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https://www.readbyqxmd.com/read/29909574/the-possible-antidiabetic-effects-of-vitamin-d-receptors-agonist-in-rat-model-of-type-2-diabetes
#1
Wafaa M Abdel-Rehim, Rasha A El-Tahan, Mennatullah A El-Tarawy, Rowaida R Shehata, Maher A Kamel
Vitamin D3 deficiency was found to be tightly linked to many health problems including metabolic syndrome, cancer, cardiovascular diseases, and type 2 diabetes mellitus. In our study, we tested the possible antidiabetic effects of one of vitamin D3 analogs, alfacalcidol, solely or in a combination with metformin on type 2 diabetic rats. Type 2 diabetic model rats were induced by feeding high-fat diet for 4 weeks followed by intraperitoneal injection of streptozotocin. In addition to the control group, the diabetic rats were divided into four groups: untreated, metformin-treated, alfacalcidol-treated, and combination-treated group (metformin + alfacalcidol) for 4 weeks...
June 16, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29909550/methods-for-measuring-risk-for-type-2-diabetes-in-youth-the-oral-glucose-tolerance-test-ogtt
#2
REVIEW
Melinda E Chen, Rebecca S Aguirre, Tamara S Hannon
PURPOSE OF REVIEW: The oral glucose tolerance test (OGTT) is used both in clinical practice and research to assess glucose tolerance. In addition, the OGTT is utilized for surrogate measures of insulin sensitivity and the insulin response to enteral glucose and has been widely applied in the evaluation of β-cell dysfunction in obesity, prediabetes, and type 2 diabetes. Here we review the use of the OGTT and the OGTT-derived indices for measurement of risk markers for type 2 diabetes in youth...
June 16, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29909517/metabolic-parameters-weight-loss-and-comorbidities-4-years-after-roux-en-y-gastric-bypass-and-sleeve-gastrectomy
#3
Corey J Lager, Nazanene H Esfandiari, Yingying Luo, Angela R Subauste, Andrew T Kraftson, Morton B Brown, Oliver A Varban, Rasimcan Meral, Ruth B Cassidy, Catherine K Nay, Amy L Lockwood, Darlene Bellers, Colleen M Buda, Elif A Oral
BACKGROUND: Sleeve gastrectomy (LSG) is now the predominant bariatric surgery performed, yet there is limited long-term data comparing important outcomes between LSG and Roux-en-Y gastric bypass (RYGB). This study compares weight loss and impact on comorbidities of the two procedures. METHODS: We retrospectively evaluated weight, blood pressure, hemoglobin A1c, cholesterol, and medication use for hypertension, diabetes, and hyperlipidemia at 1-4 years post-operatively in 380 patients who underwent RYGB and 334 patients who underwent LSG at the University of Michigan from January 2008 to November 2013...
June 16, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29909515/influence-of-biliopancreatic-diversion-on-pregnancy-outcomes-in-comparison-to-other-bariatric-surgery-procedures
#4
S De Carolis, A Botta, Gelsomina Del Sordo, R Guerrisi, S Salvi, M P De Carolis, A Iaconelli, P Giustacchini, M Raffaelli, A Lanzone
BACKGROUND: Pregnancy after bariatric surgery (BS) has an increased risk for small-for-gestational-age infants (SGA), shorter length of gestation, and probably perinatal mortality. The aim of this study was to investigate if biliopancreatic diversion could impair pregnancy outcomes in comparison to other bariatric surgery procedures. METHODS: We conducted a cohort retrospective single-center study in 65 women before and after BS. Thirty-one pregnancies occurred before BS, while 109 after BS, amongst which n = 51 after biliopancreatic diversion (BPD) and n = 58 after non-malabsorptive procedures...
June 16, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29909514/mid-term-4-year-outcomes-with-single-anastomosis-duodenal-ileal-bypass-with-sleeve-gastrectomy-surgery-at-a-single-us-center
#5
Hinali Zaveri, Amit Surve, Daniel Cottam, Austin Cottam, Walter Medlin, Christina Richards, LeGrand Belnap, Samuel Cottam, Benjamin Horsley
BACKGROUND: Single anastomosis duodenal-ileal bypass with sleeve gastrectomy (SADI-S) is a modification of Roux-en-Y duodenal switch (RYDS). Long-term data on this operation is lacking in the literature. We reviewed our mid-term data of this RYDS modification. PURPOSE: To analyze the outcomes with SADI-S at 4 years. METHODS: Data from patients who underwent a primary SADI-S procedure performed by three surgeons at a single institution from June 2013 through February 2018 were retrospectively reviewed...
June 16, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29909501/decreasing-rates-of-major-lower-extremity-amputation-in-people-with-diabetes-but-not-in-those-without-a-nationwide-study-in-belgium
#6
Heiner Claessen, Herve Avalosse, Joeri Guillaume, Maria Narres, Tatjana Kvitkina, Werner Arend, Stephan Morbach, Patrick Lauwers, Frank Nobels, Jacques Boly, Chris Van Hul, Kris Doggen, Isabelle Dumont, Patricia Felix, Kristien Van Acker, Andrea Icks
AIMS/HYPOTHESIS: The reduction of major lower-extremity amputations (LEAs) is one of the main goals in diabetes care. Our aim was to estimate annual LEA rates in individuals with and without diabetes in Belgium, and corresponding time trends. METHODS: Data for 2009-2013 were provided by the Belgian national health insurance funds, covering more than 99% of the Belgian population (about 11 million people). We estimated the age-sex standardised annual amputation rate (first per year) in the populations with and without diabetes for major and minor LEAs, and the corresponding relative risks...
June 16, 2018: Diabetologia
https://www.readbyqxmd.com/read/29909496/transplantation-of-macroencapsulated-insulin-producing-cells
#7
REVIEW
Albert J Hwa, Gordon C Weir
PURPOSE OF REVIEW: There is considerable interest in using macroencapsulation devices as a delivery strategy for transplanting insulin-producing cells. This review aims to summarize recent advances, to highlight remaining challenges, and to provide recommendations for the field. RECENT FINDINGS: A variety of new device designs have been reported to improve biocompatibility and to provide protection for islet/beta cells from immune destruction while allowing continuous secretion of insulin...
June 16, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29909478/correction-to-reproducibility-and-validity-of-a-questionnaire-measuring-treatment-burden-on-patients-with-type-2-diabetes-diabetic-treatment-burden-questionnaire-dtbq
#8
Hitoshi Ishii, Koki Shin, Takahiro Tosaki, Tatsuya Haga, Yoshiki Nakajima, Toshihiko Shiraiwa, Nobuaki Watanabe, Miyuki Koizumi, Hiroki Nakajima, Sadanori Okada, Tsuyoshi Mashitani, Takako Mohri, Yasuhiro Akai
In the original publication, second author's name was incorrectly published as Hiroki Shin. The correct name should read as 'Koki Shin'.
June 16, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29909468/a-high-incidence-and-coexistence-of-multiresistance-genes-cfr-and-optra-among-linezolid-resistant-enterococci-isolated-from-a-teaching-hospital-in-wenzhou-china
#9
Yizhi Zhang, Guofeng Dong, Jiahui Li, Lijiang Chen, Haiyang Liu, Wenzi Bi, Hong Lu, Tieli Zhou
Linezolid is considered as a last-resort antimicrobial agent, the resistance of which is of great concern. The aim of this study was to investigate the mechanisms and transferability of linezolid resistance and molecular epidemiology of linezolid-resistant enterococcal isolates in Wenzhou, China. A collection of 1623 enterococcal strains, including 789 Enterococcus faecalis and 834 Enterococcus faecium, were isolated from our hospital during 2011-2016. Antimicrobial susceptibility testing and clinical data analysis were performed...
June 16, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29909463/correction-to-the-effects-of-resveratrol-on-markers-of-oxidative-stress-in-patients-with-type-2-diabetes-a-randomized-double-blind-placebo-controlled-clinical-trial
#10
ShadiSadat Seyyedebrahimi, Hadi Khodabandehloo, Ensieh Nasli Esfahani, Reza Meshkani
Oxidative stress plays a pivotal role in the pathogenesis of type 2 diabetes (T2D). In vitro and animal studies have shown that resveratrol exerts an antioxidant effect, but clinical trials addressing this effect in patients with T2D are limited. The aim of this study was to determine whether resveratrol supplementation affects oxidative stress markers in a randomized, placebo-controlled, double-blind clinical trial.
June 16, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29909454/inhibition-of-toll-like-receptor-4-tlr-4-improves-neurobehavioral-outcomes-after-acute-ischemic-stroke-in-diabetic-rats-possible-role-of-vascular-endothelial-tlr-4
#11
Yasir Abdul, Mohammed Abdelsaid, Weiguo Li, R Clinton Webb, Jennifer C Sullivan, Guangkuo Dong, Adviye Ergul
Diabetes increases the risk of occurrence and poor functional recovery after ischemic stroke injury. Previously, we have demonstrated greater hemorrhagic transformation (HT), edema, and more severe functional deficits after stroke in diabetic animals that also presented with cerebral vasoregression and endothelial cell death in the recovery period. Given that Toll-like receptor 4 (TLR-4) activation in microvascular endothelial cells triggers a robust inflammatory response, we hypothesized that inhibition of TLR-4 signaling prevents endothelial cell death and improves outcomes after stroke...
June 16, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29909377/effect-of-aspirin-on-cancer-chemoprevention-in-japanese-patients-with-type-2-diabetes-10-year-observational-follow-up-of-a-randomized-controlled-trial
#12
Sadanori Okada, Takeshi Morimoto, Hisao Ogawa, Mio Sakuma, Chisa Matsumoto, Hirofumi Soejima, Masafumi Nakayama, Naofumi Doi, Hideaki Jinnouchi, Masako Waki, Izuru Masuda, Yoshihiko Saito
OBJECTIVE: This study analyzed the efficacy of low-dose aspirin in cancer chemoprevention in patients with diabetes. RESEARCH DESIGN AND METHODS: This study was a posttrial follow-up of the Japanese Primary Prevention of Atherosclerosis with Aspirin for Diabetes (JPAD) trial. Participants in the JPAD trial (2,536 Japanese patients with type 2 diabetes and without preexisting cardiovascular disease) were randomly allocated to receive aspirin (81 or 100 mg daily) or no aspirin...
June 16, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29909344/involvement-of-the-tgf%C3%AE-1-ilk-akt-signaling-pathway-in-the-effects-of-hesperidin-in-type-2-diabetic-nephropathy
#13
YingHui Zhang, Bing Wang, Feng Guo, ZhiZhen Li, GuiJun Qin
Diabetic nephropathy is one of the manifestations of systemic microangiopathy in diabetes. Hesperetin, a natural flavanone glycoside compound in citrus fruits, has been demonstrated to exert hypoglycemic effects and protect kidney in experimental diabetic animals. The current study was aimed to investigate the mechanisms underlying the hypoglycemic effects of hesperetin in high-fat/streptozocin (STZ)-induced diabetic nephropathy. The results showed that mice in whom hesperetin was administered for 4 weeks attenuated the increased fasting blood glucose and impaired glucose tolerance ability that was observed in high-fat/STZ mice...
June 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29909315/effects-of-bisphenol-s-on-hypothalamic-neuropeptides-regulating-feeding-behavior-and-apelin-apj-system-in-mice
#14
Raja Rezg, Anne Abot, Bessem Mornagui, Samir Aydi, Claude Knauf
Since 2010, Bisphenol A (BPA), an endocrine disruptor has been restricted and replaced by analogues like Bisphenol S (BPS). However, little is known about BPS effects and growing concern have suspected the "BPA-free" Label. Several recent studies suggest that BPS is associated with increased risk of diabetes and obesity. However, the underlying mechanisms remain unidentified. The current study investigates investigate BPS effects on hypothalamic neuropeptides regulating feeding behavior, either orexigenic or anorexigenic in Swiss Albino mice...
June 14, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29909238/autophagy-as-an-emerging-target-in-cardiorenal-metabolic-disease-from-pathophysiology-to-management
#15
REVIEW
Yingmei Zhang, Adam T Whaley-Connell, James R Sowers, Jun Ren
Although advances in medical technology and health care have improved the early diagnosis and management for cardiorenal metabolic disorders, the prevalence of obesity, insulin resistance, diabetes, hypertension, dyslipidemia, and kidney disease remains high. Findings from numerous population-based studies, clinical trials, and experimental evidence have consolidated a number of theories for the pathogenesis of cardiorenal metabolic anomalies including resistance to the metabolic action of insulin, abnormal glucose and lipid metabolism, oxidative and nitrosative stress, endoplasmic reticulum (ER) stress, apoptosis, mitochondrial damage, and inflammation...
June 15, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29909237/glycosylation-as-new-pharmacological-strategies-for-diseases-associated-with-excessive-angiogenesis
#16
REVIEW
Simon Bousseau, Luisa Vergori, Raffaella Soleti, Guy Lenaers, M Carmen Martinez, Ramaroson Andriantsitohaina
Angiogenesis is a complex process describing the growth of new blood vessels from existing vasculature, and is triggered by local pro-angiogenic factors, such as vascular endothelial growth factor (VEGF), which increase the metabolism of endothelial cells (ECs). Angiogenesis takes part in various physiological conditions such as embryogenesis, placental growth, and in pathological conditions such as tumor growth, diabetic retinopathy, rheumatoid arthritis (RA) and ischemic diseases. Current therapies against excessive angiogenesis target vascular growth signaling...
June 14, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29909200/epigenetic-control-of-variation-and-stochasticity-in-metabolic-disease
#17
REVIEW
Ilaria Panzeri, John Andrew Pospisilik
BACKGROUND: The alarming rise of obesity and its associated comorbidities represents a medical burden and a major global health and economic issue. Understanding etiological mechanisms underpinning susceptibility and therapeutic response is of primary importance. Obesity, diabetes, and metabolic diseases are complex trait disorders with only partial genetic heritability, indicating important roles for environmental programing and epigenetic effects. SCOPE OF THE REVIEW: We will highlight some of the reasons for the scarce predictability of metabolic diseases...
May 18, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29909196/bioelectronic-organ-based-sensor-for-microfluidic-real-time-analysis-of-the-demand-in-insulin
#18
R Perrier, A Pirog, M Jaffredo, J Gaitan, B Catargi, S Renaud, M Raoux, J Lang
On-line and real-time analysis of micro-organ activity permits to use the endogenous analytical power of cellular signal transduction algorithms as biosensors. We have developed here such a sensor using only a few pancreatic endocrine islets and the avoidance of transgenes or chemical probes reduces bias and procures general usage. Nutrient and hormone-induced changes in islet ion fluxes through channels provide the first integrative read-out of micro-organ activity. Using extracellular electrodes we captured this read-out non-invasively as slow potentials which reflect glucose concentration-dependent (3-15 mM) micro-organ activation and coupling...
June 8, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29909161/-host-microbiota-crosstalk-and-cardiovascular-diseases
#19
Jacques Amar
When analyzing the microbiota-host crosstalk, we have to consider three participants in this dialogue: the gut microbiota, the intestinal barrier and bacterial translocation. Experimental data demonstrate that host microbiota crosstalk plays a causal on the regulation of blood pressure, glucose metabolism and the development of atherosclerosis. Host microbiota crosstalk is associated in humans with main cardiovascular risk factors notably hypertension and type 2 diabetes. Host microbiota crosstalk is associated in humans with the onset of cardiovascular diseases...
June 13, 2018: La Presse Médicale
https://www.readbyqxmd.com/read/29909141/new-onset-diabetes-after-androgen-deprivation-therapy-for-prostate-cancer-a-nationwide-propensity-score-matched-four-year-longitudinal-cohort-study
#20
Jhen-Hao Jhan, Hsin-Chih Yeh, Yu-Han Chang, Shiao-Jin Guu, Wen-Jeng Wu, Yii-Her Chou, Ching-Chia Li
INTRODUCTION: Androgen-deprivation therapy (ADT) is important in the treatment of prostate cancer. However, the relationship between ADT and the risk of diabetes remains unclear, and the association between duration and types of ADT has not been fully investigated. AIM: To examine the risk of developing type 2 diabetes mellitus (T2DM) in men who underwent ADT for prostate cancer. METHODS: Data were collected retrospectively from the Longitudinal Health Insurance Database of Taiwan...
March 22, 2018: Journal of Diabetes and its Complications
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