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https://www.readbyqxmd.com/read/28637078/-update-cardiovascular-sleep-medicine
#1
Benedikt Linz, Michael Böhm, Dominik Linz
The prevalence of sleep-disordered breathing (SDB) is high in patients with cardiovascular diseases. Typical symptoms like daytime sleepiness can be absent and those patients may report unspecific, therapy-resistant symptoms related to their underlying disease. Particularly sleep-related symptoms like nocturia, nocturnal dyspnea and pectangina can be present. Based on the results of recently published studies, the treatment of central sleep apnea in patients with symptomatic, systolic heart failure by adaptive servo-ventilation is no longer recommended...
June 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28628341/observational-study-of-neural-respiratory-drive-during-sleep-at-high-altitude
#2
Joerg Steier, Nic Cade, Ben Walker, John Moxham, Caroline Jolley
Steier, Joerg, Nic Cade, Ben Walker, John Moxham, and Caroline Jolley. Observational study of neural respiratory drive during sleep at high altitude. High Alt Med Biol. 16:000-000, 2017. AIMS: Ventilation at altitude changes due to altered levels of pO2, pCO2 and the effect on blood pH. Nocturnal ventilation is particularly exposed to these changes. We hypothesized that an increasing neural respiratory drive (NRD) is associated with the severity of sleep-disordered breathing at altitude...
June 19, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28623043/nasal-airway-evaluation-in-obstructive-sleep-apnoea-patients-volumetric-tomography-and-endoscopic-findings
#3
M M Rodrigues, M F R Gabrielli, O A Garcia Junior, V A Pereira Filho, L A Passeri
Obstructive sleep apnoea (OSA) results from the recurrent collapse of the upper airway during sleep. Nasal abnormalities influence the stability of the pharynx. The aim of this study was to evaluate the volumetric and anatomical changes of the nasal cavity in patients with OSA. The Nasal Obstruction Symptom Evaluation (NOSE) scale was used to grade nasal obstruction. Sleep-related breathing disorders were evaluated by polysomnography. The nasal airway volume was obtained from computed tomography scans through volumetric reconstruction of the nasal airway...
June 13, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28619181/multifactorial-sleep-disturbance-in-parkinson-s-disease
#4
REVIEW
J Andrew Albers, Pratap Chand, A Michael Anch
Parkinson's disease (PD) is the second most common neurodegenerative disorder, ranking only behind Alzheimer's disease and affecting 2% of the population over the age of 65. Pathophysiologically, PD is characterized by selective degeneration of the dopaminergic neurons of the substantia nigra pars compacta (SNpc) and striatal dopamine depletion. Patients may also exhibit mild-to-severe degeneration of other central and peripheral nervous tissues. The most dramatic symptoms of the disease are profound dopamine-responsive motor disturbances, including bradykinesia, akinesia, rigidity, resting tremor, and postural instability...
July 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28619177/women-with-symptoms-of-sleep-disordered-breathing-are-less-likely-to-be-diagnosed-and-treated-for-sleep-apnea-than-men
#5
Eva Lindberg, Bryndis Benediktsdottir, Karl A Franklin, Mathias Holm, Ane Johannessen, Rain Jögi, Thorarinn Gislason, Francisco Gomez Real, Vivi Schlünssen, Christer Janson
BACKGROUND: Women are often underrepresented at sleep clinics evaluating sleep-disordered breathing (SDB). The aim of the present study was to analyze gender differences in sleep apnea diagnosis and treatment in men and women with similar symptoms of SDB. METHODS: Respiratory Health in Northern Europe (RHINE) provided information about snoring, excessive daytime sleepiness (EDS), BMI and somatic diseases at baseline (1999-2001) and follow-up (2010-2012) from 4962 men and 5892 women...
July 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28612268/discordant-sleep-parameters-among-actigraphy-polysomnography-and-perceived-sleep-in-patients-with-sleep-disordered-breathing-in-comparison-with-patients-with-chronic-insomnia-disorder
#6
Su Jung Choi, Miri Kang, Min Je Sung, Eun Yeon Joo
PURPOSE: Although the clinical usefulness of actigraphy (ACT) in chronic insomnia disorder (CID) is extensively investigated, the evaluation on the utility of ACT in sleep-disordered breathing (SDB) is limited and the report of comparison with perceived sleep by patients and polysomnography (PSG) is scarce. METHODS: Thirty-six patients with SDB and 30 with CID underwent PSG and ACT, and they reported perceived sleep time and latency simultaneously. Sleep parameters (total sleep time [TST], sleep onset latency [SOL], sleep efficiency, and wakefulness after sleep onset [WASO]) were compared...
June 14, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28608937/sleep-disturbance-and-sleep-disordered-breathing-in-hemodialysis-patients
#7
REVIEW
Ginger Chu, Peter Choi, Vanessa M McDonald
Sleep disturbance is one of the most common dialysis-related symptoms reported by hemodialysis patients. Poor sleep confers significant physical and psychological burden on patients with kidney disease and is associated with reduced quality of life and survival. More recent evidence also indicates that sleep-disordered breathing may be a risk factor for kidney injury.
June 13, 2017: Seminars in Dialysis
https://www.readbyqxmd.com/read/28587728/incidence-of-children-at-risk-for-obstructive-sleep-apnea-undergoing-common-day-surgery-procedures
#8
Emma M Holmes, Heena H K Singh, Valerie G Kirk, Mary Brindle, Jeremy Luntley, Bryce A Weber, Warren K Yunker
OBJECTIVE: The purpose of this study was to evaluate the prevalence of sleep-related breathing disorders (SRBD) in children undergoing elective day surgery procedures. METHODS: A validated Pediatric Sleep Questionnaire (PSQ) was distributed to the parents of children aged 2months to 18 years who met inclusion criteria and were undergoing urologic, otolaryngologic, and general surgical day surgery procedures a 3-month period of time. The prevalence of children at risk for pediatric SRBD was determined from PSQ results...
May 28, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28587727/-sleep-bruxism-in-children
#9
A Camoin, C Tardieu, I Blanchet, J-D Orthlieb
Bruxism is defined as repetitive activity of the masticatory muscles, characterized by clenching the teeth or teeth grinding and/or by tapping and swaying. This study investigated sleep bruxism. The etiology is multifactorial: mainly central (neuropathic disorder, anxiety) but also genetic and local (posture, mouth breathing). The diagnosis is based primarily on the anamnesis and examination of dental wear and progression over time (photos and dental castings). A diagnostic guide is proposed in this article...
June 3, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28577340/abnormal-growth-and-feeding-behavior-persist-after-removal-of-upper-airway-obstruction-in-juvenile-rats
#10
Mohammad H Assadi, Elena Shknevsky, Yael Segev, Ariel Tarasiuk
Pediatric obstructive sleep-disordered breathing is associated with growth retardation, but also with obesity that has a tendency to persist following treatment. We investigated the effect of upper airways obstruction (AO) and of obstruction removal (OR) in juvenile rats on gut-derived ghrelin and related hypothalamic factors, feeding, and growth hormone (GH) homeostasis. Here, we show that after seven weeks of AO, animals gained less weight compared to controls, despite an increase in food intake due to elevated ghrelin and hypothalamic feeding factors...
June 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28562535/the-structural-changes-of-upper-airway-and-newly-developed-sleep-breathing-disorders-after-surgical-treatment-in-class-iii-malocclusion-subjects
#11
Ui Lyong Lee, Hoon Oh, Sang Ki Min, Ji Ho Shin, Yong Seok Kang, Won Wook Lee, Young Eun Han, Young Jun Choi, Hyun Jik Kim
Bimaxillary surgery is the traditional treatment of choice for correcting class III malocclusion which is reported to cause an alteration of oropharyngeal structures and upper airway narrowing that might be a predisposing factor for obstructive sleep apnea (OSA). This study aimed to analyze sleep parameters in class III malocclusion subjects and ascertain the prevalence of snoring or OSA following bimaxillary surgery.A total of 22 patients with Le Fort I osteotomy and mandibular setback for class III malocclusion were prospectively enrolled...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28558865/early-onset-of-sleep-disordered-breathing-in-two-children-with-sepn1-related-myopathies
#12
Mathilde Viprey, Ha Trang, Michaël Pomedio, Katia Bessaci-Kabouya, Pascal Sabouraud, Fawzia Cheliout-Heraut, Pierre Mauran
Selenoprotein-related myopathy (SEPN1-RM) is a rare disease with a variable clinical presentation. The selenoproteinN1 gene (SEPN1) mutation causingthis congenital muscular dystrophy was identified in 2001. Sleep-disordered breathing (SDB) may occur in young patients with SEPN1-RM who are stillable to walk. We report the cases of two children with SEPN1-RM who presented with SDB at the ages of 7 and 12 years and for whom long-term nocturnalnoninvasive ventilation yielded significant improvement. Based on literature review and our current cases, it seems that there is no obvious relationshipbetween the time since SDB onset and outcome of pulmonary function tests or limb muscle weakness...
May 25, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28558398/-guidelines-in-practice-the-new-s3-guideline-sleeping-disorders-sleep-related-abnormal-breathing
#13
Martin Gerlach, Bernd Sanner
Sleep related breathing disorders include central sleep apnea (CSA), obstructive sleep apnea (OSA), sleep-related hypoventilation, and sleep-related hypoxia. These disorders are frequent and growing in clinical relevance. The related chapter of the S3 guideline "Non-restorative sleep/Sleep disorders", published by the German Sleep Society (DGSM), has recently been updated in November 2016. Epidemiology, diagnostics, therapeutic procedures, and classification of sleep related disorders have been revised. Concerning epidemiology, a considerably higher mortality rate among pregnant women with OSA has been emphasized...
May 30, 2017: Pneumologie
https://www.readbyqxmd.com/read/28553682/glycated-hemoglobin-and-sleep-apnea-syndrome-in-children-beyond-the-apnea-hypopnea-index
#14
J A Peña-Zarza, M De la Peña, A Yañez, J M Bauça, D Morell-Garcia, M Caimari, A Barceló, J Figuerola
PURPOSE: Snoring and obstructive sleep apnea syndrome (OSA) are frequent conditions in pediatrics. Glycated hemoglobin (HbA1C) is a useful homeostatic biomarker of glycemia and may reflect alterations deriving from sleep breathing disorders. The aim of this study was to relate the severity of OSA with blood HbA1C levels in children. METHODS: A descriptive observational study in snoring patients was performed. All patients underwent a sleep study and classified either as simple snorers (apnea-hypopnea index; AHI ≤ 1 episodies/h) or as OSA patients (AHI > 1 episodes/h)...
May 29, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28545360/melatonin-effects-in-rem-sleep-behavior-disorder-associated-with-obstructive-sleep-apnea-syndrome-a-case-series
#15
Carolin Schaefer, Dieter Kunz, Frederik Bes
OBJECTIVES: REM sleep behavior disorder (RBD), with its main clinical symptoms of nightmares with dream-enacting behavior, is considered as a possible precursor of neurodegenerative disease. Obstructive Sleep Apnea Syndrome (OSAS) is known to be capable of provoking RBD-like symptoms by apneic event related arousals. The two sleep related pathologies must coincide in a relevant number of individuals because of overlapping prevalence in similar age groups. Until now RBD symptoms coexisting with OSAS are rarely described in scientific literature and in fact considered as OSAS mimicking RBD...
May 22, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28534047/polysomnographic-heart-rate-variability-indices-and-atrial-ectopy-associated-with-incident-atrial-fibrillation-risk-in-older-community-dwelling-men
#16
Dileep Raman, Farhad Kaffashi, Li-Yung Lui, William H Sauer, Susan Redline, Peter Stone, Peggy M Cawthon, Katie L Stone, Kristine E Ensrud, Sonia Ancoli-Israel, Kenneth Loparo, Reena Mehra
BACKGROUND: Autonomic dysfunction contributes to atrial fibrillation (AF). OBJECTIVE: We hypothesized that polysomnogram (PSG)-based heart rate variability (HRV) autonomic function biomarkers are associated with incident AF and these associations are modified by measures of sleep disordered breathing (SDB). METHODS: 2350 participants of a multi-center prospective study (Outcomes of Sleep Disorders in Older Men Study) without baseline AF underwent sleep studies with incident adjudicated AF follow up (8...
May 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/28528846/the-multi-level-impact-of-chronic-intermittent-hypoxia-on-central-auditory-processing
#17
Eddie Wong, Bin Yang, Lida Du, Wai Hong Ho, Condon Lau, Ya Ke, Ying Shing Chan, Wing Ho Yung, Ed X Wu
During hypoxia, the tissues do not obtain adequate oxygen. Chronic hypoxia can lead to many health problems. A relatively common cause of chronic hypoxia is sleep apnea. Sleep apnea is a sleep breathing disorder that affects 3-7% of the population. During sleep, the patient's breathing starts and stops. This can lead to hypertension, attention deficits, and hearing disorders. In this study, we apply an established chronic intermittent hypoxemia (CIH) model of sleep apnea to study its impact on auditory processing...
May 19, 2017: NeuroImage
https://www.readbyqxmd.com/read/28522100/pulse-wave-amplitude-reduction-as-a-surrogate-for-cortical-arousal-during-sleep-hypopnea-in-children
#18
Alessandro Amaddeo, Noria Medjahdi, Marta Fernandez-Bolanos, Sonia Khirani, Guillaume Baffet, Brigitte Fauroux
OBJECTIVES: The accuracy of respiratory polygraphy (RP) is limited because of the absence of electroencephalography (EEG). Pulse wave amplitude (PWA) reduction has been shown to be a marker of autonomic activation during arousal, and may represent a substitute for obstructive respiratory-related cortical arousal (RRCA). This study tested the hypothesis that PWA could be a surrogate for RRCA in detecting obstructive hypopnea (OH) in a pediatric population. MATERIALS AND METHODS: Two experienced readers scored 30 consecutive polysomnographies (PSG) using standard scoring rules...
June 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28520763/genome-wide-gene-expression-array-identifies-novel-genes-related-to-disease-severity-and-excessive-daytime-sleepiness-in-patients-with-obstructive-sleep-apnea
#19
Yung-Che Chen, Kuang-Den Chen, Mao-Chang Su, Chien-Hung Chin, Chung-Jen Chen, Chia-Wei Liou, Ting-Wen Chen, Ya-Chun Chang, Kuo-Tung Huang, Chin-Chou Wang, Ting-Ya Wang, Jen-Chieh Chang, Yong-Yong Lin, Yi-Xin Zheng, Meng-Chih Lin, Chang-Chun Hsiao
We aimed to identify novel molecular associations between chronic intermittent hypoxia with re-oxygenation and adverse consequences in obstructive sleep apnea (OSA). We analyzed gene expression profiles of peripheral blood mononuclear cells from 48 patients with sleep-disordered breathing stratified into four groups: primary snoring (PS), moderate to severe OSA (MSO), very severe OSA (VSO), and very severe OSA patients on long-term continuous positive airway pressure treatment (VSOC). Comparisons of the microarray gene expression data identified eight genes up-regulated with OSA and down-regulated with CPAP treatment, and five genes down-regulated with OSA and up-regulated with CPAP treatment...
2017: PloS One
https://www.readbyqxmd.com/read/28511486/a-review-on-detection-and-treatment-methods-of-sleep-apnea
#20
REVIEW
Rajeswari Jayaraj, Jagannath Mohan, Adalarasu Kanagasabai
This paper presents a review on detection and treatment methods of sleep apnea. Sleep apnea is the most common type of breathing-related sleep disorder. It manifests in a variety of behaviours from teeth grinding to night terrors as involuntary night-time events. The most common sleep disorders are narcolepsy, hypersomnia, sleep talking, sleep walking, and bedwetting. Sleep apnea (somnipathy) is a serious sleep disorder that pauses breathing while sleeping. Breathing pauses occur 30 times or more during sleep and it lasts for few seconds to minutes, when normal breathing starts after this pause...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
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