keyword
https://read.qxmd.com/read/38536840/association-of-spironolactone-use-with-risk-of-urinary-tract-cancer-in-the-general-population-a-matched-population-based-cohort-study
#1
JOURNAL ARTICLE
Liang-Cheng Chen, Hsuan-Ju Yang, Ben-Hui Yu, Moon-Sing Lee, Hon-Yi Lin, Wen-Yen Chiou, Dai-Wei Liu, Feng-Chun Hsu, Chia-Hui Chew, Shih-Kai Hung
PURPOSE: The correlation between spironolactone usage and cancer risk has sparked interest. The objective of this study is to examine the association between spironolactone use and the incidence of urinary tract cancer in the general population. METHODS: We conducted a matched population-based cohort study. The study population was obtained from the Taiwan National Health Insurance Research Database (TNHIRD) during the period from 2000 to 2016. The multivariate Cox proportional hazard model was performed to examine the impact of spironolactone use on the risk of urinary tract cancer...
2024: PloS One
https://read.qxmd.com/read/38534739/ferroptosis-related-lncrna-to-predict-the-clinical-outcomes-and-molecular-characteristics-of-kidney-renal-papillary-cell-carcinoma
#2
JOURNAL ARTICLE
Yubo Gong, Chenchen Zhang, Hao Li, Xiaojie Yu, Yuejia Li, Zhiguo Liu, Ruyi He
Kidney renal papillary cell carcinoma (KIRP) is a highly heterogeneous type of kidney cancer, resulting in limited effective prognostic targets for KIRP patients. Long non-coding RNAs (lncRNAs) have emerged as crucial regulators in the regulation of ferroptosis and iron metabolism, making them potential targets for the treatment and prognosis of KIRP. In this study, we constructed a ferroptosis-related lncRNA risk score model (FRM) based on the TCGA-KIRP dataset, which represents a novel subtype of KIRP not previously reported...
February 29, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38531903/cancer-incidence-trends-in-new-york-state-and-associations-with-common-population-level-exposures-2010-2018-an-ecological-study
#3
JOURNAL ARTICLE
Haokun Yuan, Rebecca D Kehm, Josephine M Daaboul, Susan E Lloyd, Jasmine A McDonald, Lina Mu, Parisa Tehranifar, Kai Zhang, Mary Beth Terry, Wan Yang
The impact of common environmental exposures in combinations with socioeconomic and lifestyle factors on cancer development, particularly for young adults, remains understudied. Here, we leveraged environmental and cancer incidence data collected in New York State at the county level to examine the association between 31 exposures and 10 common cancers (i.e., lung and bronchus, thyroid, colorectal, kidney and renal pelvis, melanoma, non-Hodgkin lymphoma, and leukemia for both sexes; corpus uteri and female breast cancer; prostate cancer), for three age groups (25-49, 50-69, and 70-84 year-olds)...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38530620/sodium-glucose-cotransporter-2-inhibitors-and-cancer-a-systematic-review-and-meta-analysis
#4
JOURNAL ARTICLE
B Xu, B Kang, S Li, S Fan, J Zhou
BACKGROUND: The effect of sodium-glucose cotransporter 2 (SGLT2) inhibitors on cancer has yet to be fully elucidated. OBJECTIVE: This systematic review and meta-analysis investigated the effects of SGLT2 inhibitors on cancer. METHODS: We searched the PubMed and ClinicalTrials.gov databases up to July 15, 2023, to identify eligible randomized, double-blind, placebo-controlled trials that lasted at least ≥24 weeks. The primary outcome was the overall cancer incidence, and the secondary outcomes were the incidences of various types of cancer...
March 26, 2024: Journal of Endocrinological Investigation
https://read.qxmd.com/read/38530480/cancer-specific-mortality-in-non-metastatic-t1a-renal-cell-carcinoma-treated-with-radiotherapy-versus-partial-nephrectomy
#5
JOURNAL ARTICLE
Mario de Angelis, Simone Morra, Lukas Scheipner, Carolin Siech, Letizia Maria Ippolita Jannello, Andrea Baudo, Jordan A Goyal, Zhe Tian, Nicola Longo, Sascha Ahyai, Ottavio de Cobelli, Felix K H Chun, Fred Saad, Shahrokh F Shariat, Luca Carmignani, Francesco Montorsi, Alberto Briganti, Pierre I Karakiewicz
PURPOSE: Radiotherapy (RT) represents a treatment option for small renal masses with proven feasibility and tolerability. However, it has never been directly compared to partial nephrectomy (PN) with cancer-specific mortality (CSM) as an endpoint. METHODS: Within the Surveillance, Epidemiology, and End Results database (2004-2020), we identified T1aN0M0 renal cell carcinoma (RCC) patients treated with RT or PN. We relied on 1:1 propensity score matching (PSM) for age, tumor size and histology...
March 26, 2024: World Journal of Urology
https://read.qxmd.com/read/38529813/water-soluble-phenolics-from-phoenix-dactylifera-fruits-as-potential-reno-protective-agent-against-cisplatin-induced-toxicity-pre-and-post-treatment-strategies
#6
JOURNAL ARTICLE
Omowumi Oyeronke Adewale, Roseline Fadera Oyelola, Oluwatosin Adefunke Adetuyi, Oluwaseun Abraham Adebisi, Damilare Adedayo Adekomi, Johnson Olaleye Oladele
Nephrotoxicity is the major side effect of cisplatin, an effective platinum-based chemotherapeutic drug that is applicable in the treatment of several solid-tissue cancers. Studies have indicated that certain water-soluble phenolics offer renal protection. Thus, this study investigates the role of pre and post-treatment of rats with water-soluble phenolics from Phoenix dactylifera (PdP) against nephrotoxicity induced by cisplatin. Rats were either orally pretreated or post-treated with 200 mg/kg body weight of PdP before or after exposure to a single therapeutic dose of cisplatin (5 mg/kg body weight) for 7 successive days intraperitoneally...
March 26, 2024: Drug and Chemical Toxicology
https://read.qxmd.com/read/38527830/joe-s-story-how-a-capitated-payment-model-lets-me-be-the-physician-i-want-to-be
#7
JOURNAL ARTICLE
Amy C Denham
For many years I cared for Joe, following him through diagnoses of strokes, end-stage renal disease, and metastatic prostate cancer. Gaining his trust, coordinating his care across specialist visits and hospitalizations, and helping him and his family clarify goals of care took an investment of time and relationship-building. I was able to spend this time with Joe, and all of my medically complex patients, because I had taken a job in a Program of All-Inclusive Care for the Elderly (PACE), a fully capitated model of care...
2024: Annals of Family Medicine
https://read.qxmd.com/read/38521146/outcomes-of-acute-ischemic-stroke-among-patients-with-renal-cell-carcinoma-a-nationwide-analysis
#8
JOURNAL ARTICLE
Galadu Subah, Sabrina Zeller, Aarti Jain, Emma Bloom, Saya Mieth, Nimrod Gozum, Austin Li, Fangyi Lin, Anaz Uddin, Stuart Brill, Tarik Al-Bermani, Gurmeen Kaur, Chirag D Gandhi, Fawaz Al-Mufti
INTRODUCTION: Renal cell carcinoma (RCC) has been associated with an increased risk for acute ischemic stroke (AIS). As individuals with cancer who experience AIS tend to face higher mortality rates compared to AIS patients without cancer, recognizing the implications of RCC in AIS is crucial for identifying high-risk patients for major complications and directing management strategies. OBJECTIVE: To examine risk factors, interventions, and outcomes for patients with AIS stratified by their RCC diagnosis...
March 21, 2024: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://read.qxmd.com/read/38517387/identification-and-validation-of-a-novel-signature-based-on-macrophage-marker-genes-for-predicting-prognosis-and-drug-response-in-kidney-renal-clear-cell-carcinoma-by-integrated-analysis-of-single-cell-and-bulk-rna-sequencing
#9
JOURNAL ARTICLE
Xiaoxu Chen, Zheyu Zhang, Zheng Qin, Xiao Zhu, Kaibin Wang, Lijuan Kang, Changying Li, Haitao Wang
Macrophages are found in a variety of tumors and play a critical role in shaping the tumor microenvironment, affecting tumor progression, metastasis, and drug resistance. However, the clinical relevance of marker genes associated with macrophage in kidney renal clear cell carcinoma (KIRC) has yet to be documented. In this study, we initiated a thorough examination of single-cell RNA sequencing (scRNA-seq) data for KIRC retrieved from the Gene Expression Omnibus (GEO) database and determined 244 macrophage marker genes (MMGs)...
March 20, 2024: Aging
https://read.qxmd.com/read/38515689/identification-of-prognostic-models-for-glycosylation-related-subtypes-and-tumor-microenvironment-infiltration-characteristics-in-clear-cell-renal-cell-cancer
#10
JOURNAL ARTICLE
Cheng Shen, Bing Zheng, Zhan Chen, Wei Zhang, Xinfeng Chen, Siyang Xu, Jianfeng Ji, Xingxing Fang, Chunmei Shi
BACKGROUND: One of the most fatal forms of cancer of the urinary system, renal cell carcinoma (RCC), significantly negatively impacts human health. Recent research reveals that abnormal glycosylation contributes to the growth and spread of tumors. However, there is no information on the function of genes related to glycosylation in RCC. METHODS: In this study, we created a technique that can be used to guide the choice of immunotherapy and chemotherapy regimens for RCC patients while predicting their survival prognosis...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38515278/prom2-overexpression-induces-metastatic-potential-through-epithelial-to-mesenchymal-transition-and-ferroptosis-resistance-in-human-cancers
#11
JOURNAL ARTICLE
Justine Paris, Claire Wilhelm, Celeste Lebbé, Mohammed Elmallah, Frédéric Pamoukdjian, Audrey Héraud, Guillaume Gapihan, Aurore Van De Walle, Van Nhan Tran, Diaddin Hamdan, Clara Allayous, Maxime Battistella, Emmanuel Van Glabeke, Kah Wai Lim, Christophe Leboeuf, Sébastien Roger, Géraldine Falgarone, Anh Tuan Phan, Guilhem Bousquet
INTRODUCTION: Despite considerable therapeutic advances in the last 20 years, metastatic cancers remain a major cause of death. We previously identified prominin-2 (PROM2) as a biomarker predictive of distant metastases and decreased survival, thus providing a promising bio-target. In this translational study, we set out to decipher the biological roles of PROM2 during the metastatic process and resistance to cell death, in particular for metastatic melanoma. METHODS AND RESULTS: Methods and results: We demonstrated that PROM2 overexpression was closely linked to an increased metastatic potential through the increase of epithelial-to-mesenchymal transition (EMT) marker expression and ferroptosis resistance...
March 2024: Clinical and Translational Medicine
https://read.qxmd.com/read/38514083/preclinical-characterization-of-dpi-4452-a-68-ga-177-lu-theranostic-ligand-for-carbonic-anhydrase-ix
#12
JOURNAL ARTICLE
Frédéric Massière, Norbert Wiedemann, Inês Borrego, Aileen Hoehne, Frank Osterkamp, Matthias Paschke, Dirk Zboralski, Anne Schumann, Anne Bredenbeck, Franck Brichory, Antoine Attinger
The membrane protein carbonic anhydrase IX (CAIX) is highly expressed in many hypoxic or von Hippel-Lindau tumor suppressor-mutated tumor types. Its restricted expression in healthy tissues makes CAIX an attractive diagnostic and therapeutic target. DPI-4452 is a CAIX-targeting cyclic peptide with a DOTA cage, allowing radionuclide chelation for theranostic purposes. Here, we report CAIX expression in multiple tumor types and provide in vitro and in vivo evaluations of 68 Ga-labeled DPI-4452 ([68 Ga]Ga-DPI-4452) and 177 Lu-labeled DPI-4452 ([177 Lu]Lu-DPI-4452)...
March 21, 2024: Journal of Nuclear Medicine
https://read.qxmd.com/read/38513435/degradation-controlled-tissue-extracellular-sponge-for-rapid-hemostasis-and-wound-repair-after-kidney-injury
#13
JOURNAL ARTICLE
Jae Yun Kim, Tugce Sen, Jae Yeon Lee, Dong-Woo Cho
Patients diagnosed with T1a cancer undergo partial nephrectomy to remove the tumors. In the process of removing the tumors, loss of kidney volume is inevitable, and current surgical methods focus solely on hemostasis and wound closure. Here, we developed an implantable form of decellularized extracellular matrix sponge to target both hemostasis and wound healing at the lesion site. A porous form of kidney decellularized matrix was achieved by fabricating a chemically cross-linked cryogel followed by lyophilization...
March 11, 2024: Biomaterials
https://read.qxmd.com/read/38512983/mice-with-renal-specific-alterations-of-stem-cell-associated-signaling-develop-symptoms-of-chronic-kidney-disease-but-surprisingly-no-tumors
#14
JOURNAL ARTICLE
Adam Myszczyszyn, Oliver Popp, Severine Kunz, Anje Sporbert, Simone Jung, Louis C Penning, Annika Fendler, Philipp Mertins, Walter Birchmeier
Previously, we found that Wnt and Notch signaling govern stem cells of clear cell kidney cancer (ccRCC) in patients. To mimic stem cell responses in the normal kidney in vitro in a marker-unbiased fashion, we have established tubular organoids (tubuloids) from total single adult mouse kidney epithelial cells in Matrigel and serum-free conditions. Deep proteomic and phosphoproteomic analyses revealed that tubuloids resembled renewal of adult kidney tubular epithelia, since tubuloid cells displayed activity of Wnt and Notch signaling, long-term proliferation and expression of markers of proximal and distal nephron lineages...
2024: PloS One
https://read.qxmd.com/read/38511791/comprehensive-prognostic-assessment-in-kidney-cancer-a-multidimensional-approach-analyzing-fufang-sanling-granules-genetic-variants-and-immune-infiltration
#15
JOURNAL ARTICLE
Junlan Zhu, Yun Ye, Xin Zhao, Meiling Wu, Xuyao Wang, Peng Shu, Jian Liu, Xingguo Zhang
This study delves into the potential therapeutic benefits of Fufang Sanling Granules for kidney cancer, focusing on their active components and the underlying mechanisms of their interaction with cancer-related targets. By constructing a drug-active component-target network based on eight herbs, key active compounds such as kaempferol, quercetin, and linolenic acid were identified, suggesting their pivotal roles in modulating immune responses and cellular signaling pathways relevant to cancer progression. The research further identified 51 central drug-disease genes through comprehensive bioinformatics analyses, implicating their involvement in crucial biological processes and pathways...
March 21, 2024: Environmental Toxicology
https://read.qxmd.com/read/38505156/the-challenging-management-of-malignant-ureteral-obstruction-analysis-of-a-series-of-188-cases
#16
JOURNAL ARTICLE
Alberto Artiles Medina, Inés Laso García, Fernando González Tello, Sara Álvarez Rodríguez, Manuel Hevia Palacios, Marina Mata Alcaraz, César Mínguez Ojeda, Fernando Arias Funez, Victoria Gómez Dos Santos, Francisco Javier Burgos Revilla
BACKGROUND: Malignant ureteral obstruction (MUO) is a common condition that complicates the course of advanced malignancies. The aims of this study are to analyze the causes, management, and survival of patients with obstructive nephropathy due to malignant ureteric obstruction and to determine prognostic factors. Furthermore, we studied the complications and outcomes in patients who underwent urinary diversion. MATERIALS AND METHODS: A retrospective study was conducted on patients with computed tomography-confirmed MUO between January 2016 and November 2020...
March 2024: Current Urology
https://read.qxmd.com/read/38504270/unveiling-cxcr2-as-a-promising-therapeutic-target-in-renal-cell-carcinoma-exploring-the-immunotherapeutic-paradigm-shift-through-its-inhibition-by-rct001
#17
JOURNAL ARTICLE
Christopher Montemagno, Arnaud Jacquel, Charlotte Pandiani, Olivia Rastoin, Rosie Dawaliby, Thomas Schmitt, Maxence Bourgoin, Héliciane Palenzuela, Anne-Laure Rossi, Damien Ambrosetti, Jerome Durivault, Frederic Luciano, Delphine Borchiellini, Julie Le Du, Leticia Christina Pires Gonçalves, Patrick Auberger, Rachid Benhida, Lisa Kinget, Benoit Beuselinck, Cyril Ronco, Gilles Pagès, Maeva Dufies
BACKGROUND: In clear cell renal cell carcinoma (ccRCC), first-line treatment combines nivolumab (anti-PD-1) and ipilimumab (anti-CTLA4), yielding long-term remissions but with only a 40% success rate. Our study explored the potential of enhancing ccRCC treatment by concurrently using CXCR2 inhibitors alongside immunotherapies. METHODS: We analyzed ELR + CXCL levels and their correlation with patient survival during immunotherapy. RCT001, a unique CXCR2 inhibitor, was examined for its mechanism of action, particularly its effects on human primary macrophages...
March 19, 2024: Journal of Experimental & Clinical Cancer Research: CR
https://read.qxmd.com/read/38502348/berberine-chloride-suppresses-pancreatic-adenocarcinoma-proliferation-and-growth-by-targeting-inflammation-related-genes-an-in-silico-analysis-with-in-vitro-and-vivo-validation
#18
JOURNAL ARTICLE
Lin-Jie Ruan, Ju-Ying Jiao, Chienshan Cheng, Yuan Zhang, Zhang-Qi Cao, Ba He, Zhen Chen
PURPOSE: Targeting inflammatory crosstalk between tumors and their microenvironment has emerged as a crucial method for suppressing pancreatic adenocarcinoma (PAAD) progression. Berberine (BBR) is a natural pentacyclic isoquinoline alkaloid known for its anti-inflammatory and antitumor pharmacological effects; however, the mechanism underlying PAAD suppression remains unclear. We aim to investigate the effects of BBR on PAAD progression and their underlying mechanisms. METHODS: The prognostic value of inflammation-related genes in PAAD was assessed using bioinformatics analyses, then the pharmacological effects and potential mechanisms of BBR on PAAD will be investigated in silico, in vitro, and in vivo...
March 19, 2024: Cancer Chemotherapy and Pharmacology
https://read.qxmd.com/read/38496822/the-impact-of-histological-variants-on-oncological-outcomes-after-surgical-resection-of-a-nonmetastatic-renal-cell-carcinoma-with-tumor-thrombus-a-multi-institutional-study
#19
JOURNAL ARTICLE
Raphael Fleury, Théophile Bertail, Karim Bensalah, Jean-Christophe Bernhard, Francois Audenet, Thibaut Waeckel, Bastien Parier, Cécile Champy, Jonathan Olivier, Nicolas Doumerc, Thibault Tricard, Nicolas Branger, Franck Bruyere, Paul Neuville, Louis Surlemont, Jean Alexandre Long, Alexis Fontenil, Maxime Vallee, Morgan Roupret, Romain Boissier, Jean Jacques Patard, Mathieu Durand, Idir Ouzaid, Benjamin Rouget, Xavier Durand, Charlotte Joncour, Olivier Belas, Florie Denise Gomez, Pierre Bigot, Zine-Eddine Khene
BACKGROUND: There is no definitive evidence of the prognosis impact of histological variants (HVs) in patients who undergo surgical resection of a nonmetastatic renal cell carcinoma (nm-RCC) with venous tumor thrombus (TT). OBJECTIVE: To investigate the impact of HVs on the prognosis of patients with nm-RCC with TT after radical surgery. DESIGN SETTING AND PARTICIPANTS: Patients who underwent radical nephrectomy with the removal of the venous TT for an nm-RCC were included in a retrospective study...
April 2024: European urology open science
https://read.qxmd.com/read/38495834/integrative-analysis-and-risk-model-construction-for-super%C3%A2-enhancer%C3%A2-related-immune-genes-in-clear-cell-renal-cell-carcinoma
#20
JOURNAL ARTICLE
Zhenyu Bi, Jinghao Zhou, Yan Ma, Qingxin Guo, Boyang Ju, Haoran Zou, Zuhao Zhan, Feihong Yang, Han Du, Xiuguo Gan, Erlin Song
Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer associated with poor prognosis, and accounts for the majority of RCC-related deaths. The lack of comprehensive diagnostic and prognostic biomarkers has limited further understanding of the pathophysiology of ccRCC. Super-enhancers (SEs) are congregated enhancer clusters that have a key role in tumor processes such as epithelial-mesenchymal transition, metabolic reprogramming, immune escape and resistance to apoptosis. RCC may also be immunogenic and sensitive to immunotherapy...
May 2024: Oncology Letters
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