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https://www.readbyqxmd.com/read/27922886/bioengineered-renal-cell-therapy-device-for-clinical-translation
#1
Christopher J Pino, Angela J Westover, Deborah A Buffington, H David Humes
The Bioartificial Renal Epithelial Cell System (BRECS), is a cell-based device to treat acute kidney injury through renal cell therapy from an extracorporeal circuit. To enable widespread implementation of cell therapy, the BRECS was designed to be cryopreserved as a complete device, cryostored, cryoshipped to an end-use site, thawed as a complete device, and employed in a therapeutic extracorporeal hemofiltration circuit. This strategy overcomes storage and distribution issues that have been previous barriers to cell therapy...
December 2, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27920726/hrvanalysis-a-free-software-for-analyzing-cardiac-autonomic-activity
#2
Vincent Pichot, Frédéric Roche, Sébastien Celle, Jean-Claude Barthélémy, Florian Chouchou
Since the pioneering studies of the 1960s, heart rate variability (HRV) has become an increasingly used non-invasive tool for examining cardiac autonomic functions and dysfunctions in various populations and conditions. Many calculation methods have been developed to address these issues, each with their strengths and weaknesses. Although, its interpretation may remain difficult, this technique provides, from a non-invasive approach, reliable physiological information that was previously inaccessible, in many fields including death and health prediction, training and overtraining, cardiac and respiratory rehabilitation, sleep-disordered breathing, large cohort follow-ups, children's autonomic status, anesthesia, or neurophysiological studies...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27917874/discovery-synthesis-biological-evaluation-and-structure-based-optimization-of-novel-piperidine-derivatives-as-acetylcholine-binding-protein-ligands
#3
Jian Shen, Xi-Cheng Yang, Ming-Cheng Yu, Li Xiao, Xun-Jie Zhang, Hui-Jiao Sun, Hao Chen, Guan-Xin Pan, Yu-Rong Yan, Si-Chen Wang, Wei Li, Lu Zhou, Qiong Xie, Lin-Qian Yu, Yong-Hui Wang, Li-Ming Shao
The homomeric α7 nicotinic receptor (α7 nAChR) is widely expressed in the human brain that could be activated to suppress neuroinflammation, oxidative stress and neuropathic pain. Consequently, a number of α7 nAChR agonists have entered clinical trials as anti-Alzheimer's or anti-psychotic therapies. However, high-resolution crystal structure of the full-length α7 receptor is thus far unavailable. Since acetylcholine-binding protein (AChBP) from Lymnaea stagnalis is most closely related to the α-subunit of nAChRs, it has been used as a template for the N-terminal domain of α-subunit of nAChR to study the molecular recognition process of nAChR-ligand interactions, and to identify ligands with potential nAChR-like activities...
December 5, 2016: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/27914517/effect-of-flaxseed-oil-and-microalgae-dha-on-the-production-performance-fatty-acids-and-total-lipids-of-egg-yolk-and-plasma-in-laying-hens
#4
M Neijat, O Ojekudo, J D House
The incorporation of omega-3 polyunsaturated fatty acids (PUFA) in the egg is dependent on both the transfer efficiency of preformed dietary omega-3 fatty acids to the eggs as well as endogenous PUFA metabolism and deposition. Employing an experimental design consisting of 70 Lohmann LSL-Classic hens (n=10/treatment) in a 6-week feeding trial, we examined the impact of graded levels of either flaxseed oil (alpha-linolenic acid, ALA) or algal DHA (preformed docosahexaenoic acid, DHA), each supplying 0.20%, 0...
December 2016: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/27914401/examining-the-effects-of-microstructure-on-geoacoustic-parameters-in-fine-grained-sediments
#5
Megan S Ballard, Kevin M Lee
This paper presents a set of controlled laboratory experiments designed to develop a basis for understanding the relationship between microscopic and macroscopic properties of fine-grained sediments. Two samples of kaolinite platelets were selected for this study, and effects of sediment microstructure on geoacoustic properties are deduced from a comparison of the measured properties. To provide additional interpretation of the acoustic measurements, compressional and shear wave properties are compared to predicted values from sediment-acoustic models...
September 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27910419/design-and-fabrication-of-a-window-for-the-gas-cherenkov-detector-3
#6
V E Fatherley, D A Bingham, M D Cartelli, R A DiDomizio, J R Griego, H W Herrmann, F E Lopez, J A Oertel, M J Pollack
The gas Cherenkov detector 3 was designed at Los Alamos National Laboratory for use in inertial confinement fusion experiments at both the Omega Laser Facility and the National Ignition Facility. This instrument uses a low-Z gamma-to-electron convertor plate and high pressure gas to convert MeV gammas into UV/visible Cherenkov photons for fast optical detection. This is a follow-on diagnostic from previous versions, with two notable differences: the pressure of the gas is four times higher, and it allows the use of fluorinated gas, requiring metal seals...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910351/calibration-of-the-ohrex-high-resolution-imaging-crystal-spectrometer-at-the-livermore-electron-beam-ion-traps
#7
N Hell, P Beiersdorfer, E W Magee, G V Brown
We report the calibration of the Orion High-Resolution X-ray (OHREX) imaging crystal spectrometer at the EBIT-I electron beam ion trap at Livermore. Two such instruments, dubbed OHREX-1 and OHREX-2, are fielded for plasma diagnostics at the Orion laser facility in the United Kingdom. The OHREX spectrometer can simultaneously house two spherically bent crystals with a radius of curvature of r = 67.2 cm. The focusing properties of the spectrometer allow both for larger distance to the source due to the increase in collected light and for observation of extended sources...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27903266/environmental-determinants-of-malaria-transmission-in-african-villages
#8
Noriko Endo, Elfatih A B Eltahir
BACKGROUND: Malaria transmission is complex, involving a range of hydroclimatological, biological, and environmental processes. The high degree of non-linearity in these processes makes it difficult to predict and intervene against malaria. This study seeks both to define a minimal number of malaria transmission determinants, and to provide a theoretical basis for sustainable environmental manipulation to prevent malaria transmission. METHODS: Using a field-tested mechanistic malaria model, HYDREMATS, a theoretical study was conducted under hypothetical conditions...
December 1, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27902884/synthesis-and-biological-evaluation-of-new-triazolo-and-imidazolopyridine-ror%C3%AE-t-inverse-agonists
#9
Samuel Hintermann, Christine Guntermann, Henri Mattes, David A Carcache, Juergen Wagner, Anna Vulpetti, Andreas Billich, Janet Dawson, Klemens Kaupmann, Joerg Kallen, Rowan Stringer, David Orain
Retinoic-acid-related orphan receptor γt (RORγt) is a key transcription factor implicated in the production of pro-inflammatory Th17 cytokines, which drive a number of autoimmune diseases. Despite diverse chemical series having been reported, combining high potency with a good physicochemical profile has been a very challenging task in the RORγt inhibitor field. Based on available chemical structures and incorporating in-house knowledge, a new series of triazolo- and imidazopyridine RORγt inverse agonists was designed...
November 30, 2016: ChemMedChem
https://www.readbyqxmd.com/read/27900616/-the-apartment-is-for-you-it-s-not-for-anyone-else-managing-social-recovery-and-risk-on-the-frontlines-of-single-adult-supportive-housing
#10
Emmy Tiderington
This multi-method qualitative study examines frontline provider perspectives on consumer social relationships and barriers to social recovery in supportive housing programs for adults with serious mental illness. Thematic analyses show that guest and occupancy policies that enforce the "single" nature of single-adult supportive housing challenge consumer rights to self-determination in the realm of social recovery. Findings also highlight the ways in which providers act to reinforce and subvert these policies while mitigating risk in this service setting...
November 30, 2016: Administration and Policy in Mental Health
https://www.readbyqxmd.com/read/27898972/intake-digestibility-performance-and-nitrogen-metabolism-of-feedlot-finished-young-bulls-fed-diets-containing-peanut-cake
#11
B R Correia, G G P de Carvalho, R L Oliveira, A J V Pires, O L Ribeiro, R R Silva, A G Leão, P A Oliveira
This aim of this study was to evaluate the use of peanut cake as a dietary substitute for soybean meal and to determine the effects on intake, apparent digestibility, performance, and N metabolism in feedlot-finished young bulls. Thirty-two young Nellore bulls with an average initial BW of 390 ± 43.5 kg were distributed in a completely randomized design and individually housed in stalls. The young bulls were fed Tifton 85 hay and 4 concentrate mixes containing 0, 33, 66, or 100% peanut cake replacing soybean meal...
November 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27898938/effects-of-varying-floor-space-on-aggressive-behavior-and-cortisol-concentrations-in-group-housed-sows
#12
P H Hemsworth, R S Morrison, A J Tilbrook, K L Butler, M Rice, S J Moeller
Floor space is an important determinant of aggression and stress in group-housed sows, and the aim of the present experiment was to comprehensively examine the effects of floor space in the range of 1.45 to 2.90 m/sow from mixing until 27 d after insemination on aggression, stress, and reproduction of group-housed sows. A previous experiment on the effects of floor space indicated spatial variability across and along the research facility in both sow aggression and stress. To minimize this spatial variability within the research facility, similar-sized pens but with varying groups sizes (10-20) in 4 separate blocks of 3 contiguous pens within each of 9 time replicates (180 sows/replicate) were used to examine 6 space allowances (1...
November 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27898891/behavior-and-inflammation-of-the-rumen-and-cecum-in-holstein-bulls-fed-high-concentrate-diets-with-different-concentrate-presentation-forms-with-or-without-straw-supplementation
#13
M Devant, G B Penner, S Marti, B Quintana, F Fábregas, A Bach, A Arís
Twenty-four individually housed Holstein bulls (395 ± 7.3 kg BW and 252 ± 3.1 d age) were exposed to a 2 × 2 factorial design (meal vs. pellets; with vs. without straw) to evaluate the effect of concentrate form and provision of straw in finishing diets on behavior and expression of rumen and cecum epithelium genes related to inflammation and behavior. Concentrate and straw consumption were recorded monthly and behavior (self-grooming, social, oral nonnutritive, tongue rolling, eating, drinking, ruminating, and lying) was recorded every two weeks...
September 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27898878/effects-of-dietary-fiber-on-the-ideal-standardized-ileal-digestible-threonine-lysine-ratio-for-twenty-five-to-fifty-kilogram-growing-gilts
#14
J K Mathai, J K Htoo, J E Thomson, K J Touchette, H H Stein
Four experiments were conducted to determine effects of fiber on the ideal Thr:Lys ratio for 25- to 50-kg gilts. In Exp. 1, the objective was to determine the requirement for standardized ileal digestible Lys for gilts from 25 to 50 kg BW. Seventy gilts (24.54 ± 3.28 kg BW) were used in a growth assay with 2 pigs per pen, 5 diets, and 7 replicate pens per diet. The 5 diets were based on corn and soybean meal and contained between 0.80 and 1.32% SID Lys. Results indicated that 1.09% SID Lys was needed to optimize ADG and G:F...
October 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27898871/effect-of-disodium-calcium-malate-or-supplementation-on-growth-performance-carcass-quality-ruminal-fermentation-products-and-blood-metabolites-of-heifers
#15
C Carrasco, P Medel, A Fuentetaja, M J Ranilla, M D Carro
The aim of this study was to assess the effects of malate salts and culture on growth performance, carcass quality, ruminal fermentation products, and blood metabolites in heifers raised under southern Europe practical farm conditions. A total of 108 Charolaise cross heifers (214 ± 27.3 kg BW and 6.4 ± 1.1 mo of age) were housed in 18 pens of 6 animals each and used in a 114-d feedlot study. There was a totally randomized experimental design, and 6 pens were assigned to each of the following experimental diets: a control (no supplementation), the control plus 4 g of disodium/calcium malate mixture per kilogram of concentrate (2...
October 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27898861/interactions-between-levels-of-heat-treated-soybean-meal-and-prilled-fat-on-growth-rumen-fermentation-and-blood-metabolites-of-holstein-calves
#16
M Kazemi-Bonchenari, M Mirzaei, M Jahani-Moghadam, A Soltani, E Mahjoubi, R A Patton
This study evaluated the interaction of RUP and fat levels on growth, rumen fermentation, and blood metabolites of Holstein calves. Forty 3-d-old calves (20 females and 20 males) with a starting BW of 40.6 ± 2.8 kg were used in a completely randomized design with a 2 × 2 factorial arrangement of treatments. Within sex treatments were: (1) high RUP and low fat (HRUP-LF); (2) low RUP and high fat (LRUP-HF); (3) high RUP and low fat (HRUP-LF); and high RUP and high fat (HRUP-HF). Low-RUP starter contained 21...
October 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27898711/biochemical-characterization-of-glutamate-racemase-a-new-candidate-drug-target-against-burkholderia-cenocepacia-infections
#17
Aygun Israyilova, Silvia Buroni, Federico Forneris, Viola Camilla Scoffone, Namiq Q Shixaliyev, Giovanna Riccardi, Laurent Roberto Chiarelli
The greatest obstacle for the treatment of cystic fibrosis patients infected with the Burkholderia species is their intrinsic antibiotic resistance. For this reason, there is a need to develop new effective compounds. Glutamate racemase, an essential enzyme for the biosynthesis of the bacterial cell wall, is an excellent candidate target for the design of new antibacterial drugs. To this aim, we recombinantly produced and characterized glutamate racemase from Burkholderia cenocepacia J2315. From the screening of an in-house library of compounds, two Zn (II) and Mn (III) 1,3,5-triazapentadienate complexes were found to efficiently inhibit the glutamate racemase activity with IC50 values of 35...
2016: PloS One
https://www.readbyqxmd.com/read/27893448/in-field-evaluation-of-the-impact-of-ageing-and-fading-effects-on-annual-radon-concentration-measurements-for-two-different-techniques
#18
G Venoso, M Ampollini, S Antignani, C Carpentieri, F Bochicchio
Measurements covering a 1 year period are often used and required by legislation to assess the average radon concentration within a house or a workplace. This kind of long-term measurement-generally carried out with techniques based on nuclear track detectors-can be affected by a reduction in sensitivity due to ageing and fading of latent tracks during the exposure period, thus resulting in an underestimation of the actual average concentration. In order to evaluate in field conditions the ageing and fading effects on annual radon concentration measurements, two different studies in a large sample of rooms in dwellings (162) and in workplaces (432) were conducted using two different techniques (detector and track read-out system): (i) CR-39 plastics readout with a fully automated image analysis system, and (ii) LR 115 films with a spark-counter for track counting...
November 28, 2016: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/27891592/evaluation-of-a-cow-side-milk-progesterone-assay-and-assessment-of-the-positive-predictive-value-of-oestrus-diagnosis-by-dairy-farmers-in-new-south-wales
#19
L Ingenhoff, E Hall, J K House
OBJECTIVES: The three objectives of this study were to determine the positive predictive value (PPV) of oestrus diagnosis (heat detection accuracy) by dairy farmers, calculate the diagnostic sensitivity and specificity of the P4 Rapid milk progesterone assay for detecting a corpus luteum and evaluate the economics of using a cow-side milk progesterone assay designed to aid oestrus diagnosis. METHODS: Milk samples were collected from 752 cows diagnosed in oestrus by farm personnel on 14 dairy farms...
December 2016: Australian Veterinary Journal
https://www.readbyqxmd.com/read/27891506/synchronization-of-dairy-cows-does-not-limit-the-behavioral-response-to-treatment-in-mixed-treatment-experimental-designs
#20
Meagan T M King, Robin E Crossley, Trevor J DeVries
In many research studies, animals assigned to different treatments are housed adjacently or together in a group. One critique of these designs has been the potential role of behavioral facilitation and synchronization between animals on different treatments in mixed treatment groups (heterogeneous groups). To evaluate this, we compared the synchrony of feeding behavior between dairy cows housed in heterogeneous groups to cows exposed to the same treatment simultaneously (homogenous groups). Twenty-four cows were exposed to each of the two treatments over 21 days in a replicated cross-over design...
2016: Frontiers in Veterinary Science
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