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Eosinophilic gastrointestinal disorder ( EGID )

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https://www.readbyqxmd.com/read/29127496/classification-of-eosinophilic-disorders-of-the-small-and-large-intestine
#1
Aoife J McCarthy, Kieran Sheahan
Eosinophilic gastrointestinal diseases (EGIDs), including eosinophilic gastroenteritis and eosinophilic colitis, have been increasing in prevalence in Western countries in recent years. Eosinophils are normally scanty in the gastrointestinal tract, and increased numbers of eosinophils can denote pathology. Normal values for tissue eosinophils vary widely between different segments of the colon, thus location of the biopsy is critically important for the interpretation of findings. However, no standard diagnostic criteria have been proposed for the diagnosis of eosinophilic gastroenteritis or eosinophilic colitis...
November 10, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29026737/eosinophilic-gastrointestinal-disorder-presenting-as-intractable-vomiting-and-ascites-in-a-young-girl
#2
Ji Yoon Kwon, Ji Sun Huh, Bo Kyung Je, Kwang Dae Hong, Jee Hyun Lee
Eosinophilic gastrointestinal disorder (EGID) is a rare disease in children that affects the bowel wall, with eosinophilic infiltration in the absence of any other causes for eosinophilia. The etiology remains unknown, but allergies and immunological imbalance are suspected triggers. We encountered a case of serosal EGID presenting as intractable vomiting and ascites in a 9-year-old girl, after influenza virus infection. Peripheral eosinophilia was not present. The diagnosis was confirmed by biopsy of the bowel wall through laparotomy and endoscopy, and controlled by 2 courses of steroid therapy due to recurring symptoms...
September 2017: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/28960628/treatment-of-gastric-eosinophilia-by-epicutaneous-immunotherapy-in-piglets-sensitized-to-peanuts
#3
L Mondoulet, N Kalach, V Dhelft, T Larcher, C Delayre-Orthez, P H Benhamou, J Spergel, H A Sampson, C Dupont
BACKGROUND: Eosinophilic Gastrointestinal Disorders (EGIDs) are hypersensitivity disorders frequently triggered by food allergy and manifested by mucosal eosinophilic infiltration at any level of the gastro-intestinal tract. This study established a model of gastric eosinophilia in peanut-sensitized piglets to evaluate the efficacy of epicutaneous immunotherapy (EPIT) for its treatment. METHODS: Experiments were carried out in piglets first sensitized by 3 intra-peritoneal injections of peanut protein extract (PPE) with adjuvant, and then given PPE orally for 10 days, a sequence leading to gastric eosinophilia assessed by endoscopy...
September 28, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28607327/m%C3%A3-n%C3%A3-trier-s-disease-as-a-gastrointestinal-manifestation-of-active-cytomegalovirus-infection-in-a-22-month-old-boy-a-case-report-with-a-review-of-the-literature-of-korean-pediatric-cases
#4
Jeana Hong, Seungkoo Lee, Yoonjung Shon
Ménétrier's disease (MD), which is characterized by hypertrophic gastric folds and foveolar cell hyperplasia, is the most common gastrointestinal (GI) cause of protein-losing enteropathy (PLE). The clinical course of MD in childhood differs from that in adults and has often been reported to be associated with cytomegalovirus (CMV) infection. We present a case of a previously healthy 22-month-old boy presenting with PLE, who was initially suspected to have an eosinophilic GI disorder (EGID). However, he was eventually confirmed, by detection of CMV DNA using polymerase chain reaction (PCR) with gastric tissue, to have MD associated with an active CMV infection...
June 13, 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/28603057/prevalence-of-eosinophilic-gastroenteritis-and-colitis-in-a-population-based-study-from-2012-to-2017
#5
Emad Mansoor, Mohannad Abou Saleh, Gregory S Cooper
BACKGROUND & AIMS: Although eosinophilic esophagitis (EoE) has been extensively studied, there have been few epidemiology studies of other eosinophilic gastrointestinal disorders (EGIDs). Using a large, population-based database, we investigated epidemiologic features of eosinophilic gastroenteritis (EoGE) and eosinophilic colitis (EoC) in the United State. METHODS: We collected data from a commercial database (Explorys Inc, Cleveland, OH) that provided electronic health records from 26 major integrated U...
November 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28370248/the-pathology-and-causes-of-tissue-eosinophilia-in-the-gastrointestinal-tract
#6
REVIEW
James R Conner, Richard Kirsch
Eosinophilic inflammation in the gastrointestinal tract may occur as a primary eosinophilic disorder or as a secondary response with other causes. Primary eosinophilic gastrointestinal disorders (EGIDs) are Th2-mediated allergic diseases that overlap pathogenetically with atopic conditions involving other organs. The pathological diagnosis of primary EGIDs can be challenging, as the quantity of eosinophils considered to be 'abnormal' is difficult to define, and the diagnosis, by definition, requires exclusion of the far more common secondary causes...
August 2017: Histopathology
https://www.readbyqxmd.com/read/27382945/eosinophilic-gastroenteritis%C3%A2-brief-review
#7
REVIEW
H-M Shih, M-J Bair, H-L Chen, I-T Lin
Eosinophilic gastroenteritis (EGE) is a rare disease which belongs to primary eosinophilic gastrointestinal disorders (primary EGIDs), characterized by an accumulation of eosinophils in the gastrointestinal (GI) tract and is strongly associated with atopy and allergy. The clinical presentations vary depending on the site and depth of eosinophilic intestinal infiltration. Radiology pictures may show irregular thickening of the folds, but these findings can also be present in other conditions like inflammatory bowel disease and lymphoma...
April 2016: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/27191032/pharmacological-treatment-of-eosinophilic-gastrointestinal-disorders
#8
REVIEW
Susan Hua, Dane Cook, Marjorie M Walker, Nicholas J Talley
INTRODUCTION: Eosinophilic gastrointestinal disorders (EGIDs) are increasingly prevalent chronic inflammatory diseases characterized by eosinophilic infiltration of the gastrointestinal (GI) tract, in the absence of other known causes of eosinophilia. AREAS COVERED: Clinical management of EGIDs is challenging, as there are currently limited therapeutic options available. The most common EGID is eosinophilic esophagitis (EoE), and rarer forms are eosinophilic gastritis, eosinophilic gastroenteritis, and eosinophilic colitis...
September 2016: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/26840762/eosinophilic-gastroenteritis-in-a-patient-with-bruton-s-tyrosine-kinase-deficiency
#9
Susumu Yamazaki, Yoshikazu Ohtsuka, Tomoaki Yokokura, Rena Yokota, Asuka Honjo, Eisuke Inage, Yosuke Baba, Mari Mori, Ryuyo Suzuki, Tsutomu Iwata, Toshiaki Shimizu
Eosinophilic gastrointestinal diseases (EGID) are relatively rare diseases characterized by eosinophilic infiltration of the gastrointestinal tract resulting in various gastrointestinal symptoms. EGID are often caused by allergic reactions or systemic eosinophilic disorders, but their comorbidity with Bruton's tyrosine kinase (BTK) deficiency has not been previously documented. Here, we report a case of eosinophilic gastroenteritis (EG) in a patient with BTK deficiency. Despite adequate replacement immunoglobulin (Ig) therapy, trough serum IgG was not maintained...
February 3, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/26709253/eosinophilic-gastrointestinal-disorders-associated-with-autoimmune-connective-tissue-disease
#10
Marie Lecouffe-Desprets, Matthieu Groh, Bruno Bour, Claire Le Jeunne, Xavier Puéchal
OBJECTIVES: To determine the clinical and pathological characteristics of eosinophilic gastrointestinal disease (EGID) associated with autoimmune connective tissue disease (CTD). METHODS: Systematic literature review. RESULTS: Twenty cases of CTD associated with EGID were identified. Systemic lupus erythematosus was the main EGID-associated CTD (35%), followed by rheumatoid arthritis (20%), systemic sclerosis or inflammatory myopathies (15%, each), and Sjögren's syndrome, scleromyositis or other overlapping connective tissue disease (5%, each)...
October 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/26117257/racial-differences-in-eosinophilic-gastrointestinal-disorders-among-caucasian-and-asian
#11
REVIEW
Jun Ito, Takeo Fujiwara, Reiji Kojima, Ichiro Nomura
BACKGROUND: Although there is an increasing number of eosinophilic gastrointestinal disorders (EGID) cases including eosinophilic esophagitis (EoE) and eosinophilic gastroenteritis (EGE), being reported globally, no systematic reviews have been conducted to elucidate the racial differences in these disorders. We aimed to show the racial differences, especially among Caucasians and Asians, in the risk of EoE and EGE. METHODS: We conducted a systematic review using PubMed in September 2012...
July 2015: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/25988554/prevalence-of-eosinophilic-gastritis-gastroenteritis-and-colitis-estimates-from-a-national-administrative-database
#12
Elizabeth T Jensen, Christopher F Martin, Michael D Kappelman, Evan S Dellon
OBJECTIVES: Eosinophilic esophagitis (EoE) is becoming increasingly more common, but the prevalence of other eosinophilic gastrointestinal disorders (EGIDs) is unknown. Our objective was to estimate the prevalence of eosinophilic gastritis, gastroenteritis, and colitis in the United States. METHODS: We used the IMS Health LifeLink PharMetrics Plus Claims Database, data representative of a US national commercially insured population containing medical and pharmaceutical claims for > 75 million individuals...
January 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/25925921/eosinophilic-enteritis
#13
REVIEW
Guillaume Pineton de Chambrun, Pierre Desreumaux, Antoine Cortot
BACKGROUND: Eosinophilic enteritis, also known as eosinophilic gastroenteritis, is a rare primary eosinophilic gastrointestinal disorder (EGID) of unknown etiology characterized by the presence of an intense eosinophilic infiltrate on histopathology of the intestinal mucosa. KEY MESSAGES: The etiology of eosinophilic enteritis remains obscure. There is growing evidence to support the role of aeroallergens and food allergens in the pathogenesis of this disorder as children and adults with EGIDs often have positive skin testing for food allergens and a familial history of allergic diseases...
2015: Digestive Diseases
https://www.readbyqxmd.com/read/25866707/significance-of-mouse-models-in-dissecting-the-mechanism-of-human-eosinophilic-gastrointestinal-diseases-egid
#14
Anil Mishra
Evidence suggests that eosinophils play a significant role in promoting several gastrointestinal diseases, and animal models are the significant tools to understand the pathogenesis of eosinophil-associatd inflammatory disorders. The focus of this review is on the significance of mouse models that mimic the characteristics of human eosinophilic gastrointestinal diseases. Eosinophils are the important leukocytes with diverse functions in the gastrointestinal tract, such as excretion of intestinal parasites and promoting the pathogenesis of a numerous allergic gastrointestinal disorders like food allergy, parasitic infection, allergic gastroenteritis, allergic colitis, and eosinophilic esophagitis...
2013: Journal of Gastroenterology and Hepatology Research
https://www.readbyqxmd.com/read/25358014/eosinophilic-gastrointestinal-disease-and-inflammatory-bowel-disease-in-children-is-it-a-disease-continuum
#15
Mohamed Mutalib, Sarah Blackstock, Victoria Evans, Bonita Huggett, Sibongile Chadokufa, Fevronia Kiparissi, Mamoun Elawad
Eosinophilic gastrointestinal disease (EGID) and inflammatory bowel disease (IBD) are two distinct disorders that share some clinical manifestations but have different diagnostic criteria. In this article, we reviewed the clinical data of three children with EGID who later developed IBD. This study is a retrospective case note review that was conducted between 2007 and 2012. EGID seems to precede IBD in some subsets of children in whom the diagnosis of IBD may take a few years to fully develop.
January 2015: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/24345843/increased-prevalence-of-eosinophilic-gastrointestinal-disorders-in-pediatric-pten-hamartoma-tumor-syndromes
#16
Carol J Henderson, Joanne Ngeow, Margaret H Collins, Lisa J Martin, Philip E Putnam, Juan P Abonia, Keith Marsolo, Charis Eng, Marc E Rothenberg
OBJECTIVES: The PTEN hamartoma tumor syndromes (PHTSs) are a collection of disorders caused by germline mutations of the tumor suppressor gene PTEN. Eosinophilic gastrointestinal disorders (EGIDs) are rare diseases characterized by food-induced, eosinophil-dominant inflammation in various segments of the gastrointestinal tract. On the basis of our clinical observations of several patients with EGID-PHTS, we investigated whether there is an association between these 2 disorders. METHODS: The Cincinnati Children's Hospital Medical Center (CCHMC) Informatics for Integrating Biology and the Bedside (i2b2) warehouse was queried for the years 2007 to 2012 using International Classification of Diseases-9 codes for PTEN-related diseases; the results were cross-referenced with participants enrolled in the Cincinnati Center for Eosinophilic Disorder's EGID database to identify patients with both disorders...
May 2014: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/24157935/disease-specific-self-efficacy-in-the-eosinophilic-gastrointestinal-disorders
#17
Sarah Ballou, Tiffany Taft, Laurie Keefer
Eosinophilic gastrointestinal disorders (EGIDs) are chronic inflammatory conditions with increasing global prevalence. Self-efficacy is important for patients' ability to manage chronic disease. We sought to evaluate disease-specific self-efficacy in the EGIDs via a modified version of the Inflammatory Bowel Disease Self-Efficacy Scale (IBD-SES). Ninety-one Participants reported demographic, clinical, and psychosocial variables. The IBD-SES demonstrated excellent reliability and validity in this population...
August 2015: Journal of Health Psychology
https://www.readbyqxmd.com/read/23974876/gastrointestinal-food-allergy-in-infants
#18
Hideaki Morita, Ichiro Nomura, Akio Matsuda, Hirohisa Saito, Kenji Matsumoto
Food allergies are classified into three types, "IgE-mediated," "combined IgE- and cell-mediated" and "cell-mediated/non-IgE-mediated," depending on the involvement of IgE in their pathogenesis. Patients who develop predominantly cutaneous and/or respiratory symptoms belong to the IgE-mediated food allergy type. On the other hand, patients with gastrointestinal food allergy (GI allergy) usually develop gastrointestinal symptoms several hours after ingestion of offending foods; they belong to the cell-mediated/non-IgE-mediated or combined IgE- and cell-mediated food allergy types...
September 2013: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/23874072/case-control-study-of-association-of-eosinophilic-gastrointestinal-disorders-with-helicobacter-pylori-infection-in-japan
#19
Kenji Furuta, Kyoichi Adachi, Masahito Aimi, Norihisa Ishimura, Shuichi Sato, Shunji Ishihara, Yoshikazu Kinoshita
Recent studies have suggested that decrease in Helicobacter pylori infection may predispose to allergic diseases. However, there are few reports of the relationships of eosinophilic gastrointestinal disorders (EGIDs), especially eosinophilic gastroenteritis (EGE), with H. pylori infection. We investigated the possible influence of H. pylori infection on EGIDs in Japanese patients. We performed a case-control study to investigate the prevalence of H. pylori infection in patients with EGIDs. Eighteen with eosinophilic esophagitis (EoE) and 22 with EGE were enrolled...
July 2013: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/22882380/behavioral-feeding-problems-and-parenting-stress-in-eosinophilic-gastrointestinal-disorders-in-children
#20
Yelena P Wu, James P Franciosi, Marc E Rothenberg, Kevin A Hommel
BACKGROUND: Children with eosinophilic gastrointestinal disorders (EGID) and their families are asked to adhere to dietary restrictions which can present significant daily challenges. However, little is known about child and family functioning and adaptation and the impact of psychosocial functioning (e.g., behavioral feeding problems) on adherence to dietary restrictions in this pediatric population. METHODS: We conducted a gender- and age-matched case-control study wherein parents of children with EGID and healthy control children completed measures of behavioral feeding problems, parenting stress, and adherence to prescribed dietary restrictions...
December 2012: Pediatric Allergy and Immunology
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