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https://www.readbyqxmd.com/read/29691783/optimization-of-fixative-solution-for-retinal-morphology-a-comparison-with-davidson-s-fixative-and-other-fixation-solutions
#1
Kazuhiro Tokuda, Byron Baron, Yasuhiro Kuramitsu, Takao Kitagawa, Nobuko Tokuda, Naoyuki Morishige, Masaaki Kobayashi, Kazuhiro Kimura, Kazuyuki Nakamura, Koh-Hei Sonoda
PURPOSE: Numerous fixative solutions are available but many are not amenable to the histomorphological preservation of retinae. The investigators specifically focused on retinal histological studies, which rather than 4% formaldehyde (FA), often use Davidson's fixative. However the latter has its limitations. The purpose of this study was to produce a new fixative which maintains retinae closer to the in vivo conditions. STUDY DESIGN: Experimental design. METHODS: Four fixative formulations (4% paraformaldehyde, Davidson's fixative, modified Davidson's fixative and an in-house fixative - TB-Fix) were tested on retinae and the outcomes on histomorphology and immunohistochemical staining for selected antigenic markers was compared...
April 24, 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29691212/utilization-of-a-clinical-trial-management-system-for-the-whole-clinical-trial-process-as-an-integrated-database-system-development
#2
Yu Rang Park, Young Jo Yoon, HaYeong Koo, Soyoung Yoo, Chang-Min Choi, Sung-Ho Beck, Tae Won Kim
BACKGROUND: Clinical trials pose potential risks in both communications and management due to the various stakeholders involved when performing clinical trials. The academic medical center has a responsibility and obligation to conduct and manage clinical trials while maintaining a sufficiently high level of quality, therefore it is necessary to build an information technology system to support standardized clinical trial processes and comply with relevant regulations. OBJECTIVE: The objective of the study was to address the challenges identified while performing clinical trials at an academic medical center, Asan Medical Center (AMC) in Korea, by developing and utilizing a clinical trial management system (CTMS) that complies with standardized processes from multiple departments or units, controlled vocabularies, security, and privacy regulations...
April 24, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29690476/identification-of-type-materials-of-the-species-of-protypotherium-ameghino-1885-and-patriarchus-ameghino-1889-notoungulata-interatheriidae-erected-by-florentino-ameghino
#3
Mercedes FernÁndez, Juan Carlos Fernicola, Esperanza CerdeÑo, Marcelo A Reguero
The first collections of Interatheriinae (Interatheriidae, Notoungulata) were created by the brothers Florentino and Carlos Ameghino, based on fossil specimens collected from diverse outcrops of Argentina and housed at different national institutions. In order to perform a systematic study of the subfamily, it is essential to revise as much specimens as possible, but first of all those that were used to establish the respective species, that is, the type material. Florentino Ameghino never referred to the collection number of the type specimens of the species he erected in any of his publications; this fact added to the occasional absence of illustrations and adequate descriptions, all of which make their identification a complex task...
February 27, 2018: Zootaxa
https://www.readbyqxmd.com/read/29690388/taxonomic-clarification-and-neotype-designation-for-three-indian-xyleborine-species-coleoptera-curculionidae-scolytinae
#4
Sarah M Smith, Roger A Beaver, Sudhir Singh, Anthony I Cognato
Xyleborini currently consists of more than 1168 species in 36 genera, nearly all of which were described in Xyleborus (Hulcr et al. 2015; Smith 2017). The tribe has been the focus of considerable taxonomic attention over the last decade resulting in phylogenetically based revisions and the erection of new genera (e.g. Hulcr et al. 2007, Hulcr and Cognato 2010). However in the Old World these efforts have largely been restricted to faunas of particular countries such as Taiwan (Beaver and Liu 2010), Thailand (Beaver et al...
March 12, 2018: Zootaxa
https://www.readbyqxmd.com/read/29687480/review-of-atrazine-sampling-by-pocis-and-chemcatcher
#5
REVIEW
Kees Booij, Sunmao Chen
A key success factor for the performance of passive samplers is the proper calibration of sampling rates. Sampling rates for a wide range of polar organic compounds are available for Chemcatchers and polar organic chemical integrative samplers (POCIS), but the mechanistic models that are needed to understand the effects of exposure conditions on sampling rates need improvement. Literature data on atrazine sampling rates by these samplers were reviewed with the aim to assess what can be learned from literature reports of this well studied compound and to identify knowledge gaps related to the effects of flow and temperature...
April 24, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29683840/enhancing-hiv-pre-exposure-prophylaxis-practices-via-an-educational-intervention
#6
Rebecca Newman, Tasleem Katchi, Michael Karass, Melissa Gennarelli, Jason Goutis, Alina Kifayat, Shantanu Solanki, Srikanth Yandrapalli, Leanne Forman, Christopher Nabors
BACKGROUND: Pre-exposure prophylaxis (PrEP) for HIV involves using antiretroviral drugs to prevent individuals at high risk from acquiring HIV infection. Most practicing primary care providers believe PrEP to be safe and effective, but less than half have prescribed or referred for PrEP. Attitudes and prescribing patterns among house officers have not been well described previously. STUDY QUESTION: Can an educational intervention enhance HIV PrEP practices among internal medicine house officers? STUDY DESIGN: This study relied on a pretest/posttest design...
April 20, 2018: American Journal of Therapeutics
https://www.readbyqxmd.com/read/29683785/association-study-of-cacna1c-polymorphisms-with-large-artery-atherosclerotic-stroke-in-chinese-han-population
#7
Chen Peng, Ying Ding, Xin Yi, Zhiqiang Dong, Limei Cao, Qiang Li, Haiyan Ren, Lin He, Daizhan Zhou, Xu Chen
Aims Ischemic stroke (IS) is one of the most common diseases of neurology and the main cause of death and disability in Chinese population. CACNA1C was considered to be involved in the process of atherosclerosis, but there was little information about the association between genotypic polymorphisms of CACNA1C and ischemic stroke. Our study was designed to elucidate the relationship between four single-nucleotide polymorphisms (SNPs) variants in CACNA1C gene and the risk of large-artery atherosclerotic (LAA) stroke patients...
April 23, 2018: Neurological Research
https://www.readbyqxmd.com/read/29680934/making-the-connection-using-videoconferencing-to-increase-linkage-to-care-for-incarcerated-persons-living-with-hiv-post-release
#8
Antoine D Brantley, Karissa M Page, Barry Zack, Kira Radtke Friedrich, Deborah Wendell, William T Robinson, DeAnn Gruber
Incarcerated persons living with HIV (PLWH) have relatively high levels of HIV care engagement and antiretroviral therapy adherence during incarceration, but few are able to maintain these levels upon reentry into the community. In Louisiana, PLWH nearing release from prisons were offered video conferences with case managers housed in community based organizations aimed at facilitating linkage to care in the community. Of the 144 persons who received a video conference during the study period, 74.3% had linked to HIV care in the community within 90 days after release...
April 21, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29678128/spirpep-an-in-silico-digestion-based-platform-to-assist-bioactive-peptides-discovery-from-a-genome-wide-database
#9
Krittima Anekthanakul, Apiradee Hongsthong, Jittisak Senachak, Marasri Ruengjitchatchawalya
BACKGROUND: Bioactive peptides, including biological sources-derived peptides with different biological activities, are protein fragments that influence the functions or conditions of organisms, in particular humans and animals. Conventional methods of identifying bioactive peptides are time-consuming and costly. To quicken the processes, several bioinformatics tools are recently used to facilitate screening of the potential peptides prior their activity assessment in vitro and/or in vivo...
April 20, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29677705/in-house-validation-and-small-scale-collaborative-study-to-evaluate-analytical-performances-of-multi-mycotoxin-screening-methods-based-on-liquid-chromatography-high-resolution-mass-spectrometry-case-study-fusarium-toxins-in-wheat
#10
Biancamaria Ciasca, Michelangelo Pascale, Valerio Guido Altieri, Francesco Longobardi, Michele Suman, Dante Catellani, Veronica M T Lattanzio
A strong trend toward using highly selective mass spectrometry technologies for screening of multiple mycotoxins has been observed in recent years. In the present study, the process of validation of a multi-mycotoxin screening method based on liquid chromatography high-resolution mass spectrometry method is presented. The method was intended for the simultaneous screening of the major Fusarium toxins (deoxynivalenol, 3- and 15-acetyl deoxynivalenol, T-2 and HT-2 toxins, zearalenone, enniatins A, A1, B, B1, beauvericin) in wheat...
April 20, 2018: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/29676805/concurrent-determination-and-separation-of-inorganic-cations-and-anions-in-microchip-electrophoresis-with-precisely-controlled-high-voltage
#11
Zhe Huang, Mingpeng Yang, Hui You, Yang Xie
An improved method for the concurrent determination and separation of cations and anions by microchip electrophoresis with capacitively coupled contactless conductivity detection (ME-C4 D) is described. Two kinds of microchip structures were designed. The first microchip has a long bent separation channel. And for the defects of the first microchip, the second microchip with a Y-type separation channel has been proposed. The background electrolyte (BGE) composed of 20 mm His/MES and 0.01 mm CTAB was optimized for inhibiting the electroosmotic flow (EOF)...
April 20, 2018: Electrophoresis
https://www.readbyqxmd.com/read/29676071/differences-in-genetic-variations-between-treatable-and-recalcitrant-atopic-dermatitis-in-korean
#12
Myungsoo Jun, Hye Young Wang, Solam Lee, Eunhee Choi, Hyeyoung Lee, Eung Ho Choi
PURPOSE: Variations in barrier- or immune response-related genes are closely related to the development of atopic dermatitis (AD). This study was designed to identify genetic variations and clinical features to predict 'recalcitrant AD.' METHODS: AD patients were classified as treatable and recalcitrant. Treatable AD patients showed satisfactory clinical improvement with basic and topical treatments. Recalcitrant AD patients used systemic immune-suppressants for over 4 weeks as they had not shown clinical improvement with basic and topical treatments...
May 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29674309/measuring-risky-driving-behavior-using-an-mhealth-smartphone-app-development-and-evaluation-of-gforce
#13
Raisa Z Freidlin, Amisha D Dave, Benjamin G Espey, Sean T Stanley, Marcial A Garmendia, Randall Pursley, Johnathon P Ehsani, Bruce G Simons-Morton, Thomas J Pohida
BACKGROUND: Naturalistic driving studies, designed to objectively assess driving behavior and outcomes, are conducted by equipping vehicles with dedicated instrumentation (eg, accelerometers, gyroscopes, Global Positioning System, and cameras) that provide continuous recording of acceleration, location, videos, and still images for eventual retrieval and analyses. However, this research is limited by several factors: the cost of equipment installation; management and storage of the large amounts of data collected; and data reduction, coding, and analyses...
April 19, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29672327/the-affordable-care-act-decreased-the-proportion-of-uninsured-patients-in-a-safety-net-orthopaedic-clinic
#14
Joseph A Gil, Avi D Goodman, Justin Kleiner, Robin N Kamal, Laurence C Baker, Edward Akelman
BACKGROUND: The Patient Protection and Affordable Care Act (ACA) was approved in 2010, substantially altering the economics of providing and receiving healthcare services in the United States. One of the primary goals of this legislation was to expand insurance coverage for under- and uninsured residents. Our objective was to examine the effect of the ACA on the insurance status of patients at a safety net clinic. Our institution houses a safety net clinic that provides the dominant majority of orthopaedic care for uninsured patients in our state...
May 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29672197/inflammasomes-make-the-case-for-littermate-controlled-experimental-design-in-studying-host-microbiota-interactions
#15
Michail Mamantopoulos, Francesca Ronchi, Kathy D McCoy, Andy Wullaert
Several human diseases are thought to evolve due to a combination of host genetic mutations and environmental factors that include alterations in intestinal microbiota composition termed dysbiosis. Although in some cases, host genetics may shape the gut microbiota and enable it to provoke disease, experimentally disentangling cause and consequence in such host-microbe interactions requires strict control over non-genetic confounding factors. Mouse genetic studies previously proposed Nlrp6/ASC inflammasomes as innate immunity regulators of the intestinal ecosystem...
April 19, 2018: Gut Microbes
https://www.readbyqxmd.com/read/29670340/the-design-and-evaluation-of-psychometric-properties-for-a-questionnaire-on-elderly-abuse-by-family-caregivers-among-older-adults-on-hemodialysis
#16
Amaneh Mahmoudian, Razieh Torabi Chafjiri, Atefeh Alipour, Abbas Shamsalinia, Fatemeh Ghaffari
Introduction: Older adults with chronic disease are more vulnerable to abuse. Early and accurate detection of the elderly abuse phenomenon can help identify health-promoting solutions for the elderly, their family, and society. The purpose of this study was to design and evaluate the psychometric properties of a questionnaire on elderly abuse by family caregivers among older adults on hemodialysis. Methods: Qualitative and quantitative research methodologies were used to develop the questionnaire...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29668956/metagenome-and-culture-based-methods-reveal-candidate-bacterial-mutualists-in-the-southern-house-mosquito-diptera-culicidae
#17
Aparna Telang, Jessica Skinner, Robert Z Nemitz, Alexander M McClure
Mosquitoes are intensely studied as vectors of disease-causing pathogens, but we know relatively less about microbes that naturally reside in mosquitoes. Profiling resident bacteria in mosquitoes can help identify bacterial groups that can be exploited as a strategy of controlling mosquito populations. High-throughput 16S rRNA gene sequencing and traditional culture-based methods were used to identify bacterial assemblages in Culex quinquefasciatus Say (Diptera: Culicidae) in a tissue- and stage-specific design...
April 16, 2018: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29668940/determination-of-net-energy-content-of-dietary-lipids-fed-to-growing-pigs-using-indirect-calorimetry
#18
E K Li, H Liu, Y K Li, L Liu, F L Wang, D F Li, S Zhang
The objective of this experiment was to determine the NE content of different dietary lipids fed to growing pigs using indirect calorimetry. Thirty-six growing (initial BW: 41.1 ± 3.1 kg) barrows were allotted to six diets based on completely randomized design with 6 replicate pigs per diet. Diets included a corn-soybean meal basal diet and 5 test diets each containing 10% palm oil, poultry fat, fish oil, corn oil or flaxseed oil at the expense of corn and soybean meal. During each period, pigs were individually housed in metabolism crates for 14 days, which included 7 days for adaptation to feed, metabolism crates and environmental conditions...
April 13, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29665018/differential-response-of-human-dermal-fibroblast-subpopulations-to-visible-and-near-infrared-light-potential-of-photobiomodulation-for-addressing-cutaneous-conditions
#19
Charles Mignon, Natallia E Uzunbajakava, Irene Castellano-Pellicena, Natalia V Botchkareva, Desmond J Tobin
BACKGROUND OBJECTIVES: The past decade has witnessed a rapid expansion of photobiomodulation (PBM), demonstrating encouraging results for the treatment of cutaneous disorders. Confidence in this approach, however, is impaired not only by a lack of understanding of the light-triggered molecular cascades but also by the significant inconsistency in published experimental outcomes, design of the studies and applied optical parameters. This study aimed at characterizing the response of human dermal fibroblast subpopulations to visible and near-infrared (NIR) light in an attempt to identify the optical treatment parameters with high potential to address deficits in aging skin and non-healing chronic wounds...
April 17, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29663938/cohousing-male-mice-with-and-without-segmental-bone-defects
#20
Jeffrey D Rytlewski, Paul J Childress, David C Scofield, Faisal Khan, Marta B Alvarez, Aamir T Tucker, Jonathan S Harris, Jessica L Peveler, Debra L Hickman, Tien-Min G Chu, Melissa A Kacena
Spaceflight results in bone loss like that associated with osteoporosis or decreased weight-bearing (for example, high-energy trauma such as explosive injuries and automobile accidents). Thus, the unique spaceflight laboratory on the International Space Station presents the opportunity to test bone healing agents during weightlessness. We are collaborating with NASA and the US Army to study bone healing in spaceflight. Given the unique constraints of spaceflight, study design optimization was required. Male mice were selected primarily because their femur is larger than females', allowing for more reproducible surgical outcomes...
April 2, 2018: Comparative Medicine
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