keyword
https://read.qxmd.com/read/38501821/fatty-acids-of-helicobacter-pylori-lipoproteins-cagt-and-lpp20
#21
JOURNAL ARTICLE
Mark S McClain, William E Boeglin, Holly M Scott Algood, Alan R Brash
Bacterial lipoproteins are post-translationally modified by the addition of acyl chains that anchor the protein to bacterial membranes. This modification includes two ester-linked and one amide-linked acyl chain on lipoproteins from Gram-negative bacteria. Helicobacter pylori lipoproteins have important functions in pathogenesis (including delivering the CagA oncoprotein to mammalian cells) and are recognized by host innate and adaptive immune systems. The number and variety of acyl chains on lipoproteins impact the innate immune response through Toll-like receptor 2...
March 19, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38499886/severe-induction-of-aberrant-dna-methylation-by-nodular-gastritis-in-adults
#22
JOURNAL ARTICLE
Akiko Sasaki, Hideyuki Takeshima, Satoshi Yamashita, Chikamasa Ichita, Jun Kawachi, Wataru Naito, Yui Ohashi, Chihiro Takeuchi, Masahide Fukuda, Yumi Furuichi, Nobutake Yamamichi, Takayuki Ando, Hideki Kobara, Tohru Kotera, Takao Itoi, Chihiro Sumida, Akinobu Hamada, Kazuya Koizumi, Toshikazu Ushijima
BACKGROUND: Nodular gastritis (NG) is characterized by marked antral lymphoid follicle formation, and is a strong risk factor for diffuse-type gastric cancer in adults. However, it is unknown whether aberrant DNA methylation, which is induced by atrophic gastritis (AG) and is a risk for gastric cancer, is induced by NG. Here, we analyzed methylation induction by NG. METHODS: Gastric mucosal samples were obtained from non-cancerous antral tissues of 16 NG and 20 AG patients with gastric cancer and 5 NG and 6 AG patients without, all age- and gender-matched...
March 19, 2024: Journal of Gastroenterology
https://read.qxmd.com/read/38497573/research-progress-in-photodynamic-therapy-for-helicobacter-pylori-infection
#23
REVIEW
Qian Luo, Chunyan Liu, Aiping Zhang, Dekui Zhang
Helicobacter pylori (H. pylori) is a pathogenic microorganism that colonizes the human gastric mucosa and can lead to various gastric disorders, including gastritis, gastric ulcers, and gastric cancer. However, the increasing prevalence of antibiotic resistance in H. pylori has prompted the search for alternative treatment options. Photodynamic therapy has emerged as a potential alternative therapy, thus offering the advantage of avoiding some of the side effects associated with antibiotics and effectively targeting drug-resistant strains...
2024: Helicobacter
https://read.qxmd.com/read/38495972/the-role-of-probiotics-in-the-eradication-of-helicobacter-pylori-and-overall-impact-on-management-of-peptic-ulcer-a-study-involving-patients-undergoing-triple-therapy-in-bangladesh
#24
JOURNAL ARTICLE
Taslima Zaman, Ahsanul Haq, Rahnuma Ahmad, Susmita Sinha, Kona Chowdhury, Sultana Parvin, Mostofa Imran, Zaman U Humayra, Santosh Kumar, Mainul Haque
Background Helicobacter pylori infection has been identified to cause constantly recurring inflammation, leading to gastrointestinal tract disorders, including carcinoma. The standard triple therapy (STT), used to eradicate H. pylori, includes two antimicrobials and a proton pump inhibitor for two weeks. Other drug regimens have also been developed since H. pylori exhibits antimicrobial resistance. These regimens, including probiotics, have been shown to lower adverse drug reactions (ADR), improve drug adherence, exert bacteriostatic effect, and reduce inflammation...
March 2024: Curēus
https://read.qxmd.com/read/38485609/cancer-associated-snps-in-bacteria-lessons-from-helicobacter-pylori
#25
REVIEW
Bodo Linz, Heinrich Sticht, Nicole Tegtmeyer, Steffen Backert
Several single-nucleotide polymorphisms (SNPs) in human chromosomes are known to predispose to cancer. However, cancer-associated SNPs in bacterial pathogens were unknown until discovered in the stomach pathogen Helicobacter pylori. Those include an alanine-threonine polymorphism in the EPIYA-B phosphorylation motif of the injected effector protein CagA that affects cancer risk by modifying inflammatory responses and loss of host cell polarity. A serine-to-leucine change in serine protease HtrA is associated with boosted proteolytic cleavage of epithelial junction proteins and introduction of DNA double-strand breaks (DSBs) in host chromosomes, which co-operatively elicit malignant alterations...
March 13, 2024: Trends in Microbiology
https://read.qxmd.com/read/38484705/a-tough-act-to-swallow-streptococcusanginosus-and-gastric-cancer
#26
JOURNAL ARTICLE
Sunny Wong, Patrick Tan
Gastric cancer is a deadly global malignancy caused by Helicobacter pylori infection. In a recent issue of Cell, Fu et al. identify Streptococcus anginosus, a bacterium normally residing in the oral cavity, as an additional contributor to gastric carcinogenesis.
March 13, 2024: Cell Host & Microbe
https://read.qxmd.com/read/38483540/myricetin-induces-ferroptosis-and-inhibits-gastric-cancer-progression-by-targeting-nox4
#27
JOURNAL ARTICLE
Yi Lu, Jingguo Sun, Mingyue Yang, Yuanxin Xing, Wenshuai Zhu, Jingyu Zhu, Xiaoli Ma, Yunshan Wang, Lu Wang, Yanfei Jia
Ferroptosis holds great potential as a therapeutic approach for gastric cancer (GC), a prevalent and deadly malignant tumor associated with high rates of incidence and mortality. Myricetin, well-known for its multifaceted biomedical attributes, particularly its anticancer properties, has yet to be thoroughly investigated regarding its involvement in ferroptosis. The aim of this research was to elucidate the impact of myricetin on ferroptosis in GC progression. The present study observed that myricetin could trigger ferroptosis in GC cells by enhancing malondialdehyde production and Fe2+ accumulation while suppressing glutathione levels...
March 14, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38483354/helicobacter-pylori-infection-at-crossroads-between-specialties
#28
JOURNAL ARTICLE
Roxana Florentina Chivu, Florin Bobirca, Dan Dumitrescu, Cristina Alexandru, Traian Patrascu
Background: Helicobacter pylori (H. pylori) infection is one of the major current public health problems, its incidence being high worldwide. This condition is associated with other pathologies such as peptic ulcer or gastric cancer, causing a real challenge for specialists in the medical field. Methods: We conducted a retrospective study that includes a cohort of 275 patients who performed EGD and were tested for the presence of H. pylori by the stool antigen test, between July 2022 and December 2023. Results: The cohort had an average age of 62...
March 2024: Chirurgia
https://read.qxmd.com/read/38481347/stat3-mediated-up-regulation-of-dab2-via-src-yap1-signaling-axis-promotes-helicobacter-pylori-driven-gastric-tumorigenesis
#29
JOURNAL ARTICLE
Yantao Duan, Pengfei Kong, Mingzhu Huang, Yonghao Yan, Yi Dou, Binhao Huang, Jing Guo, Wei Kang, Caixia Zhu, Yuyan Wang, Donglei Zhou, Qiliang Cai, Dazhi Xu
BACKGROUND: Helicobacter pylori (H pylori) infection is the primary cause of gastric cancer (GC). The role of Disabled-2 (DAB2) in GC remains largely unclear. This study aimed to investigate the role of DAB2 in H pylori-mediated gastric tumorigenesis. METHODS: We screened various datasets of GC to analyze DAB2 expression and cell signaling pathways. DAB2 expression was assessed in human GC tissue microarrays. H pylori infection in vivo and in vitro models were further explored...
March 13, 2024: Biomarker Research
https://read.qxmd.com/read/38477847/high-antibiotic-resistance-rates-in-helicobacter-pylori-strains-in-turkey-over-20-years-implications-for-gastric-disease-treatment
#30
JOURNAL ARTICLE
Burak Sarikaya, Riza Aytaç Çetinkaya, Derya Özyiğitoğlu, Sinem Akkaya Işik, Mustafa Kaplan, Duygu Kirkik, Levent Görenek
OBJECTIVE: Helicobacter pylori (Hp) eradication therapy is crucial for preventing the development of gastritis, peptic ulcers, and gastric cancer. An increase in resistance against antibiotics used in the eradication of Hp is remarkable. This meta-analysis aims to examine the resistance rates of Hp strains isolated in Turkey over the last 20 years against clarithromycin (CLR), metronidazole (MTZ), levofloxacin (LVX), tetracycline (TET), and amoxicillin (AMX) antibiotics. BASIC METHODS: Literature search was carried out in electronic databases, by searching articles published in Turkish and English with the keywords 'helicobacter pylori' or 'Hp' and 'antibiotic resistance' and 'Turkey'...
March 11, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38477524/-cost-effectiveness-analysis-of-a-vaccine-for-helicobacter-pylori-in-southern-europe
#31
JOURNAL ARTICLE
José Vicente Arcos-Machancoses, Martín Romero Prada, Elena Crehuá Gaudiza, Cecilia Martínez Costa
OBJECTIVE: There is sufficient evidence on the feasibility of a vaccine to prevent Helicobacter pylori infection. Modeling studies in low prevalence environments report a very probable long-term cost-effectiveness. The objective of this study was to quantify its efficiency in a local context. METHODS: The evolution of a cohort of newborns was simulated through a compartmental model representing a series of clinical situations regarding H. pylori infection and related diseases...
March 4, 2024: Revista Española de Salud Pública
https://read.qxmd.com/read/38463926/association-between-muc1-rs4072037-polymorphism-and-helicobacter-pylori-in-patients-with-gastric-cancer
#32
JOURNAL ARTICLE
Ramin Shekarriz, Hadi Jabbari, Reza Alikhani, Reza Alizadeh-Navaei, Mohammad Bagher Hashemi-Soteh
BACKGROUND: The MUC1 gene encodes glycoproteins attached to cell membrane that play a protective role in gastric cancer and protect epithelial surfaces against external factors such as Helicobacter pylori . H. pylori infection can induce a cascade of innate and acquired immune responses in gastric mucosa. Relationship between rs4072037G>A polymorphism of MUC1 gene and increased susceptibility to H. pylori infection aimed to investigate in patients with gastric cancer in Mazandaran, northern Iran...
2024: Caspian Journal of Internal Medicine
https://read.qxmd.com/read/38459689/volatilomic-signatures-of-different-strains-of-helicobacter-pylori
#33
JOURNAL ARTICLE
Reinis Vangravs, Linda Mežmale, Daria Ślefarska-Wolak, Edgars Dauss, Clemens Ager, Alejandro H Corvalan, Elmer Andrés Fernández, Chris A Mayhew, Marcis Leja, Paweł Mochalski
BACKGROUND: Helicobacter pylori (H. pylori) infection is the most extensively studied risk factor for gastric cancer. As with any bacteria, H. pylori will release distinctive odors that result from an emission of volatile metabolic byproducts in unique combinations and proportions. Effectively capturing and identifying these volatiles can pave the way for the development of innovative and non-invasive diagnostic methods for determining infection. Here we characterize the H. pylori volatilomic signature, pinpoint potential biomarkers of its presence, and evaluate the variability of volatilomic signatures between different H...
2024: Helicobacter
https://read.qxmd.com/read/38453620/pires2-egfp-ctb-urei-vaccination-activated-a-mixed-th1-th2-th17-immune-system-defense-towards-helicobacter-pylori-infection-in-the-balb-c-mice-model
#34
JOURNAL ARTICLE
Sana Ghasemifar, Omid Chabak, Tohid Piri-Gharaghie, Abbas Doosti
The occurrence of gastritis, gastric ulcers, distal gastric cancer, and gastric mucosal lymphoma in humans is strongly associated with Helicobacter pylori (H. pylori). Vaccination is an effective preventive measure due to the increasing prevalence of antibiotic resistance. Fusion vaccination is a potentially practical approach. A fusion vaccine was created in this study by combining the cholera toxin B subunit (CTB) with the antigenic H. pylori urease I subunit (CTB-UreI). The CTB-UreI DNA vaccine was chemically cloned into pIRES2-EGFP, and the success of the cloning was validated using PCR and restriction enzyme digestion...
March 7, 2024: Vaccine
https://read.qxmd.com/read/38453048/a-comparative-analysis-of-univariate-versus-multivariate-eco-friendly-spectrophotometric-manipulations-for-resolving-severely-overlapped-spectra-of-vonoprazan-and-amoxicillin-new-combination
#35
JOURNAL ARTICLE
Ahmed K Kammoun, Hani M Hafez, Ebraam B Kamel, Michael Gamal Fawzy
Vonoprazan and amoxicillin are pharmacological combinations that demonstrate synergistic effects in treating Helicobacter pylori (H. pylori), a global public health concern associated with peptic ulcer disease and gastric cancer. Four spectrophotometric methods were developed, including two univariate techniques (Fourier self-deconvolution and ratio difference) and two multivariate chemometric approaches (partial least squares and principal component regression). These methods provide innovative solutions for effectively resolving and accurately quantifying the overlapping spectra of Vonoprazan and amoxicillin...
March 5, 2024: Analytical Biochemistry
https://read.qxmd.com/read/38451664/helicobacter-pylori-oipa-virulence-gene-as-a-molecular-marker-of-severe-gastropathies
#36
JOURNAL ARTICLE
Diogo Nery Maciel, Lucas Luiz de Lima Silva, Leandro do Prado Assunção, Lucas Trevizani Rasmussen, Mônica Santiago Barbosa
BACKGROUND: Helicobacter pylori is an etiologic agent of gastroduodenal diseases. The microorganism, considered a type I carcinogen, affects about 50% of the global population. H. pylori virulence factors are determinant for the clinical outcome of the infection. The outer inflammatory protein A (oipA) gene encodes an outer membrane adhesin and is related to severe gastropathies, such as gastric cancer. OBJECTIVE: The aim of this study was to evaluate the association of the oipA gene with the severity of gastroduodenal diseases in dyspeptic patients in region Central Brazil...
2024: Arquivos de Gastroenterologia
https://read.qxmd.com/read/38447558/h-pylori-infection-a-40-year-journey-through-shifting-the-paradigm-to-transforming-the-management
#37
REVIEW
Peter Malfertheiner, Christian Schulz, Richard H Hunt
Background Helicobacter pylori (H.pylori) was discovered 40 years ago and has set a milestone in human medicine. The discovery led to rejection of the dogma of the acidic stomach as a sterile organ and requested to rewrite the chapters on gastric pathophysiology and gastroduodenal diseases . Summary Over a period of 40 years following the discovery ,more than 50.000 articles can be retrieved in Pubmed as of today and illustrate the amount and the intensity of research around the role of this bacterium. H.pylori emerged as cause of chronic gastritis and principal cause of peptic ulcer disease (PUD)...
March 6, 2024: Digestive Diseases
https://read.qxmd.com/read/38444677/retrospective-cohort-study-investigating-association-between-precancerous-gastric-lesions-and-colorectal-neoplasm-risk
#38
JOURNAL ARTICLE
Hui Pan, Yu-Long Zhang, Chao-Ying Fang, Yu-Dai Chen, Li-Ping He, Xiao-Ling Zheng, Xiaowen Li
BACKGROUND: Colorectal cancer (CRC) is considered the most prevalent synchronous malignancy in patients with gastric cancer. This large retrospective study aims to clarify correlations between gastric histopathology stages and risks of specific colorectal neoplasms, to optimize screening and reduce preventable CRC. METHODS: Clinical data of 36,708 patients undergoing gastroscopy and colonoscopy from 2005-2022 were retrospectively analyzed. Correlations between gastric and colorectal histopathology were assessed by multivariate analysis...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38443332/disruption-of-the-gastric-epithelial-barrier-in-correa-s-cascade-clinical-evidence-via-confocal-endomicroscopy
#39
JOURNAL ARTICLE
Shao-Tong Wang, Hua-Wei Yang, Wen-Lin Zhang, Zhen Li, Rui Ji
BACKGROUND: Gastric epithelial barrier disruption constitutes a crucial step in gastric cancer (GC). We investigated these disruptions during the Correa's cascade timeline to correlate epithelial barrier dysfunction. MATERIALS AND METHODS: This study was conducted as a single-center, non-randomized clinical trial in China from May 2019 to October 2022. Patients with chronic atrophic gastritis (CAG), gastric intestinal metaplasia (GIM), low-grade intraepithelial neoplasia (LGIN), high-grade intraepithelial neoplasia (HGIN), and intramucosal carcinoma underwent probe-based confocal laser endomicroscopy (pCLE)...
2024: Helicobacter
https://read.qxmd.com/read/38440419/predictive-factors-associated-with-survival-in-female-gastric-cancer-patients-in-southeast-asia
#40
JOURNAL ARTICLE
Phubordee Bongkotvirawan, Natsuda Aumpan, Bubpha Pornthisarn, Soonthorn Chonprasertsuk, Sith Siramolpiwat, Patommatat Bhanthumkomol, Pongjarat Nunanun, Navapan Issariyakulkarn, Varocha Mahachai, Kammal Kumar Pawa, Ratha-Korn Vilaichone
INTRODUCTION: Association of Southeast Asian Nations (ASEAN) countries have high Helicobacter pylori infections, and gastric cancer (GC) is a leading fatal cancer in this region, especially in female patients. This study aimed to compare clinical manifestations, histopathological subtypes, and prognostic factors associated with the overall survival rate of female GC patients in this important region. METHODS: This retrospective cohort study was conducted between 2007 and 2022 at a tertiary care center in Thailand...
2024: Women's health reports
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