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https://www.readbyqxmd.com/read/28050751/clinical-utility-of-18-f-fdg-positron-emission-tomography-computed-tomography-scan-vs-99m-tc-hmpao-white-blood-cell-single-photon-emission-computed-tomography-in-extra-cardiac-work-up-of-infective-endocarditis
#1
Trine K Lauridsen, Kasper K Iversen, Nikolaj Ihlemann, Philip Hasbak, Annika Loft, Anne K Berthelsen, Anders Dahl, Danijela Dejanovic, Elisabeth Albrecht-Beste, Jann Mortensen, Andreas Kjær, Henning Bundgaard, Niels Eske Bruun
The extra-cardiac work-up in infective endocarditis (IE) comprises a search for primary and secondary infective foci. Whether (18)FDG-PET/CT or WBC-SPECT/CT is superior in detection of clinically relevant extra-cardiac manifestations in IE is unexplored. The objectives of this study were to identify the numbers of positive findings detected by each imaging modality, to evaluate the clinical relevance of these findings and to define the reproducibility for extra-cardiac foci in patients with definite IE. Each modality was evaluated for numbers and location of positive extra-cardiac foci in patients with definite IE...
January 3, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28048559/we-ab-202-05-validation-of-lung-stress-maps-for-ct-ventilation-imaging
#2
G Cazoulat, J Kipritidis, S Siva, M Hofman, S Jolly, M Matuszak, J Balter, P Keall, K Brock
PURPOSE: To date, lung CT-ventilation imaging has been based on quantification of local breathing-induced changes in Hounsfield Units (HU) or volume. This work investigates the use of a stress map resulting from a biomechanical deformable image registration (DIR) algorithm as a metric of the ventilation function. METHOD: Eight lung cancer patients presenting different kinds of ventilation defects were retrospectively analyzed. Additionally, to the 4DCT acquired for radiotherapy planning, five of them had PET and three had SPECT imaging following inhalation of Ga-68 and Tc-99m, respectively...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048288/su-d-202-01-functional-lung-avoidance-and-response-adaptive-escalation-flare-rt-feasibility-of-a-precision-radiation-oncology-strategy
#3
S Bowen, E Lee, R Miyaoka, J Saini, P Kinahan, G Sandison, T Wong, H Vesselle, R Rengan, J Zeng
PURPOSE: NSCLC patient RT is planned without consideration of spatial heterogeneity in lung function or tumor response, which may have contributed to failed uniform dose escalation in a randomized trial. The feasibility of functional lung avoidance and response-adaptive escalation (FLARE) RT to reduce dose to [(9 9m) Tc]MAA-SPECT/CT perfused lung while redistributing 74Gy within [(1 8) F]FDG-PET/CT biological target volumes was assessed. METHODS: Eight Stage IIB-IIIB NSCLC patients underwent FDG-PET/CT and MAA-SPECT/CT treatment planning scans...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047036/we-fg-202-05-quantification-of-bone-flare-on-f-18-naf-pet-ct-in-metastatic-prostate-cancer
#4
A Weisman, S Harmon, T Perk, M Scarpelli, G Liu, R Jeraj
PURPOSE: Bone flare has been observed on Tc-99m bone scans during early assessment in metastatic Castration-Resistant Prostate Cancer (mCRPC) patients receiving select androgen-signaling pathway (AR) targeted treatments, including CYP17-inhibitor Abiraterone. This study investigates the appearance and potential clinical impact of bone flare in mCRPC patients receiving CYP17-inhibitors using (18) F-NaF PET/CT. METHODS: Twenty-three mCRPC patients being treated with CYP17-inhibitors received NaF PET/CT scans at baseline, week 6, and week 12 of treatment...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28033224/skeletal-scintigraphy-in-radiation-induced-fibrosis-with-lymphedema
#5
Jieqi Wang, Arya M Iranmanesh, M Elizabeth Oates
Despite increasing reliance on CT, MRI, and FDG PET/CT for oncological imaging, whole-body skeletal scintigraphy remains a frontline modality for staging and surveillance of osseous metastatic disease. We present a 54-year-old woman with metastatic breast cancer who received palliative external-beam radiation to the left ilium. Serial follow-up Tc-MDP bone scans demonstrated progressive soft-tissue uptake in her left lower extremity, extending from thigh to leg, with associated enlargement and skin thickening, consistent with lymphedema related to radiation-induced fibrosis...
December 28, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28033216/incremental-value-of-18f-fluorocholine-pet-ct-in-the-localization-of-double-parathyroid-adenomas
#6
Paul Lalire, Sang Ly, Sophie Deguelte, Martine Patey, David Morland
A 73-year-old man displaying primary hyperparathyroidism with severe hypercalcemia (Ca: 4.1 mmol/l, PTH > 600 pmol/l) was referred for preoperative localization of a parathyroid adenoma. Tc-pertechnetate and Tc-sestaMIBI dual tracer scintigraphy displayed a mild focal uptake in the projection of the right thyroid lobe with negative ultrasonography. F-Fluorocholine PET/CT was quickly performed considering this discrepancy and not only confirmed the scintigraphic findings but also revealed a second contralateral focus of increased uptake, both later confirmed by operative consideration (the two other parathyroid glands are considered normal by the surgeon), pathology, and intraoperative parathyroid hormone assessment...
December 28, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28007432/-188-re-image-performance-assessment-using-small-animal-multi-pinhole-spect-pet-ct-system
#7
Pedro L Esquinas, Cristina Rodríguez-Rodríguez, José Carlos De La Vega, Mehrdad Bokharaei, Katayoun Saatchi, Maryam Shirmohammad, Urs O Häfeli, Vesna Sossi, Anna Celler
PURPOSE: The goal of this study was to investigate the performance of a pre-clinical SPECT/PET/CT system for (188)Re imaging. METHODS: Phantom experiments were performed aiming to assess the characteristics of two multi-pinhole collimators: ultra-high resolution collimator (UHRC) and high-energy ultra high resolution collimator (HE-URHC) for imaging (188)Re. The spatial resolution, image contrast and contrast-to-noise ratio (CNR) were investigated using micro-Jaszczak phantoms...
December 19, 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/28004791/free-triiodothyronine-level-correlates-with-myocardial-injury-and-prognosis-in-idiopathic-dilated-cardiomyopathy-evidence-from-cardiac-mri-and-spect-pet-imaging
#8
Wenyao Wang, Haixia Guan, Wei Fang, Kuo Zhang, A Martin Gerdes, Giorgio Iervasi, Yi-Da Tang
Thyroid dysfunction is associated with poor prognosis in heart failure, but theories of mechanisms are mainly based on animal experiments, not on human level. We aimed to explore the relation between thyroid function and myocardial injuries in idiopathic dilated cardiomyopathy (IDCM) using cardiac magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT) and positron emission tomography (PET). Myocardial fibrosis was detected by late gadolinium enhancement (LGE) MRI, and myocardial perfusion/metabolism was evaluated by (99m)Tc-MIBI SPECT /(18)F-FDG PET imaging...
December 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28000164/respiratory-average-ct-for-attenuation-correction-in-myocardial-perfusion-spect-ct
#9
Duo Zhang, Bang-Hung Yang, Nien Yun Wu, Greta Seng Peng Mok
OBJECTIVE: Cine average CT (CACT) and interpolated average CT (IACT) have been proposed to improve attenuation correction (AC) for PET/CT in oncologic and cardiac studies. This study aims to evaluate their effectiveness on myocardial perfusion SPECT/CT using computer simulation and physical phantom experiments. METHODS: We first simulated normal male with (99m)Tc-sestamibi distribution using digital XCAT phantom with respiratory motion amplitudes of 2, 3, and 4 cm...
December 20, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27987028/left-ventricular-function-in-response-to-dipyridamole-stress-head-to-head-comparison-between-82-rubidium-pet-and-99m-tc-sestamibi-spect-ecg-gated-myocardial-perfusion-imaging
#10
Maria Clementina Giorgi, Jose Claudio Meneghetti, Jose Soares, Marisa Izaki, Andréa Falcão, Rodrigo Imada, William Chalela, Marco Antonio de Oliveira, Cesar Nomura, Hein J Verberne
PURPOSE: Myocardial perfusion imaging (MPI) with (99m)Tc-sestamibi (sestamibi) SPECT and rubidium-82 ((82)Rb) PET both allow for combined assessment of perfusion and left ventricular (LV) function. We sought to compare parameters of LV function obtained with both methods using a single dipyridamole stress dose. MATERIALS AND METHODS: A group of 221 consecutive patients (65.2 ± 10.4 years, 52.9% male) underwent consecutive sestamibi and (82)Rb MPI after a single dipyridamole stress dose...
December 16, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27941372/early-and-delayed-18f-fch-pet-ct-imaging-in-parathyroid-adenomas
#11
Cecilia Vellani, Marina Hodolič, Spyridon Chytiris, Giuseppe Trifirò, Domenico Rubello, Patrick M Colletti
Preoperative localization with Tc-sestaMIBI or ultrasound is a common prerequisite for successful minimally invasive parathyroid adenoma (PA) surgery. SPECT/CT with Tc-sestaMIBI and PET/CT with F-FCH offer the possibility of attenuation correction and coregistration of functional and anatomical images providing more accurate PA localization. F-FCH PET/CT is used predominantly in patients with prostate cancer and is under investigation in PA. We report the case of a 43-year-old man with early FCH uptake in a cystic PA with delayed washout at 60 minutes...
December 9, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27932119/oncological-evaluation-by-positron-emission-tomography-circulating-tumor-cells-and-alpha-fetoprotein-in-patients-with-hepatocellular-carcinoma-on-the-waiting-list-for-liver-transplantation
#12
P Ramirez, L Sáenz, P A Cascales-Campos, M R González Sánchez, E Llàcer-Millán, M I Sánchez-Lorencio, E Díaz-Rubio, V De La Orden, B Mediero-Valeros, J L Navarro, B Revilla Nuin, A Baroja-Mazo, J A Noguera-Velasco, B F Sánchez, J de la Peña, J A Pons-Miñano, F Sánchez-Bueno, R Robles-Campos, P Parrilla
INTRODUCTION: The objectives of this study are the determination of the number of circulating tumor cells (CTCs), by means of the IsoFlux enrichment system (Fluxion Biosciences Inc, San Francisco, California, United States) in patients with hepatocellular carcinoma (HCC) in compliance with the Milan criteria and on the waiting list for hepatic transplantation, as well as the study of its relation with the of α-fetoprotein levels (AFP) and positron-emission tomography-computed tomography (PET-CT) findings...
November 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27922334/ionizing-radiation-impairs-endogenous-regeneration-of-infarcted-heart-an-in-vivo-18-f-fdg-pet-ct-and-99m-tc-tetrofosmin-spect-ct-study-in-mice
#13
Lan Luo, Kodai Nishi, Yoshishige Urata, Chen Yan, Al Shaimaa Hasan, Shinji Goto, Takashi Kudo, Zhao-Lan Li, Tao-Sheng Li
Epidemiological studies have suggested that ionizing radiation increases cardiovascular disease risk, but the relevant mechanism is poorly understood. We recently demonstrated that adult mice exposed to whole-body irradiation with 3 Gy gamma rays significantly decreases the number and quality of cardiac stem cells. To further determine if radiation impairs myocardial regenerative potency, a myocardial infarction model was established in adult C57BL/6 mice by ligating the left anterior descending artery approximately 6 h after sham- or whole-body gamma irradiation (0 or 3 Gy)...
December 6, 2016: Radiation Research
https://www.readbyqxmd.com/read/27908147/strategies-for-ct-tissue-segmentation-for-monte-carlo-calculations-in-nuclear-medicine-dosimetry
#14
P E N Braad, T Andersen, S B Hansen, P F Høilund-Carlsen
PURPOSE: CT images are used for patient specific Monte Carlo treatment planning in radionuclide therapy. The authors investigated the impact of tissue classification, CT image segmentation, and CT errors on Monte Carlo calculated absorbed dose estimates in nuclear medicine. METHODS: CT errors as a function of patient size, CT reconstruction, and tube current modulation methods were assessed in a phantom experiment on a clinical CT system. The impact of tissue segmentation methods and CT number variations on EGSnrc Monte Carlo calculated absorbed dose distributions was assessed for (99m)Tc and (131)I in the ICRP/ICRU male phantom and in a patient PET/CT-scanned with (124)I prior to radioiodine therapy...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27890514/effectiveness-of-radiolabelled-somatostatin-analogues-90-y-dotatoc-and-177-lu-dotatate-in-patients-with-metastatic-neuroendocrine-tumours-a-single-centre-experience-in-mexico
#15
S S Medina-Ornelas, F O García-Pérez
OBJECTIVE: To determine the effectiveness of therapy with the radiolabelled somatostatin analogues, (90)Y-DOTATOC and (177)Lu-DOTATATE, in the treatment of metastatic neuroendocrine tumours with progression to first-line treatment. MATERIAL AND METHODS: A study was conducted on 30 patients diagnosed with neuroendocrine tumours (gastroenteropancreatic, bronchopulmonary, MEN2A, MEN2B, phaeochromocytoma, and paraganglioma) with metastatic disease diagnosed by the pathology department, with progression to first-line treatment, and recruited from December 2014 to February 2016...
November 24, 2016: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/27885455/-psma-radioguided-surgery-in-localized-recurrent-prostate-cancer-current-and-future-aspects
#16
I Rauscher, M Eiber, C A Jilg, J E Gschwend, T Maurer
Recently, PSMA-radioguided surgery (PSMA-RGS) was introduced for targeted resection of localized prostate cancer recurrence. Prerequisite for preoperative patient selection and localization of tumor recurrence is a positive (68)Ga-HBED-CC PSMA positron emission tomography (PET) scan with preferably only singular soft tissue or lymph node recurrence. After injection of In-PSMA I&T or Tc-PSMA-I&S single photon emission computer tomography (SPECT)/computer tomography (CT) examination is performed in every patient to verify radiotracer uptake in tumor lesions...
January 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/27879491/18f-fdg-pet-ct-in-renal-infections-evidence-of-acute-pyelonephritis-in-a-horseshoe-kidney
#17
Maxime Morelle, Alice Jaillard, Dimitri Bellevre, Guillaume Collet, Grégory Petyt
A 58-year-old paraplegic patient was prescribed F-FDG for persistent inflammatory syndrome after aortic surgery for dissection. The examination was performed on a Siemens mCT Flow PET/CT and shows a moderate prostate uptake, related to prostatitis on self-catheterization and a focal renal cortical hypermetabolism of the left medial midpole of a horseshoe kidney, which corresponds to renal parenchyma on the CT, and suggests pyelonephritis, confirmed by Tc-DMSA SPECT/CT.
November 22, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27879368/99mtc-duramycin-spect-imaging-of-early-tumor-response-to-targeted-therapy-a-comparison-with-18f-fdg-pet
#18
Filipe Elvas, Jan Boddaert, Christel Vangestel, Koon Pak, Brian Gray, Samir Kumar-Singh, Steven Staelens, Sigrid Stroobants, Leonie Wyffels
: Molecular imaging of cell death may provide a detailed readout of the cellular response to novel therapies and prognostic information on tumor treatment efficacy assisting in the design of individualized therapy. We compared the predictive power of cell death imaging using (99m)Tc-duramycin to current gold standard (18)F-FDG for treatment response evaluation after targeted therapy. METHODS: Early therapy response evaluation was assessed by (99m)Tc-duramycin SPECT and (18)F-FDG PET imaging in treatment-sensitive COLO205 and treatment-resistant HT29 human colorectal cancer xenografts 24 hours after a single dose of conatumumab or IgG1 control...
November 22, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27834016/is-c-11-methionine-pet-ct-able-to-localise-sestamibi-negative-parathyroid-adenomas
#19
Theresia Weber, Martin Gottstein, Sabrina Schwenzer, Ambros Beer, Markus Luster
BACKGROUND: Patients with primary hyperparathyroidism (pHPT) and a negative preoperative Tc-99 sestamibi (MIBI) scintigraphy are considered to have a higher risk of persistent disease. The aim of this study was to assess whether additional imaging with C-11 methionine positron emission tomography/computed tomography (Met-PET/CT) is able to localise sestamibi-negative hyperfunctioning parathyroid glands. METHODS: In 50 patients (38 females, 12 males, age 13-81 years) with pHPT and negative localisation procedures such as ultrasound and sestamibi, a Met-PET/CT was performed before parathyroid surgery...
November 10, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27825429/-18-f-naf-pet-ct-and-99m-tc-mdp-bone-scintigraphy-in-the-detection-of-bone-metastases-in-prostate-cancer
#20
REVIEW
Werner Langsteger, Alireza Rezaee, Christian Pirich, Mohsen Beheshti
(99m)Tc-MDP whole-body bone scintigraphy is a highly sensitive imaging method that has been used for decades to evaluate prostate cancer bone metastasis based on its availability and low cost; however, because of accumulation of this radiotracer in degenerative, traumatic, and inflammatory lesions, it suffers from noncomparable specificity. The modality is also used to monitor response to therapy and to predict patients' prognosis. As planar imaging may not give enough information for lesion detection or anatomical localization, it can be supplemented with SPECT to increase image contrast particularly in the evaluation of small and complex skeleton...
November 2016: Seminars in Nuclear Medicine
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