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Helicobacter and gastric cancer

Yusuke Horiuchi, Junko Fujisaki, Noriko Yamamoto, Shoichi Yoshimizu, Akiyoshi Ishiyama, Toshiyuki Yoshio, Toshiaki Hirasawa, Yorimasa Yamamoto, Masatsugu Nagahama, Hiroshi Takahashi, Tomohiro Tsuchida
BACKGROUND: It is unknown how the accuracy rate of diagnostic demarcation of undifferentiated-type early gastric cancers (UD-type EGCs) differs between patients uninfected with Helicobacter pylori (H. pylori) and patients with and without H. pylori eradication. This study assessed and compared the diagnostic accuracy rate in the H. pylori-uninfected group and the non-H. pylori eradication and H. pylori eradication groups. METHODS: Subjects were 81 patients with 81 lesions who underwent endoscopic submucosal dissection between January 2010 and January 2015...
March 13, 2018: Gastric Cancer
Krishnan Raghunathan, Nora J Foegeding, Anne M Campbell, Timothy L Cover, Melanie D Ohi, Anne K Kenworthy
Helicobacter pylori , a Gram-negative bacterium, is a well-known risk factor for gastric cancer. H. pylori vacuolating cytotoxin A (VacA) is a secreted pore-forming toxin that induces a wide range of cellular responses. Like many other bacterial toxins, VacA has been hypothesized to utilize lipid rafts to gain entry into host cells. Here, we use Giant Plasma Membrane Vesicles (GPMVs) as a model system to understand the preferential partitioning of VacA into lipid rafts. We show that a wild-type toxin predominantly associates with the raft phase...
March 12, 2018: Infection and Immunity
Catarina Leal Seabra, Cláudia Nunes, Manuela Brás, Maria Gomez-Lazaro, Celso A Reis, Inês C Gonçalves, Salette Reis, M Cristina L Martins
Helicobacter pylori infection is one of the major risk factors for gastric cancer development. Available antibiotic-based treatments not only fail in around 20% of patients but also have a severe negative impact on the gut microbiota. Recently, we demonstrated that nanostructured lipid carriers (NLC), even without any drug loaded, are bactericidal against H. pylori at low concentrations. This work aims to clarify NLC mode of action and to evaluate if their bactericidal effect is specific to H. pylori without affecting bacteria from microbiota...
March 7, 2018: European Journal of Pharmaceutics and Biopharmaceutics
Bojan Tepes, Maja Seruga, Miroslav Vujasinovic, Dejan Urlep, Liljana Ljepovic, Jurecic Nataša Brglez, Alenka Forte, Ljubec Anita Kek, Miha Skvarc
Background: Gastric cancer is the fifth most common malignancy in the world with almost one million new cases annually. Helicobacter pylori infection causes 89% of all gastric cancers. Premalignant lesions (atrophy and intestinal metaplasia) develop after several decades of inflammation. Secondary prevention with gastroscopy is possible, but it is costly and has a low compliance rate. Alternative procedures like serology testing for pepsinogen I and II and pepsinogen I/II ratio are available to select patients for surveillance gastroscopies...
March 2018: Radiology and Oncology
Bojan Tepes, Marko Kastelic, Miroslav Vujasinovic, Polona Lampic, Maja Seruga, Natasa Brglez Jurecic, Olga P Nyssen, Maria G Donday, Colm O'Morain, Francis Megraud, Adrian G McNicholl, Javier P Gisbert
Background: Helicobacter pylori (H. pylori) is the most common chronic bacterial infection in the world affecting over 50% of the world's population. H. pylori is a grade I carcinogen, responsible for the development of 89 % of noncardia gastric cancers. In the present study we analyzed the data for H. pylori eradication treatments in Slovenia. Patients and methods: Slovenia is a part of the European Registry on Helicobacter pylori Management from the beginning...
March 2018: Radiology and Oncology
E Ray-Offor, C C Obiorah
Introduction: Helicobacter pylori (H. pylori)-related atrophic gastritis transits through a sequential pathway of intestinal metaplasia, dysplasia to gastric cancer. Gastroscopy offers early detection, treatment and surveillance of gastric cancer. Aims: This study aims to study the prevalence of H. pylori infection and evaluate precancerous lesions (PCLs) of the stomach. Patients and Methods: This is a case controlled study of patients with dyspepsia undergoing gastroscopy at a referral endoscopy facility in Port Harcourt metropolis of Nigeria...
March 2018: Nigerian Journal of Clinical Practice
Romano Schneider, Ioannis Lazaridis, Marko Kraljević, Christoph Beglinger, Bettina Wölnerhanssen, Ralph Peterli
BACKGROUND: Despite the increasing use of bariatric surgery as the most effective treatment of morbid obesity, there is still no consensus on its preoperative diagnostic workup. The aim of this study was to identify the pathologies of the endoscopic and radiologic investigations before performing bariatric surgery and to evaluate their impact on the patient management. METHODS: Retrospective analysis of prospectively collected data of 1225 consecutive patients who underwent laparoscopic Roux-en-Y gastric bypass (n = 834) or sleeve gastrectomy (n = 391) at our institution...
January 12, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
Giuseppe Corona, Renato Cannizzaro, Gianmaria Miolo, Laura Caggiari, Mariangela De Zorzi, Ombretta Repetto, Agostino Steffan, Valli De Re
A positive family history is a strong and consistently reported risk factor for gastric cancer (GC). So far, it has been demonstrated that serum pepsinogens (PGs), and gastrin 17 (G17) are useful for screening individuals at elevated risk to develop atrophic gastritis but they are suboptimal biomarkers to screen individuals for GC. The main purpose of this study was to investigate serum metabolomic profiles to find additional biomarkers that could be integrated with serum PGs and G17 to improve the diagnosis of GC and the selection of first-degree relatives (FDR) at higher risk of GC development...
March 7, 2018: International Journal of Molecular Sciences
Erika Hissong, Jose Jessurun, Rhonda K Yantiss
AIMS: Most gastric carcinomas develop in association with mucosal atrophy and hypochlorhydria, whereas benign peptic ulcers are acid-related. Given that acid sterilizes gastric contents, we hypothesized that ulcerated gastric cancers may be associated with increased luminal microbes compared with peptic ulcers, and that this feature may represent a helpful diagnostic clue to the presence of malignancy. We performed this study to determine whether features of luminal debris, including microorganisms, from ulcerated gastric cancers were significantly different from those of debris associated with benign ulcers...
March 8, 2018: Histopathology
Takako Osaki, Cynthia Zaman, Hideo Yonezawa, Yingsong Lin, Masumi Okuda, Eriko Nozaki, Fuhito Hojo, Satoshi Kurata, Tomoko Hanawa, Shogo Kikuchi, Shigeru Kamiya
Helicobacter pylori is a causative pathogen of chronic gastritis, gastric ulcer disease, and gastric cancer. Humans are known to be a natural host for H. pylori and tend to acquire the pathogen before the age of 5 years. The infection may then persist lifelong if eradication therapy is not applied. One of the modes of transmission of H. pylori is between family members, and therefore, the presence of infected family members is an important risk factor in children. However, other environmental factors have not been fully analyzed...
2018: Frontiers in Immunology
Masaaki Kodama, Tadayoshi Okimoto, Kazuhiro Mizukami, Hisanori Abe, Ryo Ogawa, Kazuhisa Okamoto, Mitsutaka Shuto, Osamu Matsunari, Yuka Hirashita, Ryugo Sato, Takashi Abe, Takayuki Nagai, Tsuyoshi Arita, Kazunari Murakami
BACKGROUND/AIMS: The rate of gastric cancer (GC) after Helicobacter pylori eradication has gradually increased; therefore, we investigate the clinicopathological features of GC following eradication in comparison with those of GC with H. pylori infection. METHODS: This study included 50 subjects with GC after eradication (GCE) and 151 patients with GC with H. pylori infection (GCI). Clinicopathological factors were assessed. The manifestation of GC was further evaluated using immunohistochemical analysis and in situ hybridization...
March 7, 2018: Digestion
Wen Zhong Liu, Yong Xie, Hong Lu, Hong Cheng, Zhi Rong Zeng, Li Ya Zhou, Ye Chen, Jiang Bin Wang, Yi Qi Du, Nong Hua Lu
BACKGROUND: Since the 'Fourth Chinese National Consensus Report on the management of H. pylori infection' was published in 2012, three important consensuses (Kyoto global consensus report on H. pylori gastritis, The Toronto Consensus for the Treatment of H. pylori Infection in Adults and Management of H. pylori infection-the Maastricht V/Florence Consensus Report) have been published regarding the management of H. pylori infection. MATERIALS AND METHODS: A Delphi method was adopted to develop the consensus of relevant 'statements'...
March 7, 2018: Helicobacter
Renu Verma, Prakash C Sharma
Gastric cancer (GC) is one of the leading causes of cancer related mortality in the world. Being asymptomatic in nature till advanced stage, diagnosis of gastric cancer becomes difficult in early stages of the disease. The onset and progression of gastric cancer has been attributed to multiple factors including genetic alterations, epigenetic modifications, Helicobacter pylori and Epstein-Barr Virus (EBV) infection, and dietary habits. Next Generation Sequencing (NGS) based approaches viz . Whole Genome Sequencing (WGS), Whole Exome Sequencing (WES), RNA-Seq, and targeted sequencing have expanded the knowledge base of molecular pathogenesis of gastric cancer...
2018: American Journal of Cancer Research
Mohammad Abu-Lubad, Hamed Alzoubi, Dua'a Jarajreh, Alaa Al Sawalqa, Holger Bruggemann, Eman Albataineh, Amin Aqel, Munir Al-Zeer
Background: Helicobacter pylori ( H. pylori ) infection has been associated with gastritis, gastric ulcer, mucosa-associated lymphoid tissue lymphoma and gastric cancer. The prevalence of H. pylori virulence genes have been studied in different populations and from different sources of samples but their prevalence has not been studied in dental plaque in Jordanian people; therefore, the aim of this study was to determine the genotypes of H. pylori isolated from dental plaque samples. Methods: Dental plaque samples were collected from 60 Jordanian volunteers...
February 2018: Gastroenterology Research
Ali Pormohammad, Reza Ghotaslo, Hamed Ebrahimzadeh Leylabadlo, Mohammad Javad Nasiri, Hossein Dabiri, Ali Hashemi
INTRODUCTION: It has been proposed that specific analysis of Helicobacter pylori virulence factors can be suitable for predicting of post H. pylori infection disorders like gastric cancer (GC). The present study was designed to evaluate the association between different virulence factors of H. pylori and GC. METHODS: Studies investigated the association between virulence factors of H. pylori and GC were collected from the several databases. All analysis was performed by Comprehensive Meta-Analysis V2...
March 3, 2018: Microbial Pathogenesis
Anla Hu, Li Li, Chuanlai Hu, Daoming Zhang, Chen Wang, Yan Jiang, Meng Zhang, Chunmei Liang, Wenjun Chen, Qingli Bo, Qihong Zhao
Helicobacter pylori (H. pylori) infection can interfere with the absorption of most elements, and the variations of some element levels are related to the incidence of gastric cancer. However, there have been conflicting results concerning the influence of H. pylori infection on serum element levels. The present study aimed to compare the serum element concentrations of H. pylori-infected local residents with uninfected residents from Lujiang County with high gastric cancer risk in Eastern China. We used data and serum samples from the H...
March 3, 2018: Biological Trace Element Research
Khean-Lee Goh
The study of Helicobacter pylori in Malaysia has given several important insights into the epidemiology of the infection and pathogenesis of disease. Malaysia has a multiracial Asian population with three major Asian races living together- Malay, Chinese and Indian. Races remain fairly distinct because of a paucity of inter-racial marriages. The "Racial Cohort Hypothesis" proposes that the infection occurs within racial groups rather than between. As such the high prevalence amongst Indians (>50%) and Chinese (40-50%) reflects the high prevalence in their countries of origin even though migration had taken place more than two generations before...
March 2, 2018: Journal of Gastroenterology and Hepatology
Yi-Chia Lee, Masahiro Asaka, David Y Graham
No abstract text is available yet for this article.
March 2, 2018: Helicobacter
Tran Thanh Binh, Vo Phuoc Tuan, Ho Dang Quy Dung, Pham Huu Tung, Tran Dinh Tri, Ngo Phuong Minh Thuan, Le Quang Tam, Bui Chi Nam, Do Anh Giang, Phan Quoc Hoan, Tomohisa Uchida, Tran Thi Huyen Trang, Vu Van Khien, Yoshio Yamaoka
The Helicobacter pylori -induced burden of gastric cancer varies based on geographical regions and ethnic grouping. Vietnam is a multiethnic country with the highest incidence of gastric cancer in Southeast Asia, but previous studies focused only on the Kinh ethnic group. A population-based cross-sectional study was conducted using 494 volunteers (18-78 years old), from 13 ethnic groups in Daklak and Lao Cai provinces, Vietnam. H. pylori status was determined by multiple tests (rapid urease test, culture, histology, and serology)...
March 1, 2018: International Journal of Molecular Sciences
Tomokazu Ohishi, Tohru Masuda, Hikaru Abe, Chigusa Hayashi, Hayamitsu Adachi, Shun-Ichi Ohba, Masayuki Igarashi, Takumi Watanabe, Hitomi Mimuro, Eri Amalia, Daniel Ken Inaoka, Kota Mochizuki, Kiyoshi Kita, Masakatsu Shibasaki, Manabu Kawada
BACKGROUND: Helicobacter pylori (H. pylori) infection causes various gastrointestinal diseases including gastric cancer. Hence, eradication of this infection could prevent these diseases. The most popular first-line treatment protocol to eradicate H. pylori is termed "triple therapy" and consists of a proton pump inhibitor (PPI), clarithromycin, and amoxicillin or metronidazole. However, the antibiotics used to treat H. pylori infection are hindered by the antibiotics-resistant bacteria and by their antimicrobial activity against intestinal bacteria, leading to side effects...
February 28, 2018: Helicobacter
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