Sira Díaz-Morán, Marta Palència, Carme Mont-Cardona, Toni Cañete, Gloria Blázquez, Esther Martínez-Membrives, Regina López-Aumatell, Marta Sabariego, Rocío Donaire, Ignacio Morón, Carmen Torres, José Antonio Martínez-Conejero, Adolf Tobeña, Francisco José Esteban, Alberto Fernández-Teruel
To identify genes involved in the development/expression of anxiety/fear, we analyzed the gene expression profile in the hippocampus of genetically heterogeneous NIH-HS rats. The NIH-HS rat stock is a unique genetic resource for the fine mapping of quantitative trait loci (QTLs) to very small genomic regions, due to the high amount of genetic recombinants accumulated along more than 50 breeding generations, and for the same reason it can be expected that those genetically heterogeneous rats should be especially useful for studying differential gene expression as a function of anxiety, fearfulness or other complex traits...
November 15, 2013: Behavioural Brain Research