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Helicobacter and gastric cancer

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https://www.readbyqxmd.com/read/29345408/the-effect-of-eradication-of-helicobacter-pylori-on-gastric-cancer-prevention-in-healthy-asymptomatic-populations
#1
Suh Eun Bae, Kee Don Choi, Jaewon Choe, Seon Ok Kim, Hee Kyong Na, Ji Young Choi, Ji Yong Ahn, Kee Wook Jung, JeongHoon Lee, Do Hoon Kim, Hye-Sook Chang, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
BACKGROUND: Although many epidemiologic studies have evaluated the effect of Helicobacter pylori eradication on gastric cancer, the effect is still uncertain in general populations. We evaluated whether H. pylori eradication would affect the incidence of gastric cancer in healthy asymptomatic populations. MATERIALS AND METHODS: We performed a retrospective cohort study in 38 984 asymptomatic individuals, who underwent health screening examinations more than twice between 2005 and 2016...
January 18, 2018: Helicobacter
https://www.readbyqxmd.com/read/29334503/family-history-of-autoimmune-diseases-and-risk-of-gastric-cancer-a-national-cohort-study
#2
Jianguang Ji, Jan Sundquist, Kristina Sundquist
A personal history of autoimmune diseases is associated with an increased incidence of gastric cancer, but whether they share familial susceptibility is still unknown. The contribution of shared environmental or genetic factors toward the observed familial aggregation has not been determined. We used a few Swedish registers, including the Swedish Multigeneration Register and the Cancer Register, to examine the familial risk of gastric cancer among individuals with a family history of a set of autoimmune diseases...
January 12, 2018: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29333062/helicobacter-pylori-infection-and-esophageal-adenocarcinoma-a-review-and-a-personal-view
#3
REVIEW
Stergios A Polyzos, Christos Zeglinas, Fotini Artemaki, Michael Doulberis, Evangelos Kazakos, Panagiotis Katsinelos, Jannis Kountouras
Esophageal adenocarcinoma (EAC) is etiologically associated with gastroesophageal reflux disease (GERD). There is evidence to support the sequence GERD, Barrett's esophagus (BE), dysplasia, and finally EAC, with Helicobacter pylori (H. pylori) being implicated in each step to EAC. On the other side of this relation stands the hypothesis of the protective role of H. pylori against EAC. Based on this controversy, our aim was to review the literature, specifically original clinical studies and meta-analyses linking H...
January 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29329668/helicobacter-pylori-induces-direct-activation-of-the-lymphotoxin-beta-receptor-and-non-canonical-nuclear-factor-kappa-b-signaling
#4
Michael Hartmut Feige, Michael Vieth, Olga Sokolova, Christian Täger, Michael Naumann
The pathogen Helicobacter pylori, which infects half of the world's population, is a major risk factor for the development of gastric diseases including chronic gastritis and gastric cancer. Among H. pylori's virulence factors is the cytotoxin-associated gene pathogenicity island (cagPAI), which encodes for a type IV secretion system (T4SS). The T4SS induces fast canonical nuclear factor-kappa B (NF-κB) signaling, a major factor increasing inflammation, supressing apoptotic cell death and thereby promoting the development of neoplasia...
January 9, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29322413/isolation-of-mouse-primary-gastric-epithelial-cells-to-investigate-the-mechanisms-of-helicobacter-pylori-associated-disease
#5
Le Son Tran, Richard L Ferrero
The gastrointestinal epithelium provides the first line of defense against invading pathogens, among which Helicobacter pylori is linked to numerous gastric pathologies, including chronic gastritis and cancer. Primary gastric epithelial cells represent a useful model for the investigation of the underlying molecular and cellular mechanisms involved in these H. pylori associated diseases. In this chapter, we describe a method for the isolation of primary gastric epithelial cells from mice and detection of epithelial cell adhesion molecule (EpCAM) expression in the isolated cells...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29319212/synergistic-glycosylation-as-key-to-the-chemical-synthesis-of-an-outer-core-octasaccharide-of-helicobacter-pylori
#6
Jian Yin, Xiaopeng Zou, Chunjun Qin, Claney L Pereira, Guangzong Tian, Jing Hu, Peter H Seeberger
Helicobacter pylori, a widespread gastric bacterial pathogen that infects 90% of the population in developing countries, causes chronic gastritis, peptic ulcers and gastric cancer. Battling H. pylori infection is a serious challenge due to the increased resistance to antibiotics and the lack of vaccines. The lipopolysaccharide covering the H. pylori cell-surface outer membrane is an attractive target for the development of a glycoconjugate vaccine. Here, we report a [3+5] convergent synthesis of an outer core octasaccharide of H...
January 10, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29317709/increased-abundance-of-clostridium-and-fusobacterium-in-gastric-microbiota-of-patients-with-gastric-cancer-in-taiwan
#7
Yung-Yu Hsieh, Shui-Yi Tung, Hung-Yu Pan, Chih-Wei Yen, Huang-Wei Xu, Ying-Jhen Lin, Yi-Fang Deng, Wan-Ting Hsu, Cheng-Shyong Wu, Chin Li
Helicobacter pylori is recognised as a main risk factor for gastric cancer. However, approximately half of the patients with gastritis are negative for H. pylori infection, and the abundance of H. pylori decreases in patients with cancer. In the current study, we profiled gastric epithelium-associated bacterial species in patients with gastritis, intestinal metaplasia, and gastric cancer to identify additional potential pathogenic bacteria. The overall composition of the microbiota was similar between the patients with gastritis and those with intestinal metaplasia...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29317648/nf-%C3%AE%C2%BAb-mir-223-3p-arid1a-axis-is-involved-in-helicobacter-pylori-caga-induced-gastric-carcinogenesis-and-progression
#8
Fenghua Yang, Yugang Xu, Chao Liu, Cunying Ma, Shuiyan Zou, Xia Xu, Jihui Jia, Zhifang Liu
Infection with Helicobacter pylori (H. pylori) and the resulting gastric inflammation is regarded as the strongest risk factor for gastric carcinogenesis and progression. NF-κB plays an important role in linking H. pylori-mediated inflammation to cancer. However, the underlying mechanisms are poorly understood. In this study, we find that H. pylori infection induces miR-223-3p expression in H. pylori CagA-dependent manner. NF-κB stimulates miR-223-3p expression via directly binding to the promoter of miR-223-3p and is required for H...
January 9, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29316052/an-assessment-of-drinking-water-contamination-with-helicobacter-pylori-in-lima-peru
#9
Kevin F Boehnke, Rebecca K Brewster, Brisa N Sánchez, Manuel Valdivieso, Alejandro Bussalleu, Magaly Guevara, Claudia Gonzales Saenz, Soledad Osorio Alva, Elena Gil, Chuanwu Xi
BACKGROUND: Helicobacter pylori is a gut bacterium that is the primary cause of gastric cancer. H. pylori infection has been consistently associated with lack of access to sanitation and clean drinking water. In this study, we conducted time-series sampling of drinking water in Lima, Peru, to examine trends of H. pylori contamination and other water characteristics. MATERIALS AND METHODS: Drinking water samples were collected from a single faucet in Lima's Lince district 5 days per week from June 2015 to May 2016, and pH, temperature, free available chlorine, and conductivity were measured...
January 8, 2018: Helicobacter
https://www.readbyqxmd.com/read/29315971/levels-of-malondialdehyde-in-the-gastric-juice-its-association-with-helicobacter-pylori-infection-and-stomach-diseases
#10
Yao-Kuang Wang, Wei-Chih Chiang, Fu-Chen Kuo, Meng-Chieh Wu, Hsiang-Yao Shih, Sophie S W Wang, Chung-Jung Liu, Yen-Hsu Chen, Deng-Chyang Wu, Wei-Wen Su, Yeou-Lih Huang
BACKGROUND: Helicobacter pylori (H. pylori) infection causes elevation of lipid peroxidation product malondialdehyde (MDA) and this association may be due to the bacterium causing reactive oxygen species-mediated damage to DNA in the gastric epithelium. The aim of this study was to investigate the gastric juice MDA levels in relation to H. pylori infection and associated gastric diseases. METHODS: Gastric juice samples were obtained from 117 patients undergoing endoscopy, and gastric juice MDA levels were determined by high-performance liquid chromatography (HPLC) system...
January 5, 2018: Helicobacter
https://www.readbyqxmd.com/read/29312558/hyperglycemia-combined-helicobacter-pylori-infection-increases-risk-of-synchronous-colorectal-adenoma-and-carotid-artery-plaque
#11
Kuang-Chun Hu, Ming-Shiang Wu, Cheng-Hsin Chu, Horng-Yuan Wang, Shee-Chan Lin, Helen L Po, Ming-Jong Bair, Chuan-Chuan Liu, Tung-Hung Su, Chi-Ling Chen, Chun-Jen Liu, Shou-Chuan Shih
Background: Cardiovascular disease and colorectal cancer have severe consequences to human health and may occur simultaneously or sequentially. Carotid artery plaque is a predictor of cardiovascular disease, and colorectal adenoma is a premalignant lesion of colorectal cancer. We investigated the core risk factors of carotid artery plaque and colorectal adenoma. Results: In total, 2361 subjects were enrolled. In multivariate analysis, age ≥ 60 years, male sex, BMI > 27, LDL > 130 mg/dL, HbA1c ≥ 6...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29306868/gastritis-staging-in-the-endoscopic-follow-up-for-the-secondary-prevention-of-gastric-cancer-a-5-year-prospective-study-of-1755-patients
#12
Massimo Rugge, Alberto Meggio, Cecilia Pravadelli, Mattia Barbareschi, Matteo Fassan, Maria Gentilini, Manuel Zorzi, Giovanni De Pretis, David Y Graham, Robert M Genta
OBJECTIVE: Operative link on gastritis assessment (OLGA) staging for gastritis ranks the risk for gastric cancer (GC) in progressive stages (0-IV). This prospective study aimed at quantifying the cancer risk associated with each gastritis stage. DESIGN: A cohort of 1755 consecutive patients with dyspepsia underwent initial (T-0) oesophagogastroduodenoscopy with mapped gastric biopsies, OLGA staging and assessment of Helicobacter pylori infection. Patients were followed for 55 months (median); patients with stages II III and IV underwent a second endoscopy/restaging (T-1), and those with stages 0 and I were followed clinically and through in-depth clinical and record checking...
January 6, 2018: Gut
https://www.readbyqxmd.com/read/29303193/nanoparticle-binding-attenuates-the-pathobiology-of-gastric-cancer-associated-helicobacter-pylori
#13
Dana Westmeier, Gernot Posselt, Angelina Hahlbrock, Sina Bartfeld, Cecilia Vallet, Carmen Abfalter, Dominic Docter, Shirley K Knauer, Silja Wessler, Roland H Stauber
Enteric bacteria may cause severe diseases, including gastric cancer-associated Helicobacter pylori. Their infection paths overlap with the oro-gastrointestinal uptake route for nanoparticles, increasingly occurring during environmental or consumer/medical exposure. By comprehensive independent analytical methods, such as live cell fluorescence, electron as well as atomic force microscopy and elemental analysis, we show that a wide array of nanoparticles (NPs) but not microparticles form complexes with H. pylori and enteric pathogens without the need for specific functionalization...
January 5, 2018: Nanoscale
https://www.readbyqxmd.com/read/29302146/helicobacter-pylori-in-dyspepsia-phenotypic-and-genotypic-methods-of-diagnosis
#14
Vignesh Shetty, Mamatha Ballal, Girisha Balaraju, Shiran Shetty, Ganesh C Pai, Ramachandra Lingadakai
Background: Helicobacter pylori affects almost half of the world's population and therefore is one of the most frequent and persistent bacterial infections worldwide. H. pylori is associated with chronic gastritis, ulcer disease (gastric and duodenal), mucosa-associated lymphoid tissue lymphoma, and gastric cancer. Several diagnostic methods exist to detect infection and the option of one method or another depends on various genes, such as availability, advantages and disadvantages of each method, monetary value, and the age of patients...
October 2017: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/29290541/genomic-and-epigenomic-profiling-of-high-risk-intestinal-metaplasia-reveals-molecular-determinants-of-progression-to-gastric-cancer
#15
Kie Kyon Huang, Kalpana Ramnarayanan, Feng Zhu, Supriya Srivastava, Chang Xu, Angie Lay Keng Tan, Minghui Lee, Suting Tay, Kakoli Das, Manjie Xing, Aliya Fatehullah, Syed Muhammad Fahmy Alkaff, Tony Kiat Hon Lim, Jonathan Lee, Khek Yu Ho, Steven George Rozen, Bin Tean Teh, Nick Barker, Chung King Chia, Christopher Khor, Choon Jin Ooi, Kwong Ming Fock, Jimmy So, Wee Chian Lim, Khoon Lin Ling, Tiing Leong Ang, Andrew Wong, Jaideepraj Rao, Andrea Rajnakova, Lee Guan Lim, Wai Ming Yap, Ming Teh, Khay Guan Yeoh, Patrick Tan
Intestinal metaplasia (IM) is a pre-malignant condition of the gastric mucosa associated with increased gastric cancer (GC) risk. We performed (epi)genomic profiling of 138 IMs from 148 cancer-free patients, recruited through a 10-year prospective study. Compared with GCs, IMs exhibit low mutational burdens, recurrent mutations in certain tumor suppressors (FBXW7) but not others (TP53, ARID1A), chromosome 8q amplification, and shortened telomeres. Sequencing identified more IM patients with active Helicobacter pylori infection compared with histopathology (11%-27%)...
December 26, 2017: Cancer Cell
https://www.readbyqxmd.com/read/29286091/identifying-heterogeneous-subtypes-of-gastric-cancer-and-subtype%C3%A2-specific-subpaths-of-microrna%C3%A2-target-pathways
#16
Yuanhang Li, Weijun Bai, Xu Zhang
The present study aimed to classify gastric cancer (GC) into subtypes and to screen the subtype‑specific genes, their targeted microRNAs (miRNAs) and enriched pathways to explore the putative mechanism of each GC subtypes. The GSE13861 data set was downloaded from the Gene Expression Omnibus and used to screen differential expression genes (DEGs) in GC samples based on the detection of imbalanced differential signal algorithm. The specific genes in each subtype were identified with the cut‑off criterion of U>0...
December 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29279585/distribution-of-gastric-adenocarcinoma-subtypes-in-different-ethnicities-in-kuala-lumpur-malaysia
#17
A Sukri, A Hanafiah, N R Kosai, M M Taher, I Mohamed Rose
The multiracial population in Malaysia has lived together for almost a century, however, the risk of gastric cancer among them varies. This study aimed to determine the distribution of different gastric adenocarcinoma subtypes and Helicobacter pylori infection status among gastric adenocarcinoma patients. Patients with gastric adenocarcinoma were enrolled from November 2013 to June 2015. Blood samples were collected for detection of H. pylori using ELISA method. Gastric adenocarcinoma cases were more prevalent in the Chinese (52...
December 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29273641/long-term-proton-pump-inhibitor-use-is-a-risk-factor-of-gastric-cancer-after-treatment-for-helicobacter-pylori-a-retrospective-cohort-analysis
#18
Ryota Niikura, Yoku Hayakawa, Yoshihiro Hirata, Atsuo Yamada, Mitsuhiro Fujishiro, Kazuhiko Koike
No abstract text is available yet for this article.
December 22, 2017: Gut
https://www.readbyqxmd.com/read/29251014/amaranth-oil-reduces-accumulation-of-4-hydroxynonenal-histidine-adducts-in-gastric-mucosa-and-improves-heart-rate-variability-in-duodenal-peptic-ulcer-patients-undergoing-helicobacter-pylori-eradication
#19
Andriy Cherkas, Kamelija Zarkovic, Ana Čipak, Morana Jaganjac, Lidija Milković, Orest Abrahamovych, Ostap Yatskevych, Georg Waeg, Olha Yelisyeyeva, Neven Zarkovic
Helicobacter pylori-induced oxidative stress in gastric mucosa (GM) is a milieu for the development of chronic gastritis, duodenal peptic ulcer (DPU), gastric cancer and a number of extragastric diseases. Because our previous study revealed the accumulation of the protein adducts of lipid peroxidation product 4-hydroxynonenal (HNE) in GM, which persists after eradication of H. pylori, the aim of the study was to test whether Amaranth oil supplementation in addition to standard anti-Helicobacter treatment could prevent such accumulation of HNE in GM in H...
December 17, 2017: Free Radical Research
https://www.readbyqxmd.com/read/29250766/expression-of-mirna-146a-mirna-155-il-2-and-tnf-%C3%AE-in-inflammatory-response-to-helicobacter-pylori-infection-associated-with-cancer-progression
#20
Luanna Munhoz Zabaglia, Mayara Luciana Sallas, Mônica Pezenatto Dos Santos, Wilson Aparecido Orcini, Rita Luiza Peruquetti, Dulce Helena Constantino, Elizabeth Chen, Marilia De Arruda Cardoso Smith, Spencer-Luiz Marques Payão, Lucas Trevizani Rasmussen
miRNAs appear to play an important role in controlling the expression of several genes, and they are a potential biomarker and prognostic tool in gastric diseases. We analyzed 53 controls, 86 patients with gastritis, and 19 patients with gastric cancer. Real-time-PCR was used to determine the expression levels of miRNA-146a, miRNA-155, IL-2, and TNF-α. The subsequent analysis of the target genes was performed using the bioinformatics approach. There was no difference in IL-2 expression between the groups. However, there was a significant increase in TNF-α expression in the gastritis group relative to the control and a significant decrease in the gastric cancer group relative to the control...
December 18, 2017: Annals of Human Genetics
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