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Eosinophilic esophagitis (EOE)

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https://www.readbyqxmd.com/read/29435312/determinant-factors-of-quality-of-life-in-adult-patients-with-eosinophilic-esophagitis
#1
Alfredo J Lucendo, Laura Arias-González, Javier Molina-Infante, Ángel Arias
Background: Eosinophilic esophagitis (EoE) affects health-related quality of life (HRQoL). Data on determinant factors and the influence of dietary interventions are scarce. Objective: The objective of this article is to evaluate factors influencing HRQoL in adult EoE patients. Methods: We conducted a multicenter observational, cross-sectional study. A validated Spanish version of the self-administered Adult Eosinophilic Esophagitis Quality of Life (EoE-QoL-A) questionnaire and specific surveys were used...
February 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29435311/rising-incidence-and-prevalence-of-adult-eosinophilic-esophagitis-in-midwestern-spain-2007-2016
#2
Javier Molina-Infante, Pedro Luis Gonzalez-Cordero, Hal Cliff Ferreira-Nossa, Pilar Mata-Romero, Alfredo J Lucendo, Angel Arias
Objectives: Epidemiologic studies on eosinophilic esophagitis (EoE) are scarce and patient responders to proton pump inhibitor (PPI) therapy have usually been excluded. We aimed to evaluate population-based incidence rates, prevalence and trends in adult EoE over the past decade, including responders to PPI therapy. Methods: We conducted an analysis of a prospectively established case registry in the health area of Cáceres, located in midwestern Spain. From the first EoE case diagnosed in 2007, endoscopy and pathology reports up to December 2016 were manually reviewed...
February 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29427131/eosinophilic-esophagitis-through-the-flexible-endoscope-and-the-lens-of-a-photographer-in-the-amazon
#3
REVIEW
Amal Assa'ad
Eosinophilic esophagitis (EoE) is a disorder that has been identified recently, thus knowledge about it, its pathogenesis, and potential etiologies has spread in an era where the medical community and the public are receiving the information and discussing it as it appears in the medical literature. Because physiology, pathology, and pathophysiology are difficult to explain in layman terms, the author has used photographs taken in remote areas of the Amazon to create visual similes within a narrative that brings the scientific and medical concepts of the knowledge on EoE to a level that allows both medical and non-medical persons to grasp and discuss their significance...
February 9, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29424023/integrin-%C3%AE-m-activation-and-upregulation-on-esophageal-eosinophils-and-periostin-mediated-eosinophil-survival-in-eosinophilic-esophagitis
#4
Praveen Vimalathas, Alexandra Farris, Dorothea Letner, Vikram Deshpande, Vijay Yajnik, Wayne Shreffler, John Garber
Eosinophilic esophagitis (EoE) is increasingly recognized allergic disease associated with dysphagia and esophageal fibrosis. We aimed to determine expression patterns of specific eosinophil integrins that promote eosinophilic infiltration of the esophageal epithelium, and to determine how key EoE-related cytokines influence eosinophil activation and survival. Esophageal and peripheral eosinophils were isolated from 20 adult subjects with EoE for immunophenotyping and integrin profiling using multicolor flow cytometry and immunohistochemistry...
February 9, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29422678/clinical-translation-of-tethered-confocal-microscopy-capsule-for-unsedated-diagnosis-of-eosinophilic-esophagitis
#5
Nima Tabatabaei, DongKyun Kang, Minkyu Kim, Tao Wu, Catriona N Grant, Mireille Rosenberg, Norman S Nishioka, Paul E Hesterberg, John Garber, Qian Yuan, Aubrey J Katz, Guillermo J Tearney
Esophagogastroduodenoscopy (EGD) is a widely used procedure, posing significant financial burden on both healthcare systems and patients. Moreover, EGD is time consuming, sometimes difficult to tolerate, and suffers from an imperfect diagnostic yield as the limited number of collected biopsies does not represent the whole organ. In this paper, we report on technological and clinical feasibility of a swallowable tethered endomicroscopy capsule, which is administered without sedation, to image large regions of esophageal and gastric mucosa at the cellular level...
February 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29399613/ankylosaurus-back-sign-novel-endoscopic-finding-in-esophageal-eosinophilia-patients-indicating-proton-pump-inhibitor-response
#6
Norihisa Ishimura, Shohei Sumi, Mayumi Okada, Daisuke Izumi, Hironobu Mikami, Eiko Okimoto, Nahoko Ishikawa, Yuji Tamagawa, Tsuyoshi Mishiro, Naoki Oshima, Kotaro Shibagaki, Shunji Ishihara, Riruke Maruyama, Yoshikazu Kinoshita
Background and study aims : Characteristic endoscopic findings, such as linear furrows, rings, and whitish exudates, indicate the presence of esophageal eosinophilia (EE), though no specific findings are known to distinguish eosinophilic esophagitis (EoE) from proton pump inhibitor-responsive esophageal eosinophilia (PPI-REE). Here, we present a novel endoscopic finding in some EE patients possessing a linear longitudinal arrangement of whitish nodules with the appearance of the back of an Ankylosaurus dinosaur, termed Ankylosaurus back sign (ABS), and evaluations of its significance in affected patients...
February 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29394215/practice-differences-in-the-diagnosis-and-management-of-eosinophilic-esophagitis-among-adult-and-pediatric-gastroenterologists-in-israel
#7
Eyal Zifman, Hagar Banai, Raanan Shamir, Tamar Ringel-Kulka, Noam Zevit
OBJECTIVES: Eosinophilic esophagitis (EoE) guidelines call for similar practices in adults and children with EoE. We compared the diagnostic and management practices of gastroenterologists treating adult and pediatric patients suspected of having, or diagnosed with, EoE. METHODS: A 19 question multiple choice questionnaire was given to gastroenterologists treating either adults or children. Questions explored four areas of interest: Physician demographics, diagnosis and tissue sampling practices, management, and the need for societal publications on EoE...
February 1, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29381255/airborne-and-food-sensitization-patterns-in-children-and-adults-with-eosinophilic-esophagitis
#8
Yu Ting He, Paul J Christos, William R Reisacher
BACKGROUND: The pathogenesis of eosinophilic esophagitis (EoE) is currently unknown, but evidence suggests that allergic sensitization to food and airborne allergens may play a key role. This retrospective study examines the rate of sensitization to both food and airborne allergens in EoE patients, and compares their sensitivity patterns to control groups. METHODS: We identified 103 patients with a diagnosis of EoE via esophageal eosinophilia (≥15 eosinophils/high-power field [hpf]), who had undergone comprehensive food and/or airborne allergen testing through either skin or in vitro methods...
January 30, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29380175/combined-and-alternating-topical-steroids-and-food-elimination-diet-for-the-treatment-of-eosinophilic-esophagitis
#9
Craig C Reed, Anca M Safta, Shadi Qasem, M Angie Almond, Evan S Dellon, Elizabeth T Jensen
BACKGROUND: Few studies have examined combined or alternating treatment algorithms in eosinophilic esophagitis. AIMS: We conducted a retrospective cohort study to ascertain the efficacy and adherence to a combined and alternating treatment approach with topical corticosteroids and 2-food elimination diet for pediatric EoE. METHODS: Patients were prescribed a 2-food elimination diet (milk and soy) and topical corticosteroid (fluticasone or oral viscous budesonide) for 3 months, after which the steroid was discontinued and 2-food elimination diet continued for 3 months...
January 29, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29377264/understanding-fibrosis-in-eosinophilic-esophagitis-are-we-there-yet
#10
REVIEW
Jennifer Armbruster-Lee, Cary P Cavender, Jay A Lieberman, Amali E Samarasinghe
Eosinophilic esophagitis (EoE) is an immune/antigen-mediated, progressive fibrostenotic disease characterized by symptoms of esophageal dysfunction and abnormal eosinophilic infiltration in the esophagus. Despite current treatment modalities of dietary antigen elimination or topical corticosteroids, a subset of patients do not have clinical or histologic response. Even with resolution of superficial epithelial eosinophilia, patients may still have progressive subepithelial fibrosis, which may lead to esophageal strictures over time...
January 29, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29372536/biological-therapies-for-eosinophilic-esophagitis-where-do-we-stand
#11
REVIEW
Emily Ko, Mirna Chehade
Eosinophilic esophagitis (EoE) is an immune-mediated, chronic esophageal disease characterized by esophageal symptoms and esophageal eosinophilia. It is triggered by foods and possibly by environmental allergens. Currently, there are no FDA-approved therapies for EoE. Commonly used treatments include dietary restrictions and topical corticosteroids. Many of these therapies are suboptimal in their efficacy, have side effects, or diminish patients' quality of life. Biologic therapies for EoE have therefore been sought as an alternative...
January 25, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29357016/new-developments-in-the-diagnosis-therapy-and-monitoring-of-eosinophilic-esophagitis
#12
REVIEW
Ronak Vashi Patel, Ikuo Hirano
PURPOSE OF REVIEW: Eosinophilic esophagitis (EoE) has transformed over the past two decades from a little-known entity to a significant cause of morbidity in the adult and pediatric population. We reviewed the most recent advancements in the diagnosis, therapy, and long-term monitoring of EoE. RECENT FINDINGS: Based on clinical, endoscopic, histologic, immunologic, and genetic similarities, there is growing consensus to move away from distinguishing proton pump inhibitor responsive esophageal eosinophilia as an entity distinct from EoE...
January 22, 2018: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/29356936/does-aeroallergen-sensitization-cause-or-contribute-to-eosinophilic-esophagitis
#13
REVIEW
Jesus R Guajardo, Melissa A Zegarra-Bustamante, Edward G Brooks
Eosinophilic esophagitis is an atopic disease defined clinically by esophageal symptoms in combination with a dense esophageal eosinophilia. EoE is triggered and maintained by exposure to certain foods and it is known that dietary modification controls symptoms and achieves disease remission. Recently, aeroallergens have been implicated in the pathogenesis of EoE. To examine the role of aeroallergens in EoE, we reviewed the published literature. Sensitization and production of IgE antibodies to foods and aeroallergens in subjects with EoE has been demonstrated...
January 22, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29350339/emerging-insights-into-the-esophageal-microbiome
#14
REVIEW
Michael May, Julian A Abrams
PURPOSE OF REVIEW: Analysis of the esophageal microbiome remains a relatively new field of research, and most studies to date have focused on characterizing the esophageal microbiome in states of health and disease. Microbiome alterations have been implicated in the pathogenesis of inflammatory and neoplastic conditions in the colon and elsewhere in the gastrointestinal tract. The epidemiology of various esophageal conditions including Barrett's esophagus (BE), esophageal adenocarcinoma (EAC), esophageal squamous cell carcinoma (ESCC), and eosinophilic esophagitis (EoE) point to the microbiome as a potential co-factor in disease pathogenesis, and the possibility exists that these microbiome alterations could contribute directly to the inflammatory environments necessary for the carcinogenesis or atopy involved in these conditions...
January 19, 2018: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/29349695/efficacy-of-atopy-patch-testing-in-directed-dietary-therapy-of-eosinophilic-esophagitis-a-pilot-study
#15
Jason D Eckmann, Karthik Ravi, David A Katzka, Dawn R Davis, Jacalyn A See, Debra R Geno, Lori A Kryzer, Jeffrey A Alexander
BACKGROUND: Atopy patch testing (APT) has shown potential for predicting dietary food triggers in studies of children and adolescents with eosinophilic esophagitis (EoE). AIMS: To assess the efficacy of APT in adults with EoE. METHODS: We conducted a prospective open-label pilot study of patients ≥ 18 years old with diagnosis of EoE at Mayo Clinic in Rochester, Minnesota, from November 2014 to January 2016. All patients underwent patch testing using intact food products, followed by a six food elimination diet and stepwise food reintroduction...
January 18, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29348584/quail-egg-homogenate-alleviates-food-allergy-induced-eosinophilic-esophagitis-like-disease-through-modulating-par-2-transduction-pathway-in-peanut-sensitized-mice
#16
Priscilia Lianto, Shiwen Han, Xinrui Li, Fredrick Onyango Ogutu, Yani Zhang, Zhuoyan Fan, Huilian Che
The present pharmacotherapy for eosinophilic esophagitis (EoE) fundamentally depend on inhaled corticosteroids. Despite the fact that oral intake of topical steroids can be successful in restricting EoE-related inflammation, there are concerns with respect to the long term utilization of steroids, especially in kids. In the current research, we assess the effect of quail egg, which is reportedly a known serine protease inhibitor, on symptomatology and immune responses in a peanut-sensitized mouse model of food allergy induced EoE...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29338961/is-eosinophilic-esophagitis-an-equivalent-of-pollen-allergic-asthma-analysis-of-biopsies-and-therapy-guided-by-component-resolved-diagnosis
#17
A Armentia, S Martín-Armentia, B Martín-Armentia, J Santos-Fernández, R Álvarez, B Madrigal, D Fernández-González, S Gayoso, M J Gayoso
BACKGROUND: Eosinophilic esophagitis (EoE) is characterized by esophageal dysfunction and, histologically, by eosinophilic inflammation. There is not a clear etiologic treatment. Biopsies analysis using plant histology methods may show callose and pollen tubes in the esophageal mucosa. Component-resolved diagnosis (CRD) with microarrays could detect possible allergens involved and indicate an elimination diet and allergen immunotherapy (AIT). METHODS: One hundred and twenty-nine patients with EoE were tested for environmental and food allergens...
January 12, 2018: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29336433/eosinophilic-esophagitis-relationship-of-subepithelial-eosinophilic-inflammation-with-epithelial-histology-endoscopy-blood-eosinophils-and-symptoms
#18
Alain M Schoepfer, Audrey Simko, Christian Bussmann, Ekaterina Safroneeva, Marcel Zwahlen, Thomas Greuter, Luc Biedermann, Stephan Vavricka, Sébastien Godat, Antoine Reinhard, Catherine Saner, Hugo Maye, Christine Sempoux, Christophe Brunel, Carine Blanchard, Dagmar Simon, Hans-Uwe Simon, Alex Straumann
OBJECTIVES: For technical reasons, the histologic characterization of eosinophilic esophagitis (EoE)-specific alterations is almost exclusively based on those found in the esophageal epithelium, whereas little is known about subepithelial abnormalities. In this study, we aimed to systematically assess the nature of subepithelial histologic alterations, and analyze their relationship with epithelial histologic findings, endoscopic features, and symptoms. METHODS: Adult patients with established EoE diagnosis were prospectively included during a yearly follow-up visit...
January 16, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29332138/pathophysiology-of-eosinophilic-esophagitis
#19
REVIEW
Benjamin P Davis
Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the esophagus associated with an atopic predisposition which appears to be increasing in prevalence over the last few decades. Symptoms stem from fibrosis, swelling, and smooth muscle dysfunction. In the past two decades, the etiology of EoE has been and is continuing to be revealed. This review provides an overview of the effects of genetics, environment, and immune function including discussions that touch on microbiome, the role of diet, food allergy, and aeroallergy...
January 13, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29290036/eosinophilic-esophagitis-clinical-manifestations-and-differential-diagnosis
#20
REVIEW
Diana Muñoz-Mendoza, Adrián Chapa-Rodríguez, Sami L Bahna
As a chronic inflammatory disease with eosinophilic infiltrate of the esophagus, eosinophilic esophagitis (EoE) causes a variety of gastrointestinal (GI) clinical manifestations. None of the symptoms, endoscopic features, or biopsy findings is pathognomonic of the disease, even with high degrees of esophageal eosinophilia. The pathogenesis has been explored by several studies, yet it still far from being completely understood. Evidence supports a role of allergen-driven Th2 lymphocyte mechanism, though not in every patient...
December 30, 2017: Clinical Reviews in Allergy & Immunology
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