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https://www.readbyqxmd.com/read/28323232/suspected-giant-cell-aortitis-from-multiple-aortic-structural-damage-to-fatal-listeria-sepsi-a-case-report
#1
Valeria Silvestri, Giacomo Isernia
Giant cell arteritis ( GCA) is an inflammatory vasculopathy affecting large and middle-sized vessels , specifically cranial arteries derived from carotid artery. Isolated extracranial vessel involvement can occur. Interest in extravascular manifestations is recently increasing because of diffusion of sensitive and specific imaging tools such as 18FDG PET TC . Patients have an increased relative risk of severe infection. Listeria monocytogenes infection risk is increased, and vascular system involvement and graft infection have been, even though rarely, reported...
March 16, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28319503/myocardial-infarction-in-a-patient-with-hypertrophic-cardiomyopathy-but-normal-coronary-arteries
#2
Shuheng Li, Xiaoxin Sun, Zongyao Zhang, Zuo-Xiang He
A 57-year-old man with a history of hypertrophic cardiomyopathy diagnosed by echocardiography experienced atypical chest pain and dyspnea for 6 months. A rest Tc-MIBI myocardial SPECT imaging and a F-FDG myocardial PET/CT imaging were performed, which showed multiple matched myocardial perfusion/metabolism defects in the left ventricle, indicating scar tissue. Surprisingly, subsequent contrast coronary angiography revealed no significant coronary artery stenosis.
March 17, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28319500/clinical-response-profile-of-metastatic-advanced-pulmonary-neuroendocrine-tumors-to-peptide-receptor-radionuclide-therapy-with-177lu-dotatate
#3
Rahul V Parghane, Sanjay Talole, Kumar Prabhash, Sandip Basu
OBJECTIVES: The aims of this study were to perform multiparametric response assessment of metastatic/advanced pulmonary neuroendocrine tumors (NETs) to Lu-DOTATATE peptide receptor radionuclide therapy (PRRT) (clinical, biochemical, molecular/structural imaging, and survival assessment) and to study the relationship between response, mortality, and overall survival with dual-tracer molecular imaging parameters. METHODS: Twenty-two patients (6 women, 16 men; median age, 44 years; range, 16-72 years) of histopathologically proven pulmonary NETs with metastatic/advanced disease were included and analyzed retrospectively...
March 17, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28315917/a-pediatric-hypophosphatemic-rickets-on-mri-99m-tc-mdp-bone-scan-and-18-f-fdg-pet-ct
#4
Changyun Xu, Chao Ma, Yongli Bai
We present a case of a 13 years old boy who was hospitalized with a 10 months history of progressive pain and weakness in his lower extremities. The laboratory tests revealed slightly decreased phosphate and 25-hydroxyvitamin D3, high alkaline phosphatase, normal calcium and parathyroid hormone (PTH). Magnetic resonance imaging (MRI) showed multiple patchy lesions indicating bone destruction in the metaphyses and epiphyses of the left knee. Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) revealed a generalized decrease of bone density in axial bones with slightly increased (18)F-FDG metabolism...
March 20, 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28291693/synthesis-and-evaluation-of-a-ligand-targeting-the-%C3%AE-and-%C3%AE-opioid-receptors-for-drug-delivery-to-lung-cancer
#5
Guo Li, Philip S Low
A well-established approach to developing new imaging agents and treatments for cancer begins with the recognition of receptors that are overexpressed in cancer cells. Ideally, these same receptors would also be absent, or minimally expressed, in healthy tissue. The mu (μ) and delta (δ) opioid receptors (MOR and DOR respectively) match these criteria, with expression in cancer cells that is higher than primary lung epithelial cells. Naltrexone is a drug approved by the U.S. Food and Drug Administration (FDA) for treatment of alcohol dependence or prevention of relapse from opioid addiction...
June 28, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28288383/effect-of-methoxy-group-position-on-biological-properties-of-18-f-labeled-benzyl-triphenylphosphonium-cations
#6
Shuting Chen, Zuoquan Zhao, Ying Zhang, Wei Fang, Jie Lu, Xianzhong Zhang
INTRODUCTION: (18)F-labeled phosphonium cations targeting mitochondrial membrane potential would be promising for positron emission tomography (PET) myocardial perfusion imaging (MPI). The purpose of this study was to examine the influence of additional methoxy group and its different positions on myocardium uptake and pharmacokinetics properties of (18)F-labeled benzyl triphenylphosphonium cations. METHOD: In this study, three novel (18)F-labeled phosphonium cations, [(18)F]4-(fluoromethyl)benzyltris(4-methoxyphenyl) phosphonium cation (1b), [(18)F]4-(fluoromethyl)benzyltris(2-methoxyphenyl) phosphonium cation (2b) and [(18)F]4-(fluoromethyl)benzyltris(3-methoxyphenyl) phosphonium cation (3b), were efficiently prepared by a One-Pot method starting from the substitution of non-carried-added fluoride-18...
February 24, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28244975/clinical-utility-of-99mtc-ubiquicidin-29-41-as-an-adjunct-to-bone-scan-in-differentiating-infected-versus-noninfected-loosening-of-prosthesis-before-revision-surgery
#7
Ajit S Shinto, Archana Mukherjee, Kamalaeshwaran Koramadai Karuppusamy, Jephy Joseph, Jyotsna Bhatt, Aruna Korde, Indira Upadhya, Chanda Arjun, Grace Samuel, Ashutosh Dash
PURPOSE: The aim of this study was to evaluate the utility of Tc-ubiquicidin (Tc-UBI) (29-41) as an adjunct to an methylene diphosphonate (MDP) bone scan in differentiating septic versus aseptic loosening in patients with painful prosthesis posted for revision surgery. PATIENTS AND METHODS: A two-vial cold kit of UBI (29-41) was prepared and utilized for the preparation of patient dose of Tc-UBI (29-41). Twenty two patients with painful hip or knee prosthesis and scheduled for revision surgery were included in the study...
April 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28242988/-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-scan-in-an-unusual-case-of-lymphoma-with-secondary-involvement-of-uterine-cervix-presenting-as-a-pathological-fracture
#8
Arun Sasikumar, Ajith Joy, M R A Pillai, Boben Thomas
A 48-year-old female presented with a pathological fracture of the right femur. (99m)Tc methylene diphosphonate bone scan revealed multiple areas of increased osteoblastic activity consistent with metastatic disease. Serum electrophoresis revealed monoclonal gammopathy. (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) scan revealed metabolically active lesions in bulky uterine cervix and osteolytic skeletal lesions. Unusual pattern of FDG uptake in uterine cervix and osteolytic skeletal lesions warranted a biopsy of the uterine cervix which revealed diffuse large B-cell lymphoma...
January 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28238581/correlation-of-technetium-99m-macroaggregated-albumin-and-yttrium-90-glass-microsphere-biodistribution-in-hepatocellular-carcinoma-a-retrospective-review-of-pretreatment-single-photon-emission-ct-and-posttreatment-positron-emission-tomography-ct
#9
Paul Haste, Mark Tann, Scott Persohn, Thomas LaRoche, Vasantha Aaron, Thibault Mauxion, Nikhil Chauhan, Matthew R Dreher, Matthew S Johnson
PURPOSE: To evaluate whether technetium-99 ((99m)Tc)-labeled macroaggregated albumin (MAA) can predict subsequent yttrium-90 ((90)Y) distribution and imaging response in patients with hepatocellular carcinoma (HCC). MATERIALS: Retrospective review was performed of records of 83 patients with HCC who underwent (90)Y glass microsphere radioembolization with (99m)Tc-MAA single photon emission computed tomography (SPECT) and (90)Y positron emission tomography (PET)/CT between January 2013 and December 2014...
February 23, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28218350/parathyroid-hyperplasia-detected-by-f-18-choline-pet-ct-negative-on-tc-99m-mibi-spect-ct-and-f-18-deoxyglucose-pet-ct-scans
#10
Anna Nocuń, Mariusz Kędra, Bogusław Stefaniak, Beta Chrapko
No abstract text is available yet for this article.
2017: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/28194631/development-of-a-new-folate-derived-ga-68-based-pet-imaging-agent
#11
Christian Brand, Valerie A Longo, Mike Groaning, Wolfgang A Weber, Thomas Reiner
PURPOSE: The folate receptor (FR) has emerged as an interesting diagnostic and therapeutic drug target with many potential applications in oncologic and inflammatory disorders. It was therefore the aim of this study to develop a folate-derived Ga-68-based positron emission tomography (PET) imaging tracer that is straightforward to radiolabel and could be broadly used in clinical studies. We validated its target binding affinity and specificity and compared it to [(99m)Tc]EC20, the folate single-photon emission computed tomography (SPECT) imaging tracer that has been most extensively studied clinically so far...
February 13, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28193503/clinical-translation-of-a-psma-inhibitor-for-99m-tc-based-spect
#12
Guillermina Ferro-Flores, Myrna Luna-Gutiérrez, Blanca Ocampo-García, Clara Santos-Cuevas, Erika Azorín-Vega, Nallely Jiménez-Mancilla, Emmanuel Orocio-Rodríguez, Jenny Davanzo, Francisco O García-Pérez
BACKGROUND: Prostate-specific membrane antigen (PSMA) is highly over-expressed in advanced prostate cancers. (68)Ga-labeled PSMA inhibitors (iPSMA) are currently used for prostate cancer detection by PET imaging. The availability of simple, efficient and reproducible radiolabeling procedures is essential for developing new SPECT radiopharmaceuticals for clinical translation. The aim of this research was to prepare (99m)Tc-EDDA/HYNIC-Lys(Nal)-Urea-Glu ((99m)Tc-EDDA/HYNIC-iPSMA) obtained from lyophilized kit formulations and evaluate the in vitro and in vivo radiopharmaceutical binding to prostate cancer cells over-expressing PSMA, as well as the (99m)Tc-EDDA/HYNIC-iPSMA normal biodistribution in humans and the preliminary uptake in patients with prostate cancer...
February 3, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28174106/radiosynthesis-and-evaluation-of-a-99m-tc-folic-acid-radiotracer-prepared-using-99m-tcn-pnp-2-metal-fragment
#13
Kusum Vats, Suresh Subramanian, Anupam Mathur, Haladhar Dev Sarma, Sharmila Banerjee
Folate receptors (FR) are over-expressed on a wide variety of tumor cells and are a potential molecular target for radiolabeled folates. In this respect, several SPECT and PET based radiofolates have been evaluated in the past albeit with their high renal uptake posing limitation towards their clinical use. To overcome this, a new (99m)Tc labeled folic acid was synthesized via the use of [(99m)TcN(PNP)](2+) metal fragment, where the presence of the latter pharmacophore redirects in vivo clearance via the hepatobiliary pathway...
March 30, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28166146/bone-scan-pet-ct-and-mri-in-disseminated-coccidioidomycosis
#14
John Randolph Dryden, Michael David Starsiak, Mickaila James Johnston, Eugene David Silverman
Coccidioidomycosis (valley fever) is a systemic fungal infection resulting from inhalation of the Coccidioides immitis or posadasii spores. In many cases, infection causes a self-limited community-acquired pneumonia; however, in patients with risk factors, such as immunosuppression or African or Pacific Island ancestry, significant morbidity and mortality from disseminated disease may occur. Presented here are comparative images using Tc-MDP bone scan, F-FDG PET/CT, and MRI. Each demonstrates particular strengths, which aid in assessing the extent of systemic involvement of a biopsy-proven case of disseminated coccidioidomycosis...
February 3, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28133240/-a-case-of-primary-peritoneal-cancer-successfully-treated-with-debulking-surgery-and-postoperative-chemotherapy
#15
Koki Maeda, Masami Tabata, Taiki Moriyama, Tatsuya Sakamoto, Yu Fujimura, Ichiro Ohsawa, Kenji Kato, Makoto Iwata, Takayuki Sanda
A 52-year-old woman with abdominal pain and a feeling of incomplete evacuation visited a local clinic. Enlargement of the right ovary was detected, and the patient was referred to the gynecological department of our hospital. CT and MRI revealed a round-shaped mass, 8 cm in diameter, with cystic and solid components in the Douglas pouch. The patient underwent a laparotomy under the diagnosis of ovarian cancer. Intraoperatively, both the ovaries appeared normal and the tumor strongly adhered to the rectum and uterus...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28123260/musculoskeletal-oncogenic-osteomalacia-an-experience-from-a-single-centre-in-south-india
#16
Anil Satyaraddi, Kripa Elizabeth Cherian, Sahana Shetty, Nitin Kapoor, Felix K Jebasingh, Vinoo Mathew Cherian, Julie Hephzibah, Anne Jennifer Prabhu, Nihal Thomas, Thomas V Paul
BACKGROUND: Oncogenic osteomalacia is an acquired form of hypophosphatemic osteomalacia where the tumour resection may lead to cure of the disease. Tumours originating from the musculoskeletal region form an important subgroup of oncogenic osteomalacia. METHODS: This was a retrospective study conducted at a tertiary care centre in south India where we analyzed the hospital records of all the patients with musculoskeletal oncogenic osteomalacia from January 2010-April 2016...
March 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/28123154/the-usefulness-of-positron-emission-tomography-findings-in-the-management-of-anterior-mediastinal-tumors
#17
Akihiko Kitami, Fumitoshi Sano, Shinichi Ohashi, Kosuke Suzuki, Shugo Uematsu, Takashi Suzuki, Mitsutaka Kadokura
PURPOSE: We performed a retrospective analysis to evaluate the usefulness of positron-emission tomography/computed tomography (PET/CT) findings in the classification and management of anterior mediastinal tumors. METHODS: Between 2006 and 2015, 105 patients with anterior mediastinal tumor received PET/CT. (18)F-fluorodeoxyglucose ((18)F-FDG)-PET images were obtained 60 minutes after the injection of (18)F-FDG. RESULTS: The histological classifications were as follows: thymoma (n = 49), thymic carcinoma (TC) (n = 19), malignant lymphoma (ML) (n = 8), teratoma (n = 7), thymic cyst (n = 14), and others (n = 8)...
February 20, 2017: Annals of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28121522/-18-f-fluorocholine-pet-mr-imaging-in-patients-with-primary-hyperparathyroidism-and-inconclusive-conventional-imaging-a-prospective-pilot-study
#18
Wouter P Kluijfhout, Jesse D Pasternak, Jessica E Gosnell, Wen T Shen, Quan-Yang Duh, Menno R Vriens, Bart de Keizer, Thomas A Hope, Christine M Glastonbury, Miguel H Pampaloni, Insoo Suh
Purpose To investigate the performance of flourine 18 ((18)F) fluorocholine (FCH) positron emission tomography (PET)/magnetic resonance (MR) imaging in patients with hyperparathyroidism and nonlocalized disease who have negative or inconclusive results at ultrasonography (US) and technetium 99m ((99m)Tc) sestamibi scintigraphy. Materials and Methods This study was approved by the institutional review board. Between May and December 2015, 10 patients (mean age, 70.4 years; range, 58-82 years) with biochemical primary hyperparathyroidism and inconclusive results at US and (99m)Tc sestamibi scintigraphy were prospectively enrolled...
January 25, 2017: Radiology
https://www.readbyqxmd.com/read/28120237/hibernating-substrate-of-ventricular-tachycardia-a-three-dimensional-metabolic-and-electro-anatomic-assessment
#19
Ayman A Hussein, Michelle Niekoop, Vasken Dilsizian, Yousra Ghzally, Mohammed Abdulghani, Ramazan Asoglu, Wengen Chen, Mark Smith, Vincent See, Stephen R Shorofsky, Timm-Michael Dickfeld
PURPOSE: Hibernating myocardium (HM) is associated with sudden cardiac death (SCD). Little is known about the electrophysiological properties of HM and the basis of its association with SCD. We aimed to electrophysiologically characterize HM in patients with ventricular tachycardia (VT). METHODS: Endocardial voltage mapping, metabolic (18)FDG-positron emission tomography (PET) and perfusion (82)Rb, (201)Tl, or (99m)Tc scans were performed in 61 ischemic heart disease patients with VT...
January 25, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28113072/rapid-synthesis-of-68-ga-labeled-macroaggregated-human-serum-albumin-maa-for-routine-application-in-perfusion-imaging-using-pet-ct
#20
D Mueller, Harshad Kulkarni, Richard P Baum, Andreas Odparlik
(99m)Tc-labeled MAA is commonly used for single photon emission computed tomography SPECT. In contrast, positron emission tomography/CT (PET/CT) delivers images with significantly higher resolution. The generator produced radionuclide (68)Ga is widely used for PET/CT imaging agents and (68)Ga-labeled MAA represents an attractive alternative to (99m)Tc-labeled MAA. We report a simple and rapid NaCl based labeling procedure for the labeling of MAA with (68)Ga using a commercially available MAA labeling kit for (99m)Tc...
January 9, 2017: Applied Radiation and Isotopes
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