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https://www.readbyqxmd.com/read/29680768/utilization-of-stereotactic-radiosurgery-for-renal-cell-carcinoma-brain-metastases
#1
Waqar Haque, Vivek Verma, E Brian Butler, Bin S Teh
BACKGROUND: Because renal cell carcinoma (RCC) has been traditionally considered a "radioresistant" histology, it may be advantageous to treat brain metastases (BMs) with ablative dosing by means of stereotactic radiosurgery (SRS). This is the first known analysis evaluating utilization of SRS for RCC BMs in the United States. METHODS: The National Cancer Data Base was queried (2005-2014) for metastatic RCC and delivery of intracranial radiotherapy. Patients were stratified into groups receiving either SRS or non-SRS treatment...
April 3, 2018: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29678631/platelet-to-lymphocyte-ratio-in-advanced-cancer-review-and-meta-analysis
#2
REVIEW
Bo Li, Pingting Zhou, Yujie Liu, Haifeng Wei, Xinghai Yang, Tianrui Chen, Jianru Xiao
BACKGROUND: Inflammation biomarkers have been introduced into clinical practice for risk-rating in treatment of patients with cancer. We aimed to confirm the prognostic role of platelet-to-lymphocyte ratio (PLR) as a powerful biomarker for patients with advanced cancer. METHOD: A systematic literature search was conducted through PubMed, Embase and Web of Science databases for studies on advanced tumors. Research articles that analyzed the PLR and hazard ratios (HR) in patients with overall survival (OS) or progression-free survival (PFS) data were involved...
April 17, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29669465/superiority-of-rat-over-murine-model-for-studies-on-the-evolution-of-cancer-genome
#3
Shinya Akatsuka, Guang Hua Li, Shinya Toyokuni
Evolution of the species and carcinogenesis are similar in that genomic alterations are the key events. Oxidative stress derived from various etiologies is one of the major causes of carcinogenesis by inducing mutations in the genome. Persistent oxidative stress in the renal proximal tubules through Fenton reaction catalyzed by ferric nitrilotriacetate (Fe-NTA) generates renal cell carcinoma (RCC) in mice and rats. Here, in order to observe the species difference in oxidative stress-induced carcinogenesis and to obtain an insight regarding the characteristics of each species, we compared the genomic alterations using array-based comparative genome hybridization among RCCs in Mutyh knockout/wild-type mice (C57BL/6 background) induced by Fe-NTA, RCCs in F1 hybrids of Brown-Norway/Fischer-344 wild-type rats and clear cell renal cell carcinoma (CCRCC)/papillary renal cell carcinoma (PRCC) of humans...
April 18, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29667174/impact-of-prior-cancer-history-on-the-overall-survival-of-patients-newly-diagnosed-with-cancer-a-pan-cancer-analysis-of-the-seer-database
#4
Huaqiang Zhou, Yan Huang, Zeting Qiu, Hongyun Zhao, Wenfeng Fang, Yunpeng Yang, Yuanyuan Zhao, Xue Hou, Yuxiang Ma, Shaodong Hong, Ting Zhou, Yaxiong Zhang, Li Zhang
The population of cancer survivors with prior cancer is rapidly growing. Whether a prior cancer diagnosis interferes with outcome is unknown. We conducted a pan-cancer analysis to determine the impact of prior cancer history for patients newly diagnosed with cancer. We identified 20 types of primary solid tumors between 2004 to 2008 in the Surveillance, Epidemiology, and End Results (SEER) database. Demographic and clinicopathologic variables were compared by chi-squared test and t-test as appropriate. The propensity score-adjusted Kaplan-Meier method and Cox proportional hazards models were used to evaluate the impact of prior cancer on overall survival (OS)...
April 18, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29667067/a-first-in-class-inhibitor-mln4924-pevonedistat-induces-cell-cycle-arrest-senescence-and-apoptosis-in-human-renal-cell-carcinoma-by-suppressing-ube2m-dependent-neddylation-modification
#5
Bo Xu, Yuyou Deng, Ran Bi, Haoran Guo, Chang Shu, Neelam Kumari Shah, Junliang Chang, Guanchen Liu, Yujun Du, Wei Wei, Chunxi Wang
PURPOSE: MLN4924 is a second-generation inhibitor that targets ubiquitin-proteasome system by inhibiting neddylation activation enzyme (NAE), and subsequently blocking the neddylation-dependent activation of Cullin-RING E3 ligases (CRLs), which leads to the accumulation of CRLs substrates and hence, suppressing diverse tumor development. In this study, we investigated the potential application of this first-in-class inhibitor MLN4924 in the treatment of human renal cell carcinoma both in vitro and in vivo...
April 17, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29665011/colony-stimulating-factor-1-receptor-blockade-improves-the-efficacy-of-chemotherapy-against-human-neuroblastoma-in-the-absence-of-t-lymphocytes
#6
Matthew W Webb, Jianping Sun, Michael A Sheard, Wei-Yao Liu, Hong-Wei Wu, Jeremy R Jackson, Jemily Malvar, Richard Sposto, Dylan Daniel, Robert C Seeger
Tumor-associated macrophages can promote growth of cancers. In neuroblastoma, tumor-associated macrophages have greater frequency in metastatic versus loco-regional tumors, and higher expression of genes associated with macrophages helps to predict poor prognosis in the 60% of high-risk patients who have MYCN-non-amplified disease. The contribution of cytotoxic T-lymphocytes to anti-neuroblastoma immune responses may be limited by low MHC class I expression and low exonic mutation frequency. Therefore, we modelled human neuroblastoma in T-cell deficient mice to examine whether depletion of monocytes/macrophages from the neuroblastoma microenvironment by blockade of CSF-1R can improve the response to chemotherapy...
April 17, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29656891/timing-the-landmark-events-in-the-evolution-of-clear-cell-renal-cell-cancer-tracerx-renal
#7
Thomas J Mitchell, Samra Turajlic, Andrew Rowan, David Nicol, James H R Farmery, Tim O'Brien, Inigo Martincorena, Patrick Tarpey, Nicos Angelopoulos, Lucy R Yates, Adam P Butler, Keiran Raine, Grant D Stewart, Ben Challacombe, Archana Fernando, Jose I Lopez, Steve Hazell, Ashish Chandra, Simon Chowdhury, Sarah Rudman, Aspasia Soultati, Gordon Stamp, Nicos Fotiadis, Lisa Pickering, Lewis Au, Lavinia Spain, Joanna Lynch, Mark Stares, Jon Teague, Francesco Maura, David C Wedge, Stuart Horswell, Tim Chambers, Kevin Litchfield, Hang Xu, Aengus Stewart, Reza Elaidi, Stéphane Oudard, Nicholas McGranahan, Istvan Csabai, Martin Gore, P Andrew Futreal, James Larkin, Andy G Lynch, Zoltan Szallasi, Charles Swanton, Peter J Campbell
Clear cell renal cell carcinoma (ccRCC) is characterized by near-universal loss of the short arm of chromosome 3, deleting several tumor suppressor genes. We analyzed whole genomes from 95 biopsies across 33 patients with clear cell renal cell carcinoma. We find hotspots of point mutations in the 5' UTR of TERT, targeting a MYC-MAX-MAD1 repressor associated with telomere lengthening. The most common structural abnormality generates simultaneous 3p loss and 5q gain (36% patients), typically through chromothripsis...
April 4, 2018: Cell
https://www.readbyqxmd.com/read/29653222/gemcitabine-loaded-microbubbles-for-targeted-chemo-sonodynamic-therapy-of-pancreatic-cancer
#8
Heather Nesbitt, Yingjie Sheng, Sukanta Kamila, Keiran Logan, Keith Thomas, Bridgeen Callan, Mark A Taylor, Mark Love, Declan O'Rourke, Paul Kelly, Estelle Beguin, Eleanor Stride, Anthony P McHale, John F Callan
Pancreatic cancer remains one of the most lethal forms of cancer with a 10-year survival of <1%. With little improvement in survival rates observed in the past 40 years, there is a significant need for new treatments or more effective strategies to deliver existing treatments. The antimetabolite gemcitabine (Gem) is the most widely used form of chemotherapy for pancreatic cancer treatment, but is known to produce significant side effects when administered systemically. We have previously demonstrated the benefit of combined chemo-sonodynamic therapy (SDT), delivered using oxygen carrying microbubbles (O2 MB), as a targeted treatment for pancreatic cancer in a murine model of the disease...
April 11, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29651226/dna-methylation-affects-metastasis-of-renal-cancer-and-is-associated-with-tgf-%C3%AE-runx3-inhibition
#9
Jianbo Zheng, Yanhui Mei, Ping Xiang, Guangsheng Zhai, Ning Zhao, Chuanbing Xu, Min Liu, Zhengsheng Pan, Kai Tang, Dongsheng Jia
Background: Renal cell carcinoma accounts for 2-3% of all cancers and metastasis increased the malignancy of renal cancer. However, the role of methylation in metastasis of renal cancer is poorly understood. Methods: We performed targeted gene array to compare the differential expressions of methylation regulated genes in metastatic and primary renal cancer tissues. Quantitative methylation specific PCR was performed to examine the CpG methylation levels of Runt related transcription factor 3 (RUNX3) and transforming growth factor (TGF)-β...
2018: Cancer Cell International
https://www.readbyqxmd.com/read/29651023/generation-of-autochthonous-mouse-models-of-clear-cell-renal-cell-carcinoma-mouse-models-of-renal-cell-carcinoma
#10
REVIEW
Weibin Hou, Zhigang Ji
Renal cell carcinoma (RCC) is one of the 10 most common cancers worldwide, and to date, a strong systemic therapy has not been developed to treat RCC, even with the remarkable modern advances in molecular medicine mostly due to our incomplete understanding of its tumorigenesis. There is a dire unmet need to understand the etiology and progression of RCC, especially the most common subtype, clear cell RCC (ccRCC), and to develop new treatments for RCC. Genetically engineered mouse (GEM) models are able to mimic the initiation, progression, and metastasis of cancer, thus providing valuable insights into tumorigenesis and serving as perfect preclinical platforms for drug testing and biomarker discovery...
April 13, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29648579/capn4-contributes-to-tumor-invasion-and-metastasis-in-clear-cell-renal-cell-carcinoma-cells-via-modulating-talin-focal-adhesion-kinase-signaling-pathway
#11
Qianfeng Zhuang, Weiping Luo, Mingran Zhang, Min Fan, Hao Lu, Renfang Xu, Xiaozhou He
Calpain small subunit 1 (Capn4) has been shown to correlate with the metastasis/invasion of clear cell renal cell carcinoma (ccRCC). This study aimed to further elucidate the molecular mechanisms underlying Capn4-mediated ccRCC progression. The messenger RNA expression levels in ccRCC cells were measured by quantitative real-time PCR. The effects of Capn4 on cell adhesion, invasion, and migration were examined by cell adhesion assay, cell invasion assay, and wound-healing assay, respectively. The protein levels were detected by western blot analysis...
April 10, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29642374/cancer-mortality-in-residents-of-the-cadmium-polluted-jinzu-river-basin-in-toyama-japan
#12
Muneko Nishijo, Hideaki Nakagawa, Yasushi Suwazono, Kazuhiro Nogawa, Masaru Sakurai, Masao Ishizaki, Teruhiko Kido
After 26 years, we followed up 7348 participants in a 1979-1984 health screening survey in the Jinzu River basin, the heaviest cadmium-polluted area in Japan. We assessed the associations of cadmium exposure levels and mortality from cancer and renal damage, indicated by records of proteinuria and glucosuria in the original survey. Mortality risks (hazard ratios) were analyzed using the Cox proportional hazards model, stratified by sex, after adjusting for age, smoking status, and hypertension, as indicated in the original survey records...
April 6, 2018: Toxics
https://www.readbyqxmd.com/read/29625756/active-surveillance-for-localized-renal-masses-tumor-growth-delayed-intervention-rates-and-5-yr-clinical-outcomes
#13
Andrew G McIntosh, Benjamin T Ristau, Karen Ruth, Rachel Jennings, Eric Ross, Marc C Smaldone, David Y T Chen, Rosalia Viterbo, Richard E Greenberg, Alexander Kutikov, Robert G Uzzo
BACKGROUND: Active surveillance (AS) has gained acceptance as a management strategy for localized renal masses. OBJECTIVE: To review our large single-center experience with AS. DESIGN, SETTING, AND PARTICIPANTS: From 2000 to 2016, we identified 457 patients with 544 lesions managed with AS from our prospectively maintained kidney cancer database. A subset analysis was performed for patients with ≥5-yr follow-up without delayed intervention (DI)...
April 3, 2018: European Urology
https://www.readbyqxmd.com/read/29625271/tyrosine-kinase-inhibition-effects-of-novel-pyrazolo-1-5-a-pyrimidines-and-pyrido-2-3-d-pyrimidines-ligand-synthesis-biological-screening-and-molecular-modeling-studies
#14
Mardia T El Sayed, Hoda A R Hussein, Nora M Elebiary, Ghada S Hassan, Shahenda M Elmessery, Ahmed R Elsheakh, Mohamed Nayel, Hatem A Abdel-Aziz
Tyrosine kinases are one of the most critical mediators in the signaling path way. Late studies have proved the part of tyrosine kinases in the pathophysiology of cancer diseases. This current research paper has focused on investigating the novel Pyrazolo[1,5-a]pyrimidines and Pyrido[2,3-d]pyrimidines as a small molecules that can inhibit tyrosine kinase in cancer cells. NCI protocol was applied to test the antitumor activity of such compounds. Leukemia and renal cancer cell lines proved to be sensitive to some derivatives such as 6b-d, 9a and 11 with GI% values ranging from 30...
March 26, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29610121/response-to-erbb3-directed-targeted-therapy-in-nrg1-rearranged-cancers
#15
Alexander Drilon, Romel Somwar, Biju P Mangatt, Henrik Edgren, Patrice Desmeules, Anja Ruusulehto, Roger S Smith, Lukas Delasos, Morana Vojnic, Andrew J Plodkowski, Joshua Sabari, Kenneth Ng, Joseph Montecalvo, Jason Chang, Huichun Tai, William W Lockwood, Victor Martinez, Gregory J Riely, Charles M Rudin, Mark G Kris, Maria E Arcila, Christopher Matheny, Ryma Benayed, Natasha Rekhtman, Marc Ladanyi, Gopinath Ganji
NRG1 rearrangements are oncogenic drivers that are enriched in invasive mucinous adenocarcinomas (IMAs) of the lung. The oncoprotein binds ERBB3-ERBB2 heterodimers and activates downstream signaling, supporting a therapeutic paradigm of ERBB3/ERBB2 inhibition. As proof of concept, a durable response was achieved with anti-ERBB3 monoclonal antibody therapy (GSK2849330) in an exceptional responder with an NRG1-rearranged IMA on a phase 1 trial (NCT01966445). In contrast, response was not achieved with anti-ERBB2 therapy (afatinib) in four NRG1-rearranged IMA patients (including the index patient post-GSK2849330)...
April 2, 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29603918/the-effect-of-age-on-cancer-specific-mortality-in-patients-with-small-renal-masses-a-population-based-analysis
#16
Marco Bandini, Michele Marchioni, Raisa S Pompe, Zhe Tian, Tristan Martel, Felix K Chun, Luca Cindolo, Anil Kapoor, Francesco Montorsi, Shahrokh F Shariat, Alberto Briganti, Pierre I Karakiewicz
INTRODUCTION: Contemporary data regarding the effect of age, especially in the elderly patients, on cancer-specific mortality (CSM) for pT1a renal cell cancer (RCC) are lacking. The objective of the current study is to evaluate CSM in a large population-based cohort of surgically treated pT1a RCC patients according to age groups. METHODS: Within the Surveillance Epidemiology and End Results database (2000-2013), we identified 37 121 pT1a RCC patients who underwent either partial or radical nephrectomy...
March 19, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29602840/vitamin-d-obesity-and-leptin-in-relation-to-bladder-cancer-incidence-and-survival-prospective-protocol-study
#17
Randi Elin Gislefoss, Jo Steinson Stenehjem, Helga Helseth Hektoen, Bettina Kulle Andreassen, Hilde Langseth, Karol Axcrona, Elisabete Weiderpass, Alison Mondul, Trude Eid Robsahm
INTRODUCTION: Bladder cancer (BC) (including renal pelvis, ureter and urethra) is one of the most common urogenital cancers and the fourth most frequent cancer in men in the USA. In Norway, the incidence of BC has increased over the last decades. The age-standardised incidence rates per 100 000 for 2011-2015 were 53.7 in men and 16.5 in women. Compared to the 5-year period 2006-2010, the percentage increase in incidence was 6.1% in men and 12.3% in women. The recurrence rate of BC is over 50%, the highest recurrence rate of any malignancy...
March 30, 2018: BMJ Open
https://www.readbyqxmd.com/read/29599927/the-prognostic-value-of-cxc-chemokine-receptor-2-cxcr2-in-cancers-a-meta-analysis
#18
Bingbing Qiao, Wenqin Luo, Yanna Liu, Jing Wang, Chuan Liu, Zhao Liu, Sizhe Chen, Jingjing Gu, Xiaolong Qi, Tongwei Wu
Background & Aims: Quite a few studies had investigated the correlation between CXC chemokine receptor 2 (CXCR2) and cancer. This meta-analysis was aimed to comprehensively summarize the previous studies and to explore the prognostic value of CXCR2 in patients with cancer. Materials and Methods: An adequate literature search in EMBASE and PubMed was conducted. Articles in English which have reported CXCR2 expression in patients and enough data to calculate hazard ratio (HR) were included...
March 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29590600/response-of-single-cells-to-shock-waves-and-numerically-optimized-waveforms-for-cancer-therapy
#19
Dongli Li, Antonio Pellegrino, Andre Hallack, Nik Petrinic, Antoine Jérusalem, Robin O Cleveland
Shock waves are used clinically for breaking kidney stones and treating musculoskeletal indications. The mechanisms by which shock waves interact with tissue are still not well understood. Here, ultra-high-speed imaging was used to visualize the deformation of individual cells embedded in a tissue-mimicking phantom when subject to shock-wave exposure from a clinical source. Three kidney epithelial cell lines were considered to represent normal healthy (human renal epithelial), cancer (CAKI-2), and virus-transformed (HK-2) cells...
March 27, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29581861/the-circadian-clock-regulates-cisplatin-induced-toxicity-and-tumor-regression-in-melanoma-mouse-and-human-models
#20
Panshak P Dakup, Kenneth I Porter, Alexander A Little, Rajendra P Gajula, Hui Zhang, Elena Skornyakov, Michael G Kemp, Hans P A Van Dongen, Shobhan Gaddameedhi
Cisplatin is one of the most commonly used chemotherapeutic drugs; however, toxicity and tumor resistance limit its use. Studies using murine models and human subjects have shown that the time of day of cisplatin treatment influences renal and blood toxicities. We hypothesized that the mechanisms responsible for these outcomes are driven by the circadian clock. We conducted experiments using wild-type and circadian disrupted Per1/2-/- mice treated with cisplatin at selected morning (AM) and evening (PM) times...
March 6, 2018: Oncotarget
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