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Helicobacter and gastric cancer

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https://www.readbyqxmd.com/read/27930268/recombinant-bacillus-subtilis-spores-expressing-cholera-toxin-b-subunit-and-helicobacter-pylori-urease-b-confers-protection-against-h-pylori-in-mice
#1
Zhenwen Zhou, Hui Dong, Shuwen Yao, Yanmei Huang, Bingshao Liang, Yongqiang Xie, Yan Long, Jialiang Mai, Sitang Gong
Helicobacter pylori infection is associated with chronic gastritis, peptic ulcers, gastric cancer and mucosa-associated lymphoid tissue lymphoma. The limitations of current therapies for Helicobacter pylori infection include poor compliance and antibiotic resistance. Therefore, an effective anti-H. pylori vaccine would be an alternative or complement to antibiotic treatment. Urease B (UreB) is considered an ideal vaccine antigen against H. pylori infection. In this study, cholera toxin B subunit (CTB), a mucosal adjuvant, was used to enhance the immunogenicity of novel Bacillus subtilis spores vaccine that express CTB-UreB along with the B...
December 8, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27923651/a-cheap-simple-high-throughput-method-for-screening-native-helicobacter-pylori-urease-inhibitors-using-a-recombinant-escherichia-coli-its-validation-and-demonstration-of-pistacia-atlantica-methanolic-extract-effectivity-and-specificity
#2
Natalie Amar, Avi Peretz, Yoram Gerchman
Helicobacter pylori is the most frequent and persistent bacterial infection worldwide, and a risk factor for active gastritis, peptic ulcers, mucosa-associated lymphoid tissue lymphoma, and gastric cancer. Although combined antibiotics treatment is effective cases of antibiotic resistance are reported at an alarming rate. The H. pylori urease enzyme is essential for the bacteria establishment in the gastric mucosa, resulting urease inhibitors being sought after as effective and specific anti- H. pylori treatment...
December 3, 2016: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/27921009/adhesion-and-invasion-of-gastric-mucosa-epithelial-cells-by-helicobacter-pylori
#3
REVIEW
Ying Huang, Qi-Long Wang, Dan-Dan Cheng, Wen-Ting Xu, Nong-Hua Lu
Helicobacter pylori is the main pathogenic bacterium involved in chronic gastritis and peptic ulcer and a class 1 carcinogen in gastric cancer. Current research focuses on the pathogenicity of H. pylori and the mechanism by which it colonizes the gastric mucosa. An increasing number of in vivo and in vitro studies demonstrate that H. pylori can invade and proliferate in epithelial cells, suggesting that this process might play an important role in disease induction, immune escape and chronic infection. Therefore, to explore the process and mechanism of adhesion and invasion of gastric mucosa epithelial cells by H...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27917621/association-of-nucleotide-binding-oligomerization-domain-receptors-with-peptic-ulcer-and-gastric-cancer
#4
Rajeeh Mohammadian Amiri, Mohsen Tehrani, Shirin Taghizadeh, Javad Shokri-Shirvani, Hafez Fakheri, Abolghasem Ajami
Host innate immunity can affect the clinical outcomes of Helicobacter pylori infection, including gastritis, gastric ulcer, gastric adenocarcinoma, and MALT lymphoma. Nucleotide binding oligomerization domain (NOD)-1 and -2 are two molecules of innate immunity which are involved in the host defense against H. pylori. This study aimed to evaluate the effect of the expression level of NOD1 and NOD2 on the susceptibility to gastric cancer as well as peptic ulcer in individuals with H. pylori infection. The gene expression levels of these molecules were compared in three groups of non-ulcer dyspepsia (NUD) as a control group (n=52); peptic ulcer disease (PUD), (n=53); and gastric cancer (GC), (n=39)...
October 2016: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/27916772/slow-progression-of-gastric-adenocarcinoma-of-fundic-gland-type-a-case-report
#5
Chiaki Kusumoto, Kenji Shigehara, Susumu Take, Kuniharu Ishiki, Kouhei Taniguchi
Here we report the case of a 73-year-old male who had undergone esophagogastroduodenoscopy (EGD) at a nearby hospital or at our hospital every year since 2006. In 2013, EGD results revealed a discolored lesion, measuring 6mm in diameter, on the anterior side of the upper body in the stomach. Helicobacter pylori (HP) was eradicated in 2010, and the background mucosa around the lesion was endoscopically diagnosed as non-atrophic. We performed endoscopic biopsy of the lesion. Histological examination of the specimen confirmed gastric adenocarcinoma of the fundic gland type...
2016: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/27914159/-molecular-mechanisms-for-adhesion-and-colonization-of-human-gastric-mucosa-by-helicobacter-pylori-and-its-clinical-implications
#6
REVIEW
Elisabete Coelho, Ana Magalhães, Mário Dinis-Ribeiro, Celso A Reis
INTRODUCTION: Helicobacter pylori infection is very prevalent worldwide and is associated with the progression of the gastric carcinogenesis cascade, being one of the main risk factors for the development of gastric carcinoma. Several factors are determinant for the infection and for the development of gastric disease, including environmental factors, host genetic factors and virulence factors of the bacteria. MATERIAL AND METHODS: In this review, we present an overview of the current knowledge on the determinants of the infection and on the recently described molecular mechanisms of Helicobacter pylori adhesion to the gastric mucosa, as well as its possible future therapeutic application...
August 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/27903713/-trained-immunity-consequences-for-lymphoid-malignancies
#7
REVIEW
Wendy B C Stevens, Mihai G Netea, Arnon P Kater, Walter J F M van der Velden
In hematological malignancies complex interactions exist between the immune system, microorganisms and malignant cells. On one hand, microorganisms can induce cancer, as illustrated by specific infection-induced lymphoproliferative diseases such as Helicobacter pylori-associated gastric mucosa-associated lymphoid tissue lymphoma. On the other hand, malignant cells create an immunosuppressive environment for their own benefit, but this also results in an increased risk of infections. Disrupted innate immunity contributes to the neoplastic transformation of blood cells by several mechanisms, including the uncontrolled clearance of microbial and autoantigens resulting in chronic immune stimulation and proliferation, chronic inflammation, and defective immune surveillance and anti-cancer immunity...
December 2016: Haematologica
https://www.readbyqxmd.com/read/27895737/high-parp-1-expression-is-associated-with-tumor-invasion-and-poor-prognosis-in-gastric-cancer
#8
Ying Liu, Yu Zhang, Ying Zhao, Dongna Gao, Jing Xing, Hui Liu
Poly (adenosine diphosphate-ribose) polymerase 1 (PARP-1) was previously demonstrated to be overexpressed in numerous malignant tumors and associated with invasiveness and poor prognosis. However, the expression of the PARP-1 protein in gastric cancer and its association with clinical outcomes requires further investigation. In the present study, the expression of PARP-1 in 564 gastric cancer tissues and 335 tumor-adjacent control tissues is investigated, using tissue microarray-based immunohistochemistry. PARP-1 expression levels were demonstrated to be significantly higher in gastric cancer tissue samples, as compared with control tissue samples...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27895391/characteristics-of-gastric-cancer-detected-within-1-year-after-successful-eradication-of-helicobacter-pylori
#9
Toshihiro Nishizawa, Hidekazu Suzuki, Toru Arano, Shuntaro Yoshida, Hiroharu Yamashita, Keisuke Hata, Takanori Kanai, Naohisa Yahagi, Osamu Toyoshima
Gastric cancers are sometimes diagnosed in patients who have successfully undergone Helicobacter pylori (H. pylori) eradication. We analyzed the clinicopathological features of gastric cancers detected after eradication to clarify their characteristics. We reviewed 31 patients with 34 cases of gastric cancer detected after successful H. pylori eradication. Clinicopathological characteristics analyzed included interval since eradication, interval since last endoscopy, tumor size, and depth of invasion. Patients were classified into two groups: early detection (<1 year since eradication) and delayed detection (≥1 year since eradication)...
November 2016: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/27891343/expression-of-alpha-methylacyl-coa-racemase-amacr-in-gastric-adenocarcinoma-and-its-correlation-with-helicobacter-pylori-infection
#10
Yamini Jindal, Anshul Singh, Ravikant Kumar, Kachnar Varma, Vatsala Misra, Sri Prakash Misra, Manisha Dwivedi
INTRODUCTION: Gastric cancer develops in a multistep progression and is determined by genetic and environmental factors. Over-expression of Alpha Methylacyl CoA Racemase (AMACR) is useful in diagnosis of prostate cancer. There is plenty of genetic alteration that occurs in gastric adenocarcinoma. The present study was planned to determine if AMACR can be used as a diagnostic marker in gastric adenocarcinoma similar to prostate cancer. AIM: To study the expression of AMACR in gastric adenocarcinoma and correlate its expression with density of Helicobacter pylori...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27886029/prevalence-of-h-pylori-in-gastric-biopsy-specimen-in-the-southeastern-region-of-turkey
#11
Fulya Bayındır Bilman, Mehmet Özdemir, Birol Baysal, Muhammed Güzel Kurtoğlu
INTRODUCTION: Helicobacter pylori is a Gram-negative, microaerophilic bacterium that colonizes human gastric mucosa. Gastric ulcer, duodenal ulcer, chronic atrophic gastritis, mucosa-associated lymphoid tissue lymphoma, and stomach adenocarcinoma are associated with H. pylori as the etiological agent. Cytotoxin-associated gene A (cagA), which is one of the most important virulence factors of H. pylori, encodes a 120-145 kDa protein. The prevalence of cagA genes shows differences in H...
November 24, 2016: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/27871161/helicobacter-pylori-eradication-modulates-aberrant-cpg-island-hypermethylation-in-gastric-carcinogenesis
#12
Jeongmin Choi, Sang Gyun Kim, Byeong Gwan Kim, Seong Joon Koh, Ji Won Kim, Kook Lae Lee
Background/Aims: Helicobacter pylori infection induces aberrant DNA methylation in gastric mucosa. We evaluated the long-term effect of H. pylori eradication on promotor CpG island hypermethylation in gastric carcinogenesis. Methods: H. pylori-positive patients with gastric adenoma or early gastric cancer who underwent endoscopic resection were enrolled. According to H. pylori eradication after endoscopic resection, the participants were randomly assigned to H. pylori eradication or non-eradication group...
November 25, 2016: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/27869178/importance-of-the-c-terminal-histidine-residues-of-helicobacter-pylori-groes-for-toll-like-receptor-4-binding-and-interleukin-8-cytokine-production
#13
Haur Lee, Yu-Lin Su, Bo-Shih Huang, Feng-Tse Hsieh, Ya-Hui Chang, Shiou-Ru Tzeng, Chun-Hua Hsu, Po-Tsang Huang, Kuo-Long Lou, Yeng-Tseng Wang, Lu-Ping Chow
Helicobacter pylori infection is associated with the development of gastric and duodenal ulcers as well as gastric cancer. GroES of H. pylori (HpGroES) was previously identified as a gastric cancer-associated virulence factor. Our group showed that HpGroES induces interleukin-8 (IL-8) cytokine release via a Toll-like receptor 4 (TLR4)-dependent mechanism and domain B of the protein is crucial for interactions with TLR4. In the present study, we investigated the importance of the histidine residues in domain B...
November 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27866909/unsaturated-fatty-acid-synthesis-in-the-gastric-pathogen-helicobacter-pylori-proceeds-via-a-backtracking-mechanism
#14
Hongkai Bi, Lei Zhu, Jia Jia, Liping Zeng, John E Cronan
Helicobacter pylori is a Gram-negative bacterium that inhabits the upper gastrointestinal tract in humans, and the presence of this pathogen in the gut microbiome increases the risk of peptic ulcers and stomach cancer. H. pylori depends on unsaturated fatty acid (UFA) biosynthesis for maintaining membrane structure and function. Although some of the H. pylori enzymes involved in UFA biosynthesis are functionally homologous with the enzymes found in Escherichia coli, we show here that an enzyme HP0773, now annotated as FabX, uses an unprecedented backtracking mechanism to not only dehydrogenate decanoyl-acyl carrier protein (ACP) in a reaction that parallels that of acyl-CoA dehydrogenase, the first enzyme of the fatty acid β-oxidation cycle, but also isomerizes trans-2-decenoyl-ACP to cis-3-decenoyl-ACP, the key UFA synthetic intermediate...
November 16, 2016: Cell Chemical Biology
https://www.readbyqxmd.com/read/27866197/rs56288038-c-g-in-3-utr-of-irf-1-regulated-by-mir-502-5p-promotes-gastric-cancer-development
#15
Bo Wang, Huan Yang, Liqin Shen, Ji Wang, Wangyang Pu, Zhigang Chen, Xudong Shen, Jinxiang Fu, Zhixiang Zhuang
BACKGROUND/AIMS: Interferon regulatory factor 1 (IRF-1) has been shown to function as a transcriptional activator or repressor of a variety of target genes. However, its upstream, non-coding RNA-related regulatory capacity remains unknown. In this study, we focus on the miRNA-associated single nucleotide polymorphisms (SNPs) in the 3'untranslated region (UTR) of IRF-1 to further investigate the functional relationship and potential diagnostic value of the SNPs and miRNAs among Chinese gastric cancer (GC) patients...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27862371/helicobacter-pylori-infection-modulates-the-expression-of-mirnas-associated-with-dna-mismatch-repair-pathway
#16
Juliana C Santos, Mitsue T Brianti, Victor R Almeida, Manoela M Ortega, Wolfgang Fischer, Rainer Haas, Ander Matheu, Marcelo L Ribeiro
Genetic and epigenetic inactivation of DNA mismatch repair (MMR) genes might lead to modifications in cancer-related gene expression and cancer development. Recently, it has been shown that the infection by Helicobacter pylori (H. pylori), the major causative agent of gastric cancer, induces DNA damage and inhibits MMR DNA repair. Also, it has been reported that microRNAs (miRs) have an important role in regulating genomic stability and MMR DNA repair. Thus, the aim of this study was to identify miRs regulating MMR pathway in H...
November 15, 2016: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/27858920/clinical-risk-assessment-for-gastric-cancer-in-asymptomatic-population-after-a-health-check-up-an-individualized-consideration-of-the-risk-factors
#17
Yoo Mi Park, Jie-Hyun Kim, Su Jung Baik, Jae Jun Park, Young Hoon Youn, Hyojin Park
For the prevention of gastric cancer, the detection of risk factors associated with precancerous conditions may be more informative. The aim of this study was to identify the risk factors of gastric cancer, including precancerous conditions: atrophic gastritis (AG), intestinal metaplasia (IM), and dysplasia.The clinical and endoscopic findings of 60,261 adults who underwent gastroduodenoscopy as part of a health check-up were reviewed retrospectively. Subgroup analysis was conducted according to age, sex, cancer stage, and histology based on Lauren classification...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27853902/the-contribution-of-helicobacter-pylori-to-excess-gastric-cancer-in-indigenous-and-pacific-men-a-birth-cohort-estimate
#18
Andrea M Teng, Tony Blakely, Michael G Baker, Diana Sarfati
BACKGROUND: The reasons for higher gastric cancer incidence rates in indigenous populations are debated. METHODS: We quantify the role of Helicobacter pylori in excess gastric cancer incidence in Māori and Pacific men in New Zealand. Age-standardized gastric cancer rate ratios for 1981-2004 were calculated in Māori and Pacific men compared with European/other men born in 1926-1940 and in 1941-1955. Rate ratios were then compared with those restricted to H. pylori prevalent populations...
November 16, 2016: Gastric Cancer
https://www.readbyqxmd.com/read/27849173/imaging-the-motility-and-chemotaxis-machineries-in-helicobacter-pylori-by-cryo-electron-tomography
#19
Zhuan Qin, Wei-Ting Lin, Shiwei Zhu, Aime T Franco, Jun Liu
: Helicobacter pylori is a bacterial pathogen that can cause many gastrointestinal diseases including ulcers and gastric cancer. A unique chemotaxis-mediated motility is critical for H. pylori to colonize in the human stomach and to establish chronic infection, but the underlying molecular mechanisms are not well understood. Here we employ cryo-electron tomography to reveal detailed structures of the H. pylori cell envelope including the sheathed flagella and chemotaxis arrays. Notably, H...
November 14, 2016: Journal of Bacteriology
https://www.readbyqxmd.com/read/27835575/helicobacter-pylori-infection-related-long-noncoding-rna-lncrna-af147447-inhibits-gastric-cancer-proliferation-and-invasion-by-targeting-muc2-and-up-regulating-mir-34c
#20
Xiaoying Zhou, Han Chen, Li Zhu, Bo Hao, Weifeng Zhang, Jie Hua, Huiyuan Gu, Wujuan Jin, Guoxin Zhang
Long non-coding RNAs (lncRNAs) were shown to play critical roles in cancer biology. We investigated whether H. pylori infection could promote gastric cancer by regulating lncRNAs expression. Differentially expressed lncRNAs between H. pylori positive and negative tissues were identified by microarray and validated by qRT-PCR. Our results indicated that H. pylori positive tissues have a specific profile of lncRNAs. Cell biological assays with siRNA-mediated knockdown or lentivirus vector-mediated over-expression were performed to probe the functional relevance of the lncRNAs...
November 7, 2016: Oncotarget
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