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metallothioneins

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https://www.readbyqxmd.com/read/28109307/novel-roles-of-dc-signr-in-colon-cancer-cell-adhesion-migration-invasion-and-liver-metastasis
#1
Heya Na, Xiaoli Liu, Xiaomeng Li, Xinsheng Zhang, Yu Wang, Zhaohui Wang, Menglang Yuan, Yu Zhang, Shuangyi Ren, Yunfei Zuo
BACKGROUND: Tumor metastasis is an essential cause of the poor prognosis of colon cancer. DC-SIGNR is a C-type lectin that is frequently found on human liver sinusoidal endothelial cells. LSECtin, which is a homologue of DC-SIGNR, has been demonstrated to participate in colon cancer liver metastasis. Due to the similarities in the expression pattern and structure of the two proteins, we speculated that DC-SIGNR could also be involved in this process. METHODS: Colon cancer cells were treated with the DC-SIGNR protein or control IgG, after which cell migration, invasion, and morphology were assayed...
January 21, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28101932/amino-acid-profiling-of-zinc-resistant-prostate-cancer-cell-lines-associations-with-cancer-progression
#2
Monika Kratochvilova, Martina Raudenska, Zbynek Heger, Lukas Richtera, Natalia Cernei, Vojtech Adam, Petr Babula, Marie Novakova, Michal Masarik, Jaromir Gumulec
BACKGROUND: Failure in intracellular zinc accumulation is a key process in prostate carcinogenesis. Nevertheless, epidemiological studies of zinc administration have provided contradicting results. In order to examine the impact of the artificial intracellular increase of zinc(II) ions on prostate cancer metabolism, PNT1A, 22Rv1, and PC-3 prostatic cell lines-depicting different stages of cancer progression-and their zinc-resistant counterparts were used. To determine "benign" and "malignant" metabolic profiles, amino acid patterns, gene expression, and antioxidant capacity of these cell lines were assessed...
January 19, 2017: Prostate
https://www.readbyqxmd.com/read/28100752/differential-vulnerability-of-ca1-versus-ca3-pyramidal-neurons-after-ischemia-possible-relationship-to-sources-of-zn2-accumulation-and-its-entry-into-and-prolonged-effects-on-mitochondria
#3
Yuliya V Medvedeva, Sung G Ji, Hong Z Yin, John H Weiss
: Excitotoxic mechanisms contribute to the degeneration of hippocampal pyramidal neurons after recurrent seizures and brain ischemia. However, susceptibility differs, with CA1 neurons degenerating preferentially after global ischemia and CA3 neurons after limbic seizures. Whereas most studies address contributions of excitotoxic Ca(2+) entry, it is apparent that Zn(2+) also contributes, reflecting accumulation in neurons either after synaptic release and entry through postsynaptic channels or upon mobilization from intracellular Zn(2+)-binding proteins such as metallothionein-III (MT-III)...
January 18, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28087193/immunohistochemical-study-of-metallothionein-in-patients-with-temporal-lobe-epilepsy
#4
Daniel Juárez-Rebollar, Mario Alonso-Vanegas, Concepción Nava-Ruíz, Masao Buentello-García, Petra Yescas-Gómez, Araceli Díaz-Ruíz, Camilo Rios, Marisela Méndez-Armenta
Epilepsy is characterized by spontaneous recurrent seizures and temporal lobe epilepsy (TLE) is the most common serious neurological example of acquired and frequent epilepsy. Oxidative stress is recognized as playing a contributing role in several neurological disorders, and most recently have been implicated in acquired epilepsies. The MTs occur in several brain regions and may serve as neuroprotective proteins against reactive oxygen species causing oxidative damage and stress. The main aim of this work was to describe the immunohistochemical localization of MT in the specimens derived from the patients affected by TLE...
January 10, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28081447/hepatic-transcriptional-responses-to-copper-in-the-three-spined-stickleback-are-affected-by-their-pollution-exposure-history
#5
Tamsyn M Uren Webster, Tim D Williams, Ioanna Katsiadaki, Anke Lange, Ceri Lewis, Janice A Shears, Charles R Tyler, Eduarda M Santos
Some fish populations inhabiting contaminated environments show evidence of increased chemical tolerance, however the mechanisms contributing to this tolerance, and whether this is heritable, are poorly understood. We investigated the responses of two populations of wild three-spined stickleback (Gasterosteus aculeatus) with different histories of contaminant exposure to an oestrogen and copper, two widespread aquatic pollutants. Male stickleback originating from two sites, the River Aire, with a history of complex pollution discharges, and Siblyback Lake, with a history of metal contamination, were depurated and then exposed to copper (46μg/L) and the synthetic oestrogen ethinyloestradiol (22ng/L)...
December 31, 2016: Aquatic Toxicology
https://www.readbyqxmd.com/read/28076652/estimation-of-benchmark-dose-of-lifetime-cadmium-intake-for-adverse-renal-effects-using-hybrid-approach-in-inhabitants-of-an-environmentally-exposed-river-basin-in-japan
#6
Keiko Kubo, Kazuhiro Nogawa, Teruhiko Kido, Muneko Nishijo, Hideaki Nakagawa, Yasushi Suwazono
The aim of this study is to estimate the reference level of lifetime cadmium intake (LCd) as the benchmark doses (BMDs) and their 95% lower confidence limits (BMDLs) for various renal effects by applying a hybrid approach. The participants comprised 3,013 (1,362 men and 1,651 women) and 278 (129 men and 149 women) inhabitants of the Cd-polluted and nonpolluted areas, respectively, in the environmentally exposed Kakehashi River basin. Glucose, protein, aminonitrogen, metallothionein, and β2 -microglobulin in urine were measured as indicators of renal dysfunction...
January 11, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28074227/heavy-metals-in-liver-and-brain-of-waterfowl-from-the-evros-delta-greece
#7
Maria Aloupi, Asimina Karagianni, Savas Kazantzidis, Triantaphyllos Akriotis
The concentrations of six heavy metals (cadmium [Cd], chromium [Cr], copper [Cu], manganese [Mn], lead [Pb], and zinc [Zn]) were determined in liver and brain of nine species of waterfowl from the Evros Delta, one of the most important wetlands in Greece, to assess metal contamination and potential risk to waterfowl. Significant differences among species were found for hepatic Cr, Cu, Pb, and Zn; the highest levels of all metals were found in liver of mute swans. Cd increased significantly with age in both organs of wigeon; some differences were also observed between males and females of the same species...
January 10, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28070326/effects-of-cranberry-extracts-on-gene-expression-in-thp-1-cells
#8
Daniel B Hannon, Jerry T Thompson, Christina Khoo, Vijaya Juturu, John P Vanden Heuvel
Cranberry contains high levels of nutrients and bioactive molecules that have health-promoting properties. The purpose of the present studies was to determine if cranberry extracts (CEs) contain phytochemicals that exert anti-inflammatory effects. The human monocytic cell line THP-1 was treated with two CEs (CE and 90MX) and subsequently challenged with Lipopolysaccharides (LPS). Tumor necrosis factor α (TNF α) expression was decreased in the CE-treated cells, indicative of an anti-inflammatory effect. Gene expression microarrays identified several immune-related genes that were responsive to CEs including interferon-induced protein with tetratricopeptide repeats 1 and 3 (IFIT 1 and 3), macrophage scavenger receptor 1 (MSR1) and colony-stimulating factor 2 (CSF2)...
January 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/28068416/growth-enhanced-transgenic-coho-salmon-oncorhynchus-kisutch-strains-have-varied-success-in-simulated-streams-implications-for-risk-assessment
#9
Rosalind A Leggatt, L Fredrik Sundström, Krista Woodward, Robert H Devlin
Growth hormone (GH) transgenic fish have accelerated growth and could improve production efficiency in aquaculture. However, concern exists regarding potential environmental risks of GH transgenic fish should they escape rearing facilities. While environmental effects have been examined in some GH transgenic models, there is a lack of information on whether effects differ among different constructs or strains of transgenic fish. We compared growth and survival of wild-type coho salmon (Oncorhynchus kisutch) fry, a fast-growing GH transgenic strain containing a metallothionein promoter (TMT), and three lines/strains containing a reportedly weaker histone-3 promoter (TH3) in hatchery conditions and semi-natural stream tanks with varying levels of natural food and predators...
2017: PloS One
https://www.readbyqxmd.com/read/28068390/effect-of-inulin-on-proteome-changes-induced-by-pathogenic-lipopolysaccharide-in-human-colon
#10
Michele Pier Luca Guarino, Annamaria Altomare, Simone Barera, Vittoria Locato, Silvia Cocca, Cinzia Franchin, Giorgio Arrigoni, Candida Vannini, Sarah Grossi, Paola Campomenosi, Valentina Pasqualetti, Marcella Bracale, Rossana Alloni, Laura De Gara, Michele Cicala
In the present study, the protective role of inulin against lipopolysaccharide (LPS)-induced oxidative stress was evaluated on human colonic mucosa using a proteomic approach. Human colonic mucosa and submucosa were sealed between two chambers, with the luminal side facing upwards and overlaid with Krebs (control), LPS or LPS+ inulin IQ solution. The solutions on the submucosal side (undernatants) were collected following 30 min of mucosal exposure. iTRAQ based analysis was used to analyze the total soluble proteomes from human colonic mucosa and submucosa treated with different undernatants...
2017: PloS One
https://www.readbyqxmd.com/read/28061540/metallothionein-2a-an-interactive-protein-linking-phosphorylated-fadd-to-nf-%C3%AE%C2%BAb-pathway-leads-to-colorectal-cancer-formation
#11
Faiz M M T Marikar, Guanghui Jin, Wang Sheng, Dingyuan Ma, Zichun Hua
BACKGROUND: The rapid increase in the incidence rate of colorectal cancer has led to the search and identification of biomarkers that can predict risk for and future behavior of this malignancy and management. To study the biological role of the phosphorylated Fas associated death domain (pFADD) gene in colorectal cancer, we performed a GAL4-based yeast two-hybrid screening of a human heart cDNA library. METHODS: A series of two yeast hybrid method was used to identification of protein-protein interaction...
December 2016: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28061414/the-daphnia-magna-role-to-predict-the-cadmium-toxicity-of-sediment-bioaccumlation-and-biomarker-response
#12
Xiaomin Li, Weihua Peng, Yanyan Jiang, Yong Duan, Jinqian Ren, Yingying Liu, Wenhong Fan
To evaluate Daphnia magna role to predict the Cd toxicity in contaminated sediment, the Cd accumulation, metallothionein (MT), and mortality of D. magna exposed to overlying water system or water-sediment coexistence system were measured. The mortality, Cd accumulation, and MT in D. magna increased with the increasing Cd content in sediment. The Cd accumulation and MT in D. magna exposed to the coexistence system were significantly higher than those exposed to the overlying water system because of the ingestion of Cd-containing sediments by D...
January 3, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28059470/levels-of-heavy-metals-and-their-binding-protein-metallothionein-in-type-2-diabetics-with-kidney-disease
#13
Martina Raudenska, Veronika Dvorakova, Lukas Pacal, Katarina Chalasova, Monika Kratochvilova, Jaromir Gumulec, Branislav Ruttkay-Nedecky, Ondrej Zitka, Katerina Kankova, Vojtech Adam, Michal Masarik
Hyperglycemia, a major metabolic disturbance present in diabetes, promotes oxidative stress. Activation of antioxidant defense is an important mechanism to prevent cell damage. Levels of heavy metals and their binding proteins can contribute to oxidative stress. Antiradical capacity and levels of metallothionein (MT), metals (zinc and copper), and selected antioxidants (bilirubin, cysteine, and glutathione) were determined in 70 type 2 diabetes mellitus (T2DM) subjects and 80 healthy subjects of Caucasian origin...
January 6, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28055263/digestive-cell-lysosomes-as-main-targets-for-ag-accumulation-and-toxicity-in-marine-mussels-mytilus-galloprovincialis-exposed-to-maltose-stabilised-ag-nanoparticles-of-different-sizes
#14
A Jimeno-Romero, E Bilbao, U Izagirre, M P Cajaraville, I Marigómez, M Soto
Bioavailability and toxicity of maltose-stabilised AgNPs of different sizes (20, 40 and 100 nm) in mussels were compared with bulk and aqueous forms of the metal through a two-tier experimental approach. In the 1(st) tier, mussels were exposed for 3 d to a range of concentrations (0.75, 75, 750 µg Ag/l) in the form of Ag20-Mal, Ag40-Mal, Ag100-Mal, bulk Ag and aqueous Ag (as AgNO3), as well as to the concentrations of maltose used in the formulation of NPs. Mortality, bioaccumulation, tissue and cell distribution and lysosomal responses were investigated...
January 5, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28043837/targeting-antioxidant-enzyme-expression-as-a-therapeutic-strategy-for-ischemic-stroke
#15
REVIEW
Stephanie M Davis, Keith R Pennypacker
During ischemic stroke, neurons and glia are subjected to damage during the acute and neuroinflammatory phases of injury. Production of reactive oxygen species (ROS) from calcium dysregulation in neural cells and the invasion of activated immune cells are responsible for stroke-induced neurodegeneration. Scientists have failed thus far to identify antioxidant-based drugs that can enhance neural cell survival and improve recovery after stroke. However, several groups have demonstrated success in protecting against stroke by increasing expression of antioxidant enzymes in neural cells...
December 30, 2016: Neurochemistry International
https://www.readbyqxmd.com/read/28043034/oxidative-stress-biomarkers-cholinesterase-activity-and-biotransformation-enzymes-in-the-liver-of-dice-snake-natrix-tessellata-laurenti-during-pre-hibernation-and-post-hibernation-a-possible-correlation-with-heavy-metals-in-the-environment
#16
Jelena Gavrić, Marko Anđelković, Ljiljana Tomović, Marko Prokić, Svetlana Despotović, Branka Gavrilović, Tijana Radovanović, Slavica Borković-Mitić, Slađan Pavlović, Zorica Saičić
We investigated in the liver of dice snakes during pre- and post-hibernation changes in the following antioxidant parameters: total, manganese and copper zinc containing superoxide dismutases (Tot SOD, MnSOD, CuZn SOD, respectively), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR) and the concentrations of total glutathione (GSH) and sulfhydryl groups (-SH). In addition, we examined the expression of phase I biotransformation enzyme cytochrome P4501A (CYP1A) and the activity of phase II biotransformation enzyme glutathioneS-transferase (GST), the level of lipid peroxidation (by measuring the thiobarbituric acid-reactive substances (TBARS)), cholinesterase activity (ChE) and metallothionein expression (MT)...
December 30, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28040618/oxidative-damage-ultrastructural-alterations-and-gene-expressions-of-hemocytes-in-the-freshwater-crab-sinopotamon-henanense-exposed-to-cadmium
#17
Yanying Zhou, Weixin Jing, Hans-Uwe Dahms, Jiang-Shiou Hwang, Lan Wang
Toxicity of Cd was tested with the hemocytes of the freshwater crab, Sinopotamon henanense, which were exposed to concentrations of 0, 0.725, 1.450, and 2.900mgL(-1) Cd for 7, 14 and 21 d. We investigated the effects of Cd on the total antioxidant capacity (TAC), and oxidative damage of biomarkers, such as malondialdehyde (MDA), protein carbonyl derivates (PCO), and DNA-protein crosslink (DPC). Transmission electron microscopy (TEM) was applied to assess ultrastructural changes of hemocytes. The mRNA expression levels of prophenoloxidase (proPO), lysozyme (LSZ), metallothionein (MT), and the activity of phenoloxidase (PO) were also determined...
December 29, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28038424/effects-of-sub-chronic-exposure-to-lead-pb-and-ascorbic-acid-in-juvenile-rockfish-antioxidant-responses-mt-gene-expression-and-neurotransmitters
#18
Jun-Hwan Kim, Ju-Chan Kang
Juvenile rockfish Sebastes schlegelii were exposed to varying levels of dietary lead (Pb(2+)) at 0, 120 and 240 mg/L, and ascorbic acid (AsA) at 100, 200 and 400 mg/L for four weeks. Antioxidant responses such as superoxide dismutase (SOD), glutathione S-transferase (GST), and glutathione (GSH) were analyzed to assess oxidative stress. SOD and GST activity in the liver and gills were considerably elevated by dietary Pb. In contrast, GSH levels in the liver and gills were significantly reduced following Pb exposure...
December 21, 2016: Chemosphere
https://www.readbyqxmd.com/read/28034561/nanoparticulate-versus-ionic-silver-behavior-in-the-tank-water-bioaccumulation-elimination-and-subcellular-distribution-in-the-freshwater-mussel-dreissena-polymorpha
#19
Sonja Zimmermann, Nadine Ruchter, Kateryna Loza, Matthias Epple, Bernd Sures
Zebra mussels (Dreissena polymorpha) were exposed to polyvinylpyrrolidone (PVP)-coated silver nanoparticles (AgNP; hydrodynamic diameter 80 nm; solid diameter 50 nm) to investigate the behavior of Ag in the tank water with respect to its uptake, bioaccumulation, elimination and subcellular distribution in the mussel soft tissue. Parallel experiments were performed with ionic Ag (AgNO3) to unravel possible differences between the metal forms. The recovery of the applied Ag concentration (500 μg/L) in the tank water was clearly affected by the metal source (AgNP < AgNO3) and water type (reconstituted water < tap water)...
December 26, 2016: Environmental Pollution
https://www.readbyqxmd.com/read/28033516/early-and-efficient-induction-of-antioxidant-defense-system-in-mytilus-galloprovincialis-embryos-exposed-to-metals-and-heat-stress
#20
Khouloud Boukadida, Jérôme Cachot, Christelle Clérandeaux, Pierre-Yves Gourves, Mohamed Banni
: The present study aims to elucidate the stress response of early life stages of Mytilus galloprovincialis to the combine effects of selected metals and elevated temperature. For this purpose, we investigated the response of a large panel of oxidative stress markers such as catalase (CAT), superoxide dismutase (SOD), glutathione-S-transferase (GST) activities and lipid peroxidation (thiobarbituric acid reactive substrates (TBARS) concentration) and metallothionein accumulation (MT) as well as selected gene transcription level and metal accumulation in mussels larvae exposed to a sub-lethal concentration of Cu (9...
December 26, 2016: Ecotoxicology and Environmental Safety
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