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Irene Gracia-Rubio, Maria Moscoso-Castro, Oscar J Pozo, Josep Marcos, Roser Nadal, Olga Valverde
Early life experiences play a key role in brain function and behaviour. Adverse events during childhood are therefore a risk factor for psychiatric disease during adulthood, such as mood disorders. Maternal separation is a validated mouse model for maternal neglect, producing negative early life experiences that result in subsequent emotional alteration. Mood disorders have been found to be associated with neurochemical changes and neurotransmitter deficits such as reduced availability of monoamines in discrete brain areas...
February 4, 2016: Progress in Neuro-psychopharmacology & Biological Psychiatry
Sira Díaz-Morán, Marta Palència, Carme Mont-Cardona, Toni Cañete, Gloria Blázquez, Esther Martínez-Membrives, Regina López-Aumatell, Marta Sabariego, Rocío Donaire, Ignacio Morón, Carmen Torres, José Antonio Martínez-Conejero, Adolf Tobeña, Francisco José Esteban, Alberto Fernández-Teruel
To identify genes involved in the development/expression of anxiety/fear, we analyzed the gene expression profile in the hippocampus of genetically heterogeneous NIH-HS rats. The NIH-HS rat stock is a unique genetic resource for the fine mapping of quantitative trait loci (QTLs) to very small genomic regions, due to the high amount of genetic recombinants accumulated along more than 50 breeding generations, and for the same reason it can be expected that those genetically heterogeneous rats should be especially useful for studying differential gene expression as a function of anxiety, fearfulness or other complex traits...
November 15, 2013: Behavioural Brain Research
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