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https://www.readbyqxmd.com/read/27908147/strategies-for-ct-tissue-segmentation-for-monte-carlo-calculations-in-nuclear-medicine-dosimetry
#1
P E N Braad, T Andersen, S B Hansen, P F Høilund-Carlsen
PURPOSE: CT images are used for patient specific Monte Carlo treatment planning in radionuclide therapy. The authors investigated the impact of tissue classification, CT image segmentation, and CT errors on Monte Carlo calculated absorbed dose estimates in nuclear medicine. METHODS: CT errors as a function of patient size, CT reconstruction, and tube current modulation methods were assessed in a phantom experiment on a clinical CT system. The impact of tissue segmentation methods and CT number variations on EGSnrc Monte Carlo calculated absorbed dose distributions was assessed for (99m)Tc and (131)I in the ICRP/ICRU male phantom and in a patient PET/CT-scanned with (124)I prior to radioiodine therapy...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27890514/effectiveness-of-radiolabelled-somatostatin-analogues-90-y-dotatoc-and-177-lu-dotatate-in-patients-with-metastatic-neuroendocrine-tumours-a-single-centre-experience-in-mexico
#2
S S Medina-Ornelas, F O García-Pérez
OBJECTIVE: To determine the effectiveness of therapy with the radiolabelled somatostatin analogues, (90)Y-DOTATOC and (177)Lu-DOTATATE, in the treatment of metastatic neuroendocrine tumours with progression to first-line treatment. MATERIAL AND METHODS: A study was conducted on 30 patients diagnosed with neuroendocrine tumours (gastroenteropancreatic, bronchopulmonary, MEN2A, MEN2B, phaeochromocytoma, and paraganglioma) with metastatic disease diagnosed by the pathology department, with progression to first-line treatment, and recruited from December 2014 to February 2016...
November 24, 2016: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/27885455/-psma-radioguided-surgery-in-localized-recurrent-prostate-cancer-current-and-future-aspects
#3
I Rauscher, M Eiber, C A Jilg, J E Gschwend, T Maurer
Recently, PSMA-radioguided surgery (PSMA-RGS) was introduced for targeted resection of localized prostate cancer recurrence. Prerequisite for preoperative patient selection and localization of tumor recurrence is a positive (68)Ga-HBED-CC PSMA positron emission tomography (PET) scan with preferably only singular soft tissue or lymph node recurrence. After injection of In-PSMA I&T or Tc-PSMA-I&S single photon emission computer tomography (SPECT)/computer tomography (CT) examination is performed in every patient to verify radiotracer uptake in tumor lesions...
November 24, 2016: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/27879491/18f-fdg-pet-ct-in-renal-infections-evidence-of-acute-pyelonephritis-in-a-horseshoe-kidney
#4
Maxime Morelle, Alice Jaillard, Dimitri Bellevre, Guillaume Collet, Grégory Petyt
A 58-year-old paraplegic patient was prescribed F-FDG for persistent inflammatory syndrome after aortic surgery for dissection. The examination was performed on a Siemens mCT Flow PET/CT and shows a moderate prostate uptake, related to prostatitis on self-catheterization and a focal renal cortical hypermetabolism of the left medial midpole of a horseshoe kidney, which corresponds to renal parenchyma on the CT, and suggests pyelonephritis, confirmed by Tc-DMSA SPECT/CT.
November 22, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27879368/99mtc-duramycin-spect-imaging-of-early-tumor-response-to-targeted-therapy-a-comparison-with-18f-fdg-pet
#5
Filipe Elvas, Jan Boddaert, Christel Vangestel, Koon Pak, Brian Gray, Samir Kumar-Singh, Steven Staelens, Sigrid Stroobants, Leonie Wyffels
: Molecular imaging of cell death may provide a detailed readout of the cellular response to novel therapies and prognostic information on tumor treatment efficacy assisting in the design of individualized therapy. We compared the predictive power of cell death imaging using (99m)Tc-duramycin to current gold standard (18)F-FDG for treatment response evaluation after targeted therapy. METHODS: Early therapy response evaluation was assessed by (99m)Tc-duramycin SPECT and (18)F-FDG PET imaging in treatment-sensitive COLO205 and treatment-resistant HT29 human colorectal cancer xenografts 24 hours after a single dose of conatumumab or IgG1 control...
November 22, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27834016/is-c-11-methionine-pet-ct-able-to-localise-sestamibi-negative-parathyroid-adenomas
#6
Theresia Weber, Martin Gottstein, Sabrina Schwenzer, Ambros Beer, Markus Luster
BACKGROUND: Patients with primary hyperparathyroidism (pHPT) and a negative preoperative Tc-99 sestamibi (MIBI) scintigraphy are considered to have a higher risk of persistent disease. The aim of this study was to assess whether additional imaging with C-11 methionine positron emission tomography/computed tomography (Met-PET/CT) is able to localise sestamibi-negative hyperfunctioning parathyroid glands. METHODS: In 50 patients (38 females, 12 males, age 13-81 years) with pHPT and negative localisation procedures such as ultrasound and sestamibi, a Met-PET/CT was performed before parathyroid surgery...
November 10, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27825429/-18-f-naf-pet-ct-and-99m-tc-mdp-bone-scintigraphy-in-the-detection-of-bone-metastases-in-prostate-cancer
#7
REVIEW
Werner Langsteger, Alireza Rezaee, Christian Pirich, Mohsen Beheshti
(99m)Tc-MDP whole-body bone scintigraphy is a highly sensitive imaging method that has been used for decades to evaluate prostate cancer bone metastasis based on its availability and low cost; however, because of accumulation of this radiotracer in degenerative, traumatic, and inflammatory lesions, it suffers from noncomparable specificity. The modality is also used to monitor response to therapy and to predict patients' prognosis. As planar imaging may not give enough information for lesion detection or anatomical localization, it can be supplemented with SPECT to increase image contrast particularly in the evaluation of small and complex skeleton...
November 2016: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/27824326/99mtc-sestamibi-avid-soft-tissue-lesions-in-rosai-dorfman-disease
#8
Philip Kin-Wai Wong, Daniel J Lee, Saul Harari, Bruce J Barron
Langerhan's histiocytosis is a not uncommon disease, but a related disorder, Rosai-Dorfman (RDD) with extensive or exclusive extranodal distribution, is relatively rare. Ga and PET/CT imaging have typically been used for diagnosis and tracking response to treatment. The authors present a very unusual case wherein lesions of RDD actively accumulated Tc-sestamibi, which was injected as part of a scan to localize a parathyroid adenoma.
December 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27821344/nuclear-data-for-production-and-medical-application-of-radionuclides-present-status-and-future-needs
#9
REVIEW
Syed M Qaim
INTRODUCTION: The significance of nuclear data in the choice and medical application of a radionuclide is considered: the decay data determine its suitability for organ imaging or internal therapy and the reaction cross section data allow optimisation of its production route. A brief discussion of reaction cross sections and yields is given. STANDARD RADIONUCLIDES: The standard SPECT, PET and therapeutic radionuclides are enumerated and their decay and production data are considered...
September 2, 2016: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/27809936/impact-of-combined-fdg-pet-ct-and-mri-on-the-detection-of-local-recurrence-and-nodal-metastases-in-thyroid-cancer
#10
Johann-Martin Hempel, Roman Kloeckner, Sandra Krick, Daniel Pinto Dos Santos, Simin Schadmand-Fischer, Patrick Boeßert, Sotirios Bisdas, Matthias M Weber, Christian Fottner, Thomas J Musholt, Mathias Schreckenberger, Matthias Miederer
BACKGROUND: Suspected recurrence of thyroid carcinoma is a diagnostic challenge when findings of both a radio iodine whole body scan and ultrasound are negative. PET/CT and MRI have shown to be feasible for detection of recurrent disease. However, the added value of a consensus reading by the radiologist and the nuclear medicine physician, which has been deemed to be helpful in clinical routines, has not been investigated. This study aimed to investigate the impact of combined FDG-PET/ldCT and MRI on detection of locally recurrent TC and nodal metastases in high-risk patients with special focus on the value of the multidisciplinary consensus reading...
November 3, 2016: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/27804855/the-thyroid-ultrasound-and-other-imaging-procedures-in-the-pediatric-age
#11
Claudio Spinelli, Federica Guidoccio, Mariano Grosso
The purpose of this review is to provide a reappraisal of the diagnostic imaging procedures for thyroid carcinoma in pediatric patients, including thyroid ultrasound (US), ultrasound-guided fine-needle aspiration biopsy (FNAB), scintigraphy, radiological techniques (CT, MR), and PET/CT. The most frequent indication for thyroid imaging is characterization of a palpable mass in the neck or thyroid gland. Thyroid US is a first-line examination for visualizing the thyroid gland as it provides anatomic and perfusion information; on the other hand, scintigraphy mostly provides functional information but combined with some anatomic information as well...
October 31, 2016: Current Pediatric Reviews
https://www.readbyqxmd.com/read/27743299/subacute-cardiac-rubidium-82-positron-emission-tomography-82-rb-pet-to-assess-myocardial-area-at-risk-final-infarct-size-and-myocardial-salvage-after-stemi
#12
Adam Ali Ghotbi, Andreas Kjaer, Lars Nepper-Christensen, Kiril Aleksov Ahtarovski, Jacob Thomsen Lønborg, Niels Vejlstrup, Kasper Kyhl, Thomas Emil Christensen, Thomas Engstrøm, Henning Kelbæk, Lene Holmvang, Lia E Bang, Rasmus Sejersten Ripa, Philip Hasbak
BACKGROUND: Determining infarct size and myocardial salvage in patients with ST-segment elevation myocardial infarction (STEMI) is important when assessing the efficacy of new reperfusion strategies. We investigated whether rest (82)Rb-PET myocardial perfusion imaging can estimate area at risk, final infarct size, and myocardial salvage index when compared to cardiac SPECT and magnetic resonance (CMR). METHODS: Twelve STEMI patients were injected with (99m)Tc-Sestamibi intravenously immediate prior to reperfusion...
October 14, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27726929/contribution-of-18-fdg-pet-ct-to-brown-tumor-detection-in-a-patient-with-primary-hyperparathyroidism
#13
Mélanie Gahier Penhoat, Delphine Drui, Catherine Ansquer, Eric Mirallie, Yves Maugars, Pascale Guillot
We report the case of a patient who presented with multiple brown tumors as the inaugural manifestation of primary hyperparathyroidism. Tc-99m hexakis methoxyisobutylisonitrile (99mTc-MIBI) scintigraphy demonstrated increased radiotracer uptake by the bone lesions. The patient was a 65-year-old male who sought advice for a swelling on his right shin. An osteolytic lesion was visible on the radiograph. A bone biopsy showed a benign tumor containing abundant osteoclastic cells. Laboratory abnormalities included hypercalcemia (3...
October 7, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27694178/the-rise-of-psma-ligands-for-diagnosis-and-therapy-of-prostate-cancer
#14
Ali Afshar-Oromieh, John W Babich, Clemens Kratochwil, Frederik L Giesel, Michael Eisenhut, Klaus Kopka, Uwe Haberkorn
The prostate-specific membrane antigen (PSMA) has received increased consideration during the past few years as an excellent target for both imaging and therapy of prostate cancer. After many years of outstanding preclinical research, the first significant step forward in clinical use was achieved in 2008 with the first human experience with the small-molecule PSMA inhibitors (123)I-MIP-1972 and (123)I-MIP-1095. A clinical breakthrough followed in 2011 with (68)Ga-PSMA-11 for PET imaging and (131)I-MIP-1095 for endoradiotherapy of metastatic prostate cancer...
October 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27645144/prognostic-value-of-primary-tumor-suvmax-on-f-18-fdg-pet-ct-compared-with-semi-quantitative-tumor-uptake-on-tc-99m-sestamibi-breast-specific-gamma-imaging-in-invasive-ductal-breast-cancer
#15
Jang Yoo, Hai-Jeon Yoon, Bom Sahn Kim
OBJECTIVE: This study aimed to evaluate the prognostic value of F-18 FDG PET/CT in comparison with Tc-99m sestamibi breast-specific gamma imaging (BSGI) and previously established clinical prognostic parameters of invasive ductal breast carcinoma (IDC). METHODS: We retrospectively included 157 female IDC patients (mean age 49.2 years, range 29.9-78.9) who underwent PET/CT and BSGI. The maximum standardized uptake value (SUVmax) and tumor to normal background ratios (TNRs) of their primary tumors were measured on PET/CT and BSGI, respectively...
September 19, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27639759/thresholds-for-arterial-wall-inflammation-quantified-by-18-f-fdg-pet-imaging-implications-for-vascular-interventional-studies
#16
Fleur M van der Valk, Simone L Verweij, Koos A H Zwinderman, Aart C Strang, Yannick Kaiser, Henk A Marquering, Aart J Nederveen, Erik S G Stroes, Hein J Verberne, James H F Rudd
OBJECTIVES: This study assessed 5 frequently applied arterial (18)fluorodeoxyglucose ((18)F-FDG) uptake metrics in healthy control subjects, those with risk factors and patients with cardiovascular disease (CVD), to derive uptake thresholds in each subject group. Additionally, we tested the reproducibility of these measures and produced recommended sample sizes for interventional drug studies. BACKGROUND: (18)F-FDG positron emission tomography (PET) can identify plaque inflammation as a surrogate endpoint for vascular interventional drug trials...
October 2016: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27635024/preclinical-evaluation-and-first-patient-application-of-99mtc-psma-i-s-for-spect-imaging-and-radioguided-surgery-in-prostate-cancer
#17
Stephanie Robu, Margret Schottelius, Matthias Eiber, Tobias Maurer, Jürgen Gschwend, Markus Schwaiger, Hans-Jürgen Wester
: Initial studies in patients have demonstrated the suitability of (111)In-PSMA-I&T ((111)In-DOTAGA-(3-iodo-y)-f-k-Sub(KuE)) for radioguided surgery (RGS) of small metastatic prostate cancer (PCa) soft tissue lesions. To meet the clinical need for a more cost-effective alternative, the PSMA-I&T-based tracer concept was adapted to (99m)Tc-labeling chemistry. Two PSMA-I&T-derived inhibitors with all-L-serine- (MAS3) and all-D-serine- (mas3) chelating moieties were evaluated in parallel, and a kit procedure for routine (99m)Tc-labeling was developed...
September 15, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27587032/technical-note-development-of-a-3d-printed-subresolution-sandwich-phantom-for-validation-of-brain-spect-analysis
#18
Ian S Negus, Robin B Holmes, Kirsty C Jordan, David A Nash, Gareth C Thorne, Margaret Saunders
PURPOSE: To make an adaptable, head shaped radionuclide phantom to simulate molecular imaging of the brain using clinical acquisition and reconstruction protocols. This will allow the characterization and correction of scanner characteristics, and improve the accuracy of clinical image analysis, including the application of databases of normal subjects. METHODS: A fused deposition modeling 3D printer was used to create a head shaped phantom made up of transaxial slabs, derived from a simulated MRI dataset...
September 2016: Medical Physics
https://www.readbyqxmd.com/read/27585576/spect-myocardial-blood-flow-quantitation-toward-clinical-use-a-comparative-study-with-13-n-ammonia-pet-myocardial-blood-flow-quantitation
#19
Bailing Hsu, Lien-Hsin Hu, Bang-Hung Yang, Lung-Ching Chen, Yen-Kung Chen, Chien-Hsin Ting, Guang-Uei Hung, Wen-Sheng Huang, Tao-Cheng Wu
OBJECTIVES: The aim of this study was to evaluate the accuracy of myocardial blood flow (MBF) quantitation of (99m)Tc-Sestamibi (MIBI) single photon emission computed tomography (SPECT) compared with (13)N-Ammonia (NH3) position emission tomography (PET) on the same cohorts. BACKGROUND: Recent advances of SPECT technologies have been applied to develop MBF quantitation as a promising tool to diagnose coronary artery disease (CAD) for areas where PET MBF quantitation is not available...
September 1, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27565154/recurrent-bladder-carcinoma-clinical-and-prognostic-role-of-18-f-fdg-pet-tc
#20
Pierpaolo Alongi, Federico Caobelli, Roberta Gentile, Alessandro Stefano, Giorgio Russo, Domenico Albano, Sergio Baldari, Maria Carla Gilardi, Massimo Midiri
AIM: A small number of studies evaluated the detection rate of lesions from bladder carcinoma (BC) of 18 F-FDG PET/CT in the restaging process. However, the prognostic role of FDG PET/CT still remains unclear. The aim of the present study was to evaluate the accuracy, the effect upon treatment decision, and the prognostic value of FDG PET/CT in patients with suspected recurrent BC. MATERIALS AND METHODS: Forty-one patients affected by BC underwent FDG PET/CT for restaging purpose...
August 26, 2016: European Journal of Nuclear Medicine and Molecular Imaging
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