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https://www.readbyqxmd.com/read/28527742/bio-monitoring-of-metal-impact-on-metallothioneins-levels-in-the-gastropod-phorcus-turbinatus-born-1778-in-the-northeastern-and-the-eastern-coasts-of-tunisia
#1
Wafa Boulajfene, Evangelia Strogyloudi, Catsiki Vassiliki-Angelique, Ammar El Mlayah, Sabiha Tlig-Zouari
This work is an evaluation of metal contamination degree in Phorcus turbinatus and a monitoring of metals impact on metallothioneins functioning. The gastropod was sampled from six stations along the northeastern and eastern coasts of Tunisia during four seasons (2014-2015). Our results suggested that sedimentological metallic contents (Copper, Zinc and Cadmium) vary significantly depending on stations and not significantly according to seasons except for copper. Nevertheless, differences were no significant between stations and significant between seasons as for ambient factors, metallic intrinsic contents and metallothioneins rates...
May 17, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28525556/transcriptome-of-the-gsh-depleted-lens-reveals-changes-in-detoxification-and-emt-signaling-genes-transport-systems-and-lipid-homeostasis
#2
Jeremy A Whitson, Xiang Zhang, Mario Medvedovic, Jenny Chen, Zongbo Wei, Vincent M Monnier, Xingjun Fan
Purpose: To understand the effects of glutathione (GSH)-deficiency on genetic processes that regulate lens homeostasis and prevent cataractogenesis. Methods: The transcriptome of lens epithelia and fiber cells was obtained from C57BL/6 LEGSKO (lens GSH-synthesis knockout) and buthionine sulfoximine (BSO)-treated LEGSKO mice and compared to C57BL/6 wild-type mice using RNA-Seq. Transcriptomic data were confirmed by qPCR and Western blot/ELISA on a subset of genes...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28513591/zinc-is-a-potent-and-specific-inhibitor-of-ifn-%C3%AE-3-signalling
#3
Scott A Read, Kate S O'Connor, Vijay Suppiah, Chantelle L E Ahlenstiel, Stephanie Obeid, Kristina M Cook, Anthony Cunningham, Mark W Douglas, Philip J Hogg, David Booth, Jacob George, Golo Ahlenstiel
Lambda interferons (IFNL, IFN-λ) are pro-inflammatory cytokines important in acute and chronic viral infection. Single-nucleotide polymorphisms rs12979860 and rs8099917 within the IFNL gene locus predict hepatitis C virus (HCV) clearance, as well as inflammation and fibrosis progression in viral and non-viral liver disease. The underlying mechanism, however, is not defined. Here we show that the rs12979860 CC genotype correlates with increased hepatic metallothionein expression through increased systemic zinc levels...
May 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28508186/effects-of-maternal-zinc-glycine-on-mortality-zinc-concentration-and-antioxidant-status-in-a-developing-embryo-and-1-day-old-chick
#4
Ling Zhang, Jiang-Shui Wang, Qian Wang, Kai-Xuan Li, Tian-Yu Guo, Xue Xiao, Yong-Xia Wang, Xiu-An Zhan
This study was conducted to investigate the effects of maternal zinc glycine (Zn-Gly) supplementation as an alternative for zinc sulfate (ZnSO4) on mortality, zinc (Zn) concentration, and antioxidant status in a developing embryo and 1-day-old chick. Six hundred 39-week-old broiler breeders were randomly assigned to 6 treatments, each treatment including 5 replicates with 20 birds each. Six treatments received a basal diet (control, 24 mg Zn/kg diet) or a basal diet supplemented with ZnSO4 (80 mg Zn/kg) or Zn-Gly (20, 40, 60, or 80 mg Zn/kg), respectively...
May 15, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28507149/identification-of-xaf1-mt2a-mutual-antagonism-as-a-molecular-switch-in-cell-fate-decisions-under-stressful-conditions
#5
Cheol-Hee Shin, Min-Goo Lee, Jikhyon Han, Seong-In Jeong, Byung-Kyu Ryu, Sung-Gil Chi
XIAP-associated factor 1 (XAF1) is a tumor suppressor that is commonly inactivated in multiple human neoplasms. However, the molecular mechanism underlying its proapoptotic function remains largely undefined. Here, we report that XAF1 induction by heavy metals triggers an apoptotic switch of stress response by destabilizing metallothionein 2A (MT2A). XAF1 directly interacts with MT2A and facilitates its lysosomal degradation, resulting in the elevation of the free intercellular zinc level and subsequent activation of p53 and inactivation of XIAP...
May 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28499224/interspecies-comparison-of-selected-pollution-biomarkers-in-dreissenid-spp-inhabiting-pristine-and-moderately-polluted-sites
#6
A Farkas, A Ács, Á Vehovszky, H Falfusynska, O Stoliar, A Specziár, J Győri
Stress biomarkers, which can outline impacts of contaminants in aquatic biota at the biochemical level, are increasingly used as early warning tools in environmental monitoring. Reliable biomarker based assessment schemes, however, request appropriate knowledge of baseline levels of selected endpoints, and the potential influence of a range of natural influencing factors (both abiotic and biotic) as well. In this study, we examined the interspecies variability of various biomarkers (metallothioneins (MT), ethoxyresorufin-O-deethylase activity (EROD), lipid peroxidation (LPO), DNA strand breaks (DNA_sb), vitellogenin-like proteins (Vtg)) in Dreissena polymorpha and Dreissena bugensis inhabiting either pristine- or moderately impacted sites of Lake Balaton (Hungary)...
May 9, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28492340/alterations-of-zinc-homeostasis-in-response-to-cryptococcus-neoformans-in-a-murine-macrophage-cell-line
#7
Francine Melise Dos Santos, Alícia Corbellini Piffer, Rafael de Oliveira Schneider, Nicole Sartori Ribeiro, Ane Wichine Acosta Garcia, Augusto Schrank, Lívia Kmetzsch, Marilene Henning Vainstein, Charley Christian Staats
AIM: To evaluate alterations of zinc homeostasis in macrophages exposed to Cryptococcus neoformans. Materials & methods: Using a fluorescent zinc probe-based flow cytometry and atomic absorption spectrometry, zinc levels were evaluated in J774.A1 cell lines exposed to C. neoformans H99 cells. The transcription profile of macrophage zinc related homeostasis genes - metallothioneins and zinc transporters (ZnTs) of the SLC30 and SLC39 (Zrt-Irt-protein) families - was analyzed by quantitative PCR...
May 11, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28490250/effects-of-acrylamide-graded-doses-on-metallothioneins-i-and-ii-induction-and-dna-fragmentation-bochemical-and-histomorphological-changes-in-the-liver-of-adult-rats
#8
Imen Ghorbel, Awatef Elwej, Mariem Chaabene, Ons Boudawara, Rim Marrakchi, Kamel Jamoussi, Tahya Sellami Boudawara, Najiba Zeghal
The present study investigates the toxic effects of acrylamide (ACR) administered to rats at two doses on (i) oxidative stress and disruption of pro-oxidant/antioxidant balance in hepatic cells and (ii) its correlation with metallothioneins (MTs) genes expression, DNA damage and histomorphological changes. Treated rats with 20 and 40 mg/kg body weight of ACR led to an increase in malondialdehyde, hydrogen peroxide, advanced oxidation protein products, protein carbonyl levels as well as an alteration in the antioxidant status...
January 1, 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/28488724/complex-effect-of-zinc-oxide-nanoparticles-on-cadmium-chloride-induced-hepatotoxicity-in-mice-protective-role-of-metallothionein
#9
Shang Gao, Xue Wang, Shasha Wang, Shanshan Zhu, Rui Rong, Xiaolong Xu
The wide range of applications of ZnO nanoparticles (nano ZnO) in commercial products and the ubiquitous cadmium (Cd) contamination in the natural environment increase the chance of co-existence of nano ZnO with Cd in the surroundings. To investigate the effects of nano ZnO on CdCl2-induced hepatotoxicity in mice, the histopathologic changes, metallothionein expression, oxidative stress responses and serum biochemical parameters were determined after oral administration of bulk or nano ZnO and/or CdCl2 for seven consecutive days...
May 10, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28488385/the-c-797-g-a-p-r266k-cystathionine-%C3%AE-synthase-mutation-causes-homocystinuria-by-affecting-protein-stability
#10
Sapna Gupta, Liqun Wang, Warren D Kruger
Mutations in the cystathionine beta-synthase (CBS) gene are the cause of classical homocystinuria, the most common inborn error in sulfur metabolism. The c.797 G>A (p.R266K) mutation in CBS was originally described in several Norwegian pyridoxine responsive CBS deficient patients, and heterologous gene expression studies have shown that the protein has near wild-type levels of enzyme activity. Here, we characterize a transgenic mouse lacking endogenous Cbs and expressing p.R266K human CBS protein from a zinc inducible metallothionein promoter (Tg-R266K Cbs-/-)...
May 10, 2017: Human Mutation
https://www.readbyqxmd.com/read/28483053/gm1-mmp-is-involved-in-growth-and-development-of-leaf-and-seed-and-enhances-tolerance-to-high-temperature-and-humidity-stress-in-transgenic-arabidopsis
#11
Sushuang Liu, Yanmin Liu, Yanhong Jia, Jiaping Wei, Shuang Wang, Xiaolin Liu, Yali Zhou, Yajing Zhu, Weihong Gu, Hao Ma
Matrix metalloproteinases (MMPs) are a family of zinc- and calcium-dependent endopeptidases. Gm1-MMP was found to play an important role in soybean tissue remodeling during leaf expansion. In this study, Gm1-MMP was isolated and characterized. Its encoding protein had a relatively low phylogenetic relationship with the MMPs in other plant species. Subcellular localization indicated that Gm1-MMP was a plasma membrane protein. Gm1-MMP showed higher expression levels in mature leaves, old leaves, pods, and mature seeds, as well as was involved in the development of soybean seed...
June 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/28482255/molecular-cloning-characterization-and-expression-analysis-of-metallothionein-in-the-liver-of-the-teleost-acrossocheilus-fasciatus-exposed-to-cadmium-chloride
#12
Guo-Di Liu, Zhang Sheng, Cong-Cong Hou, Jie Ni, Ying-Li Han, You-Fa Wang, Yang Zhou, Su-Yan Fu, Jun-Quan Zhu
Metallothionein (MT) has a characteristic molecular structure with a cysteine-rich content. This unique structure provides metal-binding and redox capabilities and promoting metal homeostasis and detoxification in living animals. In order to evaluate the effects of cadmium (Cd) on hepatic MT expression in the liver of Acrossocheilus fasciatus, we obtained the complete cDNA of the A. fasciatus liver MT for the first time. The MT cDNA contains a 605-bp sequence, which codes for 60 amino acids. Protein alignment showed that the similarity between MT protein sequences of A...
March 29, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28480491/double-genetically-modified-symbiotic-system-for-improved-cu-phytostabilization-in-legume-roots
#13
Patricia Pérez-Palacios, Asunción Romero-Aguilar, Julián Delgadillo, Bouchra Doukkali, Miguel A Caviedes, Ignacio D Rodríguez-Llorente, Eloísa Pajuelo
Excess copper (Cu) in soils has deleterious effects on plant growth and can pose a risk to human health. In the last decade, legume-rhizobium symbioses became attractive biotechnological tools for metal phytostabilization. For this technique being useful, metal-tolerant symbionts are required, which can be generated through genetic manipulation.In this work, a double symbiotic system was engineered for Cu phytostabilization: On the one hand, composite Medicago truncatula plants expressing the metallothionein gene mt4a from Arabidopsis thaliana in roots were obtained to improve plant Cu tolerance...
May 8, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28475128/erratum-irvine-g-w-tan-s-n-stillman-m-j-a-simple-metallothionein-based-biosensor-for-enhanced-detection-of-arsenic-and-mercury-biosensors-2017-7-14
#14
https://www.readbyqxmd.com/read/28474724/interaction-of-silver-nanoparticles-with-metallothionein-and-ceruloplasmin-impact-on-metal-substitution-by-ag-i-corona-formation-and-enzymatic-activity
#15
Wei Liu, Isabelle A M Worms, Nathalie Herlin-Boime, Delphine Truffier-Boutry, Isabelle Michaud-Soret, Elisabeth Mintz, Claude Vidaud, Françoise Rollin-Genetet
The release of Ag(i) from silver nanoparticles (AgNPs) unintentionally spread in the environment is suspected to impair some key biological functions. In comparison with AgNO3, in-depth investigations were carried out into the interactions between citrate-coated AgNPs (20 nm) and two metalloproteins, intracellular metallothionein 1 (MT1) and plasmatic ceruloplasmin (Cp), both involved in metal homeostasis. These were chosen for their physiological relevance and the diversity of their various native metals bound because of thiol groups and/or their structural differences...
May 18, 2017: Nanoscale
https://www.readbyqxmd.com/read/28473775/the-role-of-the-cephalopod-digestive-gland-in-the-storage-and-detoxification-of-marine-pollutants
#16
REVIEW
Ana P Rodrigo, Pedro M Costa
The relevance of cephalopods for fisheries and even aquaculture, is raising concerns on the relationship between these molluscs and environmental stressors, from climate change to pollution. However, how these organisms cope with environmental toxicants is far less understood than for other molluscs, especially bivalves, which are frontline models in aquatic toxicology. Although, sharing the same basic body plan, cephalopods hold distinct adaptations, often unique, as they are active predators with high growth and metabolic rates...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28471346/involvement-of-oxidative-stress-in-the-mechanism-of-p-p-ddt-induced-nephrotoxicity-in-adult-rats
#17
Neila Marouani, Dorsaf Hallegue, Mohsen Sakly, Moncef Benkhalifa, Khémais Ben Rhouma, Olfa Tebourbi
The 1,1,1-trichloro-2,2-bis(4-chlorophenyl) ethane (p,p'-DDT) is an organochlorine pesticide that persists in the environment and has a risk to human health. We investigated whether p,p'-DDT-induces nephrotoxicity in rats and whether oxidative stress and apoptosis are involved in the pathogenesis of this process. Male rats received the pesticide at doses of 50 and 100 mg/kg for 10 days. Renal damage was evaluated by histopathological examination and serum markers. The oxidative stress was evaluated by lipid peroxidation (LPO), metallothioneins (MTs) and protein carbonyl levels...
May 4, 2017: General Physiology and Biophysics
https://www.readbyqxmd.com/read/28471199/-zinc-modified-nanotransporter-for-target-drug-therapy-of-breast-cancer
#18
S Skaličková, M Gargulák, M Löffelmann, B Ruttkay-Nedecký, M Kepinská, T Parák, R Kizek
BACKGROUND: In the centre of nanomedical interest stands the nanotechnological modification of anthracycline antibiotics, which are often used in antitumor treatment of hematological malignancies and solid tumors. Chitosan nanoparticles are gaining more attention in the field of targeted transport of drugs because of their stability, low toxicity and simple preparation. The main objective of the project, was the design of chitosan nanotransporter of anthracycline antibiotics with zinc modified surface, for a specific interaction with metallothionein...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/28470349/cadmium-compartmentalization-in-the-pulmonate-snail-lymnaea-stagnalis-improving-our-understanding-of-exposure
#19
Evelyn G Reátegui-Zirena, Amanda D French, David M Klein, Christopher J Salice
In ecotoxicology, analytical compartmentalization analysis can be used to better understand metal sequestration and detoxification. Metals are typically found in two main compartments, biologically detoxified metal (BDM) and metal sensitive fractions (MSF). The purpose of this study was to analyze the subcellular distribution of cadmium (Cd) in Lymnaea stagnalis. Adult snails were exposed to three concentrations of Cd for 56 days as part of a global ring test for L. stagnalis. At the end of the 56-day exposure, organisms were separated in two sections (viscera and foot)...
May 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28469272/adult-murine-cardiomyocytes-exhibit-regenerative-activity-with-cell-cycle-reentry-through-stat3-in-the-healing-process-of-myocarditis
#20
Akimitsu Miyawaki, Masanori Obana, Yusuke Mitsuhara, Aya Orimoto, Yusuke Nakayasu, Tomomi Yamashita, So-Ichiro Fukada, Makiko Maeda, Hiroyuki Nakayama, Yasushi Fujio
Mammalian cardiomyocytes substantially lose proliferative capacity immediately after birth, limiting adult heart regeneration after injury. However, clinical myocarditis appears to be self-limiting with tissue-reparative properties. Here, we investigated the molecular mechanisms underlying the recovery from myocarditis with regard to cardiomyocyte proliferation using an experimental autoimmune myocarditis (EAM) model. Three weeks after EAM induction (EAM3w), cardiac tissue displayed infiltration of inflammatory cells with cardiomyocyte apoptosis...
May 3, 2017: Scientific Reports
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