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https://www.readbyqxmd.com/read/28534535/the-potential-of-organoids-in-urological-cancer-research
#1
REVIEW
Shangqian Wang, Dong Gao, Yu Chen
Technical advances in the development of organoid systems enable cell lines, primary adult cells, or stem or progenitor cells to develop into diverse, multicellular entities, which can self-renew, self-organize, and differentiate. These 3D organoid cultures have proven to be of value in increasing our understanding of the biology of disease and offer the potential of regenerative and genetic therapies. The successful application of 3D organoids derived from adult tissue into urological cancer research can further our understanding of these diseases and could also provide preclinical cancer models to realize the precision medicine paradigm by therapeutic screening of individual patient samples ex vivo...
May 23, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/28528291/the-association-of-lifetime-physical-inactivity-with-bladder-and-renal-cancer-risk-a-hospital-based-case-control-analysis
#2
Rikki Cannioto, John Lewis Etter, Lauren Beryl Guterman, Janine M Joseph, Nicholas R Gulati, Kristina L Schmitt, Michael J LaMonte, Ryan Nagy, Albina Minlikeeva, James Brian Szender, Kirsten B Moysich
OBJECTIVES: Recreational physical inactivity has been gaining recognition as an independent epidemiological exposure of interest in relation to cancer endpoints due to evidence suggesting that it may associate with cancer independent of obesity. In the current analyses, we examined the associations of lifetime recreational physical inactivity with renal and bladder cancer risk. METHODS: In this hospital-based case-control study, we identified N=160 renal cancer patients, N=208 bladder cancer patients, and N=766 age frequency-matched controls without cancer...
May 18, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28526733/discovery-and-optimization-of-hkt288-a-cadherin-6-targeting-adc-for-the-treatment-of-ovarian-and-renal-cancer
#3
Carl U Bialucha, Scott D Collins, Xiao Li, Parmita Saxena, Xiamei Zhang, Clemens Dürr, Bruno LaFont, Pierric Prieur, Yeonju Shim, Rebecca Mosher, David Lee, Lance Ostrom, Tiancen Hu, Sanela Bilic, Ivana Liric Rajlic, Vladimir Capka, Wei Jiang, Joel P Wagner, GiNell Elliott, Artur Veloso, Jessica C Piel, Meghan M Flaherty, Keith G Mansfield, Emily K Meseck, Tina Rubic-Schneider, Anne Serdakowski London, William R Tschantz, Markus Kurz, Duc Nguyen, Aaron Bourret, Matthew J Meyer, Jason E Faris, Mary J Janatpour, Vivien W Chan, Nicholas C Yoder, Kalli C Catcott, Molly A McShea, Xiuxia Sun, Hui Gao, Juliet Williams, Francesco Hofmann, Jeffrey A Engelman, Seth A Ettenberg, William R Sellers, Emma Lees
Despite an improving therapeutic landscape, significant challenges remain in treating the majority of advanced ovarian and renal cancer patients. We identified the cell-cell adhesion molecule cadherin-6 (CDH6) as a lineage gene having significant differential expression in ovarian and kidney cancer. HKT288 is an optimized CDH6-targeting DM4-based antibody drug conjugate (ADC) developed for the treatment of these diseases. Our study provides mechanistic evidence supporting the importance of linker choice for optimal anti-tumor activity and highlights CDH6 as a novel antigen for biotherapeutic development...
May 19, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28521783/association-of-post-treatment-hypoalbuminemia-and-survival-in-chinese-patients-with-metastatic-renal-cell-carcinoma
#4
Wen Cai, Jin Zhang, Yonghui Chen, Wen Kong, Yiran Huang, Jiwei Huang, Lixin Zhou
BACKGROUND: Hypoalbuminemia adversely affects the clinical outcomes of various cancers. The purpose of this study was to estimate the prognostic value of hypoalbuminemia 3-5 weeks after treatment in patients with metastatic renal cell carcinoma (mRCC) who received sorafenib or sunitinib as first-line treatment. METHODS: In this single-center, retrospective study, we assessed the progression-free survival (PFS) and overall survival (OS) of 184 mRCC patients who received first-line sorafenib or sunitinib treatment...
May 18, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28520840/assessment-of-nivolumab-benefit-risk-profile-of-a-240-mg-flat-dose-relative-to-a-3-mg-kg-dosing-regimen-in-patients-with-advanced-tumors
#5
X Zhao, S Suryawanshi, M Hruska, Y Feng, X Wang, J Shen, H E Vezina, M B McHenry, I M Waxman, A Achanta, A Bello, A Roy, S Agrawal
Background: : Nivolumab 3 mg/kg every 2 weeks (Q2W) has shown benefit versus the standard of care in melanoma, non-small cell lung cancer (NSCLC), and renal cell carcinoma (RCC). However, flat dosing is expected to shorten preparation time and improve ease of administration. With knowledge of nivolumab safety, efficacy, and pharmacokinetics across a wide dose range in BW dosing, assessment of the benefit-risk profile of a 240-mg flat dose relative to the approved 3-mg/kg dose was approached by quantitative clinical pharmacology...
May 17, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28515098/collagen-turnover-markers-in-relation-to-future-cardiovascular-and-noncardiovascular-disease-the-multi-ethnic-study-of-atherosclerosis
#6
Daniel A Duprez, Myron D Gross, Otto A Sanchez, Jorge R Kizer, Joachim H Ix, Joao Lima, Russell P Tracy, David R Jacobs
BACKGROUND: Sustained remodeling of extracellular matrix can compromise organs and tissues. Procollagen type III N-terminal propeptide (PIIINP) and collagen type I carboxy-terminal telopeptide (ICTP) reflect collagen synthesis and degradation. We studied their predictive value for future death and disease. METHODS: A total of 3068 men and women in the Multi-Ethnic Study of Atherosclerosis who were free of cardiovascular disease (CVD) and in generally good health had a baseline blood sample taken for ICTP and PIIINP...
May 17, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28514898/assessment-of-cryosurgical-device-performance-using-a-3d-tissue-engineered-cancer-model
#7
John M Baust, Anthony Robilotto, Kristi K Snyder, Kimberly Santucci, Jennie Stewart, Robert Van Buskirk, John G Baust
As the clinical use of cryoablation for the treatment of cancer has increased, so too has the need for knowledge on the dynamic environment within the frozen mass created by a cryoprobe. While a number of factors exist, an understanding of the iceball size, critical isotherm distribution/penetration, and the resultant lethal zone created by a cryoprobe are critical for clinical application. To this end, cryoprobe performance is typically characterized based on the iceball size and temperature penetration in phantom gel models...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28511884/the-impact-of-quality-variations-on-patients-undergoing-surgery-for-renal-cell-carcinoma-a-national-cancer-database-study
#8
Keith A Lawson, Olli Saarela, Robert Abouassaly, Simon P Kim, Rodney H Breau, Antonio Finelli
BACKGROUND: Despite efforts to define metrics assessing hospital-level quality for renal cell carcinoma (RCC) surgical care there remains a paucity of real-world data validating their ability to benchmark performance. Consequently, whether poor performance on hospital-level quality indicators is associated with inferior patient outcomes remains unknown. OBJECTIVES: To determine hospital-level variations in RCC surgical quality after adjusting for differences in patient- and tumor-specific factors...
May 13, 2017: European Urology
https://www.readbyqxmd.com/read/28511073/preparation-and-evaluation-of-l-and-d-5-18-f-fluorotryptophan-as-pet-imaging-probes-for-indoleamine-and-tryptophan-2-3-dioxygenases
#9
Tang Tang, Herman S Gill, Annie Ogasawara, Jeff N Tinianow, Alexander N Vanderbilt, Simon-Peter Williams, Georgia Hatzivassiliou, Sharla White, Wendy Sandoval, Kevin DeMent, Mengling Wong, Jan Marik
Indoleamine and tryptophan 2,3-dioxygenases (IDO1 and TDO2) are pyrrolases catalyzing the oxidative cleavage of the 2,3-double bond of L-tryptophan in kynurenine pathway. In the tumor microenvironment, their increased activity prevents normal immune function, i.e. tumor cell recognition and elimination by cytotoxic T-cells. Consequently, inhibition of the kynurenine pathway may enhance the activity of cancer immunotherapeutics by reversing immune dysfunction. We sought to investigate the properties of radiolabeled 5-[(18)F]fluorotryptophan with respect to its ability for measuring IDO1 and TDO2 activity by positron emission tomography (PET)...
May 5, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28503232/cytoreductive-nephrectomy-in-the-modern-era-predictors-of-use-morbidity-and-survival
#10
Brian J Minnillo, William Tabayoyong, John J Francis, Matthew J Maurice, Hui Zhu, Simon Kim, Robert Abouassaly
INTRODUCTION: To determine tumour, patient, and provider factors associated with cytoreductive nephrectomy (CN) use and to identify those factors that predicted short-term and long-term surgical outcomes. METHODS: We performed a retrospective review (1998-2011) of the National Cancer Database, a U.S. population-based oncology outcomes database. The review included 36 549 patients with metastatic renal cell carcinoma (mRCC). We assessed predictors of CN use, length of stay (LOS), 30-day readmission, and 30-day mortality using multivariable logistic regression...
May 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28495554/collecting-duct-carcinoma-of-the-kidney-disease-characteristics-and-treatment-outcomes-from-the-national-cancer-database
#11
Wilson Sui, Justin T Matulay, Dennis J Robins, Maxwell B James, Ifeanyi C Onyeji, Arindam RoyChoudhury, Sven Wenske, Guarionex Joel DeCastro
OBJECTIVE: To use a large population-level database to assess survival outcomes for collecting duct renal cell carcinoma (CDRCC). MATERIALS AND METHODS: The National Cancer Database was queried for all cases of CDRCC and clear cell renal cell carcinoma (CCRCC) from 2004 to 2013. After removing patients with other cancer diagnoses, the analytic cohort was composed of 201,686 CCRCC and 577 CDRCC cases. Kaplan-Meier and cox proportional hazards analysis were employed to model survival...
May 8, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28494338/simultaneous-analysis-of-regorafenib-and-sorafenib-and-three-of-their-metabolites-in-human-plasma-using-lc-ms-ms
#12
Marie Allard, Nihel Khoudour, Benoît Rousseau, Charlotte Joly, Charlotte Costentin, Benoît Blanchet, Christophe Tournigand, Anne Hulin
A new liquid chromatography-tandem mass spectrometry (LC-MS/MS) method, performed by electrospray ionization in positive mode using a triple quadrupole mass spectrometry, has been developed and validated for the simultaneous determination of regorafenib (REGO), its two metabolites regorafenib-M2 and regorafenib-M5, sorafenib (SORA), and its N-oxide metabolite in human plasma. Separation is achieved on an Hypersil Gold(®) column using a gradient elution of 10mM ammonium formate containing 0.1% formic acid (A) and acetonitrile containing 0...
May 1, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28491887/risk-factors-for-surgical-site-infection-after-cholecystectomy
#13
David K Warren, Katelin B Nickel, Anna E Wallace, Daniel Mines, Fang Tian, William J Symons, Victoria J Fraser, Margaret A Olsen
BACKGROUND: There are limited data on risk factors for surgical site infection (SSI) after open or laparoscopic cholecystectomy. METHODS: A retrospective cohort of commercially insured persons aged 18-64 years was assembled using International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) procedure or Current Procedural Terminology, 4th edition codes for cholecystectomy from December 31, 2004 to December 31, 2010. Complex procedures and patients (eg, cancer, end-stage renal disease) and procedures with pre-existing infection were excluded...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28489768/prevalence-of-comorbidities-in-chronic-obstructive-pulmonary-disease-patients-a-meta-analysis
#14
Hong-Lei Yin, Shi-Qi Yin, Qing-Yan Lin, Ying Xu, Hong-Wei Xu, Tao Liu
BACKGROUND: This study compares the prevalence rates of comorbidities between chronic obstructive pulmonary disease (COPD) and non-COPD control patients reported in literature. METHOD: Literature was searched in several electronic databases. After the selection of studies by following précised eligibility criteria, meta-analyses of odds ratios (ORs) were carried out with subgroup and sensitivity analyses under random effects model. RESULTS: Eleven studies (47,695,183 COPD and 47,924,876 non-COPD control patients' data) were used for meta-analysis...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28489074/analysis-of-renal-cancer-cell-lines-from-two-major-resources-enables-genomics-guided-cell-line-selection
#15
Rileen Sinha, Andrew G Winer, Michael Chevinsky, Christopher Jakubowski, Ying-Bei Chen, Yiyu Dong, Satish K Tickoo, Victor E Reuter, Paul Russo, Jonathan A Coleman, Chris Sander, James J Hsieh, A Ari Hakimi
The utility of cancer cell lines is affected by the similarity to endogenous tumour cells. Here we compare genomic data from 65 kidney-derived cell lines from the Cancer Cell Line Encyclopedia and the COSMIC Cell Lines Project to three renal cancer subtypes from The Cancer Genome Atlas: clear cell renal cell carcinoma (ccRCC, also known as kidney renal clear cell carcinoma), papillary (pRCC, also known as kidney papillary) and chromophobe (chRCC, also known as kidney chromophobe) renal cell carcinoma. Clustering copy number alterations shows that most cell lines resemble ccRCC, a few (including some often used as models of ccRCC) resemble pRCC, and none resemble chRCC...
May 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/28487672/the-g-protein-coupled-receptor-ut-of-the-neuropeptide-urotensin-ii-displays-structural-and-functional-chemokine-features
#16
REVIEW
Hélène Castel, Laurence Desrues, Jane-Eileen Joubert, Marie-Christine Tonon, Laurent Prézeau, Marie Chabbert, Fabrice Morin, Pierrick Gandolfo
The urotensinergic system was previously considered as being linked to numerous physiopathological states, including atherosclerosis, heart failure, hypertension, pre-eclampsia, diabetes, renal disease, as well as brain vascular lesions. Thus, it turns out that the actions of the urotensin II (UII)/G protein-coupled receptor UT system in animal models are currently not predictive enough in regard to their effects in human clinical trials and that UII analogs, established to target UT, were not as beneficial as expected in pathological situations...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28476528/prognostic-heterogeneity-in-t3an0m0-renal-cell-carcinoma-according-to-the-site-of-invasion
#17
Myungchan Park, Myungsun Shim, Myong Kim, Cheryn Song, Choung-Soo Kim, Hanjong Ahn
PURPOSE: We investigated the influence of the site of invasion on recurrence and survival in patients with pT3aN0M0 renal cell carcinoma (RCC). MATERIALS AND METHODS: We reviewed the data of 266 patients with pT3aN0M0 RCC who underwent nephrectomy and divided them into the following 5 groups according to the site of invasion: perinephric invasion (PNI), sinus fat invasion (SFI), PNI and SFI without renal vein invasion (RVI) (i.e., PNI+SFI), RVI, and RVI with PNI and/or SFI (RVI+PNI±SFI)...
May 2, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28472893/prevalence-and-related-factors-of-irregular-menstrual-cycles-in-korean-women-the-5th-korean-national-health-and-nutrition-examination-survey-knhanes-v-2010-2012
#18
Eun-Kyung Jung, Seok-Won Kim, Sun-Myeong Ock, Kyu-In Jung, Chan-Hee Song
INTRODUCTION: There have been few population-based studies reporting medical, lifestyle and psychological factors associated with irregular menstrual cycles. This study aimed to elucidate the prevalence and related factors of irregular menstrual cycles in Korean women. METHODS: Cross-sectional data from the 5th Korean National Health and Nutrition Examination Survey were used. Eligible women were 19-40 years old, not currently taking oral contraceptives or using intrauterine devices, and not currently pregnant or breast feeding, and had no medical history of hysterectomy, thyroid diseases, cancers or renal failure...
May 4, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28472770/modeling-african-american-prostate-adenocarcinoma-by-inducing-defined-genetic-alterations-in-organoids
#19
Kenji Unno, Meejeon Roh, Young A Yoo, Yousef Al-Shraideh, Lu Wang, Larisa Nonn, Sarki A Abdulkadir
Genomic studies are rapidly identifying genetic alterations in human cancer, but functional validation of such alterations has been slow. Here, using human prostate cancer as a model, we have assessed the feasibility of engineering defined genetic alterations in well-known cancer driver genes to transform benign prostate epithelial organoids derived from African American men. Benign human prostate organoids were transduced with lentiviruses expressing MYC, shPTEN, shTP53 and AR, alone and in various combinations, to recapitulate prostate cancer development...
April 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28470345/lncrna-ccat1-inhibits-cell-apoptosis-of-renal-cell-carcinoma-through-up-regulation-of-livin-protein
#20
Shaoan Chen, Pengpeng Ma, Bin Li, Dawei Zhu, Xiude Chen, Yuzhu Xiang, Tengteng Wang, Xiangbin Ren, Chuan Liu, Xunbo Jin
This study was to investigate the involvement of long non-coding RNA (lncRNA) colon cancer-associated transcript-1 (CCAT1) in renal cell carcinoma (RCC) and to further uncover its underlying mechanism. In this study, the expression of CCAT1 and Livin of RCC tissues or cells was determined using qRT-PCR (quantitative real-time PCR) and western blot, respectively. RNA pulldown and RIP (RNA-Binding Protein Immunoprecipitation) assays were performed to examine the sequence interaction between CCAT1 and Livin. The viability and apoptosis of RCC cells was assessed by MTT(3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and TUNEL (TdT-mediated dUTP nick end labeling) assays, respectively...
May 3, 2017: Molecular and Cellular Biochemistry
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