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https://www.readbyqxmd.com/read/27863506/interleukin-37-limits-monosodium-urate-crystal-induced-innate-immune-responses-in-human-and-murine-models-of-gout
#1
Lei Liu, Yu Xue, Yingfeng Zhu, Dandan Xuan, Xue Yang, Minrui Liang, Juan Wang, Xiaoxia Zhu, Jiong Zhang, Hejian Zou
BACKGROUND: Interleukin (IL)-37 has emerged as a fundamental inhibitor of innate immunity. Acute gout is a self-limiting inflammatory response to monosodium urate (MSU) crystals. In the current study, we assessed the preventive and therapeutic effect of recombinant human IL-37 (rhIL-37) in human and murine gout models. METHODS: We investigated the expression of IL-37 in patients with active and inactive gouty arthritis and assessed the effect of rhIL-37 in human and murine gout models: a human monocyte cell line (THP-1) and human synovial cells (containing macrophage-like and fibroblast-like synoviocytes) exposed to MSU crystals, a peritoneal murine model of gout and a murine gouty arthritis model...
November 18, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27846260/alternatively-activated-m2-macrophage-phenotype-is-inducible-by-endothelin-1-in-cultured-human-macrophages
#2
Stefano Soldano, Carmen Pizzorni, Sabrina Paolino, Amelia Chiara Trombetta, Paola Montagna, Renata Brizzolara, Barbara Ruaro, Alberto Sulli, Maurizio Cutolo
BACKGROUND: Alternatively activated (M2) macrophages are phenotypically characterized by the expression of specific markers, mainly macrophage scavenger receptors (CD204 and CD163) and mannose receptor-1 (CD206), and participate in the fibrotic process by over-producing pro-fibrotic molecules, such as transforming growth factor-beta1 (TGFbeta1) and metalloproteinase (MMP)-9. Endothelin-1 (ET-1) is implicated in the fibrotic process, exerting its pro-fibrotic effects through the interaction with its receptors (ETA and ETB)...
2016: PloS One
https://www.readbyqxmd.com/read/27831589/the-anti-inflammatory-vasostatin-2-attenuates-atherosclerosis-in-apoe-mice-and-inhibits-monocyte-macrophage-recruitment
#3
Weixin Xiong, Xiaoqun Wang, Daopeng Dai, Bao Zhang, Lin Lu, Rong Tao
We showed previously that reduced level of vasostatin-2 (VS-2) correlates to the presence and severity of coronary artery disease. In this study, we aimed to figure out the role of chromogranin A (CGA) derived VS-2 in the development of atherosclerosis and monocyte/macrophage recruitment. Apolipoprotein E-deficient (ApoE(-/-)) mice fed a high-fat diet exhibited attenuated lesion size by 65 % and 41 % in En face and aortic root Oil red O staining, MOMA-2 positive area by 64 %, respectively, in VS-2 treatment group compared with PBS group...
November 10, 2016: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/27780575/expression-kinetics-of-rantes-and-mcp-1-in-the-brain-of-deer-mice-peromyscus-maniculatus-infected-with-vesicular-stomatitis-new-jersey-virus
#4
L P Mesquita, F R P Bruhn, P C Maiorka, E W Howerth
The vesicular stomatitis virus (VSV) causes encephalitis in mice when inoculated intranasally. The deer mouse (Peromyscus maniculatus), a native New World rodent, is also susceptible to VSV infection and develops similar central nervous system (CNS) lesions to those observed in other rodent species. Chemokines, such as regulated on activation, normal T-cell expressed and secreted (RANTES; CCL-5) and monocyte chemoattractant protein (MCP)-1 (CCL-2), which are important for chemotaxis and activation of inflammatory cells, are expressed during the course of VSV encephalitis...
November 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27723233/distinct-inflammatory-phenotypes-of-microglia-and-monocyte-derived-macrophages-in-alzheimer-s-disease-models-effects-of-aging-and-amyloid-pathology
#5
Elodie Martin, Céline Boucher, Bertrand Fontaine, Cécile Delarasse
Alzheimer's disease (AD) is a neurodegenerative disease characterized by formation of amyloid-β (Aβ) plaques, activated microglia, and neuronal cell death leading to progressive dementia. Recent data indicate that microglia and monocyte-derived macrophages (MDM) are key players in the initiation and progression of AD, yet their respective roles remain to be clarified. As AD occurs mostly in the elderly and aging impairs myeloid functions, we addressed the inflammatory profile of microglia and MDM during aging in TgAPP/PS1 and TgAPP/PS1dE9, two transgenic AD mouse models, compared to WT littermates...
October 8, 2016: Aging Cell
https://www.readbyqxmd.com/read/27664471/death-receptor-3-promotes-chemokine-directed-leukocyte-recruitment-in-acute-resolving-inflammation-and-is-essential-for-pathological-development-of-mesothelial-fibrosis-in-chronic-disease
#6
William V Perks, Ravinder K Singh, Gareth W Jones, Jason P Twohig, Anwen S Williams, Ian R Humphreys, Philip R Taylor, Simon A Jones, Eddie C Y Wang
Death receptor 3 (DR3; TNFRSF25) and its tumor necrosis factor-like ligand TL1A (TNFSF15) control several processes in inflammatory diseases through the expansion of effector T cells and the induction of proinflammatory cytokines from myeloid and innate lymphoid cells. Using wild-type (DR3(+/+)) and DR3-knockout (DR3(-/-)) mice, we show that the DR3/TL1A pathway triggers the release of multiple chemokines after acute peritoneal inflammation initiated by a single application of Staphylococcus epidermidis supernatant, correlating with the infiltration of multiple leukocyte subsets...
November 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/27396406/elevations-in-the-levels-of-nf-%C3%AE%C2%BAb-and-inflammatory-chemotactic-factors-in-the-brains-with-alzheimer-s-disease-one-mechanism-may-involve-%C3%AE-3-nicotinic-acetylcholine-receptor
#7
Yuan Liao, Xiao-Lan Qi, Ying Cao, Wen-Feng Yu, Rivka Ravid, Bengt Winblad, Jin-Jing Pei, Zhi-Zhong Guan
The purpose of this study was to investigate the alterations in the levels of nuclear factor κBp65 (NF-κBp65), monocyte chemoattractant protein 1 (MCP-1/CCL-2) and macrophage inflammatory protein 1α (MIP-1α/CCL-3) in relationship to the expression of α3 nicotinic acetylcholine receptor (nAChR) during the pathogenesis of Alzheimer's disease (AD). The post-mortem human brains of AD and age-matched control individuals, SH-SY5Y and U87MG cell lines exposed to β-amyloid peptide (Aβ), as well as the SH-SY5Y cells in which α3 nAChR was down-regulated by siRNA were used to study the possible expression changes of the targets such as NF-κBp65, MCP-1, MIP-1α and α3 nAChR...
July 3, 2016: Current Alzheimer Research
https://www.readbyqxmd.com/read/27340563/lecithin-bound-iodine-prevents-disruption-of-tight-junctions-of-retinal-pigment-epithelial-cells-under-hypoxic-stress
#8
Masahiko Sugimoto, Mineo Kondo
Aim. We investigated whether lecithin-bound iodine (LBI) can protect the integrity of tight junctions of retinal pigment epithelial cells from hypoxia. Method. Cultured human retinal pigment epithelial (ARPE-19) cells were pretreated with LBI. To mimic hypoxic conditions, cells were incubated with CoCl2. We compared the integrity of the tight junctions (TJs) of control to cells with either LBI alone, CoCl2 alone, or LBI + CoCl2. The levels of cytokines in the conditioned media were also determined. Results...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27231721/high-salt-induces-anti-inflammatory-m%C3%AE-2-like-phenotype-in-peripheral-macrophages
#9
Suneetha Amara, Margaret Whalen, Venkataswarup Tiriveedhi
Macrophages play a critical role in inflammation and antigen-presentation. Abnormal macrophage function has been attributed in autoimmune diseases and cancer progression. Recent evidence suggests that high salt tissue micro-environment causes changes in macrophage activation. In our current report, we studied the role of extracellular sodium chloride on phenotype changes in peripheral circulating monocyte/macrophages collected from healthy donors. High salt (0.2 M NaCl vs basal 0.1 M NaCl) treatment resulted in a decrease in MΦ1 macrophage phenotype (CD11b(+)CD14(high)CD16(low)) from 77...
September 2016: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/27226520/monocyte-exosomes-induce-adhesion-molecules-and-cytokines-via-activation-of-nf-%C3%AE%C2%BAb-in-endothelial-cells
#10
Norina Tang, Bing Sun, Archana Gupta, Hans Rempel, Lynn Pulliam
HIV-infected individuals have activated monocytes with an IFNα phenotype and elevated levels of circulating LPS. These individuals also have a risk of premature cardiovascular disease. The effect of activated monocyte exosomes (Exos) on endothelial cells is unknown. To determine whether Exos from immune-activated monocytes could alter endothelial cell expression and contribute to monocyte/macrophage transmigration and adhesion, we isolated Exos from monocytes stimulated with IFNα, LPS, or both (I/L). We show that monocyte Exos contain different inflammatory microRNA cargo depending on stimulation...
September 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27135421/age-associated-vascular-inflammation-promotes-monocytosis-during-atherogenesis
#11
Wei Du, Christine Wong, Yang Song, Hua Shen, Daniel Mori, Noemi Rotllan, Nathan Price, Anca D Dobrian, Hailong Meng, Steven H Kleinstein, Carlos Fernandez-Hernando, Daniel R Goldstein
Aging leads to a proinflammatory state within the vasculature without disease, yet whether this inflammatory state occurs during atherogenesis remains unclear. Here, we examined how aging impacts atherosclerosis using Ldlr(-/-) mice, an established murine model of atherosclerosis. We found that aged atherosclerotic Ldlr(-/-) mice exhibited enhanced atherogenesis within the aorta. Aging also led to increased LDL levels, elevated blood pressure on a low-fat diet, and insulin resistance after a high-fat diet (HFD)...
August 2016: Aging Cell
https://www.readbyqxmd.com/read/27072064/novel-piperazine-core-compound-induces-death-in-human-liver-cancer-cells-possible-pharmacological-properties
#12
Nima Samie, Sekaran Muniandy, M S Kanthimathi, Batoul Sadat Haerian, Raja Elina Raja Azudin
The current study evaluates the cytotoxic mechanism of a novel piperazine derivate designated as PCC against human liver cancer cells. In this context, human liver cancer cell lines, SNU-475 and 243, human monocyte/macrophage cell line, CRL-9855, and human B lymphocyte cell line, CCL-156, were used to determine the IC50 of PCC using the standard MTT assay. PCC displayed a strong suppressive effect on SNU-475 and SNU-423 cells with an IC50 value of 6.98 ± 0.11 μg/ml and 7.76 ± 0.45 μg/ml respectively, after 24 h of treatment...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26965295/enhanced-monocyte-migration-to-cxcr3-and-ccr5-chemokines-in-copd
#13
Claudia Costa, Suzanne L Traves, Susan J Tudhope, Peter S Fenwick, Kylie B R Belchamber, Richard E K Russell, Peter J Barnes, Louise E Donnelly
Chronic obstructive pulmonary disease (COPD) patients exhibit chronic inflammation, both in the lung parenchyma and the airways, which is characterised by an increased infiltration of macrophages and T-lymphocytes, particularly CD8+ cells. Both cell types can express chemokine (C-X-C motif) receptor (CXCR)3 and C-C chemokine receptor 5 and the relevant chemokines for these receptors are elevated in COPD. The aim of this study was to compare chemotactic responses of lymphocytes and monocytes of nonsmokers, smokers and COPD patients towards CXCR3 ligands and chemokine (C-C motif) ligand (CCL)5...
April 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/26883191/ccl-34-a-synthetic-toll-like-receptor-4-activator-modulates-differentiation-and-maturation-of-myeloid-dendritic-cells
#14
Shu-Ling Fu, Chun-Cheng Lin, Ming-Ling Hsu, Sheng-Hung Liu, Yu-Chuen Huang, Yu-Jen Chen
CCL-34, a synthetic α-galactosylceramide analog, has been reported as an activator of toll-like receptor 4 (TLR4) in macrophages. TLR4 is highly expressed in dendritic cell (DC) and several TLR4 agonists are known to trigger DC maturation. We herein evaluated the effect of CCL-34 on DC maturation. Human CD14+ monocyte-derived immature DC were treated with CCL-34, its inactive structural analog CCL-44, or LPS to assess the DC maturation. CCL-34 induced DC maturation according to their characteristically dendrite-forming morphology, CD83 expression and IL-12p70 production...
March 8, 2016: Oncotarget
https://www.readbyqxmd.com/read/26872986/ambroxol-inhalation-ameliorates-lps-induced-airway-inflammation-and-mucus-secretion-through-the-extracellular-signal-regulated-kinase-1-2-signaling-pathway
#15
Shui-juan Zhang, Juan-xia Jiang, Qian-qian Ren, Yong-liang Jia, Jian Shen, Hui-juan Shen, Xi-xi Lin, Hong Lu, Qiang-min Xie
Ambroxol, a metabolite of bromhexine, is shown to exert several pharmacological activities, including secretolytic, anti-inflammatory and antioxidant actions. Oral and intravenous administration of ambroxol is useful for the airway inflammatory diseases. However, little is known about its potential in inhalation therapy for lipopolysaccharide (LPS)-induced mucous hypersecretion and inflammatory response. In the present study, we compared the pharmacological effects of ambroxol by inhalation with intravenous administration and preliminarily explored its mechanism of action...
March 15, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/26499899/elevated-circulating-monocyte-chemoattractant-protein-1-mcp-1-ccl-2-level-may-be-an-unfavorable-predictive-factor-to-platinum-and-taxane-based-combination-chemotherapy-in-patients-with-gastric-cancer
#16
Faruk Tas, Senem Karabulut, Murat Serilmez, Mehmet Karabulut, Derya Duranyildiz
PURPOSE: Monocyte chemoattractant protein 1 (MCP-1/CCL-2) is a member of the CC chemokine family and a potent chemotactic factor for monocytes that regulate migration and infiltration of monocytes and macrophages. It plays an important role in the pathogenesis of multiple malignancies, and its expression strongly also affects the outcomes of cancer patients. The objective of this study was to determine the clinical significance of the serum levels of MCP-1/CCL-2 in gastric cancer patients...
January 2016: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/26474621/-molecular-mechanism-involved-in-adhesion-of-monocytes-to-endothelial-cells-induced-by-nicotine-and-porphyromonas-gingivalis-lps
#17
Yi-xiang Wang, Na An, Xiang-ying Ouyang
OBJECTIVE: To investigate molecular mechanism involved in nicotine in combination with Porphyromonas gingivalis (P.g) caused monocyte-endothelial cell adhesion. METHODS: The effect of nicotine, P.g-lipopolysaccharide (P.g-LPS) and their combination on the proliferation of U937 cells was determined by CCK-8 method. Interleukin-6 (IL-6) expression was investigated by real-time PCR after U937 cells were treated with nicotine, P.g-LPS and their combination. In human umbilical vein endothelial cells (HUVECs), the expressions of monocyte chemoattractant protein CCL-8 and adhesion molecules including vascular cell adhesion molecule 1 (Vcam-1), very late antigen 4 alpha (VLA4α), tumor necrosis factor receptor superfamily member 4 (OX40) and OX40 ligand (OX40L) were detected by real-time PCR or Western blotting assays after HUVEC cells were treated with nicotine, P...
October 18, 2015: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/26407613/umbilical-cord-blood-derived-cd11c-dendritic-cells-could-serve-as-an-alternative-allogeneic-source-of-dendritic-cells-for-cancer-immunotherapy
#18
Jeetendra Kumar, Vaijayanti Kale, Lalita Limaye
INTRODUCTION: Allogenic dendritic cells (DCs) generated from healthy donors, who are complete or partially HLA-matched, have been used for clinical trials. One of the sources for allogenic DCs is umbilical cord blood (UCB) cells. However, as far as cord blood cells are concerned, looking at their naïve nature, there is a concern as to whether the DCs generated from them will have enough potential to elicit a proper T cell response. For this, we compared CD11c(+) UCB-DCs/ Cytotoxic T lymphocytes (CTLs) with the conventional source, i...
2015: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/26305254/apple-polyphenols-decrease-atherosclerosis-and-hepatic-steatosis-in-apoe-mice-through-the-ros-mapk-nf-%C3%AE%C2%BAb-pathway
#19
Zhe-Rong Xu, Jin-You Li, Xin-Wei Dong, Zhong-Ju Tan, Wei-Zhen Wu, Qiang-Min Xie, Yun-Mei Yang
In this study, we examined the effects of apple polyphenols (APs) on hyperlipidemia, atherosclerosis, hepatic steatosis and endothelial function and investigated the potential mechanisms. ApoE(-/-) mice were fed a western-type diet and orally treated with APs (100 mg/kg) or atorvastatin (10 mg/kg) for 12 weeks. Hyperlipidemia and atherosclerosis in the aortic sinuses and, and hepatic lipidosis were measured. The treatment with APs or atorvastatin induced a remarkable reduction in the atherosclerotic lesions and hepatic steatosis and decreased the levels of low-density lipoprotein, triglyceride, CCL-2 and VCAM-1 levels in the plasma...
August 2015: Nutrients
https://www.readbyqxmd.com/read/26169275/genetically-modified-live-attenuated-leishmania-donovani-parasites-induce-innate-immunity-through-classical-activation-of-macrophages-that-direct-the-th1-response-in-mice
#20
Parna Bhattacharya, Ranadhir Dey, Pradeep K Dagur, Michael Kruhlak, Nevien Ismail, Alain Debrabant, Amritanshu B Joshi, Adovi Akue, Mark Kukuruga, Kazuyo Takeda, Angamuthu Selvapandiyan, John Philip McCoy, Hira L Nakhasi
Visceral leishmaniasis (VL) causes significant mortality and there is no effective vaccine. Previously, we have shown that genetically modified Leishmania donovani parasites, here described as live attenuated parasites, induce a host protective adaptive immune response in various animal models. In this study, we demonstrate an innate immune response upon infection with live attenuated parasites in macrophages from BALB/c mice both in vitro and in vivo. In vitro infection of macrophages with live attenuated parasites (compared to that with wild-type [WT] L...
October 2015: Infection and Immunity
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