression in Tc-MDP bone scan, whereas the F-FDG PET/CT scan gave a false-positive impression of malignant transformation...
October 2016: Clinical Nuclear Medicine
Arun Sasikumar, Ajith Joy, Raviteja Nanabala, M R A Pillai, Hari T A
65-year-old man with left-sided pelvic pain on evaluation was found to have features suggestive of either Paget disease or prostatic bone metastasis of the left hemipelvis based on Tc-MDP bone scan and MRI. Ga-PSMA PET/CT to assess the possibility of primary prostate cancer and if present to stage it helped to rule out prostate cancer because of absence of focal abnormal increased tracer uptake in the prostate gland. However, false-positive tracer uptake was noted in the left hemipelvis, which was subject to biopsy and histopathologically proven to be Paget disease involvement...
October 2016: Clinical Nuclear Medicine
Michael S Hofman, Rodney J Hicks
Nuclear medicine renal imaging provides important functional data to assist in the diagnosis and management of patients with a variety of renal disorders. Physiologically stable metal chelates like ethylenediaminetetraacetic acid (EDTA) and diethylenetriamine penta-acetate (DTPA) are excreted by glomerular filtration and have been radiolabelled with a variety of isotopes for imaging glomerular filtration and quantitative assessment of glomerular filtration rate. Gallium-68 ((68)Ga) EDTA PET usage predates Technetium-99m ((99m)Tc) renal imaging, but virtually disappeared with the widespread adoption of gamma camera technology that was not optimal for imaging positron decay...
September 2016: Seminars in Nuclear Medicine
Gad Abikhzer, Saher Srour, Georgeta Fried, Karen Drumea, Ela Kozlener, Alex Frenkel, Ora Israel, Ignac Fogelman, Olga Kagna
OBJECTIVE: The superiority of sodium F-fluoride PET (F-PET)/computed tomography (CT) over planar and single field-of-view single-photon emission computed tomography (SPECT) bone scintigraphy with Tc-methylene diphosphonate in bone metastases detection has been established. The present study prospectively compares whole-body Tc-methylene diphosphonate SPECT (WB-SPECT) and F-PET performance indices for the detection of bone metastases in breast cancer. METHODS: A total of 41 pairs of studies in female breast cancer patients (average age 58 years, range 30-75) were included...
November 2016: Nuclear Medicine Communications
Qiufang Liu, Min Zhou, Panli Li, Geng Ku, Gang Huang, Chun Li, Shaoli Song
Determining sentinel lymph node (SLN) status is critical to cancer staging and treatment decisions. Currently, in clinical practice, (99m) Tc-radiocolloid-mediated planar scintigraphy and single-photon emission computed tomography (SPECT) are used to guide the biopsy and resection of SLNs. Recently, an emerging technique that combines positron emission tomography (PET) and photoacoustic tomography (PAT; PET-PAT) may offer accurate information in detecting SLNs. Herein, we report a kind of (64) CuS-labeled nanoparticle ((64) CuS-NP) for the detection of SLNs with PET-PAT...
August 15, 2016: Contrast Media & Molecular Imaging
Shumao Zhang, Yue Chen, Zhanwen Huang, Liang Cai, Yin Zhang
A 69-year-old man with a history of low back pain for more than 4 months underwent Tc-MDP bone scan to determine the cause of the symptoms. In addition to the osseous lesions, significant activity in the stomach wall was noted. However, a subsequent F-NaF PET/CT only revealed bone lesion without increased activity in the stomach wall. The cause of the back pain was eventually confirmed due to multiple myeloma.
September 2016: Clinical Nuclear Medicine
Sandip Basu, Amit Joshi
We describe somatostatin receptor targeted imaging findings in a 56-year-old woman with elevated serum thyroglobulin and radioiodine negative DTC fibular metastasis. The fibular lesion was biopsy proven of poorly differentiated thyroid carcinoma and demonstrated high grade uptake on Tc-HYNIC-TOC scintigraphy. She opted for sorafenib therapy for progressively increasing fibular swelling and was started on 400 mg daily followed by dose escalation to 400 mg twice daily. At 17 months after sorafenib initiation, Ga DOTATATE PET/CT demonstrated necrosis of the fibular lesion; however, new lesions were documented in lower dorsal and lumbar vertebrae and skull, based upon which sorafenib withdrawal was contemplated...
October 2016: Clinical Nuclear Medicine
Naoko Nose, Kazuhito Fukushima, Constantin Lapa, Rudolf A Werner, Mehrbod Som Javadi, Junichi Taki, Takahiro Higuchi
UNLABELLED: Coronary flow reserve (CFR), defined as the ratio of maximum coronary flow increase from baseline resting blood flow, is one of the most sensitive parameters to detect early signs of coronary arteriosclerosis at the microvascular level. Myocardial perfusion PET is a well-established technology for CFR measurement, however, availability is still limited. The aim of this study is to introduce and validate myocardial flow reserve measurement by myocardial perfusion SPECT. METHODS: Myocardial perfusion SPECT at rest and ATP stress (0...
November 1, 2016: International Journal of Cardiology
Li Chen, Yue Chen, Zhanwen Huang, Liang Cai, He Huang
A 64-year-old woman with a newly diagnosed left breast cancer underwent a presurgical Tc-MDP whole-body imaging, which showed 1 intense activity in the midline upper abdomen and another overlapping the upper thoracic spine. An F-NaF PET/CT scan performed a day later also revealed the elevated activity in the same regions. The activity corresponded to calcified subcutaneous implants, which were placed there more than 30 years ago.
October 2016: Clinical Nuclear Medicine
Xiaona Jin, Naixin Liang, Mengzhao Wang, Yunxiao Meng, Bing Jia, Ximin Shi, Shanqing Li, Jinmei Luo, Yaping Luo, Quancai Cui, Kun Zheng, Zhaofei Liu, Jiyun Shi, Fang Li, Fan Wang, Zhaohui Zhu
Purpose To evaluate an integrin imaging approach based on single photon emission computed tomography (SPECT)/computed tomography (CT) by using technetium 99m ((99m)Tc)-dimeric cyclic arginine-glycine-aspartic acid (RGD) peptides with three polyethylene glycol spacers (3PRGD2) as the tracer to target the integrin αvβ3 expression in lung cancer and lymph node metastasis. Materials and Methods With ethics committee approval and written informed consent, 65 patients (41 male, 24 female; mean age, 60 years ± 11 [standard deviation]) with suspicious lung lesions were recruited with informed consent...
July 29, 2016: Radiology
Emma Matilda Mellhammar, Magnus Dahlbom, Johan Axelsson, Sven-Erik Strand
: Positron emission tomography (PET) may provide important information on the therapeutic response of radiopharmaceutical therapy (RPT) during therapy. The radiation emission from the RPT radionuclide may disturb the coincidence detection and impair the image resolution. In this study we tested the feasibility to perform intratherapeutic PET on three preclinical PET systems. METHODS: Using (22)Na point sources and phantoms filled with (18)F, and a phantom filled with either (99m)Tc or (177)Lu, the coincidence count rate and the spatial resolution when both a PET and a therapeutic radionuclide were present in the PET camera, were evaluated...
July 28, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
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